rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(18), DAXX(1), HRAS(6), PAX3(4), PML(3), RARA(3), RB1(19), SIRT1(1), SP100(6), TNFRSF1B(3), TP53(75)	3649856	139	81	109	8	41	1	51	7	39	0	2.12e-08	<1.00e-15	<3.08e-13
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CCND1(1), CDK2(1), CDK4(2), CDKN1A(18), CDKN1B(5), CDKN2A(8), E2F1(1), E2F2(1), PRB1(1), TP53(75)	1619397	114	76	88	5	28	0	39	5	42	0	2.50e-07	<1.00e-15	<3.08e-13
3	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(1), SP1(3), SP3(2), TP53(75), WT1(2)	1363520	84	68	59	4	23	1	34	5	21	0	8.73e-06	3.77e-15	7.75e-13
4	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), HSPA1A(2), IFNG(1), IFNGR2(2), IKBKB(4), JAK2(2), NFKB1(1), NFKBIA(2), RB1(19), RELA(2), TNFRSF1B(3), TP53(75), USH1C(1), WT1(2)	3492287	117	73	90	6	33	2	40	5	37	0	1.31e-07	5.11e-15	7.86e-13
5	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(6), DNAJC3(2), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), TP53(75)	1894134	90	67	65	4	27	0	36	4	23	0	5.00e-06	8.44e-15	1.04e-12
6	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDK2(1), CUL1(8), E2F1(1), FBXW7(16), RB1(19)	1585537	45	36	38	1	14	1	6	2	22	0	0.000405	1.35e-13	1.38e-11
7	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(19), BAX(1), CCND1(1), CDK2(1), CDK4(2), CDKN1A(18), E2F1(1), GADD45A(1), PCNA(1), RB1(19), TP53(75)	3493410	140	87	112	12	36	2	41	8	53	0	0.000286	1.65e-12	1.45e-10
8	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCNB1(1), CCND1(1), CCND3(5), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), E2F1(1), RB1(19), RBL1(1)	3072916	74	51	71	5	19	2	10	3	40	0	0.00213	5.47e-12	4.21e-10
9	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), CDKN2A(8), E2F1(1), MYC(1), PIK3CA(26), PIK3R1(2), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), RAC1(1), RB1(19), TBX2(3), TP53(75)	3902579	149	79	107	12	57	4	40	9	39	0	8.02e-07	8.37e-12	5.73e-10
10	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN1B(5), E2F1(1), HRAS(6), MAPK3(3), NFKB1(1), NFKBIA(2), PIK3CA(26), PIK3R1(2), RAC1(1), RAF1(1), RB1(19), RELA(2)	3908128	92	64	73	8	40	3	9	5	35	0	0.00102	1.05e-09	6.45e-08
11	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(6), ATM(19), BAX(1), CDKN1A(18), CPB2(3), CSNK1A1(3), GADD45A(1), HIF1A(1), HSPA1A(2), MAPK8(4), NFKBIB(4), TP53(75)	4011622	137	89	111	15	40	2	43	11	41	0	0.00187	3.78e-09	2.12e-07
12	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(19), CDC25A(1), CDK2(1), CDK4(2), CHEK1(1), MYT1(3), RB1(19), TP53(75), WEE1(2)	3385655	123	79	96	13	35	3	38	9	38	0	0.00144	2.66e-08	1.37e-06
13	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(4), ATM(19), ATR(3), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), E2F1(1), HDAC1(1), RB1(19), SKP2(1), TGFB3(1), TP53(75)	5799044	164	93	136	15	47	3	45	9	60	0	5.10e-05	2.93e-08	1.39e-06
14	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(19), ATR(3), CHEK1(1), CHEK2(5), TP53(75)	3083402	103	77	78	10	35	1	37	7	23	0	0.00597	6.36e-08	2.80e-06
15	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT3(1), CDKN1A(18), HRAS(6), MAP2K1(1), NGFR(3), NTRK1(4), PIK3CA(26), PIK3CD(3), SOS1(5)	3134093	67	51	50	6	36	2	9	5	15	0	0.00327	3.58e-06	0.000147
16	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CDKN1B(5), CUL1(8), E2F1(1), RB1(19), SKP2(1)	1653355	35	29	32	3	12	1	2	1	19	0	0.0292	6.73e-06	0.000259
17	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDK2(1), CUL1(8), E2F1(1), RB1(19), SKP2(1)	1645498	31	28	28	2	10	1	3	1	16	0	0.0189	7.48e-06	0.000271
18	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDK7(3), CDKN1A(18), CHEK1(1), WEE1(2)	1317025	25	22	24	3	5	1	2	0	17	0	0.648	0.000186	0.00637
19	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), RB1(19), SP1(3), SP3(2)	1277699	25	21	23	3	6	1	0	2	16	0	0.177	0.000514	0.0160
20	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(3), IGF1R(5), MYC(1), PPP2CA(1), PRKCA(1), RB1(19), TEP1(4), TERT(1), TNKS(2), TP53(75), XRCC5(1)	5442110	113	73	86	13	27	2	40	9	35	0	0.000137	0.000520	0.0160
21	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), FOS(3), HRAS(6), KLK2(1), MAP2K1(1), MAPK3(3), MAPK8(4), NGFR(3), PIK3CA(26), PIK3R1(2), PLCG1(3), RAF1(1), SOS1(5)	3695372	62	46	46	5	40	3	8	8	3	0	0.000742	0.00239	0.0702
22	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(18), EPOR(1), GRIN1(6), HIF1A(1), JAK2(2), NFKB1(1), NFKBIA(2), RELA(2)	2440672	34	30	33	4	11	0	5	1	17	0	0.253	0.00371	0.104
23	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), ATM(19), BAX(1), BCL2L1(2), CASP3(1), CASP6(1), CASP9(3), PRKCA(1), PTK2(3), STAT1(4), TLN1(2), TP53(75)	5290049	113	79	88	15	36	1	41	9	26	0	0.00436	0.00555	0.149
24	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(6), CREBBP(18), EP300(26), MAP2K1(1), MAP3K7(3), MAPK3(3), SKIL(5), TGFB3(1), TGFBR2(3)	4959453	73	51	72	7	27	2	13	8	23	0	0.00906	0.00832	0.214
25	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(18), EP300(26), MAPK3(3), PELP1(2), SRC(4)	2840672	53	44	52	9	17	2	13	6	15	0	0.103	0.0126	0.310
26	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), ARPC2(3), ARPC4(1), PDGFRA(7), PIK3CA(26), PIK3R1(2), RAC1(1), WASL(1)	2589258	42	37	27	4	30	2	6	3	1	0	0.0171	0.0219	0.518
27	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), RXRA(12)	1050905	14	13	8	2	7	2	3	1	1	0	0.139	0.0425	0.969
28	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(19), BRCA1(4), CDKN1A(18), CHEK1(1), CHEK2(5), GADD45A(1), MAPK8(4), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(6), RAD51(3), RBBP8(2), RELA(2), TP53(75), TP73(2)	5751595	151	93	125	18	50	1	47	10	43	0	0.00870	0.0564	1.000
29	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NFS1(3), THTPA(1), TPK1(2)	1240248	17	14	17	0	12	0	1	1	3	0	0.0192	0.0682	1.000
30	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HBXIP(1), HRAS(6), PTK2B(3), SOS1(5), SRC(4)	1703738	19	16	18	1	12	0	7	0	0	0	0.0304	0.116	1.000
31	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(1), PIK3CA(26), PIK3R1(2)	2473405	37	29	22	4	25	2	5	4	1	0	0.0268	0.122	1.000
32	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(3), ERBB3(14), NRG1(5)	1986130	26	25	22	4	10	2	10	4	0	0	0.160	0.136	1.000
33	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(18), EP300(26), LPL(1), NCOA1(10), NCOA2(4), PPARG(3), RXRA(12)	3561380	74	57	67	11	28	4	17	6	19	0	0.0555	0.175	1.000
34	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREBBP(18), EP300(26), NCOA3(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RARA(3), RXRA(12)	3995136	73	52	66	11	26	6	17	7	17	0	0.0351	0.178	1.000
35	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(6), KLK2(1), NTRK1(4), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), SOS1(5)	3016106	48	41	32	6	33	2	7	5	1	0	0.0175	0.183	1.000
36	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(1), HLA-DRB1(1)	588486	5	5	5	1	0	0	3	1	1	0	0.618	0.185	1.000
37	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(1)	331437	4	4	4	0	2	0	0	0	2	0	0.401	0.186	1.000
38	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(2), CDKN1B(5), CDKN2A(8), E2F1(1), E2F2(1), E2F4(1), PRB1(1)	1724381	23	18	23	4	10	0	4	1	8	0	0.253	0.208	1.000
39	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(2), GBA3(2), LPO(4), MPO(2), PRDX6(4), TPO(9)	1614846	25	21	24	4	10	0	9	3	3	0	0.105	0.217	1.000
40	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(3), CHUK(6), GHR(2), NFKB1(1), NFKBIA(2), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), RELA(2)	2725835	46	35	31	6	30	2	6	2	6	0	0.0523	0.227	1.000
41	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(1), JAK1(3), JAK2(2), PLA2G2A(1), PTPRU(4), REG1A(3), STAT1(4)	2213957	19	18	19	1	11	0	4	2	2	0	0.0269	0.230	1.000
42	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(3), GHR(2), HRAS(6), IGF1R(5), PIK3CA(26), PIK3R1(2), SOD1(2)	2571051	46	40	30	8	28	2	8	5	3	0	0.0792	0.258	1.000
43	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(1), MUSK(2), PIK3CA(26), PIK3R1(2), PTK2(3), PTK2B(3), SRC(4), TERT(1)	3159016	42	36	27	6	30	3	6	2	1	0	0.0156	0.258	1.000
44	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	BCL2L1(2), CASP9(3), CHUK(6), H2AFX(2), HRAS(6), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3CA(26), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(2), RHOA(5)	3688762	64	46	48	9	38	2	9	6	9	0	0.0233	0.259	1.000
45	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(4), GNB1(5), PRKAR1A(1)	1281408	13	11	13	2	6	2	2	1	2	0	0.262	0.291	1.000
46	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12B(2)	572591	5	5	5	0	1	0	2	0	2	0	0.287	0.293	1.000
47	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), FOS(3), HRAS(6), IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), RAF1(1), RASA1(4), SOS1(5)	4786325	67	52	51	9	41	3	9	9	5	0	0.0128	0.300	1.000
48	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB3A(1), RAB5A(1)	819403	6	6	6	0	2	2	0	1	1	0	0.254	0.304	1.000
49	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(1), COQ5(2), COQ6(2), NDUFA12(1), NDUFA13(2)	772198	9	9	9	2	5	1	2	0	1	0	0.530	0.311	1.000
50	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(1), CDKN1A(18), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SP1(3), SP3(2), SYT1(2)	4043967	55	42	54	9	21	3	5	6	20	0	0.231	0.312	1.000
51	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR2(2), JAK1(3), JAK2(2), STAT1(4)	1580572	12	12	12	1	5	1	1	2	3	0	0.176	0.321	1.000
52	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), CDK5R1(1), EGR1(1), HRAS(6), KLK2(1), MAP2K1(1), MAPK3(3), NGFR(3), RAF1(1)	1589377	18	15	17	3	6	1	5	4	2	0	0.193	0.331	1.000
53	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), ANXA1(1), CALM1(1), CALM2(1), GNAS(4), GNB1(5), NFKB1(1), NOS3(6), NR3C1(1), PIK3CA(26), PIK3R1(2), RELA(2), SYT1(2)	3465170	54	44	39	8	36	4	5	5	4	0	0.0603	0.341	1.000
54	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCR4(2), GNAI1(1), GNB1(5), HRAS(6), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3C2G(3), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3), PTK2B(3), RAF1(1), RELA(2)	5321300	63	47	47	5	42	4	8	7	2	0	0.000288	0.351	1.000
55	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), GBA3(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9), TYR(3)	1859703	33	24	32	6	16	0	11	2	4	0	0.0856	0.399	1.000
56	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP19(3), SRP54(1), SRP68(8), SRP72(1), SRP9(1), SRPR(3)	1458879	18	16	18	3	8	0	3	2	5	0	0.336	0.419	1.000
57	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(18), EP300(26), FYN(1), IL2RG(3), IL7(1), IL7R(2), JAK1(3), JAK3(3), LCK(1), PIK3CA(26), PIK3R1(2), PTK2B(3), STAT5B(2)	5396684	91	67	75	15	46	4	15	9	17	0	0.0158	0.431	1.000
58	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(26), PIK3R1(2), PLCB1(4), PLCG1(3), PRKCA(1), VAV1(2)	2480885	38	35	23	6	26	2	3	5	2	0	0.0935	0.435	1.000
59	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), ARHGEF1(6), F2R(2), F2RL3(1), GNA13(5), GNAI1(1), GNB1(5), MAP3K7(3), PIK3CA(26), PIK3R1(2), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2B(3), ROCK1(4)	4988677	68	45	52	8	44	4	5	7	8	0	0.00465	0.444	1.000
60	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	390328	3	3	3	1	2	0	1	0	0	0	0.686	0.471	1.000
61	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SRC(4)	2958697	24	20	24	2	14	1	6	2	1	0	0.0173	0.479	1.000
62	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS7(2), DHRSX(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3)	2911761	26	24	25	3	13	2	5	5	1	0	0.0400	0.489	1.000
63	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	458593	3	3	3	1	1	0	2	0	0	0	0.697	0.534	1.000
64	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GPHN(1), NSF(1), SRC(4)	2294116	24	20	24	4	10	2	8	2	2	0	0.168	0.552	1.000
65	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), SOD1(2)	1509277	16	15	16	4	5	1	6	2	2	0	0.438	0.567	1.000
66	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(2), CASP3(1), CASP8(4), INSR(4), ITCH(5), MAGI1(4), MAGI2(7), RERE(8), WWP1(2), WWP2(2)	4648148	42	33	41	4	22	1	9	5	5	0	0.0134	0.581	1.000
67	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1)	1093542	9	8	9	2	3	0	1	3	2	0	0.403	0.594	1.000
68	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(15), MAP2(5), PPP1CA(4), PPP2CA(1), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1)	3498828	32	23	32	2	21	2	4	2	3	0	0.0368	0.602	1.000
69	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(5), HDC(2)	1161532	10	9	10	2	4	0	2	1	3	0	0.449	0.619	1.000
70	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), GREB1(5), HSPB2(2), MTA1(2), PDZK1(1), TUBA8(1)	2114916	16	14	16	2	4	1	10	0	1	0	0.0793	0.650	1.000
71	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNB1(5), HTR2C(1), PLCB1(4), TUB(1)	1378016	12	10	12	2	5	2	2	2	1	0	0.296	0.658	1.000
72	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS2(2)	1033131	7	6	7	1	5	0	1	0	1	0	0.248	0.681	1.000
73	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SOAT1(4)	2652266	21	19	21	3	13	1	4	2	1	0	0.104	0.687	1.000
74	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1)	977979	6	6	6	0	1	0	5	0	0	0	0.119	0.706	1.000
75	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1), GLUD1(2), GLUD2(3)	879132	7	6	7	2	2	0	3	0	2	0	0.721	0.709	1.000
76	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	220138	1	1	1	1	1	0	0	0	0	0	0.934	0.713	1.000
77	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PDXK(3), PNPO(2), PSAT1(1)	937306	8	8	8	4	3	0	0	1	4	0	0.899	0.723	1.000
78	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), UGDH(2), UGP2(5)	947897	9	9	8	2	6	0	1	1	1	0	0.530	0.733	1.000
79	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3), AOC3(1), ESD(2)	1163257	6	6	6	0	2	0	3	1	0	0	0.155	0.734	1.000
80	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), PER1(3)	1637148	9	9	9	1	2	0	4	1	2	0	0.416	0.763	1.000
81	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), CDC16(1), CDC27(3), CUL1(8), CUL2(4), CUL3(1), FBXW11(1), FBXW7(16), FZR1(2), ITCH(5), SKP1(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(1), UBE2C(1), UBE2D3(1), WWP1(2), WWP2(2)	7749748	69	45	64	6	30	6	13	5	15	0	0.00408	0.776	1.000
82	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(5), ITGB1(1), KLRC4(2), KLRD1(1), LAT(1), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PTK2B(3), RAC1(1), SYK(1), VAV1(2)	3589380	50	42	34	9	31	2	5	5	7	0	0.127	0.783	1.000
83	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(1), FOSL2(3), IFNAR1(1), IFNAR2(1), MAPK8(4), NFKB1(1), RELA(2), TNFSF11(1), TRAF6(1)	2142418	18	15	18	3	8	0	4	1	5	0	0.348	0.787	1.000
84	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI2(3)	820497	4	4	4	0	1	0	2	1	0	0	0.355	0.795	1.000
85	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT5(1), B3GNT5(6), FUT1(2), FUT2(1), FUT3(1)	1391160	12	8	12	1	7	0	5	0	0	0	0.0810	0.803	1.000
86	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1)	4429484	52	37	51	9	21	4	13	3	11	0	0.0532	0.804	1.000
87	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1)	4429484	52	37	51	9	21	4	13	3	11	0	0.0532	0.804	1.000
88	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(1), ITPKA(2), ITPKB(1)	1165072	6	6	6	1	4	0	1	1	0	0	0.434	0.806	1.000
89	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	407844	1	1	1	0	0	0	1	0	0	0	0.762	0.810	1.000
90	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), RAC1(1), WASL(1)	1568083	10	9	10	1	7	1	1	1	0	0	0.262	0.811	1.000
91	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1)	1636994	13	9	13	0	10	1	0	1	1	0	0.0238	0.815	1.000
92	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2)	1088874	8	8	8	2	5	0	2	1	0	0	0.535	0.821	1.000
93	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(4), GNB1(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1)	1861490	18	11	18	2	8	3	4	2	1	0	0.138	0.824	1.000
94	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(1), FUT1(2), FUT2(1), FUT9(1), GCNT2(1), ST8SIA1(1)	1180654	8	7	8	2	2	0	4	2	0	0	0.480	0.828	1.000
95	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	HRAS(6), IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), RAF1(1), SOS1(5)	3672172	52	43	36	9	34	2	6	7	3	0	0.0824	0.829	1.000
96	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(3), EPX(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(1), TPO(9)	2280013	32	24	31	5	18	0	8	3	3	0	0.0408	0.831	1.000
97	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(2), LCMT2(1), METTL2B(1), PCYT1A(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3)	2722705	23	22	22	4	13	2	3	5	0	0	0.187	0.839	1.000
98	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), TYR(3)	908525	6	6	6	2	3	0	3	0	0	0	0.653	0.847	1.000
99	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(18), DFFA(4), GZMA(4), HMGB2(4), PRF1(4)	2040378	35	30	34	9	15	0	11	2	7	0	0.401	0.884	1.000
100	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CTH(2), MUT(1)	946870	3	3	3	0	1	1	1	0	0	0	0.474	0.887	1.000
101	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(4), FADD(1), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF2(2)	1622003	15	14	15	3	8	0	4	2	1	0	0.328	0.887	1.000
102	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2)	1032374	11	11	11	4	5	0	3	2	1	0	0.670	0.889	1.000
103	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2)	1345812	9	9	9	2	3	0	4	1	1	0	0.547	0.891	1.000
104	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(2), MBTPS1(4), SCAP(3), SREBF1(4), SREBF2(2)	2309312	16	15	16	3	7	0	5	2	2	0	0.235	0.892	1.000
105	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(1), HADHA(3)	1044366	4	4	4	1	3	0	0	0	1	0	0.753	0.895	1.000
106	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), FDXR(3), SHMT1(1)	3098582	33	26	33	6	15	3	6	5	4	0	0.0960	0.898	1.000
107	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(3), MAP2K1(1), MAP3K1(3), MAPK14(1), NCOR2(10), RARA(3), RXRA(12)	3347403	37	35	31	8	14	2	13	4	4	0	0.229	0.899	1.000
108	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(2), LPL(1)	1029629	8	8	8	3	4	0	2	0	2	0	0.772	0.902	1.000
109	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), FMOD(1), KERA(2)	697527	4	4	4	2	2	0	2	0	0	0	0.808	0.903	1.000
110	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RELA(2)	1590882	10	9	10	2	4	0	2	3	1	0	0.463	0.906	1.000
111	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(1), EHHADH(1), HADHA(3), HADHB(2), SDS(1)	1617062	10	8	10	1	9	0	0	0	1	0	0.231	0.906	1.000
112	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), NAT1(2), XDH(6)	1543255	19	19	19	5	8	0	4	4	3	0	0.338	0.907	1.000
113	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3E(1), CD8A(2), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5)	2069086	17	16	17	4	7	1	4	2	3	0	0.283	0.917	1.000
114	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1)	2910134	30	24	30	6	12	3	6	5	4	0	0.163	0.918	1.000
115	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1)	2910134	30	24	30	6	12	3	6	5	4	0	0.163	0.918	1.000
116	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1)	2910134	30	24	30	6	12	3	6	5	4	0	0.163	0.918	1.000
117	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(4), CFLAR(1)	748523	6	6	6	2	3	0	1	1	1	0	0.694	0.918	1.000
118	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), DFFA(4), HMGB1(1), HMGB2(4), TOP2A(7), TOP2B(2)	1704993	19	18	19	4	14	0	2	1	2	0	0.597	0.919	1.000
119	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), FADD(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(1), MCL1(1), MYC(1), NFKB1(1), NFKBIA(2), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFSF10(2), TP53(75), TRADD(1), TRAF2(2)	7236114	123	78	98	22	39	2	49	9	24	0	0.0179	0.924	1.000
120	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1)	653008	1	1	1	2	0	0	0	0	1	0	1.000	0.924	1.000
121	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1)	1074281	5	4	5	1	3	1	1	0	0	0	0.589	0.924	1.000
122	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), JUNB(4), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(4), NFATC2(6), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	2347929	26	18	26	5	9	3	6	3	5	0	0.164	0.926	1.000
123	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), SNAP25(1)	629498	2	2	2	0	2	0	0	0	0	0	0.470	0.928	1.000
124	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(3), EPX(2), LPO(4), MPO(2), MTHFR(1), PRDX6(4), SHMT1(1), TPO(9)	2243863	26	21	25	5	13	0	8	3	2	0	0.134	0.939	1.000
125	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT3(1), BPNT1(2), MAPK3(3), PIK3CA(26), PIK3CD(3), PTEN(5), PTK2B(3), RBL2(3), SOS1(5)	3941926	51	41	36	9	39	2	3	4	3	0	0.0975	0.941	1.000
126	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3)	1793052	13	10	13	3	6	0	5	2	0	0	0.289	0.947	1.000
127	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3)	1793052	13	10	13	3	6	0	5	2	0	0	0.289	0.947	1.000
128	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(1), SHMT1(1)	794800	4	4	4	3	1	0	1	0	2	0	0.947	0.949	1.000
129	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2)	756956	2	2	2	1	2	0	0	0	0	0	0.792	0.956	1.000
130	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(1), GRM1(7), PLCB1(4), PPP1CA(4), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	3096119	30	22	30	6	10	2	7	6	5	0	0.229	0.959	1.000
131	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(6), CREBBP(18), EP300(26), FADD(1), IKBKB(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF6(1)	4322882	67	50	66	13	24	2	15	6	20	0	0.143	0.960	1.000
132	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3E(1), HLA-A(5), ICAM1(3), ITGAL(2), ITGB2(3), PRF1(4)	1692530	19	18	18	6	7	0	6	2	4	0	0.486	0.965	1.000
133	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NFKB1(1), PIK3CA(26), PIK3R1(2), RB1(19), RELA(2), SP1(3)	3746001	63	48	46	11	30	4	4	6	19	0	0.130	0.967	1.000
134	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(3), CAP1(5), CCNB1(1), GNAI1(1), GNAS(4), GNB1(5), HRAS(6), MAPK3(3), MYT1(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RPS6KA1(1), SRC(4)	3990128	46	33	45	8	20	4	13	5	4	0	0.0619	0.968	1.000
135	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(5), FECH(1), PPOX(4), UROD(1), UROS(2)	1462080	14	13	14	6	6	0	3	1	4	0	0.865	0.968	1.000
136	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), FOS(3), HRAS(6), INSR(4), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), RAF1(1), RASA1(4), SLC2A4(1), SOS1(5)	4918083	67	51	51	11	43	3	9	8	4	0	0.0329	0.968	1.000
137	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1), HADHA(3), SDS(1)	936834	5	5	5	2	5	0	0	0	0	0	0.695	0.969	1.000
138	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), FOS(3), HRAS(6), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4)	6743397	81	61	65	11	48	4	14	10	5	0	0.00485	0.970	1.000
139	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10RA(4), IL10RB(3), IL1A(1), IL6(2), JAK1(3), STAT1(4)	2364136	18	15	18	4	9	0	0	3	6	0	0.243	0.971	1.000
140	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(3), GPR171(1), GPR39(2), GPR45(3), GPR65(1), GPR68(2), GPR75(6), GPR81(3)	1894848	22	17	22	7	10	0	5	3	4	0	0.327	0.972	1.000
141	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(5), FECH(1), GATA1(4), UROD(1), UROS(2)	1509673	14	11	14	6	6	1	2	1	4	0	0.851	0.972	1.000
142	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(1), GCDH(2), HADHA(3), SDS(1)	1510121	8	7	8	2	7	0	0	0	1	0	0.587	0.972	1.000
143	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(3), KEAP1(5), MAFF(1), MAFK(1), MAPK14(1), MAPK8(4), NFE2L2(12), PRKCA(1)	1716321	28	19	25	7	13	1	6	5	3	0	0.436	0.972	1.000
144	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(3), HSD3B1(2), HSD3B2(3)	1337035	10	8	10	3	6	0	4	0	0	0	0.352	0.973	1.000
145	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), ADRB2(2), CFTR(2), GNAS(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	2527486	18	15	18	4	7	1	5	2	3	0	0.375	0.974	1.000
146	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), ASAH1(2), GNAI1(1), GNB1(5), ITGAV(3), ITGB3(2), MAPK3(3), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLCB1(4), PRKCA(1), PTK2(3), RAC1(1), SMPD1(3), SMPD2(2), SRC(4)	5308686	72	55	57	13	43	4	12	9	4	0	0.0390	0.975	1.000
147	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(3), IL1A(1), IL6(2), KITLG(2), TGFB3(1)	1611076	10	10	10	3	7	0	0	1	2	0	0.591	0.976	1.000
148	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(3)	593573	3	3	3	2	3	0	0	0	0	0	0.848	0.980	1.000
149	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(1), IL12B(2), IL16(2), IL1A(1), IL6(2), IL8(1)	1910836	9	9	9	2	5	0	3	0	1	0	0.377	0.981	1.000
150	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(19), ATR(3), BRCA1(4), CCNB1(1), CDC25A(1), CDKN1A(18), CDKN2D(1), CHEK1(1), CHEK2(5), EP300(26), GADD45A(1), MYT1(3), PRKDC(10), RPS6KA1(1), TP53(75), WEE1(2), YWHAQ(1)	8079041	172	92	146	27	53	6	51	13	49	0	0.0474	0.981	1.000
151	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1)	611494	1	1	1	0	1	0	0	0	0	0	0.747	0.984	1.000
152	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(1), GRIA2(3), JUND(1), PPP1R1B(1)	720820	7	7	7	3	5	0	0	1	1	0	0.838	0.984	1.000
153	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGAP3(3), ARFGEF2(4), CLTB(1), COPA(5), GBF1(8), GPLD1(4)	3142494	27	21	27	5	18	2	4	1	2	0	0.153	0.985	1.000
154	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), FDPS(1), HMGCR(1), HMGCS1(1), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1)	2550982	15	12	15	3	9	2	1	3	0	0	0.308	0.985	1.000
155	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), BAX(1), BCL2L1(2), CSF2RB(1), IGF1R(5), IL3RA(3), KIT(3), KITLG(2), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	4244839	55	41	40	11	29	4	7	6	9	0	0.0695	0.985	1.000
156	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(2), GGT1(1), SHMT1(1)	1057334	7	7	7	5	2	0	2	1	2	0	0.961	0.987	1.000
157	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), HPD(2), LPO(4), MAOA(1), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9)	4244493	42	32	41	7	23	0	12	3	4	0	0.0165	0.987	1.000
158	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(3), CSNK2A1(4), FOS(3), HRAS(6), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(2), JAK3(3), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5)	4619426	40	32	39	6	21	1	6	8	4	0	0.0586	0.988	1.000
159	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(4), GNB1(5), PPP2CA(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	2974081	27	19	27	5	10	4	8	1	4	0	0.230	0.989	1.000
160	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(3), CPS1(4), GLS(1), GLUD1(2)	1500433	10	6	10	3	7	0	2	0	1	0	0.606	0.989	1.000
161	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(5), GGT1(1)	1112933	8	8	8	8	4	0	2	0	2	0	0.992	0.990	1.000
162	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGT(1), AGTR2(1), KNG1(1), NOS3(6), REN(2)	1919184	18	17	17	5	11	0	6	0	1	0	0.271	0.991	1.000
163	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(13), ACACB(5), FASN(2), MCAT(1), OXSM(2)	3092336	23	22	22	5	16	1	1	3	2	0	0.217	0.991	1.000
164	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), FOS(3), HRAS(6), IL2RA(1), IL2RB(2), IL2RG(3), JAK1(3), JAK3(3), LCK(1), MAP2K1(1), MAPK3(3), MAPK8(4), RAF1(1), SOS1(5), STAT5B(2), SYK(1)	4508007	43	34	42	9	20	1	11	8	3	0	0.130	0.992	1.000
165	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAPK3(3), MPL(1), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4), STAT5B(2), THPO(1)	5788178	69	53	53	10	45	4	8	8	4	0	0.0163	0.992	1.000
166	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(3), PRKCA(1), PTK2B(3)	1297367	8	8	8	3	6	0	1	1	0	0	0.614	0.992	1.000
167	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), UGDH(2)	744595	4	4	4	2	2	0	1	1	0	0	0.861	0.993	1.000
168	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), P2RY1(1), P2RY2(1)	1152233	3	3	3	2	2	0	0	1	0	0	0.753	0.994	1.000
169	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), APOA2(1), CD36(1), CITED2(1), CPT1B(2), CREBBP(18), DUT(1), EHHADH(1), EP300(26), HSD17B4(3), HSPA1A(2), LPL(1), MAPK3(3), ME1(2), MRPL11(1), MYC(1), NCOA1(10), NCOR1(13), NCOR2(10), NFKBIA(2), NR2F1(2), NRIP1(4), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PTGS2(2), RB1(19), RELA(2), RXRA(12), SP1(3), STAT5B(2)	12210636	182	86	158	29	78	9	31	19	45	0	0.00105	0.994	1.000
170	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(4), EGFR(3), FOS(3), HRAS(6), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4)	7238534	81	60	65	12	49	4	13	10	5	0	0.0106	0.994	1.000
171	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(1), FUT8(5), ST3GAL1(1)	1522294	8	8	8	3	4	0	1	3	0	0	0.698	0.994	1.000
172	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLD2(3), POLE(6), POLQ(8)	3244322	20	17	20	4	12	0	3	1	4	0	0.250	0.995	1.000
173	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(3), FADS2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1)	1963243	13	12	13	4	5	0	3	3	2	0	0.567	0.995	1.000
174	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(1), ACOX3(3), ELOVL5(1), ELOVL6(1), FADS1(2), FADS2(1), FASN(2), HADHA(3), SCD(1)	2805082	16	14	16	4	10	0	3	1	2	0	0.280	0.996	1.000
175	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), HLA-DRA(1), HLA-DRB1(1)	767428	3	3	3	2	1	0	2	0	0	0	0.866	0.996	1.000
176	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1)	3112564	22	14	22	4	12	0	5	4	1	0	0.149	0.996	1.000
177	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(10), RANGAP1(2)	1625665	13	11	13	3	6	2	2	1	2	0	0.717	0.996	1.000
178	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(6), MAPK3(3), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(4), PIK3CA(26), PIK3R1(2), PLCG1(3), RPS6KA1(1)	3666641	51	43	35	10	32	2	12	4	1	0	0.0695	0.996	1.000
179	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1)	2074499	12	12	12	4	6	0	4	1	1	0	0.570	0.996	1.000
180	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1)	1950855	12	8	12	3	8	1	1	0	2	0	0.560	0.997	1.000
181	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA4(2), APOC1(1), CETP(2), CYP7A1(4), DGAT1(1), HMGCR(1), LCAT(1), LDLR(2), LIPC(5), LPL(1), LRP1(12), SCARB1(1), SOAT1(4)	5300968	43	31	43	8	25	1	8	2	7	0	0.0530	0.997	1.000
182	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F13A1(2), F2R(2), FGA(7), FGB(1), FGG(3), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2)	2585938	23	19	23	5	10	0	8	1	4	0	0.356	0.997	1.000
183	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(3), NRG3(3), PRKCA(1), PSEN1(5)	1736379	13	13	13	4	6	1	3	1	2	0	0.698	0.997	1.000
184	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(2), IMPDH1(1), MTHFD2(2), POLD1(3), RRM1(1), SRM(2)	2427855	12	10	12	3	4	1	6	0	1	0	0.519	0.997	1.000
185	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(6), FCGR2B(1), HLA-DRA(1), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5)	2918637	25	24	25	6	9	2	8	3	3	0	0.342	0.997	1.000
186	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDPS(1), HMGCR(1), LSS(3), PMVK(1), SC5DL(1), VKORC1(1)	2139206	8	8	8	2	5	1	1	1	0	0	0.499	0.997	1.000
187	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FHL5(1), FSHR(1), GNAS(4), XPO1(3)	1853617	12	9	12	5	6	0	1	2	3	0	0.855	0.998	1.000
188	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(1), PAH(3), YARS(3)	1606332	10	10	10	6	2	1	3	1	3	0	0.934	0.998	1.000
189	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1)	1954235	11	11	11	4	6	0	3	1	1	0	0.625	0.998	1.000
190	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(2), CSF1(2), IL6(2), IL7(1), IL8(1)	1182748	9	9	9	4	6	1	2	0	0	0	0.679	0.998	1.000
191	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB4(3), ABCC1(8), ABCC3(8), GSTP1(2)	2756497	27	22	27	8	15	2	5	4	1	0	0.319	0.998	1.000
192	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(1), PPARG(3), RXRA(12)	1116810	17	17	11	7	9	2	4	1	1	0	0.769	0.998	1.000
193	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(3), MST1R(5)	1265983	11	10	11	9	5	1	3	1	1	0	0.973	0.999	1.000
194	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(1), DAB1(4), FYN(1), RELN(13), VLDLR(2)	2709901	22	18	22	5	10	2	5	2	3	0	0.458	0.999	1.000
195	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH2(2), HMGCS1(1), OXCT2(1)	1392249	5	5	5	4	0	1	2	1	1	0	0.981	0.999	1.000
196	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(1), HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(3)	1559341	11	10	11	4	8	0	2	1	0	0	0.666	0.999	1.000
197	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3E(1), CD4(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5)	2169711	16	15	16	5	8	0	3	2	3	0	0.460	0.999	1.000
198	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(8), CASP1(2), CASP3(1), CASP8(4), CASP9(3), PRF1(4)	2492970	23	21	23	9	9	0	6	3	5	0	0.866	0.999	1.000
199	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2)	1544046	7	7	7	6	3	0	1	1	2	0	0.960	0.999	1.000
200	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2)	1544046	7	7	7	6	3	0	1	1	2	0	0.960	0.999	1.000
201	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(2), CD3E(1), CD4(1), CD58(1), CD8A(2), IL6(2), IL8(1), KITLG(2)	1198088	13	12	13	7	7	1	2	1	2	0	0.881	0.999	1.000
202	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(19), ATR(3), BRCA1(4), BRCA2(17), CHEK1(1), CHEK2(5), FANCA(5), FANCC(2), FANCD2(10), FANCE(2), FANCF(2), FANCG(2), HUS1(1), MRE11A(2), RAD1(1), RAD17(1), RAD50(6), RAD51(3), TP53(75)	8504536	161	88	136	24	63	5	45	13	35	0	0.0244	0.999	1.000
203	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), FPGS(1), GCH1(1)	1247548	5	5	5	5	3	0	1	0	1	0	0.955	0.999	1.000
204	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(2), SNCAIP(3), UBE2L6(1)	1240898	8	7	8	8	3	2	1	1	1	0	0.996	0.999	1.000
205	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(4), AASS(3), KARS(3)	1340895	10	10	10	5	5	1	1	2	1	0	0.934	0.999	1.000
206	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), IFNG(1), IL2RA(1), TGFB3(1), TGFBR2(3), TGFBR3(7), TOB1(4)	2050270	18	18	18	5	12	0	4	0	2	0	0.526	0.999	1.000
207	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C5(3), C8A(2), C9(5)	2415790	15	14	15	4	6	1	6	1	1	0	0.568	0.999	1.000
208	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(3), TRAF2(2)	4338292	34	30	34	7	16	2	8	2	6	0	0.233	0.999	1.000
209	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAX(1), BCL10(1), BCL2L1(2), CASP8AP2(7), CASP9(3)	2075485	15	14	15	5	7	0	3	2	3	0	0.813	0.999	1.000
210	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH3A1(2), ALDH9A1(2), UGDH(2)	1647021	6	6	6	5	3	0	0	1	2	0	0.949	0.999	1.000
211	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(3), MAPT(5), PPP2CA(1)	1789183	14	11	14	7	6	0	3	2	3	0	0.943	0.999	1.000
212	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2)	1257884	7	7	7	4	4	1	1	1	0	0	0.765	1.000	1.000
213	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2)	1257884	7	7	7	4	4	1	1	1	0	0	0.765	1.000	1.000
214	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(3), MAPK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	2490456	13	10	13	4	5	1	4	1	2	0	0.573	1.000	1.000
215	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(1), FOS(3), FYN(1), MAPK14(1)	1430515	7	6	7	3	3	0	1	1	2	0	0.815	1.000	1.000
216	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(5), ZAP70(1)	1735611	12	9	12	5	6	0	3	1	2	0	0.771	1.000	1.000
217	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTR(3)	3367042	13	12	13	3	7	1	2	1	2	0	0.380	1.000	1.000
218	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(4), FURIN(2), NOTCH1(5), PSEN1(5)	1780063	17	16	17	8	8	1	5	1	2	0	0.883	1.000	1.000
219	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(6), MMP14(1), MMP2(2), MMP9(3), RECK(1)	1457135	13	12	12	8	3	2	7	0	1	0	0.950	1.000	1.000
220	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), GNAS(4), GNB1(5), HRAS(6), LIMK1(2), MAP2K1(1), MAPK3(3), MYL2(2), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2(3), RAF1(1), ROCK2(6)	4842671	47	34	46	9	23	2	8	11	3	0	0.208	1.000	1.000
221	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), FARSB(2), PAH(3), YARS(3), YARS2(1)	1680288	10	10	10	4	3	1	3	1	2	0	0.744	1.000	1.000
222	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(1), IL8(1), NFKB1(1), NOX1(1), RELA(2), SOD1(2), XDH(6)	1918966	16	14	16	7	7	0	6	0	3	0	0.730	1.000	1.000
223	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), DFFA(4)	2601865	18	17	18	6	8	0	5	1	4	0	0.765	1.000	1.000
224	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(2), BRAF(1), CREB5(5), RAF1(1), SNX13(4), SRC(4), TERF2IP(2)	2151152	21	17	21	6	10	1	3	3	4	0	0.593	1.000	1.000
225	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(3), CDC25A(1), CDK7(3), MNAT1(1), XPO1(3)	1670908	12	9	12	5	7	1	1	1	2	0	0.858	1.000	1.000
226	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1)	3185924	17	16	17	4	11	1	3	1	1	0	0.376	1.000	1.000
227	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNAR2(1), JAK1(3), STAT1(4), STAT2(2), TYK2(2)	2088938	13	11	13	9	5	0	2	2	4	0	0.957	1.000	1.000
228	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(2), DHCR24(2), FDPS(1), GGCX(2), HMGCR(1), IDI2(3), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1), TM7SF2(1), VKORC1(1)	3729681	25	19	25	6	14	2	4	5	0	0	0.267	1.000	1.000
229	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(4), FADD(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFKB1(1), NSMAF(4), RAF1(1), RELA(2), RIPK1(2), SMPD1(3), TRADD(1), TRAF2(2)	3971477	34	29	34	8	15	1	6	6	6	0	0.319	1.000	1.000
230	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(1), DPM1(1), FUT8(5), MAN1A1(3), MAN1B1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), ST6GAL1(1)	3840331	24	17	24	5	13	0	4	7	0	0	0.224	1.000	1.000
231	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(1), CASP3(1), CASP8(4), CASP9(3), DFFA(4), PRF1(4), SCAP(3), SREBF1(4), SREBF2(2)	3530946	27	25	27	7	11	0	10	3	3	0	0.416	1.000	1.000
232	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(3), HRAS(6), MAP2K1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RAF1(1), RELA(2)	3006215	25	22	24	7	9	1	7	6	2	0	0.474	1.000	1.000
233	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(2), EIF2S3(2), EIF4E(1), EIF4EBP1(1), IGF1R(5), INPPL1(2), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3)	3810509	52	40	37	11	32	2	9	4	5	0	0.206	1.000	1.000
234	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	CDKN1B(5), ITGB1(1), MAPK3(3), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PTEN(5), PTK2(3), SOS1(5)	3734241	52	40	37	10	38	2	3	3	6	0	0.244	1.000	1.000
235	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(8), ARHGEF1(6), GNA13(5), GNB1(5), MYL2(2), MYLK(5), PLCB1(4), PPP1R12B(2), PRKCA(1), ROCK1(4)	3997666	42	27	41	9	24	2	3	8	5	0	0.307	1.000	1.000
236	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACSL1(1), CPT1A(2), EHHADH(1), HADHA(3), SCP2(2)	3254546	9	9	9	1	9	0	0	0	0	0	0.234	1.000	1.000
237	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2A(1), UBE2B(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE2J1(4), UBE2L6(1), UBE2N(2), UBE2S(1), UBE3A(5)	2030812	18	14	18	8	9	3	3	1	2	0	0.903	1.000	1.000
238	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(2), PSMB9(1)	1690643	11	11	11	5	7	0	2	1	1	0	0.857	1.000	1.000
239	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), FBL(1), MAPK14(1), NCL(1)	1735727	7	7	7	7	5	0	1	0	1	0	0.989	1.000	1.000
240	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(1), RELA(2), TNFRSF13C(1), TNFSF13B(3), TRAF2(2), TRAF6(1)	2807196	23	18	23	8	13	0	3	2	5	0	0.722	1.000	1.000
241	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(2), FH(3), IDH1(3), MDH1(1)	1720729	10	10	10	5	5	0	2	2	1	0	0.861	1.000	1.000
242	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2)	2556311	12	12	12	4	7	0	2	1	2	0	0.559	1.000	1.000
243	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), SYT1(2)	4942895	54	37	54	12	23	5	12	9	5	0	0.129	1.000	1.000
244	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CALM1(1), CALM2(1), FOS(3), GNAI1(1), GNAS(4), GNB1(5), HRAS(6), MAP2K1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(2), SYT1(2)	6756300	67	44	66	11	31	6	13	9	8	0	0.0371	1.000	1.000
245	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(1), DUSP14(2), EIF4E(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), JUND(1), MYOG(1), NR4A3(1), WDR1(2)	2067085	17	15	17	6	9	3	3	0	2	0	0.716	1.000	1.000
246	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CDK5R1(1), CHN1(3), LIMK1(2), MAP3K1(3), MYL2(2), MYLK(5), NCF2(4), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(1), TRIO(13), VAV1(2)	6754403	78	60	63	13	46	3	14	7	8	0	0.0309	1.000	1.000
247	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(3), PTPRU(4), REG1A(3), STAT1(4), STAT2(2), TYK2(2)	2418601	19	15	19	9	8	0	5	2	4	0	0.771	1.000	1.000
248	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(3), HRAS(6), IL3RA(3), JAK2(2), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5), STAT5B(2)	3418311	27	24	26	7	15	1	5	3	3	0	0.366	1.000	1.000
249	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS2(2), ILVBL(1), LARS(1), LARS2(1), PDHA2(2), VARS(3), VARS2(4)	3595155	16	16	16	4	10	1	5	0	0	0	0.457	1.000	1.000
250	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(6), IFNG(1), IKBKB(4), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), TNFRSF9(2), TRAF2(2)	3720840	33	27	33	9	15	0	9	2	7	0	0.550	1.000	1.000
251	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(8), PSMC3(2), PSMD1(4), PSMD11(3), PSMD12(2), PSMD6(1)	3091312	28	23	28	9	21	0	2	1	4	0	0.671	1.000	1.000
252	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCR5(2), CXCR4(2), FOS(3), MAPK14(1), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), SYT1(2)	2661183	23	21	23	9	10	0	4	5	4	0	0.784	1.000	1.000
253	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS1(1), DHRS7(2), DHRSX(3), HSD3B7(1), PON1(1), PON2(1), RDH13(1)	1745635	11	10	11	7	6	0	4	0	1	0	0.888	1.000	1.000
254	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX5(2), DPEP1(2), GGT1(1), LTA4H(1), PLA2G2A(1), PLA2G6(1), PTGIS(1), PTGS2(2), TBXAS1(3)	2910685	16	13	16	9	7	0	3	2	4	0	0.877	1.000	1.000
255	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(4), PIR(1), RAC1(1), WASF2(3), WASF3(1), WASL(1)	2952250	25	20	25	6	16	1	5	2	1	0	0.459	1.000	1.000
256	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CSF1(2), IL1B(1), IL6R(1), SPN(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3)	2560010	22	17	21	6	12	0	8	1	1	0	0.351	1.000	1.000
257	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(4), GLI3(10), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SMO(2)	3224307	24	19	24	9	8	1	11	0	4	0	0.721	1.000	1.000
258	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), TNFAIP3(2), TRAF6(1)	3505989	27	23	27	8	14	1	5	1	6	0	0.621	1.000	1.000
259	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), IDS(1), LCT(4), NAGLU(1)	2785263	17	17	17	5	10	1	2	3	1	0	0.470	1.000	1.000
260	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(3), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SRM(2), UPB1(3)	5220751	33	27	33	7	15	1	9	5	3	0	0.190	1.000	1.000
261	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(3), ACY3(3), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CARM1(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), LCMT2(1), MAOA(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), UROC1(1), WBSCR22(3)	7659402	47	42	46	9	22	2	12	7	4	0	0.0621	1.000	1.000
262	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), CAMK2B(2), CAMK2D(1), CAMK2G(3), GNAS(4), HRAS(6), MAPK14(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5)	5636847	69	48	53	14	44	3	12	5	5	0	0.0946	1.000	1.000
263	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), SDS(1)	2349921	12	11	12	6	8	0	1	1	2	0	0.794	1.000	1.000
264	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), GLB1(2), HEXA(1), HEXB(2), LCT(4), SLC33A1(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1)	3182798	27	25	27	9	15	1	4	5	2	0	0.483	1.000	1.000
265	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2)	2474259	15	14	15	7	5	0	7	1	2	0	0.874	1.000	1.000
266	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(2), GGT1(1), MAT1A(2), SCLY(1)	2392384	6	6	6	8	2	1	1	0	2	0	0.996	1.000	1.000
267	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(2), AGT(1), AGTR2(1), ANPEP(3), CPA3(3), CTSG(3), ENPEP(3), LNPEP(1), MME(4), REN(2), THOP1(3)	4093353	33	27	32	9	19	0	6	3	5	0	0.326	1.000	1.000
268	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(6), CREBBP(18), EP300(26), IKBKB(4), IL1B(1), IL8(1), MAP2K3(2), MAP3K14(2), MAP3K7(3), MAPK11(2), MAPK14(1), MYD88(1), NFKB1(1), NFKBIA(2), NR3C1(1), RELA(2), TGFBR2(3), TLR2(2)	5729563	78	52	77	17	30	3	16	5	24	0	0.254	1.000	1.000
269	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(3), ACTN3(2), CSK(4), CTNNA1(1), CTNNA2(2), CTNNB1(4), PTK2(3), SRC(4), VCL(1)	3716291	26	23	26	6	17	2	5	1	1	0	0.293	1.000	1.000
270	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), XYLB(5)	5221356	36	26	34	8	20	3	5	5	3	0	0.251	1.000	1.000
271	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(2), AFMID(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2)	2592482	17	16	17	7	6	1	7	1	2	0	0.802	1.000	1.000
272	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2)	2026709	9	9	9	8	5	0	2	1	1	0	0.988	1.000	1.000
273	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2)	2026709	9	9	9	8	5	0	2	1	1	0	0.988	1.000	1.000
274	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2)	2597919	9	8	9	3	6	0	1	2	0	0	0.668	1.000	1.000
275	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(13), CPT1A(2), LEPR(4), PRKAA2(4), PRKAB2(1), PRKAG1(2)	2805492	26	22	26	9	15	1	5	2	3	0	0.761	1.000	1.000
276	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), ADRB2(2), GNAS(4), PLCE1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1)	2857621	18	15	18	8	7	1	6	1	3	0	0.870	1.000	1.000
277	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(2)	2293187	13	12	13	5	10	1	0	1	1	0	0.787	1.000	1.000
278	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(2), EIF2B5(2), EIF2S3(2), PPP1CA(4)	2232566	13	11	13	6	6	0	3	3	1	0	0.906	1.000	1.000
279	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(6), EGF(4), EGFR(3), HGS(2), RAB5A(1), TFRC(2)	2484220	18	17	18	5	11	0	4	2	1	0	0.617	1.000	1.000
280	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), NPAS2(1), NR1D1(3), PER1(3), PER2(1), PER3(3)	3289910	17	15	17	7	6	0	7	1	3	0	0.867	1.000	1.000
281	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), CHST2(1), CHST4(2), CHST6(1), FUT8(5), ST3GAL1(1)	2409373	15	15	14	9	8	0	2	4	1	0	0.919	1.000	1.000
282	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IL12B(2), IL1A(1), IL6(2), IL7(1), IL8(1), TGFB3(1)	2576046	14	14	14	5	8	0	5	0	1	0	0.513	1.000	1.000
283	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL2RA(1), IL4R(1)	2447735	14	14	14	5	4	1	8	0	1	0	0.703	1.000	1.000
284	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1)	3458365	17	14	17	8	7	1	4	2	3	0	0.880	1.000	1.000
285	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), UBE2A(1), UBE3A(5)	2488114	16	15	16	6	11	0	2	2	1	0	0.763	1.000	1.000
286	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(2), ASAH1(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SMPD1(3), SMPD2(2), SPTLC1(3), SPTLC2(3), UGCG(1)	4658004	43	34	43	11	24	1	8	4	6	0	0.270	1.000	1.000
287	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL2RG(3), IL4R(1), IRS1(3), JAK1(3), JAK3(3), STAT6(3)	2864720	16	13	16	8	9	0	2	3	2	0	0.879	1.000	1.000
288	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1)	3931006	19	18	19	5	12	1	4	1	1	0	0.390	1.000	1.000
289	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(3), CALM1(1), CALM2(1), FCER1A(2), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PAK2(1), PIK3CA(26), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2)	8314441	98	66	82	17	56	6	15	14	7	0	0.0308	1.000	1.000
290	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(10), NCOA2(4), NCOA3(5), NCOR2(10), RARA(3), RXRA(12)	4825218	49	41	43	10	24	2	13	3	7	0	0.188	1.000	1.000
291	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5)	3370749	19	17	19	6	7	1	8	1	2	0	0.619	1.000	1.000
292	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2R(2), F5(9), FGA(7), FGB(1), FGG(3), PROS1(4), SERPINC1(1)	3165429	28	24	28	8	19	1	7	0	1	0	0.551	1.000	1.000
293	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(4), MPI(2), PGM1(2), PYGL(1), PYGM(4), TREH(1)	2587327	17	15	17	8	11	0	3	2	1	0	0.745	1.000	1.000
294	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTFMT(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1)	3662369	18	15	18	9	8	1	4	2	3	0	0.912	1.000	1.000
295	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), NAGLU(1), SPAM1(1)	3957115	25	23	25	8	15	1	3	4	2	0	0.481	1.000	1.000
296	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	DLD(2), DUSP10(3), DUSP4(1), DUSP8(3), GAB1(2), GADD45A(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK10(1), MAPK7(2), MAPK8(4), MAPK9(5), MYEF2(2), NFATC3(2), NR2C2(2), PAPPA(4), TP53(75), TRAF6(1), ZAK(1)	9719875	140	83	115	27	47	1	53	10	29	0	0.0522	1.000	1.000
297	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GCNT1(1), ST3GAL1(1), WBSCR17(3)	2788109	15	14	15	7	10	1	2	1	1	0	0.832	1.000	1.000
298	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C8B(2), C9(5), MASP1(3)	4009297	24	21	24	7	10	1	9	2	2	0	0.521	1.000	1.000
299	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2)	3195593	18	16	18	5	8	0	6	2	2	0	0.611	1.000	1.000
300	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5), MASP1(3), MASP2(3)	4109416	25	21	25	8	9	1	9	3	3	0	0.616	1.000	1.000
301	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(1), CP(1), EPRS(5), FECH(1), GUSB(1), HCCS(1), HMOX2(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2), UROD(1), UROS(2)	5282309	31	23	31	9	14	2	7	2	6	0	0.531	1.000	1.000
302	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF1(1), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), ELAVL1(2), FLT1(1), FLT4(1), HIF1A(1), HRAS(6), KDR(9), NOS3(6), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3)	6579220	73	49	57	15	43	3	12	6	9	0	0.0798	1.000	1.000
303	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(3), AOC3(1), DDHD1(2), ESCO1(1), ESCO2(1), LIPA(1), MYST3(5), MYST4(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(4)	4883353	26	22	25	6	14	0	6	4	2	0	0.393	1.000	1.000
304	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(19), ATR(3), BAI1(1), BAX(1), CASP3(1), CASP8(4), CASP9(3), CCNB1(1), CCNB3(5), CCND1(1), CCND3(5), CCNE2(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN2A(8), CHEK1(1), CHEK2(5), DDB2(4), GADD45A(1), GTSE1(2), LRDD(6), PERP(1), PTEN(5), RCHY1(1), RFWD2(2), RRM2(2), SERPINB5(1), SERPINE1(2), SESN1(2), SESN3(2), SFN(1), STEAP3(1), TP53(75), TP53I3(2), TP73(2), TSC2(2), ZMAT3(1)	12590250	197	95	171	32	73	2	57	12	53	0	0.00572	1.000	1.000
305	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(4), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), FN3K(2), GCDH(2), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1)	5016957	32	28	32	8	20	0	7	2	3	0	0.433	1.000	1.000
306	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), ODC1(1), PYCR1(3)	3394201	18	13	18	7	12	0	3	1	2	0	0.700	1.000	1.000
307	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), BST1(1), C9orf95(1), CD38(1), ENPP1(2), NADK(2), NADSYN1(3), NNMT(1), NNT(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), NUDT12(1), QPRT(2)	4160390	30	23	30	8	17	3	8	2	0	0	0.435	1.000	1.000
308	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(6), EGR2(1), EGR3(1), MAP3K1(3), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), SYT1(2), VIPR2(4)	5399164	55	39	55	13	24	5	10	4	12	0	0.270	1.000	1.000
309	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), MAOA(1)	4712282	26	24	26	8	11	0	8	3	4	0	0.466	1.000	1.000
310	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(2), HRAS(6), INSR(4), IRS1(3), JAK2(2), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RPS6KA1(1), SLC2A4(1), SOS1(5), STAT5B(2)	6398577	63	48	47	15	44	2	8	7	2	0	0.167	1.000	1.000
311	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), HAL(3)	3668549	16	10	16	8	8	1	5	0	2	0	0.899	1.000	1.000
312	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(1), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2)	3378842	18	14	18	7	9	2	4	2	1	0	0.712	1.000	1.000
313	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1)	4534686	24	18	24	8	13	1	4	3	3	0	0.672	1.000	1.000
314	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(1), CD3E(1), FOS(3), FYN(1), HRAS(6), LAT(1), LCK(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3CA(26), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(2), SOS1(5), SYT1(2), VAV1(2), ZAP70(1)	9233999	104	69	88	20	61	6	17	11	9	0	0.0474	1.000	1.000
315	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), ATG7(1), BECN1(2), GABARAP(1), IFNA16(1), IFNA4(3), IFNG(1), PIK3C3(5), PIK3R4(3), PRKAA2(4), ULK1(3), ULK2(5)	4047642	31	23	31	9	18	2	8	3	0	0	0.549	1.000	1.000
316	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTFMT(1), MTR(3), SRM(2)	4005994	16	14	16	5	8	2	3	1	2	0	0.542	1.000	1.000
317	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH3A1(2), ALDH9A1(2), CYP2C19(1), CYP2C9(2), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1)	5968722	34	29	34	8	20	0	8	2	4	0	0.277	1.000	1.000
318	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME3(1), PKLR(1), PKM2(2), RPIA(2), TKTL1(3), TKTL2(1)	3902271	16	13	16	8	10	0	3	1	2	0	0.785	1.000	1.000
319	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME2(1), ME3(1), PKLR(1), PKM2(2), RPIA(2)	3489668	13	10	13	5	8	0	3	1	1	0	0.644	1.000	1.000
320	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2)	4817399	28	24	28	7	15	0	8	3	2	0	0.423	1.000	1.000
321	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CALM1(1), CALM2(1), CAPNS2(1), EP300(26), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SYT1(2)	4717869	58	40	58	14	20	5	9	9	15	0	0.434	1.000	1.000
322	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2)	3959552	18	17	18	8	7	0	8	1	2	0	0.704	1.000	1.000
323	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT3(1), BTK(3), CDKN2A(8), GSK3A(1), INPP5D(2), PIK3CA(26), PPP1R13B(3), PTEN(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SOS1(5), SOS2(4), TEC(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3)	6943543	79	45	64	16	55	3	8	4	9	0	0.166	1.000	1.000
324	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), RHOA(5), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3)	10142431	101	64	100	19	59	1	15	13	13	0	0.0410	1.000	1.000
325	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), RHOA(5), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3)	10142431	101	64	100	19	59	1	15	13	13	0	0.0410	1.000	1.000
326	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CSK(4), DAG1(1), EPHB2(3), FBXW7(16), GRAP2(2), ITK(2), ITPKA(2), ITPKB(1), LAT(1), LCK(1), NCK1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLCG1(3), PTPRC(5), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), SOS1(5), SOS2(4), VAV1(2), ZAP70(1)	10779706	95	60	91	17	47	3	18	9	18	0	0.0353	1.000	1.000
327	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(6), DDX20(2), E2F1(1), E2F4(1), ETS1(2), ETV3(1), FOS(3), HDAC2(1), HDAC5(2), HRAS(6), NCOR2(10), RBL1(1), RBL2(3), SIN3A(4)	5039557	45	37	44	11	17	1	14	6	7	0	0.285	1.000	1.000
328	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), ESCO1(1), ESCO2(1), HPD(2), LPO(4), MAOA(1), MPO(2), MYST3(5), MYST4(3), PNPLA3(2), PRDX6(4), TPO(9)	6602111	47	37	46	10	23	0	15	5	4	0	0.136	1.000	1.000
329	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(2), ALOX5(2), CYP4F2(4), CYP4F3(2), EPX(2), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3), TPO(9)	5401593	56	41	55	17	28	0	14	5	9	0	0.286	1.000	1.000
330	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MYC(1), PIK3CA(26), PIK3R1(2), RAF1(1), SOS1(5), STAT1(4), STAT5B(2)	5427924	64	50	48	15	41	4	9	7	3	0	0.253	1.000	1.000
331	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(1), FPR1(1), GNA15(1), GNB1(5), HRAS(6), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NCF2(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(2)	7374256	68	46	67	15	31	6	15	10	6	0	0.178	1.000	1.000
332	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(3), CALM1(1), CALM2(1), CD79A(1), CD79B(1), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), RAC1(1), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2)	7389471	70	52	69	15	34	3	14	11	8	0	0.160	1.000	1.000
333	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(8), DIAPH1(2), FYN(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MYL2(2), MYLK(5), PFN1(2), PIK3CA(26), PIK3R1(2), PTK2(3), RAF1(1), ROCK1(4), SRC(4), TLN1(2)	7215814	74	51	58	15	49	2	11	8	4	0	0.126	1.000	1.000
334	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ACY1(1), ADC(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(1), SAT2(1), SRM(2)	5688955	26	21	26	8	14	1	6	2	3	0	0.409	1.000	1.000
335	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT3(1), ANKRD6(3), APC(7), AXIN1(3), AXIN2(4), CER1(2), CSNK1A1(3), CTNNB1(4), DACT1(2), DKK1(1), DKK2(3), DKK3(3), DKK4(1), FSTL1(1), GSK3A(1), LRP1(12), MVP(4), PSEN1(5), PTPRA(1), WIF1(2)	7815319	63	47	62	13	28	3	15	5	12	0	0.157	1.000	1.000
336	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), DOCK1(4), FOS(3), GAB1(2), HGF(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAP4K1(3), MAPK3(3), MAPK8(4), MET(5), PIK3CA(26), PIK3R1(2), PTEN(5), PTK2(3), PTK2B(3), RAF1(1), RAP1A(1), RAP1B(2), RASA1(4), SOS1(5), SRC(4)	8508857	93	61	77	19	59	4	16	8	6	0	0.0994	1.000	1.000
337	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2), CPT1A(2), CPT1B(2), CPT1C(2), CYP4A11(2), CYP4A22(4), EHHADH(1), GCDH(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(3)	9463608	52	40	52	12	36	1	6	4	5	0	0.124	1.000	1.000
338	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(4), GNB1(5), HRAS(6), IGF1R(5), ITGB1(1), KLK2(1), MAP2K1(1), MAPK3(3), MKNK1(1), MYC(1), NGFR(3), PDGFRA(7), PPP2CA(1), PTPRR(1), RAF1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5), SRC(4)	6414231	57	40	56	14	28	3	17	8	1	0	0.239	1.000	1.000
339	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CA(26), PIK3CD(3), PIK3R1(2), SYT1(2), TRAF2(2), TRAF6(1)	6506849	79	55	64	21	47	4	13	8	7	0	0.249	1.000	1.000
340	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT3(1), BTK(3), CD19(2), CDKN2A(8), GAB1(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), PHF11(1), PIK3CA(26), PLCG2(3), PPP1R13B(3), PREX1(3), PTEN(5), PTPRC(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SYK(1), TEC(4), VAV1(2)	10646368	97	59	82	22	60	5	12	7	13	0	0.0736	1.000	1.000
341	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(2), ASAH1(2), B4GALT6(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SGMS2(1), SMPD1(3), SMPD2(2), SMPD3(1), SMPD4(3), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(1), UGT8(2)	6902767	54	39	54	16	26	1	13	5	9	0	0.325	1.000	1.000
342	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(1), ACVR1C(1), AKT3(1), ARRB1(1), BDNF(1), BRAF(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CACNA2D1(5), CACNA2D2(3), CACNA2D3(1), CACNA2D4(1), CACNB1(2), CACNB2(2), CACNB4(1), CACNG2(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG6(2), CACNG7(1), CACNG8(1), CASP3(1), CHUK(6), DAXX(1), DUSP10(3), DUSP14(2), DUSP16(4), DUSP2(1), DUSP4(1), DUSP6(3), DUSP7(3), DUSP8(3), ECSIT(1), EGF(4), EGFR(3), ELK4(1), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR3(21), FGFR4(3), FLNA(5), FLNB(6), FLNC(5), FOS(3), GADD45A(1), HRAS(6), IKBKB(4), IL1A(1), IL1B(1), JUND(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MAPKAPK2(1), MAPT(5), MEF2C(2), MKNK1(1), MOS(2), MYC(1), NF1(13), NFATC2(6), NFATC4(1), NFKB1(1), NFKB2(1), NLK(2), NR4A1(1), NRAS(2), NTF3(1), NTRK1(4), NTRK2(4), PAK2(1), PDGFB(1), PDGFRA(7), PDGFRB(4), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PPM1A(3), PPM1B(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PPP5C(1), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPN7(1), PTPRR(1), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RAPGEF2(6), RASA1(4), RASA2(1), RASGRF1(2), RASGRF2(2), RASGRP1(1), RASGRP2(2), RASGRP3(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), RPS6KA6(2), RRAS(1), SOS1(5), SOS2(4), STK3(2), STK4(3), TAOK1(2), TAOK2(5), TAOK3(2), TGFB3(1), TGFBR2(3), TP53(75), TRAF2(2), TRAF6(1), ZAK(1)	55196447	502	122	466	152	207	18	148	54	75	0	0.244	1.000	1.000
343	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), ARHGAP5(8), BIRC3(1), BRAF(1), CAV2(1), CCND1(1), CCND3(5), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), CTNNB1(4), DIAPH1(2), DOCK1(4), EGF(4), EGFR(3), ERBB2(11), FARP2(2), FIGF(1), FLNA(5), FLNB(6), FLNC(5), FLT1(1), FN1(6), FYN(1), GRLF1(14), HGF(1), HRAS(6), IBSP(1), IGF1R(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), KDR(9), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MET(5), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARVB(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PDPK1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PRKCA(1), PRKCG(2), PTEN(5), PTK2(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RELN(13), RHOA(5), ROCK1(4), ROCK2(6), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SPP1(1), SRC(4), THBS2(6), THBS3(2), THBS4(2), TLN1(2), TLN2(5), TNC(5), TNN(2), TNR(7), TNXB(11), VAV1(2), VAV2(1), VAV3(2), VCL(1), VEGFB(2), VEGFC(1), VTN(2), VWF(7), ZYX(1)	71727353	570	120	550	199	293	18	126	69	64	0	0.965	1.000	1.000
344	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), APC(7), APC2(3), ARAF(1), ARHGEF1(6), ARHGEF12(4), ARHGEF4(2), ARHGEF6(2), ARHGEF7(3), ARPC2(3), ARPC4(1), ARPC5(1), BDKRB1(1), BRAF(1), CFL2(1), CHRM1(1), CHRM3(4), CHRM4(1), CSK(4), CYFIP1(4), CYFIP2(1), DIAPH1(2), DIAPH2(4), DIAPH3(4), DOCK1(4), EGF(4), EGFR(3), EZR(6), F2R(2), FGD1(4), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR3(21), FGFR4(3), FN1(6), GIT1(2), GNA13(5), GRLF1(14), HRAS(6), IQGAP1(3), IQGAP2(1), IQGAP3(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LIMK1(2), MAP2K1(1), MAPK3(3), MOS(2), MYH10(7), MYH14(1), MYH9(13), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), NCKAP1(5), NCKAP1L(4), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PFN1(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP1R12B(2), PTK2(3), RAC1(1), RAF1(1), RDX(2), RHOA(5), ROCK1(4), ROCK2(6), RRAS(1), SCIN(1), SLC9A1(1), SOS1(5), SOS2(4), SSH1(2), SSH2(6), SSH3(4), TIAM1(7), TIAM2(6), VAV1(2), VAV2(1), VAV3(2), VCL(1), WAS(1), WASF2(3), WASL(1)	53396905	462	120	435	129	248	9	104	53	48	0	0.114	1.000	1.000
345	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(4), ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), ATM(19), ATR(3), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCND1(1), CCND3(5), CCNE2(1), CCNH(3), CDC14B(2), CDC16(1), CDC25A(1), CDC27(3), CDC6(5), CDC7(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), CHEK1(1), CHEK2(5), CREBBP(18), CUL1(8), DBF4(6), E2F1(1), E2F2(1), E2F3(2), EP300(26), ESPL1(5), FZR1(2), GADD45A(1), HDAC1(1), HDAC2(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), ORC1L(1), ORC3L(3), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(10), PTTG1(1), RB1(19), RBL1(1), RBL2(3), SFN(1), SKP1(1), SKP2(1), SMAD2(2), SMAD3(5), SMAD4(2), SMC1A(3), SMC1B(2), TGFB3(1), TP53(75), WEE1(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3)	26168753	357	110	327	67	142	9	76	33	97	0	0.00844	1.000	1.000
346	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(13), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(9), EED(3), EHMT1(2), EHMT2(4), EZH1(2), EZH2(3), FBXO11(1), HCFC1(4), HSF4(2), KDM6A(32), MEN1(1), MLL(21), MLL2(40), MLL3(30), MLL4(13), MLL5(6), NSD1(7), OGT(2), PAXIP1(3), PPP1CA(4), PPP1CB(3), PRDM2(7), PRDM7(2), PRDM9(5), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), RBBP5(2), SETD1A(3), SETD2(9), SETD8(2), SETDB1(4), SETDB2(1), SMYD3(1), STK38(2), SUV420H1(9), SUZ12(4), WHSC1(7), WHSC1L1(2)	22988078	283	109	275	64	129	8	32	26	88	0	0.393	1.000	1.000
347	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(7), APC2(3), AXIN1(3), AXIN2(4), CAMK2B(2), CAMK2D(1), CAMK2G(3), CCND1(1), CCND3(5), CER1(2), CHD8(5), CREBBP(18), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK2A1(4), CSNK2B(2), CTBP1(1), CTBP2(1), CTNNB1(4), CTNNBIP1(1), CUL1(8), DAAM1(7), DAAM2(3), DKK1(1), DKK2(3), DKK4(1), DVL2(2), DVL3(1), EP300(26), FBXW11(1), FOSL1(1), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LEF1(2), LRP5(2), LRP6(1), MAP3K7(3), MAPK10(1), MAPK8(4), MAPK9(5), MYC(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PORCN(1), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRICKLE1(2), PRICKLE2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(5), RAC1(1), RHOA(5), ROCK1(4), ROCK2(6), RUVBL1(3), SFRP2(1), SFRP4(2), SKP1(1), SMAD2(2), SMAD3(5), SMAD4(2), TBL1X(1), TBL1XR1(2), TBL1Y(2), TP53(75), VANGL1(2), VANGL2(3), WIF1(2), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1)	31235905	358	109	330	82	140	18	100	34	66	0	0.0150	1.000	1.000
348	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ATP2A1(6), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), ATP2B4(5), AVPR1A(1), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CCKBR(3), CD38(1), CHRM1(1), CHRM3(4), CYSLTR2(1), EDNRA(1), EDNRB(2), EGFR(3), ERBB2(11), ERBB3(14), ERBB4(3), F2R(2), GNA14(2), GNA15(1), GNAL(1), GNAS(4), GRIN1(6), GRIN2A(9), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), HRH1(4), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), LHCGR(2), LTB4R2(2), MYLK(5), MYLK2(4), NOS1(4), NOS3(6), NTSR1(1), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), PDE1A(2), PDE1C(4), PDGFRA(7), PDGFRB(4), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGER3(1), PTGFR(2), PTK2B(3), RYR1(12), RYR2(21), RYR3(14), SLC25A4(1), SLC25A6(1), SLC8A1(2), SLC8A2(2), SLC8A3(2), SPHK2(4), TACR1(2), TACR3(1), TRHR(2), TRPC1(2), VDAC1(1), VDAC2(2)	51940047	420	108	414	177	191	15	133	48	33	0	0.916	1.000	1.000
349	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(19), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCND3(5), CCNE2(1), CCNH(3), CDAN1(4), CDC14B(2), CDC25A(1), CDC6(5), CDC7(1), CDH1(6), CDK2(1), CDK4(2), CDKN1A(18), CDKN2A(8), CHEK1(1), CHEK2(5), DTX4(1), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), EP300(26), ESPL1(5), GADD45A(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MPEG1(2), MPL(1), ORC1L(1), ORC3L(3), PCNA(1), PLK1(1), PRKDC(10), PTPRA(1), PTTG1(1), RB1(19), RBL1(1), SKP2(1), SMAD4(2), TBC1D8(3), TP53(75), WEE1(2)	21182472	290	107	262	63	109	7	61	30	83	0	0.0651	1.000	1.000
350	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(5), ACTG1(4), COL11A1(10), COL11A2(3), COL17A1(2), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), DSC1(4), DSC2(2), DSC3(2), DSG1(7), DSG2(5), DSG3(1), DSG4(1), FN1(6), GJA1(1), GJA10(2), GJA9(2), GJC1(1), GJD2(2), IBSP(1), INA(1), ITGA6(2), ITGB4(5), KRT12(2), KRT13(1), KRT14(1), KRT15(3), KRT16(1), KRT17(1), KRT18(3), KRT2(1), KRT20(1), KRT24(1), KRT25(1), KRT28(1), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT6A(2), KRT6B(3), KRT6C(3), KRT7(2), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT78(1), KRT79(3), KRT8(1), KRT82(1), KRT83(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), LMNA(1), LMNB1(2), LMNB2(1), NES(8), PRPH(2), RELN(13), SPP1(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VIM(2), VTN(2), VWF(7)	48145810	350	106	347	146	184	16	79	39	32	0	0.999	1.000	1.000
351	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT3(1), BCL2L1(2), CBL(4), CBLB(6), CCND1(1), CCND3(5), CISH(1), CLCF1(2), CNTF(1), CNTFR(1), CREBBP(18), CSF2RA(1), CSF2RB(1), CSF3R(2), EP300(26), EPOR(1), GHR(2), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL9R(1), IRF9(2), JAK1(3), JAK2(2), JAK3(3), LEPR(4), LIFR(3), MPL(1), MYC(1), OSM(2), OSMR(3), PIAS3(1), PIAS4(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRL(2), PRLR(1), SOCS5(1), SOCS7(1), SOS1(5), SOS2(4), SPRED1(2), SPRED2(2), SPRY1(1), SPRY4(2), STAM(1), STAM2(4), STAT1(4), STAT2(2), STAT4(1), STAT5B(2), STAT6(3), TPO(9), TYK2(2)	28078660	255	106	239	78	124	10	48	30	43	0	0.536	1.000	1.000
352	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CALCR(2), CALCRL(2), CCKBR(3), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CRHR2(1), CTSG(3), CYSLTR2(1), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GABBR1(2), GABBR2(3), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GABRB1(2), GABRB2(3), GABRB3(2), GABRE(1), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(1), GABRR1(2), GABRR2(1), GALR1(1), GALR2(3), GALR3(1), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(2), GPR156(2), GPR50(5), GPR63(2), GPR83(1), GRIA1(3), GRIA2(3), GRIA3(2), GRIA4(5), GRID1(2), GRID2(2), GRIK1(7), GRIK2(4), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(2), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM6(4), GRM7(4), GRM8(1), GZMA(4), HCRTR2(2), HRH1(4), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LEPR(4), LHCGR(2), LTB4R2(2), MC3R(1), MC4R(2), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NPBWR2(1), NPFFR1(2), NPFFR2(3), NPY1R(1), NPY5R(4), NR3C1(1), NTSR1(1), OPRD1(2), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PARD3(6), PRL(2), PRLR(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER3(1), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(2), RXFP2(2), SCTR(3), SSTR1(1), SSTR3(2), SSTR4(3), TAAR5(1), TAAR8(3), TAAR9(1), TACR1(2), TACR3(1), TRHR(2), TRPV1(2), TSHR(2), UTS2R(1), VIPR1(1), VIPR2(4)	42744573	335	105	334	162	156	13	98	32	36	0	0.958	1.000	1.000
353	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(3), CD36(1), CD47(1), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), DAG1(1), FN1(6), FNDC1(8), FNDC3A(6), GP5(1), GP6(1), HSPG2(8), IBSP(1), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), RELN(13), SDC1(2), SDC3(1), SPP1(1), SV2A(2), SV2B(5), SV2C(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VTN(2), VWF(7)	43348280	310	104	308	119	157	12	70	35	36	0	0.994	1.000	1.000
354	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), AMOTL1(6), ASH1L(13), CASK(1), CDK4(2), CGN(2), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CSDA(1), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CTTN(2), EPB41(5), EPB41L1(4), EPB41L3(6), EXOC3(2), EXOC4(5), F11R(1), GNAI1(1), GNAI3(2), HCLS1(1), HRAS(6), IGSF5(2), INADL(5), JAM2(1), JAM3(1), LLGL1(1), LLGL2(1), MAGI1(4), MAGI2(7), MAGI3(7), MLLT4(3), MPDZ(12), MPP5(2), MYH1(5), MYH10(7), MYH11(4), MYH13(6), MYH14(1), MYH15(6), MYH2(5), MYH3(7), MYH4(5), MYH6(3), MYH7(8), MYH7B(6), MYH8(3), MYH9(13), MYL2(2), MYLPF(1), NRAS(2), OCLN(3), PARD3(6), PARD6A(3), PARD6B(1), PARD6G(1), PPM1J(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP2R3A(7), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PTEN(5), RAB3B(1), RHOA(5), RRAS(1), SPTAN1(34), SRC(4), SYMPK(4), TJAP1(1), TJP1(3), TJP2(5), VAPA(2), YES1(1), ZAK(1)	37493611	342	104	340	108	188	18	56	27	53	0	0.671	1.000	1.000
355	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(1), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL1(3), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL21(1), CCL23(1), CCL25(1), CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CD27(1), CD40(1), CLCF1(2), CNTF(1), CNTFR(1), CSF1(2), CSF1R(6), CSF2RA(1), CSF2RB(1), CSF3R(2), CX3CL1(5), CX3CR1(3), CXCL11(1), CXCL13(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCR3(1), CXCR4(2), EDA(1), EGF(4), EGFR(3), EPOR(1), FLT1(1), FLT3(3), FLT4(1), GDF5(1), GHR(2), HGF(1), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL17A(1), IL17B(3), IL17RA(1), IL18R1(1), IL18RAP(6), IL19(2), IL1A(1), IL1B(1), IL1RAP(1), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL8(1), IL9R(1), INHBB(1), INHBE(2), KDR(9), KIT(3), KITLG(2), LEPR(4), LIFR(3), MET(5), MPL(1), NGFR(3), OSM(2), OSMR(3), PDGFB(1), PDGFRA(7), PDGFRB(4), PLEKHO2(3), PPBP(2), PRL(2), PRLR(1), TGFB3(1), TGFBR2(3), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFRSF13C(1), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFRSF4(1), TNFRSF8(4), TNFRSF9(2), TNFSF10(2), TNFSF11(1), TNFSF13B(3), TNFSF14(1), TNFSF4(1), TNFSF8(3), TPO(9), VEGFB(2), VEGFC(1)	34218925	275	101	274	100	133	5	72	35	30	0	0.789	1.000	1.000
356	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(3), ACTN3(2), ACTN4(4), DMD(7), FAM48A(2), MYBPC1(5), MYBPC2(2), MYBPC3(2), MYH3(7), MYH6(3), MYH7(8), MYH8(3), MYL2(2), MYOM1(5), NEB(15), TCAP(1), TMOD1(1), TNNI1(2), TNNI2(1), TNNI3(1), TNNT1(3), TPM1(1), TPM2(2), TTN(140), VIM(2)	25820783	230	101	230	60	113	8	57	36	16	0	0.356	1.000	1.000
357	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(19), CCNA1(1), CCNB1(1), CCND1(1), CCND3(5), CCNE2(1), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), CREB3L3(5), CREB3L4(2), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), GADD45A(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MNAT1(1), MYC(1), MYT1(3), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLE(6), POLE2(1), RB1(19), RBL1(1), RPA3(3), TNXB(11), TP53(75), WEE1(2)	14875088	227	99	199	44	83	4	54	14	72	0	0.0245	1.000	1.000
358	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(4), CDK5(1), CFL2(1), CXCR4(2), DCC(8), DPYSL2(1), EFNA5(1), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(3), EPHA2(8), EPHA3(1), EPHA5(5), EPHA6(3), EPHA7(2), EPHA8(3), EPHB1(4), EPHB2(3), EPHB3(1), EPHB4(3), EPHB6(3), FES(1), FYN(1), GNAI1(1), GNAI3(2), HRAS(6), ITGB1(1), L1CAM(2), LIMK1(2), LRRC4C(1), MAPK3(3), MET(5), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NGEF(1), NRAS(2), NRP1(2), NTN1(4), NTN4(1), NTNG1(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(8), PLXNB3(3), PLXNC1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PTK2(3), RAC1(1), RASA1(4), RGS3(1), RHOA(5), RND1(2), ROBO1(6), ROBO2(6), ROBO3(2), ROCK1(4), ROCK2(6), SEMA3A(6), SEMA3B(2), SEMA3C(2), SEMA3D(7), SEMA3E(1), SEMA3F(3), SEMA3G(2), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5A(6), SEMA5B(7), SEMA6B(2), SEMA6C(6), SEMA6D(4), SLIT1(2), SLIT3(4), SRGAP1(1), SRGAP2(3), SRGAP3(1), UNC5A(3), UNC5B(1), UNC5C(2), UNC5D(3)	38055970	286	99	285	103	137	10	75	35	29	0	0.811	1.000	1.000
359	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ANXA6(3), ARRB1(1), ATP1A4(5), ATP1B2(3), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1S(5), CACNB1(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CASQ1(2), CASQ2(1), CHRM1(1), CHRM3(4), CHRM4(1), GJA1(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNB1(3), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(1), PKIA(1), PKIG(1), PLCB3(6), PLN(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SLC8A3(2), USP5(1), YWHAB(2), YWHAQ(1)	36164884	271	96	270	127	129	13	76	30	23	0	0.987	1.000	1.000
360	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ARHGAP5(8), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CXCR4(2), EZR(6), F11R(1), GNAI1(1), GNAI3(2), GRLF1(14), ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), ITK(2), JAM2(1), JAM3(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(3), MMP2(2), MMP9(3), MYL2(2), MYLPF(1), NCF2(4), NCF4(2), NOX1(1), OCLN(3), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), PTK2B(3), RAC1(1), RAP1A(1), RAP1B(2), RAPGEF4(4), RHOA(5), RHOH(1), ROCK1(4), ROCK2(6), SIPA1(3), TXK(4), VAV1(2), VAV2(1), VAV3(2), VCAM1(1), VCL(1)	24010358	211	96	196	58	114	7	39	22	29	0	0.178	1.000	1.000
361	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ACTA2(3), ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADM(3), ARRB1(1), ATF1(1), ATP2A2(2), ATP2A3(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CNN1(2), CNN2(2), DGKZ(3), FOS(3), GABPA(4), GJA1(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), GSTO1(1), GUCY1A3(6), IL1B(1), IL6(2), ITPR1(7), ITPR2(9), ITPR3(4), MAFF(1), MIB1(4), MYL2(2), MYLK2(4), NFKB1(1), NOS1(4), NOS3(6), OXTR(1), PDE4B(1), PDE4D(2), PKIA(1), PKIG(1), PLCB3(6), PLCD1(1), PLCG1(3), PLCG2(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP1(1), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RLN1(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SP1(3), TNXB(11), USP5(1), YWHAB(2), YWHAQ(1)	33396247	263	96	262	108	133	12	66	29	23	0	0.912	1.000	1.000
362	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(1), AKT3(1), ARAF(1), BRAF(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CBL(4), CBLB(6), CDKN1A(18), CDKN1B(5), EGF(4), EGFR(3), EIF4EBP1(1), ERBB2(11), ERBB3(14), ERBB4(3), GAB1(2), HRAS(6), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MYC(1), NCK1(1), NRAS(2), NRG1(5), NRG3(3), NRG4(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), RAF1(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SRC(4), STAT5B(2)	19916603	203	95	181	53	101	9	42	23	28	0	0.264	1.000	1.000
363	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT3(1), APAF1(1), ATM(19), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), CSF2RB(1), DFFA(4), FADD(1), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL3RA(3), IRAK2(1), IRAK3(3), IRAK4(3), MAP3K14(2), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), RIPK1(2), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), TP53(75), TRADD(1), TRAF2(2)	16141988	225	95	185	43	101	7	58	20	39	0	0.00330	1.000	1.000
364	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ACVR1B(1), ACVR1C(1), CDH1(6), CREBBP(18), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), EGFR(3), EP300(26), ERBB2(11), FARP2(2), FER(4), FGFR1(3), FYN(1), IGF1R(5), INSR(4), IQGAP1(3), LEF1(2), LMO7(4), MAP3K7(3), MAPK3(3), MET(5), MLLT4(3), NLK(2), PARD3(6), PTPRB(5), PTPRF(4), PTPRJ(2), PTPRM(2), PVRL1(4), PVRL2(2), PVRL3(2), PVRL4(2), RAC1(1), RHOA(5), SMAD2(2), SMAD3(5), SMAD4(2), SNAI1(1), SORBS1(4), SRC(4), SSX2IP(1), TGFBR2(3), TJP1(3), VCL(1), WAS(1), WASF2(3), WASF3(1), WASL(1), YES1(1)	23167340	214	95	211	62	104	7	47	21	35	0	0.521	1.000	1.000
365	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(2), CADM1(1), CADM3(1), CD2(1), CD22(2), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD58(1), CD6(2), CD86(1), CD8A(2), CDH1(6), CDH15(3), CDH2(1), CDH3(1), CDH4(7), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CNTN1(4), CNTNAP2(8), F11R(1), GLG1(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), ICAM1(3), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(5), ITGA9(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB8(1), JAM2(1), JAM3(1), L1CAM(2), MADCAM1(1), MAG(1), MPZ(4), NCAM1(3), NCAM2(3), NEGR1(1), NEO1(3), NFASC(2), NLGN1(2), NRCAM(1), NRXN1(8), NRXN2(3), NRXN3(3), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(5), PTPRF(4), PTPRM(2), PVR(2), PVRL1(4), PVRL2(2), PVRL3(2), SDC1(2), SDC3(1), SELE(1), SELP(1), SPN(1), VCAM1(1), VCAN(9)	28500766	202	93	201	86	89	4	52	25	32	0	0.989	1.000	1.000
366	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(13), ACACB(5), AKT3(1), ARAF(1), BRAF(1), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CBL(4), CBLB(6), EIF4EBP1(1), EXOC7(2), FASN(2), FBP1(1), FOXO1(1), GYS1(3), GYS2(3), HRAS(6), IKBKB(4), INPP5D(2), INSR(4), IRS1(3), IRS2(3), IRS4(8), LIPE(5), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MKNK1(1), NRAS(2), PCK1(3), PDE3A(5), PDE3B(1), PDPK1(1), PFKP(1), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PKLR(1), PKM2(2), PPARGC1A(2), PPP1CA(4), PPP1CB(3), PPP1R3A(4), PPP1R3B(2), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(1), PTPRF(4), PYGL(1), PYGM(4), RAF1(1), RHEB(1), RHOQ(1), RPS6(3), SHC2(1), SHC4(4), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), SREBF1(4), TRIP10(2), TSC1(11), TSC2(2)	31021361	251	93	233	86	138	8	51	25	29	0	0.731	1.000	1.000
367	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(5), CABIN1(3), CALM1(1), CALM2(1), CAMK2B(2), CAMK4(1), CD3E(1), CDKN1A(18), CEBPB(3), CNR1(1), CREBBP(18), CSNK2A1(4), CSNK2B(2), EGR2(1), EGR3(1), EP300(26), FCER1A(2), FOS(3), FOSL1(1), GATA3(1), GRLF1(14), GSK3A(1), HRAS(6), ICOS(2), IFNG(1), IL1B(1), IL2RA(1), IL6(2), IL8(1), ITK(2), JUNB(4), KPNA5(1), MAP2K7(2), MAPK14(1), MAPK8(4), MAPK9(5), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB2(1), NFKBIB(4), NFKBIE(5), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(5), RELA(2), SFN(1), SLA(1), SP1(3), SP3(2), TRAF2(2), TRPV6(2), VAV1(2), VAV2(1), VAV3(2), XPO5(6)	17591516	220	91	216	51	86	8	46	21	59	0	0.103	1.000	1.000
368	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BRAF(1), CASP3(1), CD244(2), CD247(1), FCGR3B(3), FYN(1), HCST(1), HLA-A(5), HLA-C(2), HLA-E(1), HRAS(6), ICAM1(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), ITGAL(2), ITGB2(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRD1(1), LAT(1), LCK(1), MAP2K1(1), MAPK3(3), MICA(2), MICB(1), NCR1(2), NCR2(2), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(3), RAC1(1), RAF1(1), SH2D1B(1), SH3BP2(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SYK(1), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(1), ULBP3(1), VAV1(2), VAV2(1), VAV3(2), ZAP70(1)	21882340	186	90	169	57	97	8	31	26	24	0	0.452	1.000	1.000
369	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(1), CALML3(1), CALML6(1), CDS1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPP5D(2), INPPL1(2), ITPK1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), PI4KB(3), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3C3(5), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PRKCA(1), PRKCG(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2)	24044779	189	89	173	71	109	7	34	22	17	0	0.875	1.000	1.000
370	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), ACTN1(2), ACTR3(1), AKT3(1), ARHGEF6(2), ARHGEF7(3), BRAF(1), CDKN2A(8), CSE1L(5), DOCK1(4), EPHB2(3), FYN(1), GRB7(1), GRLF1(14), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MYLK(5), MYLK2(4), P4HB(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CB(5), PKLR(1), PLCG1(3), PLCG2(3), PTEN(5), PTK2(3), RAF1(1), ROCK1(4), ROCK2(6), SOS1(5), SOS2(4), SRC(4), TERF2IP(2), TLN1(2), TLN2(5), WAS(1), ZYX(1)	23620702	206	89	191	53	116	6	35	21	28	0	0.153	1.000	1.000
371	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRB1(1), EGF(4), EGFR(3), GJA1(1), GJD2(2), GNAI1(1), GNAI3(2), GNAS(4), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), HRAS(6), HTR2B(2), HTR2C(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP3K2(2), MAPK3(3), MAPK7(2), NRAS(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), PRKX(1), RAF1(1), SOS1(5), SOS2(4), SRC(4), TJP1(3), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2)	25540838	197	88	195	75	93	8	62	20	14	0	0.760	1.000	1.000
372	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(5), ARAF(1), BRAF(1), CACNA1C(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CREBBP(18), EP300(26), GRIA1(3), GRIA2(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), HRAS(6), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAP1A(1), RAP1B(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2)	19220044	199	88	196	54	80	13	51	29	26	0	0.129	1.000	1.000
373	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BAX(1), BFAR(2), BTK(3), CAD(7), CASP3(1), CASP8(4), CASP8AP2(7), CD7(2), CSNK1A1(3), DAXX(1), DFFA(4), EGFR(3), EPHB2(3), FADD(1), FAF1(1), IL1A(1), IL8(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K5(4), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MET(5), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PFN1(2), PTPN13(7), RALBP1(1), RIPK1(2), ROCK1(4), SMPD1(3), TP53(75), TPX2(1), TRAF2(2)	14015354	198	87	173	37	87	2	59	16	34	0	0.00573	1.000	1.000
374	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), BIRC5(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CHUK(6), DFFA(4), FADD(1), HELLS(1), IKBKB(4), IRF1(1), IRF2(1), IRF4(1), IRF5(1), IRF6(3), IRF7(1), MAP2K4(1), MAP3K1(3), MAPK10(1), MYC(1), NFKB1(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PLEKHG5(2), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFSF10(2), TP53(75), TP73(2), TRADD(1), TRAF2(2)	11104849	162	86	137	31	57	2	60	11	32	0	0.0128	1.000	1.000
375	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADK(3), ADSL(1), ADSS(2), AK3L1(1), AK7(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), DCK(1), ENPP1(2), ENTPD2(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PDE10A(2), PDE11A(8), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(1), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6G(1), PDE6H(1), PDE7A(2), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PPAT(2), PRIM2(2), PRUNE(4), RRM1(1), RRM2(2), XDH(6)	31522643	211	86	211	84	107	7	53	21	23	0	0.958	1.000	1.000
376	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(1), ACVR1C(1), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP4(1), BMP5(1), BMP6(1), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(2), CHRD(5), COMP(5), CREBBP(18), CUL1(8), E2F4(1), E2F5(1), EP300(26), FST(2), GDF5(1), GDF6(3), ID1(1), IFNG(1), INHBB(1), INHBE(2), LTBP1(5), MAPK3(3), MYC(1), NODAL(1), NOG(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), RBL1(1), RBL2(3), RHOA(5), ROCK1(4), ROCK2(6), SKP1(1), SMAD1(1), SMAD2(2), SMAD3(5), SMAD4(2), SMAD6(1), SMAD7(2), SMAD9(2), SMURF1(4), SMURF2(1), SP1(3), TGFB3(1), TGFBR2(3), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(4), ZFYVE9(6)	19121656	182	86	180	48	80	9	41	21	31	0	0.355	1.000	1.000
377	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCBP2(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CCRL1(1), CCRL2(1), CHML(2), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR3(1), CXCR4(2), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR17(3), GPR173(1), GPR174(1), GPR37(2), GPR37L1(3), GPR4(2), GPR50(5), GPR63(2), GPR77(1), GPR83(1), GPR87(2), HCRTR2(2), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LHCGR(2), MC3R(1), MC4R(2), MLNR(1), MTNR1A(1), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPN1SW(1), OPRD1(2), OR10A5(2), OR11A1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7A5(3), OR7C1(3), OR8B8(2), OXTR(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), RRH(1), SSTR1(1), SSTR3(2), SSTR4(3), SUCNR1(1), TRHR(2)	23466006	176	84	176	102	78	9	58	20	11	0	0.976	1.000	1.000
378	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT3(1), BCL10(1), CARD11(5), CBL(4), CBLB(6), CD247(1), CD3E(1), CD4(1), CD8A(2), CDK4(2), CHUK(6), FOS(3), FYN(1), GRAP2(2), HRAS(6), ICOS(2), IFNG(1), IKBKB(4), ITK(2), LAT(1), LCK(1), MALT1(5), MAP3K14(2), MAP3K8(2), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCQ(1), PTPRC(5), RASGRP1(1), RHOA(5), SOS1(5), SOS2(4), TEC(4), VAV1(2), VAV2(1), VAV3(2), ZAP70(1)	19600343	195	84	179	49	108	9	30	25	23	0	0.154	1.000	1.000
379	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CREB3L2(1), CREB3L3(5), CREB3L4(2), CREBBP(18), CTNNB1(4), DCT(3), DVL2(2), DVL3(1), EDNRB(2), EP300(26), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), HRAS(6), KIT(3), KITLG(2), LEF1(2), MAP2K1(1), MAPK3(3), MITF(1), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TYR(3), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1)	21056535	179	83	176	75	73	7	56	23	20	0	0.931	1.000	1.000
380	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT3(1), CASP8(4), CCL3(1), CD40(1), CD86(1), CHUK(6), CXCL11(1), FADD(1), FOS(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IKBKB(4), IKBKE(2), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK4(3), IRF5(1), IRF7(1), LY96(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K7(3), MAP3K8(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), RAC1(1), RELA(2), RIPK1(2), SPP1(1), STAT1(4), TBK1(3), TICAM1(2), TLR2(2), TLR3(2), TLR4(3), TLR5(5), TLR6(2), TLR7(6), TLR8(3), TLR9(2), TOLLIP(1), TRAF6(1)	17303766	159	82	144	46	90	7	23	17	22	0	0.291	1.000	1.000
381	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(1), CACNA1A(6), GNA13(5), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(3), GRIA2(3), GRIA3(2), GRID2(2), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), HRAS(6), IGF1R(5), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP2K1(1), MAPK3(3), NOS1(4), NOS3(6), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), RAF1(1), RYR1(12)	21307832	164	82	161	64	76	6	42	26	14	0	0.854	1.000	1.000
382	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), CAPN10(1), CAPN11(1), CAPN3(4), CAPN5(3), CAPN6(1), CAPN9(1), CAV2(1), CSK(4), DOCK1(4), FYN(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), MAP2K1(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MAPK7(2), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(3), RAC1(1), RAP1B(2), ROCK1(4), ROCK2(6), SDCCAG8(2), SORBS1(4), SOS1(5), SRC(4), TLN1(2), TNS1(8), VAV2(1), VAV3(2), VCL(1), ZYX(1)	25876391	158	82	158	62	75	3	41	22	17	0	0.929	1.000	1.000
383	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT3(1), CASP9(3), HRAS(6), KDR(9), MAP2K1(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NOS3(6), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCA(1), PRKCG(2), PTGS2(2), PTK2(3), RAC1(1), RAF1(1), SH2D2A(3), SHC2(1), SPHK2(4), SRC(4)	13955892	146	81	130	32	77	7	25	20	17	0	0.0294	1.000	1.000
384	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CACNA1C(5), CACNA1D(5), CACNA1F(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), EGFR(3), GNAS(4), GNRH1(1), HRAS(6), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK9(5), MMP14(1), MMP2(2), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLD1(3), PLD2(1), PRKACB(1), PRKCA(1), PRKCD(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(5), SOS2(4), SRC(4)	24592111	181	81	179	86	78	8	57	20	18	0	0.993	1.000	1.000
385	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), ACVRL1(3), BMPR1A(1), BMPR2(5), BUB1(8), CDKL1(3), CDKL2(2), CDS1(2), CLK1(3), CLK4(1), COL4A3BP(1), CSNK2A1(4), CSNK2B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), PAK4(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CA(26), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3), PLK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), VRK1(1)	21801298	173	81	156	57	91	9	32	25	16	0	0.699	1.000	1.000
386	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), AKAP1(3), AKAP10(3), AKAP11(8), AKAP12(2), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(7), AKAP8(1), AKAP9(15), ARHGEF1(6), CALM1(1), CALM2(1), CHMP1B(2), GNA13(5), GNA14(2), GNA15(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB5(2), GNG4(4), HRAS(6), ITPR1(7), KCNJ3(1), NRAS(2), PALM2(1), PDE1A(2), PDE1C(4), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE7A(2), PDE7B(1), PDE8A(1), PLCB3(6), PPP3CA(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(7), RHOA(5), RRAS(1), SLC9A1(1), USP5(1)	22598710	189	80	185	60	95	9	40	27	18	0	0.602	1.000	1.000
387	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(7), AMY2A(2), AMY2B(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENPP1(2), ENTPD7(2), EP400(7), ERCC2(16), ERCC3(2), GAA(2), GANC(3), GBA(2), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), IFIH1(3), MGAM(6), MOV10L1(1), PGM1(2), PYGL(1), PYGM(4), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SI(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1), TREH(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1)	23807323	173	80	168	59	80	12	40	27	14	0	0.846	1.000	1.000
388	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT3(1), BCL10(1), BLNK(1), BTK(3), CARD11(5), CD19(2), CD22(2), CD79A(1), CD79B(1), CHUK(6), CR2(6), FCGR2B(1), FOS(3), HRAS(6), IKBKB(4), INPP5D(2), LILRB3(2), LYN(2), MALT1(5), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), RAC1(1), RASGRP3(2), SYK(1), VAV1(2), VAV2(1), VAV3(2)	14392776	154	79	138	41	76	9	27	20	22	0	0.246	1.000	1.000
389	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT3(1), BCL2L1(2), CDK2(1), CDKN1B(5), CDKN2A(8), CREB5(5), ERBB4(3), GAB1(2), GADD45A(1), GSK3A(1), IFI27(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), MET(5), MYC(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARD3(6), PARD6A(3), PIK3CA(26), PIK3CD(3), PPP1R13B(3), PREX1(3), PTEN(5), PTK2(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SLC2A4(1), SOS1(5), SOS2(4), TSC1(11), TSC2(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3)	14954080	151	76	136	34	77	5	27	9	33	0	0.114	1.000	1.000
390	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(2), CREBBP(18), CTBP1(1), CTBP2(1), DLL1(4), DLL3(2), DLL4(1), DTX1(5), DTX2(2), DTX3(1), DTX4(1), DVL2(2), DVL3(1), EP300(26), HDAC1(1), HDAC2(1), HES1(4), JAG1(4), LFNG(1), MAML1(1), MAML2(5), MAML3(3), NCOR2(10), NCSTN(6), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), NUMB(1), PSEN1(5), RBPJ(2), RBPJL(2), SNW1(1)	13412281	132	75	130	39	54	5	33	14	26	0	0.513	1.000	1.000
391	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT3(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(6), CSK(4), DAG1(1), GSK3A(1), INPP5D(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP4K1(3), MAPK3(3), NFATC1(4), NFATC2(6), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(5), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2)	14317456	126	75	111	37	74	10	15	15	12	0	0.329	1.000	1.000
392	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(1), MINPP1(1), PI4KB(3), PIK3C3(5), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2)	14359947	118	73	102	43	74	2	23	12	7	0	0.769	1.000	1.000
393	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(6), BDKRB1(1), C1R(1), C1S(2), C2(1), C3(5), C4BPA(4), C5(3), C8A(2), C8B(2), C9(5), CD46(2), CD55(1), CFB(2), CFH(6), CFI(1), CPB2(3), CR1(3), CR2(6), F10(1), F11(3), F12(1), F13A1(2), F13B(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), KNG1(1), MASP1(3), MASP2(3), PLAT(1), PLAU(1), PLAUR(6), PROS1(4), SERPINC1(1), SERPIND1(5), SERPINE1(2), SERPING1(1), THBD(2), VWF(7)	17450494	130	73	130	35	66	6	34	11	13	0	0.256	1.000	1.000
394	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(2), ATF1(1), BRAF(1), CREB5(5), CREBBP(18), DAG1(1), EGR1(1), EGR2(1), EGR3(1), FRS2(3), MAP1B(6), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NTRK1(4), PIK3C2G(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), RPS6KA3(2), SRC(4), TERF2IP(2)	9903872	109	73	93	28	59	6	20	11	13	0	0.225	1.000	1.000
395	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(2), CPSF4(1), CSTF2(1), CSTF2T(3), CSTF3(1), DDX1(1), DDX20(2), DHX16(3), DHX38(1), DHX8(2), DHX9(6), DICER1(5), FUS(4), LOC440563(3), LSM2(1), METTL3(2), NCBP1(1), NONO(1), NXF1(5), PABPN1(2), PAPOLA(7), PPM1G(3), PRPF18(1), PRPF3(1), PRPF4(3), PRPF4B(1), PRPF8(3), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(1), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SF3B5(1), SF4(2), SFRS14(2), SFRS16(1), SFRS2(3), SFRS6(3), SFRS8(3), SFRS9(3), SNRPB(2), SNRPB2(2), SNRPG(2), SPOP(2), SRPK2(2), SUPT5H(5), U2AF1(1), U2AF2(2), XRN2(3)	20460628	140	72	139	45	73	7	24	12	24	0	0.917	1.000	1.000
396	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(1), CALM1(1), CALM2(1), CAMK4(1), CREBBP(18), CSNK1A1(3), HAND2(1), HRAS(6), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MEF2C(2), MYH2(5), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PIK3CA(26), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RAF1(1), SYT1(2)	9788646	112	71	95	28	58	7	21	11	15	0	0.197	1.000	1.000
397	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(7), ABCA12(6), ABCA13(13), ABCA2(1), ABCA3(1), ABCA4(3), ABCA5(3), ABCA6(4), ABCA7(2), ABCA8(8), ABCA9(7), ABCB1(6), ABCB4(3), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(8), ABCC10(2), ABCC11(5), ABCC12(4), ABCC2(2), ABCC3(8), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(7), ABCD1(1), ABCD2(3), ABCD3(7), ABCG1(2), ABCG4(4), ABCG5(2), CFTR(2), TAP1(1), TAP2(1)	22683898	148	70	148	56	83	3	26	15	21	0	0.606	1.000	1.000
398	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(1), CHUK(6), DAXX(1), FOS(3), HRAS(6), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP3K9(1), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(3), MAPK7(2), MAPK8(4), MAPK9(5), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), NFKB1(1), NFKBIA(2), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), SP1(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2)	18400061	135	69	134	45	61	5	33	15	21	0	0.726	1.000	1.000
399	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADK(3), ADSL(1), ADSS(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), DCK(1), ENPP1(2), ENTPD2(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NT5E(3), PDE1A(2), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6B(1), PDE6C(2), PDE6G(1), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), PPAT(2), PRUNE(4), RRM1(1), RRM2(2)	24748758	150	69	150	66	84	6	34	13	13	0	0.971	1.000	1.000
400	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD19(2), CD1A(3), CD1B(1), CD1C(2), CD1D(2), CD1E(3), CD2(1), CD22(2), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(1), CD4(1), CD5(1), CD55(1), CD7(2), CD8A(2), CR1(3), CR2(6), CSF1(2), CSF1R(6), CSF2RA(1), CSF3R(2), DNTT(4), EPOR(1), FCGR1A(1), FLT3(3), GP5(1), HLA-DRA(1), HLA-DRB1(1), IL1A(1), IL1B(1), IL2RA(1), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(2), IL9R(1), ITGA1(1), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGAM(3), ITGB3(2), KIT(3), KITLG(2), MME(4), MS4A1(3), TFRC(2), THPO(1), TPO(9)	15758645	136	68	136	39	62	6	37	20	11	0	0.286	1.000	1.000
401	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(1), ACSL5(1), ACSL6(2), ADIPOR1(2), AGRP(1), AKT3(1), CAMKK2(3), CD36(1), CHUK(6), CPT1A(2), CPT1B(2), CPT1C(2), IKBKB(4), IRS1(3), IRS2(3), IRS4(8), JAK1(3), JAK2(2), JAK3(3), LEPR(4), MAPK10(1), MAPK8(4), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PCK1(3), PPARGC1A(2), PRKAA2(4), PRKAB2(1), PRKAG1(2), PRKCQ(1), RELA(2), RXRA(12), RXRG(5), SLC2A1(3), SLC2A4(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(2)	16072616	126	68	119	42	59	6	33	12	16	0	0.577	1.000	1.000
402	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR3(1), AKT3(1), ARHGAP1(1), ARHGEF11(3), BTK(3), CFL2(1), GDI1(2), INPPL1(2), ITPR1(7), ITPR2(9), ITPR3(4), LIMK1(2), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CD(3), PIK3CG(3), PIK3R1(2), PPP1R13B(3), PTEN(5), RACGAP1(1), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1)	13570348	110	68	95	29	66	4	12	15	13	0	0.246	1.000	1.000
403	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(4), APAF1(1), BAG4(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DAXX(1), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK8(4), NFKB1(1), NFKBIA(2), NUMA1(4), PAK2(1), PRKCD(1), PRKDC(10), PSEN1(5), PTK2(3), RASA1(4), RB1(19), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF1B(3), TRADD(1), TRAF2(2)	13333529	142	67	140	51	70	5	25	7	35	0	0.955	1.000	1.000
404	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(2), CHST6(1), CHST7(1), CHSY1(2), EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), FUT11(2), FUT8(5), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GANAB(8), GCNT1(1), GCNT4(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), NDST2(1), NDST3(2), NDST4(2), OGT(2), ST3GAL1(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(3), XYLT1(3), XYLT2(2)	21218133	127	67	126	56	75	3	17	20	12	0	0.945	1.000	1.000
405	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT3(1), BTK(3), FCER1A(2), FYN(1), GAB2(1), HRAS(6), INPP5D(2), LAT(1), LYN(2), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MS4A2(3), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCD(1), RAC1(1), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2), VAV2(1), VAV3(2)	13929341	121	67	105	39	63	4	22	21	11	0	0.593	1.000	1.000
406	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT3(1), BLNK(1), BTK(3), CD19(2), CSK(4), DAG1(1), EPHB2(3), ITPKA(2), ITPKB(1), LYN(2), MAP2K1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SOS1(5), SOS2(4), SYK(1), VAV1(2)	10208077	94	65	79	22	59	3	14	9	9	0	0.138	1.000	1.000
407	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ADAM17(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), CASP3(1), CHUK(6), CSK(4), EGFR(3), F11R(1), GIT1(2), IGSF5(2), IKBKB(4), IL8(1), JAM2(1), JAM3(1), LYN(2), MAP2K4(1), MAP3K14(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(5), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(1), PLCG1(3), PLCG2(3), PTPRZ1(7), RAC1(1), RELA(2), SRC(4), TCIRG1(1), TJP1(3)	13600610	115	62	115	29	58	5	30	8	14	0	0.139	1.000	1.000
408	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT3(1), BRD4(2), CAP1(5), CBL(4), CDKN2A(8), GSK3A(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), LNPEP(1), MAPK3(3), PARD3(6), PARD6A(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PTEN(5), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SERPINB6(2), SFN(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3)	11514854	118	62	103	29	68	5	18	9	18	0	0.265	1.000	1.000
409	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACOX1(1), ACOX2(2), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ANGPTL4(3), APOA2(1), APOA5(1), AQP7(2), CD36(1), CPT1A(2), CPT1B(2), CPT1C(2), CYP27A1(2), CYP4A11(2), CYP4A22(4), CYP7A1(4), CYP8B1(1), DBI(2), EHHADH(1), FADS2(1), GK2(3), LPL(1), ME1(2), PCK1(3), PDPK1(1), PLTP(1), PPARD(1), PPARG(3), RXRA(12), RXRG(5), SCD(1), SCP2(2), SLC27A1(1), SLC27A2(4), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(4), UCP1(2)	12654343	96	61	90	27	55	4	21	9	7	0	0.245	1.000	1.000
410	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CA(26), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3)	8640070	85	61	69	27	50	2	14	8	11	0	0.591	1.000	1.000
411	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ALG6(1), CCKBR(3), CCR3(3), CCR5(2), CELSR1(8), CELSR2(5), CELSR3(18), CHRM3(4), CIDEB(1), CXCR3(1), EDNRA(1), EMR2(1), F2R(2), FSHR(1), GHRHR(1), GPR116(2), GPR133(5), GPR135(1), GPR17(3), GPR55(2), GPR56(4), GPR61(4), GPR77(1), GPR84(2), GPR88(3), GRM1(7), HRH4(1), LGR6(3), LPHN2(8), LPHN3(5), LTB4R2(2), NTSR1(1), OR2M4(1), OR8G2(1), P2RY13(2), PTGFR(2), SMO(2), TAAR5(1), TSHR(2)	12862475	117	60	117	58	43	7	37	14	16	0	0.910	1.000	1.000
412	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(7), ASAH1(2), BRAF(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(3), GNA15(1), GNAI1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), MAPK10(1), MAPK14(1), PHKA2(1), PIK3CA(26), PIK3CD(3), PIK3R1(2), PTX3(1), RAF1(1), SRC(4)	10319766	84	59	69	23	51	4	11	8	10	0	0.269	1.000	1.000
413	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), CARM1(2), COMT(2), DBH(3), DCT(3), DDC(3), ESCO1(1), ESCO2(1), GSTZ1(1), HPD(2), LCMT2(1), MAOA(1), METTL2B(1), MYST3(5), MYST4(3), PNPLA3(2), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TPO(9), TYR(3), WBSCR22(3)	11472515	77	58	76	22	35	2	23	13	4	0	0.348	1.000	1.000
414	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), DAG1(1), DGKA(1), ITGA9(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NR1I3(2), PDE3A(5), PDE3B(1), PIK3C2G(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLDN(2), PSME1(1), RIPK3(1), RPS4X(2), SGCB(1)	9400689	82	58	67	29	54	5	7	8	8	0	0.685	1.000	1.000
415	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(2), CCND1(1), CREBBP(18), EP300(26), ERCC3(2), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), MEF2C(2), NCOR2(10), NRIP1(4), PELP1(2)	8892368	83	57	82	22	28	3	23	8	21	0	0.426	1.000	1.000
416	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PRIM2(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TXNRD2(1), TYMS(1), UMPS(1), UPB1(3), UPRT(1)	15663266	106	56	106	36	56	3	19	16	12	0	0.732	1.000	1.000
417	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(6), ATP4A(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), ATP5O(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), COX10(2), COX15(1), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB9(3), NDUFS1(2), NDUFS2(1), NDUFS6(1), NDUFV1(2), PPA1(1), SDHA(3), SDHC(2), TCIRG1(1), UQCRB(1), UQCRC2(2), UQCRH(1)	10801393	90	55	88	25	42	7	22	10	9	0	0.253	1.000	1.000
418	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT3(1), BRAF(1), CAB39(1), DDIT4(1), EIF4EBP1(1), FIGF(1), HIF1A(1), MAPK3(3), PDPK1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRKAA2(4), RHEB(1), RICTOR(4), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), TSC1(11), TSC2(2), ULK1(3), ULK2(5), VEGFB(2), VEGFC(1)	10257597	95	55	80	25	51	5	15	9	15	0	0.344	1.000	1.000
419	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2L1(2), CBL(4), CFLAR(1), E2F1(1), FOS(3), HRAS(6), IL2RA(1), IL2RB(2), IL2RG(3), IRS1(3), JAK1(3), JAK3(3), MAPK3(3), MYC(1), PIK3CA(26), PIK3R1(2), PPIA(1), RAF1(1), SOS1(5), STAT5B(2), SYK(1)	6993674	74	54	58	21	45	4	12	7	6	0	0.369	1.000	1.000
420	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3), TSC1(11), TSC2(2)	5344593	74	54	59	18	40	4	9	5	16	0	0.500	1.000	1.000
421	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), ATP8A1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR77(1), LHCGR(2), MC3R(1), MC4R(2), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPRD1(2), OXTR(1), SSTR1(1), SSTR3(2), SSTR4(3), TACR1(2), TACR3(1), TRHR(2), TSHR(2)	10121851	72	54	72	48	32	0	24	10	6	0	0.994	1.000	1.000
422	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(3), CALM1(1), CALM2(1), HDAC5(2), IGF1R(5), INSR(4), MAPK14(1), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1), NFATC1(4), NFATC2(6), PIK3CA(26), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(2)	6711350	74	53	59	21	39	5	12	9	9	0	0.352	1.000	1.000
423	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(3), ACAT1(1), AFMID(2), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CARM1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), KMO(1), LCMT2(1), LNX1(2), MAOA(1), METTL2B(1), NFX1(3), OGDH(5), OGDHL(4), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TDO2(1), WBSCR22(3)	11708801	73	53	72	21	40	6	10	11	6	0	0.377	1.000	1.000
424	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(4), AGPAT2(1), AGPAT3(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CHPT1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), ESCO1(1), ESCO2(1), ETNK1(1), GPD1(1), GPD1L(1), GPD2(1), LCAT(1), MYST3(5), MYST4(3), PCYT1A(1), PHOSPHO1(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1), PTDSS1(2)	12633261	82	53	82	36	42	4	17	9	10	0	0.959	1.000	1.000
425	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENTPD7(2), EP400(7), ERCC2(16), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(1), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1)	12109862	89	53	86	32	42	8	19	15	5	0	0.847	1.000	1.000
426	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(7), AXIN1(3), CREBBP(18), CTNNB1(4), EP300(26), HDAC1(1), LDB1(2), LEF1(2), TRRAP(10)	6415918	73	53	72	19	23	3	17	8	22	0	0.455	1.000	1.000
427	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(15), B3GALT4(4), CDR1(2), DGKI(5), FAU(2), IL6ST(3), MRPL19(1), PIGK(3), RPL10(2), RPL11(2), RPL13(1), RPL15(1), RPL23(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL36(1), RPL37(1), RPL3L(1), RPL4(3), RPL5(1), RPL6(1), RPL7(1), RPLP0(1), RPS13(1), RPS18(4), RPS27A(1), RPS4X(2), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), RPS7(1), RPS9(1), SLC36A2(1), TBC1D10C(1), UBA52(1), UBB(2)	10110488	88	53	88	35	46	4	19	10	9	0	0.863	1.000	1.000
428	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(4), EIF2AK1(2), EIF2AK2(2), EIF2AK3(3), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(9), EIF5A(1), EIF5B(6), ETF1(2), KIAA0664(4), PABPC3(3), PAIP1(7), SLC35A4(1)	8446237	69	53	68	22	35	2	12	9	11	0	0.833	1.000	1.000
429	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHDH(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1)	11033323	75	52	75	30	38	6	15	7	9	0	0.776	1.000	1.000
430	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2A(2), AMY2B(1), ENPP1(2), GAA(2), GANAB(8), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), MGAM(6), PGM1(2), PYGL(1), PYGM(4), SI(5), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2)	10951877	78	52	77	32	36	4	21	7	10	0	0.924	1.000	1.000
431	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), CPEB1(3), EGFR(3), ERBB2(11), ERBB4(3), ETS1(2), ETV6(4), ETV7(1), FMN2(7), MAP2K1(1), MAPK3(3), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), PIWIL1(4), PIWIL3(3), PIWIL4(4), RAF1(1), SOS1(5), SOS2(4), SPIRE2(3)	10112030	80	51	79	24	39	0	23	9	9	0	0.588	1.000	1.000
432	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY4(2), ADCY6(4), ADCY8(5), CACNA1A(6), CACNA1B(2), GNAS(4), GNB1(5), GNB3(3), GRM4(1), ITPR3(4), KCNB1(3), PDE1A(2), PLCB2(1), PRKACB(1), PRKX(1), SCNN1A(4), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS1R3(5), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R39(1), TAS2R40(2), TAS2R43(1), TAS2R50(3), TAS2R60(1), TAS2R9(3), TRPM5(4)	10962344	77	51	75	35	40	5	19	8	5	0	0.709	1.000	1.000
433	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), ESRRA(2), HNF4A(1), NR1D1(3), NR1D2(3), NR1H2(4), NR1I2(1), NR1I3(2), NR2C2(2), NR2F1(2), NR2F2(2), NR3C1(1), NR4A1(1), NR4A2(2), PGR(1), PPARD(1), PPARG(3), RARA(3), RARB(4), RARG(11), ROR1(2), RORA(1), RORC(2), RXRA(12), RXRG(5), VDR(1)	8105847	73	51	67	24	36	4	13	8	12	0	0.510	1.000	1.000
434	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT3(1), GSK3A(1), IL4R(1), IRS1(3), IRS2(3), JAK1(3), JAK3(3), MAP4K1(3), MAPK3(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PPP1R13B(3), RAF1(1), SOS1(5), SOS2(4), STAT6(3)	7102277	68	51	53	18	44	2	7	9	6	0	0.352	1.000	1.000
435	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(7), AXIN1(3), CCND1(1), CCND3(5), CSNK1E(1), CTNNB1(4), DVL2(2), DVL3(1), FOSL1(1), FZD10(1), FZD3(3), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LDLR(2), MAPK10(1), MAPK9(5), MYC(1), PAFAH1B1(1), PLAU(1), PPP2R5E(2), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), RHOA(5), SFRP4(2), WNT2(2), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1)	11623560	76	51	76	33	34	5	18	7	12	0	0.937	1.000	1.000
436	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), CASP6(1), CASP8(4), CFLAR(1), DAXX(1), DFFA(4), FADD(1), FAF1(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), PTPN13(7), RB1(19), RIPK2(1), SPTAN1(34)	7809634	101	50	99	33	49	5	12	5	30	0	0.931	1.000	1.000
437	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), HSD3B7(1), NSD1(7), OGDH(5), OGDHL(4), PIPOX(2), PLOD1(1), PLOD2(3), RDH13(1), SETD1A(3), SETDB1(4), SHMT1(1), TMLHE(1)	11209014	70	50	70	42	41	2	10	8	9	0	0.999	1.000	1.000
438	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DAK(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), GK2(3), GLA(1), GLB1(2), LCT(4), LIPA(1), LIPC(5), LIPG(2), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(4), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1)	11310718	79	50	79	30	46	3	14	7	9	0	0.646	1.000	1.000
439	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(1), BMP6(1), BMP8B(1), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK1G1(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(10), HHIP(4), IHH(2), LRP2(12), PRKACB(1), PRKX(1), PTCH1(8), PTCH2(1), RAB23(1), SMO(2), STK36(5), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), ZIC2(3)	11716731	82	50	82	34	31	3	31	5	12	0	0.891	1.000	1.000
440	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT3(1), ARHGEF11(3), DLG4(3), GNA13(5), LPA(7), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RDX(2), ROCK1(4), ROCK2(6), SERPINA4(1)	9477595	75	50	74	24	38	2	15	7	13	0	0.751	1.000	1.000
441	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), GHR(2), IRS1(3), MAPK14(1), MAPK3(3), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PRKCA(1), PTEN(5)	5453102	67	49	52	22	41	4	6	7	9	0	0.893	1.000	1.000
442	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(6), DAXX(1), EGF(4), EGFR(3), ETS1(2), FOS(3), HRAS(6), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), RAF1(1), RELA(2), RIPK1(2), SP1(3), TNFRSF1B(3), TRAF2(2)	9497857	75	49	74	32	31	4	23	8	9	0	0.921	1.000	1.000
443	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), CALM1(1), CALM2(1), CHRM1(1), FLT1(1), FLT4(1), KDR(9), NOS3(6), PDE2A(1), PDE3A(5), PDE3B(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKG1(1), PRKG2(4), RYR2(21), SLC7A1(4), SYT1(2), TNNI1(2)	7781154	71	49	71	31	34	2	18	7	10	0	0.923	1.000	1.000
444	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP3(1), CASP8(4), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MADD(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), RB1(19), RIPK1(2), SPTAN1(34), TRADD(1), TRAF2(2)	7466731	96	49	94	28	45	5	11	7	28	0	0.738	1.000	1.000
445	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADHA(3), KMO(1), MAOA(1), SDS(1), TDO2(1)	10636058	69	49	69	31	38	1	12	10	8	0	0.888	1.000	1.000
446	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT3(1), ASAH1(2), BRAF(1), DAG1(1), EGFR(3), EPHB2(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), RAF1(1), SOS1(5), SOS2(4), SRC(4), TERF2IP(2)	11325403	70	47	69	32	37	3	16	7	7	0	0.945	1.000	1.000
447	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT3(1), CISH(1), IL13RA1(1), IL2RG(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(2), JAK3(3), PIK3CA(26), PPP1R13B(3), SERPINA4(1), SOS1(5), SOS2(4), SRC(4), STAT6(3), TYK2(2)	7135316	65	47	50	22	49	2	7	6	1	0	0.657	1.000	1.000
448	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DFFA(4), FADD(1), GAS2(2), LMNA(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF10A(4), TNFRSF25(3), TNFSF10(2), TRADD(1), TRAF2(2)	6462866	81	46	81	22	47	1	14	3	16	0	0.505	1.000	1.000
449	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(4), ACTR3(1), CFL2(1), FLNA(5), FLNC(5), FSCN1(1), FSCN2(2), GDI1(2), LIMK1(2), MYH2(5), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PFN1(2), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1)	9282557	61	46	61	23	30	0	13	9	9	0	0.771	1.000	1.000
450	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(7), AXIN1(3), CCND1(1), CREBBP(18), CSNK1A1(3), CSNK2A1(4), CTBP1(1), CTNNB1(4), HDAC1(1), MAP3K7(3), MYC(1), NLK(2), PPARD(1), PPP2CA(1), TLE1(4), WIF1(2)	5669390	56	46	55	18	21	2	13	4	16	0	0.785	1.000	1.000
451	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), BCL2L1(2), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CD40(1), DAXX(1), DFFA(4), FADD(1), IKBKE(2), MCL1(1), NFKB1(1), NFKBIA(2), NGFR(3), NR3C1(1), NTRK1(4), PTPN13(7), RIPK1(2), SFRS2IP(2), TFG(4), TNFRSF1B(3), TRADD(1), TRAF2(2), TRAF6(1)	8380146	60	45	60	26	30	0	15	4	11	0	0.958	1.000	1.000
452	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), GLA(1), GLB1(2), LCT(4), LIPC(5), LIPG(2), LPL(1), PNLIP(3), PNLIPRP1(4), PPAP2A(5), PPAP2B(1), PPAP2C(1)	9288337	69	45	69	31	40	2	11	7	9	0	0.876	1.000	1.000
453	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT2(1), AGPAT3(2), AGPS(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CPT1B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), ETNK1(1), GPD1(1), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB2(1), PLCG1(3), PLCG2(3), PPAP2A(5), PPAP2B(1), PPAP2C(1)	9642734	70	45	70	31	38	3	14	7	8	0	0.886	1.000	1.000
454	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT4(4), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), B4GALT6(2), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1), UGCG(1)	9353394	66	45	66	21	35	2	15	9	5	0	0.282	1.000	1.000
455	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(19), BMPR1B(2), CDK4(2), CDKN1B(5), CEBPB(3), DAZL(1), DMC1(1), EGR1(1), FSHR(1), INHA(1), LHCGR(2), MLH1(4), MSH5(3), NCOR1(13), NRIP1(4), PGR(1), PRLR(1), PTGER2(1), SMPD1(3), VDR(1)	6741023	69	45	69	24	31	2	12	8	16	0	0.851	1.000	1.000
456	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(7), AXIN1(3), CCND1(1), CTNNB1(4), GJA1(1), GNAI1(1), LEF1(2), LY96(1), MYD88(1), NFKB1(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), RELA(2), TLR4(3), TOLLIP(1)	5945217	58	44	43	15	34	3	9	3	9	0	0.497	1.000	1.000
457	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(2), ARSD(2), CARM1(2), CYP11B2(3), HSD17B1(1), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), SULT2B1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), WBSCR22(3)	9664217	65	44	64	20	32	5	14	12	2	0	0.433	1.000	1.000
458	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CD4(1), CD8A(2), CIITA(2), CTSB(1), CTSL1(1), CTSS(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), HSP90AA1(8), HSP90AB1(4), HSPA5(1), IFNA16(1), IFNA4(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRC4(2), KLRD1(1), NFYA(1), PDIA3(3), PSME1(1), RFX5(1), RFXANK(1), TAP1(1), TAP2(1), TAPBP(1)	8924652	60	44	59	27	27	2	11	6	14	0	0.929	1.000	1.000
459	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), F10(1), F11(3), F12(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), PROS1(4), SERPINC1(1), SERPING1(1)	8526258	60	44	59	21	33	1	19	2	5	0	0.936	1.000	1.000
460	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(1), ALDOA(2), FBP1(1), FPGT(5), FUK(2), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LHPP(2), MPI(2), MTMR1(2), MTMR2(3), MTMR6(4), PFKFB1(2), PFKFB2(2), PFKFB3(3), PFKP(1), PGM2(1), PMM1(3), PMM2(1), RDH13(1), TSTA3(1)	7200946	56	43	56	24	37	1	7	3	8	0	0.757	1.000	1.000
461	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(6), ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), ATP7A(2), ATP7B(1), COX10(2), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX8A(1), NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRH(1)	7385928	63	43	61	16	31	4	16	7	5	0	0.217	1.000	1.000
462	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CDK5(1), FYN(1), GNAI1(1), GNB1(5), HRAS(6), JAK2(2), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPT(5), MYLK(5), PLCG1(3), PRKCA(1), PTK2B(3), RAF1(1), SOS1(5), STAT1(4), SYT1(2)	8045102	64	42	63	18	34	2	11	10	7	0	0.390	1.000	1.000
463	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(3), F12(1), F13B(1), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), LPA(7), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2), VWF(7)	6796099	51	42	51	15	28	1	16	2	4	0	0.524	1.000	1.000
464	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(3), CLDN5(1), CLOCK(1), CRY1(1), CRY2(3), DAZAP2(2), DNAJA1(1), EIF4G2(5), ETV6(4), GFRA1(2), GSTM3(1), GSTP1(2), HERPUD1(1), HSPA8(2), NCKAP1(5), NCOA4(2), NR1D2(3), PER1(3), PER2(1), PIGF(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(4), TUBB3(5), UGP2(5), VAPA(2), ZFR(1)	7043852	66	42	65	17	36	3	13	4	10	0	0.542	1.000	1.000
465	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHAL6A(1), LDHAL6B(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2)	9052196	50	42	49	21	27	0	10	3	10	0	0.871	1.000	1.000
466	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP1(1), ARHGAP5(8), ARHGAP6(4), ARHGEF1(6), ARHGEF11(3), ARHGEF5(2), ARPC2(3), ARPC4(1), DIAPH1(2), LIMK1(2), MYL2(2), MYLK(5), PFN1(2), PIP5K1A(5), PPP1R12B(2), ROCK1(4), SRC(4), TLN1(2), VCL(1)	8757657	60	42	60	15	37	0	11	5	7	0	0.285	1.000	1.000
467	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(7), ASAH1(2), DAG1(1), DLG4(3), EPHB2(3), GNAI1(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PTX3(1), RAC1(1), RYR1(12)	8882824	54	42	54	21	27	3	8	6	10	0	0.729	1.000	1.000
468	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(5), CDC7(1), CDK2(1), CDT1(2), DIAPH2(4), MCM10(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), RFC1(3), RFC4(4), RPA3(3), RPS27A(1), UBA52(1), UBB(2)	9800033	61	41	61	21	36	0	12	6	7	0	0.703	1.000	1.000
469	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), NT5E(3), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TYMS(1), UMPS(1), UPB1(3)	11097581	66	41	66	22	41	0	8	11	6	0	0.568	1.000	1.000
470	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(6), FOS(3), IKBKB(4), LY96(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TLR10(4), TLR2(2), TLR3(2), TLR4(3), TLR6(2), TLR7(6), TLR9(2), TOLLIP(1), TRAF6(1)	7040216	59	41	59	18	28	2	11	5	13	0	0.602	1.000	1.000
471	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS2(3), DARS(2), DARS2(3), EARS2(1), EPRS(5), FARSA(1), FARSB(2), GARS(1), IARS2(2), KARS(3), LARS(1), LARS2(1), MTFMT(1), NARS(1), NARS2(2), QARS(3), RARS(1), RARS2(2), SARS(2), SARS2(2), TARS2(8), VARS(3), VARS2(4), YARS(3), YARS2(1)	10493955	59	40	58	19	37	4	12	3	3	0	0.581	1.000	1.000
472	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLG2(3), POLH(2), POLI(2), POLK(6), POLM(2), POLQ(8), PRIM2(2), REV1(2), REV3L(10)	7805948	58	39	58	16	33	1	8	6	10	0	0.635	1.000	1.000
473	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ADCY3(2), ADCY9(3), ARF3(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), GNAS(4), PDIA4(1), PLCG1(3), PLCG2(3), PRKCA(1), SEC61A2(1), TRIM23(2)	7154229	50	39	50	17	26	3	8	6	7	0	0.544	1.000	1.000
474	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(13), ACAT1(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2)	7144639	45	39	45	21	25	0	9	2	9	0	0.947	1.000	1.000
475	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(4), EGFR(3), HRAS(6), MAP2K1(1), MAPK3(3), PTPRB(5), RAF1(1), RASA1(4), SOS1(5), SPRY1(1), SPRY4(2), SRC(4)	4817454	43	38	42	11	23	1	14	3	2	0	0.407	1.000	1.000
476	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(7), AXIN1(3), BMP4(1), BMP5(1), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(4), MAP3K7(3), MEF2C(2), MYL2(2), NOG(1), NPPB(1), RFC1(3), TGFB3(1), TGFBR2(3), TGFBR3(7)	7033970	50	37	50	17	29	0	8	4	9	0	0.823	1.000	1.000
477	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2)	9450979	48	37	48	32	27	0	11	3	7	0	0.997	1.000	1.000
478	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2)	9450979	48	37	48	32	27	0	11	3	7	0	0.997	1.000	1.000
479	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GALM(2), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6A(1), LDHAL6B(1), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2)	11262038	51	37	51	39	29	0	12	2	8	0	1.000	1.000	1.000
480	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(3), AKR1B10(1), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), HSD3B7(1), MAOA(1), PIPOX(2), PISD(2), PSAT1(1), PSPH(3), RDH13(1), SARS(2), SARS2(2), SDS(1), SHMT1(1), TARS2(8)	8242557	52	37	52	21	27	3	11	4	7	0	0.757	1.000	1.000
481	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(2), ALOX15(2), ALOX5(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2U1(1), CYP4A11(2), CYP4A22(4), CYP4F2(4), CYP4F3(2), EPHX2(2), GGT1(1), GPX3(2), GPX6(2), LTA4H(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3)	7513504	50	37	50	20	26	1	12	4	7	0	0.620	1.000	1.000
482	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), CSK(4), FYN(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MAPK8(4), PPP1R12B(2), PTK2(3), RAF1(1), RAP1A(1), ROCK1(4), SOS1(5), SRC(4), TLN1(2), VCL(1), ZYX(1)	9121297	56	37	55	20	35	3	11	4	3	0	0.724	1.000	1.000
483	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(2), CAMK2D(1), CAMK2G(3), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFAT5(7), PDE6A(1), PDE6B(1), PDE6C(2), PDE6G(1), PDE6H(1), SLC6A13(1)	6918933	44	37	44	16	24	3	8	3	6	0	0.685	1.000	1.000
484	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(1), ALDH4A1(1), CAD(7), CPS1(4), EARS2(1), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), GMPS(2), GNPNAT1(1), GSR(2), GSS(1), NADSYN1(3), NAGK(2), PPAT(2), QARS(3)	7640218	51	36	51	24	28	1	12	4	6	0	0.941	1.000	1.000
485	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ACY3(3), ADSL(1), ADSS(2), ASL(3), ASPA(2), ASRGL1(1), ASS1(2), CAD(7), CRAT(5), DARS(2), DARS2(3), DLAT(1), DLD(2), GAD1(5), NARS(1), NARS2(2), PC(2), PDHA2(2)	7322026	47	36	47	19	26	1	11	5	4	0	0.792	1.000	1.000
486	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(5), BLVRA(1), COX10(2), COX15(1), CP(1), EARS2(1), EPRS(5), FECH(1), FTH1(3), GUSB(1), HCCS(1), HMOX2(1), MMAB(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROD(1), UROS(2)	8101375	53	36	53	15	25	2	10	6	10	0	0.484	1.000	1.000
487	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BLNK(1), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP3K1(3), MAPK3(3), MAPK8IP3(3), PAPPA(4), RAC1(1), RPS6KA1(1), RPS6KA3(2), SOS1(5), SYK(1), VAV1(2), VAV2(1), VAV3(2)	6185886	41	36	40	14	20	0	14	5	2	0	0.665	1.000	1.000
488	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT3(1), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3)	8687058	54	36	54	25	30	2	11	2	9	0	0.928	1.000	1.000
489	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), COMT(2), DBH(3), DCT(3), DDC(3), GSTZ1(1), HPD(2), MAOA(1), TPO(9), TYR(3)	6114589	45	36	45	15	18	0	18	6	3	0	0.466	1.000	1.000
490	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), CALM1(1), CALM2(1), EGFR(3), HRAS(6), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MEF2A(1), MEF2C(2), MEF2D(1), PRKCA(1), PTK2(3), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2)	6461198	48	35	47	15	23	1	16	6	2	0	0.626	1.000	1.000
491	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(3), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), PON1(1)	5656467	53	35	52	26	31	2	8	5	7	0	0.863	1.000	1.000
492	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), HSD3B7(1), LIPA(1), RDH13(1), SLC27A5(4), SOAT1(4), SRD5A1(1), SRD5A2(1)	6119347	44	35	44	14	28	1	7	3	5	0	0.364	1.000	1.000
493	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(1), HMGN1(2), HRAS(6), HSPB2(2), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK14(1), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), RAC1(1), RIPK1(2), RPS6KA5(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2)	7067862	45	35	44	16	23	3	12	2	5	0	0.806	1.000	1.000
494	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH4A1(1), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), MAOA(1), NOS1(4), NOS3(6), ODC1(1), P4HA1(1), P4HA3(1), P4HB(3), PYCR1(3), RARS(1)	8547023	46	34	46	18	25	0	11	5	5	0	0.721	1.000	1.000
495	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(3), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CPT1B(2), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), MAOA(1), PISD(2), PLCB2(1), PLCG1(3), PLCG2(3), PSPH(3), SARS(2), SHMT1(1)	8106773	44	34	44	15	20	2	13	3	6	0	0.532	1.000	1.000
496	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B4GALT1(1), DHDDS(3), DOLPP1(1), DPM1(1), FUT8(5), GANAB(8), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), ST6GAL1(1)	8150046	55	34	55	17	31	0	8	10	6	0	0.417	1.000	1.000
497	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM1(1), CALM2(1), HRAS(6), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2)	5506811	43	34	42	12	22	2	10	6	3	0	0.469	1.000	1.000
498	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(2), CASP3(1), CREB5(5), DAG1(1), EPHB2(3), FOS(3), ITPKA(2), ITPKB(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5)	5514628	45	34	45	14	19	2	10	4	10	0	0.624	1.000	1.000
499	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANC(3), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LCT(4), MGAM(6), PFKP(1), PGM1(2), RDH13(1), UGP2(5)	7485376	43	33	42	25	25	1	7	4	6	0	0.966	1.000	1.000
500	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACAA2(1), ACAT1(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(3), DLD(2), EHHADH(1), HADH(1), HADHA(3), HADHB(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), OXCT2(1)	8323222	41	33	41	11	26	1	6	2	6	0	0.443	1.000	1.000
501	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2I(2), GTF2IRD1(2), TAF1(2), TAF10(1), TAF12(2), TAF13(1), TAF1L(3), TAF2(3), TAF4(4), TAF4B(2), TAF5(1), TAF6(2), TAF6L(1), TAF7L(3), TAF9(1), TAF9B(1)	6957108	40	33	40	14	24	0	8	2	6	0	0.879	1.000	1.000
502	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(4), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADHA(3), PLOD1(1), PLOD2(3), SDS(1), SHMT1(1), TMLHE(1)	7137961	45	33	45	29	27	1	5	5	7	0	0.998	1.000	1.000
503	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6B(1), MDH1(1), PC(2), PCK1(3), PDHA2(2), PDHX(1), PFKP(1), PGAM1(1), PKLR(1), PKM2(2), TNFAIP1(1)	8224739	39	32	39	29	20	0	12	1	6	0	0.999	1.000	1.000
504	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(1), ACO2(2), CLYBL(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), OGDH(5), OGDHL(4), PC(2), PCK1(3), SDHA(3), SDHC(2), SUCLG1(1)	5778893	41	32	41	27	21	2	9	4	5	0	0.997	1.000	1.000
505	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(3), ASS1(2), CKMT2(2), CPS1(4), EPRS(5), GATM(1), GLUD1(2), GLUD2(3), LAP3(1), NOS1(4), NOS3(6), P4HA1(1), P4HA3(1), PRODH(1), PYCR1(3), RARS(1), RARS2(2)	6953557	44	32	43	13	26	2	9	1	6	0	0.460	1.000	1.000
506	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CREB5(5), DUSP10(3), EEF2K(4), EIF4E(1), GADD45A(1), MAP2K3(2), MAP2K4(1), MAP3K10(1), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), MYEF2(2), NFKB1(1), NR2C2(2), TRAF6(1)	6452082	44	32	43	17	19	2	9	2	12	0	0.849	1.000	1.000
507	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(2), GPRC5A(1), GPRC5D(1), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM7(4), GRM8(1)	4053491	33	31	32	15	16	0	12	2	3	0	0.660	1.000	1.000
508	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(3), CHIT1(4), CMAS(1), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(4), GNPNAT1(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NAGK(2), RENBP(2), UAP1(1)	5545996	48	31	48	21	32	1	6	3	6	0	0.894	1.000	1.000
509	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BDH2(2), DDHD1(2), EHHADH(1), GAD1(5), HADH(1), HADHA(3), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(1), ILVBL(1), L2HGDH(1), OXCT2(1), PDHA2(2), PLA1A(2), PPME1(1), PRDX6(4), RDH13(1)	7845533	39	31	38	19	23	1	6	3	6	0	0.936	1.000	1.000
510	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(1), CNGB1(7), GNAL(1), GUCA1B(1), PDE1C(4), PRKACB(1), PRKG1(1), PRKG2(4), PRKX(1)	5889004	38	31	38	12	20	0	13	5	0	0	0.511	1.000	1.000
511	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL6(2), IRAK2(1), IRAK3(3), MAP2K3(2), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TGFB3(1), TOLLIP(1), TRAF6(1)	5728160	43	31	43	16	22	1	8	3	9	0	0.814	1.000	1.000
512	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(1), CREB5(5), DUSP4(1), DUSP6(3), EEF2K(4), EIF4E(1), MAP2K1(1), MAP3K8(2), MAPK3(3), MKNK1(1), MOS(2), NFKB1(1), RAP1A(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SOS1(5), SOS2(4)	5698715	42	31	41	13	25	2	6	3	6	0	0.673	1.000	1.000
513	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), DLG4(3), EPHB2(3), F2RL1(3), F2RL3(1), MAPK7(2), MAPK8(4), MYEF2(2), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RAF1(1), RASAL1(1), SRC(4), TEC(4), VAV1(2)	5299718	43	31	43	13	21	1	11	3	7	0	0.527	1.000	1.000
514	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(3), ACADSB(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SDS(1), UPB1(3)	5614107	36	30	36	13	18	0	9	6	3	0	0.675	1.000	1.000
515	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), AKR1D1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), SRD5A1(1), SRD5A2(1)	4481679	33	30	33	12	16	1	8	4	4	0	0.623	1.000	1.000
516	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANAB(8), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), LCT(4), MGAM(6), PFKP(1), PGM1(2)	6303677	40	30	40	20	20	1	8	3	8	0	0.903	1.000	1.000
517	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(2), CALCRL(2), CD97(3), CRHR2(1), EMR2(1), GHRHR(1), GIPR(1), GLP2R(1), GPR64(2), LPHN1(5), LPHN2(8), LPHN3(5), SCTR(3), VIPR1(1), VIPR2(4)	5135548	42	30	42	24	13	2	14	4	9	0	0.957	1.000	1.000
518	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), HSD3B7(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), RDH13(1)	4622175	34	30	34	14	19	0	4	3	8	0	0.698	1.000	1.000
519	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA2(2), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NAGLU(1), NEU2(2), NEU4(1), SPAM1(1)	6653859	37	30	37	11	21	1	7	5	3	0	0.384	1.000	1.000
520	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(2), F2RL3(1), GNAI1(1), GNB1(5), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), PLCB1(4), PRKCA(1), PTK2(3), RAF1(1), SRC(4), SYK(1), TBXAS1(3)	4709578	38	30	37	13	18	2	11	7	0	0	0.702	1.000	1.000
521	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(1), CASP3(1), CASP8(4), CFLAR(1), FADD(1), MAP2K4(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), NR2C2(2), RALBP1(1), RIPK1(2), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF2(2)	5270016	41	30	41	14	22	1	9	3	6	0	0.697	1.000	1.000
522	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CHUK(6), IKBKB(4), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TRADD(1), TRAF2(2)	4665487	39	30	39	13	20	3	6	3	7	0	0.661	1.000	1.000
523	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(6), EGF(4), EGFR(3), MET(5), PDGFRA(7), PRKCA(1), SH3KBP1(2), SRC(4)	3757386	36	29	36	12	18	1	11	5	1	0	0.649	1.000	1.000
524	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), EPOR(1), FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAPK3(3), MAPK8(4), PLCG1(3), RAF1(1), SOS1(5), STAT5B(2)	4154884	35	29	34	10	21	1	6	5	2	0	0.445	1.000	1.000
525	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(2), FBP1(1), FPGT(5), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), MPI(2), PFKFB1(2), PFKFB3(3), PFKP(1), PMM1(3), PMM2(1)	4624722	36	29	36	16	24	0	4	2	6	0	0.749	1.000	1.000
526	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), EP300(26), HIF1A(1), NOS3(6), P4HB(3)	3281496	37	29	37	11	14	2	5	6	10	0	0.771	1.000	1.000
527	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(4), PGAP1(2), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGW(1), PIGZ(1)	4592986	35	29	35	13	19	2	7	2	5	0	0.578	1.000	1.000
528	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX10(1), STX11(2), STX12(1), STX16(1), STX18(1), STX3(4), STX4(2), STX5(2), STX7(1), STX8(1), TSNARE1(3), USE1(1), VAMP4(1), VAMP5(1), VTI1B(3), YKT6(1)	3229386	34	29	34	12	23	0	6	3	2	0	0.661	1.000	1.000
529	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), CHRM1(1), CHRM3(4), CHRM4(1), DRD3(1), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1)	4935543	35	29	35	22	19	3	9	3	1	0	0.855	1.000	1.000
530	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(3), AP2M1(1), BIN1(1), CALM1(1), CALM2(1), DNM1(3), EPS15(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(3), SYNJ2(2), SYT1(2)	4214441	33	29	33	13	19	2	3	5	4	0	0.883	1.000	1.000
531	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(3), ERCC3(2), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2H1(2), MNAT1(1), POLR1A(5), POLR1B(1), POLR2B(1), POLR2C(2), POLR2E(1), POLR2F(1), POLR3B(3), POLR3E(2), POLR3H(1), TAF12(2), TAF13(1), TAF5(1), TAF6(2), TAF9(1)	6764726	39	29	39	14	22	1	5	3	8	0	0.809	1.000	1.000
532	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), ITGA1(1), ITGB1(1), ITGB3(2), PTK2(3), RAC1(1), SPTAN1(34), SRC(4), TLN1(2)	5519831	59	29	59	18	38	2	9	1	9	0	0.571	1.000	1.000
533	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(7), CPS1(4), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GLS(1), GLS2(1), GLUD1(2), GMPS(2), GSS(1), NADSYN1(3), PPAT(2), QARS(3)	6420899	40	28	40	19	22	1	8	4	5	0	0.935	1.000	1.000
534	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GCNT1(1), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(3)	6230638	31	28	31	16	19	2	4	4	2	0	0.964	1.000	1.000
535	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), FADD(1), IKBKB(4), IL1A(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TLR4(3), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF6(1)	4699938	38	28	38	11	19	0	9	1	9	0	0.589	1.000	1.000
536	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(2), ARSB(2), ARSD(2), CYP11B2(3), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2)	5258278	36	27	36	12	20	3	9	3	1	0	0.470	1.000	1.000
537	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), LDHAL6A(1), LDHAL6B(1), MCEE(1), MUT(1), SUCLG1(1)	7678824	33	27	32	14	21	0	3	3	6	0	0.848	1.000	1.000
538	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), ILVBL(1), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCDC(1), PPCS(2), UPB1(3), VNN1(1)	3345916	32	27	32	11	16	0	9	6	1	0	0.663	1.000	1.000
539	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(1), MRPS7(1), RPL10A(1), RPL11(2), RPL13(1), RPL22L1(1), RPL23A(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL37(1), RPL3L(1), RPL6(1), RPL7(1), RPS13(1), RPS18(4), RPS6(3), RPS7(1), RPS9(1)	4382331	34	27	34	21	23	1	9	1	0	0	0.957	1.000	1.000
540	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(5), C5(3), ICAM1(3), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELP(1), VCAM1(1)	4777049	29	27	29	12	17	1	8	2	1	0	0.801	1.000	1.000
541	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(3), HRAS(6), ITGA1(1), ITGB1(1), MAPK3(3), MYL2(2), MYLK(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTK2(3), TLN1(2)	6323151	42	27	41	15	22	2	13	3	2	0	0.676	1.000	1.000
542	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(1), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(1), EDNRA(1), EDNRB(2), PRL(2), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS2(2), S100A6(1), TBXAS1(3)	3977901	29	27	29	15	12	0	15	1	1	0	0.923	1.000	1.000
543	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(7), AXIN1(3), CTNNB1(4), DLL1(4), NOTCH1(5), PSEN1(5)	4134022	29	27	29	14	14	1	5	2	7	0	0.982	1.000	1.000
544	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), P4HB(3), SLC2A1(3), SLC2A3(4)	4799749	30	27	29	13	13	2	8	3	4	0	0.964	1.000	1.000
545	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), AGTR2(1), EDNRA(1), EDNRB(2), EGF(4), EGFR(3), FOS(3), HRAS(6), MYC(1), NFKB1(1), PLCG1(3), PRKCA(1), RELA(2)	3969332	30	26	29	11	14	1	12	1	2	0	0.656	1.000	1.000
546	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC3(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), DFFA(4), LMNA(1), LMNB1(2), LMNB2(1), PRF1(4)	3736459	27	26	27	12	14	0	7	2	4	0	0.923	1.000	1.000
547	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPS(2), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(5), PPAP2B(1), PPAP2C(1)	4483989	30	26	30	12	18	0	2	3	7	0	0.829	1.000	1.000
548	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(1), DLD(2), DLST(1), FH(3), IDH3B(2), MDH1(1), OGDH(5), PC(2), PDHA2(2), PDHX(1), PDK2(1), SDHA(3), SDHC(2), SUCLG1(1)	5487307	29	26	29	20	16	2	7	2	2	0	0.996	1.000	1.000
549	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(13), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), MCEE(1), MUT(1), SDS(1), SUCLG1(1)	6399478	30	26	30	17	21	0	2	2	5	0	0.983	1.000	1.000
550	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(1), HADHA(3), HADHB(2), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), SDS(1)	6960225	32	26	32	16	23	0	5	1	3	0	0.961	1.000	1.000
551	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(2), CTH(2), GGT1(1), LCMT2(1), MAT1A(2), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SCLY(1), WBSCR22(3)	4827465	26	25	25	10	13	3	3	5	2	0	0.702	1.000	1.000
552	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(3), ACP6(1), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHRS1(1), DHRS7(2), DHRSX(3), PON1(1), PON2(1)	3476482	35	24	34	17	18	2	7	1	7	0	0.891	1.000	1.000
553	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(2), BCHE(3), CES2(2), CYP3A4(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2)	4408319	30	24	30	11	17	2	6	3	2	0	0.566	1.000	1.000
554	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL4R(1), TGFB3(1)	3867274	27	24	27	11	10	1	9	4	3	0	0.757	1.000	1.000
555	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(1), SYT1(2)	3904632	30	24	30	12	13	2	5	6	4	0	0.791	1.000	1.000
556	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSL(1), ADSS(2), ASL(3), ASPA(2), CAD(7), CRAT(5), DARS(2), GAD1(5), NARS(1), PC(2)	5044734	31	23	31	14	17	0	6	5	3	0	0.838	1.000	1.000
557	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(4), CHAT(2), COMT(2), DBH(3), DDC(3), GAD1(5), HDC(2), MAOA(1), PAH(3), SLC18A3(1)	2779711	26	23	26	15	11	1	9	1	4	0	0.956	1.000	1.000
558	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(1), CD33(2), CD5(1), CD7(2), IFNG(1), IL12B(2), TLR2(2), TLR4(3), TLR7(6), TLR9(2)	3589504	25	23	25	10	12	1	6	2	4	0	0.639	1.000	1.000
559	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GPX6(2), GSR(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), OPLAH(1)	4255262	29	23	29	14	13	2	7	2	5	0	0.834	1.000	1.000
560	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(3), ACP6(1), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), RFK(1), TYR(3)	2905957	30	23	29	11	18	2	7	1	2	0	0.824	1.000	1.000
561	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCS(2), UPB1(3)	2693978	28	23	28	10	14	0	8	5	1	0	0.743	1.000	1.000
562	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR2(1), COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), REN(2)	4830988	26	21	25	11	9	0	10	2	5	0	0.965	1.000	1.000
563	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), PC(2), PCK1(3), SDHA(3), SUCLG1(1)	3984886	24	21	24	13	12	0	7	2	3	0	0.949	1.000	1.000
564	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(3), AP2M1(1), BTK(3), EEA1(6), GRASP(2), GSK3A(1), LYN(2), PDPK1(1), PFKP(1), PLCG1(3), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1)	4869144	28	21	28	11	17	0	6	4	1	0	0.738	1.000	1.000
565	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(19), CDC25A(1), CHEK1(1), MYT1(3), WEE1(2)	2657515	26	20	26	11	11	2	4	4	5	0	0.953	1.000	1.000
566	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2), TKTL1(3), TKTL2(1)	4707229	22	20	22	12	9	0	8	1	4	0	0.873	1.000	1.000
567	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), NDST2(1), NDST3(2), NDST4(2)	3985201	21	20	21	12	12	0	3	3	3	0	0.917	1.000	1.000
568	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(1), JAK1(3), JAK2(2), JAK3(3), STAT1(4), STAT5B(2), TYK2(2)	3562698	21	20	21	12	11	0	2	3	5	0	0.940	1.000	1.000
569	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), SELE(1), SELP(1)	3076178	20	20	20	11	13	0	5	2	0	0	0.941	1.000	1.000
570	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(2), EPRS(5), GARS(1), KARS(3), LARS(1), LARS2(1), NARS(1), QARS(3), RARS(1), SARS(2), YARS(3)	6194728	24	19	24	14	14	1	5	1	3	0	0.980	1.000	1.000
571	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GFPT1(1), GNE(4), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), RENBP(2), UAP1(1)	3278556	23	18	23	16	14	1	4	0	4	0	0.992	1.000	1.000
572	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), GAD1(5), HADHA(3), L2HGDH(1), PDHA2(2), SDS(1)	4989515	21	18	21	15	12	0	4	1	4	0	0.994	1.000	1.000
573	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), PGD(1)	3491974	23	18	23	12	13	1	4	0	5	0	0.846	1.000	1.000
574	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT2(3), B3GAT3(1), B4GALT7(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST7(1), CHSY1(2), DSE(2), UST(1), XYLT1(3), XYLT2(2)	2684031	21	18	21	10	12	1	3	3	2	0	0.758	1.000	1.000
575	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3E(1), CXCR3(1), ETV5(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), JAK2(2), MAPK14(1), MAPK8(4), STAT4(1), TYK2(2)	3598829	22	18	22	20	11	0	8	2	1	0	1.000	1.000	1.000
576	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHB1(4), FYN(1), ITGA1(1), ITGB1(1), L1CAM(2), LYN(2), RAP1B(2), SELP(1)	3053500	17	16	17	10	11	1	4	1	0	0	0.957	1.000	1.000
577	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(3), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELE(1)	2335119	16	16	16	8	10	0	4	2	0	0	0.892	1.000	1.000
578	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(1), CD3E(1), CD4(1), CXCR3(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), JAK2(2), STAT4(1), TYK2(2)	2835218	17	16	17	14	8	0	7	1	1	0	0.996	1.000	1.000
579	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(3), DNMT1(4), MTNR1A(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1)	2160318	19	15	19	13	7	1	9	1	1	0	0.912	1.000	1.000
580	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(1), ACO2(2), ACSS1(1), FH(3), IDH1(3), MDH1(1)	2571940	15	14	15	12	8	0	2	2	3	0	0.987	1.000	1.000
581	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(3), MDH1(1), OGDH(5), SDHA(3)	1818782	14	14	14	10	6	1	4	2	1	0	0.979	1.000	1.000
582	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(3), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), RFK(1), TYR(3)	1873311	18	14	17	10	10	1	6	0	1	0	0.964	1.000	1.000
583	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CAMKK2(3), SYT1(2)	2229297	14	13	14	10	7	0	2	1	4	0	0.982	1.000	1.000
584	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3), HK2(3), HK3(3), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(2)	2263142	14	13	14	11	9	0	2	1	2	0	0.987	1.000	1.000
585	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASRGL1(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), HAL(3)	4102451	20	13	20	10	9	1	7	0	3	0	0.934	1.000	1.000
586	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(2), NADSYN1(3), NNMT(1), NNT(1), NT5E(3), QPRT(2)	2810480	15	13	15	6	8	2	4	1	0	0	0.792	1.000	1.000
587	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(2), JAK3(3), MAPK3(3), TYK2(2)	2273441	13	13	13	11	7	0	2	3	1	0	0.990	1.000	1.000
588	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(1), CASP3(1), CASP9(3), DAXX(1), HSPB2(2), IL1A(1), MAPKAPK2(1)	2194483	13	12	13	10	6	2	3	0	2	0	0.988	1.000	1.000
589	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(3), ITGAL(2), ITGAM(3), ITGB2(3), SELE(1)	2005411	12	12	12	7	7	0	4	1	0	0	0.889	1.000	1.000
590	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ITPKA(2), PDE1A(2), PLCB1(4), PLCB2(1), PRL(2), TRH(1)	2143051	12	12	12	5	5	0	5	2	0	0	0.779	1.000	1.000
591	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3), HK2(3), HK3(3), IMPA1(1), PGM1(2)	1982881	12	12	12	10	8	0	2	0	2	0	0.990	1.000	1.000
592	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(2), PC(2), SLC25A1(1), SLC25A11(1)	1792284	11	11	11	11	8	0	2	0	1	0	0.991	1.000	1.000
593	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(2), CHKA(1), PCYT1A(1), PDHA2(2), SLC18A3(1)	1346557	11	10	11	10	3	1	7	0	0	0	0.988	1.000	1.000
594	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(3), CTH(2), LDHAL6A(1), LDHAL6B(1), SDS(1), SULT1C2(1), SULT1C4(2)	2426832	11	10	11	5	3	1	6	1	0	0	0.846	1.000	1.000
595	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CSK(4), PRKCA(1), PTPRA(1), SRC(4)	1788561	12	10	12	8	6	2	3	1	0	0	0.957	1.000	1.000
596	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(2), GPI(3), HK1(3), PGAM1(1), PKLR(1)	1800386	10	9	10	10	6	0	2	1	1	0	0.990	1.000	1.000
597	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), CHST12(1), SULT1A1(1), SULT2A1(1), SULT2B1(1), SUOX(1)	1787499	8	8	8	11	5	0	1	2	0	0	0.999	1.000	1.000
598	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), SDHA(3), SDHC(2)	1280620	7	7	7	6	4	1	2	0	0	0	0.985	1.000	1.000
599	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(2), APOBEC2(1), APOBEC4(1)	1417496	8	7	8	4	6	0	1	1	0	0	0.836	1.000	1.000
600	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1)	1461085	7	7	7	6	2	1	3	1	0	0	0.979	1.000	1.000
601	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(2), BMPR2(5)	1206668	8	7	8	5	8	0	0	0	0	0	0.948	1.000	1.000
602	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(3)	908261	6	6	6	5	4	0	1	1	0	0	0.987	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(2), HSD3B7(1), RDH13(1)	929465	5	5	5	5	4	1	0	0	0	0	0.933	1.000	1.000
604	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), LARS(1), LARS2(1), PDHA2(2)	1933941	5	5	5	3	3	0	2	0	0	0	0.933	1.000	1.000
605	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(1)	753607	4	4	4	4	2	0	1	1	0	0	0.969	1.000	1.000
606	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1)	964152	4	4	4	3	2	0	0	2	0	0	0.916	1.000	1.000
607	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), SULT2A1(1), SUOX(1)	1180420	4	4	4	8	2	0	1	1	0	0	1.000	1.000	1.000
608	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD3E(1), CD4(1)	620923	4	3	4	5	2	0	1	1	0	0	0.986	1.000	1.000
609	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(2)	1323441	2	2	2	3	0	1	1	0	0	0	0.986	1.000	1.000
610	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	351636	1	1	1	2	0	1	0	0	0	0	0.983	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	GSTZ1(1)	430986	1	1	1	3	1	0	0	0	0	0	0.994	1.000	1.000
612	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		318050	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3		509080	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		140554	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		98540	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		295672	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
