HotNet pathway analysis of mutation and copy number data
Thyroid Adenocarcinoma (Primary solid tumor)
15 January 2014
|
analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C1P55KZG
Overview
Introduction
Summary
There were 7 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 7 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 7 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| C19orf57(7),RUNX1T1(5),VCL(10) | 3 | 0.028 | 1 |
| EPHA4(10),NGEF(10),ARHGEF15(5) | 3 | 0.028 | 1 |
| PTEN(10),CTNND2(5),MAGI2(1) | 3 | 0.028 | 1 |
| CUX1(2),SERPINB3(5),ARSA(68),TG(7) | 4 | 0.018 | 1 |
| PHF23(5),RPL18A(6),MAPK8IP2(69),LRSAM1(1) | 4 | 0.018 | 1 |
| PIAS2(5),CHAF1A(6),MBD1(4),GTF2IRD1(2) | 4 | 0.018 | 1 |
| PLXNB2(68),SLC1A6(6),DLG5(12),ABCA1(1) | 4 | 0.018 | 1 |
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
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