rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(1), CAT(2), GHR(2), HRAS(2), IGF1R(2), PIK3R1(2), SHC1(2), SOD2(1), SOD3(1) 4184639 15 15 15 1 5 5 3 0 2 0 0.0703 0.00444 1.000 2 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(3), SP1(1), SP3(2) 2482692 9 8 9 1 1 3 1 1 2 1 0.219 0.00634 1.000 3 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4) 1113489 4 4 4 1 1 1 1 1 0 0 0.667 0.0165 1.000 4 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(3), DHFR(1), FTCD(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), SHMT1(3), SHMT2(1) 7105204 18 17 18 2 4 6 0 2 6 0 0.0976 0.0216 1.000 5 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(3), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), SHMT1(3), SHMT2(1) 6699692 17 16 17 2 4 6 0 2 5 0 0.120 0.0295 1.000 6 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(1), HRAS(2), KLK2(1), NTRK1(3), PIK3R1(2), PLCG1(1), PRKCA(1), SHC1(2), SOS1(1) 5013584 14 13 14 1 6 5 1 1 1 0 0.0732 0.0387 1.000 7 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(1), HRAS(2), MAPK1(1), MEF2C(2), MEF2D(2), NTRK1(3), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(2) 6302690 17 17 17 1 10 5 2 0 0 0 0.0190 0.0418 1.000 8 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 271587 2 2 2 1 1 1 0 0 0 0 0.795 0.0476 1.000 9 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(3) 1997020 6 6 6 1 2 3 0 1 0 0 0.366 0.0554 1.000 10 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 12 BLVRB(1), HMOX1(1), IL10RA(3), IL6(1), JAK1(2), STAT1(1), STAT5A(1), TNF(1) 3979294 11 10 11 1 4 3 3 0 1 0 0.117 0.0598 1.000 11 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(1), LPO(1), MTHFR(2), SHMT1(3), SHMT2(1), TPO(1) 4366846 11 11 11 1 4 3 1 0 3 0 0.114 0.0906 1.000 12 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(2), ITPKB(2) 2286645 6 6 6 0 4 2 0 0 0 0 0.0913 0.110 1.000 13 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(1), ADORA3(1), P2RY1(1), P2RY6(1) 2238333 6 6 6 0 4 1 0 1 0 0 0.107 0.113 1.000 14 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(3), HADHB(1) 3133727 8 7 8 1 1 4 3 0 0 0 0.276 0.122 1.000 15 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), GNGT1(1), HTR2C(2), PLCB1(2), TUB(1) 2682191 7 6 7 1 3 3 1 0 0 0 0.282 0.132 1.000 16 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3), JUND(1) 1415779 4 4 4 1 1 1 1 1 0 0 0.570 0.133 1.000 17 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CFL1(1), MDM2(1), PRB1(1) 2886976 11 9 11 2 3 1 0 0 7 0 0.668 0.136 1.000 18 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(2), NEK1(2) 2599714 6 6 6 0 5 0 0 0 1 0 0.144 0.138 1.000 19 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT2(1), CDKN1A(2), HRAS(2), NTRK1(3), PIK3CD(1), SHC1(2), SOS1(1) 5254127 13 13 13 2 6 5 1 0 1 0 0.137 0.139 1.000 20 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), LEPR(1), PRKAA2(3), PRKAG1(2), PRKAG2(1) 5418220 11 10 11 1 4 3 3 1 0 0 0.136 0.148 1.000 21 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(3), ERBB3(4), NRG1(1) 3855437 8 8 8 1 1 4 0 0 3 0 0.245 0.159 1.000 22 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS2(1), SULT1E1(2) 2279097 6 6 6 0 3 2 0 0 1 0 0.184 0.164 1.000 23 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(1), CSK(1), PRKCA(1), PTPRA(3) 3454703 7 7 7 1 3 2 0 2 0 0 0.351 0.172 1.000 24 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGDH(1), UGP2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1) 10192259 18 17 18 2 2 6 2 4 4 0 0.134 0.175 1.000 25 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(1), CDK4(1), CDKN1A(2), CDKN1B(4), HRAS(2), MAPK1(1), NFKB1(2), PIK3R1(2), RAC1(1), RAF1(1), RB1(3), RELA(1) 6773852 21 15 21 3 7 5 4 0 4 1 0.152 0.185 1.000 26 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 833516 2 2 2 0 0 0 0 0 2 0 0.517 0.192 1.000 27 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1) 3847569 7 7 7 1 2 2 1 1 1 0 0.332 0.193 1.000 28 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 HLA-DRA(1), IL4(1), IL5RA(1), IL6(1) 1998188 4 4 4 0 2 2 0 0 0 0 0.211 0.195 1.000 29 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(1), XYLT1(4) 2499819 8 8 8 0 4 2 0 0 2 0 0.0545 0.197 1.000 30 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(1), XYLT1(4) 2499819 8 8 8 0 4 2 0 0 2 0 0.0545 0.197 1.000 31 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(3) 1817230 4 4 4 0 0 2 1 1 0 0 0.339 0.207 1.000 32 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 190250 1 1 1 0 0 0 0 0 1 0 0.661 0.217 1.000 33 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(3), ITGAM(2), ITGB2(2), SELE(1) 3906322 8 7 8 1 4 2 1 1 0 0 0.208 0.229 1.000 34 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(1), BCAR1(1), CDKN1B(4), MAPK1(1), PDPK1(1), PIK3R1(2), PTK2(2), SHC1(2), SOS1(1) 6126754 15 13 15 2 6 4 0 0 5 0 0.271 0.244 1.000 35 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSB(1), ARSE(2), CYP11B2(1), HSD11B1(1), HSD17B3(1), STS(2), SULT1E1(2), UGT1A1(3), UGT2B15(2) 10232509 17 15 17 1 4 5 2 2 4 0 0.0289 0.244 1.000 36 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(1), BAD(1), HRAS(2), NFKB1(2), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(1), RELA(1) 6331909 13 12 13 1 3 6 3 0 1 0 0.0699 0.261 1.000 37 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1) 3814707 8 8 8 2 2 1 3 1 1 0 0.536 0.265 1.000 38 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(1), BAD(1), HRAS(2), IGF1R(2), IRS1(2), MAPK1(1), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1) 6289011 15 14 15 3 6 4 3 1 1 0 0.312 0.267 1.000 39 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(2), EXTL1(3), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST2(1), HS6ST1(1), NDST1(3), NDST2(1), NDST4(4) 7781966 20 18 20 3 5 7 5 3 0 0 0.103 0.272 1.000 40 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1459355 3 3 3 0 1 1 0 1 0 0 0.405 0.279 1.000 41 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(3), MEF2C(2), MEF2D(2) 2898700 9 8 8 2 6 1 1 1 0 0 0.316 0.284 1.000 42 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(1), PIK3R1(2), PLCB1(2), PLCG1(1), PRKCA(1), VAV1(2) 3984569 9 8 9 0 4 3 0 2 0 0 0.0658 0.284 1.000 43 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(1), LPO(1), SHMT1(3), SHMT2(1), TPO(1) 4442575 9 9 9 1 3 2 1 0 3 0 0.196 0.285 1.000 44 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE2(1), CDK4(1), CDKN1B(4), CDKN2A(1), PRB1(1) 3401725 9 9 9 2 1 2 1 0 5 0 0.699 0.290 1.000 45 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(1), ARHGEF1(3), F2(1), F2RL3(1), GNA12(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3R1(2), PLCB1(2), PRKCA(1), ROCK1(4) 8875816 21 16 21 3 6 7 3 2 3 0 0.120 0.290 1.000 46 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2C(2), MEF2D(2), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1) 7606815 17 15 17 2 9 3 1 2 2 0 0.0811 0.290 1.000 47 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(1), SRPR(1) 2820817 5 5 5 0 1 1 0 1 2 0 0.244 0.300 1.000 48 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPT(2), ENPP1(2), ENPP3(2), RFK(1) 3637517 8 8 8 2 2 2 1 1 2 0 0.506 0.307 1.000 49 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SP1(1), SP3(2), SYT1(1) 7857473 14 12 14 1 5 2 1 4 2 0 0.0757 0.316 1.000 50 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(1), CDKN1A(2), CPB2(1), HIC1(1), HSPA1A(1), MDM2(1), NQO1(1) 5158829 12 9 12 1 7 2 1 0 2 0 0.121 0.317 1.000 51 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(3), SHMT2(1) 1565789 4 4 4 0 2 0 0 0 2 0 0.205 0.317 1.000 52 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1) 4399671 7 7 7 1 2 2 1 1 1 0 0.318 0.321 1.000 53 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ACAT1(1) 2026645 3 3 2 1 2 1 0 0 0 0 0.676 0.326 1.000 54 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(2), PRKCA(1), RELA(1) 3094487 6 6 6 0 1 4 0 1 0 0 0.169 0.336 1.000 55 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(3), CDKN2A(1), MDM2(1), PIK3R1(2), POLR1A(4), POLR1B(1), POLR1C(2), RAC1(1), RB1(3) 6495208 18 11 18 1 4 5 3 2 3 1 0.0316 0.337 1.000 56 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(1), EIF4A1(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MAPK1(1), PDPK1(1), PIK3R1(2), PRKCA(1) 9437959 16 15 16 1 4 5 0 4 3 0 0.0755 0.346 1.000 57 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRA(1), IL4(1) 1487139 2 2 2 0 2 0 0 0 0 0 0.463 0.349 1.000 58 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), LARS(1), LARS2(1), PDHA2(1) 3747460 5 5 5 0 1 1 2 0 1 0 0.204 0.350 1.000 59 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1) 3482893 5 5 5 1 1 1 0 1 2 0 0.497 0.353 1.000 60 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1) 3482893 5 5 5 1 1 1 0 1 2 0 0.497 0.353 1.000 61 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX5AP(1), DPEP1(2), PLA2G2A(1), PTGS1(1), PTGS2(3) 5679677 10 10 10 1 3 5 0 1 1 0 0.107 0.359 1.000 62 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ7(1) 1507764 2 2 2 1 0 1 1 0 0 0 0.854 0.362 1.000 63 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), BAD(1), BTK(1), EEA1(2), GSK3A(1), GSK3B(1), PDPK1(1), PFKM(1), PFKP(1), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(1) 9453402 15 15 15 1 4 7 2 1 1 0 0.0363 0.369 1.000 64 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 CDK4(1), CDKN1B(4), CEBPB(1), EGR1(1), FSHR(1), GJA4(1), LHCGR(1), MLH1(1), MSH5(1), NCOR1(5), NRIP1(1), PGR(2), PTGER2(1), VDR(1), ZP2(1) 10804173 23 19 23 4 5 1 4 0 13 0 0.354 0.371 1.000 65 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 570494 1 1 1 0 0 1 0 0 0 0 0.803 0.372 1.000 66 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(1), BAD(1), GHR(2), NFKB1(2), PDPK1(1), PIK3R1(2), RELA(1) 4476742 10 9 10 0 2 8 0 0 0 0 0.0427 0.384 1.000 67 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(5), EP300(4), ESR1(1), MAPK1(1), PELP1(1) 5556797 12 11 12 2 6 2 1 1 2 0 0.214 0.388 1.000 68 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1), KERA(1) 1347283 2 2 2 1 1 1 0 0 0 0 0.790 0.388 1.000 69 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGFR(3), TF(2) 4802991 7 7 7 0 1 6 0 0 0 0 0.125 0.394 1.000 70 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL16(2), IL4(1), IL6(1), IL9(1), LTA(1), TNF(1) 3713338 7 6 7 1 2 3 2 0 0 0 0.298 0.403 1.000 71 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), FCGR2B(1), HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(3) 5683619 11 10 11 2 6 2 1 2 0 0 0.263 0.405 1.000 72 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR3(1), PDGFRA(3), PIK3R1(2), RAC1(1) 4189809 7 7 7 1 4 0 1 1 1 0 0.398 0.417 1.000 73 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 NFS1(2), THTPA(2) 2402927 4 4 4 1 2 0 1 0 1 0 0.532 0.419 1.000 74 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), NRG2(1), NRG3(2), PRKCA(1), PSEN1(1) 3382302 6 5 6 1 2 1 0 1 2 0 0.471 0.428 1.000 75 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(2), RELA(1), TNFRSF13B(3), TRAF2(2), TRAF5(1) 5461896 9 8 9 1 1 7 0 0 1 0 0.197 0.435 1.000 76 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCS1(2), HMGCS2(1) 2691387 4 4 4 1 1 2 0 0 1 0 0.619 0.435 1.000 77 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(3), CREBBP(5), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(1), TGFBR1(2) 9628905 20 16 20 3 7 3 3 2 5 0 0.186 0.435 1.000 78 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(1) 888619 1 1 1 0 1 0 0 0 0 0 0.679 0.436 1.000 79 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(1), EGFR(3), IGF1R(2), POLR2A(2), PRKCA(1), RB1(3), TEP1(4), TNKS(3) 10282209 19 17 19 2 3 9 3 2 1 1 0.0664 0.436 1.000 80 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(4), RB1(3) 3208457 7 6 7 2 0 1 1 0 4 1 0.870 0.445 1.000 81 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(3), CHST11(1), PAPSS2(1), SULT1E1(2) 3463090 7 7 7 0 4 2 0 0 1 0 0.101 0.456 1.000 82 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), GOT1(1), PAH(1) 3104839 4 4 4 1 3 0 0 0 1 0 0.548 0.461 1.000 83 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(1), CPOX(1), EPRS(2), HMBS(3), HMOX1(1), HMOX2(1), UGT1A1(3), UGT2B15(2) 10272527 15 14 15 1 8 2 2 2 1 0 0.0413 0.463 1.000 84 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 SP1(1), SP3(2) 2340995 3 3 3 0 0 1 0 1 1 0 0.474 0.464 1.000 85 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(1), KARS(1) 2595538 3 3 3 0 1 0 2 0 0 0 0.371 0.468 1.000 86 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), UQCRC1(1) 2477500 3 3 3 0 0 1 1 0 1 0 0.561 0.470 1.000 87 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(2), RELN(3), VLDLR(2) 5248625 9 9 9 2 2 3 2 1 1 0 0.475 0.474 1.000 88 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB7(1), NDUFV1(1) 2614400 4 4 4 1 1 0 3 0 0 0 0.590 0.475 1.000 89 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(4) 2771408 4 4 4 1 2 0 1 0 1 0 0.540 0.478 1.000 90 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(3), SHMT2(1) 2075840 4 4 4 0 2 0 0 0 2 0 0.217 0.482 1.000 91 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), AOC2(1), CES1(3) 2257403 5 4 5 1 1 4 0 0 0 0 0.397 0.493 1.000 92 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 792665 1 1 1 0 0 1 0 0 0 0 0.725 0.505 1.000 93 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(1), SNCAIP(2) 2409348 3 3 3 0 1 2 0 0 0 0 0.365 0.507 1.000 94 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(3) 2929337 4 4 4 1 0 3 1 0 0 0 0.627 0.518 1.000 95 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 617514 1 1 1 0 0 1 0 0 0 0 0.740 0.521 1.000 96 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), KARS(1) 1759169 2 2 2 0 1 0 1 0 0 0 0.518 0.541 1.000 97 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(1), EIF4A1(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), PDPK1(1), PIK3R1(2), TSC2(2) 9264236 12 12 12 0 5 3 0 2 2 0 0.0269 0.542 1.000 98 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), IL4(1), IL6(1), IL9(1) 2286347 4 4 4 2 1 1 1 0 1 0 0.792 0.545 1.000 99 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(1), TPI1(1) 1465900 2 2 2 1 0 2 0 0 0 0 0.801 0.546 1.000 100 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), CYR61(1), JUND(1), WDR1(1) 4045828 4 4 4 0 0 0 3 0 1 0 0.463 0.564 1.000 101 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1) 1140023 1 1 1 0 1 0 0 0 0 0 0.670 0.564 1.000 102 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGAP3(2), ARFGEF2(1), COPA(2), GBF1(1), GPLD1(1), KDELR3(1) 6081977 9 9 9 2 3 4 0 0 2 0 0.347 0.574 1.000 103 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP2(1), MMP9(1) 2819815 4 4 4 1 1 2 1 0 0 0 0.568 0.583 1.000 104 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1) 1263898 1 1 1 1 0 1 0 0 0 0 0.956 0.595 1.000 105 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 1183547 1 1 1 1 1 0 0 0 0 0 0.914 0.596 1.000 106 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), PNMT(1), TPH1(1) 2291254 3 3 3 0 1 1 1 0 0 0 0.381 0.599 1.000 107 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 755394 1 1 1 1 1 0 0 0 0 0 0.931 0.599 1.000 108 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1) 985463 1 1 1 0 1 0 0 0 0 0 0.693 0.608 1.000 109 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(3), MAPK1(1), PRKCA(1) 3344886 5 5 5 1 3 1 0 1 0 0 0.426 0.611 1.000 110 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 1819908 2 2 2 1 0 1 0 0 1 0 0.800 0.616 1.000 111 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1) 1452430 1 1 1 0 0 0 0 0 1 0 1.000 0.625 1.000 112 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), PLA2G4A(2), PLCB1(2), PRKCA(1), PTGS1(1), PTK2(2), RAF1(1), SYK(2) 9144684 19 15 19 3 8 6 4 1 0 0 0.111 0.627 1.000 113 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY1(1), CRY2(2), PER1(2) 3208066 5 4 5 0 0 2 1 1 1 0 0.238 0.629 1.000 114 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR18(1), GPR39(1), GPR68(1), GPR75(1) 3658359 5 5 5 0 3 1 0 1 0 0 0.154 0.630 1.000 115 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(2) 5979913 10 9 10 2 5 2 2 1 0 0 0.304 0.634 1.000 116 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(1), HMBS(3) 2826730 4 4 4 0 3 0 1 0 0 0 0.271 0.635 1.000 117 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(1), APAF1(1), BAD(1), CASP7(1), PRKCA(1), PTK2(2), PXN(1), STAT1(1), TLN1(2) 7644778 11 11 11 0 2 6 1 1 1 0 0.0324 0.635 1.000 118 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), HEXB(1), HK2(1), HK3(2), PGM3(1) 6363560 7 7 7 1 2 1 0 1 3 0 0.402 0.638 1.000 119 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), HRAS(2), KLK2(1), MAPK1(1), RAF1(1) 3098548 6 6 6 2 3 0 2 0 1 0 0.705 0.646 1.000 120 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(1), AKT1(1), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(2), MAPK1(1), PDGFRA(3), PIK3R1(2), PLCB1(2), PRKCA(1), PTK2(2), RAC1(1) 9468862 21 16 21 3 9 6 2 1 3 0 0.103 0.660 1.000 121 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(2), DHRS7(1), DHRSX(1), PON1(1), PON2(1), RDH12(1) 3386138 8 7 8 2 2 2 3 0 1 0 0.404 0.663 1.000 122 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(2), SHC1(2), SOS1(1) 3304499 5 5 5 2 3 1 1 0 0 0 0.685 0.664 1.000 123 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN3(1), BCAR1(1), CSK(1), CTNNA2(4), PTK2(2), PXN(1) 6624854 10 9 10 0 5 1 0 2 2 0 0.0689 0.668 1.000 124 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), PANK1(1), PANK2(1), PANK3(1) 5240111 12 12 12 4 2 4 2 2 2 0 0.666 0.675 1.000 125 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), MARS(1), MARS2(2), MAT1A(1), PAPSS2(1), SEPHS1(1) 4648418 8 7 8 2 2 3 1 0 2 0 0.483 0.685 1.000 126 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(2), HSD17B3(1) 3027615 3 3 3 1 1 1 1 0 0 0 0.709 0.687 1.000 127 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(1), CDC25B(1), SHH(2) 3246524 4 4 4 1 3 0 1 0 0 0 0.544 0.688 1.000 128 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(3), AGTR1(2), NOS3(1) 3748323 6 5 6 1 2 1 1 1 1 0 0.535 0.689 1.000 129 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPNS1(1), EP300(4), MEF2D(2), NFATC1(2), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1) 9154563 16 13 16 2 8 2 3 3 0 0 0.0827 0.690 1.000 130 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3) 5622957 12 12 12 3 3 5 1 0 3 0 0.488 0.698 1.000 131 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3) 5622957 12 12 12 3 3 5 1 0 3 0 0.488 0.698 1.000 132 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3) 5622957 12 12 12 3 3 5 1 0 3 0 0.488 0.698 1.000 133 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BIK(1), BIRC2(1), CASP7(1), DFFA(1), ENDOG(1) 5100083 6 6 6 0 1 3 0 1 1 0 0.246 0.701 1.000 134 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 CDC25A(1), CDC25B(1), MYT1(1) 2810828 3 3 3 1 2 0 0 1 0 0 0.710 0.711 1.000 135 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), ILVBL(1), LARS(1), LARS2(1), PDHA2(1), VARS(2), VARS2(2) 6990242 10 9 10 2 2 2 2 2 2 0 0.447 0.711 1.000 136 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(1) 1218711 1 1 1 1 1 0 0 0 0 0 0.910 0.712 1.000 137 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 1587683 1 1 1 1 1 0 0 0 0 0 0.916 0.717 1.000 138 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH6(1) 2104922 2 2 2 0 1 1 0 0 0 0 0.488 0.718 1.000 139 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(4), CASP7(1), DFFA(1), LMNA(1) 7255592 10 10 10 2 3 4 1 2 0 0 0.381 0.719 1.000 140 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), MUT(1) 1841743 2 2 2 0 1 0 0 0 1 0 0.676 0.722 1.000 141 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), NFKB1(2), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(2), PXN(1), RAF1(1), RELA(1) 9551401 19 13 19 3 7 6 4 1 1 0 0.131 0.722 1.000 142 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), PIK3R4(1), PRKAA2(3), ULK3(1) 7938397 10 10 10 2 5 0 1 3 1 0 0.380 0.724 1.000 143 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1) 8785302 12 11 12 1 3 6 0 2 1 0 0.127 0.724 1.000 144 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(1), TNF(1) 2170252 3 3 3 2 1 0 1 0 1 0 0.855 0.727 1.000 145 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1B(1), PLCB1(2), TRH(1) 4189204 5 5 5 0 2 1 1 0 1 0 0.184 0.734 1.000 146 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO2(1), HAO1(2), MTHFD1(1), MTHFD1L(1) 4789886 5 5 5 0 1 3 1 0 0 0 0.195 0.735 1.000 147 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 BRCA1(1), CDC25A(1), CDC25B(1), CDKN1A(2), CHEK2(1), EP300(4), MDM2(1), MYT1(1), PRKDC(8), RPS6KA1(1), YWHAQ(1) 13031867 22 18 22 3 11 7 1 1 2 0 0.0997 0.741 1.000 148 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1R(2), TNF(1) 2465229 3 3 3 1 3 0 0 0 0 0 0.617 0.744 1.000 149 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 HBB(1), HMBS(3) 2916074 4 4 4 1 3 1 0 0 0 0 0.551 0.752 1.000 150 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACSL1(1), ACSL4(1), EHHADH(3), SLC25A20(1) 6312550 8 7 7 0 3 2 2 0 1 0 0.0923 0.753 1.000 151 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(3), AGTR1(2), CMA1(1), CTSA(1), ENPEP(1), MAS1(1), MME(2), THOP1(1) 7942417 12 10 12 2 4 5 2 1 0 0 0.217 0.753 1.000 152 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), CES1(3) 4051026 5 5 5 0 0 5 0 0 0 0 0.261 0.756 1.000 153 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCG2(1), BCHE(1), CES1(3), UGT1A1(3) 8533513 9 9 9 0 2 4 1 0 2 0 0.0618 0.758 1.000 154 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(1), B3GALT5(1), FUT1(1), FUT2(1), HEXB(1), NAGA(1), ST3GAL1(1), ST8SIA1(1) 4034701 10 10 10 4 4 3 0 1 2 0 0.686 0.758 1.000 155 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), GOT1(1), SULT4A1(1) 4708776 4 4 4 1 2 0 0 1 1 0 0.685 0.760 1.000 156 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(2), MAPK1(1), NFKB1(2), PLCB1(2), PRKCA(1), RAF1(1), RELA(1), TNF(1) 5829081 11 9 11 3 4 4 2 1 0 0 0.408 0.761 1.000 157 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGDH(1), UGT1A1(3), UGT2B15(2) 6581978 6 6 6 1 1 2 1 1 1 0 0.441 0.762 1.000 158 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), RDH12(1) 1805942 2 2 2 0 1 1 0 0 0 0 0.456 0.763 1.000 159 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHB(1), MECR(1) 3177337 3 3 3 1 1 0 1 0 1 0 0.700 0.763 1.000 160 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(2), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1) 3616628 8 8 8 4 3 1 1 0 3 0 0.926 0.768 1.000 161 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C6(2), C9(1) 4696127 4 4 4 1 1 1 0 0 2 0 0.570 0.770 1.000 162 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO2(1), HAO1(2), MTHFD1(1), MTHFD1L(1) 5018030 5 5 5 0 1 3 1 0 0 0 0.194 0.774 1.000 163 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGFR(3), HRAS(2), MAPK1(1), PTPRB(3), RAF1(1), SHC1(2), SOS1(1), SPRY3(1) 9350036 15 13 15 4 6 5 2 1 1 0 0.441 0.774 1.000 164 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), RPN1(1), UBE2A(1), UBE3A(1) 4829815 5 5 5 0 3 1 0 1 0 0 0.201 0.782 1.000 165 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), HSD11B1(1) 2591236 2 2 2 1 0 0 0 0 2 0 0.816 0.789 1.000 166 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 HRAS(2), IL3RA(2), JAK2(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1) 6629291 12 9 12 4 4 5 3 0 0 0 0.533 0.789 1.000 167 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), CASP7(1), DFFA(1), SCAP(1), SREBF2(3) 6911296 8 8 8 2 2 3 1 2 0 0 0.499 0.789 1.000 168 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(1), TPO(1) 3150428 3 3 3 1 1 2 0 0 0 0 0.634 0.790 1.000 169 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT3(2), B4GALT7(1), CHPF(1), CHST11(1), CHSY1(1), UST(1), XYLT1(4) 5305208 12 12 12 3 6 4 0 0 2 0 0.288 0.793 1.000 170 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST6GALNAC2(1), ST8SIA1(1) 2119498 4 4 4 2 2 1 0 0 1 0 0.738 0.793 1.000 171 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(3), BUB1(1), BUB1B(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(1), CDC25A(1), CDC25B(1), CDC6(2), CDC7(1), CDH1(3), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(1), DTX4(1), E2F3(1), EP300(4), ESPL1(1), GSK3B(1), HDAC5(2), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), MPEG1(4), PLK1(2), PRKDC(8), PTPRA(3), RB1(3), RBL1(2), SMAD4(4), TGFB1(1) 38509058 74 51 74 9 22 24 10 8 9 1 0.000775 0.794 1.000 172 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(1), GNAS(2) 3580468 5 4 5 2 0 2 2 1 0 0 0.810 0.794 1.000 173 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS7(1), DHRSX(1), ESCO1(5) 6194142 9 9 9 2 2 1 1 1 4 0 0.467 0.798 1.000 174 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(2), RELA(1), TNF(1) 3709613 4 4 4 1 1 3 0 0 0 0 0.535 0.799 1.000 175 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(1), AOC2(1), CES1(3), DDHD1(3), ESCO1(5) 9482813 14 12 14 2 3 5 2 1 3 0 0.211 0.800 1.000 176 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(2), ENPP3(2), NNMT(1), NNT(2), NT5M(1) 5458678 11 10 11 4 2 4 2 0 3 0 0.600 0.807 1.000 177 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR3(1), NTRK1(3), RAC1(1), WASF2(1), WASF3(1) 5706997 7 7 7 2 1 3 1 2 0 0 0.626 0.808 1.000 178 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(3), KRT18(1), PRKCA(1), ROCK1(4), ROCK2(1), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1), YWHAQ(1) 19011140 32 25 32 4 7 6 3 6 10 0 0.109 0.814 1.000 179 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(3), KRT18(1), PRKCA(1), ROCK1(4), ROCK2(1), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1), YWHAQ(1) 19011140 32 25 32 4 7 6 3 6 10 0 0.109 0.814 1.000 180 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR3(1), RAC1(1) 3033339 2 2 2 0 0 0 1 1 0 0 0.626 0.815 1.000 181 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(3), PDHA2(1) 2635642 5 5 5 2 1 1 0 1 2 0 0.627 0.818 1.000 182 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(1), MBTPS2(1), SCAP(1), SREBF2(3) 4534438 8 8 8 3 3 1 1 1 2 0 0.707 0.820 1.000 183 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 GRM1(4), PLCB1(2), PPP1CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(1) 6019049 10 10 9 3 3 1 1 3 2 0 0.528 0.832 1.000 184 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(1), EGFR(3), MET(1), PDGFRA(3), PRKCA(1), SH3GLB2(1) 7283828 11 10 11 3 4 3 2 1 1 0 0.506 0.834 1.000 185 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 NFKB1(2), RELA(1), TNFSF11(1) 4166141 4 4 4 0 0 3 0 1 0 0 0.349 0.834 1.000 186 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(1) 1866943 1 1 1 0 0 0 0 1 0 0 0.846 0.838 1.000 187 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1) 2088119 1 1 1 0 0 0 0 0 1 0 1.000 0.841 1.000 188 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), FUT8(1), ST3GAL1(1) 2967521 8 7 8 3 4 3 0 0 1 0 0.622 0.843 1.000 189 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 NFKB1(2), RELA(1) 3367885 3 3 3 0 0 3 0 0 0 0 0.420 0.843 1.000 190 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX3(1), ELOVL6(1), FADS1(1), FADS2(2), FASN(1), SCD(1) 5454421 9 9 9 3 1 4 2 1 1 0 0.572 0.844 1.000 191 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), EGFR(3), HRAS(2), NFKB1(2), PLCG1(1), PRKCA(1), RELA(1) 7704042 12 11 12 3 2 7 1 2 0 0 0.379 0.846 1.000 192 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(3), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), IGF1R(2), KLK2(1), MAPK1(1), PDGFRA(3), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1) 11805436 24 22 24 5 7 9 4 2 2 0 0.249 0.850 1.000 193 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1) 3274110 2 2 2 0 0 1 0 1 0 0 0.625 0.850 1.000 194 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD8A(1), IL6(1) 2316921 2 2 2 4 0 1 0 0 1 0 0.990 0.850 1.000 195 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CRY1(1), CRY2(2), DAZAP2(1), EIF4G2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(2), NCOA4(2), NR1D2(1), PER1(2), PER2(1), SF3A3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(1), ZFR(1) 13714085 23 18 23 4 3 7 4 4 5 0 0.251 0.851 1.000 196 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGTR1(2), CMA1(1), COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1) 9403173 9 8 9 1 4 2 2 1 0 0 0.154 0.852 1.000 197 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(2), PAFAH2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLD1(2), PPAP2B(1) 8717176 17 15 17 4 7 2 2 3 3 0 0.338 0.853 1.000 198 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMD1(1), PSMD2(1), PSMD6(1) 5994365 5 5 5 0 1 1 1 2 0 0 0.279 0.856 1.000 199 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 CDC25A(1), CDC25B(1), CDK4(1), MYT1(1), RB1(3) 3924097 7 6 7 3 3 1 1 1 0 1 0.737 0.858 1.000 200 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), GRIN1(1), JAK2(2), NFKB1(2), RELA(1), SOD2(1) 4771465 10 7 10 3 4 4 0 0 2 0 0.628 0.862 1.000 201 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2349839 1 1 1 0 0 0 0 1 0 0 0.845 0.862 1.000 202 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), ENDOG(1), TOP2A(1), TOP2B(1) 3397370 5 5 5 2 2 2 0 0 1 0 0.826 0.863 1.000 203 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(5), EP300(4), NFKB1(2), RELA(1), RIPK1(1), TNF(1) 8416946 14 14 14 4 5 5 2 1 1 0 0.478 0.867 1.000 204 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), DAXX(1), FASLG(1), MAPKAPK3(1), TNF(1) 4252687 5 5 5 2 1 1 2 0 1 0 0.840 0.869 1.000 205 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(1) 1758982 2 2 2 3 1 0 0 0 1 0 0.970 0.872 1.000 206 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY1(1), CRY2(2), NPAS2(1), PER1(2), PER2(1), PER3(3) 6412615 10 8 10 2 1 3 1 3 2 0 0.361 0.872 1.000 207 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO2(1), FH(1) 3012886 2 2 2 0 0 0 1 1 0 0 0.645 0.873 1.000 208 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND3(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), RB1(3), RBL1(2) 6058319 16 12 16 5 5 4 1 0 5 1 0.647 0.874 1.000 209 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(2), DVL1(1), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(1), NFKB1(2), PDPK1(1), PIK3R1(2), RELA(1) 10144622 17 15 17 4 7 6 2 0 2 0 0.234 0.876 1.000 210 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), IL12RB2(4), IL4(1), IL4R(1) 4746697 7 6 7 3 2 4 0 0 1 0 0.782 0.877 1.000 211 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(1), AKT2(1), BAD(1), BTK(1), CDKN2A(1), GSK3A(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PPP1R13B(1), RPS6KA1(1), SHC1(2), SOS1(1), YWHAQ(1) 12438070 18 18 18 4 7 5 1 0 5 0 0.264 0.877 1.000 212 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT2(1), ST8SIA1(1) 2304587 4 4 4 4 0 3 0 0 1 0 0.950 0.879 1.000 213 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(5), EP300(4), MAP3K7(2), NFKB1(2), RELA(1), TGFBR1(2), TNF(1) 11156944 17 14 17 3 7 5 2 1 2 0 0.212 0.885 1.000 214 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(2), JAK2(2), STAT1(1) 3067494 5 4 5 2 1 2 2 0 0 0 0.735 0.886 1.000 215 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPT(2), ENPP1(2), ENPP3(2), RFK(1) 5632656 8 8 8 3 2 2 1 1 2 0 0.679 0.888 1.000 216 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD2(4) 2168850 4 4 4 3 1 2 0 0 1 0 0.882 0.889 1.000 217 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), CDK4(1), CDKN1A(2), MDM2(1), RB1(3) 4135985 8 5 8 2 3 2 1 0 1 1 0.496 0.889 1.000 218 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), LIMK1(1), MAPK1(1), MYL2(1), PLCB1(2), PRKCA(1), PTK2(2), RAF1(1), ROCK2(1) 9389555 17 13 17 3 5 6 3 2 1 0 0.268 0.891 1.000 219 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD8A(1), ITGAL(3), ITGB2(2), PTPRC(3) 4022813 9 8 9 4 3 2 1 2 1 0 0.697 0.892 1.000 220 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(1), MAP3K1(1), MAPK1(1), NFKB1(2), PIK3R1(2), RB1(3), RELA(1), SP1(1) 6469029 12 8 12 2 3 7 1 0 0 1 0.218 0.892 1.000 221 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(1), CCR4(1), CCR7(1), IL12RB2(4), IL4(1), IL4R(1), TGFB1(1), TGFB2(1) 7473809 11 10 11 3 2 7 1 0 1 0 0.420 0.892 1.000 222 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), ARSE(2), CYP11B2(1), CYP19A1(2), HSD11B1(1), HSD17B3(1), METTL6(1), PRMT3(1), PRMT5(1), STS(2), SULT1E1(2), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1) 18806170 32 26 32 6 6 9 3 5 9 0 0.137 0.893 1.000 223 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(1), PRKCA(1) 2512828 2 2 2 1 1 0 0 1 0 0 0.850 0.893 1.000 224 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(3), CCNA1(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), DHFR(1), GSK3B(1), RB1(3), TGFB1(1), TGFB2(1) 8700334 20 14 20 6 5 3 3 0 8 1 0.681 0.896 1.000 225 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(2), CYP1A2(1), CYP2C19(1), CYP2C8(2), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), RDH12(1) 8971775 14 12 14 3 4 3 5 1 1 0 0.312 0.897 1.000 226 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), RB1(3) 3196386 4 4 4 2 0 2 1 0 0 1 0.792 0.900 1.000 227 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(1), FUT2(1), HEXB(1), NAGA(1), ST3GAL1(1), ST8SIA1(1) 3802566 8 8 8 4 3 3 0 0 2 0 0.789 0.901 1.000 228 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), DAG1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), PDE6B(1), PDE6C(1), SLC6A13(1), TF(2) 13460423 17 16 17 3 6 5 1 1 4 0 0.245 0.903 1.000 229 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3) 5988132 12 12 12 4 3 5 1 0 3 0 0.665 0.904 1.000 230 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1) 4353453 7 7 7 3 3 2 0 1 1 0 0.738 0.906 1.000 231 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1), GSK3B(1) 3482831 2 2 2 0 0 0 1 0 1 0 0.545 0.907 1.000 232 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), GNA12(1), PRKAG1(2) 3782013 4 4 4 2 0 2 2 0 0 0 0.799 0.911 1.000 233 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ME1(1), PC(1) 3475105 2 2 2 1 0 1 0 0 1 0 0.761 0.913 1.000 234 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(3) 4569710 8 8 8 3 1 4 2 1 0 0 0.668 0.920 1.000 235 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGAL(3), ITGB2(2), SELE(1) 4531714 6 5 6 2 3 1 1 1 0 0 0.628 0.922 1.000 236 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(3), SIRT2(1) 4441263 5 5 5 2 1 2 1 1 0 0 0.740 0.923 1.000 237 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(3), FCGR3A(1), TGFB1(1), TGFB2(1), TNF(1), TNFSF8(1) 4978500 8 7 8 2 3 2 2 1 0 0 0.413 0.925 1.000 238 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(1) 2568403 1 1 1 0 1 0 0 0 0 0 0.691 0.927 1.000 239 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(1), BAD(1), MUSK(2), PIK3R1(2), PTK2(2) 5348683 8 6 8 1 4 4 0 0 0 0 0.170 0.928 1.000 240 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), CD38(1), ENPP1(2), ENPP3(2), NADK(2), NNMT(1), NNT(2), NT5C2(2), NT5M(1), NUDT12(1) 8082188 16 13 16 5 4 6 2 0 4 0 0.506 0.933 1.000 241 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 RB1(3) 3087197 3 3 3 2 0 1 1 0 0 1 0.871 0.933 1.000 242 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), FH(1) 3518720 2 2 2 0 0 0 1 1 0 0 0.655 0.934 1.000 243 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRB(1), COX15(1), CP(1), CPOX(1), EPRS(2), HMBS(3), HMOX1(1), HMOX2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1) 15792103 27 23 27 5 10 6 3 4 4 0 0.142 0.935 1.000 244 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(1), DHFR(1) 2483012 5 5 5 6 2 1 0 1 1 0 0.990 0.935 1.000 245 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1), GOT1(1) 2918230 2 2 2 5 1 0 0 0 1 0 0.999 0.937 1.000 246 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12RB2(4), JAK2(2), STAT4(3), TYK2(1) 5505928 10 8 10 5 1 4 2 0 3 0 0.831 0.937 1.000 247 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(1), GSK3B(1), PPP1CA(1) 4309892 6 6 6 3 1 0 1 2 2 0 0.862 0.939 1.000 248 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 JAK1(2), STAT1(1), TYK2(1) 4068031 4 4 4 2 0 1 2 0 1 0 0.839 0.939 1.000 249 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(2), GOT1(1), PAH(1), YARS2(1) 3255049 5 4 5 2 4 0 0 0 1 0 0.644 0.939 1.000 250 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 PIK3R1(2), RAC1(1), SYK(2), VAV1(2) 6147562 7 7 7 2 4 1 1 1 0 0 0.502 0.941 1.000 251 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL6(1), IL9(1), TGFB1(1), TGFB2(1) 3112731 5 5 5 4 0 2 2 0 1 0 0.958 0.944 1.000 252 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGDIB(1), CASP1(4) 4828216 6 6 6 3 2 2 1 1 0 0 0.804 0.945 1.000 253 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1B(1), ADH6(1), DHRS1(2), DHRS7(1), DHRSX(1), ESCO1(5) 9352191 11 10 11 2 3 2 1 1 4 0 0.309 0.945 1.000 254 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(3), HADHB(1), IVD(1), MUT(1) 13491963 23 20 22 5 6 9 5 1 2 0 0.203 0.946 1.000 255 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), MAP3K1(1), NFKB1(2), RELA(1), TNFAIP3(1) 6807310 6 5 6 1 0 5 0 0 1 0 0.414 0.947 1.000 256 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRA(1), IL4(1), IL6(1), LTA(1), TGFB1(1), TGFB2(1), TNF(1) 4996431 7 6 7 3 3 3 1 0 0 0 0.687 0.949 1.000 257 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(3), L1CAM(3), SELP(2) 5899183 9 8 9 3 4 1 2 0 2 0 0.632 0.949 1.000 258 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(1) 2950135 1 1 1 0 0 0 0 0 1 0 0.672 0.949 1.000 259 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), FPR1(1), GNB1(1), GNGT1(1), HRAS(2), MAP3K1(1), MAPK1(1), NCF1(1), NCF2(4), NFATC1(2), NFATC2(1), NFKB1(2), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(1) 14328243 27 20 27 5 9 9 4 4 1 0 0.111 0.949 1.000 260 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(3), BRCA1(1), CDKN1A(2), CHEK2(1), MDM2(1), NFKB1(2), RAD51(1), RELA(1) 8530187 12 7 12 1 3 6 1 0 2 0 0.171 0.952 1.000 261 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(1) 2983406 3 3 3 2 2 0 0 0 1 0 0.901 0.952 1.000 262 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(1), GSK3B(1), IGF1R(2), INPPL1(1), PDPK1(1), PIK3R1(2) 6259378 8 7 8 2 3 3 1 0 1 0 0.442 0.952 1.000 263 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(2) 3153629 2 2 2 1 0 1 0 0 1 0 0.937 0.953 1.000 264 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(5), EP300(4), NCOA1(1), PPARG(1) 6923846 11 10 11 4 5 2 2 1 1 0 0.635 0.956 1.000 265 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1) 3935776 7 6 7 3 1 3 2 0 1 0 0.743 0.956 1.000 266 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1) 3935776 7 6 7 3 1 3 2 0 1 0 0.743 0.956 1.000 267 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), LTA(1), MAP3K1(1), NFKB1(2), RELA(1), RIPK1(1), TNFAIP3(1), TRAF1(1), TRAF2(2) 8430806 11 8 11 2 1 8 1 0 1 0 0.276 0.957 1.000 268 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(1), AKT2(1), BAD(1), BCR(1), BTK(1), CD81(1), CSK(1), DAG1(2), GSK3A(1), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP4K1(1), MAPK1(1), NFATC1(2), NFATC2(1), PDK1(1), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(3), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2) 27014247 43 40 43 8 19 8 5 4 7 0 0.0568 0.957 1.000 269 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 DIAPH1(1), GSN(2), HRAS(2), MAPK1(1), MYL2(1), MYLK(4), PIK3R1(2), PTK2(2), PXN(1), RAF1(1), ROCK1(4), SHC1(2), TLN1(2) 13175130 25 22 25 6 11 3 5 2 4 0 0.235 0.958 1.000 270 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(2), PTPRU(3), STAT1(1), TYK2(1) 4704281 7 7 7 3 3 1 2 0 1 0 0.726 0.960 1.000 271 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(1), AKT2(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CD(1), PIK3R1(2), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(1) 12986073 26 25 26 7 9 9 2 1 5 0 0.383 0.961 1.000 272 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(1), DHRS1(2), DHRS7(1), DHRSX(1), EHHADH(3), ESCO1(5), FN3K(1) 9721211 15 13 15 4 3 5 2 1 4 0 0.431 0.962 1.000 273 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGTR1(2), ATF2(1), EGFR(3), HRAS(2), MAP2K4(1), MAP3K1(1), MAPK1(1), MEF2C(2), MEF2D(2), PRKCA(1), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 12538042 24 21 24 6 10 6 5 3 0 0 0.255 0.964 1.000 274 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(2), JAK2(2), PLA2G2A(1), PTPRU(3), STAT1(1) 4299247 9 7 9 3 4 2 2 1 0 0 0.604 0.966 1.000 275 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), CDC27(1), CUL2(3), CUL3(3), FBXW11(1), FZR1(3), TCEB2(1), UBA1(1), VHL(1), WWP1(1) 15012867 23 22 23 5 3 4 10 1 5 0 0.277 0.969 1.000 276 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C6(2), IL6(1), ITGAL(3), ITGB2(2), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 9275960 14 12 14 4 6 4 1 2 1 0 0.383 0.969 1.000 277 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGEF1(3), GNA12(1), GNB1(1), GNGT1(1), MYL2(1), MYLK(4), PLCB1(2), PRKCA(1), ROCK1(4) 7733826 18 16 18 5 4 6 3 3 2 0 0.503 0.970 1.000 278 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(1), CABIN1(2), CAMK1(2), HDAC5(2), IGF1R(2), MEF2C(2), MEF2D(2), NFATC1(2), NFATC2(1), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1) 12275587 21 17 21 4 11 3 3 3 1 0 0.133 0.970 1.000 279 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CSK(1), HRAS(2), MAPK1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(4), SHC1(2), SOS1(1), TLN1(2) 17736887 21 19 21 4 7 3 6 1 4 0 0.244 0.970 1.000 280 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 CHEK2(1) 3327851 1 1 1 1 0 1 0 0 0 0 0.969 0.971 1.000 281 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), P4HB(1), SLC23A2(1) 9359629 8 7 8 1 3 3 0 1 1 0 0.236 0.971 1.000 282 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(1), C3(1), C6(2), C8B(1), C9(1), MASP1(1) 7787995 7 7 7 2 2 1 2 0 2 0 0.531 0.971 1.000 283 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(1), APC(2), AR(1), ASAH1(2), DAG1(2), EGFR(3), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(1), PIK3CD(1), PIK3R1(2), PITX2(1), RAF1(1) 18654493 30 28 30 6 15 8 2 0 5 0 0.124 0.971 1.000 284 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNF(1), TRAF2(2) 3163115 4 3 4 2 1 2 1 0 0 0 0.766 0.972 1.000 285 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), HEXB(1), LCT(3) 5405412 7 6 7 3 3 2 1 0 1 0 0.719 0.972 1.000 286 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(1), ADH1B(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), CYP7A1(3), HADHB(1), SOAT2(1) 8717159 17 16 17 5 3 7 4 2 1 0 0.418 0.973 1.000 287 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(3), ITGB2(2), PTPRC(3) 4218689 8 7 8 4 3 2 1 2 0 0 0.775 0.974 1.000 288 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(1), GCK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKFB4(1), PFKM(1), PFKP(1), PMM1(1), TPI1(1) 8996540 12 12 12 4 2 4 2 2 2 0 0.543 0.974 1.000 289 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2) 5074663 3 3 3 0 2 0 0 1 0 0 0.402 0.974 1.000 290 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 HSPA1A(1), JAK2(2), NFKB1(2), RB1(3), RELA(1), TNF(1) 6538847 10 7 10 3 3 5 1 0 0 1 0.427 0.975 1.000 291 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN3(1), CAPNS1(1), PTK2(2), PXN(1), RAC1(1), SPTAN1(1), TLN1(2) 10735196 9 9 9 1 2 3 2 0 2 0 0.231 0.975 1.000 292 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), POLG(1), RRM1(2) 4737517 4 4 4 6 0 2 0 0 2 0 0.997 0.975 1.000 293 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PGM1(1), PYGL(2), TPI1(1) 5041735 7 7 7 3 2 4 1 0 0 0 0.643 0.977 1.000 294 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 FBL(2) 3355765 2 2 2 1 2 0 0 0 0 0 0.783 0.977 1.000 295 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), NFATC1(2), NFATC2(1), PRKAR1A(1), PRKAR1B(1) 4588449 6 6 6 3 2 0 2 2 0 0 0.815 0.979 1.000 296 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MARS2(2), MAT1A(1) 6538480 9 8 9 5 1 3 2 0 3 0 0.874 0.980 1.000 297 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 BRCA1(1), BRCA2(5), CHEK2(1), FANCA(1), FANCF(1), FANCG(1), HUS1(1), RAD17(1), RAD51(1), TREX1(1) 13834996 14 13 14 3 1 6 2 1 4 0 0.604 0.980 1.000 298 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CMAS(1), CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(1), HK2(1), HK3(2), NAGK(1), PGM3(1) 10771898 11 10 11 3 4 1 1 2 3 0 0.571 0.981 1.000 299 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(4), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(3), MUT(1), SUCLG1(1) 12411285 17 14 17 4 3 7 4 1 2 0 0.337 0.982 1.000 300 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), FCER1A(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), NFATC1(2), NFATC2(1), PAK2(1), PIK3R1(2), PLA2G4A(2), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2) 15290808 28 23 28 7 13 5 4 5 1 0 0.250 0.983 1.000 301 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(2), IL12RB2(4), JAK2(2), STAT4(3), TYK2(1) 6986044 12 10 12 7 2 5 2 0 3 0 0.894 0.983 1.000 302 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(2), JAK2(2), JAK3(2), MAPK1(1), TYK2(1) 3840914 8 7 8 5 3 3 1 0 1 0 0.886 0.983 1.000 303 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(2), DHRS7(1), DHRSX(1), METTL6(1), PRMT3(1), PRMT5(1) 5646678 7 7 7 6 1 1 1 1 3 0 0.969 0.984 1.000 304 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(3), MAP3K1(1), NCOR2(1), THRA(2) 6521453 7 7 7 2 2 4 0 0 1 0 0.440 0.984 1.000 305 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), ILVBL(1), PANK1(1), PANK2(1), PANK3(1) 6508610 13 13 13 5 2 5 2 2 2 0 0.738 0.984 1.000 306 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(1), C3(1), C6(2), C9(1) 6553759 5 5 5 2 1 1 1 0 2 0 0.703 0.985 1.000 307 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 METTL6(1), PRMT3(1), PRMT5(1) 5278061 3 3 3 4 0 0 0 1 2 0 0.993 0.985 1.000 308 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), TPI1(1) 3502329 3 3 3 4 1 1 0 0 1 0 0.980 0.986 1.000 309 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IRAK1(1), MAP3K1(1), MAP3K7(2), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TNFAIP3(1) 9136954 10 9 10 3 3 4 1 0 2 0 0.547 0.986 1.000 310 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(2), SYT1(1) 8183671 11 11 11 4 1 2 2 3 3 0 0.738 0.986 1.000 311 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(3), FASN(1), OXSM(1) 6025892 9 9 9 4 3 4 1 1 0 0 0.723 0.987 1.000 312 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO2(1), FH(1), PC(1), SUCLG1(1) 7384514 4 4 4 1 0 0 1 1 2 0 0.588 0.987 1.000 313 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(1), TPO(1) 3628981 3 3 3 2 1 2 0 0 0 0 0.826 0.987 1.000 314 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), SNAP25(1), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1) 6295674 7 6 7 2 3 0 1 1 2 0 0.634 0.988 1.000 315 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(1), UBE2I(1), UBE3A(1) 3948117 3 3 3 2 2 1 0 0 0 0 0.825 0.988 1.000 316 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP7(1), DAXX(1), DFFA(1), FAF1(2), LMNA(1), MAP2K4(1), MAP3K1(1), MAP3K7(2), PAK2(1), PRKDC(8), PTPN13(2), RB1(3), RIPK2(2), SPTAN1(1) 15304477 28 21 28 6 10 9 4 2 2 1 0.192 0.988 1.000 317 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), ASAH1(2), CERK(1), CREB3(1), DAG1(2), EPHB2(3), ITPKB(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2) 10769696 19 16 19 5 10 3 0 1 5 0 0.461 0.989 1.000 318 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 NOTCH1(2), PSEN1(1) 3578052 3 3 3 2 1 1 1 0 0 0 0.841 0.989 1.000 319 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10A(1), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL8(1), RPS11(2) 8577259 11 11 11 3 3 2 1 2 3 0 0.737 0.989 1.000 320 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CFL1(1), CHN1(1), LIMK1(1), MAP3K1(1), MYL2(1), MYLK(4), NCF2(4), PDGFRA(3), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), TRIO(4), VAV1(2) 12277072 28 24 28 8 12 4 5 3 4 0 0.363 0.989 1.000 321 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 BAD(1), CREB3(1), EEF2K(3), MAPK1(1), NFKB1(2), RPS6KA1(1), SHC1(2), SOS1(1) 10514337 12 11 12 4 5 6 0 0 1 0 0.549 0.990 1.000 322 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3005508 5 5 5 3 1 2 1 1 0 0 0.862 0.990 1.000 323 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3005508 5 5 5 3 1 2 1 1 0 0 0.862 0.990 1.000 324 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(3), DBH(1), DDC(1), GAD2(4), PAH(1), PNMT(1), TPH1(1) 5442300 13 13 13 7 4 4 1 1 3 0 0.795 0.990 1.000 325 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(2), HEXB(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1), ST8SIA1(1) 6171525 12 10 12 8 8 2 0 0 2 0 0.902 0.991 1.000 326 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(2), B4GALT2(2), FUT1(1), FUT2(1), FUT3(1), FUT6(1), ST8SIA1(1) 6085220 13 12 13 5 4 5 0 2 1 1 0.643 0.991 1.000 327 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MAPKAPK5(1), NFKB1(2), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(2), TRAF5(1) 11905650 16 11 16 2 6 5 0 2 3 0 0.124 0.991 1.000 328 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), FH(1), PC(1), PDHA2(1), PDHX(1), PDK1(1), PDK4(1), PDP2(1), SUCLG1(1) 10607244 10 10 10 3 0 5 1 1 3 0 0.493 0.991 1.000 329 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA3(1) 4481726 1 1 1 0 0 0 0 0 1 0 0.668 0.991 1.000 330 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), MAP2K4(1), MAP3K7(2), NFKB1(2), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(2) 10257453 12 11 12 4 2 4 1 2 3 0 0.642 0.992 1.000 331 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(1), AKT1(1), BAD(1), IGF1R(2), IL3RA(2), PIK3R1(2), PRKAR1A(1), PRKAR1B(1) 7424601 11 10 11 4 2 5 3 1 0 0 0.622 0.992 1.000 332 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(5), DFFA(1), GZMA(1) 3983773 7 7 7 4 3 2 0 1 1 0 0.879 0.992 1.000 333 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), PPP1CA(1), PRKAG1(2) 6786625 7 7 7 4 1 1 2 1 2 0 0.874 0.993 1.000 334 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), AGXT(1), ASL(1), CAD(3), GAD2(4), GOT1(1), PC(1) 9786827 13 13 13 8 5 3 0 0 5 0 0.902 0.993 1.000 335 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT1(2), B4GALT2(2), B4GALT5(1), FUT8(1), MAN1A1(2), MGAT1(1), MGAT5(1), RPN1(1), ST6GAL1(1) 7505229 12 11 12 4 6 5 0 0 1 0 0.445 0.993 1.000 336 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MARS2(2), MAT1A(1) 7803846 9 8 9 6 1 3 2 0 3 0 0.935 0.993 1.000 337 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CD74(1), CD8A(1), CD8B(1), CIITA(1), CTSL1(1), HLA-DRA(1), HLA-F(1), HLA-G(4), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), KIR2DL1(1), KIR3DL2(1), KIR3DL3(1), LTA(1), NFYA(1), NFYC(2), PSME2(1), RFXANK(1), TAP1(1), TAP2(1) 17422941 29 20 29 7 5 12 5 3 4 0 0.196 0.993 1.000 338 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1) 4137006 2 2 2 2 0 1 0 0 1 0 0.892 0.994 1.000 339 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(1), F2(1), FGA(2), PLAT(1), PLAU(2), PLG(2), SERPINB2(1) 5011961 11 10 11 7 2 2 3 3 1 0 0.976 0.994 1.000 340 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(3), JAK1(2), JAK2(2), JAK3(2), STAT1(1), STAT5A(1), STAT5B(1), TYK2(1) 6341030 13 10 13 5 3 5 3 0 2 0 0.637 0.994 1.000 341 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CASP7(1), DFFA(1), LMNA(1), NFKB1(2), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(2) 12567213 14 12 14 3 1 10 1 1 1 0 0.295 0.994 1.000 342 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(1), ADH1B(1), ADH6(1), AKR1B10(1), AKR1C4(1), AKR1D1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CYP7A1(3), HADHB(1), RDH12(1), SOAT2(1) 11908480 18 16 17 5 5 7 4 1 1 0 0.332 0.994 1.000 343 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F3(1), F5(5), F7(1), FGA(2), PROS1(2) 6128475 13 12 13 5 3 6 3 1 0 0 0.699 0.995 1.000 344 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), HRAS(2), MAP3K1(1), MAPK1(1), MAPK8IP3(2), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2), VAV2(1), VAV3(4) 12029925 25 22 24 8 8 6 5 2 4 0 0.544 0.995 1.000 345 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CBS(1), MARS(1), MARS2(2), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(1), PRMT5(1), SEPHS1(1), SEPHS2(3) 9367323 14 13 14 6 3 3 2 2 4 0 0.798 0.995 1.000 346 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), DNMT1(1), MTNR1A(1), MTNR1B(1), PTGER2(1), TBXA2R(2) 4230328 7 7 7 4 3 2 1 0 1 0 0.770 0.995 1.000 347 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(1), ABCC1(1), ABCC3(2) 5356072 8 8 8 5 3 2 1 1 1 0 0.881 0.996 1.000 348 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IL4(1), MAP3K1(1), MAP3K5(1), NFKB1(2), RELA(1), TRAF2(2) 7271898 9 7 9 4 2 6 0 1 0 0 0.745 0.996 1.000 349 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), GNAS(2), HRAS(2), MAPK1(1), PIK3R1(2), PRKAR1A(1), PRKAR1B(1), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1) 10124755 20 18 20 6 6 6 4 4 0 0 0.512 0.996 1.000 350 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(2), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(2), PSEN1(1) 7557583 9 9 9 4 4 1 2 0 2 0 0.687 0.996 1.000 351 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(1), C3(1), C6(2), C9(1), MASP1(1), MASP2(1) 7986099 7 7 7 3 1 1 2 1 2 0 0.744 0.996 1.000 352 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH6(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2) 4975333 6 6 5 3 3 2 1 0 0 0 0.737 0.996 1.000 353 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT7(1), B4GALT1(2), B4GALT2(2), CHST4(1), FUT8(1), ST3GAL1(1) 4697675 9 7 9 4 5 4 0 0 0 0 0.694 0.997 1.000 354 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(1), CSNK2A1(1), HRAS(2), IL6(1), IL6ST(2), JAK1(2), JAK2(2), JAK3(2), RAF1(1), SHC1(2), SOS1(1) 8351601 17 16 17 9 5 6 3 0 3 0 0.927 0.997 1.000 355 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), HMGCS1(2), SQLE(1) 4953106 4 3 4 5 2 1 0 0 1 0 0.983 0.997 1.000 356 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHAT(3), DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), ESCO1(5), ETNK1(1), ETNK2(1), GNPAT(1), GPAM(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLD1(2), PPAP2B(1), PTDSS1(1) 24643723 40 34 40 9 12 6 5 5 12 0 0.188 0.997 1.000 357 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACO2(1), ACSS1(1), FH(1) 4658270 3 3 3 2 1 0 1 1 0 0 0.867 0.997 1.000 358 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(5), DAXX(1), HRAS(2), PML(1), RB1(3), SP100(1), TNF(1) 6837685 14 14 14 6 5 2 4 1 1 1 0.733 0.998 1.000 359 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(1), AKT2(1), BAD(1), BCR(1), BTK(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(2), MAPK1(1), NFKB1(2), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2) 19029736 29 25 29 7 14 8 3 1 3 0 0.190 0.998 1.000 360 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACADS(2), ACAT1(1), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH1B1(1), ALDH5A1(1), ALDH7A1(2), DDHD1(3), EHHADH(3), GAD2(4), HMGCS1(2), HMGCS2(1), ILVBL(1), PDHA2(1), RDH12(1) 15241847 27 25 25 8 9 11 4 0 3 0 0.287 0.998 1.000 361 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), ACY3(1), AGXT(1), ASL(1), CAD(3), DARS2(1), DLAT(1), GAD2(4), GOT1(1), NARS2(1), PC(1), PDHA2(1) 14211877 18 17 18 8 7 4 0 0 7 0 0.707 0.998 1.000 362 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(1), EP300(4), NOS3(1), P4HB(1), VHL(1) 6381939 9 7 9 4 4 3 1 0 1 0 0.780 0.998 1.000 363 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR3(1), AKT1(1), DAG1(2), DGKA(2), ETFA(1), ITGA9(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NR1I3(1), PDE3B(1), PIK3CD(1), PIK3R1(2) 17484590 22 21 22 5 8 6 0 2 6 0 0.283 0.998 1.000 364 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ATP7B(2), NDUFA10(2), NDUFB7(1), NDUFV1(1), SHMT1(3), UQCRC1(1), UQCRFS1(1) 14308094 21 19 21 5 4 9 4 1 3 0 0.343 0.998 1.000 365 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(1), AKT2(1), ANKRD6(1), APC(2), AXIN2(2), DACT1(3), DKK2(2), DVL1(1), GSK3A(1), GSK3B(1), LRP1(3), NKD2(1), PSEN1(1), PTPRA(3), WIF1(2) 14597299 25 20 25 7 10 6 2 3 4 0 0.372 0.998 1.000 366 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), HEXB(1), LCT(3), SPAM1(1) 7692969 8 7 8 4 3 3 1 0 1 0 0.801 0.998 1.000 367 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), PIGT(1) 8940781 9 8 9 4 3 2 2 0 2 0 0.808 0.998 1.000 368 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT2(1), DAG1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), NFKB1(2), PDK1(1), PHKA2(1), PIK3CB(2), PITX2(1), PLD1(2), VN1R1(2) 16891093 24 22 24 6 8 8 2 0 6 0 0.297 0.998 1.000 369 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 CRK(1), HGF(2), HRAS(2), MAP4K1(1), MAPK1(1), MET(1), PIK3R1(2), PTK2(2), PXN(1), RAF1(1), SOS1(1) 14881063 15 14 15 4 7 4 4 0 0 0 0.329 0.998 1.000 370 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP6(1), ARHGEF1(3), ARHGEF11(3), ARHGEF5(1), CFL1(1), DIAPH1(1), GSN(2), LIMK1(1), MYL2(1), MYLK(4), ROCK1(4), TLN1(2) 16938665 25 22 25 7 4 4 5 3 9 0 0.546 0.998 1.000 371 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), HEXB(1), LCT(3), NEU1(1) 6250370 6 5 6 4 2 2 1 0 1 0 0.912 0.998 1.000 372 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 CASP1(4), CASP7(1), RERE(3), WWP1(1) 9002558 9 9 9 4 3 3 2 1 0 0 0.733 0.999 1.000 373 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(3), EHMT2(1), PLOD1(2), PLOD3(1), SHMT1(3), SHMT2(1) 13919674 22 18 22 6 4 8 5 1 4 0 0.362 0.999 1.000 374 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(3), HADHB(1), HMGCS1(2), HMGCS2(1), IVD(1), MUT(1) 16125223 23 21 21 6 8 9 4 0 2 0 0.290 0.999 1.000 375 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4(1), IL4R(1), IRS1(2), JAK1(2), JAK3(2), SHC1(2), STAT6(1) 5563479 12 12 12 5 4 5 1 1 1 0 0.786 0.999 1.000 376 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(2), CREBBP(5), CSNK2A1(1), DVL1(1), FZD1(2), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(1), WIF1(2) 10459755 19 17 19 7 7 3 3 1 5 0 0.700 0.999 1.000 377 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(1), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(1), DDC(1), FAH(1), GOT1(1), HGD(1), HPD(1), PNMT(1), TPO(1) 11888382 16 15 16 7 5 5 1 0 5 0 0.700 0.999 1.000 378 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), HRAS(2), MAP3K1(1), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2) 14312616 21 19 21 6 9 4 4 4 0 0 0.354 0.999 1.000 379 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(2), HRAS(2), IRS1(2), JAK2(2), MAPK1(1), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1) 11586731 20 16 20 6 8 7 2 2 1 0 0.460 0.999 1.000 380 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), ELTD1(1), EMR2(4), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(2), LPHN3(6), SCTR(1), VIPR1(1) 10044219 22 21 21 9 7 4 3 4 4 0 0.715 0.999 1.000 381 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(1), GOT1(1), ME1(1), ME3(1), PGK2(1), TKT(1), TKTL1(1), TPI1(1) 7579616 8 8 8 4 2 3 1 2 0 0 0.790 0.999 1.000 382 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACPT(2), ALPI(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A7(1), DHRS1(2), DHRS7(1), DHRSX(1), PON1(1), PON2(1) 6779171 15 12 15 7 5 2 4 1 3 0 0.702 0.999 1.000 383 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAD(1), BCL2A1(1), CASP1(4), CASP7(1), DAXX(1), DFFA(1), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NTRK1(3), PTPN13(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(2) 16377195 25 20 25 5 5 15 4 1 0 0 0.136 0.999 1.000 384 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GRM1(4), GRM3(1), GRM4(2), GRM5(2), GRM7(1), GRM8(1) 7861781 13 13 12 6 8 2 1 0 2 0 0.606 0.999 1.000 385 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH5A1(1), EHHADH(3), GAD2(4), PDHA2(1) 9688531 17 17 16 7 5 7 2 1 2 0 0.624 0.999 1.000 386 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(1), H6PD(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(1), RBKS(2), TKT(1) 7686173 12 12 12 5 3 1 3 3 2 0 0.841 0.999 1.000 387 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), EPRS(2), GARS(1), HARS(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(2), QARS(2), TARS(1), WARS(1) 11975625 17 14 17 5 5 5 3 1 3 0 0.589 0.999 1.000 388 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 IL6(1), JAK1(2), JAK2(2), JAK3(2), PIAS3(2), PTPRU(3) 5157881 12 10 12 5 6 4 2 0 0 0 0.676 0.999 1.000 389 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), DDC(1), EPX(1), ESCO1(5), GOT1(1), HPD(1), LPO(1), TPO(1) 12800775 15 14 15 6 5 3 1 1 5 0 0.756 0.999 1.000 390 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPT(2), ALPI(1), ALPP(2), ALPPL2(1), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP3A7(1), CYP4F8(1), PON1(1) 11016535 22 20 22 8 11 2 6 1 2 0 0.590 0.999 1.000 391 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(1), HRAS(2), KLK2(1), PIK3R1(2), PLCG1(1), RAF1(1), SHC1(2), SOS1(1) 6315342 11 10 11 5 6 2 2 0 1 0 0.759 0.999 1.000 392 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(2), CREBBP(5), DVL1(1), EP300(4), FZD1(2), GSK3B(1), LEF1(1), PITX2(1), TRRAP(2) 11873887 19 18 19 7 8 4 2 1 4 0 0.569 0.999 1.000 393 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 GSTA2(1), GSTM3(1), GSTM4(2), OPLAH(2) 7984839 6 5 6 2 2 2 0 1 1 0 0.622 0.999 1.000 394 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT2(1), BPNT1(3), MAPK1(1), PDK1(1), PIK3CD(1), RBL2(1), SHC1(2), SOS1(1) 6533715 12 12 12 5 6 4 1 0 1 0 0.675 0.999 1.000 395 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), PYCR1(1) 6596731 7 7 7 8 2 2 1 1 1 0 0.993 1.000 1.000 396 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), ETV3(3), HDAC5(2), HRAS(2), NCOR2(1), RBL1(2), RBL2(1), SIN3B(1) 9817724 13 11 13 6 3 2 3 0 5 0 0.828 1.000 1.000 397 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(1), ACADSB(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(3), GAD2(4) 10901478 22 19 22 8 5 10 4 1 2 0 0.529 1.000 1.000 398 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(2), CYP4F2(1), EPX(1), LPO(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PTGS1(1), PTGS2(3), TPO(1) 10512331 15 14 15 5 4 8 2 1 0 0 0.474 1.000 1.000 399 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CYP2C19(1), DHRS1(2), DHRS7(1), DHRSX(1), EHHADH(3), ESCO1(5) 11581488 18 13 17 6 5 5 3 1 4 0 0.543 1.000 1.000 400 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), AKT2(1), BCR(1), BTK(1), CDKN2A(1), ITPR1(2), ITPR2(3), ITPR3(1), PDK1(1), PITX2(1), PLCG2(1), PPP1R13B(1), PTPRC(3), RPS6KA1(1), SYK(2), VAV1(2) 19680027 23 23 23 6 6 5 3 2 7 0 0.468 1.000 1.000 401 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PLCG1(1), PRKCA(1), SYT1(1) 5163384 3 3 3 2 2 0 0 1 0 0 0.853 1.000 1.000 402 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), DAO(2), GARS(1), GCAT(1), GLDC(2), PLCG1(1), PLCG2(1), SARDH(2), SHMT1(3), SHMT2(1), TARS(1) 15774209 22 19 22 9 7 5 2 1 7 0 0.808 1.000 1.000 403 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), DDC(1), EPX(1), GOT1(1), HPD(1), LPO(1), TPO(1) 8238325 10 9 10 6 4 3 1 0 2 0 0.886 1.000 1.000 404 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 IRAK1(1), MAP2K4(1), MAP3K1(1), MAP3K7(2), NFKB1(2), PPARA(2), RELA(1), TLR10(1), TLR7(1), TLR9(1) 13657130 13 9 13 3 7 4 0 1 1 0 0.320 1.000 1.000 405 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(3), CANT1(1), CTPS2(1), DHODH(1), DPYD(3), DPYS(1), ENTPD6(1), ENTPD8(1), NT5C2(2), NT5M(1), PNPT1(1), POLA1(1), POLD3(1), POLE(4), POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1), RRM1(2), RRM2B(1), TXNRD1(1), UCK2(1), UPP1(2) 30377669 41 30 41 8 13 15 4 2 7 0 0.0483 1.000 1.000 406 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1RAP(2), IL6(1), IRAK1(1), IRAK2(1), MAP3K1(1), MAP3K7(2), NFKB1(2), RELA(1), TGFB1(1), TGFB2(1), TNF(1) 11128489 14 12 14 5 5 6 1 0 2 0 0.569 1.000 1.000 407 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), HEXB(1), LCT(3), NEU1(1) 7698374 6 5 6 5 2 2 1 0 1 0 0.953 1.000 1.000 408 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(1), H6PD(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(1), RBKS(2), TKT(1), TKTL1(1) 9145868 13 13 13 5 4 1 3 3 2 0 0.785 1.000 1.000 409 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CSK(1), DAG1(2), EPHB2(3), ITK(1), ITPKB(2), LCP2(1), MAPK1(1), NFKB1(2), PAK2(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RAF1(1), SOS1(1), VAV1(2), ZAP70(1) 21022186 26 21 26 6 10 10 2 3 1 0 0.210 1.000 1.000 410 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX15(2), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP4F2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PTGS1(1), PTGS2(3) 14648515 18 17 18 5 5 6 5 1 1 0 0.377 1.000 1.000 411 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 GSTA2(1), GSTM3(1), GSTM4(2) 6476237 4 3 4 2 1 2 0 1 0 0 0.823 1.000 1.000 412 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), MAP2K4(1), MAP3K1(1), MAPK1(1), NFKB1(2), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), TRAF2(2) 7721023 12 9 12 5 1 8 2 1 0 0 0.728 1.000 1.000 413 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BTK(1), CAD(3), DAXX(1), DEDD2(1), DFFA(1), EGFR(3), EPHB2(3), FAF1(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MET(1), NFKB1(2), PFN2(2), PTPN13(2), RALBP1(1), RIPK1(1), ROCK1(4), TNFRSF6B(1), TPX2(1), TRAF2(2) 27075151 40 30 40 9 13 12 5 3 7 0 0.173 1.000 1.000 414 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(1), DHCR7(1), GGCX(1), NQO1(1), SQLE(1), TM7SF2(1) 7241099 7 7 7 6 4 1 1 0 1 0 0.974 1.000 1.000 415 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(1), AKT1(1), GNAS(2), GNB1(1), GNGT1(1), NFKB1(2), NOS3(1), NPPA(1), PIK3R1(2), RELA(1), SYT1(1) 5930349 14 12 14 6 3 9 0 1 1 0 0.798 1.000 1.000 416 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 CAMK2A(1), CAMK2D(1), CLCA2(1), CNGA3(3), CNGA4(3), GNAL(1), GUCA1A(1), PDE1C(1), PRKACA(1), PRKX(2) 11447446 15 14 15 7 5 2 4 1 3 0 0.725 1.000 1.000 417 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG12(1), ALG14(1), B4GALT1(2), B4GALT2(2), DOLPP1(1), FUT8(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT1(1), MGAT5(1), MGAT5B(3), RPN1(1), ST6GAL1(1) 15894462 20 17 20 5 10 5 1 0 4 0 0.320 1.000 1.000 418 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(3), GAD2(4) 10141857 19 17 18 8 6 9 3 0 1 0 0.620 1.000 1.000 419 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF2(1), EEF2K(3), EIF2AK3(3), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4G1(2), EIF4G3(2), EIF5B(1), KIAA0664(1) 16464667 18 17 18 6 5 1 2 4 6 0 0.729 1.000 1.000 420 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(3), CANT1(1), CTPS2(1), DHODH(1), DPYD(3), DPYS(1), NT5M(1), POLE(4), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), RRM1(2), TXNRD1(1), UCK2(1), UPP1(2) 21559922 29 22 29 7 11 7 4 3 4 0 0.174 1.000 1.000 421 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLD3(1), POLE(4), POLG(1), POLL(1), POLM(1), POLQ(3), REV1(1), REV3L(2) 15171314 15 13 15 8 3 3 2 2 5 0 0.963 1.000 1.000 422 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(1), RPS6KA1(1) 7730668 14 14 14 8 2 5 3 3 1 0 0.945 1.000 1.000 423 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(5), EP300(4), PRKAR1A(1), PRKAR1B(1) 7764412 11 10 11 8 4 2 2 2 1 0 0.964 1.000 1.000 424 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), DFFA(1), LMNA(1), MADD(2), MAP2K4(1), MAP3K1(1), MAP3K7(2), PAK2(1), PRKDC(8), RB1(3), RIPK1(1), SPTAN1(1), TNF(1), TRAF2(2) 14548244 26 20 26 8 10 9 2 2 2 1 0.441 1.000 1.000 425 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(1), AKT2(1), BRD4(2), CAP1(1), CBL(1), CDKN2A(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), PDK1(1), PIK3CD(1), PIK3R1(2), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(2), SOS1(1), YWHAQ(1) 21313589 31 27 31 8 12 6 2 3 8 0 0.346 1.000 1.000 426 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(2), ANXA4(1), HSD11B1(1), PLA2G4A(2), PTGER2(1), PTGS1(1), PTGS2(3), SCGB1A1(1) 7746933 12 12 12 6 3 4 4 0 1 0 0.829 1.000 1.000 427 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(5), EP300(4), ERCC3(3), ESR1(1), GRIP1(3), GTF2A1(1), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(1), NRIP1(1), PELP1(1), POLR2A(2) 17299830 30 21 29 8 13 7 3 2 5 0 0.241 1.000 1.000 428 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPNS1(1), EGFR(3), HRAS(2), MAPK1(1), MYL2(1), MYLK(4), PRKAR1A(1), PRKAR1B(1), PTK2(2), PXN(1), TLN1(2) 12278448 19 18 19 7 6 6 4 2 1 0 0.564 1.000 1.000 429 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(1), BAD(1), CBL(1), HRAS(2), IRS1(2), JAK1(2), JAK3(2), MAPK1(1), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1), SYK(2) 12757807 22 20 22 8 10 7 3 1 1 0 0.604 1.000 1.000 430 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(1), EIF2B2(1), EIF2B3(1), FLT1(1), FLT4(2), HRAS(2), KDR(5), NOS3(1), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(2), PXN(1), SHC1(2), VHL(1) 11948079 24 16 24 7 13 5 1 1 4 0 0.415 1.000 1.000 431 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), HRAS(2), JAK2(2), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT5A(1), STAT5B(1) 9811359 16 12 16 6 7 5 3 1 0 0 0.615 1.000 1.000 432 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ACOX3(1), ACSL1(1), ACSL4(1), ACSL6(2), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CPT1C(2), EHHADH(3), HADHB(1) 18367655 25 17 23 6 10 7 6 0 2 0 0.206 1.000 1.000 433 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(1), HRAS(2), IGF1R(2), IRS1(2), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1) 8447779 13 11 13 6 5 3 3 1 1 0 0.808 1.000 1.000 434 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(5), EP300(4), IL7R(1), JAK1(2), JAK3(2), PIK3R1(2), STAT5A(1), STAT5B(1) 9673085 18 17 18 7 7 7 2 1 1 0 0.698 1.000 1.000 435 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(1), BCR(1), HRAS(2), JAK2(2), MAP2K4(1), MAP3K1(1), PIK3R1(2), RAF1(1), SOS1(1), STAT1(1), STAT5A(1), STAT5B(1) 9731841 15 13 15 6 4 6 4 1 0 0 0.661 1.000 1.000 436 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(1), INPP5D(2), JAK1(2), JAK2(2), JAK3(2), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(1), TYK2(1) 13057320 20 18 20 9 7 7 3 0 3 0 0.768 1.000 1.000 437 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH6(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DGAT1(1), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), GK(1), LCT(3), LIPG(3), PNLIP(1), PNLIPRP1(1), PPAP2B(1) 18145380 31 25 31 9 10 9 3 4 5 0 0.339 1.000 1.000 438 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), MAP3K1(1), NFATC1(2), NFATC2(1), NFKB1(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RELA(1), SYT1(1) 10499173 14 12 14 6 3 5 2 3 1 0 0.732 1.000 1.000 439 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(2), B4GALT2(2), GAA(2), GALK1(1), GANAB(1), GCK(1), HK2(1), HK3(2), LCT(3), MGAM(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 12267561 20 17 20 9 9 4 2 2 3 0 0.738 1.000 1.000 440 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB3(1), EEF2K(3), MAP2K4(1), MAP3K10(4), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPKAPK5(1), NFKB1(2) 12539160 17 13 17 8 7 4 1 2 3 0 0.846 1.000 1.000 441 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(1), HRAS(2), IRS1(2), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1) 8719582 11 10 11 7 5 2 2 1 1 0 0.931 1.000 1.000 442 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(4), ACACB(3), ACAT1(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), EHHADH(3), MUT(1), SUCLG1(1) 14887839 18 15 17 6 7 6 3 1 1 0 0.486 1.000 1.000 443 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DLAT(1), ME1(1), ME3(1), PC(1), PDHA2(1) 13876266 15 15 15 5 2 7 2 2 2 0 0.535 1.000 1.000 444 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACO2(1), FH(1), PC(1), PCK2(2), SUCLG1(1) 10851084 6 5 6 5 1 0 2 1 2 0 0.936 1.000 1.000 445 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP5A1(2), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), CYC1(1), NDUFA10(2), NDUFB10(1), NDUFB7(1), NDUFB9(1), NDUFS3(1), NDUFV1(1), UQCRC1(1), UQCRFS1(1) 20981873 28 24 28 8 5 10 7 2 4 0 0.494 1.000 1.000 446 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), EGFR(3), HRAS(2), JAK1(2), MAP2K4(1), MAP3K1(1), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT5A(1) 12598696 20 18 20 8 6 8 4 2 0 0 0.699 1.000 1.000 447 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(1), GALNT4(1), GALNTL2(1), GALNTL5(3), OGT(1), ST3GAL1(1), WBSCR17(2) 12077253 15 13 15 8 5 2 3 3 2 0 0.922 1.000 1.000 448 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(1), AKT2(1), BAD(1), CDKN1B(4), CDKN2A(1), CREB3(1), ERBB4(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(2), IRS2(2), IRS4(3), MET(1), PAK2(1), PAK6(1), PAK7(1), PDK1(1), PIK3CD(1), PPP1R13B(1), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC2(2), YWHAQ(1) 27962970 37 30 37 9 9 10 1 3 14 0 0.438 1.000 1.000 449 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), MCM10(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), POLD3(1), POLE(4), RFC3(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1) 18963565 26 19 26 7 7 10 4 1 4 0 0.324 1.000 1.000 450 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F5(5), F8(2), FGA(2), KLKB1(1), PROS1(2) 16591849 22 20 22 8 6 11 2 2 1 0 0.675 1.000 1.000 451 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN3(1), DMD(4), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH6(4), MYH7(4), MYH8(3), MYL1(1), MYL2(1), MYOM1(2), NEB(5), TCAP(2), TNNT2(1), TPM1(1), TTN(46) 50666427 83 61 83 14 31 15 17 5 14 1 0.00986 1.000 1.000 452 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(3), ACAT1(1), ACOT12(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), DLAT(1), ME1(1), ME3(1), PC(1), PCK2(2), PDHA2(1) 17563180 21 19 20 7 8 6 3 2 2 0 0.436 1.000 1.000 453 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), ARHGDIB(1), BIRC2(1), CASP7(1), DAXX(1), DFFA(1), GSN(2), LMNA(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MDM2(1), NFKB1(2), PAK2(1), PRKDC(8), PSEN1(1), PTK2(2), RB1(3), RELA(1), RIPK1(1), SPTAN1(1), TNF(1), TRAF1(1), TRAF2(2) 25974757 38 24 38 8 12 16 3 2 4 1 0.107 1.000 1.000 454 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(1), ACVR1C(1), ACVRL1(1), BMP5(2), BMP6(1), BMP7(3), BMPR2(1), CHRD(1), COMP(1), CREBBP(5), EP300(4), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(1), LTBP1(3), MAPK1(1), PITX2(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), RBL1(2), RBL2(1), ROCK1(4), ROCK2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SP1(1), TGFB1(1), TGFB2(1), TGFBR1(2), THBS1(4), THBS3(1), THBS4(1), TNF(1), ZFYVE16(1), ZFYVE9(1) 37291297 68 52 68 15 19 19 13 10 7 0 0.0906 1.000 1.000 455 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(3), F2(1), F2RL3(1), MAPK1(1), PLD1(2), PTK2(2), RAF1(1), RASAL1(2), VAV1(2) 10319616 17 14 17 8 9 5 1 1 1 0 0.764 1.000 1.000 456 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(1), ALDOC(1), FUK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKFB4(1), PFKM(1), PFKP(1), PGM2(2), PMM1(1), RDH12(1), TPI1(1), TSTA3(2) 14006127 18 16 18 6 5 6 3 2 2 0 0.460 1.000 1.000 457 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), CACNA1A(9), GNA12(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GRIA1(4), GRIA2(3), GRIA3(1), GRID2(4), GRM1(4), GRM5(2), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), HRAS(2), IGF1R(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NOS1(2), NOS3(1), NPR2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCB1(2), PLCB4(2), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PRKCA(1), RAF1(1), RYR1(7) 40877449 82 65 81 18 36 14 9 8 15 0 0.0404 1.000 1.000 458 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(1), DLAT(1), ENO1(2), GCK(1), GOT1(1), HK2(1), HK3(2), PC(1), PDHA2(1), PDHX(1), PFKM(1), PFKP(1), PGK2(1), TPI1(1) 15954776 16 16 16 8 4 5 2 1 4 0 0.782 1.000 1.000 459 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(1), AKT2(1), ASAH1(2), DAG1(2), EGFR(3), EPHB2(3), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), PIK3CB(2), PITX2(1), PLCB1(2), PLCB4(2), RAF1(1), RGS20(1), SHC1(2), SOS1(1), TERF2IP(1) 20823978 36 34 36 10 15 12 2 0 7 0 0.295 1.000 1.000 460 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), HRAS(2), MAP2K4(1), MAP3K1(1), MAPK1(1), PLCG1(1), PRKCA(1), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 10685284 14 11 14 6 6 2 3 2 1 0 0.784 1.000 1.000 461 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CITED2(1), CREBBP(5), EHHADH(3), EP300(4), FABP1(2), HSPA1A(1), MAPK1(1), ME1(1), NCOA1(1), NCOR1(5), NCOR2(1), NR1H3(1), NR2F1(1), NRIP1(1), PIK3R1(2), PPARA(2), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PTGS2(3), RB1(3), RELA(1), SP1(1), STAT5A(1), STAT5B(1), TNF(1) 22954223 46 33 46 12 15 16 5 3 6 1 0.178 1.000 1.000 462 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), TPI1(1) 18329997 23 21 23 8 5 7 3 4 4 0 0.593 1.000 1.000 463 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), TPI1(1) 18329997 23 21 23 8 5 7 3 4 4 0 0.593 1.000 1.000 464 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 HRAS(2), MAP2K4(1), MAP3K1(1), NFATC1(2), NFATC2(1), NFKB1(2), PIK3R1(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RAF1(1), RELA(1), SHC1(2), SOS1(1), SYT1(1), VAV1(2), ZAP70(1) 17091467 25 20 25 9 9 7 4 5 0 0 0.564 1.000 1.000 465 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), HRAS(2), JAK1(2), MAP2K4(1), MAP3K1(1), PDGFRA(3), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT5A(1) 11637761 20 17 20 9 8 5 4 2 1 0 0.808 1.000 1.000 466 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(1), AKT2(1), DDIT4(1), MAPK1(1), PDPK1(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRKAA2(3), RPS6KA1(1), RPS6KA6(1), TSC2(2), ULK3(1), VEGFA(2) 18636309 26 22 26 9 12 5 2 2 5 0 0.567 1.000 1.000 467 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 APOA4(1), CETP(1), CYP7A1(3), DGAT1(1), LDLR(1), LRP1(3), SCARB1(2) 10280384 12 12 12 7 5 4 1 1 1 0 0.871 1.000 1.000 468 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(2), ASAH1(2), B4GALT6(1), CERK(1), DEGS2(2), LCT(3), NEU1(1), PPAP2B(1), SGMS1(2), SMPD4(1) 13470895 16 12 16 7 7 4 3 0 2 0 0.608 1.000 1.000 469 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CHAT(3), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), ETNK1(1), GNPAT(1), PAFAH2(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PPAP2B(1) 18809943 26 23 26 8 8 4 6 4 4 0 0.481 1.000 1.000 470 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), GALNS(2), HEXB(1), LCT(3), NEU1(1), SPAM1(1) 13002685 10 9 10 6 4 3 2 0 1 0 0.880 1.000 1.000 471 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(3), ANAPC1(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), BUB1(1), BUB1B(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(1), CDC25A(1), CDC25B(1), CDC27(1), CDC6(2), CDC7(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CHEK2(1), CREBBP(5), E2F3(1), EP300(4), ESPL1(1), FZR1(3), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), PLK1(2), PRKDC(8), RB1(3), RBL1(2), RBL2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMC1B(1), TGFB1(1), TGFB2(1), YWHAQ(1) 48269582 84 55 84 16 25 22 14 6 16 1 0.0274 1.000 1.000 472 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(1), AKT2(1), BTK(1), FCER1A(1), GAB2(5), HRAS(2), IL4(1), INPP5D(2), LCP2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), PDK1(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PRKCA(1), RAC1(1), RAC2(2), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(2), VAV2(1), VAV3(4) 26319768 54 46 53 15 21 11 9 5 8 0 0.282 1.000 1.000 473 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1B(1), ADH6(1), AKR1C3(1), AKR1C4(1), ALDH1A3(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP2S1(1), CYP3A7(1), EPHX1(1), GSTA2(1), GSTM3(1), GSTM4(2), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1) 21490238 37 30 37 10 9 12 6 5 5 0 0.340 1.000 1.000 474 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BIRC2(1), CASP7(1), FASLG(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MCL1(1), MDM2(1), NFKB1(2), PARP1(2), RELA(1), RIPK1(1), TNF(1), TRAF1(1), TRAF2(2) 13754371 19 15 19 8 2 11 2 2 2 0 0.740 1.000 1.000 475 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), DOT1L(2), EHMT2(1), EZH1(1), EZH2(1), JMJD4(1), KDM6A(6), MEN1(1), MLL(2), MLL2(13), MLL3(10), MLL5(1), NSD1(1), OGT(1), PAXIP1(2), PPP1CA(1), PRDM9(2), PRMT1(1), PRMT5(1), RBBP5(2), SETD1A(3), SETD2(6), SETDB1(2), STK38(1), SUV420H2(1), WHSC1(1), WHSC1L1(3) 44583150 71 53 71 16 17 14 7 7 25 1 0.338 1.000 1.000 476 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACOX3(1), ACSL1(1), ACSL4(1), ACSL6(2), CPT1C(2), CYP7A1(3), EHHADH(3), FABP1(2), FABP2(1), FABP4(1), FADS2(2), GK(1), HMGCS2(1), ME1(1), NR1H3(1), PCK2(2), PDPK1(1), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRB(1), RXRG(1), SCD(1), SLC27A1(1), SLC27A4(1), SLC27A6(1), SORBS1(2), UBC(1) 24569663 43 31 43 11 14 14 7 3 5 0 0.211 1.000 1.000 477 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP4A(1), INPPL1(1), ITPKB(2), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3CB(2), PIK3CG(3), PLCB1(2), PLCB4(2), PLCG1(1), PLCG2(1) 15984139 21 16 21 8 9 7 3 0 2 0 0.550 1.000 1.000 478 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E2(1), GTF2I(1), GTF2IRD1(1), TAF1L(3), TAF4(1), TAF5(1), TAF7L(2) 13466026 11 9 11 7 3 5 1 1 1 0 0.965 1.000 1.000 479 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(1), ASAH1(2), CREB3(1), CREBBP(5), DAG1(2), EGR1(1), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), NTRK1(3), OPN1LW(1), PIK3CD(1), PIK3R1(2), SHC1(2), TERF2IP(1) 17960183 31 27 31 11 14 8 1 3 5 0 0.587 1.000 1.000 480 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH6(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), DGAT1(1), DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), GK(1), GPAM(3), LCT(3), LIPG(3), MGLL(1), PNLIP(1), PNLIPRP1(1), PPAP2B(1) 22072330 40 32 39 12 13 11 3 4 9 0 0.357 1.000 1.000 481 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BAD(1), BIRC2(1), CASP1(4), CASP7(1), DFFA(1), FASLG(1), IRF2(2), IRF3(1), IRF4(3), IRF6(1), LTA(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MDM2(1), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF21(1), TRAF1(1), TRAF2(2) 21341262 32 25 32 10 5 14 4 3 6 0 0.538 1.000 1.000 482 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(1), BAI1(2), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(1), GTSE1(1), MDM2(1), MDM4(1), PPM1D(2), RCHY1(1), RRM2B(1), SERPINB5(1), SESN1(1), SESN2(1), SESN3(3), THBS1(4), TNFRSF10B(1), TSC2(2) 21639312 32 25 31 10 13 3 8 0 8 0 0.402 1.000 1.000 483 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(1), CAPN11(2), CAPN3(1), CAPNS1(1), CAV3(1), CRK(1), CSK(1), GIT2(2), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAD(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGAX(1), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), MAPK10(1), MYLK2(2), PAK2(1), PAK6(1), PDPK1(1), PIK3R2(2), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAPGEF1(3), ROCK1(4), ROCK2(1), SHC1(2), SHC3(1), SORBS1(2), SOS1(1), TLN1(2), TNS1(6), VAV2(1), VAV3(4) 50465141 82 59 81 20 27 25 11 9 10 0 0.0840 1.000 1.000 484 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CREB3(1), CREB3L3(1), E2F3(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), MYT1(1), POLE(4), RB1(3), RBL1(2), RPA1(1), RPA2(1), TFDP2(1), TNXB(7) 26354952 45 29 45 15 16 11 5 4 8 1 0.569 1.000 1.000 485 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(2), GAA(2), GANAB(1), GBE1(2), GCK(1), HK2(1), HK3(2), MGAM(1), PGM1(1), PGM3(1), PYGL(2), UGDH(1), UGT1A1(3), UGT2B15(2) 21350908 30 29 30 10 7 9 5 2 7 0 0.617 1.000 1.000 486 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(1), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(5), EP300(4), GRIA1(4), GRIA2(3), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRM1(4), GRM5(2), HRAS(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PLCB1(2), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), RPS6KA1(1), RPS6KA6(1) 36810277 69 58 68 21 24 18 5 9 13 0 0.364 1.000 1.000 487 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(1), BMP7(3), BMPR2(1), CCL28(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CD27(1), CNTF(2), CSF1R(1), CSF2RA(2), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EDA(1), EGFR(3), FASLG(1), FLT1(1), FLT3(1), FLT4(2), GH2(1), GHR(2), HGF(2), IFNA10(1), IFNA13(1), IFNW1(1), IL10RA(3), IL11RA(1), IL12RB2(4), IL13RA1(1), IL17A(1), IL17RA(3), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL23A(1), IL25(1), IL28A(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(1), IL9(1), INHBA(2), INHBC(1), KDR(5), LEPR(1), LIF(1), LIFR(2), LTA(1), LTBR(3), MET(1), PDGFRA(3), PDGFRB(1), PF4(1), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(2), TNFRSF13B(3), TNFRSF18(1), TNFRSF19(1), TNFRSF21(1), TNFRSF4(2), TNFRSF6B(1), TNFSF11(1), TNFSF14(1), TNFSF8(1), TPO(1), VEGFA(2), XCL1(1), XCR1(1) 66622196 117 69 117 28 31 43 19 7 17 0 0.0242 1.000 1.000 488 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(1), INPP4A(1), INPP5B(2), INPP5E(1), INPPL1(1), IPMK(1), ITPK1(2), ITPKB(2), OCRL(2), PI4KA(1), PI4KB(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIP5K1C(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), SYNJ1(2), SYNJ2(2) 26823069 38 31 38 11 12 12 6 5 3 0 0.288 1.000 1.000 489 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(5), DLL3(3), DLL4(1), DTX1(2), DTX2(1), DTX4(1), DVL1(1), DVL2(2), DVL3(1), EP300(4), JAG2(3), MAML1(1), MAML2(1), MAML3(1), NCOR2(1), NOTCH1(2), NOTCH2(3), NOTCH3(3), NOTCH4(2), NUMB(1), NUMBL(1), PSEN1(1), RBPJL(1), SNW1(2) 26345507 44 35 44 13 13 10 8 2 11 0 0.428 1.000 1.000 490 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CXCR6(1), FPR1(1), FSHR(1), GNRHR(3), LHCGR(1), MC4R(1), NPY1R(1), NPY2R(1), SSTR1(1), SSTR2(1), SSTR3(1), TACR1(1), TACR3(1), TRHR(1), TSHR(1) 19623854 31 27 31 12 9 9 3 4 6 0 0.547 1.000 1.000 491 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(1), AKT2(1), BAD(1), HRAS(2), KDR(5), MAPK1(1), MAPKAPK3(1), NFATC1(2), NFATC2(1), NOS3(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(1), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), SH2D2A(2), SHC2(1), VEGFA(2) 26354702 53 37 53 15 19 13 9 4 8 0 0.234 1.000 1.000 492 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(1), AKT2(1), BTK(1), CARD11(1), CD81(1), FCGR2B(1), GSK3B(1), HRAS(2), INPP5D(2), LILRB3(1), NFATC1(2), NFATC2(1), NFKB1(2), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(2), SYK(2), VAV1(2), VAV2(1), VAV3(4) 27189770 44 36 43 16 18 8 7 4 7 0 0.515 1.000 1.000 493 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(3), ABL2(1), AKT1(1), AKT2(1), ARAF(1), BAD(1), CAMK2A(1), CAMK2D(1), CBL(1), CDKN1A(2), CDKN1B(4), CRK(1), EGFR(3), ERBB2(1), ERBB3(4), ERBB4(1), GSK3B(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), NRG1(1), NRG2(1), NRG3(2), PAK2(1), PAK6(1), PAK7(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(1), PTK2(2), RAF1(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), STAT5A(1), STAT5B(1) 37301534 65 44 65 19 22 17 7 3 16 0 0.302 1.000 1.000 494 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTG1(1), ACTN3(1), ACVR1B(1), ACVR1C(1), CDH1(3), CREBBP(5), CSNK2A1(1), CSNK2A2(1), CTNNA2(4), CTNNA3(1), EGFR(3), EP300(4), ERBB2(1), IGF1R(2), IQGAP1(3), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(1), MET(1), MLLT4(2), NLK(1), PTPN1(1), PTPRB(3), PTPRF(1), PVRL1(1), RAC1(1), RAC2(2), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(2), TJP1(4), WASF2(1), WASF3(1) 44314189 71 54 71 21 21 18 10 11 11 0 0.358 1.000 1.000 495 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BAD(1), CABIN1(2), CAMK4(2), CD69(1), CDKN1A(2), CEBPB(1), CNR1(1), CREBBP(5), CSNK2A1(1), EGR3(1), EP300(4), FCER1A(1), FCGR3A(1), GSK3A(1), GSK3B(1), HRAS(2), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(1), MEF2D(2), NFATC1(2), NFATC2(1), NPPB(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(1), SP1(1), SP3(2), TGFB1(1), TNF(1), TRAF2(2), VAV1(2), VAV2(1), VAV3(4), XPO5(1) 34233584 60 48 59 21 21 17 7 5 10 0 0.526 1.000 1.000 496 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AKT1(1), AKT2(1), APAF1(1), BAD(1), BIRC2(1), CASP7(1), DFFA(1), ENDOG(1), FASLG(1), IL1RAP(2), IL3RA(2), IRAK1(1), IRAK2(1), IRAK4(1), NFKB1(2), NTRK1(3), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), RELA(1), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(2) 27968872 45 35 45 15 11 18 7 4 5 0 0.431 1.000 1.000 497 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(1), AKT2(1), CBL(1), CCND3(1), CNTF(2), CREBBP(5), CSF2RA(2), CSF3R(1), EP300(4), GH2(1), GHR(2), IFNA10(1), IFNA13(1), IFNW1(1), IL10RA(3), IL11RA(1), IL12RB2(4), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL23A(1), IL28A(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(1), IL9(1), JAK1(2), JAK2(2), JAK3(2), LEPR(1), LIF(1), LIFR(2), PIAS3(2), PIAS4(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), SOCS5(1), SOS1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT4(3), STAT5A(1), STAT5B(1), STAT6(1), TPO(1), TYK2(1) 53153339 85 59 85 25 23 31 15 3 13 0 0.263 1.000 1.000 498 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG12(1), ALG14(1), B3GNT1(1), B3GNT7(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), B4GALT7(1), CHPF(1), CHST11(1), CHST4(1), CHSY1(1), EXT1(1), EXT2(2), EXTL1(3), EXTL3(2), FUT8(1), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(1), GALNT4(1), GALNTL2(1), GALNTL5(3), GANAB(1), HS2ST1(1), HS3ST2(1), HS6ST1(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT1(1), MGAT5(1), MGAT5B(3), NDST1(3), NDST2(1), NDST4(4), OGT(1), RPN1(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(2), XYLT1(4) 41374662 66 47 66 19 24 19 9 6 8 0 0.256 1.000 1.000 499 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(3), ACSL1(1), ACSL4(1), ACSL6(2), ADIPOR1(1), ADIPOR2(1), AKT1(1), AKT2(1), CPT1C(2), IRS1(2), IRS2(2), IRS4(3), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MAPK10(1), NFKB1(2), PCK2(2), POMC(1), PPARA(2), PPARGC1A(2), PRKAA2(3), PRKAG1(2), PRKAG2(1), PRKAG3(1), RELA(1), RXRB(1), RXRG(1), TNF(1), TRAF2(2), TYK2(1) 30684057 51 36 51 18 19 16 5 4 7 0 0.496 1.000 1.000 500 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CHRM3(1), CHRM4(1), CNR1(1), CYSLTR2(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR2(1), GABRA3(1), GABRB1(3), GABRB2(1), GABRD(1), GABRE(2), GABRG1(4), GABRR2(2), GH2(1), GHR(2), GLP2R(2), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(2), GPR83(2), GRIA1(4), GRIA2(3), GRIA3(1), GRIA4(1), GRID1(2), GRID2(4), GRIK1(1), GRIK2(1), GRIK3(2), GRIK4(3), GRIK5(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRIN3A(1), GRIN3B(2), GRM1(4), GRM3(1), GRM4(2), GRM5(2), GRM7(1), GRM8(1), GZMA(1), HCRTR2(3), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), LEPR(1), LHCGR(1), MAS1(1), MC4R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), P2RX5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PTGER2(1), PTH2R(2), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR5(1), TAAR1(1), TAAR5(1), TAAR6(1), TAAR9(1), TACR1(1), TACR3(1), TBXA2R(2), THRA(2), TRHR(1), TSHR(1), VIPR1(1) 83349599 179 117 176 56 83 40 14 18 24 0 0.0332 1.000 1.000 501 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY4(2), ADCY7(1), ADCY8(4), ADCY9(2), ADORA2A(1), ADRA1A(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(3), ATP2B3(2), ATP2B4(3), AVPR1B(1), BDKRB1(1), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(2), CACNA1S(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(3), CCKBR(1), CD38(1), CHRM3(1), CYSLTR2(1), EGFR(3), ERBB2(1), ERBB3(4), ERBB4(1), GNAL(1), GNAS(2), GRIN1(1), GRIN2A(6), GRIN2C(1), GRM1(4), GRM5(2), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), LHCGR(1), MYLK(4), MYLK2(2), NOS1(2), NOS3(1), P2RX5(2), PDE1B(1), PDE1C(1), PDGFRA(3), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKCA(1), PRKX(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(2), TACR1(1), TACR3(1), TBXA2R(2), TRHR(1), VDAC1(1) 101276069 187 115 186 85 76 42 13 17 39 0 0.944 1.000 1.000 502 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTG1(1), ACTN3(1), AKT1(1), AKT2(1), BAD(1), BCAR1(1), BIRC2(1), CAV3(1), CCND3(1), COL11A1(6), COL11A2(5), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), CRK(1), DIAPH1(1), EGFR(3), ERBB2(1), FLNB(1), FLNC(2), FLT1(1), FN1(2), GSK3B(1), HGF(2), HRAS(2), IGF1R(2), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), KDR(5), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MET(1), MYL2(1), MYL5(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PARVB(1), PARVG(2), PDGFRA(3), PDGFRB(1), PDPK1(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PRKCA(1), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), RAPGEF1(3), RELN(3), ROCK1(4), ROCK2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), THBS1(4), THBS3(1), THBS4(1), TLN1(2), TLN2(2), TNC(3), TNN(1), TNR(1), TNXB(7), VAV1(2), VAV2(1), VAV3(4), VEGFA(2), VWF(7) 137306147 220 115 219 79 80 65 22 18 35 0 0.417 1.000 1.000 503 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ACTN3(1), APC(2), APC2(1), ARAF(1), ARHGEF1(3), ARHGEF6(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(1), CFL1(1), CFL2(1), CHRM3(1), CHRM4(1), CRK(1), CSK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), EGFR(3), F2(1), FGD1(1), FGD3(1), FGF10(2), FGF13(1), FGF16(1), FGF23(2), FGF3(1), FGF5(1), FGF9(3), FGFR2(3), FGFR3(1), FN1(2), GNA12(1), GSN(2), HRAS(2), IQGAP1(3), IQGAP2(1), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAD(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGAX(1), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), LIMK1(1), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(4), MYH9(2), MYL2(1), MYL5(1), MYLK(4), MYLK2(2), NCKAP1L(2), PAK2(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(1), PFN2(2), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), ROCK1(4), ROCK2(1), RRAS2(1), SOS1(1), SSH2(6), SSH3(2), TIAM1(3), TIAM2(2), VAV1(2), VAV2(1), VAV3(4), WASF2(1) 102593586 171 106 170 37 59 43 22 20 27 0 0.00468 1.000 1.000 504 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(1), COL11A1(6), COL11A2(5), COL17A1(1), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(3), FN1(2), GJA1(1), GJA4(1), GJA5(2), GJA8(3), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT14(1), KRT15(2), KRT16(1), KRT18(1), KRT23(2), KRT24(1), KRT25(3), KRT27(1), KRT31(1), KRT33A(1), KRT38(2), KRT39(1), KRT4(1), KRT6A(1), KRT6C(3), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(3), KRT79(1), KRT82(1), KRT83(2), KRT84(1), KRT85(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), LMNA(1), NES(3), RELN(3), THBS1(4), THBS3(1), THBS4(1), TNC(3), TNN(1), TNR(1), TNXB(7), VWF(7) 93616894 159 96 159 55 73 41 13 11 21 0 0.278 1.000 1.000 505 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(1), ACVR1C(1), AKT1(1), AKT2(1), ATF2(1), ATF4(1), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(2), CACNA1S(2), CACNA2D3(1), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNB4(1), CACNG3(1), CACNG4(1), CACNG7(2), CACNG8(1), CDC25B(1), CRK(1), DAXX(1), DUSP16(1), DUSP7(1), DUSP8(2), EGFR(3), FASLG(1), FGF10(2), FGF13(1), FGF16(1), FGF23(2), FGF3(1), FGF5(1), FGF9(3), FGFR2(3), FGFR3(1), FLNB(1), FLNC(2), GNA12(1), HRAS(2), JUND(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), NF1(1), NFATC2(1), NFKB1(2), NLK(1), NTRK1(3), PAK2(1), PDGFRA(3), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKCA(1), PRKX(2), PTPN5(2), RAC1(1), RAC2(2), RAF1(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TRAF2(2) 106786002 163 94 163 53 59 35 29 13 27 0 0.362 1.000 1.000 506 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ADRA1A(1), ADRA1D(1), ADRB1(1), ADRB2(1), ATP2A2(1), ATP2B1(1), ATP2B2(3), ATP2B3(2), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1S(2), CACNB1(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM3(1), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB5(1), GNAI2(1), GNAO1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(2), GNGT1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNB1(3), KCNJ5(2), MIB1(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RGS10(1), RGS11(1), RGS16(2), RGS20(1), RGS6(1), RGS7(1), RGS9(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(2), YWHAQ(1) 70583989 125 83 125 68 55 26 12 9 23 0 0.994 1.000 1.000 507 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), COL11A1(6), COL11A2(5), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), DAG1(2), FN1(2), FNDC1(2), FNDC3A(1), GP5(2), HSPG2(6), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), RELN(3), SDC3(1), SV2A(1), SV2B(1), THBS1(4), THBS3(1), THBS4(1), TNC(3), TNN(1), TNR(1), TNXB(7), VWF(7) 84502110 135 81 135 51 57 38 10 8 22 0 0.505 1.000 1.000 508 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(2), CFL1(1), CFL2(1), DCC(3), DPYSL2(1), DPYSL5(1), EFNB3(1), EPHA3(3), EPHA4(1), EPHA5(1), EPHA6(2), EPHA7(3), EPHB1(3), EPHB2(3), EPHB3(3), FES(2), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(2), L1CAM(3), LIMK1(1), LIMK2(3), LRRC4C(1), MAPK1(1), MET(1), NFATC1(2), NFATC2(1), NGEF(1), NTN1(1), NTNG1(4), PAK2(1), PAK6(1), PAK7(1), PLXNA1(1), PLXNB1(1), PLXNB2(1), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(2), RAC1(1), RAC2(2), RHOD(1), ROBO1(3), ROBO2(3), ROBO3(2), ROCK1(4), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4C(3), SEMA4D(1), SEMA4F(1), SEMA5A(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(1), SRGAP1(3), SRGAP3(1), UNC5A(2), UNC5B(4), UNC5D(1) 74203966 122 77 122 34 50 24 17 19 12 0 0.0970 1.000 1.000 509 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(2), APC2(1), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(5), CSNK1A1L(1), CSNK2A1(1), CSNK2A2(1), DAAM2(3), DKK2(2), DVL1(1), DVL2(2), DVL3(1), EP300(4), FBXW11(1), FZD1(2), FZD10(1), FZD2(4), FZD4(2), FZD5(1), FZD6(2), FZD9(1), GSK3B(1), LEF1(1), LRP5(1), LRP6(1), MAP3K7(2), MAPK10(1), NFATC1(2), NFATC2(1), NKD2(1), NLK(1), PLCB1(2), PLCB4(2), PPARD(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(2), PRKACA(1), PRKCA(1), PRKX(2), PSEN1(1), RAC1(1), RAC2(2), ROCK1(4), ROCK2(1), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(1), VANGL2(2), WIF1(2), WNT2(2), WNT5A(1), WNT6(2) 60132592 108 76 108 44 35 29 16 12 16 0 0.818 1.000 1.000 510 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTG1(1), ACTN3(1), AKT1(1), AKT2(1), ASH1L(4), CDK4(1), CGN(1), CLDN15(2), CLDN9(2), CSNK2A1(1), CSNK2A2(1), CTNNA2(4), CTNNA3(1), EPB41L1(1), EPB41L2(1), EPB41L3(8), GNAI1(1), GNAI2(1), HRAS(2), INADL(3), JAM2(1), LLGL2(1), MAGI3(1), MLLT4(2), MPDZ(3), MRAS(1), MYH1(4), MYH10(4), MYH13(4), MYH15(1), MYH2(1), MYH4(5), MYH6(4), MYH7(4), MYH7B(4), MYH8(3), MYH9(2), MYL2(1), MYL5(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(1), PRKCH(1), PRKCZ(2), RRAS2(1), SPTAN1(1), TJAP1(1), TJP1(4), TJP2(3), TJP3(2), VAPA(1) 72005130 111 73 111 31 43 26 12 13 17 0 0.0985 1.000 1.000 511 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM3(2), CD226(1), CD276(1), CD6(1), CD8A(1), CD8B(1), CDH1(3), CDH2(4), CDH3(2), CDH4(3), CDH5(4), CLDN15(2), CLDN9(2), CNTN2(1), CNTNAP1(6), CNTNAP2(1), ESAM(1), GLG1(2), HLA-DRA(1), HLA-F(1), HLA-G(4), ICAM3(1), ITGA6(2), ITGA9(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB8(2), JAM2(1), L1CAM(3), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEO1(1), NFASC(1), NLGN1(2), NRCAM(2), NRXN1(2), NRXN2(3), NRXN3(2), PDCD1(1), PTPRC(3), PTPRF(1), PVRL1(1), SDC3(1), SELE(1), SELP(2), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3) 55452202 102 71 100 31 38 27 11 11 15 0 0.205 1.000 1.000 512 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1D(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CHRM3(1), CHRM4(1), CMKLR1(2), CNR1(1), F2RL3(1), FPR1(1), FSHR(1), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37L1(2), GPR4(1), GPR50(2), GPR83(2), GPR87(1), HCRTR2(3), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), OR1F1(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGER2(1), SSTR1(1), SSTR2(1), SSTR3(1), TBXA2R(2), TRHR(1) 45682649 89 69 89 33 35 26 9 9 10 0 0.298 1.000 1.000 513 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(3), AKT1(1), AKT2(1), ARAF(1), BAD(1), CBL(1), CRK(1), EXOC7(1), FASN(1), GCK(1), GSK3B(1), HRAS(2), INPP5D(2), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), MAPK10(1), PCK2(2), PDE3B(1), PDPK1(1), PFKM(1), PFKP(1), PHKA1(1), PHKA2(1), PHKB(2), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(3), PPP1R3B(1), PRKAA2(3), PRKACA(1), PRKAG1(2), PRKAG2(1), PRKAG3(1), PRKAR1A(1), PRKAR1B(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(1), PYGL(2), RAF1(1), RAPGEF1(3), SHC1(2), SHC2(1), SHC3(1), SORBS1(2), SOS1(1), TSC2(2) 58992847 89 66 89 26 33 19 14 11 12 0 0.196 1.000 1.000 514 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ATF2(1), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(2), CREB3(1), DGKZ(1), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(2), GNGT1(1), GUCY1A3(2), IL6(1), ITPR1(2), ITPR2(3), ITPR3(1), MIB1(1), MYL2(1), MYLK2(2), NFKB1(2), NOS1(2), NOS3(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAMP2(1), RGS10(1), RGS11(1), RGS16(2), RGS20(1), RGS6(1), RGS7(1), RGS9(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SP1(1), TNXB(7), YWHAQ(1) 65228068 99 66 99 66 38 23 8 7 23 0 1.000 1.000 1.000 515 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ADRB1(1), EGFR(3), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRM1(4), GRM5(2), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), HRAS(2), HTR2A(3), HTR2B(1), HTR2C(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NPR2(1), PDGFRA(3), PDGFRB(1), PLCB1(2), PLCB4(2), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), SOS1(1), TJP1(4), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1) 49650221 83 62 82 30 31 17 6 10 19 0 0.581 1.000 1.000 516 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), AK5(1), AMPD1(1), AMPD2(1), AMPD3(1), ATIC(3), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(2), ENTPD6(1), ENTPD8(1), FHIT(1), GART(1), GMPR(1), GMPR2(1), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), NPR2(1), NT5C2(2), NT5M(1), PAPSS2(1), PDE10A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE7A(1), PDE8A(1), PDE8B(1), PNPT1(1), POLA1(1), POLD3(1), POLE(4), POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1), PRPS1L1(1), RRM1(2), RRM2B(1) 61319959 79 59 79 39 23 25 6 9 16 0 0.935 1.000 1.000 517 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN3(1), BCAR1(1), CDH5(4), CLDN15(2), CLDN9(2), CTNNA2(4), CTNNA3(1), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MLLT4(2), MMP2(1), MMP9(1), MSN(1), MYL2(1), MYL5(1), NCF1(1), NCF2(4), NCF4(1), NOX3(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(1), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAPGEF4(1), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(1), SIPA1(1), TXK(1), VAV1(2), VAV2(1), VAV3(4), VCAM1(1) 45267214 80 56 79 25 32 12 9 12 15 0 0.411 1.000 1.000 518 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(1), CREBBP(5), DVL1(1), DVL2(2), DVL3(1), EP300(4), FZD1(2), FZD10(1), FZD2(4), FZD4(2), FZD5(1), FZD6(2), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), HRAS(2), LEF1(1), MAPK1(1), PLCB1(2), PLCB4(2), POMC(1), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(1), TYRP1(1), WNT2(2), WNT5A(1), WNT6(2) 40468172 71 54 71 43 22 21 9 10 9 0 0.994 1.000 1.000 519 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2A(1), AMY2B(2), ASCC3(1), DDX47(4), DDX50(1), DDX51(1), ENPP1(2), ENPP3(2), ENTPD7(1), ERCC2(2), ERCC3(3), GAA(2), GBE1(2), GCK(1), HK2(1), HK3(2), MGAM(1), PGM1(1), PGM3(1), PYGL(2), RAD54L(1), RUVBL2(1), SETX(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1) 46378456 64 52 63 22 14 20 10 7 13 0 0.649 1.000 1.000 520 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), AK5(1), AMPD1(1), AMPD2(1), AMPD3(1), ATIC(3), ATP5A1(2), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(2), FHIT(1), GART(1), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), NPR2(1), NT5M(1), PAPSS2(1), PDE4A(1), PDE4C(1), PDE6B(1), PDE6C(1), PDE8A(1), POLE(4), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), PRPS1L1(1), RRM1(2) 48188590 60 50 60 29 17 15 7 10 11 0 0.926 1.000 1.000 521 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), CD48(2), FASLG(1), FCGR3A(1), FCGR3B(1), HLA-G(4), HRAS(2), IFNA10(1), IFNA13(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL2(1), LCP2(1), MAPK1(1), MICB(1), NCR1(1), NFATC1(2), NFATC2(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(1), RAC1(1), RAC2(2), RAF1(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), ULBP3(1), VAV1(2), VAV2(1), VAV3(4), ZAP70(1) 41217988 68 49 67 24 26 15 11 8 8 0 0.479 1.000 1.000 522 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(1), CACNA1S(2), CAMK2A(1), CAMK2D(1), EGFR(3), GNAS(2), GNRHR(3), HRAS(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), MAPK10(1), MMP2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCB1(2), PLCB4(2), PLD1(2), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), SOS1(1) 47728612 61 48 61 34 18 18 7 6 12 0 0.991 1.000 1.000 523 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), AKAP1(1), AKAP11(1), AKAP12(4), AKAP3(1), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(4), ARHGEF1(3), GNA12(1), GNAI2(1), GNAL(1), GNAO1(1), GNB1(1), GNB3(1), GNB5(2), GNGT1(1), HRAS(2), ITPR1(2), PDE1B(1), PDE1C(1), PDE4A(1), PDE4C(1), PDE7A(1), PDE8A(1), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), PRKD3(1) 43927605 62 47 62 35 19 13 9 10 11 0 0.988 1.000 1.000 524 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), FN3K(1), IMPA1(1), INPP4A(1), INPP5B(2), INPP5D(2), INPP5E(1), INPPL1(1), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(2), PI4KA(1), PI4KB(1), PIK3C2A(1), PIK3C2B(2), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), PRKCA(1), SYNJ1(2), SYNJ2(2) 45748529 64 45 64 20 23 16 7 6 12 0 0.386 1.000 1.000 525 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA12(3), ABCA13(7), ABCA3(2), ABCA4(5), ABCA5(5), ABCA9(2), ABCB1(4), ABCB10(1), ABCB11(1), ABCB5(2), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(1), ABCC11(3), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(2), ABCC6(1), ABCC9(1), ABCD2(1), ABCD3(1), ABCG1(1), ABCG2(1), CFTR(1), TAP1(1), TAP2(1) 44205252 57 43 57 35 16 18 9 6 8 0 0.991 1.000 1.000 526 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(1), ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL2(3), CSNK2A1(1), CSNK2A2(1), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), IMPA1(1), INPP4A(1), INPPL1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3CB(2), PIK3CG(3), PLCB1(2), PLCB4(2), PLCG1(1), PLCG2(1), PLK3(4), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2), VRK1(1) 41687204 66 43 66 22 20 19 14 4 9 0 0.412 1.000 1.000 527 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(1), C1S(1), C3(1), C3AR1(1), C6(2), C8B(1), C9(1), CD46(2), CD55(1), CFB(3), CFH(6), CPB2(1), CR1(1), F10(1), F11(1), F12(1), F13A1(1), F13B(2), F2(1), F3(1), F5(5), F7(1), F8(2), FGA(2), KLKB1(1), MASP1(1), MASP2(1), PLAT(1), PLAU(2), PLG(2), PROS1(2), SERPIND1(2), VWF(7) 33903267 61 42 61 22 15 21 9 8 8 0 0.707 1.000 1.000 528 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(3), ACTR3(1), AKT1(1), AKT2(1), ARHGEF6(1), BCAR1(1), CDKN2A(1), CRK(1), EPHB2(3), GRB7(1), ITGA10(1), ITGA11(1), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), MAP2K4(1), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MRAS(1), MYLK(4), MYLK2(2), P4HB(1), PAK2(1), PAK6(1), PAK7(1), PIK3CB(2), PLCG1(1), PLCG2(1), PTK2(2), RAF1(1), ROCK1(4), ROCK2(1), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(2) 44313002 60 42 60 23 13 20 9 7 11 0 0.726 1.000 1.000 529 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), CCKBR(1), CCR2(1), CELSR1(2), CELSR2(4), CELSR3(4), CHRM3(1), EMR2(4), FSHR(1), GNRHR(3), GPR116(1), GPR132(2), GPR133(2), GPR17(1), GPR18(1), GPR55(1), GPR56(1), GPR84(2), GRM1(4), LPHN2(2), LPHN3(6), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2) 25073193 51 40 48 21 23 11 6 6 5 0 0.547 1.000 1.000 530 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(1), AKT2(1), CARD11(1), CBL(1), CD8A(1), CD8B(1), CDK4(1), HRAS(2), IL4(1), ITK(1), LCP2(1), NFATC1(2), NFATC2(1), NFKB1(2), PAK2(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPRC(3), SOS1(1), TNF(1), VAV1(2), VAV2(1), VAV3(4), ZAP70(1) 37309788 50 37 49 20 17 14 7 5 7 0 0.688 1.000 1.000 531 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), DAXX(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MEF2D(2), NFKB1(2), PAK2(1), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), SHC1(2), SP1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(2) 35337567 51 35 51 17 18 10 11 5 7 0 0.521 1.000 1.000 532 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(2), CPSF2(1), CPSF3(1), CSTF2T(1), CSTF3(1), DHX15(1), DHX38(1), DHX8(1), LOC440563(2), METTL3(1), PHF5A(1), POLR2A(2), PPM1G(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(3), PTBP1(2), PTBP2(1), RBM17(1), RBM5(1), SF3A1(2), SF3A3(1), SF3B1(2), SF3B5(1), SNRPA(1), SNRPD2(1), SNRPD3(1), SNRPN(1), SUPT5H(2) 39358825 41 35 41 13 10 8 12 3 8 0 0.567 1.000 1.000 533 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(9), CACNA1B(1), GNAS(2), GNB1(1), GNB3(1), GRM4(2), ITPR3(1), KCNB1(3), PRKACA(1), PRKX(2), SCNN1B(2), TAS1R2(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R46(1), TAS2R5(1), TRPM5(1) 21466902 42 33 42 19 19 7 4 5 7 0 0.826 1.000 1.000 534 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR3(1), AKT1(1), AKT2(1), ARHGEF11(3), BTK(1), CFL1(1), CFL2(1), INPPL1(1), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PDK1(1), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(1), ROCK1(4), ROCK2(1) 25183311 40 33 40 15 11 10 5 4 10 0 0.780 1.000 1.000 535 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP5(2), BMP6(1), BMP7(3), CSNK1A1L(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(2), GLI3(1), GSK3B(1), HHIP(2), LRP2(3), PRKACA(1), PRKX(2), PTCH1(2), PTCH2(4), SHH(2), STK36(1), SUFU(1), WNT2(2), WNT5A(1), WNT6(2) 22934510 42 32 42 24 15 10 6 6 5 0 0.949 1.000 1.000 536 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD1B(2), CD1C(1), CD1E(1), CD38(1), CD55(1), CD8A(1), CD8B(1), CR1(1), CSF1R(1), CSF2RA(2), CSF3R(1), FCER2(1), FLT3(1), GP5(2), HLA-DRA(1), IL11RA(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL7R(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(1) 30608575 39 32 39 17 12 15 3 2 7 0 0.746 1.000 1.000 537 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP3A7(1), CYP4F8(1), DDC(1), EHHADH(3), KMO(1), KYNU(2), TDO2(1), TPH1(1), WARS(1) 20628695 37 31 37 15 10 11 9 1 6 0 0.735 1.000 1.000 538 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(2), ASAH1(2), CAV3(1), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), PITX2(1), RAC1(1), RYR1(7) 17249114 32 30 32 12 18 4 2 1 7 0 0.618 1.000 1.000 539 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(2), CCND3(1), DVL1(1), DVL2(2), DVL3(1), FZD1(2), FZD10(1), FZD2(4), FZD5(1), FZD6(2), FZD9(1), GSK3B(1), LDLR(1), MAPK10(1), PLAU(2), PPP2R5E(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(2), WNT5A(1), WNT6(2) 22061346 36 29 36 19 11 8 6 5 6 0 0.926 1.000 1.000 540 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(1), AKT2(1), CXCL9(1), IFNA10(1), IFNA13(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(1), MAP2K4(1), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), NFKB1(2), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), RAC1(1), RELA(1), RIPK1(1), STAT1(1), TLR7(1), TLR9(1), TNF(1) 32912382 35 28 35 18 13 8 6 3 5 0 0.932 1.000 1.000 541 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), CSK(1), EGFR(3), JAM2(1), MAP2K4(1), MAPK10(1), MET(1), NFKB1(2), NOD1(1), PLCG1(1), PLCG2(1), RAC1(1), RELA(1), TJP1(4) 26362358 34 27 34 13 7 15 7 2 3 0 0.687 1.000 1.000 542 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DAXX(1), HRAS(2), MAP2K4(1), MAP3K1(1), MAP3K5(1), MAP3K7(2), MAPKAPK5(1), MEF2C(2), MEF2D(2), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(2) 13726555 30 27 30 11 11 4 10 4 1 0 0.659 1.000 1.000 543 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(1), ASCC3(1), DDX47(4), DDX50(1), DDX51(1), DHFR(1), ENTPD7(1), ERCC2(2), ERCC3(3), RAD54L(1), RUVBL2(1), SETX(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3) 23588428 28 26 27 15 8 8 4 3 5 0 0.951 1.000 1.000 544 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(2), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(2), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), FUT6(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), PIGT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1), ST8SIA1(1) 18248225 33 26 33 14 16 6 2 4 4 1 0.747 1.000 1.000 545 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 EGFR(3), ERBB2(1), ERBB4(1), ETV6(1), FMN2(3), MAPK1(1), NOTCH1(2), NOTCH2(3), NOTCH3(3), NOTCH4(2), PIWIL1(3), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(1) 19188233 28 26 28 10 8 9 4 0 7 0 0.633 1.000 1.000 546 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(1), F12(1), F13B(2), F2(1), F5(5), F7(1), F8(2), FGA(2), LPA(1), PLAT(1), PLAU(2), PLG(2), SERPINB2(1), VWF(7) 13200847 30 25 30 15 6 15 4 2 3 0 0.930 1.000 1.000 547 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), DDC(1), EHHADH(3), INMT(1), KMO(1), KYNU(2), METTL6(1), PRMT3(1), PRMT5(1), TDO2(1), TPH1(1), WARS(1) 22708350 29 25 28 21 5 11 5 1 7 0 0.995 1.000 1.000 548 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1D(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), CHRM3(1), CHRM4(1), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1) 9659587 26 25 26 11 14 6 2 2 2 0 0.479 1.000 1.000 549 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 AKT1(1), CAMK1(2), CAMK4(2), CREBBP(5), F2(1), GSK3B(1), HRAS(2), LIF(1), MAPK1(1), MEF2C(2), MYH2(1), NFATC1(2), NFATC2(1), NPPA(1), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RAF1(1), SYT1(1) 18250638 31 25 31 12 11 7 5 5 3 0 0.642 1.000 1.000 550 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(4), B3GALT4(1), CDR1(1), DGKI(2), IL6ST(2), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL5(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), UBB(1), UBC(1) 19686362 27 25 27 13 8 5 4 2 8 0 0.974 1.000 1.000 551 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR3(1), AKT1(1), CFL1(1), CFL2(1), FLNC(2), FSCN2(1), FSCN3(4), LIMK1(1), MYH2(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PFN2(2), ROCK1(4), ROCK2(1) 17955221 30 25 30 12 8 11 4 5 2 0 0.667 1.000 1.000 552 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), FLT1(1), FLT4(2), KDR(5), NOS3(1), PDE2A(1), PDE3B(1), PRKAR1A(1), PRKAR1B(1), RYR2(10), SYT1(1) 15254353 25 24 25 18 11 8 1 1 4 0 0.982 1.000 1.000 553 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), ACAT1(1), AKR1B10(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), BBOX1(1), DOT1L(2), EHHADH(3), EHMT2(1), NSD1(1), PLOD1(2), PLOD3(1), RDH12(1), SETD1A(3), SETDB1(2), SHMT1(3), SHMT2(1) 21817975 28 23 27 12 9 9 4 1 5 0 0.746 1.000 1.000 554 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(1), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(1), DDC(1), ESCO1(5), FAH(1), GOT1(1), HGD(1), HPD(1), METTL6(1), PNMT(1), PRMT3(1), PRMT5(1), TPO(1), TYRP1(1) 22283940 25 23 25 11 6 6 1 2 10 0 0.822 1.000 1.000 555 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 AR(1), ESR1(1), HNF4A(1), NR1D2(1), NR1H3(1), NR1I2(2), NR1I3(1), NR2E1(1), NR2F1(1), NR2F2(1), NR5A2(1), PGR(2), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(2), RXRB(1), RXRG(1), THRA(2), VDR(1) 15776963 27 23 27 10 14 4 3 2 4 0 0.514 1.000 1.000 556 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH4A1(1), AOC2(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), DAO(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(4), P4HA2(1), P4HB(1), PYCR1(1) 16632246 26 22 26 18 8 9 3 3 3 0 0.991 1.000 1.000 557 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY9(2), ARF4(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(1), PRKCA(1), SEC61A1(1), SEC61A2(2), TRIM23(1) 13835611 26 22 26 11 8 7 5 3 3 0 0.767 1.000 1.000 558 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDH7A1(2), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGK2(1), PGM1(1), PGM3(1), TPI1(1) 21856932 24 21 23 11 7 6 4 3 4 0 0.794 1.000 1.000 559 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), CARS2(2), DARS2(1), EPRS(2), FARSB(2), GARS(1), HARS(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(2), NARS2(1), QARS(2), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1) 20336063 29 21 29 11 10 6 3 3 7 0 0.805 1.000 1.000 560 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(2), ATF2(1), BMP5(2), BMP7(3), BMPR2(1), CHRD(1), DVL1(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), MYL2(1), NPPA(1), NPPB(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1) 13091037 26 20 26 12 10 4 6 2 4 0 0.795 1.000 1.000 561 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), SYT1(1) 9634646 20 20 20 11 6 7 1 5 1 0 0.888 1.000 1.000 562 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(1), ARHGEF11(3), DLG4(1), LPA(1), MAP2K4(1), MAP3K1(1), MAP3K5(1), NFKB1(2), PDK1(1), PHKA2(1), PIK3CB(2), PLD1(2), PTK2(2), ROCK1(4), ROCK2(1), TBXA2R(2) 18395826 27 20 27 14 7 9 3 2 6 0 0.915 1.000 1.000 563 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), JAK2(2), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT5A(1), SYT1(1) 15030906 24 19 24 10 9 8 5 2 0 0 0.677 1.000 1.000 564 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(1), B4GALT1(2), B4GALT2(2), GAA(2), GALK1(1), GCK(1), HK2(1), HK3(2), LCT(3), MGAM(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH12(1), UGP2(1) 14572472 22 19 22 11 10 5 2 3 2 0 0.788 1.000 1.000 565 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT(1), AKR1B10(1), AMT(1), AOC2(1), CBS(1), CHDH(2), DAO(2), GARS(1), GCAT(1), GLDC(2), RDH12(1), SARDH(2), SHMT1(3), SHMT2(1), TARS(1), TARS2(1) 16048427 23 19 23 10 7 7 1 1 7 0 0.831 1.000 1.000 566 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), DAO(2), EPRS(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(4), P4HA2(1), PYCR1(1) 13532006 20 19 20 14 7 5 2 3 3 0 0.989 1.000 1.000 567 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(1), ACY3(1), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDH7A1(2), AMDHD1(1), AOC2(1), CNDP1(2), DDC(1), FTCD(1), HARS(1), METTL6(1), PRMT3(1), PRMT5(1), UROC1(3) 14855511 20 18 19 14 7 5 2 1 5 0 0.977 1.000 1.000 568 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(5), CSK(1), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(1) 8627894 18 17 18 12 5 6 2 4 1 0 0.978 1.000 1.000 569 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(5), CSK(1), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(1) 8627894 18 17 18 12 5 6 2 4 1 0 0.978 1.000 1.000 570 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(1), EGFR(3), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK1(1), NFKB1(2), PRKCA(1), PRKCH(1), RAF1(1), RELA(1), RIPK1(1), SP1(1), TNF(1), TRAF2(2) 18448692 22 17 22 12 4 10 4 2 2 0 0.906 1.000 1.000 571 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(1), DUSP8(2), GCK(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAPK10(1), PAPPA(3), SHC1(2) 18631836 24 17 24 12 9 5 2 2 6 0 0.881 1.000 1.000 572 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), RAF1(1), SYT1(1) 13083355 19 16 19 9 4 5 5 5 0 0 0.845 1.000 1.000 573 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), ALDH5A1(1), CAD(3), EPRS(2), GAD2(4), GFPT2(2), GNPNAT1(1), GOT1(1), NAGK(1), QARS(2) 14841788 18 16 18 13 8 4 1 2 3 0 0.989 1.000 1.000 574 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), HRAS(2), JAK1(2), JAK3(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1), SYK(2) 8743300 15 15 15 9 6 6 3 0 0 0 0.904 1.000 1.000 575 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), ALDH5A1(1), CAD(3), EPRS(2), GAD2(4), GOT1(1), QARS(2) 12462936 14 14 14 12 6 4 1 1 2 0 0.993 1.000 1.000 576 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(2), PRKAG2(1), PRKAR1A(1), PRKAR1B(1) 5759092 13 12 13 7 3 5 2 3 0 0 0.902 1.000 1.000 577 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(3), GTF2E2(1), POLR1A(4), POLR1B(1), POLR2A(2), POLR3B(1), TAF5(1) 13121486 13 12 12 11 5 4 1 2 1 0 0.993 1.000 1.000 578 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(1), GSK3B(1), PRKAR1A(1), PRKAR1B(1), SHH(2), SUFU(1) 6275582 12 11 12 11 2 1 2 5 2 0 0.993 1.000 1.000 579 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), HRAS(2), JAK2(2), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1) 8030205 12 10 12 8 5 5 2 0 0 0 0.919 1.000 1.000 580 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSE(2), ASAH1(2), LCT(3), NEU1(1), PPAP2B(1) 9103786 10 9 10 5 5 3 2 0 0 0 0.729 1.000 1.000 581 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), AOC2(1), CNDP1(2), DDC(1), HARS(1) 9132942 12 9 12 10 3 5 1 1 2 0 0.984 1.000 1.000 582 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ALDH18A1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), ARG2(1), ASL(1), SAT2(1) 11052917 10 9 9 11 5 2 1 1 1 0 0.996 1.000 1.000 583 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA1(1), CA14(1), CA2(2), CA3(1), CA6(1), CA8(2), CA9(1) 7951787 10 9 10 7 4 3 0 3 0 0 0.953 1.000 1.000 584 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA1(1), CA14(1), CA2(2), CA3(1), CA6(1), CA8(2), CA9(1) 7111673 10 9 10 7 4 3 0 3 0 0 0.954 1.000 1.000 585 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(2), JAK3(2), PIAS3(2), PTPRU(3) 5176325 11 9 11 5 6 3 2 0 0 0 0.751 1.000 1.000 586 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(4), POLG(1), POLL(1), POLQ(3) 6280018 9 8 9 5 3 3 1 2 0 0 0.864 1.000 1.000 587 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1) 3605809 7 7 7 5 0 3 1 3 0 0 0.969 1.000 1.000 588 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(1) 4906968 7 7 7 8 0 4 1 2 0 0 0.997 1.000 1.000 589 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(1) 2473523 7 7 7 5 0 4 2 1 0 0 0.959 1.000 1.000 590 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT3(1), GALNT4(1), ST3GAL1(1), WBSCR17(2) 5401342 7 7 7 5 3 1 1 2 0 0 0.942 1.000 1.000 591 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(2), PRKAR1A(1), PRKAR1B(1), RAP2B(1) 5537557 7 7 7 7 0 4 1 2 0 0 0.991 1.000 1.000 592 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(1), NCOA1(1), NCOR2(1), POLR2A(2) 9394937 8 7 7 11 5 2 0 0 1 0 0.998 1.000 1.000 593 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 LTA(1), MAP2K4(1), MAP3K1(1), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TRAF2(2) 9091469 10 7 10 6 1 7 1 1 0 0 0.880 1.000 1.000 594 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(1), GOT1(1), ME1(1), ME3(1), TKT(1), TPI1(1) 6783012 6 6 6 4 1 3 0 2 0 0 0.891 1.000 1.000 595 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(1), FUT2(1), FUT3(1) 2700700 6 6 6 4 0 3 0 3 0 0 0.908 1.000 1.000 596 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IL4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1) 3972874 6 6 6 5 2 2 2 0 0 0 0.951 1.000 1.000 597 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), UGDH(1) 3210279 5 5 4 4 2 1 2 0 0 0 0.933 1.000 1.000 598 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 HLA-DRA(1), PTPRC(3), ZAP70(1) 3382320 5 5 5 4 2 1 1 1 0 0 0.930 1.000 1.000 599 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(1), FUT3(1), FUT6(1) 1906720 4 4 4 3 1 2 0 1 0 0 0.865 1.000 1.000 600 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 HLA-DRA(1), ITK(1), PIK3R1(2) 3968436 4 4 4 4 4 0 0 0 0 0 0.961 1.000 1.000 601 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 ITGAL(3), ITGB2(2) 3286869 5 4 5 5 3 1 0 1 0 0 0.941 1.000 1.000 602 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL4(1), ITGAX(1), TLR7(1), TLR9(1) 6968430 4 4 4 3 4 0 0 0 0 0 0.866 1.000 1.000 603 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), NQO1(1), SQLE(1) 4162143 3 3 3 4 3 0 0 0 0 0 0.972 1.000 1.000 604 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 POLR2A(2), PRKAR1A(1), PRKAR1B(1) 4842668 4 3 4 4 2 0 1 1 0 0 0.958 1.000 1.000 605 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(1), APOBEC3B(2) 2744812 3 3 3 3 2 1 0 0 0 0 0.959 1.000 1.000 606 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), IL6(1), LDLR(1) 1995104 3 3 3 3 1 2 0 0 0 0 0.945 1.000 1.000 607 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(1) 2041726 2 2 2 3 1 1 0 0 0 0 0.975 1.000 1.000 608 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(1), UGP2(1) 1839977 2 2 2 2 0 0 1 1 0 0 0.959 1.000 1.000 609 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 689103 1 1 1 2 0 1 0 0 0 0 0.975 1.000 1.000 610 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 1159510 1 1 1 2 0 1 0 0 0 0 0.978 1.000 1.000 611 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1) 1446953 1 1 1 2 0 0 1 0 0 0 0.984 1.000 1.000 612 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 1706638 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 640187 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 1587635 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 1200781 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 425984 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000