Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	15.0	709.0	46.0	-0.98	0.029	1000.0	-1000.0	-0.135	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	315.0	34.0	-0.369	0.013	1000.0	-1000.0	-0.103	-1000.0
IL23-mediated signaling events	9.0	555.0	60.0	-0.681	0.013	1000.0	-1000.0	-0.22	-1000.0
IL4-mediated signaling events	8.0	797.0	91.0	-0.835	0.776	1000.0	-1000.0	-0.208	-1000.0
HIF-1-alpha transcription factor network	7.0	598.0	76.0	-0.71	0.022	1000.0	-1000.0	-0.26	-1000.0
TCGA08_retinoblastoma	7.0	56.0	8.0	-0.211	0.07	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by the Hedgehog family	6.0	337.0	52.0	-0.215	0.161	1000.0	-1000.0	-0.118	-1000.0
p75(NTR)-mediated signaling	6.0	768.0	125.0	-0.397	0.013	1000.0	-1000.0	-0.164	-1000.0
IL6-mediated signaling events	6.0	478.0	75.0	-0.613	0.047	1000.0	-1000.0	-0.143	-1000.0
BCR signaling pathway	6.0	661.0	99.0	-0.501	0.014	1000.0	-1000.0	-0.145	-1000.0
Ephrin A  reverse signaling	5.0	35.0	7.0	-0.067	0.0	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	5.0	381.0	76.0	-0.476	0.09	1000.0	-1000.0	-0.126	-1000.0
Glypican 1 network	5.0	255.0	48.0	-0.484	0.037	1000.0	-1000.0	-0.069	-1000.0
amb2 Integrin signaling	5.0	426.0	82.0	-0.335	0.013	1000.0	-1000.0	-0.14	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	472.0	93.0	-0.226	0.108	1000.0	-1000.0	-0.136	-1000.0
Wnt signaling	5.0	36.0	7.0	-0.245	0.013	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	5.0	118.0	21.0	-0.429	0.013	1000.0	-1000.0	-0.123	-1000.0
Visual signal transduction: Rods	5.0	287.0	52.0	-0.407	0.013	1000.0	-1000.0	-0.139	-1000.0
IL12-mediated signaling events	4.0	394.0	87.0	-0.35	0.057	1000.0	-1000.0	-0.184	-1000.0
Visual signal transduction: Cones	4.0	157.0	38.0	-0.207	0.013	1000.0	-1000.0	-0.109	-1000.0
Glucocorticoid receptor regulatory network	4.0	569.0	114.0	-0.695	0.327	1000.0	-1000.0	-0.122	-1000.0
Reelin signaling pathway	4.0	270.0	56.0	-0.296	0.013	1000.0	-1000.0	-0.142	-1000.0
TCGA08_p53	4.0	30.0	7.0	-0.162	0.07	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	193.0	44.0	-0.237	0.013	1000.0	-1000.0	-0.08	-1000.0
Effects of Botulinum toxin	4.0	112.0	26.0	-0.231	0.019	1000.0	-1000.0	-0.099	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	129.0	31.0	-0.394	0.014	1000.0	-1000.0	-0.136	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	318.0	68.0	-0.476	0.13	1000.0	-1000.0	-0.195	-1000.0
IGF1 pathway	4.0	237.0	57.0	-0.291	0.066	1000.0	-1000.0	-0.152	-1000.0
Insulin Pathway	4.0	305.0	74.0	-0.471	0.029	1000.0	-1000.0	-0.153	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.047	-1000.0	1000.0	-1000.0	-0.027	-1000.0
Syndecan-1-mediated signaling events	3.0	103.0	34.0	-0.27	0.013	1000.0	-1000.0	-0.113	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	162.0	54.0	-0.286	0.025	1000.0	-1000.0	-0.162	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	67.0	17.0	-0.154	0.013	1000.0	-1000.0	-0.1	-1000.0
Arf6 signaling events	3.0	209.0	62.0	-0.429	0.014	1000.0	-1000.0	-0.104	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	180.0	52.0	-0.365	0.055	1000.0	-1000.0	-0.103	-1000.0
Glypican 2 network	3.0	12.0	4.0	-0.045	-0.044	1000.0	-1000.0	-0.058	-1000.0
Syndecan-4-mediated signaling events	3.0	246.0	67.0	-0.284	0.053	1000.0	-1000.0	-0.142	-1000.0
Plasma membrane estrogen receptor signaling	3.0	286.0	86.0	-0.292	0.066	1000.0	-1000.0	-0.135	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	446.0	120.0	-0.46	0.212	1000.0	-1000.0	-0.146	-1000.0
ErbB4 signaling events	2.0	180.0	69.0	-0.318	0.165	1000.0	-1000.0	-0.14	-1000.0
Noncanonical Wnt signaling pathway	2.0	73.0	26.0	-0.245	0.013	1000.0	-1000.0	-0.129	-1000.0
Thromboxane A2 receptor signaling	2.0	272.0	105.0	-0.429	0.032	1000.0	-1000.0	-0.124	-1000.0
Syndecan-2-mediated signaling events	2.0	143.0	69.0	-0.208	0.045	1000.0	-1000.0	-0.102	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	-0.047	-0.003	1000.0	-1000.0	-0.06	-1000.0
BMP receptor signaling	2.0	217.0	81.0	-0.328	0.058	1000.0	-1000.0	-0.147	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	286.0	97.0	-0.207	0.035	1000.0	-1000.0	-0.142	-1000.0
mTOR signaling pathway	2.0	134.0	53.0	-0.476	0.033	1000.0	-1000.0	-0.099	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	96.0	37.0	-0.208	0.013	1000.0	-1000.0	-0.137	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	232.0	82.0	-0.215	0.013	1000.0	-1000.0	-0.146	-1000.0
HIF-2-alpha transcription factor network	2.0	108.0	43.0	-0.117	0.031	1000.0	-1000.0	-0.134	-1000.0
Endothelins	2.0	265.0	96.0	-0.267	0.075	1000.0	-1000.0	-0.131	-1000.0
S1P1 pathway	2.0	73.0	36.0	-0.187	0.013	1000.0	-1000.0	-0.094	-1000.0
FAS signaling pathway (CD95)	2.0	115.0	47.0	-0.346	0.056	1000.0	-1000.0	-0.086	-1000.0
Syndecan-3-mediated signaling events	2.0	87.0	35.0	-0.151	0.013	1000.0	-1000.0	-0.107	-1000.0
Integrins in angiogenesis	2.0	202.0	84.0	-0.292	0.027	1000.0	-1000.0	-0.149	-1000.0
Nongenotropic Androgen signaling	2.0	113.0	52.0	-0.094	0.013	1000.0	-1000.0	-0.104	-1000.0
IL27-mediated signaling events	2.0	151.0	51.0	-0.332	0.04	1000.0	-1000.0	-0.151	-1000.0
LPA receptor mediated events	2.0	276.0	102.0	-0.208	0.035	1000.0	-1000.0	-0.144	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	238.0	88.0	-0.157	0.053	1000.0	-1000.0	-0.151	-1000.0
Rapid glucocorticoid signaling	2.0	44.0	20.0	-0.265	0.013	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	157.0	78.0	-0.202	0.058	1000.0	-1000.0	-0.116	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.097	0.014	1000.0	-1000.0	-0.071	-1000.0
LPA4-mediated signaling events	1.0	13.0	12.0	-0.023	0.022	1000.0	-1000.0	-0.044	-1000.0
Caspase cascade in apoptosis	1.0	98.0	74.0	-0.109	0.025	1000.0	-1000.0	-0.089	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	174.0	136.0	-0.202	0.09	1000.0	-1000.0	-0.127	-1000.0
Coregulation of Androgen receptor activity	1.0	134.0	76.0	-0.205	0.033	1000.0	-1000.0	-0.075	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	34.0	28.0	-0.094	0.026	1000.0	-1000.0	-0.093	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	100.0	85.0	-0.093	0.027	1000.0	-1000.0	-0.118	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	112.0	61.0	-0.323	0.04	1000.0	-1000.0	-0.118	-1000.0
EPO signaling pathway	1.0	77.0	55.0	-0.2	0.015	1000.0	-1000.0	-0.165	-1000.0
Ceramide signaling pathway	1.0	134.0	76.0	-0.429	0.12	1000.0	-1000.0	-0.108	-1000.0
IL1-mediated signaling events	1.0	75.0	62.0	-0.143	0.066	1000.0	-1000.0	-0.156	-1000.0
S1P5 pathway	1.0	28.0	17.0	-0.094	0.061	1000.0	-1000.0	-0.094	-1000.0
Ephrin B reverse signaling	1.0	52.0	48.0	-0.108	0.03	1000.0	-1000.0	-0.122	-1000.0
Retinoic acid receptors-mediated signaling	1.0	95.0	58.0	-0.266	0.023	1000.0	-1000.0	-0.123	-1000.0
Canonical Wnt signaling pathway	1.0	101.0	51.0	-0.323	0.083	1000.0	-1000.0	-0.092	-1000.0
Regulation of p38-alpha and p38-beta	1.0	70.0	54.0	-0.427	0.013	1000.0	-1000.0	-0.099	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	75.0	74.0	-0.429	0.081	1000.0	-1000.0	-0.148	-1000.0
Class I PI3K signaling events	1.0	76.0	73.0	-0.427	0.04	1000.0	-1000.0	-0.122	-1000.0
Regulation of Telomerase	1.0	173.0	102.0	-0.43	0.053	1000.0	-1000.0	-0.153	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	49.0	33.0	-0.209	0.036	1000.0	-1000.0	-0.108	-1000.0
FOXM1 transcription factor network	1.0	65.0	51.0	-0.22	0.149	1000.0	-1000.0	-0.232	-1000.0
S1P4 pathway	1.0	45.0	25.0	-0.094	0.013	1000.0	-1000.0	-0.09	-1000.0
p38 MAPK signaling pathway	1.0	69.0	44.0	-0.279	0.019	1000.0	-1000.0	-0.106	-1000.0
Regulation of Androgen receptor activity	1.0	133.0	70.0	-0.345	0.076	1000.0	-1000.0	-0.103	-1000.0
ErbB2/ErbB3 signaling events	0.0	59.0	65.0	-0.16	0.031	1000.0	-1000.0	-0.117	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.052	1000.0	-1000.0	-0.119	-1000.0
Canonical NF-kappaB pathway	0.0	13.0	39.0	-0.074	0.092	1000.0	-1000.0	-0.14	-1000.0
Signaling events mediated by HDAC Class II	0.0	42.0	75.0	-0.096	0.039	1000.0	-1000.0	-0.104	-1000.0
BARD1 signaling events	0.0	36.0	57.0	-0.025	0.067	1000.0	-1000.0	-0.106	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.001	0.014	1000.0	-1000.0	-0.034	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.016	0.035	1000.0	-1000.0	-0.094	-1000.0
Osteopontin-mediated events	0.0	25.0	38.0	-0.077	0.016	1000.0	-1000.0	-0.172	-1000.0
Cellular roles of Anthrax toxin	0.0	32.0	39.0	-0.074	0.021	1000.0	-1000.0	-0.062	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	26.0	65.0	-0.093	0.082	1000.0	-1000.0	-0.104	-1000.0
Aurora A signaling	0.0	21.0	60.0	-0.078	0.033	1000.0	-1000.0	-0.1	-1000.0
Arf6 downstream pathway	0.0	16.0	43.0	-0.015	0.027	1000.0	-1000.0	-0.067	-1000.0
Aurora C signaling	0.0	0.0	7.0	0.0	0.013	1000.0	-1000.0	-0.069	-1000.0
PLK1 signaling events	0.0	13.0	85.0	-0.012	0.037	1000.0	-1000.0	-0.089	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.035	0.043	1000.0	-1000.0	-0.099	-1000.0
PDGFR-alpha signaling pathway	0.0	12.0	44.0	-0.055	0.034	1000.0	-1000.0	-0.095	-1000.0
IFN-gamma pathway	0.0	61.0	68.0	-0.279	0.039	1000.0	-1000.0	-0.156	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	17.0	68.0	-0.044	0.06	1000.0	-1000.0	-0.097	-1000.0
Nectin adhesion pathway	0.0	13.0	63.0	-0.029	0.067	1000.0	-1000.0	-0.114	-1000.0
Signaling events mediated by HDAC Class III	0.0	28.0	40.0	-0.083	0.025	1000.0	-1000.0	-0.064	-1000.0
TRAIL signaling pathway	0.0	18.0	48.0	-0.032	0.06	1000.0	-1000.0	-0.112	-1000.0
ceramide signaling pathway	0.0	16.0	49.0	-0.073	0.042	1000.0	-1000.0	-0.084	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	60.0	83.0	-0.211	0.066	1000.0	-1000.0	-0.123	-1000.0
Signaling events mediated by HDAC Class I	0.0	61.0	104.0	-0.15	0.053	1000.0	-1000.0	-0.107	-1000.0
FoxO family signaling	0.0	51.0	64.0	-0.34	0.128	1000.0	-1000.0	-0.119	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	10.0	15.0	-0.001	0.024	1000.0	-1000.0	-0.056	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.047	0.027	1000.0	-1000.0	-0.116	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.035	0.049	1000.0	-1000.0	-0.117	-1000.0
IL2 signaling events mediated by PI3K	0.0	42.0	58.0	-0.093	0.055	1000.0	-1000.0	-0.134	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	38.0	45.0	-0.169	0.052	1000.0	-1000.0	-0.143	-1000.0
EPHB forward signaling	0.0	71.0	85.0	-0.14	0.05	1000.0	-1000.0	-0.151	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	13.0	125.0	-0.026	0.096	1000.0	-1000.0	-0.167	-1000.0
TCGA08_rtk_signaling	0.0	7.0	26.0	-0.031	0.053	1000.0	-1000.0	-0.033	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	12.0	76.0	-0.018	0.067	1000.0	-1000.0	-0.13	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.008	0.032	1000.0	-1000.0	-0.093	-1000.0
IL2 signaling events mediated by STAT5	0.0	14.0	22.0	-0.086	0.047	1000.0	-1000.0	-0.093	-1000.0
Arf6 trafficking events	0.0	59.0	71.0	-0.244	0.048	1000.0	-1000.0	-0.129	-1000.0
VEGFR1 specific signals	0.0	5.0	56.0	-0.017	0.074	1000.0	-1000.0	-0.126	-1000.0
S1P3 pathway	0.0	36.0	42.0	-0.092	0.028	1000.0	-1000.0	-0.098	-1000.0
PDGFR-beta signaling pathway	0.0	39.0	97.0	-0.246	0.057	1000.0	-1000.0	-0.144	-1000.0
Signaling events mediated by PRL	0.0	24.0	34.0	-0.074	0.025	1000.0	-1000.0	-0.084	-1000.0
E-cadherin signaling in keratinocytes	0.0	21.0	43.0	-0.022	0.047	1000.0	-1000.0	-0.112	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.013	1000.0	-1000.0	-0.069	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.029	0.024	1000.0	-1000.0	-0.07	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.011	0.013	1000.0	-1000.0	-0.11	-1000.0
Aurora B signaling	0.0	25.0	67.0	-0.146	0.04	1000.0	-1000.0	-0.108	-1000.0
Total	263	18324	7203	-29.0758969393	-993.299412898	131000	-131000	-15.0881101117	-131000