E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.013 0.104 -9999.0 0.0 -0.348 11.0 11.0 KLHL20 -0.009 0.092 -9999.0 0.0 -0.247 17.0 17.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.01 0.081 0.276 3.0 -0.28 3.0 6.0 ENAH -0.014 0.105 -9999.0 0.0 -0.295 26.0 26.0 AP1M1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.047 -9999.0 0.0 -0.227 1.0 1.0 ABI1/Sra1/Nap1 -0.024 0.051 -9999.0 0.0 -0.167 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.07 -9999.0 0.0 -0.286 9.0 9.0 RAPGEF1 -0.007 0.098 0.274 3.0 -0.334 8.0 11.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.006 0.111 -9999.0 0.0 -0.292 32.0 32.0 CRK -0.006 0.094 -9999.0 0.0 -0.367 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.306 4.0 4.0 alphaE/beta7 Integrin 0.033 0.055 -9999.0 0.0 -0.353 5.0 5.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.029 -9999.0 0.0 -0.277 1.0 1.0 DLG1 -0.011 0.096 -9999.0 0.0 -0.293 23.0 23.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.491 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 -9999.0 0.0 -0.278 3.0 3.0 PI3K -0.001 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.052 -9999.0 0.0 -0.357 4.0 4.0 TIAM1 0.022 0.056 -9999.0 0.0 -0.491 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.048 -9999.0 0.0 -0.264 4.0 4.0 AKT1 0.004 0.04 0.161 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.065 -9999.0 0.0 -0.491 4.0 4.0 RhoA/GDP 0.013 0.082 0.276 3.0 -0.278 3.0 6.0 actin cytoskeleton organization -0.005 0.068 -9999.0 0.0 -0.181 16.0 16.0 CDC42/GDP 0.014 0.081 0.276 3.0 -0.278 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.013 0.035 -9999.0 0.0 -0.239 4.0 4.0 ITGB7 0.018 0.072 -9999.0 0.0 -0.491 5.0 5.0 RAC1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.051 -9999.0 0.0 -0.281 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.043 -9999.0 0.0 -0.261 4.0 4.0 mol:GDP -0.002 0.086 0.282 3.0 -0.317 3.0 6.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.023 0.085 0.297 2.0 -0.285 3.0 5.0 RAC1/GTP/IQGAP1 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.075 0.149 1.0 -0.208 27.0 28.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.098 -9999.0 0.0 -0.296 22.0 22.0 regulation of cell-cell adhesion 0.006 0.035 -9999.0 0.0 -0.197 2.0 2.0 WASF2 -0.001 0.036 -9999.0 0.0 -0.123 3.0 3.0 Rap1/GTP 0.02 0.058 0.272 2.0 -0.245 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.071 -9999.0 0.0 -0.272 9.0 9.0 CCND1 -0.016 0.092 0.17 1.0 -0.26 27.0 28.0 VAV2 -0.019 0.175 -9999.0 0.0 -0.637 13.0 13.0 RAP1/GDP 0.022 0.067 0.289 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.008 0.095 -9999.0 0.0 -0.288 22.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.064 -9999.0 0.0 -0.264 9.0 9.0 E-cadherin/beta catenin 0.006 0.038 -9999.0 0.0 -0.277 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.012 0.103 -9999.0 0.0 -0.349 11.0 11.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.046 0.13 -9999.0 0.0 -0.349 30.0 30.0 E-cadherin/beta catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.306 4.0 4.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.113 -9999.0 0.0 -0.298 32.0 32.0