rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 129925 2 2 2 0 0 0 1 0 1 0 0.885 0.0118 1.000 2 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(3), IL6(2), TGFB1(1), TGFB2(2) 724148 9 5 8 1 1 2 4 0 2 0 0.279 0.0174 1.000 3 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC2(1), CDC42(1), PAK1(2), PDGFRA(4), PIK3CA(1), PIK3R1(1), WASL(2) 1142933 12 6 11 2 2 2 2 3 3 0 0.398 0.0188 1.000 4 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), REN(4) 2187412 26 11 24 1 4 4 9 1 7 1 0.0299 0.0304 1.000 5 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPN1(1), CAPNS1(3), CDK5(1), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(1) 815671 14 7 12 1 3 4 1 0 6 0 0.102 0.0329 1.000 6 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TOB1(2) 915152 12 7 10 2 5 1 0 2 4 0 0.402 0.0401 1.000 7 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(1), LTB4R(3), P2RY1(2), P2RY2(1), P2RY6(1) 514396 9 5 8 1 4 1 2 0 2 0 0.186 0.0523 1.000 8 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IL12B(1) 256199 3 3 3 2 0 1 0 0 2 0 0.990 0.0758 1.000 9 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FSHB(1), FSHR(1), GNAS(6), XPO1(1) 837792 12 4 11 1 6 2 3 1 0 0 0.144 0.0787 1.000 10 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD4(2), CD58(2), IL6(2) 536223 8 3 8 1 1 0 2 3 2 0 0.367 0.0823 1.000 11 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(3), DPYS(4), GAD1(5), GAD2(4), HADHA(1), HIBCH(2), UPB1(2) 2328770 29 10 28 5 9 5 6 3 5 1 0.0733 0.106 1.000 12 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(2), CR2(4), FCGR2B(1), ICAM1(1), ITGB2(1), PTPRC(2) 1305486 12 6 12 1 2 3 1 3 3 0 0.103 0.113 1.000 13 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC3B(1), APOBEC3F(1), APOBEC4(2) 626256 6 4 5 1 2 2 0 0 2 0 0.460 0.120 1.000 14 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(6), CDC25A(2), CDC25C(2), MYT1(6), YWHAH(1) 1182342 17 7 15 3 2 3 2 3 7 0 0.395 0.139 1.000 15 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(2) 485087 8 3 7 2 3 2 1 0 2 0 0.400 0.141 1.000 16 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(5), CRY1(1), CSNK1E(1), PER1(2) 747048 10 4 9 0 2 0 0 3 5 0 0.0888 0.142 1.000 17 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), PC(2) 2251813 31 9 31 6 6 6 11 4 3 1 0.108 0.147 1.000 18 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(3), CASP1(2), CASP10(1), CASP8(2), PRF1(3) 1105130 14 6 13 4 2 3 0 2 7 0 0.691 0.154 1.000 19 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(1), FUT2(1) 620616 4 3 4 1 3 0 0 1 0 0 0.561 0.164 1.000 20 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CD4(2), IL1B(1), IL6(2) 394512 5 2 5 1 0 0 2 1 2 0 0.642 0.166 1.000 21 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 61729 3 1 3 1 2 0 0 0 1 0 0.718 0.172 1.000 22 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(2), CDC25C(2), CSK(1), SRC(1) 792964 6 5 4 1 1 1 0 0 4 0 0.686 0.174 1.000 23 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), SOS1(2) 1340175 11 5 11 1 3 3 1 2 2 0 0.147 0.181 1.000 24 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GLS(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), PPAT(2), QARS(1) 2860782 35 10 35 8 7 5 13 4 4 2 0.229 0.191 1.000 25 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(7), RANGAP1(2) 720855 10 3 10 2 1 2 2 2 2 1 0.530 0.209 1.000 26 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ARPC2(1), CDC42(1), WASF1(1), WASL(2) 694502 7 4 7 3 1 3 1 2 0 0 0.671 0.212 1.000 27 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), FARS2(2), GOT1(2) 706983 5 3 4 1 0 0 3 2 0 0 0.685 0.215 1.000 28 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(1), IL6(2), LPL(2) 455143 7 2 7 0 1 2 2 0 2 0 0.105 0.227 1.000 29 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(6), ATR(5), CDC25C(2), YWHAH(1) 1293581 14 6 13 5 1 2 4 2 5 0 0.895 0.228 1.000 30 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(6), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), DLAT(3), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), NARS2(1), PC(2), PDHA1(1) 3274451 42 12 41 9 8 8 13 4 8 1 0.141 0.228 1.000 31 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(6), CDC25A(2), CDC25C(2), CDK4(2), MYT1(6), RB1(1), YWHAH(1) 1439332 20 7 18 3 3 3 4 3 7 0 0.300 0.230 1.000 32 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(1), GOT1(2) 747034 5 3 4 1 1 0 3 1 0 0 0.649 0.238 1.000 33 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2) 642793 11 3 11 1 3 4 3 0 1 0 0.167 0.252 1.000 34 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 26 CCL3(1), CCR1(1), CCR4(2), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IL12B(1), IL4R(1), TGFB1(1), TGFB2(2) 1616086 16 5 15 4 4 3 2 4 3 0 0.364 0.265 1.000 35 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPOR(2), GRIN1(5), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1) 1104905 13 6 10 1 2 1 4 0 6 0 0.234 0.271 1.000 36 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), CHAT(3), GAD1(5), GAD2(4), SLC18A3(1), TPH1(2) 1267040 17 7 17 6 6 1 6 1 2 1 0.516 0.271 1.000 37 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SOD1(1) 1144953 12 4 12 3 3 2 1 2 4 0 0.468 0.272 1.000 38 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(1), IL6(2), IL7(1) 532430 6 2 6 1 0 1 2 2 1 0 0.508 0.274 1.000 39 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(2), SP1(1) 536378 3 3 3 0 0 0 1 0 2 0 0.841 0.275 1.000 40 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), FGA(3), FGB(4), FGG(1), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1) 1148137 15 4 14 3 2 4 5 2 2 0 0.330 0.277 1.000 41 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), RETN(2) 495952 7 3 6 1 1 0 2 1 3 0 0.530 0.279 1.000 42 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(5), GAD2(4) 499548 11 5 11 5 3 2 3 1 1 1 0.731 0.282 1.000 43 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1), MST1(4), MST1R(3) 565292 9 5 9 3 0 4 0 1 4 0 0.527 0.292 1.000 44 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 592478 9 5 9 2 1 2 3 2 1 0 0.415 0.294 1.000 45 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(4), MMP2(2), MMP9(2), RECK(3) 651583 12 4 11 4 5 1 2 0 4 0 0.571 0.297 1.000 46 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(2), KLRC1(1), KLRC2(2), PAK1(2), PIK3CA(1), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4) 1599610 19 6 18 3 5 2 3 4 4 1 0.168 0.305 1.000 47 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(4), GLS(1), GOT1(2) 670218 7 2 7 0 1 1 2 2 0 1 0.168 0.315 1.000 48 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(5), TPH1(2) 530093 7 3 7 3 1 0 2 1 2 1 0.768 0.316 1.000 49 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), LMNB1(1), LMNB2(1), PRF1(3) 1667335 19 7 18 3 4 5 2 1 7 0 0.252 0.322 1.000 50 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(1), CAMP(2), CREB1(1), SNX13(4), SRC(1), TERF2IP(1) 967945 13 4 13 2 2 1 2 4 4 0 0.350 0.325 1.000 51 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(8), ATM(6), BRCA1(3), MAPK8(1), MDM2(1), MRE11A(2), NFKBIA(2), RBBP8(2), RELA(1) 2494766 26 8 25 2 4 5 7 2 8 0 0.0648 0.338 1.000 52 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR2(1), NOS3(6), REN(4) 869950 13 6 11 2 3 0 5 0 5 0 0.462 0.344 1.000 53 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1) 520093 9 2 9 1 0 2 1 3 3 0 0.297 0.350 1.000 54 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(2), WASF1(1), WASF2(2), WASL(2) 1224212 17 5 17 3 6 5 2 3 1 0 0.163 0.352 1.000 55 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), KEAP1(1), MAFF(1), MAPK8(1), NFE2L2(1) 779413 5 3 5 1 1 0 0 2 2 0 0.548 0.358 1.000 56 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3) 277523 3 2 3 0 3 0 0 0 0 0 0.337 0.360 1.000 57 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), AKT1(2), BAD(1), BCL2L1(3), CSF2RB(1), IGF1R(4), KIT(3), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1) 1893862 26 6 24 4 7 5 3 4 7 0 0.0829 0.366 1.000 58 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADL(1), ACADSB(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(3), DPYS(4), GAD1(5), GAD2(4), HADHA(1), UPB1(2) 2500933 30 8 30 5 9 7 6 4 3 1 0.0383 0.367 1.000 59 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(2), CDC25C(2), CDK7(1), XPO1(1) 749706 6 4 4 1 1 0 0 0 5 0 0.737 0.371 1.000 60 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(2), ARFGAP3(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(3), GPLD1(2), KDELR2(1), KDELR3(1) 1390394 17 4 16 0 3 2 3 4 4 1 0.0104 0.377 1.000 61 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), BAD(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SOS1(2), YWHAH(1) 1411983 13 4 13 4 3 3 0 3 4 0 0.609 0.381 1.000 62 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(2) 331209 4 2 4 3 0 0 1 1 2 0 0.908 0.382 1.000 63 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(3) 171962 3 1 3 0 0 0 2 0 1 0 0.420 0.382 1.000 64 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDK7(1) 603514 3 3 2 1 0 0 0 0 3 0 0.899 0.385 1.000 65 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCNE1(1), CDK4(2), HRAS(1), NFKBIA(2), PAK1(2), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1) 1750102 14 6 13 6 2 2 4 2 4 0 0.919 0.388 1.000 66 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(1), RAB27A(1), RAB3A(1), RAB9A(2) 365555 7 2 7 1 3 3 0 1 0 0 0.188 0.392 1.000 67 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BCL2L1(3), BIRC2(1), CASP7(1), CASP8(2) 1172541 11 5 9 2 2 3 0 1 5 0 0.365 0.403 1.000 68 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 355588 1 1 1 0 0 0 0 0 1 0 0.830 0.405 1.000 69 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), GLS(1), OAT(2), PRODH(1) 488144 7 2 7 1 2 1 2 0 2 0 0.353 0.406 1.000 70 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(1), GLB1(1), HEXB(1), LCT(3), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1) 1361930 17 5 16 6 7 3 1 0 6 0 0.388 0.410 1.000 71 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(4), INPPL1(3), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1) 1696671 15 6 15 4 3 3 0 3 6 0 0.570 0.411 1.000 72 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(2) 4427332 51 12 50 8 14 10 9 9 9 0 0.0155 0.416 1.000 73 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(2) 4427332 51 12 50 8 14 10 9 9 9 0 0.0155 0.416 1.000 74 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA4(5), GABRA5(3), GABRA6(1), PRKCE(1), SOD1(1) 680877 11 2 11 1 3 3 1 1 2 1 0.0677 0.417 1.000 75 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), DHFR(1), FPGS(3), GCH1(1), GGH(1) 582636 16 4 15 3 6 5 0 1 4 0 0.0715 0.419 1.000 76 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ENPP3(2), FLAD1(3), RFK(1), TYR(2) 834072 9 4 7 1 2 3 1 0 3 0 0.300 0.423 1.000 77 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT2(1), CHST2(1), CHST4(1), CHST6(3), ST3GAL1(2) 1091684 10 4 10 0 3 1 3 1 2 0 0.0394 0.426 1.000 78 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 191010 2 1 2 1 0 0 0 1 1 0 0.765 0.434 1.000 79 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(8), MDM2(1), PIK3CA(1), PIK3R1(1), POLR1A(3), POLR1B(2), RB1(1) 1635759 17 4 16 3 3 3 5 1 5 0 0.259 0.437 1.000 80 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(3) 567857 4 2 4 0 2 0 0 0 2 0 0.356 0.437 1.000 81 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 821285 9 5 9 3 3 1 2 2 1 0 0.649 0.444 1.000 82 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 821285 9 5 9 3 3 1 2 2 1 0 0.649 0.444 1.000 83 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(1), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4) 1101673 10 3 10 1 2 3 0 2 2 1 0.152 0.447 1.000 84 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), JUND(1) 331008 2 2 2 0 0 0 0 1 1 0 0.809 0.448 1.000 85 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), BCL2L1(3), CASP8AP2(2) 959324 10 4 8 2 2 4 0 0 4 0 0.481 0.453 1.000 86 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(1), MTHFD2(1) 1094018 8 4 7 0 1 2 0 0 5 0 0.187 0.455 1.000 87 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2) 203972 2 1 2 1 0 0 0 1 1 0 0.905 0.458 1.000 88 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(1), MAPK7(4), MEF2A(1), MEF2D(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RPS6KA1(1) 1647659 16 5 16 2 3 5 2 1 5 0 0.155 0.459 1.000 89 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 140735 3 1 3 0 1 1 0 1 0 0 0.348 0.460 1.000 90 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(2), CHRNA1(3), FLT1(2), FLT4(8), KDR(1), NOS3(6), PDE2A(1), PDE3A(7), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(8), SLC7A1(1), TNNI1(1) 3545570 51 13 50 9 18 9 11 3 10 0 0.0141 0.483 1.000 91 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(1), MTHFD2(1) 1146428 8 4 7 1 1 2 0 0 5 0 0.429 0.485 1.000 92 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), EGFR(2), IGF1R(4), POLR2A(2), RB1(1), TEP1(7), TERF1(2), TERT(3), TNKS(3), XRCC5(2) 2367465 28 9 25 8 8 5 2 5 8 0 0.506 0.487 1.000 93 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(3) 550460 6 2 6 1 1 0 3 1 1 0 0.435 0.487 1.000 94 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), TOP2A(1), TOP2B(1) 794597 3 2 3 1 0 2 0 1 0 0 0.660 0.497 1.000 95 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), PC(2), PCK1(2), SDHA(3), SUCLA2(1), SUCLG1(1) 1772020 19 5 18 1 4 3 4 4 4 0 0.0411 0.502 1.000 96 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(5), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(2), PER2(3) 1483276 17 4 16 1 3 2 2 5 5 0 0.0416 0.503 1.000 97 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 159529 1 1 1 0 0 0 0 1 0 0 0.795 0.504 1.000 98 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(1), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4) 2206311 21 7 19 5 7 2 3 4 5 0 0.438 0.515 1.000 99 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR171(1), GPR18(1), GPR39(3), GPR75(1) 845494 7 3 7 3 1 1 0 3 2 0 0.781 0.519 1.000 100 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), LCT(3), PGM1(1), PYGM(2), TPI1(2) 1167521 10 3 10 9 1 2 2 1 4 0 0.948 0.531 1.000 101 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(1), PRF1(3), SET(1) 917489 6 4 5 2 0 1 1 1 3 0 0.838 0.534 1.000 102 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(2), CASP8(2), CRADD(2), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(4), RB1(1), SPTAN1(2), TNFRSF1A(2), TRADD(1), TRAF2(1) 3378256 34 11 32 5 10 1 9 4 10 0 0.135 0.534 1.000 103 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(3), CDC42(1), CHUK(1), HRAS(1), PIK3CA(1), PIK3R1(1), RALBP1(2), RALGDS(1), RELA(1) 1674590 15 6 13 5 2 4 1 2 6 0 0.771 0.547 1.000 104 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(3), ATM(6), BAD(1), BCL2L1(3), CASP7(1), PTK2(3), STAT1(1), TLN1(7) 2293876 27 6 25 4 6 8 3 3 7 0 0.0829 0.548 1.000 105 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD4(2) 275009 2 1 2 1 0 0 0 1 1 0 0.909 0.551 1.000 106 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(3), FGA(3), FGB(4), FGG(1), PROC(1), PROS1(1), SERPINC1(2), TFPI(2) 1405235 21 4 21 3 3 6 9 3 0 0 0.0979 0.555 1.000 107 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(1), ITGAM(1), ITGB2(1), SELP(3) 1377510 9 3 9 1 2 2 1 2 2 0 0.128 0.555 1.000 108 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(1) 748779 7 4 7 5 1 0 2 1 3 0 0.970 0.557 1.000 109 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(1) 289160 3 1 3 0 0 2 0 0 1 0 0.447 0.558 1.000 110 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(1) 1006344 7 3 7 0 2 1 2 0 2 0 0.148 0.569 1.000 111 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(1), GPI(1), HK1(2), PFKL(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2) 805357 12 2 12 4 2 5 1 2 2 0 0.317 0.572 1.000 112 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(3), CSF1(1), IL1B(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFSF8(3) 1171760 16 6 15 5 4 1 4 3 4 0 0.536 0.579 1.000 113 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), GAD1(5), GAD2(4), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1) 2223655 21 6 21 4 5 5 4 4 2 1 0.154 0.579 1.000 114 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(2), AKT1(2), ATM(6), CSNK1D(1), FHL2(1), HIC1(1), HIF1A(1), MAPK8(1), MDM2(1) 1737889 16 4 16 4 1 2 4 4 5 0 0.543 0.591 1.000 115 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(2), OGDHL(1), PC(2), PCK1(2), PCK2(3), SDHA(3), SUCLA2(1), SUCLG1(1) 2563823 27 6 26 4 9 3 4 4 6 1 0.0768 0.593 1.000 116 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(1), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1) 804074 11 4 11 2 2 2 1 3 3 0 0.344 0.595 1.000 117 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 HLA-A(2), ICAM1(1), ITGB2(1), PRF1(3) 751354 7 3 6 0 1 1 1 1 3 0 0.158 0.595 1.000 118 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNG(1), MUSK(3), PIK3CA(1), PIK3R1(1), PTK2(3), SRC(1), TERT(3), YWHAH(1) 1436502 17 5 17 3 3 4 0 4 6 0 0.186 0.596 1.000 119 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 760971 9 3 8 0 1 1 2 2 3 0 0.184 0.597 1.000 120 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(6), CCNE1(1), CDK4(2), MDM2(1), RB1(1) 1492424 14 3 14 3 3 3 4 2 2 0 0.427 0.599 1.000 121 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1) 800665 8 2 8 3 3 4 0 1 0 0 0.444 0.601 1.000 122 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(3), OGDH(2), SDHA(3), SUCLA2(1) 805527 10 2 10 1 3 1 2 2 2 0 0.170 0.602 1.000 123 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1) 884423 9 2 9 4 3 1 2 0 3 0 0.590 0.602 1.000 124 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(1), ITGAM(1), ITGB2(1) 903677 6 2 6 1 1 1 1 2 1 0 0.336 0.606 1.000 125 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(2), EPHA4(2), ITGA1(4), L1CAM(1), RAP1B(1), SELP(3) 1245848 13 4 13 2 4 3 1 2 3 0 0.141 0.607 1.000 126 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADHA(1), HSD17B4(2), NTAN1(2), SIRT1(1) 1020230 6 3 6 0 1 0 1 2 2 0 0.339 0.607 1.000 127 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(1), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(6), NCF2(1), PAK1(2), PDGFRA(4), PIK3CA(1), PIK3R1(1), RALBP1(2), TRIO(6), VAV1(4), WASF1(1) 3012660 35 6 34 9 9 6 6 6 6 2 0.305 0.609 1.000 128 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(1), GRM1(7), PLCB1(1), PPP1CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1382628 22 6 20 4 8 4 2 4 4 0 0.140 0.609 1.000 129 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA3(2), LPO(4), MPO(2), TPO(3) 726403 15 3 15 5 8 0 4 1 2 0 0.471 0.611 1.000 130 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(2), PIK3CA(1), PIK3R1(1), PLCB1(1), ROCK1(2) 2243034 17 6 16 3 2 3 3 3 6 0 0.331 0.614 1.000 131 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD86(1), IFNGR1(1), IL12B(1), IL2RA(1), IL4R(1) 1031467 5 2 5 0 1 1 0 2 1 0 0.206 0.617 1.000 132 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(1), PIK3R1(1), RELA(1), YWHAH(1) 1223327 11 4 11 3 0 3 3 1 4 0 0.585 0.621 1.000 133 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA4(5), GABRA5(3), GABRA6(1), SRC(1), UBQLN1(3) 1038405 15 2 15 1 4 3 4 2 1 1 0.0350 0.623 1.000 134 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(3), BMPR2(1) 537379 9 3 9 2 2 3 1 1 2 0 0.451 0.624 1.000 135 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(3), NFKBIA(2), RELA(1) 788619 7 3 7 3 0 1 2 2 2 0 0.803 0.624 1.000 136 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR6(1), NFS1(1), PHPT1(1), TPK1(1) 550789 4 2 4 2 0 2 1 0 1 0 0.902 0.632 1.000 137 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1) 340531 3 1 3 1 0 0 1 1 1 0 0.845 0.633 1.000 138 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K6(3), MAP3K1(3), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1), SP1(1) 1680605 14 5 13 5 1 1 6 2 4 0 0.858 0.647 1.000 139 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(2), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1136616 14 5 13 2 5 1 2 2 4 0 0.265 0.649 1.000 140 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), DPYD(3), DPYS(4), ENPP3(2), PANK4(1), UPB1(2) 1213960 14 5 14 3 3 5 2 2 2 0 0.223 0.651 1.000 141 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHSY1(1), DSE(2), XYLT1(2), XYLT2(4) 1292106 16 8 14 9 7 2 2 1 4 0 0.809 0.655 1.000 142 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(4), AXIN1(3), CD14(2), CTNNB1(6), DVL1(4), FZD1(4), GNAI1(1), GSK3B(1), LEF1(2), LY96(1), PIK3CA(1), PIK3R1(1), RELA(1), WNT1(1) 2679433 34 8 34 5 11 7 5 7 4 0 0.0420 0.661 1.000 143 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(1), ITGB2(1) 1041413 5 2 5 1 1 0 1 2 1 0 0.473 0.661 1.000 144 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(2), LPO(4), MPO(2), PRDX1(1), TPO(3), TYR(2) 836919 18 3 18 6 9 0 6 1 2 0 0.443 0.665 1.000 145 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B5(1), ELAVL1(1), FLT1(2), FLT4(8), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3) 2945460 27 7 27 4 7 5 8 1 6 0 0.0590 0.670 1.000 146 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(1), IL12B(1), IL6(2), IL7(1), TGFB1(1), TGFB2(2) 1160604 10 4 9 2 1 2 2 2 3 0 0.462 0.673 1.000 147 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(2), ABCB11(2), ABCB4(5), ABCC3(2), GSTP1(1) 1231186 12 5 10 3 0 3 1 3 5 0 0.634 0.684 1.000 148 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(2), HK2(2), HK3(2), ISYNA1(1), PGM1(1), PGM3(1) 1016390 10 2 10 5 4 1 2 0 3 0 0.613 0.686 1.000 149 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(1), PLCG1(1) 1189126 6 2 6 2 0 2 1 1 2 0 0.516 0.690 1.000 150 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ENPP3(2), FLAD1(3), MTMR6(1), PHPT1(1), RFK(1), TYR(2) 1294241 11 4 9 3 2 4 2 0 3 0 0.611 0.691 1.000 151 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), SHMT1(1), SHMT2(3) 367490 6 1 6 3 2 1 2 0 1 0 0.735 0.694 1.000 152 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), CREB1(1), EDN1(1), EP300(4), HIF1A(1), NOS3(6) 1470519 15 3 15 2 3 2 4 2 4 0 0.211 0.698 1.000 153 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD80(1), CD86(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1) 1093621 6 2 6 3 1 1 1 1 2 0 0.851 0.699 1.000 154 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(1), HRAS(1), IGF1R(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SOS1(2) 1928801 12 3 12 6 3 2 0 3 4 0 0.885 0.701 1.000 155 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(2), ERBB3(3), NRG1(3), UBE2D1(1) 882106 11 3 11 1 1 2 3 2 3 0 0.222 0.702 1.000 156 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), PRF1(3), SCAP(1), SREBF2(4) 1616744 16 6 14 3 3 5 0 1 7 0 0.227 0.705 1.000 157 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(1), EP300(4), NCOA3(3), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1782717 16 3 16 5 5 2 4 2 2 1 0.474 0.710 1.000 158 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(4), AXIN1(3), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMPR1A(3), BMPR2(1), CHRD(2), CTNNB1(6), DVL1(4), FZD1(4), GATA4(1), GSK3B(1), MAP3K7(2), RFC1(3), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), WNT1(1) 3173810 50 10 48 6 19 10 5 11 5 0 0.00384 0.711 1.000 159 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), GOT1(2), LDHB(1), SULT1B1(2), SULT1C4(1), SULT4A1(1) 1085208 9 3 8 1 1 1 2 2 3 0 0.384 0.715 1.000 160 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 533277 9 2 9 1 3 0 1 2 3 0 0.215 0.718 1.000 161 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(2), EGFR(2), HRAS(1), PTPRB(8), RASA1(1), SOS1(2), SPRY4(2), SRC(1) 2146213 21 6 20 2 1 7 2 5 5 1 0.0824 0.718 1.000 162 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(1), DAXX(2), HRAS(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAP3K9(2), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), RPS6KA5(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1) 3194471 31 12 28 9 7 2 8 4 10 0 0.633 0.719 1.000 163 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1B(1), PRMT3(1), PRMT6(1), PRMT8(1) 1219211 10 3 10 3 0 3 5 0 2 0 0.662 0.725 1.000 164 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), B4GALT5(2), ST3GAL1(2) 689852 5 2 5 1 1 0 2 1 1 0 0.665 0.727 1.000 165 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), PAPSS1(2), PAPSS2(3), SCLY(2) 1070799 9 2 9 7 2 2 2 1 2 0 0.930 0.727 1.000 166 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F12(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), LPA(3), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(4) 3030724 33 7 32 5 9 8 11 2 3 0 0.0420 0.727 1.000 167 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), MUT(2) 426371 3 1 3 2 0 0 0 1 2 0 0.905 0.735 1.000 168 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(3), EGF(2), EGFR(2), MET(4), PDGFRA(4), SH3GLB1(1), SRC(1) 1666327 19 4 18 2 4 4 3 3 5 0 0.0932 0.736 1.000 169 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C6(3), C7(3), C8A(3), C9(1) 1075527 15 4 15 5 2 5 4 3 1 0 0.618 0.736 1.000 170 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 742852 7 3 7 4 3 0 2 0 2 0 0.793 0.737 1.000 171 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HBXIP(1), HRAS(1), SOS1(2), SRC(1) 760205 6 2 6 1 1 2 1 1 1 0 0.445 0.740 1.000 172 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK2(2), PTPRU(6), STAT1(1) 982768 10 3 10 4 4 1 3 1 1 0 0.660 0.743 1.000 173 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(1), ACAT1(2), HADHA(1) 466393 5 1 5 0 0 3 1 0 1 0 0.238 0.746 1.000 174 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(3), TPO(3) 1001311 20 3 20 6 8 3 4 2 3 0 0.302 0.749 1.000 175 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(1), B4GALT5(2), DDOST(1), DPAGT1(2), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), ST6GAL1(1) 1741660 13 6 12 4 4 1 1 2 5 0 0.742 0.749 1.000 176 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), GLB1(1), HEXB(1), LCT(3), MANBA(2), NEU4(1) 1452219 11 4 11 4 4 1 2 0 4 0 0.563 0.753 1.000 177 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), GNAS(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1) 1149627 18 4 17 4 8 6 3 1 0 0 0.162 0.760 1.000 178 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), SHMT1(1), SHMT2(3), TPO(3) 1023769 20 3 20 5 8 3 5 1 3 0 0.193 0.760 1.000 179 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPNS1(3), EP300(4), MEF2D(1), NFATC1(4), NFATC2(4), PPP3CA(1), PPP3CC(1) 2097941 20 7 20 7 5 6 0 2 7 0 0.450 0.761 1.000 180 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX3(1), PLA2G3(2), PLA2G6(3) 805917 6 2 6 4 0 2 2 1 1 0 0.932 0.764 1.000 181 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), CPOX(1), PPOX(2) 661850 5 4 5 2 1 2 1 0 1 0 0.779 0.769 1.000 182 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), DPYD(3), DPYS(4), ENPP3(2), ILVBL(2), PANK4(1), UPB1(2), VNN1(1) 1506150 18 5 18 3 5 6 3 2 2 0 0.0882 0.769 1.000 183 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(2), EIF4A2(1), EIF4G1(6), EIF4G3(5), GHR(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1) 2092030 19 5 19 4 4 6 3 3 3 0 0.257 0.772 1.000 184 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GNRHR(1), GPR77(1), GRPR(1), MC2R(2), MC3R(2), MC5R(1), NPY1R(1), NPY2R(3), NPY5R(1), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), SSTR1(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3) 4466353 62 15 62 16 20 8 17 10 6 1 0.0220 0.774 1.000 185 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(1), SCAP(1), SREBF2(4) 1074016 6 4 5 6 1 1 0 1 3 0 0.988 0.775 1.000 186 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(1), PIK3CD(1), SOS1(2) 1427480 10 4 10 6 5 1 0 2 2 0 0.883 0.775 1.000 187 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), CYP3A7(3), DHRS1(1), DHRS3(2), PON1(1), PON2(1) 1562047 19 5 18 5 7 3 1 4 4 0 0.312 0.778 1.000 188 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(2), NR1H4(2) 465961 4 1 4 1 0 2 1 0 1 0 0.452 0.779 1.000 189 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1) 1294451 11 3 11 4 0 3 5 1 2 0 0.731 0.782 1.000 190 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 145540 1 1 1 1 0 0 1 0 0 0 0.968 0.783 1.000 191 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(2), SHMT1(1), SHMT2(3) 485875 6 1 6 3 2 1 2 0 1 0 0.763 0.785 1.000 192 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(1), EP300(4), ESR1(1), SRC(1) 1293597 7 2 7 1 1 2 2 1 1 0 0.274 0.785 1.000 193 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(1), CDK5R1(1), HRAS(1), KLK2(1), NGFR(1) 627865 5 3 5 3 3 0 1 0 1 0 0.897 0.786 1.000 194 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), UBE3A(3) 1109524 9 4 9 4 3 0 2 1 3 0 0.849 0.788 1.000 195 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(1), GNAS(6), GNB1(1), NOS3(6), NR3C1(2), PIK3CA(1), PIK3R1(1), RELA(1) 1574187 21 5 20 5 5 3 8 2 3 0 0.515 0.789 1.000 196 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), PRKACG(2), PRKAR2B(1) 869441 6 2 6 0 1 2 1 1 1 0 0.185 0.796 1.000 197 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), PTPRU(6), STAT1(1), STAT2(1), TYK2(1) 1078205 11 3 11 4 6 1 3 1 0 0 0.545 0.796 1.000 198 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(1), ENPEP(3), LNPEP(2), MME(2), REN(4), THOP1(1) 1824729 20 7 18 4 3 5 4 4 4 0 0.247 0.798 1.000 199 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(2), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), SOS1(2) 1676503 13 4 13 3 3 5 0 2 3 0 0.278 0.799 1.000 200 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(3), DDX20(1), E2F4(3), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(3) 2295405 23 5 22 8 4 6 5 3 5 0 0.572 0.800 1.000 201 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(1) 779972 9 2 9 3 2 1 4 1 1 0 0.667 0.803 1.000 202 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(6), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1) 1457169 23 7 23 7 9 5 7 1 1 0 0.264 0.804 1.000 203 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(2), HSD3B7(2), PON1(1), PON2(1), RDH11(2) 774976 9 2 9 2 2 1 2 3 1 0 0.450 0.809 1.000 204 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), FURIN(2), NOTCH1(5), PSEN1(1) 848285 11 2 11 4 5 5 1 0 0 0 0.243 0.813 1.000 205 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(1), SOS1(2), STAT5A(1) 2639601 19 5 19 4 6 3 4 3 3 0 0.251 0.817 1.000 206 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), F10(4), F12(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1) 3841222 43 9 43 4 6 10 18 3 5 1 0.0141 0.818 1.000 207 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), ATIC(1), DHFR(1), FTCD(2), MTFMT(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(3), TYMS(1) 1631687 19 5 18 7 3 3 4 3 6 0 0.659 0.822 1.000 208 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), PGM3(1), RENBP(1) 1467187 17 4 17 6 6 3 4 1 3 0 0.422 0.824 1.000 209 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), SLC2A1(2) 2184023 21 6 21 5 3 5 7 1 4 1 0.517 0.827 1.000 210 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ2(2) 1916732 15 5 15 5 2 4 2 2 5 0 0.603 0.830 1.000 211 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C6(3), C7(3), ICAM1(1), IL6(2), ITGB2(1), SELP(3) 2122250 18 5 18 7 3 6 5 1 3 0 0.587 0.831 1.000 212 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1) 1420605 9 4 9 5 1 2 0 3 3 0 0.901 0.833 1.000 213 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(5), GPRC5A(2), GPRC5B(4), GPRC5C(5), GRM1(7), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM7(4), GRM8(2) 1801986 41 10 35 10 6 12 5 4 14 0 0.241 0.833 1.000 214 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CCND2(1), CCND3(1), CCNE1(1), CDC25A(2), CDK4(2), CDK7(1), RB1(1), RBL1(1) 1344187 12 3 11 4 1 2 3 3 3 0 0.698 0.834 1.000 215 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), BPNT1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PTEN(1), RBL2(2), SOS1(2) 1759494 12 4 12 5 2 3 1 4 2 0 0.733 0.840 1.000 216 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1) 601181 7 2 7 2 2 2 0 2 1 0 0.555 0.841 1.000 217 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1) 623763 5 1 5 1 0 3 0 0 2 0 0.420 0.842 1.000 218 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 6 CDK5(1), CDK5R1(1), RELN(6) 1096439 8 3 8 6 3 1 1 1 2 0 0.951 0.844 1.000 219 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(1), PLCB1(1), TUB(1) 613657 4 1 4 1 0 1 0 2 1 0 0.577 0.849 1.000 220 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GFPT2(1), GLS(1), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), NAGK(1), PPAT(2), QARS(1) 3408057 38 10 38 10 7 6 14 5 4 2 0.305 0.850 1.000 221 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(1), EIF4B(2), EIF4G1(6), EIF4G3(5), FKBP1A(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), TSC1(1), TSC2(4) 2383621 26 5 26 8 7 8 5 3 3 0 0.453 0.852 1.000 222 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 183461 3 1 3 0 0 1 2 0 0 0 0.409 0.856 1.000 223 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2) 2578259 24 8 21 6 3 2 7 4 8 0 0.488 0.862 1.000 224 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1) 1509534 20 5 20 6 2 5 5 5 3 0 0.525 0.867 1.000 225 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(3), FH(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(2), PC(2), PDHA1(1), PDK1(1), PDK2(1), SDHA(3), SUCLA2(1), SUCLG1(1) 2452323 22 3 22 4 8 3 3 4 4 0 0.129 0.867 1.000 226 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(1), EP300(4), IKBKB(2), IL1B(1), MAP2K6(3), MAP3K7(2), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(4), TLR2(1) 2574604 27 6 25 5 5 5 7 4 6 0 0.140 0.868 1.000 227 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(3), PRL(1), TRH(2) 969078 10 3 10 4 4 1 2 1 2 0 0.637 0.869 1.000 228 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(2), AKT1(2), CDC42(1), FLNA(5), FLNC(7), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(2), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2) 4174931 46 12 45 14 8 8 13 10 7 0 0.403 0.870 1.000 229 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2S(1), UBE3A(3) 909483 10 2 10 0 5 2 2 0 1 0 0.0329 0.873 1.000 230 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PAPSS1(2), PAPSS2(3), PRMT3(1), PRMT6(1), PRMT8(1), SCLY(2) 2156223 17 3 17 9 2 4 7 1 3 0 0.866 0.874 1.000 231 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCG2(1), BCHE(4), UGT1A1(2) 1674633 7 4 7 4 0 2 0 2 3 0 0.885 0.875 1.000 232 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(3), DAXX(2), FAS(1), FASLG(1), MAPKAPK3(1) 978899 10 3 10 3 2 4 1 2 1 0 0.429 0.880 1.000 233 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1116229 9 3 9 2 4 2 2 0 1 0 0.365 0.882 1.000 234 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(1), G6PC2(1), GAA(1), GANC(1), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), HSD3B7(2), LCT(3), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH11(2), UGP2(2) 3360220 27 8 27 9 9 5 5 2 6 0 0.320 0.882 1.000 235 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(1), CREBBP(1), EP300(4), ERCC3(4), ESR1(1), GRIP1(1), GTF2F1(2), HDAC4(2), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(1) 4074998 30 9 28 9 7 8 4 3 8 0 0.427 0.883 1.000 236 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), BDH1(1), DDHD1(2), GAD1(5), GAD2(4), HADHA(1), HMGCS2(1), HSD17B4(2), HSD3B7(2), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2) 3511983 34 8 34 7 8 8 7 7 3 1 0.0822 0.883 1.000 237 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(1), PLCG1(1), SOS1(2) 1656727 10 3 10 4 2 3 1 1 3 0 0.747 0.887 1.000 238 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(1), HEXB(1), LCT(3), NAGLU(2) 1269885 10 4 10 5 2 3 1 0 4 0 0.658 0.890 1.000 239 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), GREB1(3), MTA1(1), PDZK1(2), TUBA8(2) 965242 10 3 10 2 0 5 1 2 2 0 0.198 0.890 1.000 240 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), PFKFB1(2), PFKFB4(2), PFKM(1), PFKP(1), PMM2(1), TPI1(2) 2079132 23 6 23 6 9 4 6 1 3 0 0.165 0.893 1.000 241 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2) 224768 2 1 2 0 0 0 1 1 0 0 0.652 0.893 1.000 242 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(4), AXIN1(3), BTRC(1), CREBBP(1), CSNK1D(1), CSNK2A1(1), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(2), WIF1(1), WNT1(1) 2578684 34 7 33 7 10 7 6 6 5 0 0.146 0.895 1.000 243 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(1), FBP2(1), GAA(1), GANAB(2), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), LCT(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 2828284 21 7 21 9 7 2 5 1 6 0 0.637 0.897 1.000 244 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(3), CDC25C(2), GNAI1(1), GNAS(6), GNB1(1), HRAS(1), MYT1(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), SRC(1) 1801182 30 8 28 6 11 8 4 4 3 0 0.0812 0.899 1.000 245 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(2), MAP3K1(3), NCOR2(4) 1514202 11 3 11 7 1 3 2 2 3 0 0.938 0.899 1.000 246 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PAK1(2), PLCG1(1), SOS1(2), SRC(1) 2474345 16 3 15 7 2 4 3 3 4 0 0.813 0.901 1.000 247 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), AKT1(2), CAMK2D(1), CREB1(1), GNAS(6), HRAS(1), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(2) 2535181 26 6 25 4 9 5 4 3 5 0 0.102 0.901 1.000 248 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(3), GNAQ(1), GNB1(1), MYLK(6), PLCB1(1), ROCK1(2) 1779621 17 3 17 7 2 3 4 4 4 0 0.772 0.903 1.000 249 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT12(1) 1858251 17 3 16 4 6 3 2 2 4 0 0.287 0.908 1.000 250 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 1765782 20 4 20 5 5 4 7 2 2 0 0.181 0.910 1.000 251 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1), MASP1(1) 1790185 21 5 21 6 2 5 5 6 3 0 0.482 0.913 1.000 252 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E2(1), GTF2F1(2), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6L(2) 3099549 22 7 22 8 7 2 5 4 4 0 0.763 0.913 1.000 253 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), RPE(2), UGDH(1), UGT1A1(2), UGT2B15(1), UGT2B4(1) 1500472 8 2 8 2 1 2 2 1 2 0 0.518 0.915 1.000 254 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), AXIN1(3), CREBBP(1), CTNNB1(6), DVL1(4), EP300(4), FZD1(4), GSK3B(1), LDB1(1), LEF1(2), TRRAP(7), WNT1(1) 2871748 38 6 38 7 13 8 6 9 2 0 0.0326 0.916 1.000 255 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SNAP23(1), SNAP29(3), STX3(1), STX4(2), TSNARE1(1), VTI1A(1) 1456376 10 3 10 7 5 0 0 2 3 0 0.925 0.916 1.000 256 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1), MASP1(1) 1837827 21 5 21 7 2 5 5 6 3 0 0.594 0.920 1.000 257 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMD1(2), PSMD11(1), PSMD12(1) 1369197 10 3 10 7 1 1 3 3 2 0 0.963 0.920 1.000 258 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), MAF(3), NFATC1(4), NFATC2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1072401 18 3 18 4 9 5 1 0 3 0 0.0600 0.921 1.000 259 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), ASAH1(1), CAMP(2), CERK(1), CREB1(1), DAG1(2), EPHB2(1), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1) 2506213 28 5 28 5 9 3 4 6 6 0 0.0938 0.921 1.000 260 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(3), AGPAT4(3), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH2(2), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2) 2008347 22 4 22 8 6 4 4 4 4 0 0.611 0.922 1.000 261 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA2(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRB(2), HSD11B1(1), PRL(1), PTGDR(2), PTGDS(2), PTGFR(1), PTGIS(2), TBXAS1(1) 1799327 19 5 19 7 8 2 4 3 2 0 0.488 0.922 1.000 262 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(2), IL4R(1), JAK3(3), STAT6(1) 1076349 7 2 7 7 2 1 1 2 1 0 0.986 0.923 1.000 263 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(5), CPOX(1), PPOX(2), UGT1A1(2), UGT2B15(1), UGT2B4(1) 2339583 14 5 14 2 1 4 1 2 6 0 0.273 0.928 1.000 264 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), PPARA(1), RELA(1), TLR2(1), TLR3(2), TLR6(2), TLR9(6) 3167310 32 7 30 8 7 4 8 5 8 0 0.359 0.928 1.000 265 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(6), CCND2(1), CDK4(2), ESR2(1), FSHR(1), GJA4(1), MLH1(1), NCOR1(6), NRIP1(1), PGR(3), PRLR(2) 2933154 25 5 25 9 6 4 6 5 4 0 0.589 0.928 1.000 266 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), AKT1(2), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(2), ITGB3(1), PDGFRA(4), PIK3CA(1), PIK3R1(1), PLCB1(1), PTK2(3), SPHK1(1), SRC(1) 2358428 23 3 23 1 5 7 2 5 4 0 0.00336 0.929 1.000 267 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 265293 5 1 5 1 0 1 1 3 0 0 0.595 0.930 1.000 268 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 IL12B(1), JAK2(2), MAP2K6(3), MAPK8(1), TYK2(1) 1617609 8 2 7 1 2 1 2 0 3 0 0.198 0.930 1.000 269 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), MAP3K7(2), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 2389802 21 6 20 8 4 2 6 4 5 0 0.752 0.931 1.000 270 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 11 ACAA1(1), ACOX3(1), FADS1(1), FASN(9), HADHA(1) 1145968 13 3 13 3 4 4 3 0 1 1 0.136 0.931 1.000 271 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(1), HRAS(1), INSR(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SOS1(2) 1994744 12 3 12 5 4 2 0 3 3 0 0.747 0.935 1.000 272 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(1), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), SOS1(2), STAT1(1), STAT5A(1) 2421536 18 4 18 5 3 2 5 4 4 0 0.525 0.936 1.000 273 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), MEF2A(1), MEF2D(1), PAK1(2), PTK2(3), SOS1(2), SRC(1) 2905959 20 3 19 6 2 4 3 4 7 0 0.552 0.940 1.000 274 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), ST8SIA1(2) 1418020 11 2 11 1 6 2 2 0 1 0 0.0875 0.941 1.000 275 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), MAP3K1(3), MAP3K7(2), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 2132857 16 5 15 9 2 2 7 2 3 0 0.964 0.945 1.000 276 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), CAPN1(1), CAPNS1(3), ITGA1(4), ITGB3(1), PTK2(3), SPTAN1(2), SRC(1), TLN1(7) 2478188 30 4 30 7 10 9 3 2 6 0 0.0783 0.946 1.000 277 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), TPO(3) 1903218 28 3 28 7 14 3 6 3 2 0 0.110 0.946 1.000 278 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), SOS1(2), SYK(2), VAV1(4), VAV3(1) 2798487 21 4 21 4 6 3 3 4 4 1 0.144 0.947 1.000 279 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PDHA1(1), PKLR(1) 3182862 28 3 28 7 5 12 2 3 6 0 0.204 0.947 1.000 280 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), TRAF2(1), TRAF5(1) 2986646 23 5 23 6 5 7 4 3 4 0 0.189 0.947 1.000 281 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(2), LUM(1) 311184 3 1 3 1 0 1 0 2 0 0 0.631 0.947 1.000 282 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(1), CDC42(1), CREB1(1), DUSP10(1), MAP2K4(2), MAP2K6(3), MAP3K10(3), MAP3K4(2), MAP3K7(2), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1) 2938039 23 8 21 8 5 3 5 3 7 0 0.672 0.948 1.000 283 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 2104472 21 4 21 4 5 5 7 2 2 0 0.0814 0.949 1.000 284 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(1), AKT1(2), BAD(1), BTK(1), DAPP1(1), GSK3A(1), GSK3B(1), IARS(2), INPP5D(1), PDK1(1), PIK3CA(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1), TEC(2), YWHAE(2), YWHAH(1) 3070432 24 5 24 8 5 8 0 4 7 0 0.484 0.950 1.000 285 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), RPE(2), UGDH(1), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1), XYLB(2) 2321377 15 3 15 3 1 6 2 3 3 0 0.282 0.952 1.000 286 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1) 2143527 19 4 19 9 5 6 1 4 3 0 0.798 0.953 1.000 287 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(1), EP300(4), LPL(2), NCOA2(2) 1584940 9 3 9 8 2 1 2 1 3 0 0.984 0.953 1.000 288 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SP1(1) 1811531 19 4 19 4 4 6 2 2 5 0 0.168 0.953 1.000 289 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4) 3881706 40 6 40 6 14 5 4 10 7 0 0.0250 0.955 1.000 290 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(6), CARS2(2), DARS(1), FARS2(2), FARSB(1), GARS(4), IARS(2), KARS(1), LARS2(2), MTFMT(2), NARS2(1), PARS2(1), QARS(1), RARS(1), RARS2(2), SARS2(1), TARS(2), VARS(1), VARS2(1), WARS(2) 4660935 37 12 34 9 8 6 10 5 8 0 0.402 0.955 1.000 291 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGTR2(1), EDN1(1), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1) 1766111 13 2 13 1 2 3 3 1 4 0 0.0547 0.956 1.000 292 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(1) 331945 1 1 1 0 0 0 0 1 0 0 0.797 0.959 1.000 293 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2) 1799275 14 4 14 9 3 5 2 0 4 0 0.824 0.959 1.000 294 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(1), EP300(4), IL7(1), IL7R(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5A(1) 2325064 14 3 14 7 4 3 3 2 2 0 0.771 0.961 1.000 295 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSE(1), CYP11B1(2), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), STS(2), SULT2A1(1), UGT1A1(2), UGT2B15(1), UGT2B4(1) 2348939 17 4 17 6 4 5 3 1 4 0 0.518 0.961 1.000 296 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(2), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(4), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(1), MEF2D(1), NFATC1(4), NFATC2(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), YWHAH(1) 3022915 37 8 36 10 10 8 5 4 10 0 0.193 0.961 1.000 297 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), SDHA(3), SHMT1(1), UQCRFS1(1) 3292756 28 6 28 7 6 6 6 5 4 1 0.298 0.961 1.000 298 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(1), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 1789011 15 3 15 6 3 1 5 2 4 0 0.797 0.962 1.000 299 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), GLB1(1), HEXB(1), LCT(3), MAN2B2(1), MANBA(2), NEU4(1) 1787869 12 4 12 6 5 1 2 0 4 0 0.719 0.962 1.000 300 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(6), FASN(9), MCAT(1) 1413005 20 3 20 4 8 7 2 1 1 1 0.0454 0.963 1.000 301 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), SH3GLB1(1) 2232521 14 4 14 7 2 3 2 3 4 0 0.865 0.963 1.000 302 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(3), DIAPH1(3), GSN(4), HRAS(1), ITGA1(4), MYLK(6), PIK3CA(1), PIK3R1(1), PTK2(3), ROCK1(2), SRC(1), TLN1(7) 3111267 36 6 34 10 8 9 6 5 8 0 0.318 0.963 1.000 303 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(1), CREB1(1), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1) 2570866 9 4 9 9 2 2 1 1 3 0 0.998 0.964 1.000 304 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), APOA4(1), CYP7A1(2), DGAT1(2), HMGCR(1), LPL(2), LRP1(8), SCARB1(1), SOAT1(1) 2356959 20 4 20 5 9 4 3 1 3 0 0.137 0.964 1.000 305 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(2), GNAS(6), GNB1(1), HRAS(1), IGF1R(4), KLK2(1), NGFR(1), PDGFRA(4), RPS6KA1(1), RPS6KA5(1), SOS1(2), SRC(1), STAT3(1) 2896020 26 6 25 7 9 5 5 4 3 0 0.317 0.965 1.000 306 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1), TPI1(2) 333418 4 1 4 0 1 2 0 1 0 0 0.218 0.966 1.000 307 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(6), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), HIBCH(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1) 3412159 28 5 27 5 10 5 3 4 6 0 0.121 0.967 1.000 308 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), OAT(2), PYCR1(1) 1540359 16 3 16 2 4 2 6 2 1 1 0.123 0.967 1.000 309 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(1), CAPNS1(3), EGF(2), EGFR(2), HRAS(1), ITGA1(4), MYLK(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(3), TLN1(7) 2850602 37 4 37 9 12 11 5 4 5 0 0.0644 0.968 1.000 310 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(1), HRAS(1), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3), RELA(1) 2416272 17 3 17 9 4 6 2 2 3 0 0.807 0.968 1.000 311 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 ABO(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1) 4178764 37 8 36 7 15 7 5 4 6 0 0.0299 0.969 1.000 312 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), HAL(1) 1634208 12 3 12 2 3 4 2 1 1 1 0.222 0.969 1.000 313 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(1), DAXX(2), HRAS(1), PML(1), RB1(1), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1) 1585162 14 2 14 5 4 2 4 3 1 0 0.586 0.970 1.000 314 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 CYP1A2(2), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP3A7(3), HSD3B7(2), PLA2G3(2), PLA2G6(3), RDH11(2) 2060711 20 4 20 7 4 2 8 4 2 0 0.651 0.970 1.000 315 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CRHR2(1), ELTD1(4), EMR2(3), GHRHR(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(3), VIPR1(1), VIPR2(1) 2334482 20 5 20 9 5 2 4 6 3 0 0.692 0.970 1.000 316 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(3), ENO1(1), FBP2(1), GAPDHS(1), GCK(1), GOT1(2), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(2), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2) 3654857 33 4 33 8 9 9 6 4 5 0 0.0980 0.971 1.000 317 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TPO(3) 2950561 33 5 33 10 15 4 5 5 4 0 0.240 0.971 1.000 318 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GSK3A(1), GSK3B(1), PFKL(1), PFKM(1), PFKP(1), PLCG1(1), PRKCE(1), PRKCZ(1) 2202973 17 4 17 2 3 7 2 2 3 0 0.0429 0.972 1.000 319 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1), THPO(1) 2575485 14 2 14 5 2 5 2 2 3 0 0.650 0.973 1.000 320 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(6), ATR(5), BRCA1(3), CDC25A(2), CDC25C(2), CDC34(1), EP300(4), MDM2(1), MYT1(6), PRKDC(4), RPS6KA1(1), YWHAH(1) 3545467 36 13 34 10 5 6 6 8 11 0 0.599 0.973 1.000 321 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), GLUD2(1), HAL(1) 1827658 13 3 13 3 3 5 2 1 1 1 0.301 0.974 1.000 322 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(2), CD33(1), CD5(1), IL12B(1), ITGAX(1), TLR2(1), TLR9(6) 1599821 15 2 15 6 5 4 1 4 1 0 0.623 0.974 1.000 323 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(4), AXIN1(3), BTRC(1), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), NOTCH1(5), PSEN1(1), WNT1(1) 1909871 33 4 33 5 12 11 4 5 1 0 0.00870 0.974 1.000 324 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), SOS1(2), SYK(2), VAV1(4) 3715508 40 5 40 9 10 11 6 6 6 1 0.104 0.974 1.000 325 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1D(3), EEF1G(3), EEF2(3), EIF2AK2(1), EIF2AK3(2), EIF2B5(1), EIF4A2(1), EIF4G1(6), EIF4G3(5), EIF5(1), EIF5B(3), KIAA0664(1), PABPC3(4), SLC35A4(2) 3706671 36 6 36 3 6 7 10 7 6 0 0.0115 0.975 1.000 326 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), FARS2(2), GARS(4), IARS(2), KARS(1), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2) 2731777 19 7 18 3 6 4 6 3 0 0 0.127 0.975 1.000 327 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG7(2), GABARAPL1(1), IFNA10(1), IFNA16(1), PIK3C3(2), PIK3R4(3), PRKAA2(1), ULK1(2), ULK3(1) 1834852 15 3 15 4 3 3 1 5 3 0 0.445 0.977 1.000 328 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), PIGW(1) 2070293 16 4 16 3 5 3 2 4 2 0 0.146 0.977 1.000 329 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 18 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), PDE6B(3), PDE6C(1), TF(1) 2846295 25 4 25 8 9 4 5 2 5 0 0.474 0.978 1.000 330 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(2), AOC2(1), AOC3(2), DDHD1(2), ESCO1(4), ESCO2(1), PLA1A(1), SH3GLB1(1) 2177920 14 5 14 6 5 4 0 3 2 0 0.637 0.979 1.000 331 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(2), HMGCS2(1), HSD17B4(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 3716060 34 5 33 4 7 6 7 4 10 0 0.0299 0.979 1.000 332 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), IARS(2), IL4R(1), INPP5D(1), JAK2(2), JAK3(3), PIK3CA(1), SOS1(2), SOS2(1), SRC(1), STAT6(1), TYK2(1) 3198496 18 3 18 7 5 3 2 4 4 0 0.673 0.980 1.000 333 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(1), UGCG(1) 2117481 14 3 14 6 5 3 1 1 4 0 0.528 0.980 1.000 334 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(1), HDAC5(1), MEF2A(1), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(1), YWHAH(1) 1762435 13 3 13 2 2 3 2 2 4 0 0.205 0.980 1.000 335 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(2), TYR(2) 401517 4 1 4 1 1 0 2 1 0 0 0.641 0.981 1.000 336 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1) 417598 1 1 1 0 0 0 1 0 0 0 0.825 0.982 1.000 337 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), HSD3B7(2), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB4(2), PFKL(1), PFKM(1), PFKP(1), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1) 3245551 33 8 33 9 10 6 11 3 3 0 0.180 0.982 1.000 338 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(1), UGP2(2) 422587 3 2 3 2 0 1 0 2 0 0 0.920 0.982 1.000 339 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(2), APC(4), AXIN1(3), AXIN2(1), CTNNB1(6), DACT1(2), DKK2(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(8), MVP(2), NKD1(3), PSEN1(1), SENP2(1), SFRP1(2), WIF1(1) 3547564 44 10 44 13 18 10 6 6 4 0 0.184 0.982 1.000 340 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(8), ATM(6), ATR(5), CCNA1(2), CCNE1(1), CDC25A(2), CDK4(2), DHFR(1), GSK3B(1), RB1(1), TGFB1(1), TGFB2(2) 2480456 32 9 29 10 4 5 10 3 10 0 0.749 0.983 1.000 341 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(1), ALDH3A1(1), CYP2C19(3), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), HADHA(1), SH3GLB1(1) 2661758 15 4 15 8 3 2 3 3 4 0 0.894 0.983 1.000 342 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2) 480194 8 1 8 3 4 2 1 1 0 0 0.595 0.985 1.000 343 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), RASA1(1), RELA(1), SOS1(2), VAV1(4), ZAP70(4) 4037743 41 5 41 8 9 11 7 6 7 1 0.0588 0.986 1.000 344 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PDGFRA(4), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1) 3013300 21 2 21 7 4 4 5 5 3 0 0.629 0.987 1.000 345 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 HSD3B7(2), RDH11(2) 417291 4 1 4 0 1 0 2 1 0 0 0.349 0.988 1.000 346 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), CEL(4), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), GK(2), GK2(3), GLB1(1), GPAM(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2) 5109698 60 9 57 20 25 7 9 8 11 0 0.274 0.988 1.000 347 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(1), ALG12(2), ALG5(1), ALG9(2), B4GALT2(1), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), ST6GAL1(1) 3699321 27 7 26 6 8 7 3 4 5 0 0.187 0.988 1.000 348 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 71 ACTN1(1), ACTN2(4), ACTN3(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(1), CSNK2A1(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), EGFR(2), EP300(4), ERBB2(5), FARP2(1), FER(6), IGF1R(4), INSR(4), IQGAP1(1), LEF1(2), LMO7(5), MAP3K7(2), MET(4), MLLT4(3), NLK(1), PARD3(3), PTPN6(4), PTPRB(8), PTPRF(6), PTPRJ(1), PTPRM(5), PVRL2(1), PVRL4(2), RAC2(1), SORBS1(1), SRC(1), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(1), TGFBR1(2), TGFBR2(4), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASL(2), YES1(1) 9939555 127 18 122 24 33 28 21 22 21 2 0.00346 0.988 1.000 349 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), GNAI1(1), GNAQ(1), GNAS(6), GNB1(1), HRAS(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3052937 37 7 36 8 13 10 4 4 6 0 0.0790 0.989 1.000 350 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1) 3231479 21 2 21 7 2 6 4 5 4 0 0.588 0.990 1.000 351 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(1), CCKBR(2), CELSR1(3), CELSR2(4), CELSR3(10), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(1), GPR132(1), GPR133(6), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GPR77(1), GRM1(7), GRPR(1), LGR6(1), LPHN2(3), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(1), TSHR(3) 5757526 66 15 64 21 23 12 13 9 8 1 0.118 0.991 1.000 352 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(2), BLVRA(2), CP(5), CPOX(1), FTMT(2), PPOX(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 3618032 21 6 21 5 2 8 1 3 7 0 0.292 0.991 1.000 353 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), PON1(1) 2532477 32 5 31 10 12 4 7 3 6 0 0.304 0.992 1.000 354 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 431242 1 1 1 1 1 0 0 0 0 0 0.845 0.992 1.000 355 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 GNAQ(1), GNAS(6), GNB1(1), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PTK2(3), ROCK2(1) 2127312 17 4 16 8 5 4 3 2 3 0 0.852 0.993 1.000 356 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(8), ATM(6), BUB1(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), E2F3(3), E2F4(3), E2F5(2), EP300(4), ESPL1(3), GSK3B(1), HDAC4(2), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(2), PRKDC(4), RB1(1), RBL1(1), TBC1D8(2), TGFB1(1) 9322259 91 16 88 16 20 13 21 18 18 1 0.0192 0.993 1.000 357 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(1), SP1(1) 570349 3 1 3 0 1 0 2 0 0 0 0.547 0.993 1.000 358 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2RL1(1), F2RL2(1), F2RL3(1), MAPK7(4), MAPK8(1), MYEF2(1), PLD2(2), PLD3(1), PTK2(3), RASAL1(2), SRC(1), TEC(2), VAV1(4) 2392343 27 2 27 7 8 8 4 2 4 1 0.137 0.994 1.000 359 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SOS1(2), SYK(2), VAV1(4) 3304651 32 4 32 8 8 9 3 5 6 1 0.154 0.994 1.000 360 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(1), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2) 4307592 39 9 38 12 11 9 6 6 7 0 0.380 0.994 1.000 361 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(3), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CRADD(2), DAXX(2), GSN(4), LMNB1(1), LMNB2(1), MAP2K7(2), MAP3K1(3), MAPK8(1), MDM2(1), NFKBIA(2), NUMA1(3), PAK2(2), PRKCD(2), PRKDC(4), PSEN1(1), PSEN2(1), PTK2(3), RASA1(1), RB1(1), RELA(1), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 6016557 57 12 55 16 13 9 15 7 13 0 0.293 0.994 1.000 362 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(5), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), NOS1(5), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2230541 35 8 32 10 10 5 6 6 8 0 0.346 0.994 1.000 363 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), AOC2(1), AOC3(2), ESD(1) 517108 6 1 6 2 3 2 1 0 0 0 0.471 0.995 1.000 364 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ALDH18A1(1), ALDH1A3(1), ALDH3A1(1), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CPS1(4), SAT2(1) 2561750 15 2 15 4 6 3 3 1 1 1 0.307 0.995 1.000 365 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), BCL2L1(3), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CRADD(2), DAXX(2), FAS(1), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(3), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 3793759 41 9 39 12 11 9 8 3 10 0 0.475 0.995 1.000 366 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), CEL(4), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GK(2), GLB1(1), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2) 4208418 51 9 48 18 22 5 7 6 11 0 0.365 0.995 1.000 367 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(1), FUT6(1) 441507 3 1 3 1 3 0 0 0 0 0 0.595 0.995 1.000 368 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(6), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PCK2(3), PDHA1(1), PKLR(1) 4025805 40 6 40 11 12 13 2 3 9 1 0.176 0.996 1.000 369 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(2), TNFRSF10B(2), TRADD(1), TRAF2(1) 2918040 23 4 23 7 7 5 4 2 5 0 0.346 0.996 1.000 370 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), ASAH1(1), BRAF(1), DAG1(2), DRD2(1), EGFR(2), EPHB2(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), SOS1(2), SOS2(1), SRC(1), STAT3(1), TERF2IP(1) 5080553 43 8 43 9 10 6 6 10 11 0 0.149 0.996 1.000 371 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(1), GCNT2(1), ST8SIA1(2) 538356 5 1 5 1 3 1 1 0 0 0 0.347 0.997 1.000 372 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNGR1(1), JAK2(2), STAT1(1) 644179 4 1 4 2 0 0 2 1 1 0 0.838 0.997 1.000 373 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), RIPK3(2) 4239635 38 11 36 12 10 6 6 3 13 0 0.564 0.997 1.000 374 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(2), LDHB(1) 588488 3 1 3 0 1 0 1 1 0 0 0.455 0.997 1.000 375 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(3), BAD(1), BAK1(1), BCL2L1(3), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CHUK(1), FAS(1), FASLG(1), HELLS(1), IKBKB(2), IRF1(1), IRF3(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), NFKBIE(1), PRF1(3), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 4960070 53 13 50 12 9 10 11 7 15 1 0.211 0.997 1.000 376 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(3), BAK1(1), BCL2L1(3), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), FAS(1), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 3183025 35 9 32 12 7 5 9 4 10 0 0.676 0.997 1.000 377 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), CAMK1G(1), FPR1(1), GNA15(1), GNB1(1), HRAS(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PAK1(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RELA(1) 3332326 35 7 33 11 6 7 11 4 7 0 0.560 0.998 1.000 378 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(4), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), RYR1(13) 3996897 43 8 43 13 16 2 9 7 9 0 0.384 0.998 1.000 379 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(1), GAL3ST1(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SGMS1(1), SGPP1(1), SMPD3(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGCG(1) 3137733 20 3 20 9 7 4 1 5 3 0 0.538 0.998 1.000 380 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC1(3), RPA1(1), RPA2(1), RPA3(2), RPS27A(1) 4381152 38 8 38 7 11 6 7 6 7 1 0.0701 0.998 1.000 381 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT3(3), AGPAT4(3), CDIPT(1), CHAT(3), CPT1B(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GPD1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLCB2(3), PLCG1(1), PLCG2(4), PPAP2B(2) 4382186 48 7 48 10 18 5 10 7 8 0 0.0589 0.998 1.000 382 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(4), AXIN1(3), CCND2(1), CCND3(1), CSNK1E(1), CTNNB1(6), DVL1(4), DVL2(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(3), PPP2R5C(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), SFRP4(1), TCF7(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT5B(1), WNT7A(1), WNT7B(2) 5276583 66 18 64 19 23 18 5 10 10 0 0.0792 0.998 1.000 383 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), CARM1(1), FTCD(2), HAL(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), PRPS1(1), UROC1(2) 3430693 24 4 24 9 7 8 6 1 2 0 0.426 0.998 1.000 384 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), GCDH(2), HADHA(1) 671418 5 1 5 0 1 1 2 0 1 0 0.248 0.998 1.000 385 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GLUD2(1), GOT1(2), LAP3(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), PYCR2(1), RARS(1), RARS2(2) 3126095 48 8 48 10 12 9 13 6 7 1 0.0936 0.998 1.000 386 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(4), POLH(1), POLI(1), POLL(2), POLM(1), POLQ(2), REV1(1), REV3L(3) 3517802 27 4 27 5 6 6 5 6 4 0 0.145 0.999 1.000 387 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CDK4(2), MDM2(1), NXT1(1) 610899 5 1 5 0 3 0 2 0 0 0 0.210 0.999 1.000 388 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 3100288 29 4 29 3 5 8 6 3 7 0 0.0212 0.999 1.000 389 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(1), HSD17B2(1), HSD17B4(2), HSD3B1(2) 696129 7 1 7 3 1 3 2 1 0 0 0.636 0.999 1.000 390 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), HADHA(1), HADHB(2) 718327 6 1 6 0 0 2 1 0 3 0 0.187 0.999 1.000 391 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), AR(1), ESR1(1), ESR2(1), ESRRA(1), NR0B1(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(1), NR4A2(3), PGR(3), PPARA(1), PPARD(1), RARB(1), RARG(2), ROR1(2), RORA(1), RORC(1) 3702002 34 4 34 11 9 8 6 5 6 0 0.255 0.999 1.000 392 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD4(2), LCK(1), PTPRC(2), ZAP70(4) 678897 9 1 9 2 2 2 1 2 2 0 0.368 0.999 1.000 393 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(6), CCNA1(2), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(2), GBA2(3), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYT1(6), POLA2(1), POLE(6), POLE2(1), RB1(1), RBL1(1), RPA1(1), RPA2(1), RPA3(2), TFDP2(1), TNXB(6) 6602784 73 14 72 17 19 11 14 16 12 1 0.0593 0.999 1.000 394 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGTR2(1), CAMK2D(1), CDK5(1), GNA11(2), GNAI1(1), GNB1(1), HRAS(1), JAK2(2), MAPK8(1), MAPT(1), MYLK(6), PLCG1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1) 3499349 24 3 24 9 5 6 5 4 4 0 0.574 0.999 1.000 395 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 C1QA(1), C1QC(1), C1S(4), C3(5), C3AR1(2), C6(3), C7(3), C8A(3), C9(1), CD55(1), CD59(1), CFB(4), CFH(3), CFI(1), CR1(2), CR2(4), F10(4), F12(1), F13A1(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), MASP1(1), PLAT(1), PLAU(3), PLAUR(2), PROC(1), PROS1(1), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), TFPI(2), THBD(2), VWF(4) 7802629 85 15 83 19 17 18 22 15 13 0 0.0597 0.999 1.000 396 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(1), HADHB(2), HSD17B4(2), PPT2(2) 731370 7 1 7 0 1 1 1 2 2 0 0.122 0.999 1.000 397 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(2), CYP2A7(1), NAT2(1), XDH(4) 680285 10 2 10 5 5 1 0 2 2 0 0.761 0.999 1.000 398 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1) 712970 5 2 5 2 0 1 2 1 1 0 0.774 0.999 1.000 399 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(1), FBXW7(3), RB1(1) 717348 7 2 7 3 1 3 1 2 0 0 0.716 0.999 1.000 400 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(6), GNB1(1), PRKAR1A(1) 585170 11 3 10 2 5 3 2 1 0 0 0.259 0.999 1.000 401 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT3(3), AGPAT4(3), CDIPT(1), CHAT(3), CHPT1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), ESCO1(4), ESCO2(1), ETNK2(1), GPAM(3), GPD1(1), LYPLA2(1), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2), PTDSS1(2), SH3GLB1(1) 5736042 51 11 51 16 18 6 9 8 10 0 0.320 0.999 1.000 402 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), CPO(2), HBB(1) 702436 5 3 5 2 2 1 1 0 1 0 0.624 0.999 1.000 403 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(6), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX4I2(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(2), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRC2(1), UQCRFS1(1) 4850391 51 10 50 16 10 10 9 9 12 1 0.435 0.999 1.000 404 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(2), BCR(1), BTK(1), CD19(1), DAPP1(1), FLOT1(1), FLOT2(1), ITPR1(5), ITPR2(3), ITPR3(6), PDK1(1), PHF11(1), PIK3CA(1), PLCG2(4), PREX1(4), PTEN(1), PTPRC(2), RPS6KA1(1), RPS6KA2(1), SYK(2), TEC(2), VAV1(4) 4753696 46 7 46 13 16 8 5 9 7 1 0.214 0.999 1.000 405 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(8), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), ATM(6), ATR(5), BUB1(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK7(1), CREBBP(1), CUL1(1), E2F3(3), EP300(4), ESPL1(3), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PKMYT1(2), PRKDC(4), RB1(1), RBL1(1), RBL2(2), SKP1(1), SMC1A(1), SMC1B(1), TGFB1(1), TGFB2(2), YWHAE(2), YWHAH(1) 11554067 103 18 99 25 20 19 25 14 24 1 0.153 0.999 1.000 406 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(6), CACNA1B(6), GNAS(6), GNB1(1), GNB3(1), GRM4(1), ITPR3(6), KCNB1(3), PLCB2(3), PRKACG(2), SCNN1A(2), SCNN1B(1), TAS1R1(5), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R41(1), TAS2R42(1), TAS2R60(1), TAS2R9(1), TRPM5(1) 5040792 65 12 61 15 22 10 13 6 14 0 0.0270 0.999 1.000 407 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2D(1), YWHAH(1) 684413 8 1 8 1 0 2 3 1 2 0 0.352 0.999 1.000 408 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(3), PDHA1(1), SLC18A3(1) 613068 7 3 7 3 4 0 3 0 0 0 0.668 0.999 1.000 409 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), ASH2L(2), C17orf79(1), CARM1(1), DOT1L(1), EED(2), EHMT1(3), EHMT2(2), EZH2(3), FBXO11(1), HCFC1(2), KDM6A(1), MEN1(2), MLL(2), MLL2(13), MLL3(15), MLL5(1), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(3), PRMT6(1), PRMT8(1), SATB1(5), SETD1A(3), SETD2(3), SETD8(1), SETDB1(1), SUV39H2(2), SUV420H1(3), SUV420H2(2), WHSC1(1), WHSC1L1(1) 10401201 94 21 91 24 11 19 22 18 24 0 0.327 0.999 1.000 410 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(2), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(3) 735587 12 1 12 2 2 2 5 3 0 0 0.288 0.999 1.000 411 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH3A1(1), UGDH(1) 739390 3 1 3 2 2 0 0 1 0 0 0.852 0.999 1.000 412 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD14(2), CD19(1), CD1A(1), CD1B(3), CD1C(1), CD1E(1), CD2(2), CD22(1), CD33(1), CD38(1), CD4(2), CD44(3), CD5(1), CD55(1), CD59(1), CR1(2), CR2(4), CSF1(1), CSF1R(3), CSF3R(1), DNTT(1), EPOR(2), FCGR1A(1), FLT3(3), GP9(2), IL1B(1), IL1R2(2), IL2RA(1), IL4R(1), IL6(2), IL7(1), IL7R(1), ITGA1(4), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(3), MME(2), MS4A1(2), THPO(1), TPO(3) 7057307 72 15 71 21 13 14 14 18 13 0 0.278 0.999 1.000 413 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(2), LARS2(2), PDHA1(1) 856918 7 3 7 2 3 2 0 2 0 0 0.521 1.000 1.000 414 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL6(2) 850791 3 2 3 2 0 1 2 0 0 0 0.831 1.000 1.000 415 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(4), AR(1), ASAH1(1), BRAF(1), CAMP(2), DAG1(2), EGFR(2), GNA11(2), GNA15(1), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(1), PIK3CD(1), PIK3R1(1), SRC(1) 4656160 45 9 45 13 13 4 7 8 13 0 0.385 1.000 1.000 416 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(6), PSEN1(1) 782094 10 2 10 2 1 5 1 2 1 0 0.317 1.000 1.000 417 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCBP2(1), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CCR9(1), CCRL1(1), CCRL2(2), CHML(3), CHRM2(3), CHRM3(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(1), GPR77(1), GPR83(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), MC3R(2), MC5R(1), MLNR(1), MTNR1A(1), NMUR2(2), NPY1R(1), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRL1(2), OPRM1(1), OR1C1(2), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(1), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), SSTR1(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(1) 10547887 130 21 128 34 40 16 42 23 9 0 0.00815 1.000 1.000 418 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH4A1(3), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GOT1(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1) 3843113 48 7 48 10 16 10 11 5 5 1 0.0387 1.000 1.000 419 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(2), BLNK(1), BTK(1), CARD11(2), CD19(1), CD22(1), CHUK(1), CR2(4), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), LILRB3(1), MALT1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC2(1), SYK(2), VAV1(4), VAV3(1) 6155182 69 15 69 20 16 20 7 10 15 1 0.144 1.000 1.000 420 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), AKT1(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(1), EDN1(1), ELSPBP1(1), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(1), MYH2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 4392482 46 7 46 12 16 10 7 4 9 0 0.0961 1.000 1.000 421 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NOX1(2), RELA(1), SOD1(1), XDH(4) 859903 8 1 8 6 2 2 2 1 1 0 0.946 1.000 1.000 422 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), WDR1(2) 846622 11 2 11 3 3 2 0 5 1 0 0.355 1.000 1.000 423 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), APAF1(3), ATM(6), BAD(1), BCL2L1(3), BIRC2(1), CAPN1(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK4(1), NFKBIA(2), NTRK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 7221369 66 13 64 18 19 15 8 9 15 0 0.172 1.000 1.000 424 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK2(2), TYK2(1) 899255 4 1 4 1 1 0 1 1 1 0 0.579 1.000 1.000 425 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK2(2), TYK2(1) 899255 4 1 4 1 1 0 1 1 1 0 0.579 1.000 1.000 426 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), CASP8(2), CCL3(1), CD14(2), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(2), IRAK4(1), IRF3(1), IRF7(1), LY96(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(2), TLR2(1), TLR3(2), TLR5(2), TLR6(2), TLR8(1), TLR9(6) 7775663 75 15 73 20 15 16 18 8 18 0 0.161 1.000 1.000 427 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), STAT1(1), STAT2(1), TYK2(1) 934636 7 1 7 2 3 0 2 2 0 0 0.527 1.000 1.000 428 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 87 ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(1), AMH(1), AMHR2(5), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BMPR1A(3), BMPR2(1), CHRD(2), COMP(2), CREBBP(1), CUL1(1), E2F4(3), E2F5(2), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2R1A(1), PPP2R1B(2), RBL1(1), RBL2(2), ROCK1(2), ROCK2(1), SKP1(1), SMAD7(1), SMAD9(1), SP1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), THBS1(1), THBS2(4), ZFYVE16(4), ZFYVE9(3) 8371851 78 12 77 19 21 16 14 15 12 0 0.0757 1.000 1.000 429 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AKR1C3(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2F1(1), CYP2S1(2), CYP3A7(3), EPHX1(2), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 4949750 51 7 50 15 13 13 11 6 8 0 0.213 1.000 1.000 430 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), ICAM1(1), ITGB2(1), PTPRC(2) 920880 6 1 6 0 2 1 0 2 1 0 0.108 1.000 1.000 431 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1) 992396 6 1 6 1 1 2 1 0 2 0 0.410 1.000 1.000 432 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2) 875586 6 1 6 1 3 1 1 0 1 0 0.288 1.000 1.000 433 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(2), IFNAR2(2), MAPK8(1), RELA(1), TNFRSF11A(2) 959360 9 1 9 2 1 2 2 3 1 0 0.419 1.000 1.000 434 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(6), GNB1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 851958 14 3 13 2 8 3 3 0 0 0 0.138 1.000 1.000 435 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD4(2), ICAM1(1), ITGB2(1), PTPRC(2) 965985 8 1 8 1 2 1 0 3 2 0 0.261 1.000 1.000 436 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(1), CR2(4), CSK(1), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP4K1(2), NFATC1(4), NFATC2(4), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPRC(2), SOS1(2), SOS2(1), SYK(2), VAV1(4) 6415944 65 11 65 18 20 17 5 8 14 1 0.0937 1.000 1.000 437 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(2), CARD11(2), CBL(2), CBLB(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(1), HRAS(1), IKBKB(2), ITK(1), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), SOS1(2), SOS2(1), TEC(2), VAV1(4), VAV3(1), ZAP70(4) 8391871 89 15 88 27 24 23 10 11 20 1 0.192 1.000 1.000 438 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2) 928258 6 1 6 1 3 1 1 0 1 0 0.281 1.000 1.000 439 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(2), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(2), NOD1(3), PAK1(2), PLCG1(1), PLCG2(4), PTPRZ1(2), RELA(1), SRC(1), TCIRG1(1), TJP1(4) 6080698 57 8 56 16 8 14 15 11 9 0 0.263 1.000 1.000 440 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(2), CSK(1), DAG1(2), EPHB2(1), FBXW7(3), GRAP2(1), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), SOS1(2), SOS2(1), VAV1(4), ZAP70(4) 4616773 45 7 44 10 13 10 6 7 8 1 0.122 1.000 1.000 441 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(1), IL6(2), STAT1(1), STAT3(1), STAT5A(1) 1046991 8 2 8 2 3 2 3 0 0 0 0.321 1.000 1.000 442 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BAD(1), CABIN1(2), CAMK4(2), CREBBP(1), CSNK2A1(1), EGR3(1), EP300(4), FCER1A(1), GATA3(1), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(2), ITK(1), KPNA5(1), MAP2K7(2), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4), VAV3(1) 7647962 74 15 73 24 24 18 10 6 15 1 0.298 1.000 1.000 443 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(2), HGS(2), TF(1) 1102888 10 1 10 0 1 4 2 2 1 0 0.0349 1.000 1.000 444 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A3(1), ALDH3A1(1), HADHA(1) 1050345 3 1 3 2 2 0 1 0 0 0 0.854 1.000 1.000 445 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(2), JAK3(3), STAT3(1), TYK2(1) 1028013 7 1 7 5 2 2 2 0 1 0 0.869 1.000 1.000 446 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(2), ABCA10(1), ABCA12(9), ABCA13(7), ABCA2(5), ABCA3(4), ABCA4(5), ABCA5(3), ABCA6(3), ABCA7(3), ABCA8(6), ABCA9(7), ABCB1(2), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(4), ABCB6(1), ABCC10(1), ABCC11(2), ABCC3(2), ABCC4(3), ABCC5(2), ABCC6(1), ABCC9(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(2), TAP1(1) 9980845 95 14 93 29 20 22 16 23 14 0 0.149 1.000 1.000 447 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1B(2), ACVR2A(2), AMH(1), AMHR2(5), BMP2(1), BMP7(1), BMPR1A(3), BMPR2(1), CCL1(2), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR4(2), CCR7(1), CCR9(1), CSF1(1), CSF1R(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT4(8), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), IFNK(1), IL10RA(1), IL12B(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1R2(2), IL1RAP(2), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL4R(1), IL6(2), IL6ST(2), IL7(1), IL7R(1), INHBA(1), INHBC(1), KDR(1), KIT(3), LIF(2), LIFR(4), MET(4), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(2), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFSF14(1), TNFSF8(3), TPO(3), TSLP(1), XCR1(1) 15216541 161 26 159 33 45 38 29 29 20 0 0.000120 1.000 1.000 448 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1) 1143416 11 1 11 5 6 3 1 1 0 0 0.648 1.000 1.000 449 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), PRKAA2(1), PRKAB1(1), PRKAB2(1) 1236763 7 1 7 0 0 3 0 1 3 0 0.0939 1.000 1.000 450 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLD1(1), POLG(4), RRM1(1) 1111876 12 3 12 2 3 5 0 1 3 0 0.0994 1.000 1.000 451 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5E(1), NT5M(1) 1254091 13 1 13 3 4 3 2 2 2 0 0.270 1.000 1.000 452 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(8), ABL2(1), AKT1(2), ARAF(1), BAD(1), BRAF(1), CAMK2D(1), CBL(2), CBLB(1), CRK(1), EGF(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GSK3B(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK9(1), NCK1(3), NCK2(2), NRG1(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SRC(1), STAT5A(1) 8932933 90 15 88 22 24 21 13 10 22 0 0.0616 1.000 1.000 453 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AK3(1), CAD(4), CTPS2(1), DPYD(3), DPYS(4), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), NME4(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(1) 7016629 61 9 60 19 17 11 12 13 8 0 0.301 1.000 1.000 454 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), APOA5(1), CPT1B(3), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A22(1), CYP7A1(2), CYP8B1(1), FABP4(1), GK(2), GK2(3), HMGCS2(1), LPL(2), ME1(2), MMP1(1), NR1H3(2), PCK1(2), PCK2(3), PLTP(1), PPARA(1), PPARD(1), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SORBS1(1) 5504739 50 6 50 12 13 15 10 4 7 1 0.0338 1.000 1.000 455 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD4(2), IL12B(1), JAK2(2), TYK2(1) 1279067 8 1 8 2 2 1 1 2 2 0 0.512 1.000 1.000 456 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(1), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TRAF2(1), TRAF5(1) 1263435 7 1 7 3 1 1 3 0 2 0 0.763 1.000 1.000 457 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK2(2), JAK3(3), PIAS1(1), PIAS3(1), PTPRU(6), SOAT1(1) 1197602 14 4 14 8 6 3 4 0 1 0 0.842 1.000 1.000 458 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), ST3GAL1(2) 1233267 9 1 9 4 2 3 3 0 1 0 0.657 1.000 1.000 459 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), DRD2(1), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(6), GRM1(7), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), HRAS(1), HTR2A(1), HTR2B(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP3K2(2), MAPK7(4), NPR1(1), NPR2(1), PDGFC(1), PDGFRA(4), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), PRKG1(1), PRKG2(1), SOS1(2), SOS2(1), SRC(1), TJP1(4), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 11466660 128 16 125 30 42 24 23 22 17 0 0.00512 1.000 1.000 460 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 1297934 10 2 10 2 2 2 4 1 1 0 0.336 1.000 1.000 461 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 1297934 10 2 10 2 2 2 4 1 1 0 0.336 1.000 1.000 462 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 1297934 10 2 10 2 2 2 4 1 1 0 0.336 1.000 1.000 463 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1) 1338118 6 2 6 3 1 1 3 1 0 0 0.882 1.000 1.000 464 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), HADHA(1), SCP2(1) 1447120 9 1 9 0 3 3 2 0 1 0 0.0474 1.000 1.000 465 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1) 1381211 11 2 11 3 2 2 5 1 1 0 0.447 1.000 1.000 466 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), JAK2(2), JAK3(3), PIAS3(1), PTPRU(6), SRC(1), STAT3(1) 1329354 16 4 16 8 5 5 5 0 1 0 0.717 1.000 1.000 467 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), HLA-A(2), HRAS(1), ICAM1(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), ITGB2(1), KIR2DL1(1), KIR3DL2(1), KLRC1(1), KLRC2(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(3), PTPN6(4), RAC2(1), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), VAV3(1), ZAP70(4) 9332162 88 13 86 24 25 20 10 14 18 1 0.0619 1.000 1.000 468 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(3), GNAS(6), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(1) 1309940 20 4 19 4 8 3 4 5 0 0 0.205 1.000 1.000 469 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADSL(1), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ENPP3(2), ENTPD2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PFAS(5), PKLR(1), POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1) 11157206 106 12 106 26 35 26 18 13 12 2 0.00823 1.000 1.000 470 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1) 1318200 10 2 10 8 5 0 2 1 2 0 0.959 1.000 1.000 471 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(6), GNB1(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1343789 19 3 18 2 8 5 3 1 2 0 0.0356 1.000 1.000 472 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(1), RELA(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(1) 1467866 14 2 14 6 3 2 5 2 2 0 0.712 1.000 1.000 473 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2) 1452002 16 2 16 2 5 4 3 1 3 0 0.0815 1.000 1.000 474 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), ATIC(1), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(3), TYMS(1) 1533771 15 2 15 5 2 2 4 3 4 0 0.534 1.000 1.000 475 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1) 1571953 12 2 12 5 0 4 5 2 1 0 0.766 1.000 1.000 476 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(8), ACTN1(1), AKT1(2), ARHGEF6(1), ARHGEF7(2), BCAR1(2), BRAF(1), CDC42(1), CRK(1), CSE1L(1), DOCK1(2), EPHB2(1), GRB7(1), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PKLR(1), PLCG1(1), PLCG2(4), PTEN(1), PTK2(3), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), SRC(1), TERF2IP(1), TLN1(7), TLN2(1), ZYX(1) 10515770 95 13 92 28 21 19 17 19 19 0 0.249 1.000 1.000 477 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 16 CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(1), NFKBIA(2), RELA(1), TRAF2(1) 1605781 11 2 11 3 1 2 4 2 2 0 0.583 1.000 1.000 478 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), HRAS(1), JAK2(2), PTPN6(4), SOS1(2), STAT5A(1) 1523724 11 2 11 3 3 1 3 3 1 0 0.515 1.000 1.000 479 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(2), ILVBL(2), LARS2(2), PDHA1(1), VARS(1), VARS2(1) 1604132 12 3 12 4 5 3 1 2 1 0 0.587 1.000 1.000 480 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2) 1559796 20 2 20 3 1 6 8 3 2 0 0.105 1.000 1.000 481 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), JAK2(2), JAK3(3), STAT1(1), STAT3(1), STAT5A(1), TYK2(1) 1607144 10 1 10 6 4 2 3 0 1 0 0.792 1.000 1.000 482 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), CSK(1), CTNNA1(3), CTNNA2(3), CTNNB1(6), PTK2(3), SRC(1), VCL(1) 1683706 26 3 26 6 11 8 1 4 2 0 0.0693 1.000 1.000 483 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2) 1740531 18 2 18 3 1 5 8 2 2 0 0.161 1.000 1.000 484 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1) 1943717 14 2 14 7 1 4 6 2 1 0 0.839 1.000 1.000 485 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(1), PLCG1(1), PTPN6(4), SOS1(2), STAT5A(1) 1868758 15 2 15 5 5 2 3 2 3 0 0.583 1.000 1.000 486 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(5), HS2ST1(1), HS3ST2(3), HS6ST1(2), NDST1(2), NDST3(3), NDST4(2) 1822610 26 3 26 7 11 3 8 2 2 0 0.232 1.000 1.000 487 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(1), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 1949524 15 4 15 6 3 3 5 2 2 0 0.690 1.000 1.000 488 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1) 2008371 11 2 11 7 5 2 2 1 1 0 0.881 1.000 1.000 489 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(2), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(2), CAPN5(2), CAPN7(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), GIT2(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAM(1), ITGAV(2), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(4), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PIK3R2(2), PTK2(3), RAC2(1), RAP1B(1), ROCK1(2), ROCK2(1), SDCCAG8(1), SEPP1(1), SORBS1(1), SOS1(2), SRC(1), TLN1(7), TNS1(3), VAV3(1), VCL(1), ZYX(1) 11616358 98 14 96 27 22 24 23 14 15 0 0.0497 1.000 1.000 490 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(1), HRAS(1), ITGA1(4), PLCB1(1), PTK2(3), SRC(1), SYK(2), TBXAS1(1) 2102026 16 1 16 5 4 4 2 4 2 0 0.556 1.000 1.000 491 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), RPL10A(1), RPL10L(1), RPL18A(1), RPL22L1(1), RPL24(1), RPL35(1), RPL3L(2), RPS11(2), RPS28(1), RPSA(2) 1961250 14 2 14 4 6 1 3 0 4 0 0.602 1.000 1.000 492 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(2), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP4K2(2), MAPK8(1), NFKBIA(2), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 2120966 26 3 25 6 7 4 9 3 3 0 0.215 1.000 1.000 493 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK3(3), LCK(1), MAPK8(1), SOS1(2), STAT5A(1), SYK(2) 2048680 15 2 15 9 6 4 1 2 2 0 0.875 1.000 1.000 494 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK3(1), COL2A1(3), CPSF1(3), CPSF2(4), CPSF3(2), CPSF4(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(2), DHX16(3), DHX38(1), DHX8(1), DHX9(2), DICER1(5), FUS(1), LOC440563(2), METTL3(1), NCBP2(1), NONO(1), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(2), PRPF8(2), PTBP1(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B5(1), SNRPB(1), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(2), U2AF1(1), U2AF2(2), XRN2(3) 9144379 70 19 68 19 17 11 9 13 19 1 0.364 1.000 1.000 495 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD4(2), CREBBP(1), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4) 2012567 27 4 26 5 11 6 5 3 2 0 0.0667 1.000 1.000 496 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD4(2), CREBBP(1), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4) 2012567 27 4 26 5 11 6 5 3 2 0 0.0667 1.000 1.000 497 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 238 ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2B(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CALCR(1), CCKAR(5), CCKBR(2), CGA(1), CHRM2(3), CHRM3(1), CHRM5(3), CRHR2(1), CTSG(1), CYSLTR2(1), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), FSHR(1), GABBR1(5), GABBR2(1), GABRA4(5), GABRA5(3), GABRA6(1), GABRB1(2), GABRB3(3), GABRD(1), GABRE(1), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GLP2R(3), GLRA2(2), GNRHR(1), GPR83(2), GRIA1(1), GRID1(5), GRID2(2), GRIK2(2), GRIK3(1), GRIK5(1), GRIN1(5), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(7), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM6(4), GRM7(4), GRM8(2), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), LTB4R2(1), MC2R(2), MC3R(2), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMUR2(2), NPBWR1(1), NPFFR2(1), NPY1R(1), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(1), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(2), PRSS1(2), PTGDR(2), PTGFR(1), RXFP1(1), SSTR1(2), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(1), TAAR5(1), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TRHR(1), TRPV1(2), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 19336480 245 23 235 70 71 40 57 41 35 1 0.00617 1.000 1.000 498 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1) 2847780 20 1 20 2 4 5 3 5 3 0 0.0577 1.000 1.000 499 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), OGT(1), ST3GAL1(2) 2777876 20 2 20 9 5 5 4 3 3 0 0.711 1.000 1.000 500 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADSL(1), ADSS(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), GMPR(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), IMPDH1(2), IMPDH2(1), NME4(1), NPR1(1), NPR2(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT9(2), PAICS(2), PAPSS1(2), PAPSS2(3), PDE10A(5), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(1), PFAS(5), PKLR(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(4) 14179438 130 17 128 35 45 24 19 24 16 2 0.0320 1.000 1.000 501 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(5), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1C2(1), ATP6V1F(1), GNAS(6), PDIA4(1), PLCG1(1), PLCG2(4), SEC61A1(1), SEC61A2(2), SEC61G(1) 3201148 36 5 35 10 12 8 9 5 2 0 0.211 1.000 1.000 502 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(1), CCND2(1), CCND3(1), CDC42(1), CHAD(1), COL11A1(4), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), CRK(1), CTNNB1(6), DIAPH1(3), DOCK1(2), EGF(2), EGFR(2), ERBB2(5), FARP2(1), FLNA(5), FLNB(3), FLNC(7), FLT1(2), FN1(5), GSK3B(1), HRAS(1), IBSP(2), IGF1R(4), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(2), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), KDR(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), MAPK10(1), MAPK8(1), MAPK9(1), MET(4), MYLK(6), MYLK2(3), MYLPF(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARVB(2), PARVG(1), PDGFC(1), PDGFRA(4), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP5K1C(1), PPP1CA(1), PTEN(1), PTK2(3), RAC2(1), RAP1B(1), RELN(6), ROCK1(2), ROCK2(1), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SRC(1), THBS1(1), THBS2(4), TLN1(7), TLN2(1), TNC(8), TNN(1), TNR(5), TNXB(6), VAV1(4), VAV3(1), VCL(1), VWF(4), ZYX(1) 32038471 320 34 317 92 87 70 56 55 48 4 0.00783 1.000 1.000 503 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(2), ACVR1C(1), AKT1(2), ARRB1(1), ARRB2(2), BDNF(1), BRAF(1), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CACNA2D1(1), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(1), CACNG3(1), CACNG5(1), CD14(2), CDC42(1), CHUK(1), CRK(1), DAXX(2), DUSP10(1), DUSP14(1), DUSP16(1), DUSP7(2), EGF(2), EGFR(2), FAS(1), FASLG(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR2(1), FGFR3(3), FGFR4(1), FLNA(5), FLNB(3), FLNC(7), HRAS(1), IKBKB(2), IL1B(1), IL1R2(2), JUND(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(1), MAX(2), MRAS(2), NF1(2), NFATC2(4), NFATC4(4), NLK(1), NR4A1(1), NTF3(2), NTRK1(2), NTRK2(2), PAK1(2), PAK2(2), PDGFRA(4), PDGFRB(2), PLA2G3(2), PLA2G6(3), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACG(2), RAC2(1), RAP1B(1), RAPGEF2(3), RASA1(1), RASA2(1), RASGRF2(1), RASGRP1(2), RASGRP2(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS1(2), SOS2(1), STK4(2), STMN1(1), TAOK1(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF1A(2), TRAF2(1) 24814869 242 32 235 75 72 43 39 39 45 4 0.0931 1.000 1.000 504 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(8), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CDK5(1), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(2), EFNA1(1), EPHA1(2), EPHA2(4), EPHA4(2), EPHA5(4), EPHA6(2), EPHA7(1), EPHA8(5), EPHB2(1), EPHB3(2), EPHB4(3), EPHB6(3), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(1), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NGEF(1), NRP1(1), NTNG1(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLXNA1(4), PLXNA2(6), PLXNA3(6), PLXNB1(4), PLXNB2(3), PLXNB3(5), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), RASA1(1), RGS3(1), RHOD(1), RND1(1), ROBO1(5), ROBO2(2), ROBO3(4), ROCK1(2), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3D(4), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(3), SEMA4G(2), SEMA5A(2), SEMA5B(3), SEMA6A(2), SEMA6C(2), SEMA7A(1), SLIT1(5), SLIT2(2), SLIT3(4), SRGAP1(2), SRGAP3(6), UNC5A(3), UNC5B(1), UNC5C(3), UNC5D(4) 16873467 210 31 204 70 63 40 33 31 43 0 0.239 1.000 1.000 505 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 CHAD(1), COL11A1(4), COL11A2(2), COL17A1(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), DES(1), DSC1(2), DSC2(3), DSC3(4), DSG1(2), DSG2(1), DSG4(2), FN1(5), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(1), GJC1(1), GJC2(2), GJC3(1), GJD4(2), IBSP(2), INA(1), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT15(3), KRT16(1), KRT17(2), KRT2(3), KRT20(1), KRT27(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(1), KRT40(1), KRT6A(2), KRT7(2), KRT73(2), KRT74(1), KRT75(1), KRT76(1), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), LMNB1(1), LMNB2(1), NES(4), PRPH(1), RELN(6), THBS1(1), THBS2(4), TNC(8), TNN(1), TNR(5), TNXB(6), VWF(4) 21554220 240 29 239 74 69 45 44 40 39 3 0.0763 1.000 1.000 506 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY7(2), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(1), ATP2A1(3), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), AVPR1B(1), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(5), CCKBR(2), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GNA11(2), GNA15(1), GNAQ(1), GNAS(6), GRIN1(5), GRIN2A(4), GRIN2C(5), GRIN2D(4), GRM1(7), GRM5(4), GRPR(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), LTB4R2(1), MYLK(6), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), PDE1B(1), PDGFRA(4), PDGFRB(2), PHKA2(2), PHKB(2), PHKG1(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PLCZ1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), PTGFR(1), RYR1(13), RYR2(8), RYR3(11), SLC25A4(1), SLC8A2(2), SLC8A3(2), SPHK1(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(1) 23761396 301 29 290 94 88 39 71 53 47 3 0.0705 1.000 1.000 507 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(2), CD44(3), CHAD(1), COL11A1(4), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), DAG1(2), FN1(5), FNDC1(5), GP6(1), GP9(2), HMMR(2), HSPG2(1), IBSP(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(2), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), RELN(6), SDC3(1), SDC4(2), SV2A(2), SV2C(1), THBS1(1), THBS2(4), TNC(8), TNN(1), TNR(5), TNXB(6), VWF(4) 19456320 197 27 196 57 53 40 39 33 29 3 0.0596 1.000 1.000 508 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ABI2(1), ACTN1(1), ACTN2(4), ACTN3(1), APC(4), APC2(1), ARAF(1), ARHGEF1(3), ARHGEF12(4), ARHGEF6(1), ARHGEF7(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(2), BRAF(1), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM5(3), CRK(1), CSK(1), CYFIP2(1), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR2(1), FGFR3(3), FGFR4(1), FN1(5), GIT1(2), GSN(4), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAM(1), ITGAV(2), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), LIMK1(1), LIMK2(1), MRAS(2), MYH10(8), MYH14(3), MYH9(1), MYLK(6), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDGFRA(4), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(3), RAC2(1), RDX(2), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), SSH1(2), SSH3(1), TIAM1(2), VAV1(4), VAV3(1), VCL(1), WASF1(1), WASF2(2), WASL(2) 24123799 207 27 200 73 51 42 40 31 41 2 0.434 1.000 1.000 509 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADRA1A(1), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1S(4), CACNB1(1), CAMK1(1), CAMK2D(1), CAMK4(2), CASQ1(1), CHRM2(3), CHRM3(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(1), GNA11(2), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(1), ITPR1(5), ITPR2(3), ITPR3(6), KCNB1(3), KCNJ5(1), MIB1(1), PLCB3(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(13), RYR2(8), RYR3(11), SLC8A3(2), YWHAH(1) 16440144 182 26 179 67 58 32 37 24 28 3 0.302 1.000 1.000 510 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(4), APC2(1), AXIN1(3), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(1), CCND3(1), CHD8(5), CREBBP(1), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CTBP2(2), CTNNB1(6), CUL1(1), DAAM1(5), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(2), EP300(4), FBXW11(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), LEF1(2), LRP5(5), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(1), MAPK9(1), MMP7(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NKD1(3), NLK(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPARD(1), PPP2R1A(1), PPP2R1B(2), PPP3CA(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PSEN1(1), RAC2(1), ROCK1(2), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), TCF7(1), TCF7L1(1), TCF7L2(1), VANGL1(1), WIF1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1) 13731428 151 25 149 47 46 32 19 29 25 0 0.0783 1.000 1.000 511 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN17(2), CLDN3(1), CLDN9(1), CSNK2A1(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), EPB41L1(2), EPB41L2(1), EPB41L3(2), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HRAS(1), IGSF5(1), JAM2(1), LLGL1(4), LLGL2(2), MAGI1(1), MAGI2(6), MAGI3(1), MLLT4(3), MPDZ(2), MRAS(2), MYH1(4), MYH10(8), MYH11(5), MYH13(1), MYH14(3), MYH15(4), MYH2(2), MYH3(1), MYH4(4), MYH6(5), MYH7(4), MYH7B(7), MYH8(3), MYH9(1), MYLPF(1), PARD3(3), PPP2R1A(1), PPP2R1B(2), PPP2R3A(3), PPP2R3B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PTEN(1), RAB13(1), SPTAN1(2), SRC(1), SYMPK(5), TJP1(4), TJP2(4), TJP3(1), YES1(1) 16825671 167 22 163 55 48 32 29 26 32 0 0.313 1.000 1.000 512 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(1), ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(2), DGKZ(3), ETS2(2), GABPA(2), GBA2(3), GNAQ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(5), ITPR2(3), ITPR3(6), MAFF(1), MIB1(1), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), PDE4D(1), PLCB3(2), PLCG1(1), PLCG2(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(13), RYR2(8), RYR3(11), SP1(1), TNXB(6), YWHAH(1) 15160464 160 22 159 58 50 24 36 24 25 1 0.312 1.000 1.000 513 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), BRAF(1), CACNA1A(6), GNA11(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GNAZ(1), GRIA1(1), GRID2(2), GRM1(7), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), HRAS(1), IGF1R(4), ITPR1(5), ITPR2(3), ITPR3(6), NOS1(5), NOS3(6), NPR1(1), NPR2(1), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP2R1A(1), PPP2R1B(2), PRKG1(1), PRKG2(1), RYR1(13) 9600748 106 20 103 30 34 11 27 18 16 0 0.204 1.000 1.000 514 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CACNA1C(6), CACNA1D(8), CACNA1F(1), CACNA1S(4), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(6), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK9(1), MMP14(4), MMP2(2), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLD2(2), PRKACG(2), PRKCD(2), SOS1(2), SOS2(1), SRC(1) 11140406 127 20 122 36 36 23 24 18 23 3 0.0908 1.000 1.000 515 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(2), BCL2L1(3), CBL(2), CBLB(1), CCND2(1), CCND3(1), CREBBP(1), CSF2RB(1), CSF3R(1), EP300(4), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), IFNK(1), IL10RA(1), IL12B(1), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL4R(1), IL6(2), IL6ST(2), IL7(1), IL7R(1), IRF9(1), JAK2(2), JAK3(3), LIF(2), LIFR(4), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(1), PIAS4(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRL(1), PRLR(2), PTPN6(4), SOCS4(1), SOS1(2), SOS2(1), SPRED2(1), SPRY4(2), STAM(3), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT5A(1), STAT6(1), TPO(3), TSLP(1), TYK2(1) 12501492 105 19 102 41 27 22 16 20 20 0 0.634 1.000 1.000 516 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(6), AKT1(2), ARAF(1), BAD(1), BRAF(1), CALML6(1), CBL(2), CBLB(1), CRK(1), EXOC7(1), FASN(9), FBP2(1), FLOT1(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS2(1), IRS4(2), LIPE(1), MAPK10(1), MAPK8(1), MAPK9(1), PCK1(2), PCK2(3), PDE3A(7), PDE3B(1), PFKL(1), PFKM(1), PFKP(1), PHKA2(2), PHKB(2), PHKG1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PKLR(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(1), PPP1R3D(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PRKCZ(1), PTPRF(6), PYGB(2), PYGM(2), SHC2(2), SHC4(2), SOCS4(1), SORBS1(1), SOS1(2), SOS2(1), TRIP10(1), TSC1(1), TSC2(4) 13815618 131 18 127 53 37 35 12 15 30 2 0.565 1.000 1.000 517 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(1), BUB1(1), CDIPT(1), CDKL1(1), CLK1(3), CSNK2A1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), MAP3K10(3), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(1), TGFBR1(2) 9882049 94 18 94 30 36 13 12 16 17 0 0.298 1.000 1.000 518 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(3), ADCY8(3), ARAF(1), BRAF(1), CACNA1C(6), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(1), EP300(4), GNAQ(1), GRIA1(1), GRIN1(5), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRM1(7), GRM5(4), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACG(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(1) 8683417 90 17 85 32 24 14 14 13 23 2 0.558 1.000 1.000 519 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(1), ACTN2(4), ACTN3(1), DES(1), DMD(5), FAM48A(1), MYBPC1(3), MYBPC3(3), MYH3(1), MYH6(5), MYH7(4), MYH8(3), MYOM1(2), NEB(11), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(2), TNNT3(1), TPM2(1), TTN(57) 11816555 114 17 113 43 30 28 29 16 9 2 0.738 1.000 1.000 520 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML6(1), CDIPT(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPP5D(1), INPPL1(3), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PLCZ1(3), PTEN(1), SYNJ2(2) 10879143 100 16 98 31 32 15 12 19 22 0 0.195 1.000 1.000 521 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 CADM1(1), CADM3(2), CD2(2), CD22(1), CD274(1), CD276(2), CD4(2), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(2), CDH2(3), CDH3(4), CDH4(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CNTN1(3), CNTN2(1), CNTNAP1(1), CNTNAP2(4), ESAM(1), F11R(1), GLG1(1), HLA-A(2), HLA-DPA1(1), HLA-DQA2(1), HLA-F(1), ICAM1(1), ICAM3(1), ICOSLG(1), ITGA8(1), ITGAM(1), ITGAV(2), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(1), NEO1(1), NFASC(1), NLGN1(4), NLGN2(2), NRCAM(1), NRXN1(2), NRXN2(2), NRXN3(2), PTPRC(2), PTPRF(6), PTPRM(5), PVRL2(1), SDC3(1), SDC4(2), SELP(3), SIGLEC1(6), VCAN(7) 12544785 119 16 113 44 32 17 27 17 26 0 0.357 1.000 1.000 522 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CALML6(1), CAMK2D(1), CREB1(1), CREB3L1(1), CREB3L2(3), CREB3L3(1), CREBBP(1), CTNNB1(6), DCT(4), DVL1(4), DVL2(2), EDN1(1), EDNRB(2), EP300(4), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GSK3B(1), HRAS(1), KIT(3), LEF1(2), MITF(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), TCF7(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1) 9548115 114 16 112 37 42 22 16 18 16 0 0.0699 1.000 1.000 523 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), CHUK(1), CREB1(1), DAXX(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP3K9(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK7(4), MAPK8(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), NFKBIA(2), PAK1(2), PAK2(2), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1) 8410886 75 16 71 31 18 16 18 5 18 0 0.859 1.000 1.000 524 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2A(1), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHX58(1), ENPP3(2), ENTPD7(1), EP400(4), ERCC2(1), ERCC3(4), G6PC2(1), GAA(1), GANC(1), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), IFIH1(3), MOV10L1(4), NUDT8(1), PGM1(1), PGM3(1), PYGB(2), PYGM(2), RAD54L(2), RUVBL2(2), SETX(3), SI(2), SKIV2L2(2), SMARCA2(2), UGDH(1), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 10685266 91 15 89 38 18 22 14 18 18 1 0.851 1.000 1.000 525 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(2), BAD(1), BCL2L1(3), CDC42(1), CREB1(1), ERBB4(6), F2RL2(1), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(3), IRS2(1), IRS4(2), MET(4), NOLC1(2), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PREX1(4), PTEN(1), PTK2(3), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1), TSC1(1), TSC2(4), YWHAE(2), YWHAH(1) 6453620 64 15 60 23 11 12 9 12 20 0 0.750 1.000 1.000 526 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BTRC(1), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), DHH(2), FBXW11(2), GLI1(4), GLI2(2), GLI3(6), GSK3B(1), HHIP(3), LRP2(2), PRKACG(2), PTCH1(2), PTCH2(4), SMO(2), STK36(1), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1), ZIC2(1) 5261115 59 14 58 22 23 11 13 7 5 0 0.445 1.000 1.000 527 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP12(1), AKAP3(2), AKAP4(1), AKAP6(2), AKAP7(2), AKAP9(3), ARHGEF1(3), GNA11(2), GNA15(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(1), GNB3(1), GNB5(1), HRAS(1), ITPR1(5), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PRKD3(3) 10110338 88 13 88 39 32 15 17 13 9 2 0.735 1.000 1.000 528 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4B(1), INPP5A(1), INPPL1(3), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PLCZ1(3), PTEN(1), SYNJ2(2) 6464435 52 13 50 20 10 9 7 13 13 0 0.672 1.000 1.000 529 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 ALG10(1), ALG10B(1), ALG12(2), ALG9(2), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(1), B4GALT5(2), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), DPAGT1(2), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS6ST1(2), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST6GAL1(1), XYLT1(2), XYLT2(4) 9675898 88 12 85 30 28 16 18 11 15 0 0.326 1.000 1.000 530 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(2), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PRKCD(2), PRKCE(1), RAC2(1), SOS1(2), SOS2(1), SYK(2), VAV1(4), VAV3(1) 6114769 60 12 59 22 15 17 8 7 12 1 0.460 1.000 1.000 531 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(2), ARHGEF11(3), BTK(1), CDC42(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(6), LIMK1(1), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PTEN(1), RACGAP1(2), ROCK1(2), ROCK2(1), WASF1(1), WASL(2) 6086562 59 12 58 20 15 11 12 9 12 0 0.476 1.000 1.000 532 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHFR(1), DHX58(1), ENTPD7(1), EP400(4), ERCC2(1), ERCC3(4), FPGS(3), GCH1(1), GGH(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54L(2), RUVBL2(2), SETX(3), SKIV2L2(2), SMARCA2(2) 5455059 67 11 64 27 14 14 7 15 16 1 0.817 1.000 1.000 533 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(4), ACTN3(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(3), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), RAC2(1), RAP1B(1), RAPGEF3(2), RAPGEF4(3), RHOH(1), ROCK1(2), ROCK2(1), SIPA1(3), VAV1(4), VAV3(1), VCL(1) 10847449 99 11 99 37 30 20 13 16 18 2 0.413 1.000 1.000 534 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(2), BRD4(4), CBL(2), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPPL1(3), IRS2(1), IRS4(2), LNPEP(2), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SORBS1(1), SOS1(2), SOS2(1), YWHAE(2), YWHAH(1) 4915492 39 11 39 17 7 11 2 8 11 0 0.818 1.000 1.000 535 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(6), ATR(5), BRCA1(3), BRCA2(6), FANCA(3), FANCC(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD17(2), TREX1(1) 3690499 33 10 32 10 4 8 5 8 8 0 0.631 1.000 1.000 536 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP7(1), CASP8(2), CFLAR(2), DAXX(2), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(4), PTPN13(3), RB1(1), SPTAN1(2) 3549059 32 10 30 10 4 2 8 7 11 0 0.779 1.000 1.000 537 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(1), CPEB1(1), EGFR(2), ERBB2(5), ERBB4(6), ETS1(1), ETS2(2), ETV7(1), FMN2(4), NOTCH1(5), NOTCH2(2), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(1), PIWIL4(1), SOS1(2), SOS2(1) 4553635 50 10 49 22 15 8 13 7 7 0 0.857 1.000 1.000 538 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CHUK(1), DAXX(2), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(1), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAPK8(1), NFKBIA(2), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 4268928 41 10 40 16 9 8 10 6 8 0 0.648 1.000 1.000 539 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(2), ASAH1(1), ATF1(1), BRAF(1), CAMP(2), CREB1(1), CREBBP(1), DAG1(2), EGR3(1), GNAQ(1), MAP1B(5), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SRC(1), TERF2IP(1) 4442584 38 10 38 19 11 7 6 5 9 0 0.870 1.000 1.000 540 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(2), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1) 3917384 35 10 35 12 9 5 6 5 10 0 0.617 1.000 1.000 541 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(2), BAD(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), SH2D2A(1), SHC2(2), SPHK1(1), SRC(1) 6004500 62 9 62 25 16 18 10 7 11 0 0.567 1.000 1.000 542 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(1), CASP1(2), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(1), MAGI2(6), RERE(4), WWP1(1), WWP2(1) 2076557 28 9 28 10 7 7 2 4 8 0 0.611 1.000 1.000 543 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), BAD(1), BCL2L1(3), CBL(2), CFLAR(2), HRAS(1), IL2RA(1), IL2RB(2), JAK3(3), PIK3CA(1), PIK3R1(1), PTPN6(4), SOS1(2), STAT5A(1), SYK(2) 2930637 28 9 26 10 6 6 4 5 7 0 0.692 1.000 1.000 544 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2F1(2), NCOA2(2), NCOA3(3), NCOR2(4), POLR2A(2), TBP(1) 2179117 18 9 16 15 3 3 3 1 7 1 0.999 1.000 1.000 545 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(1), BFAR(2), BTK(1), CAD(4), CASP10(1), CASP8(2), CASP8AP2(2), DAXX(2), DEDD(1), EGFR(2), EPHB2(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(2), TPX2(2), TRAF2(1) 6047203 51 9 51 19 10 10 13 9 9 0 0.652 1.000 1.000 546 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CEL(4), CYP27A1(1), CYP7A1(2), HADHB(2), HSD3B7(2), RDH11(2), SLC27A5(2), SOAT1(1) 2752114 30 8 27 11 9 6 6 3 6 0 0.626 1.000 1.000 547 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), HSD17B4(2), HSD3B7(2), NSD1(3), OGDH(2), OGDHL(1), PLOD1(1), PLOD2(1), RDH11(2), SETD1A(3), SETDB1(1), SHMT1(1), SHMT2(3), SUV39H2(2) 5035064 38 8 36 14 10 6 8 4 10 0 0.652 1.000 1.000 548 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), CARM1(1), DCT(4), ESCO1(4), ESCO2(1), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TPO(3), TYR(2) 5134431 49 8 49 18 16 9 11 6 7 0 0.444 1.000 1.000 549 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(3), ATM(6), ATR(5), BAI1(1), CASP8(2), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), EI24(1), FAS(1), GTSE1(2), MDM2(1), PERP(1), PTEN(1), RRM2B(1), SERPINB5(1), SERPINE1(1), SESN2(2), SESN3(2), STEAP3(1), THBS1(1), TNFRSF10B(2), TSC2(4), ZMAT3(2) 5571942 50 8 50 20 11 13 11 7 8 0 0.663 1.000 1.000 550 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(6), ACSL1(1), ACSL3(3), ACSL5(1), ADIPOR1(2), AKT1(2), CAMKK1(1), CHUK(1), CPT1B(3), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS2(1), IRS4(2), JAK2(2), JAK3(3), MAPK10(1), MAPK8(1), MAPK9(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(2), PCK2(3), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKAG3(1), PRKCQ(2), RELA(1), SLC2A1(2), STAT3(1), STK11(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(1) 7043244 67 8 67 26 17 16 10 10 13 1 0.455 1.000 1.000 551 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CBR3(2), CYP4F2(3), CYP4F3(1), EPX(4), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(3), PRDX1(1), PTGDS(2), PTGIS(2), TBXAS1(1), TPO(3) 2425130 33 8 32 14 12 3 8 2 8 0 0.774 1.000 1.000 552 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(3), ARHGAP6(3), ARHGEF1(3), ARHGEF11(3), ARHGEF5(1), ARPC2(1), BAIAP2(1), DIAPH1(3), GSN(4), LIMK1(1), MYLK(6), PIP5K1B(2), ROCK1(2), SRC(1), TLN1(7), VCL(1) 3981190 42 8 40 14 10 9 9 6 8 0 0.474 1.000 1.000 553 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CEL(4), CYP27A1(1), CYP7A1(2), HADHB(2) 2009318 21 7 18 10 6 4 3 2 6 0 0.879 1.000 1.000 554 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CLOCK(5), CRY1(1), GFRA1(2), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), PER1(2), PER2(3), TOB1(2), TUBB3(1), UCP3(1), UGP2(2) 3174872 30 7 28 14 6 5 3 9 7 0 0.874 1.000 1.000 555 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 CD4(2), CREB1(1), CTSB(2), CTSS(1), HLA-A(2), HLA-DPA1(1), HLA-DQA2(1), HLA-F(1), HSP90AA1(4), HSP90AB1(1), HSPA5(3), IFI30(1), IFNA10(1), IFNA16(1), KIR2DL1(1), KIR3DL2(1), KLRC1(1), KLRC2(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1) 3967657 32 7 32 13 3 7 7 8 7 0 0.748 1.000 1.000 556 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CSK(1), HRAS(1), ITGA1(4), MAPK8(1), PTK2(3), ROCK1(2), SOS1(2), SRC(1), TLN1(7), VCL(1), ZYX(1) 4018370 39 7 39 11 13 11 4 3 8 0 0.160 1.000 1.000 557 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CITED2(1), CPT1B(3), CREBBP(1), DUT(1), EP300(4), HSD17B4(2), LPL(2), ME1(2), NCOR1(6), NCOR2(4), NFKBIA(2), NR1H3(2), NRIP1(1), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RB1(1), RELA(1), SP1(1), STAT5A(1) 5487162 44 7 44 17 10 12 9 6 7 0 0.520 1.000 1.000 558 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(4), GTF2E2(1), GTF2H1(1), GTF2H4(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), POLR3E(3), TAF5(1), TBP(1) 3005279 24 7 22 10 9 4 4 1 6 0 0.777 1.000 1.000 559 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(1), ITPKB(3), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), SOS1(2), SOS2(1), SYK(2), VAV1(4) 4319888 33 7 33 12 11 7 3 7 4 1 0.478 1.000 1.000 560 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), ARHGEF11(3), CDC42(1), DLG4(1), LPA(3), MAP2K4(2), MAP3K1(3), MAPK8(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1), PTK2(3), RDX(2), ROCK1(2), ROCK2(1), TBXA2R(1) 4249967 35 7 35 11 5 5 9 9 7 0 0.636 1.000 1.000 561 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2A(1), ENPP3(2), GAA(1), GANAB(2), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1), PYGB(2), PYGM(2), SI(2), UGDH(1), UGT1A1(2), UGT2B15(1), UGT2B4(1) 4906708 36 7 36 13 9 10 8 3 6 0 0.469 1.000 1.000 562 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), CPT1B(3), DAO(3), DMGDH(3), GARS(4), GLDC(2), PISD(1), PLCB2(3), PLCG1(1), PLCG2(4), SARDH(1), SHMT1(1), SHMT2(3), TARS(2) 3672844 40 6 40 18 13 12 6 5 4 0 0.623 1.000 1.000 563 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), DAO(3), DMGDH(3), GARS(4), GLDC(2), HSD3B7(2), PHGDH(1), PISD(1), RDH11(2), SARDH(1), SARS2(1), SHMT1(1), SHMT2(3), TARS(2) 3734738 35 6 35 16 13 10 5 5 2 0 0.637 1.000 1.000 564 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), CBR3(2), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP4A22(1), CYP4F2(3), CYP4F3(1), DHRS4(1), GPX5(3), LTA4H(1), PLA2G3(2), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1) 3388601 31 6 30 19 7 5 10 1 8 0 0.978 1.000 1.000 565 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), BRAF(1), CAB39(1), DDIT4(1), EIF4B(2), HIF1A(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRKAA2(1), RICTOR(5), RPS6KA1(1), RPS6KA2(1), STK11(1), TSC1(1), TSC2(4), ULK1(2), ULK3(1) 4648381 37 6 37 19 11 12 4 3 7 0 0.897 1.000 1.000 566 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(3), APH1A(2), CREBBP(1), CTBP2(2), DLL4(1), DTX1(3), DTX2(3), DVL1(4), DVL2(2), EP300(4), JAG2(3), LFNG(1), MAML1(2), MAML2(1), NCOR2(4), NOTCH1(5), NOTCH2(2), NOTCH3(7), NOTCH4(4), NUMBL(1), PSEN1(1), PSEN2(1), RBPJ(2), SNW1(1) 6022689 60 6 60 28 19 18 12 6 5 0 0.631 1.000 1.000 567 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ARRB2(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(1), CLCA4(1), CNGA3(1), CNGA4(1), CNGB1(6), GUCA1A(1), GUCA1C(1), PRKACG(2), PRKG1(1), PRKG2(1) 2640029 26 6 25 10 8 3 9 3 3 0 0.691 1.000 1.000 568 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(4), CTPS2(1), DPYD(3), DPYS(4), DUT(1), NT5E(1), NT5M(1), POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1), RRM1(1), TYMS(1), UMPS(2), UPB1(2) 4995602 46 6 46 15 13 12 9 6 6 0 0.237 1.000 1.000 569 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(7), B3GALT4(1), DGKI(2), FAU(1), IL6ST(2), RPL10(2), RPL18A(1), RPL24(1), RPL35(1), RPL3L(2), RPL4(2), RPL7A(1), RPS11(2), RPS27A(1), RPS28(1), RPS6KA1(1), RPS6KA2(1), RPSA(2), SLC36A2(1), TSPAN9(1) 4548187 33 6 32 21 10 5 8 4 6 0 0.992 1.000 1.000 570 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), G6PC2(1), GAPDHS(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 5014183 47 5 47 14 19 11 7 4 6 0 0.131 1.000 1.000 571 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(1), CARM1(1), CYP11B1(2), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), STS(2), SULT2A1(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 4314388 27 5 27 10 3 10 8 2 4 0 0.597 1.000 1.000 572 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1) 3041857 21 5 21 12 7 5 4 0 5 0 0.811 1.000 1.000 573 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL3(1), FBXW11(2), FBXW7(3), ITCH(2), SKP1(1), TCEB1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(1) 3475611 28 5 28 11 7 8 6 3 4 0 0.730 1.000 1.000 574 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), CRK(1), DOCK1(2), HRAS(1), ITGA1(4), MAP4K1(2), MAPK8(1), MET(4), PAK1(2), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), RAP1B(1), RASA1(1), SOS1(2), SRC(1), STAT3(1) 3865320 31 5 30 13 5 12 3 5 6 0 0.694 1.000 1.000 575 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM5(3), DRD1(2), DRD2(1), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1) 2256157 28 5 28 12 9 5 8 5 1 0 0.605 1.000 1.000 576 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), DCT(4), GOT1(2), HGD(2), HPD(2), TPO(3), TYR(2) 2743392 34 5 34 13 15 5 6 4 4 0 0.372 1.000 1.000 577 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(4), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1) 2419676 27 5 27 11 7 6 5 3 6 0 0.667 1.000 1.000 578 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4) 595386 10 4 8 11 3 3 1 0 3 0 0.985 1.000 1.000 579 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1) 1589099 19 4 18 10 3 5 2 4 5 0 0.829 1.000 1.000 580 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4) 595386 10 4 8 11 3 3 1 0 3 0 0.985 1.000 1.000 581 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), DNMT3A(4), DNMT3B(2), MTFMT(2), MTR(1) 1792797 12 4 11 10 3 1 3 2 3 0 0.988 1.000 1.000 582 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3) 1958548 23 4 22 12 5 6 4 3 5 0 0.793 1.000 1.000 583 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1) 2483054 23 4 23 12 7 3 6 3 4 0 0.850 1.000 1.000 584 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), SHMT1(1), SHMT2(3) 3209730 22 4 22 12 6 5 7 0 4 0 0.876 1.000 1.000 585 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(2), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS2(1), JAK3(3), MAP4K1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SOS1(2), SOS2(1), STAT6(1) 3005079 20 4 20 12 5 7 1 4 3 0 0.901 1.000 1.000 586 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 4203400 40 3 40 13 16 9 6 4 5 0 0.221 1.000 1.000 587 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 4203400 40 3 40 13 16 9 6 4 5 0 0.221 1.000 1.000 588 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), GCDH(2), HADHA(1), HEMK1(1), HSD17B4(2), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL6(1), OGDH(2), OGDHL(1), PRMT3(1), PRMT6(1), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2) 5225886 45 3 45 10 14 6 13 5 7 0 0.107 1.000 1.000 589 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), GCDH(2), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2) 4738587 44 3 44 12 14 6 12 6 6 0 0.192 1.000 1.000 590 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(1) 453739 4 2 4 4 3 1 0 0 0 0 0.949 1.000 1.000 591 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(3), MAP2(2), PPP1CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1) 1557445 10 2 10 6 4 3 1 2 0 0 0.889 1.000 1.000 592 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), HAL(1), PRPS1(1) 2105690 12 2 12 6 6 4 1 1 0 0 0.594 1.000 1.000 593 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), HRAS(1), IL6(2), IL6ST(2), JAK2(2), JAK3(3), SOS1(2), STAT3(1) 2086017 14 2 14 13 2 3 4 2 3 0 0.996 1.000 1.000 594 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(4), DNMT3B(2), MTR(1) 1501426 9 2 9 9 3 1 3 2 0 0 0.984 1.000 1.000 595 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1) 1179836 8 2 8 5 4 2 1 1 0 0 0.787 1.000 1.000 596 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH3A1(1) 690280 2 1 2 2 2 0 0 0 0 0 0.904 1.000 1.000 597 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH3A1(1) 690280 2 1 2 2 2 0 0 0 0 0 0.904 1.000 1.000 598 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NQO2(2), SQLE(1), VKORC1(2) 968127 11 1 11 6 2 3 5 1 0 0 0.802 1.000 1.000 599 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1) 1147439 8 1 8 6 2 2 4 0 0 0 0.928 1.000 1.000 600 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), CPT1B(3), CPT1C(2), CPT2(1), CYP4A22(1), GCDH(2), HADHA(1), HADHB(2), HSD17B4(2) 4209314 38 1 38 8 12 11 5 4 6 0 0.0446 1.000 1.000 601 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), FDFT1(2), GGCX(1), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1), VKORC1(2) 1678567 11 1 11 7 3 2 5 1 0 0 0.891 1.000 1.000 602 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(1), KARS(1) 403590 2 1 2 3 0 0 1 1 0 0 0.989 1.000 1.000 603 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(1) 393021 2 1 2 2 1 1 0 0 0 0 0.914 1.000 1.000 604 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1), PNPO(1) 417727 2 1 2 2 0 0 2 0 0 0 0.946 1.000 1.000 605 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), SQLE(1) 367777 3 1 3 3 1 1 1 0 0 0 0.922 1.000 1.000 606 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 579743 2 1 2 2 1 1 0 0 0 0 0.886 1.000 1.000 607 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(1), KARS(1) 593879 4 1 4 3 0 0 3 1 0 0 0.964 1.000 1.000 608 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1) 333282 1 1 1 2 0 0 0 1 0 0 0.993 1.000 1.000 609 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(1), RB1(1) 739343 3 1 3 4 0 1 1 1 0 0 0.989 1.000 1.000 610 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(1), CDC34(1), CUL1(1), RB1(1) 740661 6 1 6 4 1 2 2 1 0 0 0.911 1.000 1.000 611 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(1), PTGDR(2), PTGFR(1), TBXA2R(1) 999644 5 1 5 5 1 1 3 0 0 0 0.938 1.000 1.000 612 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 275947 3 1 3 3 1 1 1 0 0 0 0.921 1.000 1.000 613 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 6 THBS1(1) 528867 1 1 1 2 1 0 0 0 0 0 0.950 1.000 1.000 614 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 198111 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 43203 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 97779 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000