Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.03 0.209 0.502 81.0 -0.452 15.0 96.0 IHH -0.005 0.078 0.159 91.0 -9999.0 0.0 91.0 SHH Np/Cholesterol/GAS1 -0.044 0.037 0.143 1.0 -0.131 76.0 77.0 LRPAP1 0.028 0.007 -9999.0 0.0 0.0 33.0 33.0 dorsoventral neural tube patterning 0.044 0.037 0.131 76.0 -0.142 1.0 77.0 SMO/beta Arrestin2 0.025 0.133 0.296 85.0 -0.388 9.0 94.0 SMO 0.028 0.134 0.307 84.0 -0.397 9.0 93.0 AKT1 -0.025 0.146 0.329 2.0 -0.449 18.0 20.0 ARRB2 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 BOC 0.025 0.01 -9999.0 0.0 0.0 80.0 80.0 ADRBK1 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 heart looping 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 STIL 0.001 0.065 0.273 20.0 -9999.0 0.0 20.0 DHH N/PTCH2 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.134 0.314 79.0 -0.293 8.0 87.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 170.0 170.0 DHH 0.029 0.002 -9999.0 0.0 0.0 4.0 4.0 PTHLH 0.032 0.193 0.495 71.0 -0.415 21.0 92.0 determination of left/right symmetry 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 skeletal system development 0.033 0.193 0.494 71.0 -0.412 21.0 92.0 IHH N/Hhip 0.048 0.042 0.181 3.0 -0.088 8.0 11.0 DHH N/Hhip 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 pancreas development 0.028 0.006 -9999.0 0.0 0.0 26.0 26.0 HHAT 0.028 0.005 -9999.0 0.0 0.0 19.0 19.0 PI3K -0.001 0.068 -9999.0 0.0 -0.163 77.0 77.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.011 -9999.0 0.0 0.0 95.0 95.0 somite specification 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 SHH Np/Cholesterol/PTCH1 -0.003 0.115 0.269 75.0 -0.268 8.0 83.0 SHH Np/Cholesterol/PTCH2 -0.032 0.016 0.143 1.0 -0.13 5.0 6.0 SHH Np/Cholesterol/Megalin -0.025 0.019 -9999.0 0.0 -0.13 4.0 4.0 SHH -0.03 0.014 0.194 1.0 -9999.0 0.0 1.0 catabolic process 0.023 0.159 0.379 84.0 -0.319 8.0 92.0 SMO/Vitamin D3 0.004 0.122 0.26 76.0 -0.363 9.0 85.0 SHH Np/Cholesterol/Hhip -0.031 0.017 0.143 1.0 -0.13 5.0 6.0 LRP2 0.022 0.013 -9999.0 0.0 0.0 140.0 140.0 receptor-mediated endocytosis 0.026 0.126 0.281 75.0 -0.403 8.0 83.0 SHH Np/Cholesterol/BOC -0.04 0.033 0.143 1.0 -0.13 55.0 56.0 SHH Np/Cholesterol/CDO -0.032 0.018 0.143 1.0 -0.13 7.0 8.0 mesenchymal cell differentiation 0.031 0.016 0.129 5.0 -0.142 1.0 6.0 mol:Vitamin D3 0.004 0.119 0.261 75.0 -0.268 8.0 83.0 IHH N/PTCH2 0.049 0.042 0.181 4.0 -0.088 7.0 11.0 CDON 0.028 0.007 -9999.0 0.0 0.0 32.0 32.0 IHH N/PTCH1 -0.034 0.054 -9999.0 0.0 -0.277 24.0 24.0 Megalin/LRPAP1 0.03 0.023 -9999.0 0.0 -0.163 2.0 2.0 PTCH2 0.028 0.005 -9999.0 0.0 0.0 20.0 20.0 SHH Np/Cholesterol -0.022 0.014 0.156 1.0 -0.119 5.0 6.0 PTCH1 0.023 0.159 0.38 84.0 -0.32 8.0 92.0 HHIP 0.028 0.006 -9999.0 0.0 0.0 26.0 26.0