E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.048 0.103 -9999.0 0.0 -0.325 64.0 64.0 KLHL20 -0.059 0.078 0.476 1.0 -0.273 17.0 18.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.046 0.079 0.235 5.0 -0.252 20.0 25.0 ENAH -0.049 0.104 -9999.0 0.0 -0.323 66.0 66.0 AP1M1 0.026 0.009 -9999.0 0.0 0.0 66.0 66.0 RAP1B 0.028 0.006 -9999.0 0.0 0.0 22.0 22.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CTNNB1 0.028 0.007 -9999.0 0.0 -0.013 15.0 15.0 CDC42/GTP -0.059 0.05 0.116 22.0 -0.233 2.0 24.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.17 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.048 -9999.0 0.0 -0.142 9.0 9.0 RAPGEF1 -0.047 0.1 0.249 3.0 -0.308 56.0 59.0 CTNND1 0.029 0.004 -9999.0 0.0 -0.005 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.115 -9999.0 0.0 -0.324 68.0 68.0 CRK -0.047 0.103 -9999.0 0.0 -0.318 61.0 61.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.044 -9999.0 0.0 -0.156 20.0 20.0 alphaE/beta7 Integrin 0.04 0.014 -9999.0 0.0 -0.163 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.042 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.034 0.104 0.193 1.0 -0.325 54.0 55.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.044 0.042 -9999.0 0.0 -0.16 8.0 8.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.13 1.0 1.0 PI3K -0.054 0.054 -9999.0 0.0 -0.208 7.0 7.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.042 -9999.0 0.0 -0.176 19.0 19.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.051 0.043 -9999.0 0.0 -0.132 9.0 9.0 AKT1 -0.013 0.069 0.135 53.0 -9999.0 0.0 53.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.025 0.011 -9999.0 0.0 -0.003 79.0 79.0 RhoA/GDP -0.046 0.079 0.236 4.0 -0.252 19.0 23.0 actin cytoskeleton organization -0.044 0.058 0.412 1.0 -0.212 9.0 10.0 CDC42/GDP -0.045 0.08 0.236 5.0 -0.252 19.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.058 -9999.0 0.0 -0.188 36.0 36.0 ITGB7 0.029 0.003 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 28.0 28.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.046 -9999.0 0.0 -0.142 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.033 -9999.0 0.0 -0.121 9.0 9.0 mol:GDP -0.044 0.085 0.239 5.0 -0.277 21.0 26.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 41.0 41.0 p120 catenin/RhoA/GDP -0.048 0.082 0.241 4.0 -0.257 18.0 22.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 CTNNA1 0.029 0.005 -9999.0 0.0 -0.002 12.0 12.0 positive regulation of S phase of mitotic cell cycle -0.045 0.057 0.115 1.0 -0.131 141.0 142.0 NME1 0.027 0.008 -9999.0 0.0 0.0 42.0 42.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.05 0.106 -9999.0 0.0 -0.324 68.0 68.0 regulation of cell-cell adhesion -0.054 0.041 0.083 21.0 -0.207 2.0 23.0 WASF2 -0.031 0.035 0.09 4.0 -0.103 38.0 42.0 Rap1/GTP -0.055 0.058 0.251 2.0 -0.252 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.063 -9999.0 0.0 -0.151 20.0 20.0 CCND1 -0.055 0.069 0.131 1.0 -0.159 143.0 144.0 VAV2 -0.041 0.165 -9999.0 0.0 -0.653 24.0 24.0 RAP1/GDP -0.046 0.066 0.253 3.0 -0.254 3.0 6.0 adherens junction assembly -0.048 0.103 -9999.0 0.0 -0.315 68.0 68.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.171 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.022 0.046 -9999.0 0.0 -0.18 40.0 40.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.047 0.102 -9999.0 0.0 -0.327 62.0 62.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 170.0 170.0 Rac1/GTP -0.09 0.112 0.567 1.0 -0.386 37.0 38.0 E-cadherin/beta catenin/alpha catenin 0.048 0.032 -9999.0 0.0 -0.146 9.0 9.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.025 0.117 -9999.0 0.0 -0.33 68.0 68.0