rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(11), GNB1(2), PRKACA(4), PRKAR1A(6)	8502224	28	26	28	3	9	3	4	5	7	0	0.0943	0.0426	1.000
2	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3), CD3G(3)	1706454	6	6	6	0	0	2	1	2	1	0	0.271	0.121	1.000
3	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(7), ESR2(5), ITPKA(1), PDE1A(5), PDE1B(5), PLCB1(13), PLCB2(7), TRH(1), VIP(1)	15482614	45	34	45	2	6	11	9	9	10	0	0.00166	0.230	1.000
4	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(1), GNB1(2), HTR2C(6), PLCB1(13), TUB(4)	10147428	30	25	30	3	8	5	4	7	6	0	0.0399	0.293	1.000
5	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(1), HGD(4)	3248696	8	8	8	1	1	1	2	3	1	0	0.395	0.304	1.000
6	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(4), GOT1(2), GOT2(1), TAT(3), TYR(5)	6774381	15	14	15	2	4	2	5	2	2	0	0.269	0.321	1.000
7	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(1)	2293210	6	6	6	1	0	0	3	2	1	0	0.591	0.336	1.000
8	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL10(3), BCL2L1(1), BCL2L11(5), BID(4), CASP9(3), CES1(4)	10857957	38	31	38	4	7	16	5	5	5	0	0.0362	0.398	1.000
9	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(5), MST1(7), MST1R(8)	8247485	21	17	20	2	4	8	4	2	3	0	0.0603	0.415	1.000
10	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(6), CDK7(3), MNAT1(2), SHH(1), XPO1(15)	12399459	36	30	35	3	8	17	4	2	5	0	0.0234	0.416	1.000
11	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	738841	1	1	1	0	0	0	0	1	0	0	0.800	0.422	1.000
12	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(1)	3040859	6	6	6	1	2	1	0	2	1	0	0.484	0.429	1.000
13	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(3), SPCS3(1)	4475834	9	9	9	0	1	5	3	0	0	0	0.0651	0.496	1.000
14	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), NFYC(4), SP1(6), SP3(7)	7095469	18	18	17	3	0	5	2	5	6	0	0.413	0.521	1.000
15	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3E(3), CD3G(3), CD4(4)	4747896	13	12	13	3	1	3	2	3	4	0	0.519	0.532	1.000
16	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(3), B3GALT2(2), B3GALT5(2), B3GNT5(4), FUT1(1), FUT3(3), ST3GAL3(5), ST3GAL4(2)	9401425	22	19	22	2	5	7	7	3	0	0	0.0385	0.557	1.000
17	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8)	7938257	13	13	13	1	2	4	1	4	2	0	0.138	0.571	1.000
18	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(3)	2941407	9	9	9	2	1	4	2	2	0	0	0.487	0.572	1.000
19	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(3), IL8(1), NFKB1(5), NOX1(5), RELA(3), SOD1(1), XDH(9)	14003534	31	30	31	2	5	9	3	7	7	0	0.0155	0.588	1.000
20	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIK(1), BIRC2(3), BIRC3(4), CASP3(1), CASP6(2), CASP7(2), CASP9(3), DFFA(4), DFFB(2), DIABLO(1)	17624863	45	33	44	2	4	20	7	3	11	0	0.00399	0.611	1.000
21	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), TFDP1(3)	7059391	15	15	14	3	4	3	2	1	5	0	0.516	0.634	1.000
22	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), STAT1(4)	11988633	26	24	26	2	2	5	6	5	8	0	0.0771	0.642	1.000
23	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	6722905	16	16	16	3	2	3	4	4	3	0	0.274	0.648	1.000
24	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(12), CD44(4), CSF1(5), FCGR3A(4), IL6R(5), SELL(6), SPN(2), TGFB1(2), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(4), TNFSF8(1)	18683248	52	39	50	6	9	13	5	13	12	0	0.0139	0.650	1.000
25	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	1046953	1	1	1	1	0	0	0	0	1	0	0.943	0.671	1.000
26	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2)	8274194	13	13	13	2	3	2	7	0	1	0	0.327	0.681	1.000
27	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(5), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B4(8), HSD17B7(1), HSD3B1(3), HSD3B2(4)	11635128	31	31	30	6	3	8	10	6	4	0	0.272	0.701	1.000
28	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(4), SNAP25(4), STX1A(3), VAMP2(1)	4601119	16	14	16	4	3	6	3	3	1	0	0.417	0.702	1.000
29	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1)	10292419	24	22	24	3	5	4	4	7	4	0	0.195	0.706	1.000
30	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(2), CD4(4), HLA-DRB1(10)	2582311	16	15	16	8	1	2	5	4	4	0	0.911	0.706	1.000
31	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1), TAT(3)	3780433	6	5	6	1	1	1	1	1	2	0	0.642	0.711	1.000
32	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HSD3B7(1), PON1(4), PON2(1), PON3(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	12737805	31	25	31	4	1	9	5	12	4	0	0.0581	0.718	1.000
33	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CCNE1(2), CDK2(2), CKS1B(1), CUL1(2), E2F1(5), SKP2(2), TFDP1(3)	9332326	17	17	16	3	4	5	2	2	4	0	0.415	0.727	1.000
34	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(3), PNMT(1), TH(2), TPH1(3)	7961250	15	13	15	2	5	4	2	1	3	0	0.190	0.744	1.000
35	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CDK2(2), CDK4(1), CHEK1(2), MYT1(10), WEE1(4)	21895875	52	47	51	6	5	18	5	10	14	0	0.0822	0.755	1.000
36	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CHEK1(2), MYT1(10), WEE1(4)	20080255	49	44	48	6	5	18	5	9	12	0	0.105	0.761	1.000
37	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(3), CD3G(3), CXCR3(6), ETV5(9), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), JAK2(7), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(8), TYK2(8)	27009540	74	61	72	10	12	18	11	17	16	0	0.0299	0.768	1.000
38	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(5), LRP8(6), RELN(26), VLDLR(9)	20116514	49	38	47	4	9	12	14	7	6	1	0.00616	0.769	1.000
39	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RELA(3)	11773653	29	24	29	4	6	4	5	5	9	0	0.154	0.788	1.000
40	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	2285289	3	3	3	1	0	1	1	0	1	0	0.761	0.789	1.000
41	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), SKP2(2), TFDP1(3)	9880734	17	17	16	3	4	5	2	1	5	0	0.401	0.802	1.000
42	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(10), BAIAP2(2), CASP1(3), CASP3(1), CASP7(2), GAPDH(1), INSR(11), ITCH(4), MAGI1(17), MAGI2(9), RERE(13), WWP1(6), WWP2(12)	31661231	91	60	88	9	12	34	13	23	8	1	0.000541	0.803	1.000
43	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(3), UGDH(1), UGP2(4), UXS1(3)	7314842	14	13	14	2	2	7	3	1	1	0	0.287	0.817	1.000
44	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(2), SULT1A2(2), SULT1E1(4), SUOX(4)	8879120	16	14	16	2	3	3	4	4	2	0	0.278	0.832	1.000
45	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(1)	2463299	4	4	4	2	0	0	0	2	2	0	0.916	0.856	1.000
46	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(8), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(5), NFKBIA(3), RELA(3)	13249927	29	25	29	3	10	9	4	1	5	0	0.0601	0.863	1.000
47	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(2), ACP5(3), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), RFK(1), TYR(5)	14072621	39	33	38	6	8	8	11	6	6	0	0.0839	0.864	1.000
48	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(2), HLA-DRB1(10), IL3(1)	3487909	14	13	14	6	1	2	4	4	3	0	0.863	0.868	1.000
49	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(5), ALDOB(3), ALDOC(2), TPI1(2)	5543262	13	13	13	3	2	7	1	2	1	0	0.375	0.874	1.000
50	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4)	8041021	15	14	15	3	3	4	2	4	2	0	0.370	0.874	1.000
51	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(3), UGDH(1), UXS1(3)	5788071	10	9	10	2	2	4	3	1	0	0	0.476	0.875	1.000
52	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(3), GLS(5), GLUD1(2), OAT(2), PRODH(2)	7874276	17	13	17	2	2	5	2	3	5	0	0.276	0.879	1.000
53	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(2), CFTR(14), GNAS(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(3)	17760037	50	38	50	8	13	9	8	8	12	0	0.0875	0.880	1.000
54	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), CREM(3), FHL5(3), FSHR(9), GNAS(11), XPO1(15)	12897294	46	37	45	9	11	10	9	10	6	0	0.314	0.882	1.000
55	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(5), CARS2(5), CDO1(3), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4), SULT1B1(2), SULT1C2(2), SULT1C4(1), SULT4A1(2)	17542811	33	31	33	4	2	13	4	3	11	0	0.0970	0.884	1.000
56	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(4), NDUFA13(1)	6022984	8	8	8	0	1	3	2	2	0	0	0.132	0.887	1.000
57	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(7), JAK3(8), MAPK1(1), MAPK3(1), STAT3(5), TYK2(8)	16414334	41	35	39	6	9	5	9	7	11	0	0.118	0.892	1.000
58	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(2), MYC(1), SP1(6), SP3(7), WT1(4)	8581979	25	23	24	5	5	6	2	6	6	0	0.382	0.903	1.000
59	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(1), NR3C1(3), PPARG(5), RXRA(2)	7579786	14	14	13	3	3	2	4	2	3	0	0.452	0.912	1.000
60	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8)	14824682	38	34	36	6	4	4	12	8	10	0	0.229	0.915	1.000
61	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8)	14824682	38	34	36	6	4	4	12	8	10	0	0.229	0.915	1.000
62	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CDO1(3), CSAD(6), GAD1(3), GAD2(3), GGT1(4)	8090557	24	22	24	5	4	10	4	2	4	0	0.270	0.922	1.000
63	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4)	5971765	14	13	14	4	4	3	2	3	2	0	0.545	0.924	1.000
64	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	7663375	14	14	14	3	2	3	4	4	1	0	0.447	0.924	1.000
65	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(5), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4)	9359890	18	16	18	3	1	6	3	2	6	0	0.324	0.924	1.000
66	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(2), CD4(4), HLA-DRB1(10), IL4(1)	4893098	17	16	17	9	1	2	5	4	5	0	0.958	0.928	1.000
67	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(23), ATR(13), CDC25C(6), CHEK1(2), CHEK2(6)	21964219	50	43	49	7	6	17	5	10	12	0	0.178	0.928	1.000
68	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12832568	32	30	31	6	4	12	8	5	3	0	0.116	0.929	1.000
69	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12832568	32	30	31	6	4	12	8	5	3	0	0.116	0.929	1.000
70	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(4), CHUK(8), IFNG(2), IKBKB(6), IL4(1), JUN(3), MAP3K5(12), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF9(2), TNFSF9(1), TRAF2(1)	24396614	56	44	55	8	14	15	7	4	16	0	0.0727	0.930	1.000
71	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), OXCT1(5)	4916287	8	6	8	2	1	4	0	3	0	0	0.572	0.932	1.000
72	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(6), ALAS2(8), HMBS(3), PPOX(6), UROD(2), UROS(2)	11213226	27	23	26	5	4	6	6	7	4	0	0.298	0.934	1.000
73	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(3), HLA-A(3), IL18(2), ITGB1(5), KLRC1(5), KLRC3(1), KLRD1(1), LAT(1), MAP2K1(5), MAPK3(1), PAK1(4), PTK2B(7), PTPN6(2), SYK(4), VAV1(6)	21524409	50	45	49	7	6	14	10	14	6	0	0.0497	0.935	1.000
74	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(5), CBS(1), CTH(3), MUT(3)	6896259	13	13	13	3	2	3	2	2	4	0	0.524	0.937	1.000
75	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(2), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), E2F1(5), HRAS(2), MAPK1(1), MAPK3(1), NFKB1(5), NFKBIA(3), PAK1(4), RAF1(4), RELA(3), TFDP1(3)	20136632	42	38	41	6	12	9	5	7	9	0	0.0651	0.942	1.000
76	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(4), CPS1(12), GLS(5), GLUD1(2), GOT1(2)	11110445	28	23	28	5	1	5	11	6	5	0	0.318	0.944	1.000
77	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	22	ATF1(3), CASP2(3), CHUK(8), IKBKB(6), JUN(3), LTA(2), MAP2K3(3), MAP2K6(1), MAP4K2(2), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFRSF1A(4), TRAF2(1)	28576328	59	48	58	6	12	18	9	7	13	0	0.00492	0.950	1.000
78	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(6), ALAS2(8), GATA1(2), HBA2(2), HBB(1), HMBS(3), UROD(2), UROS(2)	11907873	26	22	25	5	5	6	5	6	4	0	0.308	0.951	1.000
79	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(1), FUT3(3), FUT5(2), FUT6(3), ST3GAL3(5)	6000163	14	14	14	4	4	3	4	2	1	0	0.472	0.952	1.000
80	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), PGM1(5), PGM3(2), TGDS(3)	14547260	29	25	29	4	4	4	6	11	4	0	0.0883	0.957	1.000
81	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), IMPA2(4), ISYNA1(1), PGM1(5), PGM3(2), TGDS(3)	16286781	34	29	34	5	6	4	7	12	5	0	0.0722	0.957	1.000
82	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), HRAS(2), JUN(3), MAP2K1(5), MAPK1(1), MAPK3(1), MYC(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RAF1(4), RELA(3)	21335411	46	38	46	6	10	10	5	10	11	0	0.0439	0.959	1.000
83	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TPO(8), TYR(5)	13818300	38	35	38	8	8	8	7	8	7	0	0.244	0.960	1.000
84	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(11), ATM(23), BAX(3), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(5), MDM2(3), TIMP3(3)	22211464	55	46	54	9	9	15	5	9	17	0	0.242	0.963	1.000
85	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), UGDH(1)	11889086	18	18	17	2	4	3	4	2	5	0	0.144	0.969	1.000
86	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(3), FARSB(5), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4), YARS2(1)	12532648	26	20	26	4	3	11	3	5	4	0	0.211	0.970	1.000
87	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(4), LCT(17), MPI(2), PGM1(5), PYGL(3), PYGM(5), TPI1(2), TREH(2)	19328590	43	39	43	8	8	7	8	11	9	0	0.137	0.972	1.000
88	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(3), CDKN1A(1), CHEK1(2), NEK1(6), WEE1(4)	11028581	20	18	20	3	3	10	0	1	6	0	0.515	0.977	1.000
89	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), E2F1(5), RBL1(6), TFDP1(3)	19043618	41	38	40	7	6	8	9	5	12	1	0.253	0.978	1.000
90	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(1), BIRC3(4), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	8859192	17	15	16	4	4	7	3	0	3	0	0.465	0.981	1.000
91	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(11), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4)	13298783	33	29	33	6	6	8	6	4	9	0	0.317	0.982	1.000
92	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(2), IFNG(2), IFNGR1(2), IKBKB(6), JAK2(7), LIN7A(1), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF1A(4), TNFRSF1B(2), USH1C(8), WT1(4)	21245296	49	37	48	7	11	15	6	4	13	0	0.0413	0.982	1.000
93	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	CASP3(1), CFL1(1), CFLAR(1)	3763315	3	3	3	1	0	0	1	1	1	0	0.772	0.983	1.000
94	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), EPO(1), EPOR(4), GRIN1(3), HIF1A(4), JAK2(7), NFKB1(5), NFKBIA(3), RELA(3)	17959980	35	31	35	5	6	13	3	4	9	0	0.118	0.983	1.000
95	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(5), B4GALT1(3), B4GALT3(2), B4GALT5(4), DDOST(2), DPAGT1(4), DPM1(4), FUT8(2), MAN1A1(6), MAN1B1(3), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), RPN1(4), RPN2(2), ST6GAL1(3)	26640907	61	44	61	9	8	19	14	10	9	1	0.0346	0.986	1.000
96	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), DPM2(1), EGR1(3), HRAS(2), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(4)	11221001	26	24	25	5	4	7	3	7	5	0	0.241	0.986	1.000
97	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(7), ALOX15(4), ALOX15B(5), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(4), LTA4H(2), PLA2G2A(1), PLA2G6(2), PTGDS(4), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3)	21297488	52	41	52	8	10	11	13	9	9	0	0.0340	0.987	1.000
98	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(1), FBL(4), GPT(2), LDHA(3), LDHC(4), MAPK14(2), NCL(7)	13000130	31	27	31	6	5	10	8	4	4	0	0.283	0.988	1.000
99	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(2), CFL1(1), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), LIMK1(8), MAP2K1(5), MAPK1(1), MAPK3(1), NOX1(5), PIK3C2G(8), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2(7), RAF1(4), ROCK2(9)	36460410	89	68	87	10	14	21	14	18	22	0	0.0124	0.989	1.000
100	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(6), BMPR2(8)	8792759	18	16	17	7	1	2	4	5	6	0	0.893	0.990	1.000
101	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(1), CYP11B2(4), CYP17A1(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	9789566	23	22	22	6	2	7	6	6	2	0	0.322	0.991	1.000
102	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), PLA2G2A(1), PTPRU(10), REG1A(1), STAT1(4)	16457271	40	35	40	8	5	7	9	8	10	1	0.352	0.991	1.000
103	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(2), FARS2(4), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4)	11950977	20	15	20	3	3	5	5	5	2	0	0.216	0.992	1.000
104	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(11), ARHGAP5(12), ARHGDIB(1), CASP1(3), CASP10(2), CASP3(1), CASP9(3), JUN(3), PRF1(2)	16739655	38	30	38	6	5	9	6	4	14	0	0.271	0.992	1.000
105	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(2)	11740592	20	20	19	4	2	9	3	5	1	0	0.322	0.993	1.000
106	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(8), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1)	14612241	27	24	27	5	3	10	6	6	2	0	0.258	0.993	1.000
107	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(2), CCND1(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CFL1(1), E2F1(5), MDM2(3), PRB1(3)	9422780	20	20	19	5	5	1	2	3	9	0	0.671	0.994	1.000
108	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(11), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP7(2), CASP9(3), DFFA(4), DFFB(2), PRF1(2), SCAP(2), SREBF1(4), SREBF2(6)	23236410	46	35	45	7	5	19	10	2	10	0	0.0863	0.994	1.000
109	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(2), GRIA2(4)	5072210	8	8	8	3	3	3	2	0	0	0	0.695	0.994	1.000
110	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(1), BCMO1(5), RDH5(1)	5555924	11	10	11	9	2	1	3	1	4	0	0.995	0.995	1.000
111	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2L6(2), UBE3A(3)	14852819	27	25	27	5	3	7	7	4	6	0	0.352	0.995	1.000
112	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(5), GLUD1(2), GLUD2(3)	6372372	10	9	10	3	3	1	1	2	3	0	0.776	0.995	1.000
113	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PNPO(2), PSAT1(1)	6829010	10	9	10	3	2	2	2	1	3	0	0.660	0.996	1.000
114	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(3), PRKCA(4), TGM2(7)	6992505	15	13	15	7	3	4	1	1	6	0	0.857	0.996	1.000
115	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(1), CTH(3), GGT1(4), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(2), PAPSS2(2), SCLY(4), SEPHS1(2)	17363140	37	29	36	7	9	8	9	5	6	0	0.109	0.996	1.000
116	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(3), CSF1(5), CSF3(2), EPO(1), IL11(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1)	8721905	22	20	22	6	3	7	4	1	7	0	0.513	0.996	1.000
117	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(2), COMT(1), DBH(6), DDC(4), GAD1(3), GAD2(3), MAOA(2), PAH(3), PNMT(1), SLC18A3(3), TH(2), TPH1(3)	19286564	37	34	37	6	11	7	7	5	7	0	0.0923	0.996	1.000
118	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(4), DFFB(2), HMGB1(2), HMGB2(3), TOP2A(3), TOP2B(6)	15293450	23	17	22	2	0	10	3	5	5	0	0.162	0.996	1.000
119	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(5), CAP1(3), CCNB1(3), CDC25C(6), GNAI1(2), GNAS(11), GNB1(2), HRAS(2), MAPK1(1), MAPK3(1), MYT1(10), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RPS6KA1(7), SRC(1)	28232840	72	59	71	12	17	17	12	9	16	1	0.0586	0.996	1.000
120	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(3), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(6), RAB9A(1)	6236461	18	15	18	5	1	6	5	2	3	1	0.635	0.996	1.000
121	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	12	AKT1(2), CREB1(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(5), RELA(3), SP1(6)	16144074	33	32	33	6	6	12	6	7	2	0	0.159	0.996	1.000
122	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GLS(5), GLUD1(2), GLUL(3), GMPS(5), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSS(3), NADSYN1(6), PPAT(5), QARS(10)	47656764	112	79	112	16	10	39	23	21	19	0	0.00417	0.996	1.000
123	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(12), AGT(3), AGTR1(4), AGTR2(2), BDKRB2(4), KNG1(4), NOS3(3), REN(1)	13588029	33	29	33	8	7	10	5	7	4	0	0.273	0.997	1.000
124	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	19212154	35	31	34	6	7	6	13	3	6	0	0.151	0.997	1.000
125	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), MTMR1(1), MTMR2(2), MTMR6(3), RFK(1), TYR(5)	21704622	47	38	46	8	9	12	12	7	7	0	0.115	0.997	1.000
126	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(11), ARHGDIB(1), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), DFFA(4), DFFB(2), LMNA(4), LMNB1(2), LMNB2(3), PRF1(2)	25575901	53	40	52	8	5	18	11	6	13	0	0.156	0.997	1.000
127	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(3), CD3E(3), CD3G(3), CD4(4), CD58(2), CD8A(3), CSF3(2), IL3(1), IL6(2), IL8(1), KITLG(3)	9035804	31	27	31	9	2	10	6	4	9	0	0.588	0.998	1.000
128	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(3), B4GALT3(2), B4GALT5(4), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2)	10964043	23	21	23	5	3	10	5	3	2	0	0.341	0.998	1.000
129	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(5), FOS(1), JUN(3), MAPK14(2), THBS1(8)	10269807	20	16	19	8	3	1	2	6	8	0	0.954	0.998	1.000
130	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA2(4), CCND1(1), CCNE1(2), CCNE2(4), CDK2(2), CDK4(1), CDKN2A(1), E2F1(5), E2F4(2), PRB1(3)	11609259	25	22	24	6	5	6	3	3	8	0	0.513	0.998	1.000
131	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(7), SQLE(2)	4783862	18	17	17	5	4	7	3	1	3	0	0.673	0.998	1.000
132	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), NFKB1(5), NFKBIA(3), RELA(3), TNFAIP3(3), TRAF3(3), TRAF6(4)	22633155	48	37	48	9	8	14	7	6	12	1	0.174	0.998	1.000
133	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), CD86(6), HLA-DRB1(10), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), IL2RA(2), IL4(1), IL4R(6)	17605712	50	42	50	11	4	11	13	16	6	0	0.300	0.998	1.000
134	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), CHST1(4), CHST2(5), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2)	15861121	35	31	35	7	9	9	8	5	4	0	0.174	0.998	1.000
135	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(4), ATG7(5), GABARAP(2), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3C3(6), PIK3R4(10), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(6), ULK3(5)	30206756	82	62	82	13	6	35	17	18	6	0	0.0385	0.998	1.000
136	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(4), HADHA(3)	7027296	8	8	8	3	0	2	3	2	1	0	0.798	0.998	1.000
137	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	17	BAD(1), BAX(3), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(5), NSMAF(3), RAF1(4), RELA(3), RIPK1(5), SMPD1(2), TNFRSF1A(4), TRAF2(1)	21713310	40	31	39	5	9	15	3	4	9	0	0.0316	0.998	1.000
138	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(8), MAPK14(2), MAPK8(2), NFKB1(5), RELA(3), TNFRSF13B(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	20720942	35	32	35	5	7	9	5	4	9	1	0.132	0.999	1.000
139	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(4), CREBBP(15), DFFA(4), DFFB(2), GZMA(2), HMGB2(3), PRF1(2)	15283074	34	29	33	7	6	8	5	7	8	0	0.355	0.999	1.000
140	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(2), PTK2B(7), SHC1(2), SOS1(5), SRC(1)	12346233	19	19	19	4	5	4	4	3	3	0	0.391	0.999	1.000
141	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CASP9(3), CHUK(8), GHR(5), NFKB1(5), NFKBIA(3), PDPK1(2), PPP2CA(3), RELA(3)	14675502	35	27	35	7	9	12	5	2	7	0	0.290	0.999	1.000
142	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(11), BID(4), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), DFFA(4), DFFB(2), GAS2(3), LMNA(4), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1)	45481112	88	61	87	8	18	30	16	7	17	0	0.000804	0.999	1.000
143	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3E(3), CD3G(3), IFNG(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4), TOB1(2)	15467259	31	28	31	7	6	8	4	9	4	0	0.380	0.999	1.000
144	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(11), STAT1(4), STAT3(5), STAT5A(6)	17086057	38	33	38	8	5	8	9	9	7	0	0.228	0.999	1.000
145	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(4), CD3E(3), CD3G(3), CD4(4), CXCR3(6), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), JAK2(7), STAT4(8), TYK2(8)	21397280	59	48	57	12	8	12	11	14	14	0	0.256	0.999	1.000
146	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(13), PLCG1(8), PRKCA(4), VAV1(6)	13131429	33	29	33	7	8	4	5	7	9	0	0.360	0.999	1.000
147	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(2), AKT1(2), ANXA1(5), CALM2(2), GNAS(11), GNB1(2), NFKB1(5), NOS3(3), NPPA(1), NR3C1(3), RELA(3), SYT1(2)	19334392	41	36	41	7	11	10	5	7	8	0	0.202	0.999	1.000
148	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(3)	19214893	34	31	33	6	4	12	5	8	4	1	0.230	0.999	1.000
149	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(2), IL22RA1(4), IL22RA2(3), JAK1(11), JAK2(7), JAK3(8), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), TYK2(8)	26016034	64	55	62	11	14	11	13	10	16	0	0.0683	1.000	1.000
150	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), PON1(4), PON2(1), PON3(4)	25301573	54	39	53	9	7	16	9	18	4	0	0.0450	1.000	1.000
151	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD1(9), PSMD11(3), PSMD12(3), PSMD13(2), PSMD2(2), PSMD6(3)	23377388	44	38	43	6	6	22	5	6	5	0	0.0647	1.000	1.000
152	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(2), ACAT1(3), HADHA(3)	7607691	9	9	9	3	1	3	2	3	0	0	0.702	1.000	1.000
153	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(5), CPT1A(6), CPT2(5), EHHADH(4), HADHA(3), SCP2(1), SLC25A20(4)	24001555	42	31	42	7	8	9	10	9	6	0	0.0947	1.000	1.000
154	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(2), FOS(1), JUN(3), KEAP1(3), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(3), PRKCA(4)	12277885	21	20	21	7	5	4	2	2	7	1	0.825	1.000	1.000
155	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(7), ATM(23), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(6), JUN(3), MAPK8(2), MDM2(3), MRE11A(8), NFKB1(5), NFKBIA(3), RAD50(6), RAD51(2), RBBP8(5), RELA(3), TP73(2)	40544887	95	82	94	13	13	34	8	15	25	0	0.0610	1.000	1.000
156	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNG(2), IL12B(2), IL15(3), IL16(7), IL18(2), IL1A(1), IL3(1), IL4(1), IL6(2), IL8(1), LTA(2)	13775870	25	21	25	6	3	7	5	7	3	0	0.424	1.000	1.000
157	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(7), CDKN2A(1), E2F1(5), MDM2(3), MYC(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), TBX2(1), TWIST1(2)	18342307	40	38	40	9	7	9	4	9	11	0	0.407	1.000	1.000
158	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(2), NR1I3(2), PTGS1(5), PTGS2(5)	7597151	16	14	16	6	3	3	3	3	4	0	0.765	1.000	1.000
159	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), FOS(1), HRAS(2), IL3(1), IL3RA(3), JAK2(7), MAP2K1(5), MAPK3(1), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	25078782	48	45	48	8	10	13	6	9	10	0	0.0602	1.000	1.000
160	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12B(2), IL18(2)	4479603	9	9	9	4	1	1	1	5	1	0	0.878	1.000	1.000
161	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(8), CDK5(2), CDK5R1(1), CSNK1A1(4), GSK3B(2), MAPT(4), PPP2CA(3)	13265528	33	27	33	7	5	11	5	6	6	0	0.330	1.000	1.000
162	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(15), EP300(13), ESR1(7), MAPK1(1), MAPK3(1), PELP1(7), SRC(1)	21312407	45	38	45	8	8	9	8	11	9	0	0.171	1.000	1.000
163	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), MAPK1(1), RAF1(4), SNX13(5), SRC(1), TERF2IP(3)	16710165	30	29	30	6	6	8	5	8	3	0	0.309	1.000	1.000
164	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(7), IDI2(1), SQLE(2)	6354231	21	17	20	6	4	10	3	1	3	0	0.689	1.000	1.000
165	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(8), PRKCA(4), PTK2B(7)	9584224	20	19	20	7	5	5	3	2	5	0	0.733	1.000	1.000
166	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(7), ADC(2), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EARS2(3), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GFPT2(9), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), GMPS(5), GNPNAT1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSR(4), GSS(3), NADSYN1(6), NAGK(2), PPAT(5), QARS(10)	56813849	137	93	136	21	14	44	27	27	25	0	0.00336	1.000	1.000
167	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(4), HEXA(3), HEXB(3), LCT(17), ST3GAL1(2), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1)	22850437	48	43	48	10	7	13	10	11	7	0	0.196	1.000	1.000
168	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(5), FH(3), IDH1(5), MDH1(1), SDHB(2), SUCLA2(1)	12982631	21	19	21	5	4	5	3	6	3	0	0.375	1.000	1.000
169	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	ABAT(7), ADSL(3), ADSS(3), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), CAD(17), CRAT(8), DARS(4), DDO(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), PC(10)	34053846	82	62	82	14	11	22	25	10	14	0	0.0176	1.000	1.000
170	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(2), GNAS(11), PLCE1(15), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAP2B(2)	20191676	50	44	50	10	12	8	11	7	12	0	0.247	1.000	1.000
171	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(1), JAK1(11), STAT1(4), STAT2(5), TYK2(8)	15405586	32	29	30	8	4	4	8	7	9	0	0.587	1.000	1.000
172	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(4), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PCYT1A(2), PCYT1B(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	19599052	60	48	60	12	6	21	14	9	9	1	0.169	1.000	1.000
173	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	22	ATM(23), BMPR1B(6), CCND2(3), CDK4(1), DAZL(1), DMC1(2), EGR1(3), ESR2(5), FSHR(9), GJA4(1), INHA(5), LHCGR(10), MLH1(7), MSH5(7), NR5A1(1), NRIP1(10), PGR(6), PRLR(4), PTGER2(2), SMPD1(2), ZP2(4)	40487914	112	81	110	20	17	26	19	22	28	0	0.0774	1.000	1.000
174	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(2), GBA3(4), LPO(4), MPO(5), TPO(8)	11984083	27	25	27	7	7	7	2	6	5	0	0.415	1.000	1.000
175	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	20773267	58	45	58	12	6	22	12	8	9	1	0.147	1.000	1.000
176	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(5), ERBB3(19), NRG1(4), UBE2D1(1)	14745332	34	30	32	8	4	7	12	7	4	0	0.415	1.000	1.000
177	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), PC(10), PDHA1(2), SLC25A1(2), SLC25A11(2)	13008135	28	25	28	8	4	3	10	5	6	0	0.508	1.000	1.000
178	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), PGD(4)	25942568	51	39	50	9	6	12	11	15	7	0	0.0891	1.000	1.000
179	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), DRD1(1), DRD2(3), GRM1(9), PLCB1(13), PPP2CA(3), PPP3CA(5), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	22591539	52	38	52	10	8	16	10	8	10	0	0.0897	1.000	1.000
180	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(2), CAT(2), GHR(5), HRAS(2), IGF1R(7), SHC1(2), SOD1(1)	13109118	21	17	21	5	4	8	3	3	3	0	0.372	1.000	1.000
181	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(4), SRP19(1), SRP54(1), SRP68(3), SRP72(2), SRPR(8)	10924324	20	18	19	5	1	6	1	8	4	0	0.547	1.000	1.000
182	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(4), ACOX3(5), ELOVL5(5), ELOVL6(4), FADS1(4), FADS2(7), FASN(14), HADHA(3), SCD(1)	19479458	48	41	48	11	4	18	11	7	8	0	0.147	1.000	1.000
183	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(14), RANGAP1(3)	12199976	18	16	18	4	1	7	2	3	5	0	0.766	1.000	1.000
184	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(1), CAMK1G(5), HDAC9(5), MEF2A(6), MEF2C(4), MEF2D(3)	11826597	24	21	24	7	1	5	4	9	5	0	0.613	1.000	1.000
185	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), PRKCA(4), PTPRA(6), SRC(1)	13161000	24	23	24	6	4	9	2	4	5	0	0.493	1.000	1.000
186	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(5), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), PC(10), PCK1(5), SDHB(2), SUCLA2(1), SUCLG2(1)	29730045	48	38	48	9	9	14	10	11	4	0	0.0705	1.000	1.000
187	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), BAD(1), CHRNB1(2), CHRNG(2), MUSK(10), PTK2(7), PTK2B(7), SRC(1), TERT(2)	17858218	34	27	34	8	8	9	5	7	5	0	0.270	1.000	1.000
188	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	IL4(1), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(5), NFATC2(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	13972134	31	29	31	9	4	10	8	3	6	0	0.420	1.000	1.000
189	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(2), HRAS(2), MAPK1(1), MAPK3(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NTRK1(8), PLCG1(8), RPS6KA1(7), SHC1(2)	22226215	50	41	49	10	12	10	5	14	9	0	0.149	1.000	1.000
190	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CCL2(1), CSF1(5), IL6(2), LDLR(6), LPL(1)	7488100	18	18	18	6	4	6	4	2	2	0	0.644	1.000	1.000
191	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST8SIA1(1)	13856861	23	21	23	6	3	9	3	5	3	0	0.498	1.000	1.000
192	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(6), AASDHPPT(4), AASS(5)	10159845	15	13	15	5	2	5	3	2	3	0	0.827	1.000	1.000
193	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(4), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(1), SIRT7(4), VNN2(7)	17016995	35	33	35	9	6	13	9	5	2	0	0.487	1.000	1.000
194	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(14), NRG2(4), NRG3(7), PRKCA(4), PSEN1(2)	13134990	31	28	31	8	1	11	6	8	5	0	0.596	1.000	1.000
195	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8222642	20	19	20	8	7	3	0	6	4	0	0.862	1.000	1.000
196	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8222642	20	19	20	8	7	3	0	6	4	0	0.862	1.000	1.000
197	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(8), CREBBP(15), EP300(13), HDAC3(1), IKBKB(6), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	31273743	69	53	68	11	16	16	10	10	17	0	0.0598	1.000	1.000
198	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(2), CALCRL(3), CD97(9), CRHR1(3), CRHR2(1), ELTD1(10), EMR1(5), EMR2(9), GHRHR(5), GIPR(1), GLP1R(2), GLP2R(4), GPR64(9), LPHN1(4), LPHN2(11), LPHN3(8), VIPR1(2), VIPR2(4)	39701150	96	76	96	21	12	27	19	17	20	1	0.0804	1.000	1.000
199	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), LTA(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFAIP3(3), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3)	28232837	59	43	59	11	11	17	12	5	13	1	0.0969	1.000	1.000
200	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3G(3)	10659633	17	14	17	5	4	4	4	2	3	0	0.639	1.000	1.000
201	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(4), AASS(5)	6933326	9	8	9	5	2	3	2	1	1	0	0.938	1.000	1.000
202	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(5), AKT3(4), BPNT1(2), ILK(3), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PTK2B(7), SHC1(2), SOS1(5)	24082803	40	37	40	8	8	10	6	7	9	0	0.236	1.000	1.000
203	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	11262296	22	20	21	8	5	3	6	2	6	0	0.779	1.000	1.000
204	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	11262296	22	20	21	8	5	3	6	2	6	0	0.779	1.000	1.000
205	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), BDH1(1), HMGCS1(6), HMGCS2(3), OXCT1(5), OXCT2(5)	10438872	23	17	21	7	5	8	1	7	2	0	0.639	1.000	1.000
206	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL2L1(1), BCL2L11(5), BID(4), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), CHUK(8), DFFA(4), DFFB(2), FAS(1), FASLG(2), HELLS(3), IKBKB(6), IRF1(2), IRF2(1), IRF3(6), IRF4(2), IRF5(2), IRF6(3), IRF7(1), JUN(3), LTA(2), MAPK10(4), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PLEKHG5(2), PRF1(2), RELA(3), RIPK1(5), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TP73(2), TRAF1(2), TRAF2(1), TRAF3(3)	71154305	151	99	150	19	26	50	24	17	32	2	0.000426	1.000	1.000
207	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(5), CBS(1), CTH(3), GGT1(4), HEMK1(2), LCMT1(1), LCMT2(10), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(4), METTL6(1), PAPSS1(2), PAPSS2(2), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(4), SEPHS1(2), SEPHS2(3), WBSCR22(2)	34674337	88	63	87	17	16	26	21	10	14	1	0.0378	1.000	1.000
208	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(6), AOC3(3), CES1(4), ESD(2)	8180767	16	12	16	7	1	3	7	4	1	0	0.825	1.000	1.000
209	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(6), NR0B2(2), NR1H3(2), NR1H4(4), RXRA(2)	7274062	17	17	17	8	6	4	2	4	1	0	0.871	1.000	1.000
210	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), PER1(10)	11816993	24	19	24	7	2	9	4	6	3	0	0.729	1.000	1.000
211	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), ADSS(3), IMPDH1(2), POLB(1), POLD1(5), POLG(7), PRPS2(1), RRM1(4), SRM(4)	17643206	30	27	29	8	7	7	7	1	7	1	0.589	1.000	1.000
212	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(2), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST8SIA1(1)	14706593	25	23	25	7	5	10	2	5	3	0	0.529	1.000	1.000
213	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(4), ADORA3(1), P2RY1(4), P2RY2(1), P2RY6(1)	7780486	14	13	14	6	5	0	6	3	0	0	0.667	1.000	1.000
214	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8), PPT1(1), PPT2(3)	11907818	23	20	23	7	4	10	6	2	1	0	0.593	1.000	1.000
215	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACYP1(2), EHHADH(4), GCDH(2), HADHA(3), SDHB(2)	11260298	16	15	16	5	2	6	3	5	0	0	0.612	1.000	1.000
216	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(3), NFS1(1), THTPA(3), TPK1(2)	9205688	12	11	12	5	2	7	1	1	1	0	0.907	1.000	1.000
217	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), GPD2(3), NDUFA1(2), SDHB(2), SDHD(1), UQCRC1(1)	9409288	13	12	13	5	3	1	2	6	1	0	0.772	1.000	1.000
218	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(4), IL11(1), IL1A(1), IL3(1), IL6(2), KITLG(3), TGFB1(2), TGFB2(1), TGFB3(1)	12163100	19	19	19	8	5	2	5	4	3	0	0.850	1.000	1.000
219	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(2), CHKA(1), PCYT1A(2), PDHA1(2), PDHA2(4), PEMT(1), SLC18A3(3)	9255670	18	16	18	6	5	3	4	4	2	0	0.632	1.000	1.000
220	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(2), CHST11(1), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT1A2(2), SULT1E1(4), SULT2B1(2), SUOX(4)	12337622	20	18	20	8	5	4	4	4	3	0	0.868	1.000	1.000
221	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF11A(2), TRAF6(4)	15288700	21	21	21	8	5	4	3	4	5	0	0.825	1.000	1.000
222	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(1), ALPP(3), ALPPL2(2), FPGS(4), GCH1(1)	8298532	11	10	11	5	4	1	3	2	1	0	0.770	1.000	1.000
223	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(2), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTR(5), SRM(4), TAT(3)	29374078	61	50	60	13	11	15	13	10	10	2	0.163	1.000	1.000
224	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(4), ACO2(5), ACSS1(1), ACSS2(2), FH(3), IDH1(5), MDH1(1), SUCLA2(1)	19205318	31	26	31	9	4	6	9	7	5	0	0.509	1.000	1.000
225	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(9), CREB1(2), EDN1(5), EP300(13), EPO(1), HIF1A(4), JUN(3), LDHA(3), NOS3(3), P4HB(2)	24022612	49	39	49	10	4	12	11	10	12	0	0.427	1.000	1.000
226	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(5), PGAP1(10), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGW(3), PIGZ(3)	35444282	61	47	61	11	8	19	14	14	6	0	0.0383	1.000	1.000
227	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL2RG(2), IL4(1), IL4R(6), IRS1(4), JAK1(11), JAK3(8), RPS6KB1(4), SHC1(2), STAT6(8)	19962253	48	38	48	11	5	13	12	8	9	1	0.308	1.000	1.000
228	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(5), CTSD(1), ESR1(7), GREB1(6), MTA3(2), PDZK1(1), TUBA8(1)	14243092	23	22	23	7	5	9	3	2	4	0	0.455	1.000	1.000
229	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(2), F2R(4), F5(26), F7(2), FGA(7), FGB(1), FGG(7), PROC(3), PROS1(4), SERPINC1(6), TFPI(4)	23248233	71	57	71	16	9	21	18	15	8	0	0.299	1.000	1.000
230	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(2), ACAT1(3), EHHADH(4), HADHA(3), HADHB(3)	12158591	16	16	16	5	2	4	5	4	1	0	0.628	1.000	1.000
231	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(7), BST1(3), CD38(3), ENPP1(7), ENPP3(6), NADK(1), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT12(2)	30216915	67	54	67	14	7	19	13	17	11	0	0.184	1.000	1.000
232	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	21657730	45	40	45	11	5	17	8	8	7	0	0.380	1.000	1.000
233	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(3), CA12(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUL(3), HAL(7)	27192974	57	49	57	12	6	12	17	11	11	0	0.224	1.000	1.000
234	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	23	ARHGDIB(1), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CFLAR(1), DAXX(2), DFFA(4), DFFB(2), FAF1(7), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), PTPN13(16), RIPK2(2), SPTAN1(13)	52256832	102	71	101	15	14	30	18	18	22	0	0.0469	1.000	1.000
235	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(5), FURIN(3), NOTCH1(8), PSEN1(2)	11132308	18	17	18	6	4	1	8	2	3	0	0.720	1.000	1.000
236	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), COMT(1), DBH(6), DCT(4), DDC(4), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HGD(4), HPD(4), MAOA(2), MAOB(4), PNMT(1), TAT(3), TH(2), TPO(8), TYR(5)	43642420	99	74	98	21	24	18	25	16	16	0	0.0825	1.000	1.000
237	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), NAT1(2), XDH(9)	11669208	23	20	23	9	4	4	5	7	3	0	0.815	1.000	1.000
238	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), TXNDC12(1)	28918353	57	44	56	10	6	12	14	15	10	0	0.0717	1.000	1.000
239	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(3), GFPT1(3), GNE(5), GNPDA2(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), PGM3(2), UAP1(3)	24432148	40	35	40	9	7	13	5	11	4	0	0.258	1.000	1.000
240	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(2), ARSB(3), ARSE(4), ASAH1(1), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(2), SPTLC1(4), SPTLC2(6), UGCG(1)	32137678	65	52	63	14	14	17	11	18	5	0	0.131	1.000	1.000
241	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(5), ATP6V0C(1), CAT(2), EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), SHMT1(1), SHMT2(4), TPO(8)	16839445	42	37	42	11	11	9	5	8	9	0	0.380	1.000	1.000
242	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TAT(3), TPO(8)	30125091	73	54	72	17	16	14	12	16	15	0	0.212	1.000	1.000
243	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(23), ATR(13), BRCA1(14), CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), CDC34(1), CDKN1A(1), CHEK1(2), CHEK2(6), EP300(13), MDM2(3), MYT1(10), PRKDC(24), RPS6KA1(7), WEE1(4)	61317892	134	106	132	22	17	37	20	25	35	0	0.0873	1.000	1.000
244	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR7(4), CD28(2), CD4(4), CXCR3(6), CXCR4(3), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18R1(4), IL4(1), IL4R(6), TGFB1(2), TGFB2(1), TGFB3(1)	29252883	65	47	65	17	6	14	13	21	11	0	0.375	1.000	1.000
245	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(1), CNR2(1), DNMT1(11), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1)	14353833	20	18	20	9	5	4	4	3	3	1	0.755	1.000	1.000
246	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS2(5), ABAT(7), ACY3(3), ADSL(3), ADSS(3), ADSSL1(1), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), ASS1(1), CAD(17), CRAT(8), DARS(4), DARS2(2), DDO(1), DLAT(2), DLD(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), NARS2(2), PC(10), PDHA1(2), PDHA2(4), PDHB(1)	50778275	106	80	106	19	18	26	31	13	18	0	0.0217	1.000	1.000
247	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), CASP3(1), CASP6(2), CASP7(2), CASP9(3), EIF2S1(3), PRKCA(4), PTK2(7), STAT1(4), TLN1(16)	38409307	87	67	86	17	12	33	10	12	20	0	0.187	1.000	1.000
248	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(7), ALOX15(4), ALOX5(3), CBR1(3), CYP4F2(3), CYP4F3(3), EPX(4), GGT1(4), LPO(4), LTA4H(2), MPO(5), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(3), PRDX2(1), PRDX5(4), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3), TPO(8)	39598131	96	71	96	18	18	23	19	19	17	0	0.0279	1.000	1.000
249	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), MDH1(1), OGDH(7), SUCLA2(1)	13832182	19	17	19	7	2	7	4	3	3	0	0.725	1.000	1.000
250	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), CA1(3), CA12(1), CA13(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), HAL(7)	30311351	61	53	61	13	8	13	17	12	11	0	0.215	1.000	1.000
251	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	26861042	60	51	60	15	12	19	10	10	9	0	0.278	1.000	1.000
252	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(6), CRK(1), CXCR4(3), GNAI1(2), GNAQ(1), GNB1(2), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), NFKB1(5), PIK3C2G(8), PLCG1(8), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), RELA(3)	34407455	70	57	69	13	15	20	8	15	11	1	0.0955	1.000	1.000
253	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTR(5)	24734248	51	40	50	12	10	13	9	9	8	2	0.262	1.000	1.000
254	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(5), AKT3(4), CDKN1A(1), ELK1(4), HRAS(2), MAP2K1(5), MAP2K2(2), NGFR(1), NTRK1(8), PIK3CD(6), SHC1(2), SOS1(5)	19075377	47	42	47	12	9	11	8	10	9	0	0.318	1.000	1.000
255	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(3), FAS(1), FASLG(2), JUN(3), MAPK10(4), MCL1(1), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), PARP1(6), PRF1(2), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1)	44134847	88	61	87	15	17	32	15	7	17	0	0.0396	1.000	1.000
256	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(8), IKBKB(6), IL1A(1), IL1R1(1), IRAK1(5), MAP3K7(3), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TLR4(15), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	29712189	69	51	67	14	12	20	11	11	15	0	0.147	1.000	1.000
257	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	23	AKT1(2), AKT2(5), AKT3(4), BAD(1), GSK3A(5), GSK3B(2), IL4R(6), IRS1(4), JAK1(11), JAK3(8), MAP4K1(10), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PPP1R13B(4), RAF1(4), SHC1(2), SOS1(5), SOS2(6), STAT6(8)	43541066	97	75	97	19	15	22	18	20	21	1	0.0754	1.000	1.000
258	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(5), CAT(2), EPX(4), LPO(4), MPO(5), MTHFR(6), SHMT1(1), SHMT2(4), TPO(8)	16454255	39	32	39	10	11	11	3	7	7	0	0.323	1.000	1.000
259	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(11), JAK2(7), JAK3(8), PIAS1(3), PIAS3(3), PTPRU(10), REG1A(1), SOAT1(2)	19634327	47	39	47	11	9	9	11	7	10	1	0.387	1.000	1.000
260	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(4), MMP9(3), RECK(2), TIMP1(2), TIMP3(3)	10797328	20	17	20	9	4	6	3	6	1	0	0.861	1.000	1.000
261	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), JAK1(11), JAK3(8), JUN(3), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	33067979	75	61	75	15	15	16	13	16	15	0	0.0932	1.000	1.000
262	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	18	AKT1(2), BCR(3), CRKL(1), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), MYC(1), RAF1(4), SOS1(5), STAT1(4), STAT5A(6), STAT5B(5)	28412331	52	49	52	10	11	13	5	13	10	0	0.147	1.000	1.000
263	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(15), EP300(13), IL2RG(2), IL7(1), IL7R(4), JAK1(11), JAK3(8), LCK(2), NMI(2), PTK2B(7), STAT5A(6), STAT5B(5)	34669884	76	59	76	15	15	16	14	15	16	0	0.126	1.000	1.000
264	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABARAP(2), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GPHN(5), NSF(3), SRC(1), UBQLN1(2)	17314468	49	40	49	13	9	18	9	9	4	0	0.374	1.000	1.000
265	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), HRAS(2), IGF1R(7), IRS1(4), MAP2K1(5), MAPK1(1), MAPK3(1), RAF1(4), SHC1(2), SOS1(5)	20630531	34	30	34	9	4	13	4	8	5	0	0.529	1.000	1.000
266	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(3), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5E(6)	20917447	46	39	46	12	5	14	8	11	8	0	0.452	1.000	1.000
267	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), IDS(3), IDUA(1), LCT(17), NAGLU(2)	20176770	47	42	47	13	8	13	7	13	6	0	0.511	1.000	1.000
268	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TAL1(1), TALDO1(2), TKT(3)	27853212	58	45	56	14	10	13	8	16	11	0	0.265	1.000	1.000
269	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(2), IL6R(5), JAK1(11), JAK2(7), JAK3(8), PIAS3(3), PTPRU(10), REG1A(1), SRC(1), STAT3(5)	21566510	55	43	55	13	10	7	13	11	13	1	0.362	1.000	1.000
270	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	23	ARHGDIB(1), BAG4(1), CASP2(3), CASP3(1), DFFA(4), DFFB(2), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MADD(15), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TRAF2(1)	46683370	97	70	95	17	17	28	19	14	19	0	0.0715	1.000	1.000
271	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(4), GNAI1(2), GNB1(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(13), PRKCA(4), PTGS1(5), PTK2(7), RAF1(4), SRC(1), SYK(4), TBXAS1(3)	34813315	78	55	78	15	14	19	19	18	8	0	0.0928	1.000	1.000
272	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(11), CASP3(1), CASP9(3), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(2)	15453534	27	22	27	9	4	11	5	3	3	1	0.737	1.000	1.000
273	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), GCK(3), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(4), MPI(2), PFKFB3(4), PFKFB4(3), PFKM(8), PFKP(7), PMM1(2), SORD(2), TPI1(2)	34500029	69	55	67	16	12	13	10	22	12	0	0.195	1.000	1.000
274	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BET1L(1), BNIP1(1), GOSR1(2), SNAP23(2), SNAP25(4), SNAP29(1), STX10(3), STX11(2), STX12(1), STX16(1), STX17(3), STX19(3), STX2(3), STX3(3), STX4(3), STX6(4), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP2(1), VAMP3(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(1), VTI1B(2)	23398571	56	50	56	13	9	18	11	6	12	0	0.290	1.000	1.000
275	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(8), ELK1(4), FOS(1), IKBKB(6), IRAK1(5), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), PPARA(4), RELA(3), TIRAP(1), TLR10(3), TLR2(3), TLR3(7), TLR4(15), TLR7(9), TLR9(2), TRAF6(4)	46739982	99	77	98	20	16	30	16	16	21	0	0.0969	1.000	1.000
276	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(4), EPO(1), EPOR(4), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	30754287	65	57	65	14	15	19	5	11	15	0	0.181	1.000	1.000
277	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD8A(3), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	15051669	39	32	39	12	3	12	10	8	6	0	0.532	1.000	1.000
278	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(10), GABBR1(3), GPRC5A(1), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM7(4), GRM8(5)	27403867	57	49	57	15	14	15	13	8	7	0	0.134	1.000	1.000
279	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(6), CALM2(2), CRKL(1), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(4), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2)	35113951	68	58	68	14	13	20	8	13	13	1	0.162	1.000	1.000
280	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL6(2), IL6R(5), IL6ST(9), JAK1(11), JAK2(7), JAK3(8), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(1), RAF1(4), SHC1(2), SOS1(5), SRF(1), STAT3(5)	33507537	79	61	79	17	13	14	16	18	18	0	0.219	1.000	1.000
281	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(1), GLI2(12), GLI3(11), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SHH(1), SMO(5), SUFU(3)	21773272	58	47	58	16	12	17	11	8	10	0	0.387	1.000	1.000
282	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(23), ATR(13), BRCA1(14), BRCA2(17), CHEK1(2), CHEK2(6), FANCA(8), FANCC(4), FANCD2(10), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(8), RAD1(1), RAD17(3), RAD50(6), RAD51(2), RAD9A(1)	62462060	128	99	127	21	14	52	12	23	27	0	0.110	1.000	1.000
283	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), BCL2L1(1), CASP9(3), CHUK(8), ELK1(4), HRAS(2), MAP2K1(5), MAPK3(1), NFKB1(5), RAF1(4), RALA(1), RALBP1(3), RALGDS(2), RELA(3), RHOA(6)	21954724	51	43	50	13	13	16	5	11	6	0	0.364	1.000	1.000
284	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(11), BAD(1), BAX(3), BCL2A1(1), BCL2L1(1), BCL2L2(1), BOK(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), CD40(2), CD40LG(1), DAXX(2), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKE(6), LTA(2), MCL1(1), NFKB1(5), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(8), PTPN13(16), RIPK1(5), TFG(2), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3), TRAF6(4)	59760785	118	77	116	22	16	39	19	18	25	1	0.0597	1.000	1.000
285	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(8), APAF1(11), ARHGDIB(1), BAG4(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), DAXX(2), DFFA(4), DFFB(2), GSN(2), LMNA(4), LMNB1(2), LMNB2(3), MAP2K7(1), MAP3K5(12), MAPK8(2), MDM2(3), NFKB1(5), NFKBIA(3), NUMA1(8), PAK2(2), PRKCD(5), PRKDC(24), PSEN1(2), PSEN2(4), PTK2(7), RASA1(2), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1)	90767435	181	122	178	27	37	50	33	26	35	0	0.00243	1.000	1.000
286	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), NAGLU(2), SPAM1(4)	28945867	71	62	72	19	12	21	10	17	11	0	0.419	1.000	1.000
287	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), OCRL(8), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8)	60950092	136	96	135	26	22	40	19	23	31	1	0.0470	1.000	1.000
288	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(5), FADS2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2)	14918453	35	30	35	10	2	12	10	9	2	0	0.511	1.000	1.000
289	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA3(3), ANXA4(3), ANXA5(1), ANXA6(5), CYP11A1(1), EDN1(5), EDNRA(3), EDNRB(2), HPGD(1), HSD11B1(3), HSD11B2(2), PLA2G4A(7), PTGDR(2), PTGDS(4), PTGER2(2), PTGER4(1), PTGFR(1), PTGIS(4), PTGS1(5), PTGS2(5), S100A6(1), TBXAS1(3)	29076974	69	50	69	17	12	20	9	16	12	0	0.334	1.000	1.000
290	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(15), DUSP1(1), EP300(13), IKBKB(6), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MYD88(1), NFKB1(5), NFKBIA(3), NR3C1(3), RELA(3), TGFBR1(4), TGFBR2(4), TLR2(3)	42126209	79	59	79	16	16	19	11	13	20	0	0.176	1.000	1.000
291	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(5), HRAS(2), INSR(11), IRS1(4), JAK2(7), MAP2K1(5), MAPK1(1), MAPK3(1), PLCG1(8), PRKCA(4), PTPN6(2), RAF1(4), RPS6KA1(7), SHC1(2), SLC2A4(3), SOS1(5), SRF(1), STAT5A(6), STAT5B(5)	40921998	83	66	82	17	14	29	6	13	21	0	0.117	1.000	1.000
292	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(3), GOT1(2), GOT2(1), LAP3(3), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), PARS2(2), PRODH(2), PYCR1(1), PYCR2(2), PYCRL(1), RARS(5), RARS2(3)	50673716	110	80	109	22	22	30	34	13	11	0	0.0391	1.000	1.000
293	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(2), AGMAT(4), ALDH18A1(4), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CPS1(12), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(3), SAT1(3), SAT2(2), SRM(4)	41605856	85	61	84	19	9	15	27	20	14	0	0.158	1.000	1.000
294	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(3), CHIT1(3), CMAS(3), CTBS(1), CYB5R1(4), GFPT1(3), GFPT2(9), GNE(5), GNPDA2(2), GNPNAT1(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(3), NAGK(2), NANS(1), NPL(2), PGM3(2), UAP1(3)	41264196	75	57	74	16	11	24	13	16	11	0	0.184	1.000	1.000
295	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	23510977	20	17	20	6	1	8	1	7	2	1	0.747	1.000	1.000
296	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(3), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MPL(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), THPO(3)	37493833	72	61	72	15	14	17	8	16	17	0	0.224	1.000	1.000
297	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	DUSP1(1), GORASP1(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PIK3CD(6), SYT1(2), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	38421184	62	53	62	13	16	13	9	12	11	1	0.155	1.000	1.000
298	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4B(2), EIF4G1(9), EIF4G2(2), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4), TSC1(5), TSC2(8)	32778571	62	51	61	13	12	26	6	10	8	0	0.247	1.000	1.000
299	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	35	AKT1(2), ATF2(4), DLD(1), DUSP10(9), DUSP4(1), GAB1(2), GCK(3), IL1R1(1), JUN(3), MAP2K5(1), MAP2K7(1), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK10(4), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(9), NR2C2(2), PAPPA(13), SHC1(2), TRAF6(4), ZAK(6)	64273135	136	96	134	26	22	28	18	26	42	0	0.0998	1.000	1.000
300	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(3), ALDOC(2), DERA(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKL(1), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TALDO1(2), TKT(3), TKTL1(3), TKTL2(3)	33744267	66	51	64	17	10	14	10	17	15	0	0.351	1.000	1.000
301	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(2), DLD(1), DLST(3), FH(3), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(10), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PDK1(2), PDK2(1), PDK4(4), PDP2(2), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1)	40969682	63	50	63	14	14	15	14	15	5	0	0.129	1.000	1.000
302	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT1(3), ACSM1(4), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), BDH1(1), DDHD1(4), EHHADH(4), GAD1(3), GAD2(3), HADH(2), HADHA(3), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), ILVBL(5), L2HGDH(2), OXCT1(5), OXCT2(5), PDHA1(2), PDHA2(4), PDHB(1), PLA1A(3), PPME1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	58178755	123	91	120	28	21	32	24	29	17	0	0.106	1.000	1.000
303	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(4), BCR(3), BLNK(1), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8IP3(8), PAPPA(13), RPS6KA1(7), RPS6KA3(8), SHC1(2), SOS1(5), SYK(4), VAV1(6), VAV2(3), VAV3(7)	40548007	94	69	93	22	20	21	16	20	17	0	0.199	1.000	1.000
304	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(5), AKT3(4), CISH(2), IARS(8), IL13RA1(1), IL2RG(2), IL4(1), IL4R(6), INPP5D(4), JAK1(11), JAK2(7), JAK3(8), NR0B2(2), PI3(1), PPP1R13B(4), RPS6KB1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT6(8), TYK2(8)	48886681	106	83	104	23	17	23	21	19	24	2	0.187	1.000	1.000
305	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(15), EEF1A2(3), EEF1B2(2), EEF1D(3), EEF1G(1), EEF2(5), EEF2K(6), EIF1AX(3), EIF2AK1(5), EIF2AK2(3), EIF2AK3(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G3(6), EIF5(2), EIF5B(5), ETF1(3), GSPT2(5), KIAA0664(7), PABPC1(2), PABPC3(8)	63025230	131	93	131	25	24	42	20	20	25	0	0.0749	1.000	1.000
306	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G2(2), EIF4G3(6), GHR(5), IRS1(4), MAPK1(1), MAPK14(2), MAPK3(1), MKNK1(2), PABPC1(2), PDK2(1), PDPK1(2), PRKCA(4), RPS6KB1(4)	32941568	59	45	58	13	9	25	5	8	12	0	0.447	1.000	1.000
307	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(7), ATM(23), ATR(13), CCND1(1), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), E2F1(5), GSK3B(2), HDAC1(5), SKP2(2), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1)	37959010	75	61	73	17	12	15	11	17	20	0	0.444	1.000	1.000
308	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), AKT1(2), BAD(1), BAX(3), BCL2L1(1), CSF2RB(4), IGF1R(7), IL3(1), IL3RA(3), KIT(8), KITLG(3), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	25357321	53	36	53	15	9	18	9	6	11	0	0.354	1.000	1.000
309	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(1), ACY3(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AMDHD1(4), AOC2(6), AOC3(3), ASPA(4), CARM1(5), CNDP1(7), DDC(4), FTCD(2), HAL(7), HARS(1), HEMK1(2), HNMT(2), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), PRPS2(1), UROC1(4), WBSCR22(2)	54699107	124	82	123	28	23	32	27	16	25	1	0.109	1.000	1.000
310	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(3), ALDOC(2), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), MDH1(1), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGK1(6), PGK2(1), PKLR(5), TNFAIP1(1), TPI1(2)	60080758	110	82	108	25	17	29	21	26	17	0	0.0761	1.000	1.000
311	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(4), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), OTC(3), PYCR1(1)	24762896	49	40	49	13	5	12	18	9	5	0	0.394	1.000	1.000
312	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM2(2), CHUK(8), EGR2(3), EGR3(4), GNAQ(1), MYC(1), NFATC1(5), NFATC2(4), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(2), VIP(1), VIPR2(4)	34296829	78	64	78	20	15	21	14	11	17	0	0.315	1.000	1.000
313	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2E1(2), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H3(2), GTF2I(4), GTF2IRD1(1), TAF1(16), TAF13(1), TAF1L(19), TAF2(7), TAF4(3), TAF4B(6), TAF5(4), TAF5L(5), TAF6(3), TAF6L(2), TAF7(1), TAF7L(6), TAF9(2), TBPL2(2)	50872537	95	67	94	18	19	29	13	19	15	0	0.0871	1.000	1.000
314	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(4), ACO2(5), CLYBL(3), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(6), PC(10), PCK1(5), PCK2(4), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1)	43162314	78	63	78	19	16	16	21	18	7	0	0.163	1.000	1.000
315	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(1), BCL2L1(1), CBL(4), CFLAR(1), CRKL(1), E2F1(5), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), IRS1(4), JAK1(11), JAK3(8), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	44288405	85	67	85	19	15	22	14	19	15	0	0.178	1.000	1.000
316	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(2), CAMK1(1), CAMK1G(5), ELK1(4), FPR1(3), GNB1(2), HRAS(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(1), NCF2(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PAK1(4), PIK3C2G(8), PLCB1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), RELA(3), SYT1(2)	50337950	119	88	118	27	17	36	22	26	18	0	0.133	1.000	1.000
317	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68827905	132	97	129	29	22	31	32	26	21	0	0.0624	1.000	1.000
318	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68827905	132	97	129	29	22	31	32	26	21	0	0.0624	1.000	1.000
319	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(7), ALOX12B(1), ALOX15(4), ALOX15B(5), ALOX5(3), CBR1(3), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2U1(1), CYP4A11(8), CYP4A22(2), CYP4F2(3), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3)	55405602	120	89	120	28	16	32	30	24	18	0	0.0704	1.000	1.000
320	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(10), GNA12(2), GNA13(1), GNAQ(1), GNB1(2), MYLK(11), PLCB1(13), PPP1R12B(4), PRKCA(4), ROCK1(8)	29874062	68	47	68	16	10	10	15	13	20	0	0.407	1.000	1.000
321	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(2), AKT2(5), AKT3(4), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GSK3A(5), GSK3B(2), IARS(8), INPP5D(4), PDK1(2), PPP1R13B(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SOS1(5), SOS2(6), TEC(6), YWHAB(2), YWHAG(1), YWHAZ(3)	46812632	97	72	96	22	18	27	13	17	22	0	0.202	1.000	1.000
322	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(3), DDX20(4), E2F1(5), E2F4(2), ETS1(3), ETS2(7), ETV3(4), FOS(1), HDAC2(2), HDAC5(6), HRAS(2), JUN(3), NCOR2(8), RBL1(6), SIN3A(10), SIN3B(7)	37458237	78	66	78	20	14	21	8	14	21	0	0.566	1.000	1.000
323	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), INSR(11), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SLC2A4(3), SOS1(5), SRF(1)	30065498	54	45	54	14	8	18	4	12	12	0	0.458	1.000	1.000
324	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(12), ACE2(4), AGT(3), AGTR1(4), AGTR2(2), ANPEP(8), CPA3(1), CTSA(3), CTSG(1), ENPEP(9), LNPEP(2), MAS1(2), MME(1), NLN(2), REN(1), THOP1(1)	30065638	56	37	56	15	8	15	7	16	10	0	0.452	1.000	1.000
325	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), ARHGAP5(12), BAD(1), BCAR1(6), BIRC2(3), BIRC3(4), BRAF(5), CAPN2(8), CAV1(4), CCND1(1), CCND2(3), CCND3(5), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(5), DOCK1(8), EGF(5), EGFR(5), ELK1(4), FARP2(10), FIGF(3), FLNA(20), FLNB(14), FLNC(21), FLT1(5), FN1(10), GSK3B(2), HGF(5), HRAS(2), IBSP(5), IGF1R(7), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), JUN(3), KDR(8), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), MAP2K1(5), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARVA(3), PARVG(3), PDGFB(2), PDGFRA(6), PDGFRB(7), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF1(5), RELN(26), RHOA(6), ROCK1(8), ROCK2(9), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SPP1(2), SRC(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TLN1(16), TLN2(14), TNC(10), TNN(10), TNR(11), TNXB(16), VAV1(6), VAV2(3), VAV3(7), VCL(6), VEGFA(1), VEGFC(2), VTN(3), VWF(11), ZYX(2)	511245771	1025	434	1013	312	201	247	189	194	189	5	0.839	1.000	1.000
326	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY7(11), ADCY8(6), ADCY9(14), ADORA2A(4), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), AGTR1(4), ATP2A1(11), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), ATP2B4(11), AVPR1B(5), BDKRB1(4), BDKRB2(4), BST1(3), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CCKAR(3), CCKBR(2), CD38(3), CHRM1(4), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), EDNRA(3), EDNRB(2), EGFR(5), ERBB3(19), ERBB4(14), F2R(4), GNA11(4), GNA14(1), GNAQ(1), GNAS(11), GRIN1(3), GRIN2A(16), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), GRPR(3), HRH1(4), HRH2(4), HTR2A(5), HTR2C(6), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), LHCGR(10), MYLK(11), MYLK2(5), NOS1(13), NOS3(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), PDE1A(5), PDE1B(5), PDE1C(5), PDGFRA(6), PDGFRB(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PLN(1), PPID(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTAFR(1), PTGER3(4), PTGFR(1), PTK2B(7), RYR1(29), RYR2(53), RYR3(43), SLC25A4(3), SLC25A5(2), SLC25A6(2), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(3), TACR1(2), TACR2(4), TACR3(2), TNNC2(2), TRPC1(9), VDAC1(1), VDAC2(3), VDAC3(1)	385301499	958	423	950	301	216	222	170	220	128	2	0.350	1.000	1.000
327	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(8), ACVR1C(2), AKT1(2), AKT2(5), AKT3(4), ARRB1(1), ARRB2(1), ATF2(4), ATF4(3), BDNF(2), BRAF(5), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CACNA2D1(7), CACNA2D2(7), CACNA2D3(9), CACNA2D4(5), CACNB1(3), CACNB2(3), CACNB3(4), CACNB4(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(3), CHUK(8), CRK(1), CRKL(1), DAXX(2), DUSP1(1), DUSP10(9), DUSP16(6), DUSP2(1), DUSP4(1), DUSP6(1), DUSP7(3), DUSP9(2), EGF(5), EGFR(5), ELK1(4), ELK4(1), FAS(1), FASLG(2), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FLNA(20), FLNB(14), FLNC(21), FOS(1), GNA12(2), HRAS(2), IKBKB(6), IL1A(1), IL1R1(1), IL1R2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAPT(4), MAX(2), MEF2C(4), MKNK1(2), MKNK2(4), MOS(3), MRAS(2), MYC(1), NF1(28), NFATC2(4), NFATC4(8), NFKB1(5), NFKB2(5), NLK(1), NR4A1(3), NRAS(2), NTRK1(8), NTRK2(5), PAK1(4), PAK2(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(2), PPM1B(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP5C(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTPN5(5), PTPN7(5), PTPRR(4), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF2(8), RASA1(2), RASA2(4), RASGRF1(12), RASGRF2(5), RASGRP2(6), RASGRP3(2), RASGRP4(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KA6(6), SOS1(5), SOS2(6), SRF(1), STK3(2), STK4(3), TAOK1(5), TAOK2(8), TAOK3(5), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF1A(4), TRAF2(1), TRAF6(4), ZAK(6)	404293685	882	416	870	261	180	209	144	173	173	3	0.461	1.000	1.000
328	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(3), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), APC(23), ARAF(6), ARHGEF1(10), ARHGEF12(11), ARHGEF4(7), ARHGEF6(6), ARHGEF7(8), ARPC1A(3), ARPC1B(2), ARPC2(5), ARPC5(1), ARPC5L(3), BAIAP2(2), BCAR1(6), BDKRB1(4), BDKRB2(4), BRAF(5), CD14(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CRK(1), CRKL(1), CYFIP1(5), CYFIP2(13), DIAPH1(5), DIAPH2(9), DIAPH3(6), DOCK1(8), EGF(5), EGFR(5), EZR(1), F2(2), F2R(4), FGD1(1), FGD3(4), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FN1(10), GIT1(3), GNA12(2), GNA13(1), GSN(2), HRAS(2), IQGAP1(7), IQGAP2(8), IQGAP3(9), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), LIMK1(8), LIMK2(4), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MOS(3), MRAS(2), MSN(4), MYH10(14), MYH14(13), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), NCKAP1(9), NCKAP1L(8), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDGFB(2), PDGFRA(6), PDGFRB(7), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PPP1R12B(4), PTK2(7), RAF1(4), RDX(3), RHOA(6), ROCK1(8), ROCK2(9), SCIN(5), SLC9A1(4), SOS1(5), SOS2(6), SSH1(7), SSH2(5), SSH3(4), TIAM1(7), TIAM2(11), VAV1(6), VAV2(3), VAV3(7), VCL(6), WAS(6), WASF1(6), WASF2(3), WASL(4)	390303008	824	363	810	276	167	209	129	167	149	3	0.987	1.000	1.000
329	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(5), ACTG1(8), COL11A1(8), COL11A2(5), COL17A1(9), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), DSC1(3), DSC2(12), DSC3(3), DSG1(4), DSG2(4), DSG3(8), DSG4(6), FN1(10), GJA1(4), GJA10(3), GJA4(1), GJA5(4), GJA8(2), GJA9(1), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJD2(2), GJD4(2), IBSP(5), ITGA6(4), ITGB4(8), KRT1(6), KRT10(1), KRT12(1), KRT13(2), KRT14(4), KRT15(1), KRT16(1), KRT17(2), KRT18(3), KRT19(7), KRT2(5), KRT20(2), KRT23(3), KRT24(2), KRT25(5), KRT27(1), KRT28(5), KRT3(4), KRT31(2), KRT32(4), KRT33A(1), KRT33B(1), KRT34(3), KRT35(2), KRT36(2), KRT37(1), KRT38(1), KRT39(1), KRT4(3), KRT40(1), KRT5(4), KRT6A(1), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(3), KRT73(5), KRT74(1), KRT75(4), KRT76(2), KRT78(3), KRT79(2), KRT8(2), KRT81(3), KRT82(4), KRT83(4), KRT84(3), KRT85(3), KRT86(4), KRT9(3), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), LMNA(4), LMNB1(2), LMNB2(3), NES(14), RELN(26), SPP1(2), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VIM(2), VTN(3), VWF(11)	347778600	667	347	660	224	134	158	149	121	103	2	0.963	1.000	1.000
330	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), ANXA6(5), ARRB1(1), ARRB2(1), ATP1A4(13), ATP1B1(3), ATP1B3(1), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1S(8), CACNB1(3), CACNB3(4), CALM2(2), CALR(1), CAMK1(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CASQ1(2), CASQ2(6), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), GJA1(4), GJA4(1), GJA5(4), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GNA11(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), ITPR1(15), ITPR2(18), ITPR3(14), KCNB1(7), KCNJ3(2), KCNJ5(1), MIB1(7), NME7(4), PEA15(1), PKIA(1), PKIG(2), PLCB3(2), PLN(1), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SLC8A3(4), USP5(7), YWHAB(2)	274079204	670	344	667	224	160	151	125	141	91	2	0.760	1.000	1.000
331	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(4), ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2B(4), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), C5AR1(3), CALCR(2), CALCRL(3), CCKAR(3), CCKBR(2), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GABBR1(3), GABBR2(4), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GABRB1(3), GABRB2(5), GABRB3(1), GABRD(1), GABRE(2), GABRG1(7), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(5), GABRR1(2), GALR1(1), GALR2(2), GALR3(1), GH2(3), GHR(5), GHRHR(5), GHSR(2), GIPR(1), GLP1R(2), GLP2R(4), GLRA2(2), GLRA3(2), GLRB(1), GPR156(4), GPR35(1), GPR50(4), GPR63(3), GPR83(5), GRIA1(9), GRIA2(4), GRIA3(16), GRIA4(8), GRID1(12), GRID2(11), GRIK1(11), GRIK2(12), GRIK3(6), GRIK4(3), GRIK5(5), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRIN3A(10), GRIN3B(3), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM6(2), GRM7(4), GRM8(5), GRPR(3), GZMA(2), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HRH4(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LEP(1), LEPR(7), LHCGR(10), MAS1(2), MC2R(2), MC3R(3), MC4R(2), MCHR1(1), MCHR2(3), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(3), NPFFR2(7), NPY1R(5), NPY2R(3), NR3C1(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(8), PPYR1(4), PRLHR(2), PRLR(4), PRSS3(3), PTAFR(1), PTGDR(2), PTGER2(2), PTGER3(4), PTGER4(1), PTGFR(1), PTH2R(2), RXFP1(4), RXFP2(3), SSTR2(1), SSTR3(2), SSTR4(1), SSTR5(1), TAAR1(3), TAAR2(4), TAAR5(4), TAAR6(2), TAAR8(1), TAAR9(2), TACR1(2), TACR2(4), TACR3(2), THRA(3), THRB(2), TRPV1(1), TSHR(7), VIPR1(2), VIPR2(4)	305056939	696	335	694	237	152	168	138	159	76	3	0.404	1.000	1.000
332	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), AMOTL1(6), ASH1L(19), CASK(9), CDK4(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CRB3(1), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTTN(2), EPB41(5), EPB41L1(7), EPB41L2(8), EPB41L3(11), EXOC3(6), EXOC4(9), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(2), HRAS(2), IGSF5(3), INADL(12), JAM2(1), LLGL1(5), LLGL2(3), MAGI1(17), MAGI2(9), MAGI3(7), MLLT4(20), MPDZ(13), MPP5(3), MRAS(2), MYH1(13), MYH10(14), MYH11(13), MYH13(11), MYH14(13), MYH15(16), MYH2(9), MYH3(5), MYH4(8), MYH6(11), MYH7(20), MYH7B(11), MYH8(15), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NRAS(2), OCLN(3), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(5), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), RAB13(3), RAB3B(1), RHOA(6), SPTAN1(13), SRC(1), SYMPK(8), TJAP1(3), TJP1(8), TJP2(6), TJP3(4), VAPA(2), YES1(2), ZAK(6)	276454964	636	324	626	182	126	162	99	127	118	4	0.743	1.000	1.000
333	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(7), CD36(5), CD44(4), CD47(2), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), DAG1(2), FN1(10), FNDC1(15), FNDC3A(5), GP5(3), GP6(4), HMMR(3), HSPG2(15), IBSP(5), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), RELN(26), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SPP1(2), SV2A(4), SV2B(4), SV2C(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VTN(3), VWF(11)	312799380	592	314	584	199	111	141	126	113	98	3	0.968	1.000	1.000
334	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(3), ACTA2(3), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(4), ATF3(2), ATF4(3), ATF5(1), ATP2A2(5), ATP2A3(2), CACNB3(4), CALCA(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CNN1(4), CNN2(1), CORIN(6), CREB3(1), CRHR1(3), DGKZ(1), ETS2(7), FOS(1), GABPA(1), GABPB2(2), GBA2(4), GJA1(4), GNAQ(1), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), GSTO1(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MIB1(7), MYLK2(5), NFKB1(5), NOS1(13), NOS3(3), OXTR(1), PDE4B(12), PDE4D(8), PKIA(1), PKIG(2), PLCB3(2), PLCD1(3), PLCG1(8), PLCG2(8), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RAMP3(1), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SP1(6), TNXB(16), USP5(7), YWHAB(2)	244696247	576	311	572	192	137	135	101	116	84	3	0.861	1.000	1.000
335	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(7), ABLIM1(4), ABLIM2(3), ABLIM3(6), ARHGEF12(11), CDK5(2), CFL1(1), CFL2(1), CXCR4(3), DCC(15), DPYSL2(2), DPYSL5(4), EFNA1(2), EFNA3(3), EFNA4(2), EFNA5(1), EFNB1(1), EFNB2(2), EFNB3(3), EPHA1(8), EPHA2(3), EPHA3(6), EPHA4(5), EPHA5(7), EPHA6(7), EPHA7(8), EPHA8(2), EPHB1(12), EPHB2(5), EPHB3(5), EPHB4(4), EPHB6(5), FES(3), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(2), HRAS(2), ITGB1(5), L1CAM(10), LIMK1(8), LIMK2(4), LRRC4C(4), MAPK1(1), MAPK3(1), MET(10), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NGEF(3), NRAS(2), NRP1(7), NTN1(3), NTN4(1), NTNG1(3), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLXNA1(12), PLXNA2(12), PLXNA3(9), PLXNB1(4), PLXNB2(9), PLXNB3(9), PLXNC1(6), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTK2(7), RASA1(2), RGS3(9), RHOA(6), RND1(2), ROBO1(13), ROBO2(11), ROBO3(6), ROCK1(8), ROCK2(9), SEMA3A(5), SEMA3C(7), SEMA3D(4), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(4), SEMA4B(2), SEMA4C(2), SEMA4D(8), SEMA4F(9), SEMA4G(6), SEMA5A(12), SEMA5B(6), SEMA6A(12), SEMA6C(5), SEMA6D(5), SEMA7A(2), SLIT1(2), SLIT2(11), SLIT3(5), SRGAP1(10), SRGAP2(12), SRGAP3(4), UNC5A(2), UNC5B(5), UNC5C(3), UNC5D(14)	271243810	590	300	585	179	113	149	122	109	97	0	0.606	1.000	1.000
336	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1B(8), ACVR2A(8), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1A(1), BMPR1B(6), BMPR2(8), CCL11(1), CCL13(4), CCL14(1), CCL15(1), CCL19(1), CCL2(1), CCL20(1), CCL21(1), CCL23(1), CCL26(1), CCL28(1), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CD40(2), CD40LG(1), CD70(1), CLCF1(1), CNTFR(2), CRLF2(1), CSF1(5), CSF1R(3), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(3), CXCL10(1), CXCL2(1), CXCL6(3), CXCR3(6), CXCR4(3), CXCR6(1), EDA(2), EDA2R(3), EDAR(4), EGF(5), EGFR(5), EPO(1), EPOR(4), FAS(1), FASLG(2), FLT1(5), FLT3(4), FLT3LG(1), FLT4(3), GDF5(2), GH2(3), GHR(5), HGF(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL15(3), IL17A(1), IL17B(2), IL17RA(2), IL17RB(3), IL18(2), IL18R1(4), IL18RAP(1), IL19(1), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(10), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL25(2), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL8(1), IL9R(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), KDR(8), KIT(8), KITLG(3), LEP(1), LEPR(7), LIF(2), LIFR(9), LTA(2), LTBR(1), MET(10), MPL(2), NGFR(1), OSM(1), OSMR(5), PDGFB(2), PDGFRA(6), PDGFRB(7), PF4(1), PLEKHO2(1), PPBP(1), PRLR(4), RELT(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(2), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(2), TNFSF13(1), TNFSF13B(1), TNFSF14(1), TNFSF15(2), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(8), TSLP(1), VEGFA(1), VEGFC(2), XCL1(2), XCR1(3)	251668965	515	283	510	132	77	131	102	108	95	2	0.0777	1.000	1.000
337	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(10), ACTN3(7), ACTN4(7), DMD(49), FAM48A(4), MYBPC1(4), MYBPC2(11), MYBPC3(3), MYH3(5), MYH6(11), MYH7(20), MYH8(15), MYL1(1), MYL9(1), MYOM1(7), NEB(42), TMOD1(1), TNNC2(2), TNNI3(4), TNNT1(2), TNNT3(3), TPM1(4), TPM2(2), TPM3(3), TPM4(1), TTN(278), VIM(2)	205997026	505	281	502	136	82	169	75	111	63	5	0.597	1.000	1.000
338	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	125	ACACA(13), ACACB(13), AKT1(2), AKT2(5), AKT3(4), ARAF(6), BAD(1), BRAF(5), CALM2(2), CALML6(1), CBL(4), CBLB(14), CBLC(7), CRK(1), CRKL(1), ELK1(4), EXOC7(6), FASN(14), FBP1(2), FLOT1(2), FLOT2(3), FOXO1(2), G6PC(2), G6PC2(3), GCK(3), GSK3B(2), GYS1(8), GYS2(1), HRAS(2), IKBKB(6), INPP5D(4), INSR(11), IRS1(4), IRS4(7), LIPE(5), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), MKNK2(4), NRAS(2), PCK1(5), PCK2(4), PDE3A(12), PDE3B(4), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PKLR(5), PPARGC1A(6), PPP1CB(1), PPP1R3A(13), PPP1R3B(2), PPP1R3C(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCI(1), PRKCZ(2), PRKX(5), PTPRF(11), PYGB(5), PYGL(3), PYGM(5), RAF1(4), RAPGEF1(5), RHEB(1), RHOQ(2), RPS6(4), RPS6KB1(4), RPS6KB2(5), SH2B2(1), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(1), SOCS4(2), SORBS1(7), SOS1(5), SOS2(6), SREBF1(4), TRIP10(4), TSC1(5), TSC2(8)	215738806	471	265	467	135	79	132	68	111	81	0	0.451	1.000	1.000
339	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	122	ALCAM(6), CADM1(3), CADM3(2), CD2(4), CD22(5), CD226(2), CD274(2), CD276(1), CD28(2), CD34(3), CD4(4), CD40(2), CD40LG(1), CD58(2), CD6(1), CD86(6), CD8A(3), CD8B(3), CD99(4), CDH15(2), CDH2(2), CDH3(1), CDH4(6), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CNTN1(11), CNTN2(7), CNTNAP1(11), CNTNAP2(11), CTLA4(1), ESAM(4), F11R(4), GLG1(6), HLA-A(3), HLA-B(6), HLA-C(9), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(5), HLA-G(1), ICAM1(2), ICAM2(1), ICAM3(3), ICOS(3), ICOSLG(6), ITGA4(6), ITGA6(4), ITGA8(10), ITGA9(7), ITGAL(5), ITGAM(6), ITGAV(7), ITGB1(5), ITGB2(8), ITGB7(5), ITGB8(4), JAM2(1), L1CAM(10), MADCAM1(1), MAG(3), MPZ(1), MPZL1(3), NCAM1(6), NCAM2(4), NEGR1(2), NEO1(6), NFASC(11), NLGN1(7), NLGN2(7), NLGN3(11), NRCAM(13), NRXN1(12), NRXN2(12), NRXN3(13), OCLN(3), PDCD1(2), PTPRC(8), PTPRF(11), PTPRM(8), PVR(3), PVRL1(3), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SELE(2), SELL(6), SELP(11), SELPLG(2), SIGLEC1(7), SPN(2), VCAM1(7), VCAN(22)	198380424	513	264	507	150	82	131	100	100	98	2	0.367	1.000	1.000
340	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(5), AKT3(4), BCL2L1(1), CBL(4), CBLB(14), CBLC(7), CCND1(1), CCND2(3), CCND3(5), CISH(2), CLCF1(1), CNTFR(2), CREBBP(15), CRLF2(1), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), EP300(13), EPO(1), EPOR(4), GH2(3), GHR(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL13RA2(5), IL15(3), IL19(1), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL9R(2), IRF9(4), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), LIF(2), LIFR(9), MPL(2), MYC(1), OSM(1), OSMR(5), PIAS1(3), PIAS2(7), PIAS3(3), PIAS4(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRLR(4), PTPN11(1), PTPN6(2), SOCS2(1), SOCS4(2), SOCS5(1), SOCS7(1), SOS1(5), SOS2(6), SPRED1(7), SPRED2(1), SPRY1(7), SPRY2(2), SPRY3(6), STAM(3), STAM2(4), STAT1(4), STAT2(5), STAT3(5), STAT4(8), STAT5A(6), STAT5B(5), STAT6(8), TPO(8), TSLP(1), TYK2(8)	201288342	470	261	466	102	66	114	95	102	90	3	0.0105	1.000	1.000
341	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADK(2), ADSL(3), ADSS(3), ADSSL1(1), AK1(1), AK2(1), AK5(4), AK7(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), FHIT(2), GART(3), GDA(2), GMPR2(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NME6(1), NME7(4), NPR1(5), NPR2(9), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), NUDT5(2), NUDT9(2), PAICS(3), PAPSS1(2), PAPSS2(2), PDE10A(8), PDE11A(5), PDE1A(5), PDE1C(5), PDE2A(4), PDE3B(4), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(5), PFAS(6), PKLR(5), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PPAT(5), PRIM1(1), PRPS2(1), PRUNE(4), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), XDH(9)	232866942	462	250	457	146	89	129	92	93	58	1	0.816	1.000	1.000
342	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(23), AXIN1(5), AXIN2(5), BTRC(4), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CCND1(1), CCND2(3), CCND3(5), CER1(2), CHD8(17), CREBBP(15), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK2A1(3), CSNK2A2(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(8), DAAM2(5), DKK2(1), DKK4(3), DVL1(2), DVL3(1), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LRP5(4), LRP6(7), MAP3K7(3), MAPK10(4), MAPK8(2), MAPK9(1), MYC(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKD1(1), NKD2(2), NLK(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PORCN(4), PPARD(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRICKLE1(2), PRICKLE2(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PSEN1(2), RHOA(6), ROCK1(8), ROCK2(9), RUVBL1(2), SENP2(1), SFRP1(3), SFRP2(2), SFRP4(2), SIAH1(3), SKP1(1), SMAD2(7), SMAD3(4), SMAD4(7), TBL1X(5), TCF7(4), TCF7L1(2), TCF7L2(5), VANGL1(2), VANGL2(8), WIF1(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	218110202	448	235	445	142	100	109	67	87	81	4	0.889	1.000	1.000
343	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ARHGAP5(12), BCAR1(6), CD99(4), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), CXCR4(3), CYBB(2), ESAM(4), EZR(1), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), ITK(7), JAM2(1), MAPK13(1), MAPK14(2), MLLT4(20), MMP2(4), MMP9(3), MSN(4), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NCF1(1), NCF2(7), NCF4(4), NOX1(5), NOX3(2), OCLN(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), PTK2B(7), PTPN11(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(5), RASSF5(5), RHOA(6), ROCK1(8), ROCK2(9), SIPA1(5), THY1(1), TXK(3), VAV1(6), VAV2(3), VAV3(7), VCAM1(7), VCL(6)	170150535	378	225	375	124	65	87	63	78	84	1	0.922	1.000	1.000
344	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ATF4(3), CACNA1C(17), CACNA1D(18), CACNA1F(17), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), EGFR(5), ELK1(4), GNA11(4), GNAQ(1), GNAS(11), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(4), MMP2(4), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLD1(7), PLD2(2), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(5), PRKX(5), PTK2B(7), RAF1(4), SOS1(5), SOS2(6), SRC(1)	178705299	379	224	375	124	82	97	57	84	59	0	0.828	1.000	1.000
345	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ACVR1B(8), ACVR1C(2), BAIAP2(2), CREBBP(15), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), EGFR(5), EP300(13), FARP2(10), FER(5), FGFR1(3), IGF1R(7), INSR(11), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MAPK3(1), MET(10), MLLT4(20), NLK(1), PARD3(8), PTPN6(2), PTPRB(12), PTPRF(11), PTPRJ(7), PTPRM(8), PVRL1(3), PVRL2(6), PVRL3(5), PVRL4(2), RHOA(6), SMAD2(7), SMAD3(4), SMAD4(7), SNAI1(2), SORBS1(7), SRC(1), SSX2IP(4), TCF7(4), TCF7L1(2), TCF7L2(5), TGFBR1(4), TGFBR2(4), TJP1(8), VCL(6), WAS(6), WASF1(6), WASF2(3), WASF3(5), WASL(4), YES1(2)	166595111	373	217	367	105	71	103	54	66	79	0	0.600	1.000	1.000
346	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), DRD1(1), DRD2(3), EGF(5), EGFR(5), GJA1(4), GJD2(2), GNA11(4), GNAI1(2), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(5), HTR2C(6), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(1), MAPK3(1), MAPK7(4), NPR1(5), NPR2(9), NRAS(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), PRKX(5), RAF1(4), SOS1(5), SOS2(6), SRC(1), TJP1(8), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5)	185873702	390	217	386	119	93	101	60	84	52	0	0.492	1.000	1.000
347	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2A(5), AMY2B(1), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENPP1(7), ENPP3(6), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), G6PC(2), G6PC2(3), GAA(2), GANC(4), GBA(2), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(22), MOV10L1(7), NUDT5(2), NUDT8(1), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SI(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5), TREH(2), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UXS1(3)	177904533	349	216	348	105	48	94	56	97	54	0	0.778	1.000	1.000
348	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(6), BRAF(5), CACNA1A(16), CRHR1(3), GNA11(4), GNA12(2), GNA13(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GNAZ(3), GRIA1(9), GRIA2(4), GRIA3(16), GRID2(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(7), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NOS1(13), NOS3(3), NPR1(5), NPR2(9), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), RAF1(4), RYR1(29)	157273017	367	215	365	95	81	98	68	70	49	1	0.0771	1.000	1.000
349	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(8), ACVRL1(1), AKT1(2), AURKB(3), BMPR1A(1), BMPR2(8), BUB1(3), CDKL1(4), CDKL2(2), CDS1(3), CDS2(3), CLK1(2), CLK2(6), CLK4(3), COL4A3BP(4), CSNK2A1(3), CSNK2A2(1), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), MAP3K10(3), MOS(3), NEK1(6), NEK3(3), OCRL(8), PAK4(3), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PIM2(4), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8), PLK3(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKG1(5), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KB1(4), STK11(2), TGFBR1(4), VRK1(2)	159309417	354	215	350	84	63	81	49	72	86	3	0.158	1.000	1.000
350	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(19), ASH2L(4), CARM1(5), CTCFL(5), DOT1L(10), EED(4), EHMT1(9), EHMT2(6), EZH1(3), EZH2(3), FBXO11(5), HCFC1(19), HSF4(1), JMJD6(2), KDM6A(17), MEN1(4), MLL(20), MLL2(25), MLL4(14), MLL5(11), NSD1(13), OGT(5), PAXIP1(6), PPP1CB(1), PRDM2(8), PRDM6(1), PRDM7(2), PRDM9(6), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(3), SATB1(10), SETD1A(4), SETD1B(9), SETD2(19), SETD7(5), SETD8(4), SETDB1(11), SETDB2(2), SETMAR(2), SMYD3(5), STK38(4), SUV39H1(2), SUV39H2(1), SUV420H1(8), SUV420H2(2), SUZ12(7), WHSC1(7), WHSC1L1(5)	159895189	353	212	347	74	48	91	59	66	88	1	0.160	1.000	1.000
351	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM2(2), CALML6(1), CDS1(3), CDS2(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5D(4), INPP5E(1), INPPL1(6), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), OCRL(8), PI4KA(10), PI4KB(6), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PRKCA(4), PRKCG(3), SYNJ1(4), SYNJ2(4)	172470870	365	211	361	100	64	90	52	81	77	1	0.421	1.000	1.000
352	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(15), ABCA12(12), ABCA13(37), ABCA2(7), ABCA3(10), ABCA4(12), ABCA5(8), ABCA6(9), ABCA7(10), ABCA8(16), ABCA9(13), ABCB1(9), ABCB10(9), ABCB11(13), ABCB4(10), ABCB5(5), ABCB6(8), ABCB7(7), ABCB8(8), ABCB9(1), ABCC1(12), ABCC10(7), ABCC11(7), ABCC12(10), ABCC2(7), ABCC3(9), ABCC4(10), ABCC5(10), ABCC6(7), ABCC8(12), ABCC9(13), ABCD1(5), ABCD2(4), ABCD3(4), ABCD4(3), ABCG1(5), ABCG2(1), ABCG4(7), ABCG5(2), ABCG8(2), CFTR(14), TAP1(2)	167928951	383	209	381	100	53	112	72	86	58	2	0.0460	1.000	1.000
353	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADK(2), ADSL(3), ADSS(3), AK1(1), AK2(1), AK5(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), ATP1B1(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), FHIT(2), GART(3), GDA(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NPR1(5), NPR2(9), NT5E(6), NUDT2(1), PAICS(3), PAPSS1(2), PAPSS2(2), PDE1A(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE6B(3), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(6), PKLR(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), PPAT(5), PRPS2(1), PRUNE(4), RRM1(4), RRM2(1)	181269997	355	209	350	116	69	101	65	70	49	1	0.872	1.000	1.000
354	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(7), ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), ATM(23), ATR(13), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDC14A(3), CDC14B(1), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), CREBBP(15), CUL1(2), E2F1(5), E2F3(3), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(24), PTTG1(1), PTTG2(1), RBL1(6), SFN(1), SKP1(1), SKP2(2), SMAD2(7), SMAD3(4), SMAD4(7), SMC1A(10), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), WEE1(4), YWHAB(2), YWHAG(1), YWHAZ(3)	189370820	355	205	351	78	49	105	51	70	79	1	0.173	1.000	1.000
355	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), AKAP1(3), AKAP10(1), AKAP11(13), AKAP12(10), AKAP3(6), AKAP4(8), AKAP6(16), AKAP7(1), AKAP8(4), AKAP9(24), ARHGEF1(10), CALM2(2), GNA11(4), GNA12(2), GNA13(1), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), HRAS(2), IL18BP(2), ITPR1(15), KCNJ3(2), NRAS(2), PALM2(3), PDE1A(5), PDE1B(5), PDE1C(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(5), PPP3CC(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKD3(6), RHOA(6), SLC9A1(4), USP5(7)	166583869	346	204	344	102	69	92	58	71	54	2	0.617	1.000	1.000
356	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	149	ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCBP2(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CCRL1(1), CCRL2(4), CHML(4), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(3), CXCR3(6), CXCR4(3), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR17(2), GPR173(1), GPR174(4), GPR3(2), GPR35(1), GPR37(5), GPR37L1(1), GPR50(4), GPR6(2), GPR63(3), GPR77(2), GPR83(5), GPR85(2), GPR87(2), GRPR(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LHCGR(10), MAS1(2), MC3R(3), MC4R(2), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(5), NPY2R(3), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1), RGR(1), RHO(2), RRH(1), SSTR2(1), SSTR3(2), SSTR4(1)	154900991	343	204	343	123	78	72	61	93	38	1	0.388	1.000	1.000
357	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(4), BCAR1(6), CAPN1(8), CAPN10(5), CAPN11(3), CAPN2(8), CAPN3(3), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(4), CRK(1), DOCK1(8), GIT2(1), ILK(3), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK4(6), MAPK6(6), MAPK7(4), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PDPK1(2), PIK3R2(4), PTK2(7), RAP1B(1), RAPGEF1(5), RHO(2), ROCK1(8), ROCK2(9), SDCCAG8(6), SEPP1(3), SHC1(2), SHC3(1), SORBS1(7), SOS1(5), SRC(1), TLN1(16), TNS1(7), VAV2(3), VAV3(7), VCL(6), ZYX(2)	192453535	359	201	358	118	66	100	57	74	60	2	0.880	1.000	1.000
358	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(6), BID(4), BRAF(5), CASP3(1), CD244(3), CD48(2), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(2), HLA-A(3), HLA-B(6), HLA-C(9), HLA-G(1), HRAS(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), ITGAL(5), ITGB2(8), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR3DL1(3), KIR3DL2(6), KLRC1(5), KLRC3(1), KLRD1(1), KLRK1(2), LAT(1), LCK(2), LCP2(2), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MICA(3), MICB(2), NCR1(3), NCR2(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NRAS(2), PAK1(4), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRF1(2), PRKCA(4), PRKCG(3), PTK2B(7), PTPN11(1), PTPN6(2), RAF1(4), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SYK(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	151515487	331	199	329	98	46	98	63	67	56	1	0.524	1.000	1.000
359	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), CREB3(1), CREB3L1(3), CREB3L2(4), CREB3L3(8), CREB3L4(2), CREBBP(15), CTNNB1(2), DCT(4), DVL1(2), DVL3(1), EDN1(5), EDNRB(2), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GSK3B(2), HRAS(2), KIT(8), KITLG(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MITF(3), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), TCF7(4), TCF7L1(2), TCF7L2(5), TYR(5), TYRP1(7), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	147770145	331	199	328	107	81	72	58	66	54	0	0.797	1.000	1.000
360	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(8), BDKRB1(4), BDKRB2(4), C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C3AR1(3), C4BPA(4), C4BPB(1), C5(5), C5AR1(3), C6(8), C7(8), C8A(2), C8B(3), C8G(1), C9(5), CD46(2), CD55(3), CD59(2), CFB(4), CFH(13), CFI(1), CPB2(4), CR1(14), CR2(5), F10(5), F12(2), F13A1(5), F13B(5), F2(2), F2R(4), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), KNG1(4), MASP1(8), MASP2(2), MBL2(2), PLAT(6), PLAU(4), PLAUR(2), PLG(7), PROC(3), PROS1(4), SERPINA1(4), SERPINA5(5), SERPINC1(6), SERPIND1(1), SERPINE1(5), SERPINF2(2), SERPING1(3), TFPI(4), THBD(2), VWF(11)	128318001	302	194	300	80	47	72	72	63	47	1	0.339	1.000	1.000
361	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(2), AKT2(5), AKT3(4), BCL10(3), CARD11(7), CBL(4), CBLB(14), CBLC(7), CD28(2), CD3E(3), CD3G(3), CD4(4), CD40LG(1), CD8A(3), CD8B(3), CDK4(1), CHUK(8), CTLA4(1), FOS(1), GRAP2(2), HRAS(2), ICOS(3), IFNG(2), IKBKB(6), IL4(1), ITK(7), JUN(3), LAT(1), LCK(2), LCP2(2), MALT1(3), MAP3K8(4), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDCD1(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCQ(9), PTPN6(2), PTPRC(8), RHOA(6), SOS1(5), SOS2(6), TEC(6), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	135559296	306	192	305	87	47	84	51	60	63	1	0.658	1.000	1.000
362	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(5), ADCY8(6), ARAF(6), ATF4(3), BRAF(5), CACNA1C(17), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CREBBP(15), EP300(13), GNAQ(1), GRIA1(9), GRIA2(4), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP1CB(1), PPP1R12A(8), PPP1R1A(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6)	144558938	335	191	332	101	71	87	53	70	54	0	0.481	1.000	1.000
363	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG6(2), ALG8(2), ALG9(2), B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT5(4), B4GALT7(1), C1GALT1(3), C1GALT1C1(3), CHPF(2), CHST1(4), CHST11(1), CHST2(5), CHST3(1), CHST4(1), CHST7(1), CHSY1(3), DAD1(1), DDOST(2), DPAGT1(4), EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), FUT11(3), FUT8(2), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GANAB(10), GCNT3(1), GCNT4(3), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), NDST1(4), NDST2(1), NDST3(5), OGT(5), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST6GAL1(3), ST6GALNAC1(6), STT3B(3), UST(2), WBSCR17(7), XYLT1(4), XYLT2(5)	151670375	320	190	318	100	63	77	54	74	48	4	0.740	1.000	1.000
364	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(7), ABL2(6), AKT1(2), AKT2(5), AKT3(4), ARAF(6), AREG(1), BAD(1), BRAF(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CBL(4), CBLB(14), CBLC(7), CDKN1A(1), CRK(1), CRKL(1), EGF(5), EGFR(5), ELK1(4), ERBB3(19), ERBB4(14), GAB1(2), GSK3B(2), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(2), NRG1(4), NRG2(4), NRG3(7), NRG4(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SRC(1), STAT5A(6), STAT5B(5), TGFA(1)	132827145	305	190	303	84	53	78	47	71	56	0	0.442	1.000	1.000
365	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(7), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGEF6(6), ARHGEF7(8), BCAR1(6), BRAF(5), CAV1(4), CDKN2A(1), CRK(1), CSE1L(6), DOCK1(8), EPHB2(5), GRB7(4), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGB3BP(3), MAP2K7(1), MAP3K11(5), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MRAS(2), MYLK(11), MYLK2(5), P4HB(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PKLR(5), PLCG1(8), PLCG2(8), PTK2(7), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(9), SHC1(2), SOS1(5), SOS2(6), SRC(1), TERF2IP(3), TLN1(16), TLN2(14), WAS(6), ZYX(2)	168229836	337	190	337	90	65	86	46	80	58	2	0.231	1.000	1.000
366	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(7), ATM(23), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDAN1(2), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DTX4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), HDAC8(3), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MPEG1(4), MPL(2), PLK1(2), PRKDC(24), PTPRA(6), PTTG1(1), PTTG2(1), RBL1(6), SKP2(2), SMAD4(7), TBC1D8(7), TFDP1(3), TGFB1(2), WEE1(4)	153913343	308	186	305	74	39	89	50	57	72	1	0.342	1.000	1.000
367	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1B(8), ACVR1C(2), ACVR2A(8), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BMPR1A(1), BMPR1B(6), BMPR2(8), CHRD(5), COMP(5), CREBBP(15), CUL1(2), DCN(2), E2F4(2), EP300(13), FST(3), GDF5(2), GDF6(1), ID1(1), ID2(2), ID3(1), IFNG(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), LEFTY2(1), LTBP1(9), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), NOG(1), PITX2(5), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(6), RHOA(6), ROCK1(8), ROCK2(9), RPS6KB1(4), RPS6KB2(5), SKP1(1), SMAD1(1), SMAD2(7), SMAD3(4), SMAD4(7), SMAD5(2), SMAD7(1), SMAD9(4), SMURF1(3), SMURF2(5), SP1(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), THBS1(8), THBS2(2), THBS3(5), THBS4(4), ZFYVE16(5), ZFYVE9(4)	137911792	270	177	265	70	52	65	28	66	59	0	0.463	1.000	1.000
368	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(4), BRAF(5), CHUK(8), CREB1(2), DAXX(2), ELK1(4), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAP4K5(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MKNK2(4), MYC(1), NFKB1(5), NFKBIA(3), PAK1(4), PAK2(2), RAF1(4), RELA(3), RIPK1(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SP1(6), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	131576012	278	175	274	54	54	79	32	50	63	0	0.00642	1.000	1.000
369	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(5), BAD(1), CABIN1(8), CALM2(2), CAMK2B(3), CAMK4(5), CD3E(3), CD3G(3), CD69(2), CDKN1A(1), CNR1(1), CREBBP(15), CSNK2A1(3), CTLA4(1), EGR2(3), EGR3(4), EP300(13), FCER1A(4), FCGR3A(4), FOS(1), GATA4(2), GSK3A(5), GSK3B(2), HRAS(2), ICOS(3), IFNA1(1), IFNG(2), IL2RA(2), IL3(1), IL4(1), IL6(2), IL8(1), ITK(7), KPNA5(5), MAP2K7(1), MAPK14(2), MAPK8(2), MAPK9(1), MEF2A(6), MEF2D(3), MYF5(4), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB2(5), NFKBIB(2), NFKBIE(2), NUP214(12), OPRD1(3), P2RX7(3), PAK1(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPRC(8), RELA(3), RPL13A(4), SFN(1), SLA(1), SP1(6), SP3(7), TGFB1(2), TRAF2(1), TRPV6(5), VAV1(6), VAV2(3), VAV3(7), XPO5(8)	126119295	269	168	268	66	33	66	46	61	63	0	0.229	1.000	1.000
370	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(8), CD14(1), CD19(6), CD1A(2), CD1B(5), CD1C(4), CD1D(3), CD1E(7), CD2(4), CD22(5), CD33(2), CD34(3), CD36(5), CD37(3), CD38(3), CD3E(3), CD3G(3), CD4(4), CD44(4), CD5(3), CD55(3), CD59(2), CD7(1), CD8A(3), CD8B(3), CD9(2), CR1(14), CR2(5), CSF1(5), CSF1R(3), CSF2RA(3), CSF3(2), CSF3R(6), DNTT(6), EPO(1), EPOR(4), FCER2(1), FCGR1A(5), FLT3(4), FLT3LG(1), GP5(3), GYPA(1), HLA-DRB1(10), IL11(1), IL11RA(5), IL1A(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL7(1), IL7R(4), IL9R(2), ITGA1(6), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(4), KIT(8), KITLG(3), MME(1), MS4A1(1), TFRC(2), THPO(3), TPO(8)	116462184	273	168	273	78	40	68	56	62	46	1	0.511	1.000	1.000
371	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(2), AKT2(5), AKT3(4), CD14(1), CD40(2), CD86(6), CHUK(8), CXCL10(1), FOS(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(6), IKBKE(6), IL12B(2), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(6), IRF5(2), IRF7(1), JUN(3), LBP(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(4), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), RELA(3), RIPK1(5), SPP1(2), STAT1(4), TBK1(1), TICAM1(2), TIRAP(1), TLR1(3), TLR2(3), TLR3(7), TLR4(15), TLR5(4), TLR7(9), TLR8(13), TLR9(2), TRAF3(3), TRAF6(4)	116791160	257	163	257	57	32	73	42	56	52	2	0.0473	1.000	1.000
372	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(3), AKT1(2), AKT2(5), AKT3(4), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CAPN1(8), CAPN2(8), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), CSF2RB(4), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL3(1), IL3RA(3), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), NTRK1(8), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(4), TRAF2(1)	110416201	246	160	243	47	35	72	44	41	54	0	0.00997	1.000	1.000
373	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(13), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADIPOR1(1), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(5), AKT3(4), CAMKK1(3), CAMKK2(4), CD36(5), CHUK(8), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), G6PC(2), G6PC2(3), IKBKB(6), IRS1(4), IRS4(7), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), MAPK10(4), MAPK8(2), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NPY(1), PCK1(5), PCK2(4), PPARA(4), PPARGC1A(6), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(9), PTPN11(1), RELA(3), RXRA(2), RXRG(2), SLC2A4(3), STAT3(5), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(8)	113465716	246	154	243	67	48	55	41	46	54	2	0.394	1.000	1.000
374	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(1), CDC40(3), CLK2(6), CLK3(4), CLK4(3), COL2A1(4), CPSF1(10), CPSF2(3), CPSF3(6), CPSF4(4), CSTF1(1), CSTF2(2), CSTF2T(4), CSTF3(8), DDX1(3), DDX20(4), DHX15(9), DHX16(2), DHX38(4), DHX8(7), DHX9(8), DICER1(8), DNAJC8(1), FUS(3), GIPC1(1), METTL3(2), NCBP1(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(5), POLR2A(6), PPM1G(2), PRPF18(2), PRPF3(5), PRPF4(3), PRPF4B(9), PRPF8(12), PSKH1(3), PTBP1(6), PTBP2(3), RBM17(1), RBM5(5), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B2(5), SF3B4(3), SF3B5(1), SNRPA(1), SNRPB(2), SNRPD2(2), SNRPG(2), SNRPN(3), SPOP(5), SRPK1(3), SRPK2(5), SRRM1(6), SUPT5H(12), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4)	145735066	253	150	253	57	31	71	46	59	44	2	0.262	1.000	1.000
375	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(1), ALG6(2), CCKBR(2), CCR2(7), CCR3(2), CCR5(1), CELSR1(14), CELSR2(14), CELSR3(12), CHRM2(6), CHRM3(3), CIDEB(2), CXCR3(6), EDNRA(3), EMR2(9), EMR3(7), F2R(4), FSHR(9), GHRHR(5), GPR116(7), GPR132(1), GPR133(6), GPR135(1), GPR143(4), GPR17(2), GPR55(3), GPR56(3), GPR61(2), GPR77(2), GPR84(7), GRM1(9), GRPR(3), HRH4(2), LGR6(5), LPHN2(11), LPHN3(8), P2RY13(4), PTGFR(1), SMO(5), SSTR2(1), TAAR5(4), TSHR(7), VN1R1(1)	87242127	208	145	208	64	29	53	33	56	37	0	0.311	1.000	1.000
376	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(2), AKT2(5), AKT3(4), BCL10(3), BLNK(1), BTK(7), CARD11(7), CD19(6), CD22(5), CD72(5), CD79B(2), CHUK(8), CR2(5), FOS(1), GSK3B(2), HRAS(2), IFITM1(1), IKBKB(6), INPP5D(4), JUN(3), LILRB3(6), LYN(6), MALT1(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPN6(2), RASGRP3(2), SYK(4), VAV1(6), VAV2(3), VAV3(7)	98035587	219	145	218	67	39	57	35	46	42	0	0.673	1.000	1.000
377	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(1), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), TK1(1), TK2(1), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3), UPRT(3)	115776082	217	143	215	66	36	62	38	49	31	1	0.724	1.000	1.000
378	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5E(1), INPPL1(6), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(3), OCRL(8), PI4KA(10), PI4KB(6), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), SYNJ1(4), SYNJ2(4)	100084930	223	143	222	51	41	56	36	40	49	1	0.0898	1.000	1.000
379	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(5), AKT3(4), BTK(7), FCER1A(4), GAB2(5), HRAS(2), IL3(1), IL4(1), INPP5D(4), LAT(1), LCP2(2), LYN(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), NRAS(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PRKCA(4), PRKCD(5), PRKCE(8), RAF1(4), SOS1(5), SOS2(6), SYK(4), VAV1(6), VAV2(3), VAV3(7)	94166052	193	137	193	47	33	47	32	43	38	0	0.182	1.000	1.000
380	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), CD22(5), CR2(5), DAG1(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPP5D(4), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP4K1(10), MAPK1(1), MAPK3(1), NFATC1(5), NFATC2(4), NR0B2(2), PDK1(2), PIK3CD(6), PLCG2(8), PPP1R13B(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PTPRC(8), RAF1(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	97742845	197	133	196	52	37	50	28	55	27	0	0.200	1.000	1.000
381	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(11), ATM(23), ATR(13), BAI1(10), BAX(3), BBC3(2), BID(4), CASP3(1), CASP9(3), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DDB2(2), EI24(3), FAS(1), GTSE1(10), IGFBP3(1), MDM2(3), MDM4(3), PERP(1), PMAIP1(2), PPM1D(2), RCHY1(2), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINE1(5), SESN2(2), SESN3(1), SFN(1), SIAH1(3), STEAP3(2), THBS1(8), TNFRSF10B(1), TP53I3(3), TP73(2), TSC2(8)	87114472	192	132	189	38	29	55	26	32	49	1	0.0967	1.000	1.000
382	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(2), ADCY8(6), CACNA1A(16), CACNA1B(14), GNAS(11), GNAT3(1), GNB1(2), GNB3(3), GRM4(3), ITPR3(14), KCNB1(7), PDE1A(5), PLCB2(7), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), SCNN1A(3), SCNN1B(2), SCNN1G(1), TAS1R1(3), TAS1R2(4), TAS1R3(1), TAS2R1(4), TAS2R10(4), TAS2R13(2), TAS2R14(2), TAS2R16(5), TAS2R3(3), TAS2R38(2), TAS2R39(1), TAS2R40(2), TAS2R41(2), TAS2R42(2), TAS2R43(4), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R8(2), TAS2R9(2), TRPM5(10)	80411911	176	130	174	46	37	44	32	34	29	0	0.120	1.000	1.000
383	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCL2L1(1), CDK2(2), CDKN2A(1), CREB1(2), CREB3(1), CREB5(4), EBP(1), ERBB4(14), F2RL2(2), GAB1(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), MET(10), MYC(1), NOLC1(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), PPP1R13B(4), PREX1(10), PTK2(7), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SLC2A4(3), SOS1(5), SOS2(6), TSC1(5), TSC2(8), YWHAB(2), YWHAG(1), YWHAZ(3)	100468418	200	130	199	58	34	55	32	38	40	1	0.641	1.000	1.000
384	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), AKT2(5), AKT3(4), BAD(1), CASP9(3), HRAS(2), KDR(8), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NOS3(3), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCA(4), PRKCG(3), PTGS2(5), PTK2(7), RAF1(4), SH2D2A(4), SHC2(3), SPHK1(1), SPHK2(3), SRC(1), VEGFA(1)	93162412	190	128	190	66	34	50	38	39	29	0	0.868	1.000	1.000
385	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	69	B2M(3), CALR(1), CANX(3), CD4(4), CD74(2), CD8A(3), CD8B(3), CIITA(5), CREB1(2), CTSB(2), CTSL1(4), CTSS(3), HLA-A(3), HLA-B(6), HLA-C(9), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(5), HLA-G(1), HSP90AA1(3), HSP90AB1(5), HSPA5(5), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR2DS4(4), KIR3DL1(3), KIR3DL2(6), KIR3DL3(3), KLRC1(5), KLRC3(1), KLRD1(1), LGMN(2), LTA(2), NFYB(1), NFYC(4), PSME1(1), RFX5(3), RFXANK(3), RFXAP(1), TAP1(2)	56447905	174	128	173	48	18	49	50	29	27	1	0.422	1.000	1.000
386	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(28), B3GALT4(2), CDR1(2), DGKI(7), IL6ST(9), RPL10(2), RPL12(1), RPL13A(4), RPL15(1), RPL18(1), RPL18A(4), RPL19(2), RPL23(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36(1), RPL3L(3), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPL8(2), RPL9(1), RPLP0(2), RPLP2(1), RPS10(1), RPS12(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS4X(2), RPS5(6), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), RPS8(1), RPS9(2), SLC36A2(5), TBC1D10C(4), TSPAN9(3), UBA52(2), UBC(13)	75106080	174	126	172	47	38	49	32	29	25	1	0.480	1.000	1.000
387	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AGK(4), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AKR1A1(1), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DAK(4), DGAT1(2), DGAT2(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), GK(6), GK2(4), GLA(5), GLB1(4), GPAM(6), LCT(17), LIPA(4), LIPC(2), LIPF(1), LIPG(3), LPL(1), MGLL(2), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(3), PPAP2A(2), PPAP2C(1)	83683793	177	125	175	43	35	35	40	33	33	1	0.0923	1.000	1.000
388	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(23), AXIN1(5), CCND1(1), CCND2(3), CCND3(5), CSNK1E(4), CTNNB1(2), DVL1(2), DVL3(1), FBXW2(4), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LDLR(6), MAPK10(4), MAPK9(1), MYC(1), PAFAH1B1(3), PLAU(4), PPP2R5C(6), PPP2R5E(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), RHOA(6), SFRP4(2), TCF7(4), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1)	80062020	186	125	185	52	45	39	29	35	34	4	0.507	1.000	1.000
389	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	60	ATM(23), CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK7(3), CDKN1A(1), CDKN2A(1), CREB3(1), CREB3L1(3), CREB3L3(8), CREB3L4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), GBA2(4), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MNAT1(2), MYC(1), MYT1(10), NACA(8), POLA2(6), POLE(10), POLE2(2), PRIM1(1), RBL1(6), RPA1(1), RPA2(2), RPA3(2), TFDP1(3), TFDP2(4), TNXB(16), WEE1(4)	100629514	193	123	190	46	31	58	26	41	36	1	0.281	1.000	1.000
390	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2A(5), AMY2B(1), ENPP1(7), ENPP3(6), G6PC(2), GAA(2), GANAB(10), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(22), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RNPC3(2), SI(18), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UXS1(3)	82974920	180	123	179	69	28	40	33	55	24	0	0.982	1.000	1.000
391	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(1), ACADL(1), ACOX1(4), ACOX2(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ANGPTL4(1), APOA1(3), APOA5(3), AQP7(1), CD36(5), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP27A1(1), CYP4A11(8), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(4), FABP1(2), FABP2(1), FABP3(1), FABP6(1), FABP7(1), FADS2(7), GK(6), GK2(4), HMGCS2(3), ILK(3), LPL(1), MMP1(2), NR1H3(2), OLR1(2), PCK1(5), PCK2(4), PDPK1(2), PLTP(3), PPARA(4), PPARD(2), PPARG(5), RXRA(2), RXRG(2), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(6), SLC27A5(4), SORBS1(7), UBC(13)	91423213	193	122	192	64	32	49	38	46	27	1	0.793	1.000	1.000
392	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(2), CREBBP(15), CTBP1(1), CTBP2(1), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(3), DTX3(3), DTX3L(4), DTX4(2), DVL1(2), DVL3(1), EP300(13), HDAC1(5), HDAC2(2), HES1(1), JAG1(9), JAG2(1), MAML1(3), MAML2(4), MAML3(7), NCOR2(8), NCSTN(7), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(4), PSENEN(2), PTCRA(3), RBPJL(5), RFNG(2), SNW1(2)	90067017	185	122	184	69	41	35	39	31	39	0	0.975	1.000	1.000
393	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGAP1(4), ARHGAP4(6), ARHGEF11(6), BTK(7), CFL1(1), CFL2(1), GDI1(3), GDI2(2), INPPL1(6), ITPR1(15), ITPR2(18), ITPR3(14), LIMK1(8), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDK1(2), PIK3CD(6), PIK3CG(5), PITX2(5), PPP1R13B(4), RACGAP1(3), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), SAG(3), WASF1(6), WASL(4)	93512708	205	122	203	63	37	51	35	44	37	1	0.718	1.000	1.000
394	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(5), CPEB1(7), EGFR(5), ERBB4(14), ETS1(3), ETS2(7), ETV6(4), ETV7(3), FMN2(17), MAP2K1(5), MAPK1(1), MAPK3(1), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), PIWIL1(17), PIWIL2(5), PIWIL3(7), PIWIL4(4), RAF1(4), SOS1(5), SOS2(6), SPIRE1(2)	64998107	172	121	169	46	18	44	37	41	31	1	0.552	1.000	1.000
395	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(8), EGFR(5), F11R(4), GIT1(3), IGSF5(3), IKBKB(6), IL8(1), JAM2(1), JUN(3), LYN(6), MAPK10(4), MAPK13(1), MAPK14(2), MAPK8(2), MAPK9(1), MET(10), NFKB1(5), NFKB2(5), NFKBIA(3), NOD1(6), PAK1(4), PLCG1(8), PLCG2(8), PTPN11(1), PTPRZ1(11), RELA(3), SRC(1), TCIRG1(4), TJP1(8)	100356991	179	121	177	53	33	53	28	23	42	0	0.643	1.000	1.000
396	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CX3CR1(3), CXCR3(6), CXCR4(3), CXCR6(1), EDNRA(3), EDNRB(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR77(2), GRPR(3), LHCGR(10), MC2R(2), MC3R(3), MC4R(2), NMBR(3), NPY1R(5), NPY2R(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), PPYR1(4), SSTR2(1), SSTR3(2), SSTR4(1), TACR1(2), TACR2(4), TACR3(2), TSHR(7)	71625023	173	120	173	50	31	45	29	48	19	1	0.107	1.000	1.000
397	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ABP1(1), ACAT1(3), AFMID(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CARM1(5), CAT(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADH(2), HADHA(3), HEMK1(2), HSD17B10(1), HSD17B4(8), INMT(4), KMO(8), KYNU(3), LCMT1(1), LCMT2(10), LNX1(6), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), NFX1(4), OGDH(7), OGDHL(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(2), TPH1(3), TPH2(4), WARS2(2), WBSCR22(2)	86417772	176	119	175	58	24	53	42	30	25	2	0.809	1.000	1.000
398	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CHPT1(4), CRLS1(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), ESCO1(4), ESCO2(1), ETNK1(4), ETNK2(4), GNPAT(5), GPAM(6), GPD1(6), GPD1L(1), GPD2(3), LCAT(1), PCYT1A(2), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PNPLA3(3), PPAP2A(2), PPAP2C(1), PTDSS1(5), PTDSS2(3), SH3GLB1(2)	92670771	165	118	164	45	27	38	29	44	26	1	0.327	1.000	1.000
399	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(5), AKT3(4), BCR(3), BTK(7), CD19(6), CDKN2A(1), DAPP1(2), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PITX2(5), PLCG2(8), PPP1R13B(4), PREX1(10), PTPRC(8), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SAG(3), SYK(4), TEC(6), VAV1(6)	74625418	175	118	173	37	37	40	26	43	29	0	0.0281	1.000	1.000
400	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BTRC(4), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK1G1(1), CSNK1G2(2), CSNK1G3(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(2), HHIP(1), IHH(2), LRP2(33), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), PTCH1(11), PTCH2(2), SHH(1), SMO(5), STK36(1), SUFU(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1), ZIC2(1)	80608756	163	117	162	54	48	38	26	32	19	0	0.729	1.000	1.000
401	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(5), AKT3(4), ASAH1(1), BRAF(5), DAG1(2), DRD2(3), EGFR(5), EPHB2(5), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(8), PITX2(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), RAF1(4), RGS20(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT3(5), TERF2IP(3)	83303492	175	117	173	41	30	46	19	49	31	0	0.110	1.000	1.000
402	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(4), AASS(5), ACAT1(3), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), NSD1(13), OGDH(7), OGDHL(6), PIPOX(2), PLOD1(2), PLOD2(2), PLOD3(9), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SETD1A(4), SETD7(5), SETDB1(11), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(2), SUV39H2(1), TMLHE(1)	79094475	162	116	159	46	25	42	40	32	23	0	0.504	1.000	1.000
403	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(1), ALPP(3), ALPPL2(2), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), FPGS(4), GCH1(1), IFIH1(4), MOV10L1(7), NUDT5(2), NUDT8(1), QDPR(1), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5)	88654516	160	115	160	35	25	46	29	33	27	0	0.112	1.000	1.000
404	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), CARM1(5), COMT(1), DBH(6), DCT(4), DDC(4), ECH1(1), ESCO1(4), ESCO2(1), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HEMK1(2), HGD(4), HPD(4), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PNMT(1), PNPLA3(3), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(3), TH(2), TPO(8), TYR(5), TYRP1(7), WBSCR22(2)	82655347	170	113	167	40	31	40	41	26	30	2	0.188	1.000	1.000
405	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	53	ALG2(2), BAK1(3), BAX(3), BFAR(3), BTK(7), CAD(17), CASP10(2), CASP3(1), CD7(1), CSNK1A1(4), DAXX(2), DEDD(1), DEDD2(1), DFFA(4), DIABLO(1), EGFR(5), EPHB2(5), FAF1(7), IL1A(1), IL8(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MET(10), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR0B2(2), PTPN13(16), RALBP1(3), RIPK1(5), ROCK1(8), SMPD1(2), TNFRSF6B(1), TPX2(2), TRAF2(1), TUFM(3)	89218438	180	113	177	43	34	53	26	32	34	1	0.231	1.000	1.000
406	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(5), AKT3(4), BRAF(5), CAB39(1), DDIT4(1), EIF4B(2), FIGF(3), HIF1A(4), MAPK1(1), MAPK3(1), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRKAA1(3), PRKAA2(2), RHEB(1), RICTOR(7), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), STK11(2), TSC1(5), TSC2(8), ULK1(5), ULK2(6), ULK3(5), VEGFA(1), VEGFC(2)	68263902	153	111	152	34	25	48	22	26	32	0	0.185	1.000	1.000
407	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), F10(5), F12(2), F2(2), F2R(4), F5(26), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), PROC(3), PROS1(4), SERPINC1(6), SERPING1(3)	64590142	151	110	151	38	22	35	41	29	24	0	0.309	1.000	1.000
408	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3)	70331406	159	108	155	55	29	48	24	32	26	0	0.920	1.000	1.000
409	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3)	70331406	159	108	155	55	29	48	24	32	26	0	0.920	1.000	1.000
410	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(2), BDKRB2(4), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(4), FLT1(5), FLT4(3), KDR(8), NOS3(3), PDE2A(4), PDE3A(12), PDE3B(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKG1(5), PRKG2(8), RYR2(53), SYT1(2)	58864376	145	108	144	64	20	42	30	31	20	2	0.995	1.000	1.000
411	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(4), APOA1(3), CD36(5), CITED2(2), CPT1B(4), CREBBP(15), DUSP1(1), DUT(1), EHHADH(4), EP300(13), FABP1(2), HSD17B4(8), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(2), MYC(1), NCOA1(5), NCOR2(8), NFKBIA(3), NR0B2(2), NR1H3(2), NR2F1(1), NRIP1(10), PPARA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PTGS2(5), RELA(3), RXRA(2), SP1(6), SRA1(1), STAT5A(6), STAT5B(5)	72881706	153	108	153	37	27	36	23	28	38	1	0.290	1.000	1.000
412	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(2), APC(23), AR(6), ASAH1(1), BRAF(5), CCL13(4), CCL15(1), DAG1(2), EGFR(5), GNA11(4), GNAI1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), MAPK10(4), MAPK14(2), PHKA2(13), PIK3CD(6), PITX2(5), PTX3(1), RAF1(4), SRC(1)	70594519	153	108	151	39	25	41	17	46	23	1	0.254	1.000	1.000
413	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(4), CD28(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(5), GRAP2(2), ITK(7), ITPKA(1), ITPKB(8), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLCG1(8), PTPRC(8), RAF1(4), RASGRP2(6), RASGRP3(2), RASGRP4(5), SOS1(5), SOS2(6), VAV1(6), ZAP70(3)	75647715	142	108	142	55	26	38	19	32	27	0	0.983	1.000	1.000
414	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(8), ATP4B(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), ATP5L(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(7), COX15(3), COX17(2), COX4I2(2), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), COX7B2(3), NDUFA1(2), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA4(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA9(3), NDUFB1(2), NDUFB10(1), NDUFB3(1), NDUFB5(4), NDUFB6(2), NDUFB8(1), NDUFB9(3), NDUFS1(1), NDUFS2(7), NDUFS3(1), NDUFS5(1), NDUFS6(1), NDUFS7(2), NDUFS8(1), NDUFV1(5), NDUFV2(1), NDUFV3(5), PPA1(4), PPA2(2), SDHB(2), SDHD(1), TCIRG1(4), UQCRB(1), UQCRC1(1), UQCRC2(4), UQCRFS1(1)	80638428	170	107	170	41	29	48	28	36	29	0	0.118	1.000	1.000
415	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1C1(5), AKR1C2(3), AKR1C3(1), AKR1C4(3), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2F1(5), CYP2S1(6), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHDH(1), EPHX1(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), MGST3(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3)	81645445	169	107	167	55	18	45	36	47	23	0	0.716	1.000	1.000
416	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(3), AKT1(2), CALM2(2), CALR(1), CAMK1(1), CAMK1G(5), CAMK4(5), CREBBP(15), CSNK1A1(4), EDN1(5), F2(2), GATA4(2), GSK3B(2), HAND2(4), HRAS(2), LIF(2), MAP2K1(5), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(9), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKX2-5(1), NPPA(1), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAF1(4), RPS6KB1(4), SYT1(2)	65396071	146	106	146	43	22	39	30	34	20	1	0.530	1.000	1.000
417	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ITPA(1), NT5E(6), NUDT2(1), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(1), TXNRD1(6), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3)	80973631	142	106	140	48	23	42	21	29	26	1	0.894	1.000	1.000
418	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(14), CARM1(5), CCND1(1), CREBBP(15), EP300(13), ERCC3(5), ESR1(7), GRIP1(7), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), MEF2C(4), NCOR2(8), NRIP1(10), PELP1(7), POLR2A(6), SRA1(1), TBP(2)	66529685	146	105	145	41	20	34	26	30	36	0	0.694	1.000	1.000
419	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(2), ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), G6PC2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGAM4(2), PGK1(6), PGK2(1), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	81976631	146	104	143	33	21	37	35	31	22	0	0.0574	1.000	1.000
420	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(8), ACTG2(4), ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), CFL1(1), CFL2(1), FLNA(20), FLNC(21), FSCN1(1), FSCN3(1), GDI1(3), GDI2(2), LIMK1(8), MYH2(9), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), WASF1(6), WASL(4)	65416441	156	104	155	49	33	31	29	33	29	1	0.766	1.000	1.000
421	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(3), AKR1D1(1), ARSE(4), CARM1(5), CYP11B1(5), CYP11B2(4), HEMK1(2), HSD11B1(3), HSD11B2(2), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B7(1), HSD3B1(3), HSD3B2(4), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SRD5A1(4), STS(1), SULT1E1(4), SULT2B1(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), WBSCR22(2)	69242281	146	103	145	47	14	45	33	30	23	1	0.727	1.000	1.000
422	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(8), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PI3(1), PIK3CD(6), PLCG2(8), PPP1R13B(4), RAF1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	66822342	133	101	133	33	26	35	19	31	22	0	0.216	1.000	1.000
423	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F12(2), F13B(5), F2(2), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), LPA(16), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5), SERPINF2(2), VWF(11)	49965990	130	100	128	36	19	25	37	27	22	0	0.479	1.000	1.000
424	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1A1(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DGAT1(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), GK(6), GLA(5), GLB1(4), LCT(17), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(2), PPAP2C(1)	68462312	138	100	136	39	30	25	30	24	29	0	0.369	1.000	1.000
425	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CLC(1), CPT1B(4), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), ETNK1(4), GNPAT(5), GPD1(6), GPD2(3), LCAT(1), LGALS13(3), PAFAH1B1(3), PCYT1A(2), PCYT1B(6), PEMT(1), PISD(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(7), PLCG1(8), PLCG2(8), PPAP2A(2), PPAP2C(1)	70080437	139	99	138	39	24	29	21	35	29	1	0.392	1.000	1.000
426	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), BCR(3), CAPN1(8), CAV1(4), CRKL(1), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(7), RAF1(4), RAP1A(2), ROCK1(8), SHC1(2), SOS1(5), SRC(1), TLN1(16), VCL(6), ZYX(2)	66653621	132	99	132	46	28	34	17	25	26	2	0.900	1.000	1.000
427	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	CHUK(8), DAXX(2), EGF(5), EGFR(5), ETS1(3), ETS2(7), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(5), NFKBIA(3), PPP2CA(3), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), RAF1(4), RELA(3), RIPK1(5), SP1(6), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	63782664	139	97	136	36	30	33	17	30	28	1	0.390	1.000	1.000
428	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(6), ARHGAP5(12), ARHGAP6(5), ARHGEF1(10), ARHGEF11(6), ARHGEF5(10), ARPC1A(3), ARPC1B(2), ARPC2(5), BAIAP2(2), CFL1(1), DIAPH1(5), GSN(2), LIMK1(8), MYLK(11), OPHN1(4), PIP5K1A(6), PIP5K1B(2), PPP1R12B(4), ROCK1(8), SRC(1), TLN1(16), VCL(6)	65837122	143	97	140	50	22	33	25	23	40	0	0.946	1.000	1.000
429	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(2), ASAH1(1), ATF1(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), CREBBP(15), CRKL(1), DAG1(2), EGR1(3), EGR2(3), EGR3(4), ELK1(4), FRS2(1), GNAQ(1), JUN(3), MAP1B(8), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NTRK1(8), OPN1LW(3), PIK3C2G(8), PIK3CD(6), PTPN11(1), RPS6KA3(8), SHC1(2), SRC(1), TERF2IP(3), TH(2)	65038342	126	97	124	34	33	27	17	24	25	0	0.419	1.000	1.000
430	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(8), AR(6), ESR1(7), ESR2(5), HNF4A(2), NR1D1(5), NR1D2(2), NR1H2(7), NR1H3(2), NR1I2(2), NR1I3(2), NR2C2(2), NR2E1(3), NR2F1(1), NR2F2(1), NR3C1(3), NR4A1(3), NR4A2(3), NR5A1(1), NR5A2(7), PGR(6), PPARA(4), PPARD(2), PPARG(5), RARA(1), RARB(6), RARG(3), ROR1(9), RORA(1), RORC(2), RXRA(2), RXRG(2), THRA(3), THRB(2)	56476040	120	96	119	42	29	19	22	21	29	0	0.864	1.000	1.000
431	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(1), B4GALT1(3), G6PC(2), G6PC2(3), GAA(2), GALE(1), GALK2(4), GALT(2), GANC(4), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), HSD3B7(1), LALBA(1), LCT(17), MGAM(22), PFKL(1), PFKM(8), PFKP(7), PGM1(5), PGM3(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), UGP2(4)	54171946	128	95	125	35	15	27	27	41	18	0	0.319	1.000	1.000
432	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACADVL(5), ACAT1(3), ACOX1(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP4A11(8), CYP4A22(2), EHHADH(4), GCDH(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8)	70206659	137	95	136	33	25	35	34	28	14	1	0.139	1.000	1.000
433	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(5), AKT3(4), BRD4(3), CAP1(3), CBL(4), CDKN2A(1), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), PPYR1(4), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SERPINB6(3), SFN(1), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(6), YWHAB(2), YWHAG(1), YWHAZ(3)	73529147	139	95	138	41	27	41	13	29	28	1	0.652	1.000	1.000
434	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(5), AKT3(4), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PIK3CB(8), PITX2(5), PLD1(7), PLD2(2), PLD3(2), VN1R1(1)	63170641	133	95	132	34	22	39	14	36	22	0	0.228	1.000	1.000
435	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), DAG1(2), DGKA(2), ETFA(1), ITGA9(7), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(4), PDE3A(12), PDE3B(4), PI3(1), PIK3C2G(8), PIK3CD(6), PSME1(1), RIPK3(4), RPS4X(2), SGCB(2)	64828554	128	94	126	40	19	39	14	36	20	0	0.703	1.000	1.000
436	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM2(2), CD3E(3), CD3G(3), ELK1(4), FOS(1), HRAS(2), JUN(3), LAT(1), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), PTPN7(5), RAF1(4), RASA1(2), RELA(3), SHC1(2), SOS1(5), SYT1(2), VAV1(6), ZAP70(3)	56384859	116	93	116	36	23	29	18	25	21	0	0.638	1.000	1.000
437	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(1), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADHA(3), KMO(8), KYNU(3), MAOA(2), MAOB(4), TDO2(2), TPH1(3), WARS2(2)	78967109	145	93	144	54	18	40	26	37	23	1	0.927	1.000	1.000
438	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(7), CALM2(2), ELK1(4), FCER1A(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PAK2(2), PLA2G4A(7), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6)	49282400	114	91	114	27	21	31	19	27	16	0	0.186	1.000	1.000
439	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(2), CDK2(2), CDT1(2), DIAPH2(9), GMNN(2), MCM10(7), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), NACA(8), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), PRIM1(1), RFC1(7), RFC2(1), RFC4(3), RFC5(1), RPA1(1), RPA2(2), RPA3(2), RPA4(3), UBA52(2), UBC(13)	72199391	124	90	123	35	15	40	19	27	22	1	0.752	1.000	1.000
440	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM2(2), CREB1(2), ELK1(4), FOS(1), GNAI1(2), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RAF1(4), RPS6KA3(8), SYT1(2)	47297656	117	90	117	32	27	27	19	23	21	0	0.422	1.000	1.000
441	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	37	AARS2(5), CARS(5), CARS2(5), DARS(4), DARS2(2), EARS2(3), EPRS(11), FARS2(4), FARSA(3), FARSB(5), GARS(2), HARS(1), IARS(8), IARS2(5), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), NARS2(2), PARS2(2), QARS(10), RARS(5), RARS2(3), SARS(4), TARS(8), TARS2(11), VARS(2), VARS2(1), WARS2(2), YARS(4), YARS2(1)	71451664	139	90	137	35	17	51	19	29	23	0	0.367	1.000	1.000
442	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	32	AKT1(2), AKT2(5), AKT3(4), ARHGEF11(6), DLG4(1), GNA13(1), LPA(16), MAP3K5(12), MAPK8(2), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PI3(1), PIK3CB(8), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RDX(3), ROCK1(8), ROCK2(9), SERPINA4(4), SRF(1)	64294127	133	90	132	37	29	38	17	21	28	0	0.471	1.000	1.000
443	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(5), AKT3(4), ANKRD6(5), APC(23), AXIN1(5), AXIN2(5), CER1(2), CSNK1A1(4), CTNNB1(2), DACT1(2), DKK2(1), DKK3(4), DKK4(3), DVL1(2), FSTL1(1), GSK3A(5), GSK3B(2), LRP1(28), MVP(2), NKD1(1), NKD2(2), PSEN1(2), PTPRA(6), SENP2(1), SFRP1(3), WIF1(3)	56778961	125	89	125	38	25	32	17	26	22	3	0.760	1.000	1.000
444	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(7), ACAA1(1), ACAA2(2), ACADS(2), ACAT1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), AUH(1), BCAT1(4), BCAT2(5), BCKDHA(4), BCKDHB(1), DBT(1), DLD(1), EHHADH(4), HADH(2), HADHA(3), HADHB(3), HIBADH(2), HIBCH(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), OXCT2(5), PCCA(4), PCCB(2)	62197409	118	88	115	27	21	34	19	24	20	0	0.193	1.000	1.000
445	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG5(5), ALG6(2), ALG8(2), ALG9(2), B4GALT1(3), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(5), DOLPP1(2), DPAGT1(4), DPM1(4), FUT8(2), GANAB(10), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), RPN1(4), RPN2(2), ST6GAL1(3), STT3B(3)	59247143	124	87	124	30	13	34	34	25	17	1	0.243	1.000	1.000
446	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(23), ASAH1(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(2), GNAQ(1), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PITX2(5), PTX3(1), RHO(2), RYR1(29)	65501142	126	87	125	47	27	28	16	40	14	1	0.918	1.000	1.000
447	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(7), CALM2(2), CD79B(2), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK14(2), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6)	49219771	108	86	108	33	19	27	19	28	15	0	0.630	1.000	1.000
448	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT(1), AGXT2(2), AKR1B10(1), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), BHMT(1), CBS(1), CHKA(1), CHKB(5), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), HSD3B7(1), MAOA(2), MAOB(4), PEMT(1), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), PSPH(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8), TARS2(11)	61019753	123	86	123	38	14	29	23	37	20	0	0.572	1.000	1.000
449	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), GAMT(1), GATM(3), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(4), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), P4HB(2), PYCR1(1), RARS(5)	62223883	128	85	127	38	24	31	39	21	13	0	0.435	1.000	1.000
450	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CDK5(2), F2(2), GNA11(4), GNAI1(2), GNB1(2), HRAS(2), JAK2(7), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(4), MYLK(11), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), SYT1(2)	59850132	116	85	116	34	21	31	18	25	21	0	0.525	1.000	1.000
451	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT(1), AGXT2(2), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), ATP6V0C(1), BHMT(1), CBS(1), CHKA(1), CHKB(5), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), MAOA(2), MAOB(4), PEMT(1), PISD(1), PLCB2(7), PLCG1(8), PLCG2(8), PSPH(1), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8)	59848972	124	85	124	45	19	23	22	34	25	1	0.892	1.000	1.000
452	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	ARSB(3), FUCA1(1), FUCA2(3), GALNS(2), GBA(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NAGLU(2), NEU1(1), NEU3(2), SPAM1(4)	46796057	106	85	107	30	20	31	16	22	17	0	0.420	1.000	1.000
453	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(3), CRK(1), CRKL(1), DOCK1(8), ELK1(4), FOS(1), GAB1(2), HGF(5), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(10), MAPK1(1), MAPK3(1), MAPK8(2), MET(10), PAK1(4), PTK2(7), PTK2B(7), PTPN11(1), RAF1(4), RAP1A(2), RAP1B(1), RASA1(2), SOS1(5), SRC(1), STAT3(5)	58628891	111	85	111	30	26	31	19	18	16	1	0.419	1.000	1.000
454	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(3), G6PC(2), GAA(2), GALE(1), GALK2(4), GALT(2), GANAB(10), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), LALBA(1), LCT(17), MGAM(22), PFKM(8), PFKP(7), PGM1(5), PGM3(2)	45975652	114	84	111	32	15	23	27	34	15	0	0.386	1.000	1.000
455	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(8), ACTG2(4), ADCY3(5), ADCY9(14), AK1(1), ARF1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(3), GNAS(11), PDIA4(7), PLCG1(8), PLCG2(8), PRKCA(4), SEC61A1(4), SEC61A2(4), TRIM23(4)	52958639	124	84	123	30	23	37	19	21	24	0	0.203	1.000	1.000
456	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALNT1(2), B3GALT1(3), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALNT1(1), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT6(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GBGT1(2), GCNT2(1), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGZ(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), UGCG(1)	66934964	112	83	112	29	18	28	28	22	16	0	0.198	1.000	1.000
457	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(6), ALAS2(8), BLVRA(4), BLVRB(1), COX10(7), COX15(3), CP(8), EARS2(3), EPRS(11), FTMT(2), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), MMAB(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UROD(2), UROS(2)	59732475	125	82	124	42	9	36	24	38	17	1	0.884	1.000	1.000
458	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFAT5(7), PDE6A(7), PDE6B(3), PDE6C(6), SLC6A13(4), TF(5)	51432746	103	82	102	36	14	31	14	30	14	0	0.844	1.000	1.000
459	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(13), ACACB(13), ACAT1(3), ACOT12(1), ACSS1(1), ACSS2(2), ACYP1(2), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PCK2(4), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5)	65943923	108	81	107	30	25	28	21	21	13	0	0.313	1.000	1.000
460	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(8), CAPN2(8), CXCR3(6), EGF(5), EGFR(5), HRAS(2), ITGA1(6), ITGB1(5), MAPK1(1), MAPK3(1), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTK2(7), TLN1(16)	47753526	99	79	98	32	20	22	22	19	15	1	0.666	1.000	1.000
461	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), BTRC(4), CDC16(3), CDC20(1), CDC23(2), CUL1(2), CUL2(4), CUL3(5), ITCH(4), SKP1(1), SKP2(2), SMURF1(3), SMURF2(5), TCEB1(1), UBA1(8), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), WWP1(6), WWP2(12)	53352598	99	78	96	22	14	37	15	19	13	1	0.297	1.000	1.000
462	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(6), AASDHPPT(4), AASS(5), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADHA(3), PLOD1(2), PLOD2(2), PLOD3(9), SHMT1(1), SHMT2(4), TMLHE(1)	49117614	99	78	97	33	12	21	28	18	20	0	0.833	1.000	1.000
463	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(3), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(13), ATP7B(6), COX10(7), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1), PPA2(2), SDHB(2), SHMT1(1), UQCRB(1), UQCRC1(1), UQCRFS1(1)	55684794	111	76	111	36	21	35	16	23	16	0	0.706	1.000	1.000
464	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(5), ELK1(4), GNAS(11), GNB1(2), HRAS(2), IGF1R(7), ITGB1(5), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(3), PTPRR(4), RAF1(4), RPS6KA1(7), RPS6KA5(4), SHC1(2), SOS1(5), SRC(1), STAT3(5)	46574076	98	75	96	25	20	26	12	27	13	0	0.378	1.000	1.000
465	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(2), ARSE(4), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(4), DEGS2(1), ENPP7(5), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS1(2), SGMS2(2), SGPP1(2), SGPP2(1), SMPD1(2), SMPD2(2), SMPD3(1), SMPD4(4), SPHK1(1), SPHK2(3), SPTLC1(4), SPTLC2(6), UGCG(1), UGT8(5)	47091390	97	75	95	26	20	28	15	23	11	0	0.304	1.000	1.000
466	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(4), C1GALT1(3), C1GALT1C1(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GCNT3(1), GCNT4(3), OGT(5), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(6), WBSCR17(7)	46701401	103	73	103	38	18	24	16	28	14	3	0.921	1.000	1.000
467	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(23), ATF2(4), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(4), BMPR1A(1), BMPR2(8), CHRD(5), CTNNB1(2), DVL1(2), FZD1(3), GATA4(2), GSK3B(2), MAP3K7(3), MEF2C(4), NKX2-5(1), NOG(1), NPPA(1), RFC1(7), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4)	50555577	100	72	99	32	14	26	13	29	16	2	0.838	1.000	1.000
468	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), FUK(4), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), HSD3B7(1), KHK(4), MPI(2), MTMR1(1), MTMR2(2), MTMR6(3), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(8), PFKP(7), PGM2(5), PMM1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SORD(2), TPI1(2), TSTA3(2)	53022759	97	71	95	27	15	20	14	29	19	0	0.431	1.000	1.000
469	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CLCA1(6), CLCA2(5), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(5), PRKACA(4), PRKACB(1), PRKACG(3), PRKG1(5), PRKG2(8), PRKX(5)	44104497	89	70	88	42	13	21	16	25	14	0	0.996	1.000	1.000
470	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(13), ACAT1(3), ACYP1(2), ADH5(5), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5)	51950911	97	70	96	27	21	28	19	16	13	0	0.369	1.000	1.000
471	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(3), BAD(1), BRAF(5), CREB1(2), CREB3(1), CREB5(4), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), MAP2K1(5), MAP2K2(2), MAP3K8(4), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), SHC1(2), SOS1(5), SOS2(6), TRAF3(3)	42224949	91	70	90	23	17	22	10	20	21	1	0.380	1.000	1.000
472	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(3), CREB1(2), CREB3(1), CREB5(4), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(4), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MKNK1(2), MKNK2(4), MYEF2(3), NFKB1(5), NR2C2(2), SRF(1), TRAF6(4)	46173423	89	70	87	37	15	21	14	22	17	0	0.979	1.000	1.000
473	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), CAPN1(8), ITGA1(6), ITGB1(5), ITGB3(4), PTK2(7), SPTAN1(13), SRC(1), TLN1(16)	41376609	86	70	86	30	19	20	15	17	14	1	0.873	1.000	1.000
474	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(2), AZIN1(3), CBX3(2), CLOCK(3), CRY1(2), CRY2(3), DNAJA1(2), EIF4G2(2), ETV6(4), GSTP1(1), HSPA8(6), IDI1(7), MYF6(5), NCKAP1(9), NR1D2(2), PER1(10), PER2(8), PPP1R3C(3), PPP2CB(2), SF3A3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(4), VAPA(2), ZFR(7)	51576361	96	69	96	32	14	39	15	15	12	1	0.917	1.000	1.000
475	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAA2(2), ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1B10(1), AKR1C4(3), AKR1D1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), HSD3B7(1), LIPA(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SLC27A5(4), SOAT1(2), SOAT2(2), SRD5A1(4)	44785865	91	68	90	25	16	17	26	16	16	0	0.351	1.000	1.000
476	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(15), POLA2(6), POLB(1), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLG(7), POLG2(2), POLH(3), POLI(2), POLK(2), POLL(3), POLM(4), POLQ(12), PRIM1(1), REV1(6), REV3L(17), RFC5(1)	58314418	101	68	99	24	10	25	22	25	18	1	0.457	1.000	1.000
477	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(2), DLG4(1), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), NOS1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), SYT1(2)	36099627	86	68	86	31	18	20	21	15	12	0	0.711	1.000	1.000
478	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(12), DIAPH1(5), GSN(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), MYLK(11), PTK2(7), RAF1(4), ROCK1(8), SHC1(2), SRC(1), TLN1(16)	49041900	88	67	88	27	14	24	15	17	18	0	0.720	1.000	1.000
479	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(7), ACACA(13), ACACB(13), ACAT1(3), ACSS1(1), ACSS2(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), HIBCH(2), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	57129081	88	67	87	28	9	28	18	20	13	0	0.695	1.000	1.000
480	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(6), AP2M1(4), ARF1(2), BAD(1), BTK(7), EEA1(10), GRASP(2), GSK3A(5), GSK3B(2), LYN(6), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PLCG1(8), PRKCE(8), PRKCZ(2), RPS6KB1(4), VAV2(3)	35572963	90	67	88	32	17	19	14	23	17	0	0.902	1.000	1.000
481	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(3), EGF(5), EGFR(5), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	43202467	83	66	82	23	15	17	11	22	18	0	0.540	1.000	1.000
482	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(23), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(13), FZD1(3), GSK3B(2), HDAC1(5), LDB1(1), PITX2(5), TRRAP(18)	46527569	94	66	94	28	15	19	13	28	17	2	0.720	1.000	1.000
483	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(3), AGTR1(4), ATF2(4), CALM2(2), EGFR(5), ELK1(4), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(6), MEF2C(4), MEF2D(3), PAK1(4), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2)	43968525	88	65	87	22	16	27	12	20	13	0	0.277	1.000	1.000
484	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(5), CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(8), MYLK(11), NCF2(7), PAK1(4), PDGFRA(6), PLD1(7), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(13), VAV1(6), WASF1(6)	41206082	92	65	91	30	10	26	23	18	15	0	0.765	1.000	1.000
485	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3)	30931583	81	64	81	27	16	17	17	14	17	0	0.787	1.000	1.000
486	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3)	30931583	81	64	81	27	16	17	17	14	17	0	0.787	1.000	1.000
487	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), APC(23), AXIN1(5), CCND1(1), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(4), GNAI1(2), GSK3B(2), IRAK1(5), LBP(1), MYD88(1), NFKB1(5), PDPK1(2), PPP2CA(3), RELA(3), TIRAP(1), TLR4(15)	36384978	83	64	82	28	11	25	10	25	10	2	0.888	1.000	1.000
488	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(4), CREB1(2), DAXX(2), ELK1(4), HMGN1(1), HRAS(2), MAP2K6(1), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK14(2), MAPKAPK2(1), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MYC(1), PLA2G4A(7), RIPK1(5), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	47613838	89	64	88	23	16	29	10	22	12	0	0.378	1.000	1.000
489	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(23), AXIN1(5), BTRC(4), CCND1(1), CREBBP(15), CSNK1A1(4), CSNK2A1(3), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(2), HDAC1(5), MAP3K7(3), MYC(1), NLK(1), PPARD(2), PPP2CA(3), TLE1(4), WIF1(3)	41357440	87	63	87	27	18	25	10	19	13	2	0.806	1.000	1.000
490	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(5), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), GNAS(11), HRAS(2), MAPK1(1), MAPK14(2), MAPK3(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RPS6KA1(7), RPS6KA5(4), SOS1(5)	35263639	74	62	73	22	17	15	13	13	16	0	0.727	1.000	1.000
491	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(8), IFNA1(1), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL1RN(2), IL6(2), IRAK1(5), IRAK2(4), IRAK3(2), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), TGFB1(2), TGFB2(1), TGFB3(1), TRAF6(4)	38316332	76	62	76	19	14	20	14	11	17	0	0.411	1.000	1.000
492	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PDGFRA(6), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	39513993	79	62	79	20	15	20	9	18	17	0	0.359	1.000	1.000
493	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), BCAT1(4), BCKDHA(4), BCKDHB(1), EHHADH(4), HADHA(3), HADHB(3), HIBADH(2), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), PCCA(4), PCCB(2)	51861515	86	62	85	22	14	22	15	19	16	0	0.413	1.000	1.000
494	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(3), AKR1D1(1), ARSB(3), ARSE(4), CYP11B1(5), CYP11B2(4), HSD11B1(3), HSD11B2(2), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), SRD5A1(4), STS(1), SULT1E1(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3)	38118021	78	60	77	26	8	22	20	20	8	0	0.619	1.000	1.000
495	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(7), ACACA(13), ACADL(1), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	47737000	80	60	79	27	7	28	15	17	13	0	0.829	1.000	1.000
496	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	26	AKT1(2), CABIN1(8), CALM2(2), CAMK1(1), CAMK1G(5), HDAC5(6), IGF1R(7), INSR(11), MAP2K6(1), MAPK14(2), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYT1(2)	42316178	82	59	82	26	7	28	12	23	12	0	0.652	1.000	1.000
497	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(5), C6(8), C7(8), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELP(11), SELPLG(2), VCAM1(7)	35558244	79	59	79	27	9	22	18	22	8	0	0.805	1.000	1.000
498	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(3), ERCC3(5), GTF2E1(2), GTF2E2(3), GTF2F2(1), GTF2H1(2), ILK(3), MNAT1(2), POLR1A(10), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(1), TAF5(4), TAF6(3), TAF7(1), TAF9(2), TBP(2)	49360508	80	59	79	30	10	20	12	18	20	0	0.956	1.000	1.000
499	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	20	CARS(5), DARS(4), EPRS(11), FARS2(4), GARS(2), HARS(1), IARS(8), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), QARS(10), RARS(5), SARS(4), TARS(8), WARS2(2), YARS(4)	43348029	89	58	88	23	9	32	13	21	14	0	0.420	1.000	1.000
500	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(7), ABP1(1), ACADL(1), ACADSB(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), MLYCD(4), UPB1(3)	41022518	76	58	75	28	10	20	18	15	13	0	0.865	1.000	1.000
501	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(2), ACP5(3), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), PON1(4)	41404914	82	58	81	26	12	20	15	25	10	0	0.536	1.000	1.000
502	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(7), ABP1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), HIBCH(2), MLYCD(4), SRM(4), UPB1(3)	37855468	72	58	71	22	9	17	19	14	13	0	0.602	1.000	1.000
503	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), HRH1(4), HRH2(4), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4)	35139381	77	58	77	32	25	11	11	20	10	0	0.703	1.000	1.000
504	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(23), ASAH1(1), CASP3(1), CERK(2), CREB1(2), CREB3(1), CREB5(4), CXCL2(1), DAG1(2), EPHB2(5), FOS(1), GNAQ(1), ITPKA(1), ITPKB(8), JUN(3), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1)	37588224	76	58	76	19	16	17	11	18	13	1	0.413	1.000	1.000
505	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), ELAVL1(4), FLT1(5), FLT4(3), HIF1A(4), HRAS(2), KDR(8), NOS3(3), PLCG1(8), PRKCA(4), PTK2(7), SHC1(2)	42847256	76	58	76	27	12	26	13	13	11	1	0.850	1.000	1.000
506	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(3), APOA4(1), CETP(3), CYP7A1(3), DGAT1(2), HMGCR(5), LCAT(1), LDLR(6), LIPC(2), LPL(1), LRP1(28), SCARB1(5), SOAT1(2)	38168040	73	57	73	24	18	10	20	14	10	1	0.715	1.000	1.000
507	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(2), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SP1(6), SP3(7), SYT1(2)	28015703	66	56	65	19	7	17	11	17	14	0	0.635	1.000	1.000
508	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(4), BLVRB(1), CP(8), EPRS(11), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UROD(2), UROS(2)	39399533	76	56	75	30	5	22	17	22	9	1	0.952	1.000	1.000
509	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(1), EPHB2(5), F2(2), F2RL1(1), F2RL2(2), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(4), MAPK8(2), MYEF2(3), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RAF1(4), RASAL1(5), SRC(1), TEC(6), VAV1(6)	39214541	72	56	72	21	20	19	12	12	9	0	0.441	1.000	1.000
510	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(7), ACADS(2), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), L2HGDH(2), OXCT1(5), PDHA1(2), PDHA2(4), PDHB(1), SDHB(2)	36716133	69	55	68	22	13	17	14	15	10	0	0.632	1.000	1.000
511	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PNPLA3(3), SH3GLB1(2), TAT(3), TPO(8)	47296678	75	55	74	21	17	16	11	16	14	1	0.532	1.000	1.000
512	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(4), ALOX5(3), CYP1A2(2), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), HSD3B7(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	34366289	70	55	70	20	8	20	15	18	9	0	0.453	1.000	1.000
513	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM2(2), CAPN2(8), EP300(13), HDAC1(5), HDAC2(2), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SYT1(2)	33472411	65	55	65	23	8	15	12	15	15	0	0.905	1.000	1.000
514	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(6), AP2M1(4), BIN1(2), CALM2(2), DNM1(6), EPN1(4), EPS15(6), PICALM(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYNJ1(4), SYNJ2(4), SYT1(2)	32273756	61	55	61	18	9	15	16	11	10	0	0.572	1.000	1.000
515	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), GLCE(4), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), NDST1(4), NDST2(1), NDST3(5)	29006389	66	54	64	21	15	17	4	17	13	0	0.757	1.000	1.000
516	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), CTNNA1(7), CTNNA2(14), CTNNB1(2), PTK2(7), SRC(1), VCL(6)	27042218	66	53	65	25	17	14	6	13	15	1	0.899	1.000	1.000
517	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(4), CD33(2), CD5(3), CD7(1), IFNA1(1), IFNG(2), IL12B(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(15), TLR7(9), TLR9(2)	26556607	64	53	63	22	7	15	17	14	11	0	0.710	1.000	1.000
518	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(23), CREBBP(15), EP300(13), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4)	34639973	75	53	75	17	13	19	10	18	14	1	0.422	1.000	1.000
519	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(10), F2(2), F2R(4), GNA12(2), GNA13(1), GNAI1(2), GNAQ(1), GNB1(2), MAP3K7(3), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2B(7), ROCK1(8)	31023450	68	52	68	18	17	14	14	9	14	0	0.432	1.000	1.000
520	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), P4HB(2), SLC23A1(2), SLC23A2(8), SLC2A3(3)	37226074	70	52	70	26	12	16	18	11	13	0	0.853	1.000	1.000
521	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ACAA2(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), SOAT2(2), SRD5A1(4)	32736870	64	51	63	24	13	11	20	8	12	0	0.831	1.000	1.000
522	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AGPS(1), CHPT1(4), ENPP2(12), ENPP6(2), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PPAP2A(2), PPAP2C(1)	33162628	62	51	62	17	6	19	14	14	9	0	0.423	1.000	1.000
523	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(2), MRPS7(3), RPL10L(1), RPL12(1), RPL13A(4), RPL18(1), RPL18A(4), RPL19(2), RPL22L1(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36A(2), RPL37A(1), RPL3L(3), RPL41(1), RPL7(1), RPL8(2), RPL9(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS5(6), RPS6(4), RPS8(1), RPS9(2)	32146887	60	51	60	16	13	15	12	13	7	0	0.498	1.000	1.000
524	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(4), AGT(3), AGTR1(4), AGTR2(2), COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), REN(1)	37339412	69	50	69	22	12	16	16	13	12	0	0.590	1.000	1.000
525	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(7), AGT(3), AGTR2(2), EDN1(5), EDNRA(3), EDNRB(2), EGF(5), EGFR(5), FOS(1), HRAS(2), JUN(3), MYC(1), NFKB1(5), PLCG1(8), PRKCA(4), RELA(3)	29202165	59	50	58	19	10	15	7	16	11	0	0.734	1.000	1.000
526	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(5), EGFR(5), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), PTPRB(12), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SPRY1(7), SPRY2(2), SPRY3(6), SRC(1)	36090969	64	50	63	26	14	14	9	18	9	0	0.916	1.000	1.000
527	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(9), AKT1(2), ATM(23), BAX(3), CDKN1A(1), CPB2(4), CSNK1A1(4), FHL2(2), HIF1A(4), IGFBP3(1), MAPK8(2), MDM2(3), NFKBIB(2), NQO1(1)	27218151	61	49	60	19	9	20	8	11	13	0	0.865	1.000	1.000
528	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), HDAC5(6), MEF2A(6), MEF2C(4), MEF2D(3), PPARA(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), SLC2A4(3), SYT1(2)	29818299	63	49	63	19	4	17	10	20	12	0	0.625	1.000	1.000
529	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(2), CREBBP(15), EP300(13), NCOA3(9), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RARA(1), RXRA(2)	29299005	62	47	62	18	11	15	11	11	14	0	0.650	1.000	1.000
530	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5), MASP1(8), MASP2(2), MBL2(2)	30324581	58	47	58	19	9	17	14	11	7	0	0.781	1.000	1.000
531	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ABP1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AOC2(6), AOC3(3), ASPA(4), CNDP1(7), DDC(4), HAL(7), HARS(1), HNMT(2), MAOA(2), MAOB(4), PRPS2(1)	33799259	68	47	67	22	14	14	15	11	14	0	0.652	1.000	1.000
532	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(24), MAP2(18), PPP2CA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2), PRKCE(8)	26140728	64	46	64	19	7	22	10	13	11	1	0.841	1.000	1.000
533	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(5), AKT1(2), ASAH1(1), GNAI1(2), GNB1(2), ITGAV(7), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(6), PLCB1(13), PRKCA(4), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(1), SRC(1)	33296479	61	46	61	17	18	14	6	12	11	0	0.529	1.000	1.000
534	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(6), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), XYLB(2)	38200469	66	46	66	28	3	20	10	22	11	0	0.971	1.000	1.000
535	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(7), ABCG2(1), BCHE(6), CES1(4), CES2(2), CYP3A4(4), CYP3A5(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2)	33175893	61	46	61	24	6	13	14	21	7	0	0.848	1.000	1.000
536	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), SELE(2), SELL(6), SELP(11)	23557680	55	46	55	18	7	12	12	14	10	0	0.746	1.000	1.000
537	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(14), CR2(5), HLA-DRB1(10), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8)	21066449	52	45	52	22	4	16	14	10	7	1	0.926	1.000	1.000
538	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(5), EPHB1(12), ITGA1(6), ITGB1(5), L1CAM(10), LYN(6), RAP1B(1), SELP(11)	22796856	59	45	59	21	15	11	12	17	3	1	0.782	1.000	1.000
539	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(5), F2(2), F2R(4), FGA(7), FGB(1), FGG(7), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5)	19608259	53	45	53	21	5	13	12	13	10	0	0.940	1.000	1.000
540	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(1), ATIC(3), FTCD(2), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1)	27277911	52	45	51	16	5	18	9	6	14	0	0.690	1.000	1.000
541	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CYP2C19(6), CYP2C9(3), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1)	44002064	57	45	56	14	9	16	10	14	7	1	0.379	1.000	1.000
542	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1)	33332815	53	45	53	24	9	12	7	14	11	0	0.988	1.000	1.000
543	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C8B(3), C9(5), MASP1(8)	29488256	57	44	57	18	8	18	14	10	7	0	0.754	1.000	1.000
544	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(5), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), ILVBL(5), PANK1(2), PANK2(1), PANK4(6), UPB1(3), VNN1(3)	24213883	51	44	51	18	10	10	11	11	9	0	0.803	1.000	1.000
545	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(1), ATIC(3), ATP6V0C(1), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1)	25943183	51	44	50	16	4	18	9	6	14	0	0.703	1.000	1.000
546	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(23), AXIN1(5), BTRC(4), CTNNB1(2), DLL1(5), DVL1(2), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(2)	27683188	56	44	56	20	8	15	11	14	6	2	0.928	1.000	1.000
547	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), NCK1(2), NCKAP1(9), NTRK1(8), PIR(2), PSMA7(3), WASF1(6), WASF2(3), WASF3(5), WASL(4)	22171512	59	43	58	15	6	22	14	6	10	1	0.503	1.000	1.000
548	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(2), EGFR(5), IGF1R(7), MYC(1), POLR2A(6), PPP2CA(3), PRKCA(4), TEP1(16), TERT(2), TNKS(5), XRCC5(3)	36158068	54	43	53	21	6	13	8	16	10	1	0.928	1.000	1.000
549	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME3(4), PGK1(6), PGK2(1), PKLR(5), TKT(3), TKTL1(3), TKTL2(3), TPI1(2)	28478508	48	42	48	16	9	16	9	8	6	0	0.564	1.000	1.000
550	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(13), ABCB4(10), ABCC1(12), ABCC3(9), GSTP1(1)	21319735	54	42	54	19	8	14	13	10	9	0	0.621	1.000	1.000
551	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IGF1R(7), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1)	29017443	47	41	47	14	7	14	6	10	10	0	0.681	1.000	1.000
552	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(9), NCOR2(8), POLR2A(6), RARA(1), RXRA(2), TBP(2)	35558465	50	41	50	28	5	10	9	13	13	0	0.999	1.000	1.000
553	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	24	BAG4(1), BIRC2(3), BIRC3(4), CASP3(1), CFLAR(1), JUN(3), MAP3K3(1), MAP3K7(3), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR2C2(2), RALBP1(3), RIPK1(5), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	33666759	54	41	53	18	11	18	8	5	12	0	0.762	1.000	1.000
554	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME2(2), ME3(4), PGK1(6), PKLR(5), TKT(3), TPI1(2)	25415479	43	39	43	15	9	16	6	8	4	0	0.584	1.000	1.000
555	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(2), DHCR24(4), DHCR7(1), EBP(1), FDFT1(4), FDPS(5), GGCX(3), GGPS1(2), HMGCR(5), HSD17B7(1), IDI1(7), IDI2(1), LSS(3), NQO1(1), NSDHL(3), PMVK(2), SQLE(2), VKORC1(1)	27365371	51	39	50	20	10	18	5	12	6	0	0.881	1.000	1.000
556	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(5), GALNT2(2), GALNT3(3), GALNT4(1), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), WBSCR17(7)	21132495	47	39	47	14	10	6	9	15	6	1	0.613	1.000	1.000
557	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), COPA(8), GBF1(8), GPLD1(5), KDELR1(2), KDELR2(2), KDELR3(2)	23442358	42	38	42	12	6	18	6	5	5	2	0.520	1.000	1.000
558	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(3), EGF(5), EGFR(5), MET(10), PDGFRA(6), PRKCA(4), SH3GLB1(2), SH3GLB2(1), SH3KBP1(9), SRC(1)	28180489	50	38	49	24	9	13	6	14	8	0	0.987	1.000	1.000
559	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(13), ACACB(13), FASN(14), MCAT(2), OLAH(1), OXSM(3)	21673574	46	38	46	14	7	14	7	9	9	0	0.579	1.000	1.000
560	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(5), IARS(8), IARS2(5), ILVBL(5), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1), VARS(2), VARS2(1)	22928506	45	38	45	14	8	13	9	9	6	0	0.656	1.000	1.000
561	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), NPAS2(8), NR1D1(5), PER1(10), PER2(8), PER3(9)	23701460	54	38	53	20	11	14	8	13	8	0	0.921	1.000	1.000
562	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(3), DPM2(1), ELK1(4), FOS(1), HRAS(2), JUN(3), KLK2(3), MAP2K1(5), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(8), RAF1(4), SHC1(2), SOS1(5)	21242440	45	38	45	13	10	10	3	12	10	0	0.557	1.000	1.000
563	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(15), EP300(13), LPL(1), NCOA1(5), NCOA2(6), PPARG(5), RXRA(2)	26452967	47	38	46	17	9	9	8	10	11	0	0.908	1.000	1.000
564	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	24690044	46	37	46	13	6	15	12	8	5	0	0.639	1.000	1.000
565	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	35822664	43	37	43	10	4	14	11	10	3	1	0.409	1.000	1.000
566	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(5), CSF3(2), HLA-DRB1(10), IFNA1(1), IFNG(2), IL11(1), IL12B(2), IL15(3), IL1A(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1), LTA(2), TGFB1(2), TGFB2(1), TGFB3(1)	17950081	43	37	43	17	5	8	10	11	9	0	0.894	1.000	1.000
567	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(11), PTPRU(10), REG1A(1), STAT1(4), STAT2(5), TYK2(8)	17648282	41	37	39	12	7	5	11	9	9	0	0.655	1.000	1.000
568	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(11), GNB1(2), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	21135409	47	36	47	15	12	10	8	8	9	0	0.775	1.000	1.000
569	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(15), DAXX(2), HRAS(2), PAX3(4), PML(3), RARA(1), SIRT1(2), SP100(9), TNFRSF1A(4), TNFRSF1B(2)	22068175	44	35	42	12	10	11	5	10	8	0	0.561	1.000	1.000
570	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), PRKCE(8), SOD1(1)	11331454	39	34	39	16	5	13	9	9	3	0	0.894	1.000	1.000
571	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACOT11(3), ACYP1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), FN3K(3), GCDH(2), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1)	36893595	41	34	41	13	6	14	5	12	3	1	0.735	1.000	1.000
572	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(2), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), GSK3B(2), IGF1R(7), INPPL1(6), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4)	21396445	43	34	43	16	6	19	8	4	5	1	0.850	1.000	1.000
573	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELE(2), SELL(6)	17658423	38	34	38	15	4	9	6	12	7	0	0.890	1.000	1.000
574	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(6), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3)	25327862	43	34	43	22	2	10	8	17	6	0	0.984	1.000	1.000
575	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(6), IDI1(7), LSS(3), NSDHL(3), PMVK(2), SQLE(2)	18731033	40	33	39	14	7	14	4	9	6	0	0.796	1.000	1.000
576	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12)	23689146	39	33	38	11	6	8	6	9	9	1	0.689	1.000	1.000
577	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), CHSY1(3), DSE(11), UST(2), XYLT1(4), XYLT2(5)	17147745	35	33	35	16	15	8	3	6	3	0	0.890	1.000	1.000
578	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(5), AFMID(1), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	19478363	37	33	37	13	7	15	6	4	5	0	0.603	1.000	1.000
579	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(13), CPT1A(6), LEP(1), LEPR(7), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	21034208	38	33	38	16	5	10	6	8	9	0	0.956	1.000	1.000
580	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), PANK1(2), PANK2(1), PANK4(6), UPB1(3)	19314824	38	33	38	15	6	8	8	9	7	0	0.898	1.000	1.000
581	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1)	23169551	45	33	45	19	8	15	8	5	9	0	0.876	1.000	1.000
582	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(2), CCL2(1), CCR5(1), CXCR4(3), FOS(1), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(8), PRKCA(4), PTK2B(7), SYT1(2)	19426835	37	32	37	11	7	8	6	6	10	0	0.678	1.000	1.000
583	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(2), CD3E(3), CD3G(3), CD86(6), CTLA4(1), HLA-DRB1(10), ICOS(3), ITK(7), LCK(2), PTPN11(1)	12270485	38	32	38	11	3	13	9	8	5	0	0.590	1.000	1.000
584	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(5), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	18551378	36	32	36	12	7	15	6	3	5	0	0.531	1.000	1.000
585	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(6), MBTPS1(3), MBTPS2(6), SCAP(2), SREBF1(4), SREBF2(6)	15959746	33	32	33	12	7	7	12	4	3	0	0.608	1.000	1.000
586	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD4(4), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	16053129	40	32	40	15	3	11	10	8	8	0	0.770	1.000	1.000
587	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), DPM2(1), HRAS(2), KLK2(3), NTRK1(8), PLCG1(8), PRKCA(4), SHC1(2), SOS1(5)	16716162	35	32	35	10	6	7	6	9	7	0	0.572	1.000	1.000
588	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
589	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(5), EGFR(5), MAP2K1(5), MAPK14(2), NCOR2(8), RARA(1), RXRA(2), THRA(3), THRB(2)	20008441	33	31	32	13	4	6	7	7	9	0	0.919	1.000	1.000
590	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
591	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(4), ICAM1(2), ITGAL(5), ITGAM(6), ITGB2(8), SELE(2), SELL(6)	15567842	33	31	33	12	4	8	6	6	9	0	0.764	1.000	1.000
592	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	12	AKT1(2), BCAR1(6), ILK(3), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(2), PTK2(7), SHC1(2), SOS1(5)	19858403	35	31	35	10	6	8	5	9	6	1	0.646	1.000	1.000
593	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
594	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	18626179	36	30	36	10	4	15	7	8	2	0	0.633	1.000	1.000
595	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CAMKK1(3), CAMKK2(4), CREB1(2), SYT1(2)	16458973	37	30	37	12	6	9	7	8	7	0	0.736	1.000	1.000
596	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), IDI1(7), LSS(3), NQO1(1), NQO2(2), PMVK(2), SQLE(2), VKORC1(1)	15580074	33	29	32	12	7	11	4	7	4	0	0.804	1.000	1.000
597	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	18215527	33	29	33	13	5	7	8	6	7	0	0.869	1.000	1.000
598	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(10), EGF(5), EGFR(5), HGS(6), TF(5), TFRC(2)	18311915	33	28	32	11	6	9	6	6	6	0	0.830	1.000	1.000
599	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), ABP1(1), AOC2(6), AOC3(3), CES1(4), DDHD1(4), ESCO1(4), ESCO2(1), LIPA(4), PLA1A(3), PNPLA3(3), PPME1(2), SH3GLB1(2)	35941837	42	28	42	14	5	9	12	11	4	1	0.777	1.000	1.000
600	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(3), CD3G(3), CD4(4), HLA-DRB1(10), LCK(2), PTPRC(8), ZAP70(3)	12005239	33	28	33	18	2	8	9	7	7	0	0.989	1.000	1.000
601	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(3), CD3G(3), HLA-A(3), ICAM1(2), ITGAL(5), ITGB2(8), PRF1(2)	11901415	29	27	28	15	4	8	4	9	4	0	0.940	1.000	1.000
602	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(10), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF5(2), GSK3B(2)	16390263	30	27	30	12	3	13	5	6	3	0	0.922	1.000	1.000
603	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), EHHADH(4), HADHA(3)	17306805	29	26	28	11	5	5	9	4	6	0	0.816	1.000	1.000
604	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(17), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2)	14373556	30	25	30	11	3	11	9	6	0	1	0.822	1.000	1.000
605	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GCNT2(1), ST3GAL6(1), ST8SIA1(1)	20186507	28	25	28	12	6	8	4	7	3	0	0.856	1.000	1.000
606	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5)	18080986	30	24	30	16	6	8	2	8	6	0	0.990	1.000	1.000
607	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), GPI(3), HK1(3), PFKL(1), PGK1(6), PKLR(5), TPI1(2)	12797847	23	22	23	10	2	7	4	5	5	0	0.824	1.000	1.000
608	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(3), ANKRD1(2), ATF3(2), CYR61(3), IFNG(2), IFRD1(2), IL18(2), IL1A(1), IL1R1(1), NR4A3(5), WDR1(1)	15390973	24	22	24	12	3	7	5	8	1	0	0.950	1.000	1.000
609	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(2), CD4(4), HLA-DRB1(10), IL4(1), IL5RA(4), IL6(2)	6922598	24	22	24	11	1	4	6	6	7	0	0.935	1.000	1.000
610	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), WASF1(6), WASL(4)	11850785	27	21	27	12	3	12	6	0	5	1	0.932	1.000	1.000
611	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(1), GPR161(6), GPR34(4), GPR39(3), GPR45(2), GPR65(1), GPR75(3)	14262818	25	20	25	11	2	4	2	13	4	0	0.894	1.000	1.000
612	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), PAK1(4), PDGFRA(6), WASL(4)	14109738	28	19	28	10	4	16	2	0	6	0	0.737	1.000	1.000
613	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(3), SNCA(1), SNCAIP(7), UBE2F(1), UBE2L3(1), UBE2L6(2)	9042881	20	19	20	10	3	8	4	4	1	0	0.955	1.000	1.000
614	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(1), KERA(3), LUM(2)	5254266	10	7	10	7	2	5	2	1	0	0	0.955	1.000	1.000
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(1), FUT1(1), GCNT2(1), ST8SIA1(1)	7748235	4	4	4	6	0	1	0	3	0	0	0.998	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	2217960	3	3	3	2	0	2	0	1	0	0	0.946	1.000	1.000
