Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.018 0.183 -9999.0 0.0 -0.671 18.0 18.0 IHH 0.023 0.058 -9999.0 0.0 -0.267 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.02 0.108 -9999.0 0.0 -0.304 30.0 30.0 LRPAP1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.107 0.303 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.018 0.102 -9999.0 0.0 -0.47 2.0 2.0 SMO -0.004 0.099 -9999.0 0.0 -0.431 4.0 4.0 AKT1 -0.001 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.057 -9999.0 0.0 -0.491 3.0 3.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.098 -9999.0 0.0 -0.425 4.0 4.0 STIL -0.022 0.113 -9999.0 0.0 -0.404 7.0 7.0 DHH N/PTCH2 0.014 0.097 -9999.0 0.0 -0.357 16.0 16.0 DHH N/PTCH1 0.011 0.106 -9999.0 0.0 -0.322 19.0 19.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.085 -9999.0 0.0 -0.491 7.0 7.0 PTHLH -0.023 0.19 -9999.0 0.0 -0.705 16.0 16.0 determination of left/right symmetry -0.004 0.098 -9999.0 0.0 -0.425 4.0 4.0 PIK3R1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.022 0.188 -9999.0 0.0 -0.697 16.0 16.0 IHH N/Hhip 0.001 0.12 -9999.0 0.0 -0.385 21.0 21.0 DHH N/Hhip -0.003 0.125 -9999.0 0.0 -0.369 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.098 -9999.0 0.0 -0.425 4.0 4.0 pancreas development -0.019 0.138 -9999.0 0.0 -0.49 20.0 20.0 HHAT 0.008 0.1 -9999.0 0.0 -0.491 10.0 10.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.003 0.109 -9999.0 0.0 -0.491 12.0 12.0 somite specification -0.004 0.098 -9999.0 0.0 -0.425 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.017 0.111 -9999.0 0.0 -0.373 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.018 0.098 -9999.0 0.0 -0.286 29.0 29.0 SHH Np/Cholesterol/Megalin -0.08 0.141 -9999.0 0.0 -0.289 77.0 77.0 SHH -0.031 0.102 -9999.0 0.0 -0.373 20.0 20.0 catabolic process 0.003 0.098 -9999.0 0.0 -0.345 18.0 18.0 SMO/Vitamin D3 -0.013 0.119 -9999.0 0.0 -0.44 7.0 7.0 SHH Np/Cholesterol/Hhip -0.032 0.119 -9999.0 0.0 -0.313 36.0 36.0 LRP2 -0.119 0.22 -9999.0 0.0 -0.491 66.0 66.0 receptor-mediated endocytosis -0.07 0.137 -9999.0 0.0 -0.464 9.0 9.0 SHH Np/Cholesterol/BOC -0.009 0.086 -9999.0 0.0 -0.284 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.093 -9999.0 0.0 -0.314 20.0 20.0 mesenchymal cell differentiation 0.032 0.118 0.311 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 -0.012 0.118 -9999.0 0.0 -0.402 8.0 8.0 IHH N/PTCH2 0.018 0.093 -9999.0 0.0 -0.393 11.0 11.0 CDON 0.023 0.046 -9999.0 0.0 -0.491 2.0 2.0 IHH N/PTCH1 0.012 0.101 -9999.0 0.0 -0.347 18.0 18.0 Megalin/LRPAP1 -0.062 0.173 -9999.0 0.0 -0.357 66.0 66.0 PTCH2 0.003 0.101 -9999.0 0.0 -0.491 10.0 10.0 SHH Np/Cholesterol -0.013 0.082 -9999.0 0.0 -0.287 20.0 20.0 PTCH1 0.003 0.098 -9999.0 0.0 -0.346 18.0 18.0 HHIP -0.019 0.138 -9999.0 0.0 -0.491 20.0 20.0