Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Syndecan-1-mediated signaling events	57.0	1948.0	34.0	-0.698	0.014	1000.0	-1000.0	-0.055	-1000.0
TCGA08_retinoblastoma	48.0	391.0	8.0	-0.187	0.081	1000.0	-1000.0	-0.018	-1000.0
Reelin signaling pathway	39.0	2230.0	56.0	-0.484	0.035	1000.0	-1000.0	-0.07	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	24.0	1313.0	54.0	-0.479	0.021	1000.0	-1000.0	-0.084	-1000.0
Glypican 1 network	20.0	1007.0	48.0	-0.34	0.024	1000.0	-1000.0	-0.041	-1000.0
Osteopontin-mediated events	17.0	651.0	38.0	-0.177	0.019	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by the Hedgehog family	17.0	888.0	52.0	-0.178	0.164	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	17.0	1151.0	67.0	-0.33	0.048	1000.0	-1000.0	-0.055	-1000.0
IL23-mediated signaling events	17.0	1046.0	60.0	-0.461	0.018	1000.0	-1000.0	-0.183	-1000.0
IL4-mediated signaling events	16.0	1528.0	91.0	-0.633	0.476	1000.0	-1000.0	-0.211	-1000.0
FOXA2 and FOXA3 transcription factor networks	16.0	754.0	46.0	-0.566	0.017	1000.0	-1000.0	-0.163	-1000.0
Caspase cascade in apoptosis	14.0	1100.0	74.0	-0.129	0.092	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1116.0	78.0	-0.127	0.044	1000.0	-1000.0	-0.079	-1000.0
TCGA08_p53	12.0	86.0	7.0	-0.138	0.07	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	11.0	677.0	61.0	-0.432	0.186	1000.0	-1000.0	-0.054	-1000.0
BMP receptor signaling	11.0	899.0	81.0	-0.25	0.036	1000.0	-1000.0	-0.081	-1000.0
Glucocorticoid receptor regulatory network	11.0	1339.0	114.0	-0.554	0.241	1000.0	-1000.0	-0.068	-1000.0
Endothelins	11.0	1123.0	96.0	-0.373	0.124	1000.0	-1000.0	-0.082	-1000.0
Canonical Wnt signaling pathway	10.0	523.0	51.0	-0.433	0.199	1000.0	-1000.0	-0.062	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	314.0	31.0	-0.418	0.012	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Rods	10.0	545.0	52.0	-0.266	0.012	1000.0	-1000.0	-0.075	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	182.0	17.0	-0.061	0.023	1000.0	-1000.0	-0.038	-1000.0
Ephrin A  reverse signaling	9.0	68.0	7.0	-0.079	0.0	1000.0	-1000.0	-0.019	-1000.0
Syndecan-2-mediated signaling events	9.0	628.0	69.0	-0.348	0.033	1000.0	-1000.0	-0.028	-1000.0
IL1-mediated signaling events	9.0	597.0	62.0	-0.166	0.016	1000.0	-1000.0	-0.087	-1000.0
BCR signaling pathway	9.0	973.0	99.0	-0.125	0.015	1000.0	-1000.0	-0.082	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	149.0	17.0	-0.114	0.017	1000.0	-1000.0	-0.044	-1000.0
HIF-1-alpha transcription factor network	8.0	656.0	76.0	-0.733	0.019	1000.0	-1000.0	-0.192	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	816.0	97.0	-0.129	0.028	1000.0	-1000.0	-0.082	-1000.0
S1P5 pathway	8.0	149.0	17.0	-0.126	0.065	1000.0	-1000.0	-0.029	-1000.0
Angiopoietin receptor Tie2-mediated signaling	8.0	784.0	88.0	-0.246	0.067	1000.0	-1000.0	-0.088	-1000.0
amb2 Integrin signaling	7.0	585.0	82.0	-0.19	0.017	1000.0	-1000.0	-0.051	-1000.0
Ephrin B reverse signaling	7.0	351.0	48.0	-0.098	0.039	1000.0	-1000.0	-0.053	-1000.0
Syndecan-3-mediated signaling events	7.0	277.0	35.0	-0.348	0.035	1000.0	-1000.0	-0.034	-1000.0
Effects of Botulinum toxin	7.0	202.0	26.0	-0.085	0.021	1000.0	-1000.0	-0.043	-1000.0
Wnt signaling	7.0	55.0	7.0	-0.147	0.012	1000.0	-1000.0	-0.032	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	229.0	34.0	-0.04	0.012	1000.0	-1000.0	-0.046	-1000.0
Visual signal transduction: Cones	6.0	252.0	38.0	-0.113	0.016	1000.0	-1000.0	-0.033	-1000.0
p75(NTR)-mediated signaling	6.0	839.0	125.0	-0.861	0.035	1000.0	-1000.0	-0.083	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	421.0	68.0	-0.418	0.035	1000.0	-1000.0	-0.111	-1000.0
Plasma membrane estrogen receptor signaling	6.0	546.0	86.0	-0.269	0.066	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by PRL	6.0	206.0	34.0	-0.119	0.038	1000.0	-1000.0	-0.03	-1000.0
S1P4 pathway	6.0	161.0	25.0	-0.126	0.023	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	151.0	28.0	-0.126	0.023	1000.0	-1000.0	-0.029	-1000.0
Nectin adhesion pathway	5.0	348.0	63.0	-0.656	0.038	1000.0	-1000.0	-0.067	-1000.0
Retinoic acid receptors-mediated signaling	5.0	347.0	58.0	-0.248	0.024	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	244.0	44.0	-0.033	0.017	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	5.0	476.0	85.0	-0.098	0.05	1000.0	-1000.0	-0.074	-1000.0
Nongenotropic Androgen signaling	5.0	264.0	52.0	-0.126	0.022	1000.0	-1000.0	-0.051	-1000.0
LPA receptor mediated events	5.0	559.0	102.0	-0.163	0.024	1000.0	-1000.0	-0.078	-1000.0
IL12-mediated signaling events	4.0	370.0	87.0	-0.131	0.038	1000.0	-1000.0	-0.147	-1000.0
ErbB4 signaling events	4.0	296.0	69.0	-0.286	0.068	1000.0	-1000.0	-0.085	-1000.0
Thromboxane A2 receptor signaling	4.0	422.0	105.0	-0.182	0.072	1000.0	-1000.0	-0.07	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	230.0	52.0	-0.133	0.028	1000.0	-1000.0	-0.046	-1000.0
HIF-2-alpha transcription factor network	4.0	211.0	43.0	-0.219	0.105	1000.0	-1000.0	-0.077	-1000.0
S1P1 pathway	4.0	162.0	36.0	-0.126	0.013	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	380.0	93.0	-0.038	0.028	1000.0	-1000.0	-0.081	-1000.0
IL27-mediated signaling events	4.0	218.0	51.0	-0.231	0.067	1000.0	-1000.0	-0.067	-1000.0
EGFR-dependent Endothelin signaling events	4.0	89.0	21.0	-0.066	0.018	1000.0	-1000.0	-0.058	-1000.0
S1P3 pathway	4.0	208.0	42.0	-0.125	0.024	1000.0	-1000.0	-0.032	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	463.0	136.0	-0.258	0.071	1000.0	-1000.0	-0.059	-1000.0
Noncanonical Wnt signaling pathway	3.0	87.0	26.0	-0.147	0.012	1000.0	-1000.0	-0.056	-1000.0
Arf6 signaling events	3.0	198.0	62.0	-0.126	0.028	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	3.0	255.0	76.0	-0.273	0.042	1000.0	-1000.0	-0.066	-1000.0
IFN-gamma pathway	3.0	219.0	68.0	-0.05	0.028	1000.0	-1000.0	-0.092	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	258.0	82.0	-0.116	0.012	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	48.0	15.0	-0.044	0.023	1000.0	-1000.0	-0.031	-1000.0
Integrins in angiogenesis	3.0	293.0	84.0	-0.18	0.029	1000.0	-1000.0	-0.075	-1000.0
Regulation of Telomerase	3.0	330.0	102.0	-0.373	0.037	1000.0	-1000.0	-0.1	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	129.0	33.0	-0.18	0.032	1000.0	-1000.0	-0.036	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	360.0	120.0	-0.084	0.07	1000.0	-1000.0	-0.069	-1000.0
Regulation of Androgen receptor activity	3.0	247.0	70.0	-0.217	0.023	1000.0	-1000.0	-0.069	-1000.0
Aurora B signaling	3.0	227.0	67.0	-0.378	0.075	1000.0	-1000.0	-0.048	-1000.0
ErbB2/ErbB3 signaling events	2.0	153.0	65.0	-0.045	0.039	1000.0	-1000.0	-0.068	-1000.0
Coregulation of Androgen receptor activity	2.0	196.0	76.0	-0.174	0.042	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	2.0	169.0	60.0	-0.133	0.031	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	78.0	37.0	-0.107	0.035	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	2.0	85.0	40.0	-0.049	0.022	1000.0	-1000.0	-0.019	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	185.0	83.0	-0.25	0.058	1000.0	-1000.0	-0.056	-1000.0
Glypican 2 network	2.0	9.0	4.0	0.002	0.007	1000.0	-1000.0	-0.021	-1000.0
IL6-mediated signaling events	2.0	153.0	75.0	-0.051	0.045	1000.0	-1000.0	-0.086	-1000.0
VEGFR1 specific signals	2.0	119.0	56.0	-0.016	0.036	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	2.0	195.0	97.0	-0.151	0.038	1000.0	-1000.0	-0.072	-1000.0
Cellular roles of Anthrax toxin	1.0	50.0	39.0	-0.029	0.012	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	107.0	65.0	-0.125	0.046	1000.0	-1000.0	-0.071	-1000.0
EPO signaling pathway	1.0	68.0	55.0	-0.008	0.041	1000.0	-1000.0	-0.087	-1000.0
PLK1 signaling events	1.0	90.0	85.0	-0.04	0.029	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	1.0	112.0	76.0	-0.066	0.037	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	1.0	56.0	47.0	-0.029	0.022	1000.0	-1000.0	-0.046	-1000.0
Regulation of p38-alpha and p38-beta	1.0	62.0	54.0	-0.089	0.031	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	1.0	39.0	26.0	-0.028	0.036	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	77.0	74.0	-0.066	0.053	1000.0	-1000.0	-0.075	-1000.0
Class I PI3K signaling events	1.0	95.0	73.0	-0.089	0.029	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	1.0	72.0	71.0	-0.031	0.031	1000.0	-1000.0	-0.054	-1000.0
Insulin Pathway	1.0	107.0	74.0	-0.044	0.031	1000.0	-1000.0	-0.075	-1000.0
Rapid glucocorticoid signaling	1.0	24.0	20.0	-0.001	0.013	1000.0	-1000.0	-0.019	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.01	0.01	1000.0	-1000.0	-0.012	-1000.0
FOXM1 transcription factor network	1.0	73.0	51.0	-0.183	0.069	1000.0	-1000.0	-0.229	-1000.0
LPA4-mediated signaling events	0.0	5.0	12.0	-0.014	0.013	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	0.009	0.036	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	0.0	14.0	39.0	-0.004	0.059	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by HDAC Class II	0.0	60.0	75.0	-0.024	0.031	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	0.0	14.0	57.0	-0.029	0.048	1000.0	-1000.0	-0.065	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.007	0.013	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.01	0.037	1000.0	-1000.0	-0.047	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	3.0	5.0	0.008	0.015	1000.0	-1000.0	-0.013	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	30.0	85.0	-0.014	0.046	1000.0	-1000.0	-0.066	-1000.0
Arf6 downstream pathway	0.0	36.0	43.0	-0.021	0.024	1000.0	-1000.0	-0.048	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.023	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	0.0	7.0	32.0	-0.007	0.034	1000.0	-1000.0	-0.049	-1000.0
PDGFR-alpha signaling pathway	0.0	30.0	44.0	-0.003	0.03	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	0.0	1.0	53.0	-0.001	0.029	1000.0	-1000.0	-0.055	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	7.0	68.0	-0.032	0.043	1000.0	-1000.0	-0.044	-1000.0
TRAIL signaling pathway	0.0	39.0	48.0	-0.04	0.034	1000.0	-1000.0	-0.045	-1000.0
ceramide signaling pathway	0.0	12.0	49.0	-0.0	0.038	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class I	0.0	29.0	104.0	-0.024	0.041	1000.0	-1000.0	-0.046	-1000.0
FoxO family signaling	0.0	42.0	64.0	-0.1	0.099	1000.0	-1000.0	-0.081	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	6.0	36.0	-0.031	0.033	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	0.0	2.0	31.0	0.0	0.038	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	0.0	57.0	58.0	-0.063	0.054	1000.0	-1000.0	-0.076	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	21.0	45.0	-0.006	0.051	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	66.0	125.0	-0.002	0.063	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	28.0	76.0	-0.011	0.045	1000.0	-1000.0	-0.078	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.031	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by STAT5	0.0	11.0	22.0	0.004	0.055	1000.0	-1000.0	-0.066	-1000.0
IGF1 pathway	0.0	27.0	57.0	-0.02	0.024	1000.0	-1000.0	-0.076	-1000.0
E-cadherin signaling in keratinocytes	0.0	32.0	43.0	-0.048	0.039	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.024	1000.0	-1000.0	-0.025	-1000.0
p38 MAPK signaling pathway	0.0	34.0	44.0	-0.029	0.028	1000.0	-1000.0	-0.059	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.0	0.025	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.035	1000.0	-1000.0	-0.027	-1000.0
Total	714	40870	7203	-20.3090971853	5.79053101845	131000	-131000	-7.91332642475	-131000