rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(3), ADORA3(2), P2RY1(2), P2RY2(1), P2RY6(2)	1486127	12	11	12	1	5	2	3	2	0	0	0.0453	0.0200	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	127344	2	2	2	0	0	0	0	0	2	0	0.860	0.0464	1.000
3	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(1), RAB27A(2), RAB3A(1), RAB6A(1)	1075847	7	7	7	1	1	0	3	1	2	0	0.499	0.0539	1.000
4	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACP5(1), ACP6(4), ACPP(2), ACPT(1), ENPP1(6), ENPP3(1), FLAD1(1), MTMR2(2), MTMR6(4), PHPT1(1)	3795599	24	19	22	1	9	1	4	7	3	0	0.0143	0.0979	1.000
5	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(5), OAT(1), PRODH(1)	1428662	11	11	11	2	5	0	0	3	3	0	0.453	0.100	1.000
6	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), HADHA(3)	1371296	7	7	7	0	1	0	2	3	0	1	0.193	0.137	1.000
7	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(1)	1613515	11	10	10	1	5	2	3	1	0	0	0.197	0.145	1.000
8	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF3(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), E2F2(2), MDM2(1), PRB1(2)	1911045	12	10	12	1	4	0	2	1	4	1	0.203	0.149	1.000
9	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(3), FH(2), IDH1(2), IDH2(4), MDH1(1), SDHB(2), SUCLA2(1)	2250565	16	15	16	2	8	1	1	1	5	0	0.113	0.149	1.000
10	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE1(2), CCNE2(1), CDK2(1), CDK4(1), CDKN2A(2), E2F2(2), PRB1(2)	2277484	12	11	12	0	4	0	2	2	3	1	0.0594	0.179	1.000
11	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS2(4), SULT1A2(2), SULT1E1(2)	1526973	10	9	9	1	4	0	3	2	1	0	0.253	0.193	1.000
12	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(2), SHMT1(1), SHMT2(3)	1068963	7	6	7	0	2	2	2	1	0	0	0.113	0.205	1.000
13	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(3), ALDOC(1), TPI1(3)	981919	7	6	7	1	3	0	0	1	3	0	0.438	0.226	1.000
14	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GBA3(1), GGT1(2), SHMT1(1), SHMT2(3)	1419223	8	7	8	0	2	2	2	2	0	0	0.101	0.245	1.000
15	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(1), DAG1(6), ITPKA(3), ITPKB(3)	1528954	14	11	14	3	5	1	1	2	5	0	0.543	0.246	1.000
16	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(1), CUL1(4), FBXW7(3), TFDP1(1)	2094098	11	10	11	0	4	1	2	2	2	0	0.0817	0.251	1.000
17	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), MST1(5), MST1R(1), TNF(1)	1648155	9	8	8	0	2	0	1	1	5	0	0.164	0.256	1.000
18	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(2), IL1B(1), IL5RA(2)	1343993	7	7	7	1	3	0	1	1	2	0	0.472	0.297	1.000
19	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASDHPPT(1), AASS(2), KARS(2)	1742497	7	7	7	1	4	0	1	2	0	0	0.417	0.329	1.000
20	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(3)	414450	3	3	3	1	2	0	0	1	0	0	0.680	0.331	1.000
21	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), UGDH(1)	988320	5	5	5	1	3	0	0	1	1	0	0.572	0.332	1.000
22	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFS1(2), NDUFS2(1), NDUFV1(2)	1772256	15	15	14	5	4	1	1	3	6	0	0.819	0.338	1.000
23	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	540014	3	3	3	1	1	0	1	1	0	0	0.685	0.346	1.000
24	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(1), CUL1(4), NEDD8(1), RBX1(1), SKP2(1), TFDP1(1)	2160824	11	10	11	0	4	1	1	2	3	0	0.0567	0.364	1.000
25	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(2), BCMO1(1), RDH5(2)	973757	5	5	5	1	2	0	0	3	0	0	0.570	0.368	1.000
26	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(2), KARS(2)	1184417	5	5	5	1	4	0	1	0	0	0	0.571	0.371	1.000
27	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACP5(1), ACPP(2), ACPT(1), ENPP1(6), ENPP3(1), FLAD1(1)	2446799	13	10	13	1	5	1	1	4	2	0	0.160	0.376	1.000
28	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(3), HADHB(1), HSD17B10(2), HSD17B4(1), MECR(3), PPT2(1)	2149226	12	10	12	0	5	1	4	2	0	0	0.0308	0.411	1.000
29	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(1), FH(2), IDH2(4), MDH1(1), OGDH(7), SDHA(4), SUCLA2(1)	2376974	23	19	23	6	10	3	5	0	5	0	0.355	0.416	1.000
30	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(2), GAD1(4), GAD2(2), GGT1(2)	1465236	12	11	12	3	7	0	2	2	1	0	0.440	0.437	1.000
31	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(2), CDK2(1), CUL1(4), SKP2(1), TFDP1(1)	2165221	10	9	10	0	5	1	1	2	1	0	0.0724	0.469	1.000
32	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(2)	663188	4	4	4	1	3	0	0	0	1	0	0.568	0.494	1.000
33	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), UGDH(1)	1250882	5	5	5	1	3	0	0	1	1	0	0.578	0.499	1.000
34	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(4), EHHADH(2), HADHA(3)	1228249	9	8	8	2	4	0	1	3	1	0	0.464	0.501	1.000
35	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(6), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3)	2600528	21	18	21	3	10	1	6	1	3	0	0.0711	0.505	1.000
36	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(5), TGM2(1)	1267683	7	7	7	0	6	0	0	0	1	0	0.106	0.556	1.000
37	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC3G(2)	1844010	10	10	10	2	3	3	0	4	0	0	0.539	0.560	1.000
38	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(3), CRY1(1), CRY2(1), CSNK1E(3), PER1(2)	2178928	10	10	10	2	3	0	4	3	0	0	0.404	0.571	1.000
39	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(2), GOT1(2), GOT2(2), LDHB(1), MPST(2)	1713007	10	8	10	1	7	0	1	1	1	0	0.163	0.578	1.000
40	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(5), ITGA1(3), ITGB1(5), L1CAM(1), LYN(1), SELP(2)	3957248	19	17	19	3	5	4	4	1	5	0	0.282	0.580	1.000
41	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(2), PLCB1(2), TUB(1)	1796701	7	6	7	1	1	1	2	3	0	0	0.402	0.593	1.000
42	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL4(3), ST6GALNAC2(2), ST6GALNAC4(1)	1424223	6	5	6	1	2	1	3	0	0	0	0.316	0.600	1.000
43	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(1), HS3ST3A1(1), XYLT1(2), XYLT2(2)	1713734	9	8	9	2	4	1	2	0	2	0	0.289	0.608	1.000
44	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(1), HS3ST3A1(1), XYLT1(2), XYLT2(2)	1713734	9	8	9	2	4	1	2	0	2	0	0.289	0.608	1.000
45	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD3G(1), CD4(2)	813329	4	4	4	1	3	0	0	1	0	0	0.612	0.627	1.000
46	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(1)	1576282	5	5	5	1	2	1	1	0	1	0	0.546	0.628	1.000
47	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(3), GRIA2(2)	951284	6	5	6	2	4	0	0	0	2	0	0.681	0.632	1.000
48	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3G(1)	289764	1	1	1	0	1	0	0	0	0	0	0.779	0.636	1.000
49	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(5), NRG2(1), NRG3(4), PSEN1(2)	2271563	14	12	14	3	5	2	4	2	1	0	0.382	0.636	1.000
50	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2)	759463	2	2	2	1	0	0	0	1	1	0	0.944	0.642	1.000
51	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(1), SNCAIP(2), UBE2F(1), UBE2G1(1), UBE2L3(2)	1608877	9	8	9	2	4	0	3	1	1	0	0.398	0.642	1.000
52	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(1), IL10(1), IL10RA(5), JAK1(4), STAT1(2), STAT3(1), STAT5A(3), TNF(1)	3082739	19	15	19	4	8	3	2	2	4	0	0.373	0.659	1.000
53	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(2), CASP8AP2(6), CASP9(2), CES1(1)	2817176	16	14	16	3	5	2	3	4	2	0	0.378	0.666	1.000
54	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(1), GREB1(7), MTA1(6), MTA3(1), PDZK1(1)	2802030	18	12	17	2	8	3	2	2	3	0	0.130	0.685	1.000
55	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(2), GLS(5), GOT1(2)	1956341	10	10	10	2	6	1	0	2	1	0	0.471	0.687	1.000
56	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(5), GLS2(1), GLUD2(11)	1141741	17	16	11	5	7	0	0	8	2	0	0.609	0.703	1.000
57	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(1)	452887	3	3	3	2	0	0	1	2	0	0	0.879	0.712	1.000
58	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(3), CYP2A6(3), CYP2A7(1), XDH(2)	2012718	9	8	9	2	4	1	3	1	0	0	0.370	0.715	1.000
59	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), ST3GAL3(2), ST3GAL4(3)	1982355	10	7	10	0	6	1	2	1	0	0	0.0358	0.716	1.000
60	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), GOT2(2)	1183183	7	6	7	1	6	0	0	0	1	0	0.282	0.725	1.000
61	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	563456	1	1	1	1	0	0	1	0	0	0	0.958	0.737	1.000
62	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(3), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(3)	2549067	15	14	15	4	4	4	2	4	1	0	0.431	0.749	1.000
63	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT6(1), ST3GAL3(2)	1287140	5	4	5	0	3	1	0	1	0	0	0.197	0.755	1.000
64	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAA2(1), EHHADH(2), HADHA(3), HADHB(1)	2116983	11	9	11	2	5	0	2	3	1	0	0.392	0.761	1.000
65	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(3), ALDOC(1), GOT1(2), GOT2(2), GPT(2), MDH1(1), ME1(1), ME2(1), ME3(3), PKLR(1), RPE(2), RPIA(1), TKT(2), TPI1(3)	4561062	25	20	25	3	11	1	4	3	6	0	0.0414	0.769	1.000
66	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(3), ALDOC(1), GOT1(2), GOT2(2), GPT(2), MDH1(1), ME1(1), ME3(3), PGK2(1), PKLR(1), RPE(2), RPIA(1), TKT(2), TKTL2(1), TPI1(3)	5093936	26	21	26	3	11	2	4	3	6	0	0.0327	0.779	1.000
67	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT2(2), ST3GAL3(2), ST3GAL4(3)	1815004	7	6	7	0	4	1	1	1	0	0	0.111	0.783	1.000
68	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	504993	2	2	2	0	2	0	0	0	0	0	0.599	0.783	1.000
69	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(1), SPCS1(1)	783248	3	2	3	0	2	0	1	0	0	0	0.388	0.790	1.000
70	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), PAPSS2(4), SULT1A2(2), SULT1E1(2)	2323315	11	9	10	2	5	0	3	2	1	0	0.326	0.817	1.000
71	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(4), DPYS(4), ENPP1(6), ENPP3(1), PANK2(2), PANK3(3), PANK4(2), PPCS(1)	3520548	24	17	24	5	6	2	3	5	8	0	0.377	0.817	1.000
72	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3G(1), CD4(2), CD58(1)	1570622	6	5	6	1	3	1	0	1	1	0	0.485	0.821	1.000
73	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(2), CYP17A1(2), HSD11B1(1)	1745742	8	6	8	2	3	2	1	1	1	0	0.444	0.822	1.000
74	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	ENDOG(1), HMGB1(3), HMGB2(2), TOP2A(5), TOP2B(4)	2431618	15	14	15	4	4	1	3	3	4	0	0.756	0.823	1.000
75	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(6), CBS(1), CTH(2), DNMT1(9), DNMT3A(7), DNMT3B(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), MTR(2)	4413510	40	27	40	9	16	2	9	5	8	0	0.232	0.828	1.000
76	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8)	4232655	22	16	22	3	9	2	1	4	6	0	0.169	0.831	1.000
77	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT6(3), GALNT7(1), GALNT9(1), ST3GAL4(3), WBSCR17(4)	3664020	21	18	20	4	9	2	3	2	5	0	0.243	0.833	1.000
78	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(2), AMT(1), ATIC(1), GART(3), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(2), SHMT1(1), SHMT2(3), TYMS(1)	4513107	20	17	20	3	6	2	4	6	2	0	0.156	0.833	1.000
79	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	755171	1	1	1	1	0	0	0	1	0	0	0.960	0.841	1.000
80	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1), OXCT1(1)	850287	2	2	2	1	1	0	0	1	0	0	0.831	0.849	1.000
81	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(2), HSD17B1(1), HSD17B4(1), HSD17B7(1)	2036168	7	6	7	2	2	1	2	0	2	0	0.684	0.850	1.000
82	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	426932	1	1	1	1	1	0	0	0	0	0	0.908	0.851	1.000
83	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GBGT1(1), GLA(1), NAGA(1), ST3GAL4(3)	2547254	8	8	8	1	4	1	1	1	1	0	0.233	0.857	1.000
84	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2)	599962	2	2	2	0	2	0	0	0	0	0	0.504	0.861	1.000
85	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1)	2020386	15	13	15	4	8	1	2	4	0	0	0.375	0.866	1.000
86	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1)	2020386	15	13	15	4	8	1	2	4	0	0	0.375	0.866	1.000
87	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(3), CDKN1A(1), EPOR(3), HIF1A(2), JAK2(3), NFKB1(3), NFKBIA(2), RELA(2), SOD2(1)	3235338	20	15	20	4	8	3	1	3	4	1	0.359	0.871	1.000
88	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1), KERA(1)	905113	2	2	2	1	1	0	1	0	0	0	0.784	0.875	1.000
89	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(2), ITGB1(5), PIK3CA(2), PIK3R1(3), PTEN(5), PTK2(1), SHC1(1), SOS1(3)	4892430	23	21	23	9	2	1	6	4	10	0	0.906	0.879	1.000
90	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADVL(3), ACSL1(2), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(2), HADHA(3), PECR(2), SCP2(3), SLC25A20(1)	4248069	24	16	24	3	13	0	4	4	2	1	0.0767	0.880	1.000
91	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(1), ACO2(3), ACSS1(3), ACSS2(1), FH(2), IDH1(2), IDH2(4), MDH1(1), SUCLA2(1)	3355716	22	17	22	5	12	2	1	1	6	0	0.282	0.882	1.000
92	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), JAK1(4), JAK2(3), STAT1(2)	2054182	10	10	10	3	3	3	1	2	1	0	0.738	0.892	1.000
93	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(3), NFKBIA(2), PLCB1(2), RELA(2)	2082004	9	8	9	3	2	2	1	2	2	0	0.785	0.896	1.000
94	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3G(1), IL2RA(1), TGFB1(2), TGFBR1(1), TGFBR2(1), TOB1(3)	2680355	9	8	9	2	3	0	3	2	1	0	0.410	0.897	1.000
95	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(3), NOX1(2), RELA(2), TNF(1), XDH(2)	2523760	12	8	12	3	5	2	1	1	3	0	0.525	0.899	1.000
96	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(4), ACOX1(3), ACOX3(6), ELOVL5(1), ELOVL6(3), FADS1(1), FASN(9), HADHA(3), PECR(2)	3765169	32	21	32	7	13	1	9	5	4	0	0.129	0.900	1.000
97	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), NR3C1(2), RXRA(2), TNF(1)	1456174	7	7	7	4	2	1	1	1	2	0	0.901	0.900	1.000
98	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT2(2)	1554570	3	3	3	0	1	0	0	2	0	0	0.468	0.902	1.000
99	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), CTH(2), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(1), MPST(2), SULT1C2(1), SULT1C4(3), SULT4A1(1)	3168418	17	13	17	3	10	0	1	3	3	0	0.215	0.904	1.000
100	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), VAMP2(1)	816024	4	3	4	2	1	0	1	2	0	0	0.856	0.907	1.000
101	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP68(2), SRP72(1)	1895947	5	5	5	1	3	0	0	2	0	0	0.542	0.914	1.000
102	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(2), CREBBP(5), HMGB2(2), NME1(1), PRF1(2)	2685108	14	13	14	4	5	0	3	2	4	0	0.550	0.915	1.000
103	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(1), HPRT1(1), IMPDH1(1), MTHFD2(1), OAZ1(1), POLB(2), POLD1(4), POLG(6), PRPS2(3), RRM1(3)	3211632	25	19	25	5	12	3	2	3	5	0	0.242	0.920	1.000
104	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(1), CHEK1(2), NEK1(1), WEE1(1)	1802733	5	4	5	1	3	1	0	1	0	0	0.614	0.923	1.000
105	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ACP5(1), ACP6(4), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), CMBL(2), CYP3A4(2), CYP3A43(2), CYP3A7(1), DHRS1(1), DHRS2(1), PON2(2), PON3(2)	4572936	31	22	30	8	15	2	3	3	8	0	0.359	0.928	1.000
106	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1), PNPO(1), PSAT1(2)	1217894	4	4	4	2	3	0	0	0	1	0	0.866	0.931	1.000
107	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(3), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2)	2315705	12	11	12	3	4	1	2	2	3	0	0.574	0.934	1.000
108	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(1), POLB(2), POLD1(4), POLD2(2), POLD4(1), POLG(6), POLG2(1), POLI(3), POLK(2), POLM(2), POLQ(8), PRIM1(1), PRIM2(3), REV1(2), REV3L(4), RFC5(2)	10322769	49	36	49	7	17	5	7	9	11	0	0.0901	0.939	1.000
109	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PTK2B(1)	1699498	3	3	3	1	1	0	2	0	0	0	0.695	0.940	1.000
110	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(3), JAK3(4), STAT3(1), TYK2(2)	3000537	14	11	13	3	7	2	1	2	2	0	0.358	0.941	1.000
111	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFLAR(1), PDE6D(1)	969818	2	2	2	2	1	0	0	0	1	0	0.953	0.941	1.000
112	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(4), EHHADH(2), HADHA(3), HSD17B10(2), HSD17B4(1), NTAN1(2), SIRT2(1), SIRT7(1)	2998258	16	12	15	3	7	1	3	3	2	0	0.295	0.943	1.000
113	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(7)	2080103	10	10	10	3	2	0	2	5	1	0	0.700	0.946	1.000
114	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(1), CTH(2), GGT1(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), PAPSS2(4), SCLY(3), SEPHS1(1)	3137157	24	20	24	7	10	1	6	3	4	0	0.482	0.949	1.000
115	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	NR1I3(1), PTGS1(1), PTGS2(2)	1334274	4	3	4	1	3	0	0	1	0	0	0.601	0.951	1.000
116	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(1), IL9(1)	1552463	4	3	4	1	2	0	0	1	1	0	0.619	0.952	1.000
117	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(1), F2R(1), FGA(1), FGB(1), PLAT(2), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(1)	3374383	14	13	14	3	6	1	3	3	1	0	0.434	0.953	1.000
118	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(1), GBA3(1), MPO(3), PRDX6(2), TPO(1)	2127895	11	10	11	4	2	2	2	4	1	0	0.725	0.954	1.000
119	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CSF1(1), FCGR3A(2), IL1B(1), SELL(2), SPN(1), TGFB1(2), TNF(1), TNFRSF1B(1), TNFSF8(2)	3415354	18	14	18	4	8	1	2	2	5	0	0.280	0.954	1.000
120	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(2), ERBB3(3), NRG1(4)	2592926	11	9	11	3	4	0	2	2	3	0	0.571	0.956	1.000
121	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), SDHA(4), SDHB(2), SDHD(2)	1659163	9	8	9	3	3	0	3	2	1	0	0.635	0.958	1.000
122	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(5), G6PD(1), GCLC(3), GGT1(2), GPX1(1), GPX4(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(4), MGST2(1), OPLAH(5), TXNDC12(1)	5665573	40	28	40	8	15	4	10	8	3	0	0.0848	0.959	1.000
123	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(5), G6PD(1), GCLC(3), GGT1(2), GPX1(1), GPX4(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(4), MGST2(1)	4653549	31	23	31	7	12	3	7	7	2	0	0.200	0.961	1.000
124	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), METTL2B(1), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), WBSCR22(1)	3564059	19	17	19	7	9	3	0	1	6	0	0.690	0.962	1.000
125	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), IL10(1)	1000097	3	2	3	0	3	0	0	0	0	0	0.351	0.964	1.000
126	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(2), CYP17A1(2), CYP21A2(1), HSD11B1(1)	2381224	8	7	8	6	3	0	1	1	3	0	0.944	0.966	1.000
127	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(2), CYP17A1(2), CYP21A2(1), HSD11B1(1)	2381224	8	7	8	6	3	0	1	1	3	0	0.944	0.966	1.000
128	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ6(4), NDUFB11(1)	1033613	6	5	6	3	4	0	0	1	1	0	0.814	0.969	1.000
129	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(3), ASPH(1), EP300(11), HIF1A(2), NOS3(3), P4HB(2), VHL(2)	4302239	24	18	24	6	10	3	3	1	6	1	0.591	0.970	1.000
130	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(2), EGFR(2), TFRC(2)	3231944	8	7	8	0	4	0	0	3	1	0	0.103	0.970	1.000
131	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), PTK2B(1), SHC1(1), SOS1(3), SRC(2)	2219673	8	6	8	2	4	1	1	0	2	0	0.514	0.970	1.000
132	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), LDLR(2), LPL(1)	1339551	4	4	4	3	0	0	1	1	2	0	0.923	0.971	1.000
133	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), ITGB1(5), KLRC1(1), KLRC2(1), KLRC3(1), LAT(2), PAK1(1), PIK3CA(2), PIK3R1(3), PTK2B(1), RAC1(1), SYK(2), VAV1(1)	4722741	23	18	23	5	6	1	4	4	7	1	0.561	0.971	1.000
134	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(5), ITGB2(3), SELE(1), SELL(2)	3066363	17	15	17	7	5	1	4	3	4	0	0.836	0.974	1.000
135	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(1), JAK1(4), JAK2(3), TYK2(2)	2643022	11	8	10	3	5	2	1	1	2	0	0.565	0.975	1.000
136	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(1), JAK1(4), JAK2(3), TYK2(2)	2643022	11	8	10	3	5	2	1	1	2	0	0.565	0.975	1.000
137	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), CHST1(1), CHST2(3), CHST6(1), ST3GAL3(2), ST3GAL4(3)	3123278	14	11	14	3	6	3	4	1	0	0	0.242	0.976	1.000
138	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(4), DPYS(4), ENPP1(6), ENPP3(1), ILVBL(2), PANK2(2), PANK3(3), PANK4(2), PPCDC(1), PPCS(1)	4378563	27	19	27	8	7	3	3	6	8	0	0.604	0.976	1.000
139	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), DDOST(1), DPAGT1(2), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1)	5050110	18	12	18	2	8	0	5	0	5	0	0.0760	0.976	1.000
140	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), GBA3(1), MPO(3), PRDX2(1), PRDX6(2), TPO(1)	2453389	11	10	11	4	2	2	2	4	1	0	0.736	0.978	1.000
141	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(3), AGTR2(1), EDNRB(3), EGF(2), EGFR(2), FOS(1), HRAS(1), NFKB1(3), PLCG1(1), RELA(2)	5174234	24	16	24	4	10	2	3	4	5	0	0.148	0.979	1.000
142	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3G(1), CD86(3), CTLA4(2), ICOS(1), PIK3CA(2), PIK3R1(3), PTPN11(2)	3211255	14	14	14	4	2	1	5	3	3	0	0.737	0.980	1.000
143	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(3), DHCR24(1), DHCR7(1), EBP(1), FDFT1(1), FDPS(1), GGCX(2), HMGCR(4), HSD17B7(1), IDI2(1), LSS(3), MVD(1), MVK(2), PMVK(1), SQLE(1), TM7SF2(2)	4920757	28	21	28	7	11	6	6	2	3	0	0.353	0.981	1.000
144	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(1), MDH1(1), ME1(1), PC(6), SLC25A1(1)	2343056	14	12	14	6	5	1	1	3	4	0	0.784	0.984	1.000
145	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22RA1(4), JAK1(4), JAK2(3), JAK3(4), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), TYK2(2)	4705775	30	21	29	7	14	7	2	3	4	0	0.354	0.985	1.000
146	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(1), EHHADH(2), HADHA(3), SDHB(2)	1973624	8	7	8	3	3	0	2	2	1	0	0.711	0.985	1.000
147	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), GCH1(1)	1677869	10	8	10	5	4	0	3	1	2	0	0.717	0.985	1.000
148	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(9), PTGDR(2), PTGFR(2), PTGIR(1), TBXA2R(1)	2838495	17	12	17	6	9	2	2	2	2	0	0.479	0.986	1.000
149	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(7), ALOX15(2), ALOX15B(1), ALOX5(3), DPEP1(1), GGT1(2), LTA4H(1), PLA2G6(3), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2)	3880223	28	21	28	6	15	6	1	4	2	0	0.178	0.987	1.000
150	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), JAK1(4), JAK2(3), JAK3(4), PIAS3(4), PTPRU(1), SRC(2), STAT3(1)	3869007	21	14	21	5	11	3	2	2	3	0	0.313	0.987	1.000
151	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCNB1(1), CCNE1(2), CCNH(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), RBL1(2), TFDP1(1)	4055857	13	13	13	2	8	0	1	2	2	0	0.232	0.987	1.000
152	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(5), FOS(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(3), JAK3(4), PTPN11(2), RAF1(2), SHC1(1), SOS1(3), SRF(1), STAT3(1)	6053924	31	24	31	7	10	3	5	5	8	0	0.298	0.988	1.000
153	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT2(2), GBGT1(1), GLA(1), NAGA(1)	2700577	5	5	5	1	3	0	0	1	1	0	0.457	0.988	1.000
154	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(2), MUT(1)	1241432	4	4	4	2	3	0	1	0	0	0	0.802	0.988	1.000
155	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(3), AKT3(1), BPNT1(2), PIK3CA(2), PIK3CD(1), PTEN(5), PTK2B(1), RBL2(4), SHC1(1), SOS1(3)	5139696	24	20	24	6	4	1	8	4	7	0	0.540	0.989	1.000
156	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(4), HDC(2), PNMT(1), TPH1(2)	1531680	10	9	10	7	8	0	1	0	1	0	0.912	0.990	1.000
157	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(4), LARS2(1)	2520799	6	6	6	2	2	0	1	1	2	0	0.881	0.990	1.000
158	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25C(1), CSK(1), PTPRA(1), SRC(2)	2337292	6	6	6	2	2	2	1	0	1	0	0.724	0.990	1.000
159	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA3(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDNRB(3), HSD11B1(1), PLA2G4A(3), PTGDR(2), PTGFR(2), PTGIR(1), PTGIS(3), PTGS1(1), PTGS2(2), SCGB1A1(1), TBXAS1(2)	5198367	30	24	30	8	14	2	3	6	5	0	0.291	0.990	1.000
160	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3G(1), CD4(2), PTPRC(2), ZAP70(2)	2274487	7	6	7	3	4	1	0	0	2	0	0.843	0.991	1.000
161	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), ALAS2(2), GATA1(5), UROD(1)	2027039	9	9	9	8	4	0	3	0	2	0	0.977	0.991	1.000
162	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3)	3079349	20	16	20	6	10	1	3	6	0	0	0.450	0.991	1.000
163	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1)	4446148	15	11	15	3	9	2	1	3	0	0	0.325	0.992	1.000
164	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3G(1), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2)	2687387	11	9	11	6	4	0	2	2	3	0	0.889	0.992	1.000
165	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), FADD(1), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1), TRAF2(1)	2138309	7	6	7	3	1	2	1	1	2	0	0.874	0.992	1.000
166	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), KEAP1(2)	1977647	3	3	3	4	1	0	0	0	2	0	0.985	0.992	1.000
167	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(1), IFNAR1(2), NFKB1(3), RELA(2)	2794431	10	8	10	4	3	2	1	0	4	0	0.825	0.993	1.000
168	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR1H3(1), NR1H4(1), RXRA(2)	1370574	6	5	6	3	4	0	0	1	1	0	0.727	0.993	1.000
169	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(3), CREBBP(5), EP300(11), IKBKB(3), IL1B(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), NR3C1(2), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(2), TNF(1)	7514794	42	29	42	9	14	6	7	6	8	1	0.357	0.993	1.000
170	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(3), CREBBP(5), EP300(11), FADD(1), IKBKB(3), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1)	5659937	34	25	34	8	12	4	5	4	9	0	0.476	0.993	1.000
171	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(5), EP300(11), IL2RG(1), IL7R(1), JAK1(4), JAK3(4), NMI(1), PIK3CA(2), PIK3R1(3), PTK2B(1), STAT5A(3), STAT5B(2)	7077946	38	28	38	7	16	2	6	5	9	0	0.234	0.994	1.000
172	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(2), GOT2(2), PAH(2), YARS2(1)	2196060	8	8	8	4	3	1	0	2	2	0	0.879	0.994	1.000
173	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), HRAS(1), NFKB1(3), NFKBIA(2), PLCB1(2), RAF1(2), RELA(2), TNF(1)	3907580	14	11	14	4	3	2	1	3	5	0	0.734	0.994	1.000
174	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(1), HRAS(1), JAK2(3), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2)	4481043	18	13	18	4	7	3	1	1	6	0	0.486	0.994	1.000
175	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3G(1), CD4(2), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2)	2826825	13	10	13	5	6	0	2	2	3	0	0.701	0.994	1.000
176	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), FOS(1), HRAS(1), IL2RA(1), IL2RB(3), IL2RG(1), JAK1(4), JAK3(4), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2)	5952946	33	22	33	8	16	1	3	4	9	0	0.313	0.995	1.000
177	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CAPN2(5), EP300(11), NFATC1(1), NFATC2(3), PPP3CA(3), PPP3CB(1)	6126239	30	23	29	7	15	2	4	3	6	0	0.448	0.995	1.000
178	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), NFYC(1)	1674889	3	3	3	3	1	0	1	0	1	0	0.975	0.995	1.000
179	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(3), IFNGR1(1), IL12RB1(3), IL12RB2(1), IL2RA(1), IL4R(1)	3199690	10	9	10	6	4	1	2	0	3	0	0.965	0.996	1.000
180	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACP5(1), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), CYP2A13(3), CYP2A6(3), CYP2A7(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(1), CYP2F1(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), CYP51A1(3)	7406185	33	25	33	8	15	2	9	2	5	0	0.225	0.996	1.000
181	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(5), FOS(1), HRAS(1), IGF1R(4), IRS1(1), PIK3CA(2), PIK3R1(3), PTPN11(2), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1)	6240224	28	23	28	9	8	2	5	4	9	0	0.694	0.996	1.000
182	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(2), BNIP1(1), SEC22B(1), SNAP29(1), STX10(3), STX11(1), STX12(1), STX17(1), STX18(1), STX2(2), STX4(1), STX5(1), TSNARE1(1), USE1(1), VAMP2(1), VTI1B(1)	4246661	20	19	20	5	9	1	6	2	2	0	0.263	0.996	1.000
183	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	TAX1BP3(1), UBE2C(1), UBE2G1(1), UBE2I(1), UBE2J2(1), UBE2L3(2), UBE2N(2), UBE3A(2)	2652208	11	10	11	4	7	0	1	3	0	0	0.682	0.996	1.000
184	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHKA(1), PCYT1A(2), PEMT(3), SLC18A3(2)	1770595	8	6	8	4	5	1	1	0	1	0	0.760	0.997	1.000
185	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), B4GALT5(1), GALNT10(2), GALNT11(2), GALNT14(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT5(2), GALNT6(3), GALNT7(1), GALNT9(1), GALNTL5(1), GCNT3(2), GCNT4(1), OGT(2), ST6GALNAC1(1), WBSCR17(4)	8154530	35	27	33	5	14	1	4	7	9	0	0.0807	0.997	1.000
186	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), RECK(1), TIMP2(1)	1912138	4	4	4	4	3	0	0	0	1	0	0.969	0.997	1.000
187	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3G(1), HLA-A(1), ICAM1(1), ITGAL(3), ITGB2(3), PRF1(2)	2201598	12	11	12	5	6	0	2	3	0	1	0.717	0.997	1.000
188	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), CASP1(1), CASP10(2), CASP9(2), PRF1(2)	3226782	11	10	11	6	5	0	1	2	3	0	0.945	0.997	1.000
189	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1)	2210626	7	7	7	3	2	1	2	1	1	0	0.800	0.997	1.000
190	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(11), ESR1(1), PELP1(2), SRC(2)	3778221	21	17	21	6	10	2	3	2	4	0	0.637	0.997	1.000
191	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(1), C6(2), C7(2), C8A(1)	3171740	9	7	9	2	5	0	1	3	0	0	0.466	0.997	1.000
192	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(3), MAP3K14(2), NFKB1(3), RELA(2), TNFRSF13B(1), TRAF2(1), TRAF5(2)	3691812	14	12	14	4	6	1	1	1	5	0	0.648	0.997	1.000
193	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2R(1), F2RL3(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(5), PLA2G4A(3), PLCB1(2), PTGS1(1), PTK2(1), RAF1(2), SRC(2), SYK(2), TBXAS1(2)	6136136	29	24	29	7	10	3	4	6	6	0	0.399	0.997	1.000
194	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(2), ITPKA(3), PLCB1(2), PLCB2(4), TRH(2), VIP(1)	2803878	15	11	15	6	8	1	2	1	3	0	0.724	0.997	1.000
195	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(3), IKBKB(3), MAP3K1(7), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), TNFAIP3(2)	4609244	24	20	24	5	10	2	4	3	5	0	0.338	0.997	1.000
196	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), EPOR(3), FOS(1), HRAS(1), JAK2(3), PLCG1(1), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2)	5467347	25	18	25	6	9	2	3	4	7	0	0.456	0.998	1.000
197	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(4), JAK2(3), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(1)	3491043	20	15	20	6	9	2	2	3	4	0	0.538	0.998	1.000
198	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH2(1), HMGCL(1), OXCT1(1)	1831848	3	3	3	2	1	0	0	1	1	0	0.911	0.998	1.000
199	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(4), STAT1(2), TYK2(2)	2741554	10	9	9	4	5	0	1	2	2	0	0.712	0.998	1.000
200	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGEF2(3), CLTA(1), CLTB(1), COPA(3), GBF1(6), GPLD1(3), KDELR1(1), KDELR3(2)	4091798	22	21	22	8	9	2	2	5	4	0	0.805	0.998	1.000
201	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL10(1), IL16(2), IL9(1), LTA(1), TNF(1)	2499051	6	5	6	3	2	0	1	1	2	0	0.885	0.998	1.000
202	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2)	3417727	15	14	15	7	2	2	6	2	3	0	0.908	0.998	1.000
203	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(2)	2028158	6	6	6	4	1	1	2	1	1	0	0.917	0.998	1.000
204	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(5), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	2461382	15	9	15	6	7	1	3	2	2	0	0.842	0.998	1.000
205	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(1)	2542111	9	6	9	5	4	1	0	2	2	0	0.936	0.998	1.000
206	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), BAD(1), CASP9(2), CHUK(3), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(3), RELA(2)	3561230	19	16	19	8	6	1	5	3	4	0	0.900	0.998	1.000
207	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(2), CAMP(1), CREB3(3), RAF1(2), SNX13(3), SRC(2)	2864638	15	13	15	7	4	2	2	5	2	0	0.946	0.998	1.000
208	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(2), PPOX(1), UROD(1)	1932796	5	5	5	8	2	0	2	0	1	0	0.998	0.998	1.000
209	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(1), FDFT1(1), FDPS(1), HMGCR(4), LSS(3), MVD(1), MVK(2), PMVK(1), SQLE(1)	3362703	18	13	18	6	9	4	2	0	3	0	0.647	0.998	1.000
210	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	JUNB(2), MAF(1), MAP2K3(2), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	3076285	14	11	14	6	3	2	3	3	3	0	0.852	0.998	1.000
211	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(2), CA1(1), CA5A(1), CA5B(1), CA6(1), CA7(2), CA8(1), CA9(2), CPS1(2), CTH(2), GLS(5), GLS2(1), GLUL(2)	4782839	24	21	24	7	10	2	2	4	6	0	0.600	0.999	1.000
212	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	3219335	16	14	16	5	7	0	2	4	3	0	0.614	0.999	1.000
213	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), BAD(1), HRAS(1), IGF1R(4), IRS1(1), PIK3CA(2), PIK3R1(3), RAF1(2), SHC1(1), SOS1(3)	4756555	19	16	19	9	5	1	5	3	5	0	0.913	0.999	1.000
214	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), DPM2(1), HRAS(1), KLK2(1), MAP2K2(1), RAF1(2)	2095150	7	7	7	5	4	0	0	2	1	0	0.918	0.999	1.000
215	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP9(2), DAXX(2), FASLG(2), MAPKAPK3(1), TNF(1)	2844601	10	7	10	4	3	0	3	1	3	0	0.798	0.999	1.000
216	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), HRAS(1), NFKB1(3), NFKBIA(2), PAK1(1), PIK3CA(2), PIK3R1(3), RAC1(1), RAF1(2), RELA(2), TFDP1(1)	5109106	24	21	24	6	9	1	4	4	6	0	0.536	0.999	1.000
217	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), GPT(2), LDHB(1)	2264562	8	7	8	6	3	0	1	3	1	0	0.970	0.999	1.000
218	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(3), GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1)	3327956	13	10	13	8	4	2	1	3	3	0	0.983	0.999	1.000
219	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), RAC1(1)	3375095	12	10	12	7	3	0	4	2	3	0	0.975	0.999	1.000
220	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BAD(1), CASP9(2), CDC42(1), CHUK(3), HRAS(1), NFKB1(3), PIK3CA(2), PIK3R1(3), RAC1(1), RAF1(2), RALBP1(4), RALGDS(1), RELA(2), RHOA(2)	4866217	29	20	29	8	13	1	6	3	6	0	0.453	0.999	1.000
221	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(5), FOS(1), HRAS(1), INS(3), INSR(3), IRS1(1), PIK3CA(2), PIK3R1(3), PTPN11(2), RAF1(2), RASA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1)	6428798	31	23	31	9	11	2	6	4	8	0	0.573	0.999	1.000
222	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK4(4), EIF2B5(1), EIF2S3(1), EIF5(1), GSK3B(2), PPP1CA(2)	2906434	11	8	11	9	5	0	2	2	2	0	0.997	0.999	1.000
223	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNGR1(1), JAK1(4), JAK2(3), PTPRU(1), STAT1(2)	2878754	13	12	13	5	5	3	1	2	2	0	0.792	0.999	1.000
224	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(1), PON2(2), PON3(2), RDH11(2), RDH13(1)	2267437	9	8	9	7	6	1	0	1	1	0	0.970	0.999	1.000
225	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL2RG(1), IL4R(1), IRS1(1), JAK1(4), JAK3(4), SHC1(1), STAT6(4)	3747544	17	15	17	8	7	1	3	2	4	0	0.778	0.999	1.000
226	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	3376044	16	14	16	5	7	0	2	4	3	0	0.604	0.999	1.000
227	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(3), FADD(1), IKBKB(3), IL1R1(1), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1B(1), TRADD(1)	6181577	34	26	34	9	12	4	6	4	7	1	0.502	0.999	1.000
228	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(1), NOTCH1(8), PSEN1(2)	2379737	13	12	13	5	5	2	4	1	1	0	0.647	0.999	1.000
229	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(5), FASN(9), MCAT(2), OLAH(1), OXSM(2)	4119084	24	21	24	8	11	1	7	2	3	0	0.447	0.999	1.000
230	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	GOT1(2), GOT2(2), PAH(2)	2086042	6	6	6	6	3	0	0	2	1	0	0.975	0.999	1.000
231	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	IL9(1), TGFB1(2)	2113684	3	2	3	4	1	0	0	1	1	0	0.974	0.999	1.000
232	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), FDPS(1), HMGCR(4), LSS(3), MVD(1), MVK(2), NQO2(2), PMVK(1), SQLE(1)	2830258	17	12	17	6	8	4	2	1	2	0	0.625	0.999	1.000
233	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), RAC1(1), WASF1(1)	2057652	7	6	7	5	2	1	2	1	1	0	0.961	0.999	1.000
234	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB4(1), RPN1(1), RPN2(1), UBE3A(2)	3279896	10	9	10	4	3	1	2	2	2	0	0.812	0.999	1.000
235	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), GNAS(3), XPO1(3)	2424362	8	7	8	5	3	1	2	1	1	0	0.975	0.999	1.000
236	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA6(1), PSMA7(1), PSMB1(2), PSMB4(1), PSMD1(1), PSMD11(1), PSMD12(1), PSMD2(3), PSMD6(1)	4038292	13	10	13	7	6	1	2	1	3	0	0.936	0.999	1.000
237	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(4), PTPRU(1), STAT1(2), TYK2(2)	3159231	11	9	10	6	6	0	1	2	2	0	0.842	0.999	1.000
238	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(5), ALDH18A1(1), ARG1(1), ARG2(1), CKB(2), CPS1(2), GATM(3), NAGS(1), OAT(1), OTC(1), SMS(1)	4473133	19	17	19	7	10	3	0	2	4	0	0.726	1.000	1.000
239	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(3), MPO(3), MTHFR(1), PRDX6(2), SHMT1(1), SHMT2(3), TPO(1)	2941343	16	15	15	6	6	2	4	3	1	0	0.615	1.000	1.000
240	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), MBTPS1(1), MBTPS2(1), SCAP(3), SREBF1(3), SREBF2(3)	3107600	13	13	13	5	3	4	0	4	2	0	0.773	1.000	1.000
241	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(1), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(2), PTK2(1), PXN(1), SRC(2)	4889837	16	15	16	6	6	1	2	2	5	0	0.748	1.000	1.000
242	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(1), IL10(1), LTA(1), PDGFA(1), TGFB1(2), TNF(1)	3387860	9	6	9	3	6	0	0	0	3	0	0.587	1.000	1.000
243	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(5), FOS(1), HRAS(1), JAK2(3), MPL(2), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), THPO(2)	7550316	36	24	36	9	13	2	5	6	10	0	0.524	1.000	1.000
244	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(3), MPO(3), PRDX2(1), PRDX6(2), SHMT1(1), SHMT2(3), TPO(1)	3000805	16	15	15	6	5	2	4	4	1	0	0.637	1.000	1.000
245	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25C(1), SHH(1), XPO1(3)	2192221	7	6	7	3	3	0	2	2	0	0	0.823	1.000	1.000
246	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(3), ITGAM(4), ITGB2(3), SELE(1), SELL(2)	2666711	14	13	14	7	6	1	4	2	1	0	0.828	1.000	1.000
247	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CREBBP(5), EP300(11), MAP3K7(1), SKIL(1), TGFB1(2), TGFBR1(1), TGFBR2(1)	6464735	23	18	23	7	7	2	5	3	5	1	0.754	1.000	1.000
248	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F2R(1), F5(3), F7(2), FGA(1), FGB(1), PROS1(2), TFPI(1)	4135651	13	13	13	6	5	0	4	1	3	0	0.913	1.000	1.000
249	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(2), HRAS(1), IGF1R(4), PIK3CA(2), PIK3R1(3), SHC1(1), SOD2(1)	3340025	15	14	14	9	8	1	3	1	2	0	0.968	1.000	1.000
250	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(1), IKBKB(3), JAK2(3), NFKB1(3), NFKBIA(2), RELA(2), TNF(1), TNFRSF1B(1), USH1C(2), WT1(1)	4420405	20	17	20	9	7	4	2	3	4	0	0.935	1.000	1.000
251	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(3), IKBKB(3), LTA(1), MAP3K1(7), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(1), TRAF1(2), TRAF2(1)	5691354	30	22	30	7	13	4	5	3	5	0	0.341	1.000	1.000
252	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(3), F2(1), F2RL2(1), F2RL3(1), MAP2K5(3), MAPK7(3), MYEF2(1), PLD1(2), PLD2(1), PTK2(1), RAF1(2), RASAL1(4), SRC(2), VAV1(1)	6983507	26	22	25	7	10	4	5	5	2	0	0.389	1.000	1.000
253	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(6), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), MDM2(1)	4352180	13	12	13	6	8	0	0	2	3	0	0.840	1.000	1.000
254	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(2), AMT(1), ATIC(1), GART(3), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(2), SHMT1(1), SHMT2(3), TYMS(1)	4800582	20	17	20	6	6	2	4	6	2	0	0.571	1.000	1.000
255	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(5), DAXX(2), HRAS(1), PAX3(1), PML(1), SP100(2), TNF(1), TNFRSF1B(1)	4598496	14	11	14	5	5	0	3	1	5	0	0.799	1.000	1.000
256	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAS(3), GNB1(2), HRAS(1), LIMK1(6), NOX1(2), PIK3C2G(6), PLCB1(2), PPP1R12B(1), PTK2(1), RAF1(2), ROCK2(4)	6406393	32	22	32	8	13	4	6	6	3	0	0.428	1.000	1.000
257	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(2), AKT1(1), ATM(6), CDKN1A(1), CPB2(1), CSNK1A1(1), CSNK1D(1), HIC1(1), HIF1A(2), IGFBP3(1), MDM2(1)	5049774	18	14	18	9	10	0	3	2	2	1	0.885	1.000	1.000
258	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1)	3803757	17	14	17	5	8	5	2	1	1	0	0.487	1.000	1.000
259	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1)	3803757	17	14	17	5	8	5	2	1	1	0	0.487	1.000	1.000
260	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), SHMT1(1)	3803757	17	14	17	5	8	5	2	1	1	0	0.487	1.000	1.000
261	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CMAS(1), CYB5R1(3), GFPT1(3), GNE(1), HK1(1), HK2(2), MTMR2(2), MTMR6(4), NAGK(2), NANS(2), NPL(4), PGM3(1), PHPT1(1), RENBP(2), UAP1(2)	7267695	32	21	31	9	19	1	4	5	3	0	0.359	1.000	1.000
262	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(1), ENPP1(6), ENPP3(1), NADSYN1(1), NMNAT2(1), NNT(2)	3680640	13	9	13	6	6	1	0	4	2	0	0.847	1.000	1.000
263	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(2), EGFR(2), HRAS(1), PTPRB(3), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SPRY2(1), SPRY4(2), SRC(2)	6303865	23	18	23	6	9	2	2	5	5	0	0.489	1.000	1.000
264	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), POLR2A(4), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	3259252	10	7	10	7	3	0	3	1	3	0	0.957	1.000	1.000
265	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(3), IKBKB(3), MAP3K1(7), MAP3K5(1), MAP4K5(2), NFKB1(3), NFKBIA(2), RELA(2), TRAF2(1)	4931442	25	18	25	9	15	1	2	2	5	0	0.733	1.000	1.000
266	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GLB1(1), GNS(1), IDUA(5), LCT(5), NAGLU(4)	3684891	17	14	14	8	7	0	2	6	2	0	0.900	1.000	1.000
267	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), CR2(4), FCGR2B(2), ICAM1(1), ITGAL(3), ITGB2(3), PTPRC(2)	3824168	16	15	16	7	7	1	3	3	2	0	0.843	1.000	1.000
268	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(1), CASP10(2), CASP9(2), PRF1(2), SCAP(3), SREBF1(3), SREBF2(3)	4692653	17	15	17	7	6	4	1	3	3	0	0.844	1.000	1.000
269	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(1), PPP1CA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2)	4473253	15	12	15	8	7	0	3	2	3	0	0.946	1.000	1.000
270	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2B(1), CAMK4(1), CAMKK1(5), CAMKK2(2)	2968512	16	12	16	7	7	2	4	2	1	0	0.724	1.000	1.000
271	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOC3(1), CETP(1), CYP7A1(2), DGAT1(2), HMGCR(4), LCAT(2), LDLR(2), LPL(1), LRP1(14), SCARB1(1)	6910626	36	24	35	9	18	6	4	4	4	0	0.174	1.000	1.000
272	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC3(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), LMNA(3), LMNB2(1), PRF1(2)	4872496	15	12	15	8	7	0	2	2	4	0	0.922	1.000	1.000
273	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), DSE(1), UST(1), XYLT1(2), XYLT2(2)	3580972	14	11	14	7	6	1	4	1	2	0	0.739	1.000	1.000
274	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3G(1), CD4(2), IL12RB1(3), IL12RB2(1), JAK2(3), TYK2(2)	3741341	14	9	13	7	9	2	0	1	2	0	0.909	1.000	1.000
275	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(6), CDC25C(1), CHEK1(2), MYT1(7), WEE1(1)	3474724	17	13	17	8	12	0	0	4	1	0	0.871	1.000	1.000
276	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PLCG1(1), VAV1(1)	3234863	10	10	10	6	1	1	4	3	1	0	0.970	1.000	1.000
277	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(6), CDC25C(1), CDK2(1), CDK4(1), CHEK1(2), MYT1(7), WEE1(1)	4225345	19	15	19	8	13	0	0	4	2	0	0.820	1.000	1.000
278	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(6), CDKN2A(2), MDM2(1), PIK3CA(2), PIK3R1(3), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), RAC1(1), TWIST1(1)	4907932	21	16	21	7	9	0	5	3	4	0	0.714	1.000	1.000
279	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(5), PIGB(2), PIGF(1), PIGK(2), PIGL(1), PIGN(3), PIGO(2), PIGQ(3), PIGS(1), PIGU(1), PIGX(1)	6121761	26	22	26	6	12	4	4	4	2	0	0.237	1.000	1.000
280	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), IARS2(1), ILVBL(2), LARS(4), LARS2(1), VARS(3), VARS2(5)	4696305	17	16	17	5	6	1	3	4	3	0	0.630	1.000	1.000
281	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(6), ATR(4), CDC25C(1), CHEK1(2), CHEK2(2)	3786185	15	10	15	8	9	2	1	2	1	0	0.965	1.000	1.000
282	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(5), CREBBP(5), EP300(11), FZD1(2), GSK3B(2), LDB1(1), LEF1(2), TRRAP(4)	8368674	33	26	33	9	15	3	5	5	5	0	0.452	1.000	1.000
283	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(1), GNAS(3), GNB1(2), NFKB1(3), NOS3(3), NR3C1(2), PIK3CA(2), PIK3R1(3), RELA(2)	4578907	21	18	21	9	6	4	5	3	3	0	0.911	1.000	1.000
284	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), GNAS(3), PLCE1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	3744348	11	8	11	8	5	1	1	2	2	0	0.991	1.000	1.000
285	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSD(2), ARSE(3), CYP11B1(2), HSD11B1(1), SRD5A1(1), STS(4), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2)	6881742	22	20	22	9	10	1	2	4	5	0	0.800	1.000	1.000
286	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(1), RELN(6), VLDLR(2)	3519876	10	9	9	6	6	0	3	0	1	0	0.941	1.000	1.000
287	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCKAP1(2), NTRK1(5), PIR(1), PSMA7(1), RAC1(1), WASF1(1), WASF2(1)	3856168	16	12	16	9	5	3	4	2	2	0	0.967	1.000	1.000
288	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BID(2), BIK(3), BIRC3(1), CASP9(2), DIABLO(1), ENDOG(1)	3424172	12	11	12	5	6	0	3	2	1	0	0.766	1.000	1.000
289	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), ANAPC2(2), ANAPC4(1), ANAPC5(4), BTRC(1), CDC16(1), CDC20(3), CDC27(7), CUL1(4), CUL2(2), CUL3(7), FBXW11(2), FBXW7(3), FZR1(4), RBX1(1), SKP1(1), SKP2(1), UBA1(4), UBE2C(1), VHL(2), WWP1(6), WWP2(3)	10201850	61	47	61	12	21	6	13	10	11	0	0.203	1.000	1.000
290	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(2), MAP3K1(7), NCOR2(8), RXRA(2), THRA(1), THRB(1)	4415302	23	15	22	9	17	1	1	1	3	0	0.656	1.000	1.000
291	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(3), CAD(5), CPS1(2), EPRS(4), GAD1(4), GAD2(2), GCLC(3), GFPT1(3), GLS(5), GLS2(1), GLUL(2), GMPS(1), GOT1(2), GOT2(2), GPT(2), GSS(1), NADSYN1(1), PPAT(2), QARS(1)	8384983	47	34	47	12	20	2	7	11	7	0	0.301	1.000	1.000
292	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	GLB1(1), LCT(5), SLC33A1(1), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(2), ST8SIA5(2)	4146724	14	11	14	7	7	0	4	1	2	0	0.848	1.000	1.000
293	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(2), APC(1), AXIN1(5), BTRC(1), DLL1(1), FZD1(2), GSK3B(2), NOTCH1(8), PSEN1(2)	5443793	24	21	24	8	11	3	6	2	2	0	0.559	1.000	1.000
294	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(2), LEP(2), LEPR(2), PRKAB1(1), PRKAG1(1), PRKAG2(3)	3636322	16	11	16	5	10	1	2	2	1	0	0.584	1.000	1.000
295	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(2), CSF1R(2), EGF(2), EGFR(2), PDGFRA(1), SH3GLB2(1), SH3KBP1(3), SRC(2)	4181671	15	12	15	9	7	2	2	2	2	0	0.950	1.000	1.000
296	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1)	5910906	23	19	23	8	7	2	9	1	4	0	0.698	1.000	1.000
297	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASDHPPT(1), AASS(2), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLST(1), DOT1L(6), EHHADH(2), EHMT1(3), EHMT2(7), HADHA(3), PLOD1(2), PLOD2(2), PLOD3(1), SHMT1(1), SHMT2(3)	9322414	51	36	51	12	20	6	13	8	4	0	0.167	1.000	1.000
298	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1)	5252646	17	14	17	6	10	1	2	1	3	0	0.769	1.000	1.000
299	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	DBH(1), DDC(3), GAD1(4), GAD2(2), HDC(2), MAOA(2), PAH(2), PNMT(1), SLC18A3(2), TPH1(2)	3672638	21	17	21	9	14	0	3	3	1	0	0.650	1.000	1.000
300	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(4), ABCG2(2), BCHE(2), CES1(1), CYP3A4(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2)	5732107	21	20	21	8	7	2	3	6	3	0	0.793	1.000	1.000
301	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(1), ASS1(4), CKB(2), CPS1(2), EPRS(4), GATM(3), GLUD2(11), GOT1(2), GOT2(2), LAP3(3), NOS1(4), NOS3(3), OAT(1), OTC(1), P4HA1(1), PARS2(1), PRODH(1), PYCR2(2), RARS(1), RARS2(3)	9133907	56	40	49	14	27	5	5	12	7	0	0.178	1.000	1.000
302	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(3), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(3), NR1D1(1), PER1(2), PER2(3), PER3(3)	4345115	18	16	18	9	7	0	6	3	2	0	0.913	1.000	1.000
303	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(2), ABCB11(5), ABCB4(4), ABCC1(4), ABCC3(3), GSTP1(2)	3620024	20	16	20	8	10	1	6	2	1	0	0.552	1.000	1.000
304	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCL4(1), CCR5(1), FOS(1), PLCG1(1), PTK2B(1)	3466374	5	4	5	7	2	0	1	1	1	0	0.998	1.000	1.000
305	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG7(1), BECN1(1), IFNA16(1), IFNA2(1), INS(3), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(4), ULK3(1)	5363163	17	16	17	8	10	1	2	2	2	0	0.910	1.000	1.000
306	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(1), DLD(3), DLST(1), FH(2), IDH2(4), IDH3B(3), MDH1(1), OGDH(7), PC(6), PDHX(1), PDK3(3), PDK4(1), SDHA(4), SDHB(2), SDHD(2), SUCLA2(1), SUCLG2(1)	7198270	46	30	46	12	17	3	7	5	13	1	0.362	1.000	1.000
307	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(1), AGT(3), AGTR2(1), ANPEP(5), CTSA(3), ENPEP(2), LNPEP(1), MME(2), NLN(2), THOP1(2)	5333009	27	19	27	9	15	2	4	5	1	0	0.474	1.000	1.000
308	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), BST1(2), CD38(1), ENPP1(6), ENPP3(1), NADK(2), NADSYN1(1), NMNAT2(1), NNT(2), NT5C1A(1), NT5C1B(1), NT5C2(1)	5435046	20	13	19	7	8	1	3	5	3	0	0.639	1.000	1.000
309	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(2), RPE(2), UCHL1(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2)	4421983	13	13	13	5	4	3	1	4	1	0	0.811	1.000	1.000
310	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(1), DARS(3), EPRS(4), GARS(1), IARS(1), KARS(2), LARS(4), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(1)	8051628	26	20	26	8	12	0	4	5	5	0	0.665	1.000	1.000
311	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), FDXR(2), SHMT1(1)	4047315	19	16	19	7	8	5	3	2	1	0	0.644	1.000	1.000
312	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT2(2), FUT4(2), FUT6(1), FUT7(1)	4065392	10	9	10	5	5	1	1	2	1	0	0.825	1.000	1.000
313	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(2), CA1(1), CA13(2), CA5A(1), CA5B(1), CA6(1), CA7(2), CA8(1), CA9(2), CPS1(2), CTH(2), GLS(5), GLS2(1), GLUD2(11), GLUL(2)	5347059	37	32	31	10	15	2	3	11	6	0	0.458	1.000	1.000
314	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GABBR1(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM2(5), GRM3(1), GRM4(6), GRM5(1)	5275415	20	18	20	8	10	0	6	2	2	0	0.488	1.000	1.000
315	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(2), GFPT1(3), GNE(1), HK1(1), HK2(2), PGM3(1), RENBP(2), UAP1(2)	4296535	15	11	15	6	9	2	1	2	1	0	0.724	1.000	1.000
316	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2B(1), CAMK4(1), ESRRA(1), HDAC5(3), MEF2A(2), PPP3CA(3), PPP3CB(1), SLC2A4(1)	5217303	20	19	20	8	7	3	7	1	2	0	0.732	1.000	1.000
317	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(2), FUCA2(1), GLB1(1), LCT(5), MANBA(2), NEU1(1), NEU2(1), NEU4(2)	4221676	15	14	15	6	8	1	4	1	1	0	0.747	1.000	1.000
318	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1), MASP1(1), MASP2(1), MBL2(1)	5415883	18	13	18	5	10	2	2	4	0	0	0.477	1.000	1.000
319	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(3), AOC3(2), CES1(1), ESCO2(1), LIPA(3), PLA1A(1), PNPLA3(1), PPME1(1), PRDX6(2)	6379470	15	12	15	5	7	0	3	2	3	0	0.669	1.000	1.000
320	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(2), F2(1), F2R(1), F2RL3(1), GNA12(1), GNA13(2), GNB1(2), MAP3K7(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PPP1R12B(1), PTK2B(1)	6517230	21	18	21	7	9	3	3	4	1	1	0.739	1.000	1.000
321	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3G(1), ETV5(3), IL12RB1(3), IL12RB2(1), JAK2(3), TYK2(2)	4727718	14	9	13	9	8	2	1	2	1	0	0.976	1.000	1.000
322	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CALCRL(1), CD97(2), ELTD1(3), EMR2(2), GHRHR(1), GIPR(1), GLP1R(2), GLP2R(2), GPR64(2), LPHN1(3), LPHN2(2), LPHN3(2), VIPR2(1)	6852271	25	19	25	9	14	1	4	3	3	0	0.647	1.000	1.000
323	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLST(1), DOT1L(6), EHHADH(2), EHMT1(3), EHMT2(7), HADHA(3), HSD17B10(2), HSD17B4(1), NSD1(8), OGDH(7), OGDHL(3), PIPOX(3), PLOD1(2), PLOD2(2), PLOD3(1), RDH11(2), RDH13(1), SETD1A(4), SETDB1(5), SHMT1(1), SHMT2(3), SPCS1(1), SUV39H1(2), SUV39H2(1)	14664683	87	57	86	22	33	13	18	10	13	0	0.260	1.000	1.000
324	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(2), GNA12(1), GNA13(2), GNB1(2), PLCB1(2), PPP1R12B(1)	5206639	13	12	13	5	6	3	0	3	1	0	0.791	1.000	1.000
325	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), ACYP1(1), DHRS1(1), DHRS2(1), EHHADH(2), ESCO2(1), FN3K(1), HADHA(3), PNPLA3(1), YOD1(1)	6531271	13	11	13	8	6	0	3	2	2	0	0.968	1.000	1.000
326	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(7), ALOX15(2), ALOX5(3), CBR1(3), CYP4F2(1), CYP4F3(3), EPX(3), GGT1(2), LTA4H(1), MPO(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PRDX2(1), PRDX6(2), PTGES2(1), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2), TPO(1)	7107425	50	30	50	12	21	9	7	8	5	0	0.174	1.000	1.000
327	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(4), ESR1(1), ESR2(2), ESRRA(1), HNF4A(3), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(1), NR1I3(1), NR2C2(3), NR2E1(1), NR2F1(1), NR2F2(3), NR2F6(1), NR3C1(2), NR4A2(1), PGR(2), PPARD(1), RARG(2), RORA(2), RORC(3), RXRA(2), RXRB(2), RXRG(2), THRA(1), THRB(1), VDR(1)	10331266	48	32	47	12	27	4	6	6	5	0	0.201	1.000	1.000
328	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(7), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(3), CBR1(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP4A11(2), CYP4A22(1), CYP4F2(1), CYP4F3(3), EPHX2(2), GGT1(2), GPX1(1), GPX4(1), LTA4H(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PTGES2(1), PTGIS(3), PTGS1(1), PTGS2(2), TBXAS1(2)	9940888	58	34	58	12	28	8	13	4	5	0	0.0555	1.000	1.000
329	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDK2(1), CDT1(2), DIAPH2(2), MCM10(2), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), NACA(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), PRIM1(1), RFC1(2), RFC3(2), RFC4(1), RFC5(2), RPA1(1), RPA4(1), RPS27A(1), UBA52(2)	12832881	51	33	49	11	24	3	9	7	8	0	0.105	1.000	1.000
330	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACAA2(1), ACADL(4), ACADSB(1), ACADVL(3), ACOX1(3), ACOX3(6), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CPT1A(2), CPT1B(1), CPT2(1), CYP4A11(2), CYP4A22(1), EHHADH(2), HADHA(3), HADHB(1), HSD17B10(2), HSD17B4(1)	12371974	65	43	65	17	29	4	14	12	5	1	0.228	1.000	1.000
331	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACAA2(1), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOX1(1), BCKDHA(1), EHHADH(2), HADHA(3), HADHB(1), HIBADH(1), HMGCL(1), IVD(3), MCCC1(3), MCCC2(1), MUT(1), OXCT1(1), PCCA(2), PCCB(1)	9108636	47	32	47	13	22	1	7	11	5	1	0.375	1.000	1.000
332	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(1), CRKL(1), DOCK1(5), FOS(1), GAB1(2), HGF(1), HRAS(1), ITGA1(3), ITGB1(5), MAP2K2(1), MAP4K1(3), PAK1(1), PIK3CA(2), PIK3R1(3), PTEN(5), PTK2(1), PTK2B(1), PTPN11(2), PXN(1), RAF1(2), RASA1(2), SOS1(3), SRC(2), STAT3(1)	10557816	50	40	50	13	10	3	8	10	19	0	0.617	1.000	1.000
333	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CSK(1), CTLA4(2), DAG1(6), DTYMK(1), FBXW7(3), GRAP2(1), ITPKA(3), ITPKB(3), LAT(2), LCP2(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PLCG1(1), PTPRC(2), RAF1(2), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(3), SOS2(3), VAV1(1), ZAP70(2)	14239370	68	44	68	18	22	6	15	9	16	0	0.376	1.000	1.000
334	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(3), CAD(5), CPS1(2), EPRS(4), GAD1(4), GAD2(2), GCLC(3), GFPT1(3), GLS(5), GLS2(1), GLUD2(11), GLUL(2), GMPS(1), GOT1(2), GOT2(2), GPT(2), GSS(1), NADSYN1(1), NAGK(2), PPAT(2), QARS(1)	9987236	61	42	55	18	25	2	7	18	9	0	0.462	1.000	1.000
335	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC3(1), BRAF(2), CAPN2(5), CAV1(1), CAV2(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(4), COL11A2(7), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), CRKL(1), DIAPH1(5), DOCK1(5), EGF(2), EGFR(2), ERBB2(3), FARP2(3), FLNA(9), FLNB(7), FLNC(9), FLT1(2), FN1(7), GSK3B(2), HGF(1), HRAS(1), IBSP(1), IGF1R(4), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAV(2), ITGB1(5), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), KDR(4), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), MAPK10(2), MAPK9(2), MYL7(1), MYL9(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PARVA(2), PARVG(1), PDGFA(1), PDGFD(1), PDGFRA(1), PDGFRB(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP5K1C(3), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PRKCG(5), PTEN(5), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(3), RELN(6), RHOA(2), ROCK2(4), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SRC(2), THBS1(5), THBS2(5), THBS3(5), TLN1(10), TLN2(5), TNC(5), TNN(1), TNR(2), TNXB(13), VAV1(1), VAV2(1), VAV3(5), VEGFA(1), VTN(1), VWF(7), ZYX(1)	93670878	465	124	457	176	207	41	68	63	84	2	0.992	1.000	1.000
336	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(1), ACTN2(1), ACTN4(1), APC(1), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF12(6), ARHGEF4(4), ARHGEF6(5), ARPC2(1), BAIAP2(3), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(2), CD14(1), CDC42(1), CFL2(1), CHRM1(2), CHRM2(3), CHRM3(2), CRKL(1), CSK(1), CYFIP1(3), CYFIP2(2), DIAPH1(5), DIAPH2(2), DIAPH3(3), DOCK1(5), EGF(2), EGFR(2), EZR(1), F2(1), F2R(1), FGD1(1), FGD3(2), FGF1(3), FGF10(1), FGF12(1), FGF14(2), FGF16(1), FGF19(1), FGF21(3), FGF23(1), FGF3(3), FGF6(1), FGF8(1), FGFR1(5), FGFR2(3), FGFR3(6), FGFR4(3), FN1(7), GIT1(3), GNA12(1), GNA13(2), GNG12(1), GSN(2), HRAS(1), INS(3), IQGAP1(2), IQGAP2(6), IQGAP3(6), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(5), ITGB2(3), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(6), LIMK2(7), MAP2K2(1), MSN(3), MYH10(2), MYH14(7), MYH9(5), MYL7(1), MYL9(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PDGFA(1), PDGFRA(1), PDGFRB(3), PFN1(1), PFN3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(2), RHOA(2), ROCK2(4), RRAS(1), SCIN(6), SOS1(3), SOS2(3), SSH1(3), SSH2(6), SSH3(1), TIAM1(3), TIAM2(3), VAV1(1), VAV2(1), VAV3(5), WAS(2), WASF1(1), WASF2(1)	70664903	352	118	347	125	146	41	64	50	51	0	0.802	1.000	1.000
337	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY8(4), ADCY9(7), ADORA2A(3), ADRA1A(3), ADRA1B(1), ATP2A1(3), ATP2A2(1), ATP2A3(2), ATP2B1(2), ATP2B2(1), ATP2B3(6), ATP2B4(3), AVPR1B(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(2), CACNA1G(5), CACNA1H(5), CACNA1I(7), CACNA1S(6), CAMK2A(4), CAMK2B(1), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM1(2), CHRM2(3), CHRM3(2), EDNRB(3), EGFR(2), ERBB2(3), ERBB3(3), ERBB4(5), F2R(1), GNA11(1), GNA14(1), GNAS(3), GRIN2A(2), GRIN2C(1), GRIN2D(3), GRM5(1), GRPR(1), HRH2(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NOS1(4), NOS3(3), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX5(1), P2RX7(1), PDE1C(1), PDGFRA(1), PDGFRB(3), PHKA1(9), PHKA2(3), PHKB(3), PHKG1(1), PHKG2(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PTGFR(2), PTK2B(1), RYR1(12), RYR2(14), RYR3(16), SLC25A5(1), SLC8A1(5), SLC8A2(1), SLC8A3(3), SPHK1(2), TACR2(2), TBXA2R(1), TNNC1(1), VDAC1(1), VDAC2(1), VDAC3(1)	69127956	336	111	331	134	165	26	67	35	43	0	0.777	1.000	1.000
338	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADRA1A(3), ADRA1B(1), ANXA6(2), ARRB1(5), ARRB2(2), ATP1A4(1), ATP1B1(5), ATP2A2(1), ATP2A3(2), ATP2B1(2), ATP2B2(1), ATP2B3(6), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1S(6), CACNB1(2), CACNB3(1), CALR(1), CAMK1(2), CAMK2A(4), CAMK2B(1), CAMK4(1), CASQ1(2), CHRM1(2), CHRM2(3), CHRM3(2), GJB4(2), GJB5(2), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(2), GNB1(2), GNG12(1), GRK4(1), GRK5(6), ITPR1(9), ITPR2(6), ITPR3(4), KCNB1(2), KCNJ3(2), MIB1(1), NME7(1), PKIB(2), PLCB3(3), PRKACA(2), PRKACB(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), PRKD1(3), RGS1(1), RGS10(1), RGS11(1), RGS14(2), RGS16(1), RGS19(2), RGS2(1), RGS20(3), RGS3(2), RGS6(2), RGS7(1), RGS9(5), RYR1(12), RYR2(14), RYR3(16), SFN(1), SLC8A1(5), SLC8A3(3), USP5(2)	48014640	272	110	268	108	129	22	51	28	42	0	0.803	1.000	1.000
339	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	AKT1(1), AKT2(3), AKT3(1), ARRB1(5), ARRB2(2), ATF2(1), BDNF(3), BRAF(2), CACNA1A(10), CACNA1B(7), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(2), CACNA1G(5), CACNA1H(5), CACNA1I(7), CACNA1S(6), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNA2D4(2), CACNB1(2), CACNB3(1), CACNB4(1), CACNG2(2), CACNG4(3), CACNG8(1), CD14(1), CDC42(1), CHUK(3), CRKL(1), DAXX(2), DUSP16(1), DUSP4(3), DUSP6(3), ECSIT(1), EGF(2), EGFR(2), ELK4(1), FASLG(2), FGF1(3), FGF10(1), FGF12(1), FGF14(2), FGF16(1), FGF19(1), FGF21(3), FGF23(1), FGF3(3), FGF6(1), FGF8(1), FGFR1(5), FGFR2(3), FGFR3(6), FGFR4(3), FLNA(9), FLNB(7), FLNC(9), FOS(1), GADD45B(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(1), IKBKB(3), IL1B(1), IL1R1(1), IL1R2(3), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K12(1), MAP3K14(2), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP3K7(1), MAP3K8(1), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(7), MAPK10(2), MAPK12(2), MAPK7(3), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), MAPKAPK3(1), MAX(1), NF1(2), NFATC2(3), NFATC4(4), NFKB1(3), NFKB2(3), NLK(2), NRAS(1), NTF3(1), NTRK1(5), NTRK2(2), PAK1(1), PDGFA(1), PDGFRA(1), PDGFRB(3), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPP3CA(3), PPP3CB(1), PPP5C(2), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(4), RASA1(2), RASA2(2), RASGRF1(7), RASGRF2(2), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA6(3), RRAS(1), SOS1(3), SOS2(3), SRF(1), STK4(1), TAOK1(2), TAOK2(1), TAOK3(2), TGFB1(2), TGFBR1(1), TGFBR2(1), TNF(1), TRAF2(1), ZAK(2)	73277318	392	110	388	131	187	38	56	51	58	2	0.453	1.000	1.000
340	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CHAD(1), COL11A1(4), COL11A2(7), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), DAG1(6), FN1(7), FNDC1(4), FNDC3A(2), GP6(2), GP9(1), HSPG2(10), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAV(2), ITGB1(5), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), RELN(6), SDC2(1), SDC3(1), SDC4(1), SV2A(1), SV2B(2), SV2C(1), THBS1(5), THBS2(5), THBS3(5), TNC(5), TNN(1), TNR(2), TNXB(13), VTN(1), VWF(7)	57320200	303	99	300	123	141	29	45	34	52	2	0.997	1.000	1.000
341	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(5), ACACB(5), AKT1(1), AKT2(3), AKT3(1), ARAF(1), BAD(1), BRAF(2), CBL(2), CBLB(3), CBLC(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(9), FLOT1(1), FOXO1(3), G6PC2(1), GCK(2), GSK3B(2), GYS1(2), GYS2(2), HRAS(1), IKBKB(3), INPP5D(1), INS(3), INSR(3), IRS1(1), IRS2(2), KRAS(2), LIPE(2), MAP2K2(1), MAPK10(2), MAPK9(2), NRAS(1), PCK1(1), PCK2(1), PDE3B(3), PFKL(4), PFKP(3), PHKA1(9), PHKA2(3), PHKB(3), PHKG1(1), PHKG2(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PKLR(1), PPARGC1A(4), PPP1CA(2), PPP1CC(1), PPP1R3A(2), PRKAB1(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAG3(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCI(4), PRKX(3), PTPN1(2), PTPRF(5), PYGB(2), PYGL(2), PYGM(4), RAF1(2), RAPGEF1(3), RHEB(2), SH2B2(3), SHC1(1), SHC2(5), SHC4(2), SLC2A4(1), SORBS1(3), SOS1(3), SOS2(3), SREBF1(3), TRIP10(2), TSC1(3), TSC2(6)	40940348	205	97	202	77	80	14	48	35	28	0	0.800	1.000	1.000
342	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(1), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADM(1), ARRB1(5), ARRB2(2), ATF2(1), ATF3(1), ATF5(1), ATP2A2(1), ATP2A3(2), CACNB3(1), CAMK2A(4), CAMK2B(1), CORIN(1), CREB3(3), DGKZ(8), FOS(1), GABPA(1), GABPB2(1), GBA2(1), GNB1(2), GNG12(1), GRK4(1), GRK5(6), IGFBP1(1), IGFBP3(1), IGFBP4(2), IGFBP6(2), IL1B(1), ITPR1(9), ITPR2(6), ITPR3(4), MIB1(1), NFKB1(3), NOS1(4), NOS3(3), PDE4B(1), PDE4D(1), PKIB(2), PLCB3(3), PLCD1(5), PLCG1(1), PLCG2(4), PRKACA(2), PRKACB(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS10(1), RGS11(1), RGS14(2), RGS16(1), RGS19(2), RGS2(1), RGS20(3), RGS3(2), RGS6(2), RGS7(1), RGS9(5), RYR1(12), RYR2(14), RYR3(16), SFN(1), SLC8A1(5), TNXB(13), USP5(2)	44237865	237	97	235	89	113	20	44	22	38	0	0.701	1.000	1.000
343	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADORA1(2), ADORA2A(3), ADORA3(2), ADRA1A(3), ADRA1B(1), ADRA2B(2), ADRA2C(1), AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(1), CCKAR(2), CCKBR(2), CHRM1(2), CHRM2(3), CHRM3(2), CNR1(1), CNR2(1), DRD4(2), DRD5(3), EDNRB(3), F2(1), F2R(1), F2RL2(1), F2RL3(1), GABBR1(2), GABBR2(3), GABRA3(2), GABRA4(1), GABRB2(1), GABRB3(3), GABRD(1), GABRE(1), GABRG1(1), GABRG2(1), GABRG3(3), GABRP(2), GABRQ(2), GH2(1), GHRHR(1), GHSR(1), GIPR(1), GLP1R(2), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(2), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(2), GRIA2(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(2), GRIK3(2), GRIK4(1), GRIK5(3), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), GRIN3A(2), GRIN3B(2), GRM2(5), GRM3(1), GRM4(6), GRM5(1), GRPR(1), HCRTR2(4), HRH2(1), HRH3(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), LEP(2), LEPR(2), MC2R(1), MC4R(1), MCHR1(2), MLNR(1), NMUR2(3), NPBWR1(3), NPFFR1(1), NPFFR2(1), NPY1R(1), NPY2R(1), NR3C1(2), NTSR1(1), OPRD1(1), OPRL1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY6(2), PARD3(2), PRLR(1), PRSS3(3), PTGDR(2), PTGFR(2), PTGIR(1), RXFP2(2), SSTR1(2), SSTR3(2), SSTR4(2), TAAR9(1), TACR2(2), TBXA2R(1), THRA(1), THRB(1), TRPV1(4), UTS2R(2), VIPR2(1)	56037872	218	96	217	86	93	22	52	39	12	0	0.527	1.000	1.000
344	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), CHAD(1), COL11A1(4), COL11A2(7), COL17A1(2), COL1A1(9), COL1A2(3), COL2A1(5), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(10), COL4A6(6), COL5A1(7), COL5A2(5), COL5A3(7), COL6A1(4), COL6A2(3), COL6A3(10), COL6A6(7), DES(2), DSC2(3), DSC3(5), DSG2(1), DSG3(1), DSG4(3), FN1(7), GJA3(1), GJB4(2), GJB5(2), GJC1(2), GJC3(1), IBSP(1), ITGA6(3), ITGB4(5), KRT1(1), KRT10(1), KRT13(4), KRT16(1), KRT17(2), KRT18(1), KRT2(3), KRT20(1), KRT23(1), KRT27(2), KRT3(2), KRT32(1), KRT33A(1), KRT35(2), KRT36(2), KRT37(3), KRT38(1), KRT4(2), KRT40(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT71(1), KRT74(1), KRT75(1), KRT76(1), KRT77(4), KRT78(4), KRT79(1), KRT82(1), KRT83(1), KRT84(1), KRT85(3), KRT86(2), KRT9(3), LAMA1(5), LAMA2(8), LAMA3(10), LAMA4(4), LAMA5(9), LAMB1(7), LAMB2(4), LAMB3(6), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), LMNA(3), LMNB2(1), NES(1), PRPH(2), RELN(6), THBS1(5), THBS2(5), THBS3(5), TNC(5), TNN(1), TNR(2), TNXB(13), VIM(1), VTN(1), VWF(7)	63290651	320	95	316	127	144	27	53	41	53	2	0.990	1.000	1.000
345	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(3), ACVR2A(3), ACVR2B(2), AMH(2), AMHR2(3), BMP7(1), BMPR1A(1), BMPR1B(1), CCL15(1), CCL17(1), CCL27(1), CCL28(1), CCL4(1), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CCR9(1), CD27(3), CD40(1), CLCF1(2), CNTF(1), CNTFR(2), CRLF2(1), CSF1(1), CSF1R(2), CSF2RA(2), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL1(1), CXCL11(1), CXCL13(1), CXCL14(1), CXCL16(1), EDA(2), EDA2R(1), EGF(2), EGFR(2), EPOR(3), FASLG(2), FLT1(2), FLT4(5), GDF5(2), GH2(1), HGF(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), IL10(1), IL10RA(5), IL12RB1(3), IL12RB2(1), IL15RA(1), IL17RA(3), IL17RB(4), IL19(1), IL1B(1), IL1R1(1), IL1R2(3), IL21R(3), IL22RA1(4), IL26(1), IL2RA(1), IL2RB(3), IL2RG(1), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(5), INHBA(1), INHBB(1), KDR(4), KIT(1), LEP(2), LEPR(2), LIF(2), LIFR(4), LTA(1), LTBR(1), MPL(2), OSM(1), OSMR(1), PDGFRA(1), PDGFRB(3), PLEKHO2(1), PRLR(1), TGFB1(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFRSF6B(1), TNFSF10(3), TNFSF15(1), TNFSF8(2), TPO(1), VEGFA(1), XCL1(1), XCR1(1)	44242109	189	93	189	56	78	21	29	29	32	0	0.349	1.000	1.000
346	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(6), ABLIM1(3), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDC42(1), CDK5(1), CFL2(1), DCC(2), DPYSL2(1), EFNA1(2), EFNA2(1), EFNA3(2), EFNB2(1), EFNB3(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(1), EPHA6(3), EPHA7(2), EPHA8(4), EPHB1(5), EPHB4(2), EPHB6(2), FES(1), GNAI2(1), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(5), KRAS(2), L1CAM(1), LIMK1(6), LIMK2(7), LRRC4C(4), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NRAS(1), NRP1(1), NTN1(2), NTNG1(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PLXNA1(2), PLXNA2(11), PLXNA3(4), PLXNB1(8), PLXNB2(8), PLXNB3(4), PPP3CA(3), PPP3CB(1), PTK2(1), RAC1(1), RAC2(1), RASA1(2), RGS3(2), RHOA(2), ROBO1(7), ROBO2(3), ROBO3(3), ROCK2(4), SEMA3A(3), SEMA3C(2), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(1), SEMA4D(4), SEMA4F(3), SEMA4G(2), SEMA5A(3), SEMA5B(5), SEMA6A(1), SEMA6B(4), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(6), SLIT2(2), SLIT3(5), SRGAP1(5), SRGAP2(1), SRGAP3(1), UNC5A(3), UNC5B(3), UNC5C(1)	49414475	260	93	258	78	117	26	39	39	39	0	0.181	1.000	1.000
347	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ADK(2), ADSL(2), ADSS(1), ADSSL1(2), AK2(1), AK5(1), AK7(2), ALLC(2), AMPD2(3), AMPD3(1), APRT(1), ATIC(1), DCK(1), DGUOK(1), ENPP1(6), ENPP3(1), ENTPD1(1), ENTPD5(4), ENTPD6(2), GART(3), GMPR(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HPRT1(1), IMPDH1(1), IMPDH2(1), NME1(1), NME7(1), NPR2(3), NT5C1A(1), NT5C1B(1), NT5C2(1), NUDT5(2), PAPSS2(4), PDE10A(2), PDE11A(4), PDE1C(1), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE5A(5), PDE6D(1), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(2), PFAS(4), PKLR(1), PNPT1(3), POLA1(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1), PPAT(2), PRIM1(1), PRIM2(3), PRPS1(1), PRPS2(3), PRUNE(2), RFC5(2), RRM1(3), XDH(2)	41508452	197	91	196	69	79	17	40	29	32	0	0.714	1.000	1.000
348	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(1), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CACYBP(1), CAMK2A(4), CAMK2B(1), CHD8(12), CREBBP(5), CSNK1A1(1), CSNK1E(3), CSNK2A1(5), CSNK2B(2), CTBP1(3), CTBP2(5), CUL1(4), DAAM1(1), DAAM2(1), DVL2(1), DVL3(3), EP300(11), FBXW11(2), FOSL1(1), FZD1(2), FZD10(1), FZD4(2), FZD5(2), FZD7(1), GSK3B(2), LEF1(2), LRP5(8), LRP6(9), MAP3K7(1), MAPK10(2), MAPK9(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NKD1(2), NKD2(4), NLK(2), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PORCN(1), PPARD(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP3CA(3), PPP3CB(1), PRICKLE1(2), PRICKLE2(3), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), PSEN1(2), RAC1(1), RAC2(1), RBX1(1), RHOA(2), ROCK2(4), RUVBL1(2), SFRP1(1), SFRP4(1), SFRP5(2), SKP1(1), SMAD2(2), SMAD4(2), TBL1X(3), TBL1XR1(3), TCF7(3), TCF7L1(2), VANGL1(3), VANGL2(1), WIF1(2), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2)	40732541	223	91	221	68	100	22	35	27	38	1	0.316	1.000	1.000
349	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(2), CADM3(2), CD2(1), CD22(2), CD34(1), CD4(2), CD40(1), CD58(1), CD6(2), CD86(3), CDH15(3), CDH2(1), CDH3(1), CDH4(1), CDH5(2), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CNTN1(5), CNTN2(3), CNTNAP1(3), CTLA4(2), ESAM(2), GLG1(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGB1(5), ITGB2(3), ITGB7(2), ITGB8(1), JAM2(2), L1CAM(1), MADCAM1(1), MPZL1(1), NCAM1(5), NCAM2(5), NEGR1(1), NEO1(6), NFASC(5), NLGN1(2), NLGN3(1), NRCAM(5), NRXN1(2), NRXN2(6), NRXN3(2), PDCD1(1), PDCD1LG2(3), PTPRC(2), PTPRF(5), PTPRM(7), PVRL1(3), PVRL2(1), PVRL3(2), SDC2(1), SDC3(1), SDC4(1), SELE(1), SELL(2), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(2), VCAN(12)	37421795	185	88	184	88	71	20	28	32	34	0	0.996	1.000	1.000
350	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), BCAR1(2), CAPN1(4), CAPN10(2), CAPN11(2), CAPN2(5), CAPN3(1), CAPN5(3), CAPN7(4), CAPN9(1), CAV1(1), CAV2(1), CAV3(1), CDC42(1), CSK(1), DOCK1(5), GIT2(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(5), ITGB2(3), ITGB3(3), ITGB4(5), ITGB5(6), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(2), MAPK12(2), MAPK4(1), MAPK6(1), MAPK7(3), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PIK3R2(3), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK2(4), SDCCAG8(2), SEPP1(2), SHC1(1), SORBS1(3), SOS1(3), SRC(2), TLN1(10), TNS1(9), VAV2(1), VAV3(5), ZYX(1)	34321586	180	87	175	69	70	19	34	27	30	0	0.873	1.000	1.000
351	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(5), ASH2L(2), CARM1(1), CTCFL(3), DOT1L(6), EED(2), EHMT1(3), EHMT2(7), EZH1(1), FBXO11(4), HCFC1(4), JMJD4(2), KDM6A(11), MEN1(2), MLL(4), MLL2(21), MLL3(18), MLL4(13), MLL5(5), NSD1(8), OGT(2), PAXIP1(6), PPP1CA(2), PPP1CC(1), PRDM2(4), PRDM7(1), PRDM9(2), PRMT5(2), PRMT6(1), PRMT7(3), RBBP5(2), SATB1(2), SETD1A(4), SETD2(17), SETDB1(5), SETDB2(2), SUV39H1(2), SUV39H2(1), SUV420H1(1), SUV420H2(1), SUZ12(2), WHSC1(1), WHSC1L1(2)	30736150	188	86	186	38	65	18	32	24	47	2	0.0664	1.000	1.000
352	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), AKT1(1), AKT2(3), AKT3(1), AMOTL1(4), ASH1L(5), CASK(2), CDC42(1), CDK4(1), CGN(5), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CRB3(1), CSDA(2), CSNK2A1(5), CSNK2B(2), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L1(5), EPB41L3(4), EXOC4(3), GNAI2(1), GNAI3(1), HRAS(1), INADL(7), JAM2(2), KRAS(2), LLGL1(1), LLGL2(2), MAGI1(3), MAGI2(3), MAGI3(2), MLLT4(5), MPDZ(2), MYH1(1), MYH10(2), MYH11(3), MYH13(4), MYH14(7), MYH15(3), MYH2(1), MYH3(1), MYH4(5), MYH6(8), MYH7(6), MYH7B(1), MYH8(1), MYH9(5), MYL7(1), MYL9(1), NRAS(1), PARD3(2), PARD6B(4), PPM1J(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP2R3A(1), PPP2R3B(1), PPP2R4(2), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PTEN(5), RAB13(1), RAB3B(2), RHOA(2), RRAS(1), SPTAN1(6), SRC(2), SYMPK(2), TJAP1(4), TJP1(5), TJP2(3), YES1(1), ZAK(2)	48918163	220	86	217	86	88	13	31	44	44	0	0.960	1.000	1.000
353	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(3), AKT3(1), CBL(2), CBLB(3), CBLC(1), CISH(2), CLCF1(2), CNTF(1), CNTFR(2), CREBBP(5), CRLF2(1), CSF2RA(2), CSF2RB(2), CSF3R(1), EP300(11), EPOR(3), GH2(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), IL10(1), IL10RA(5), IL12RB1(3), IL12RB2(1), IL13RA2(1), IL15RA(1), IL19(1), IL21R(3), IL22RA1(4), IL26(1), IL2RA(1), IL2RB(3), IL2RG(1), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(5), IRF9(2), JAK1(4), JAK2(3), JAK3(4), LEP(2), LEPR(2), LIF(2), LIFR(4), MPL(2), OSM(1), OSMR(1), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PRLR(1), PTPN11(2), SOCS5(1), SOCS7(2), SOS1(3), SOS2(3), SPRED2(1), SPRY2(1), SPRY4(2), STAM(2), STAM2(1), STAT1(2), STAT3(1), STAT5A(3), STAT5B(2), STAT6(4), TPO(1), TYK2(2)	36782523	173	83	172	48	73	19	29	23	29	0	0.418	1.000	1.000
354	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(3), AKT1(1), AURKB(1), BMPR1A(1), BUB1(1), CDIPT(1), CDKL2(3), CDS2(2), CLK1(2), CLK4(2), COL4A3BP(1), CSNK2A1(5), CSNK2B(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), INPP4A(3), INPP4B(4), INPPL1(3), ITPKA(3), ITPKB(3), MAP3K10(1), NEK1(1), NEK3(1), OCRL(5), PAK4(2), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3CA(2), PIK3CB(1), PIK3CG(2), PIM2(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCG1(1), PLCG2(4), PLK3(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), PRKD1(3), PRKG1(1), RAF1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), STK11(3), TGFBR1(1), VRK1(2)	28798772	159	80	157	61	67	13	29	19	31	0	0.920	1.000	1.000
355	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADK(2), ADSL(2), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD2(3), AMPD3(1), APRT(1), ATIC(1), ATP1B1(5), ATP5A1(1), ATP5B(2), ATP5F1(1), ATP5G2(1), ATP5J2(1), DCK(1), DGUOK(1), ENPP1(6), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HPRT1(1), IMPDH1(1), IMPDH2(1), NME1(1), NPR2(3), PAPSS2(4), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE5A(5), PDE6B(2), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(2), PFAS(4), PKLR(1), POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2), PPAT(2), PRPS1(1), PRPS2(3), PRUNE(2), RRM1(3)	32575425	161	79	160	54	57	13	29	30	32	0	0.702	1.000	1.000
356	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(6), ANAPC10(1), ANAPC2(2), ANAPC4(1), ANAPC5(4), ATM(6), ATR(4), BUB1(1), CCNA1(1), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(3), CDC25C(1), CDC27(7), CDC6(2), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), CREBBP(5), CUL1(4), E2F2(2), E2F3(2), EP300(11), ESPL1(6), FZR1(4), GADD45B(1), GADD45G(1), GSK3B(2), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), PKMYT1(1), PLK1(1), PRKDC(4), RBL1(2), RBL2(4), RBX1(1), SFN(1), SKP1(1), SKP2(1), SMAD2(2), SMAD4(2), SMC1A(6), SMC1B(3), TFDP1(1), TGFB1(2), WEE1(1), YWHAE(1)	34253250	151	77	150	46	68	14	26	22	21	0	0.533	1.000	1.000
357	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDIPT(1), CDS2(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), FN3K(1), INPP4A(3), INPP4B(4), INPP5B(2), INPP5D(1), INPP5E(1), INPPL1(3), ITPK1(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), OCRL(5), PI4KA(5), PI4KB(1), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PRKCG(5), PTEN(5), SYNJ1(4), SYNJ2(2)	31818401	159	76	157	56	71	15	23	22	28	0	0.749	1.000	1.000
358	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(2), ABCA12(10), ABCA13(15), ABCA2(2), ABCA3(4), ABCA4(10), ABCA5(4), ABCA6(4), ABCA7(8), ABCA8(5), ABCA9(1), ABCB1(2), ABCB10(2), ABCB11(5), ABCB4(4), ABCB5(1), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(5), ABCC1(4), ABCC10(9), ABCC11(6), ABCC12(3), ABCC2(4), ABCC3(3), ABCC4(4), ABCC5(6), ABCC6(4), ABCC9(4), ABCD2(3), ABCD3(1), ABCD4(2), ABCG1(1), ABCG2(2), ABCG4(2), ABCG5(3), ABCG8(1), CFTR(3), TAP1(3)	30073707	163	73	162	51	86	17	29	19	12	0	0.229	1.000	1.000
359	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), CACNA1C(9), CACNA1D(6), CACNA1F(2), CACNA1S(6), CAMK2A(4), CAMK2B(1), CDC42(1), EGFR(2), GNA11(1), GNAS(3), GNRHR(1), HBEGF(1), HRAS(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAP3K1(7), MAP3K2(1), MAP3K4(1), MAPK10(2), MAPK12(2), MAPK7(3), MAPK9(2), MMP14(1), NRAS(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLD1(2), PLD2(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCD(3), PRKX(3), PTK2B(1), RAF1(2), SOS1(3), SOS2(3), SRC(2)	32587332	165	73	161	63	75	17	33	13	27	0	0.738	1.000	1.000
360	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), ASIP(2), CAMK2A(4), CAMK2B(1), CREB3(3), CREB3L2(1), CREB3L3(1), CREB3L4(1), CREBBP(5), DCT(2), DVL2(1), DVL3(3), EDNRB(3), EP300(11), FZD1(2), FZD10(1), FZD4(2), FZD5(2), FZD7(1), GNAI2(1), GNAI3(1), GNAS(3), GSK3B(2), HRAS(1), KIT(1), KRAS(2), LEF1(2), MAP2K2(1), MITF(3), NRAS(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), POMC(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), RAF1(2), TCF7(3), TCF7L1(2), TYRP1(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2)	27703552	144	73	141	52	60	14	29	18	23	0	0.634	1.000	1.000
361	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2B(1), ASCC3(1), ATP13A2(4), DDX23(2), DDX4(3), DDX41(3), DDX47(3), DDX50(3), DDX51(2), DDX52(1), DDX54(2), DDX55(1), DDX56(3), DHX58(3), ENPP1(6), ENPP3(1), ENTPD7(6), EP400(6), ERCC2(5), ERCC3(3), G6PC2(1), GAA(2), GANC(2), GBA(1), GBA3(1), GBE1(3), GCK(2), GYS1(2), GYS2(2), HK1(1), HK2(2), IFIH1(3), MGAM(6), MOV10L1(2), NUDT5(2), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(4), RAD54B(3), RUVBL2(2), SETX(2), SI(4), SKIV2L2(2), SMARCA2(2), SMARCA5(3), TREH(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2)	31296198	143	72	143	52	63	12	19	33	16	0	0.846	1.000	1.000
362	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTG1(1), ACTN1(1), ACTN2(1), ACTN4(1), BAIAP2(3), CDC42(1), CREBBP(5), CSNK2A1(5), CSNK2B(2), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTNND1(4), EGFR(2), EP300(11), ERBB2(3), FARP2(3), FGFR1(5), IGF1R(4), INSR(3), IQGAP1(2), LEF1(2), LMO7(2), MAP3K7(1), MLLT4(5), NLK(2), PARD3(2), PTPN1(2), PTPRB(3), PTPRF(5), PTPRJ(6), PTPRM(7), PVRL1(3), PVRL2(1), PVRL3(2), RAC1(1), RAC2(1), RHOA(2), SMAD2(2), SMAD4(2), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(2), TCF7(3), TCF7L1(2), TGFBR1(1), TGFBR2(1), TJP1(5), WAS(2), WASF1(1), WASF2(1), YES1(1)	29447862	143	72	143	52	57	12	19	24	30	1	0.894	1.000	1.000
363	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), CSNK1D(1), EGF(2), EGFR(2), GNA11(1), GNAI2(1), GNAI3(1), GNAS(3), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HRAS(1), HTR2A(1), HTR2B(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), MAP2K5(3), MAP3K2(1), MAPK7(3), NPR2(3), NRAS(1), PDGFA(1), PDGFD(1), PDGFRA(1), PDGFRB(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKG1(1), PRKG2(3), PRKX(3), RAF1(2), SOS1(3), SOS2(3), SRC(2), TJP1(5), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1)	33558724	148	72	145	57	60	17	32	17	22	0	0.770	1.000	1.000
364	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(2), CACNA1A(10), GNA11(1), GNA12(1), GNA13(2), GNAI2(1), GNAI3(1), GNAS(3), GNAZ(2), GRIA1(2), GRIA2(2), GRID2(4), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(3), GUCY2D(4), GUCY2F(1), HRAS(1), IGF1R(4), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), LYN(1), MAP2K2(1), NOS1(4), NOS3(3), NPR2(3), NRAS(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCG(5), PRKG1(1), PRKG2(3), RAF1(2), RYR1(12)	28091372	135	72	134	39	51	15	27	24	18	0	0.234	1.000	1.000
365	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK3(2), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(2), CPSF3(3), CSTF2T(1), DDX1(1), DDX20(4), DHX16(3), DHX38(5), DHX8(1), DHX9(4), DICER1(3), FUS(3), GIPC1(1), LOC440563(1), METTL3(2), NONO(4), NXF1(2), PAPOLA(1), POLR2A(4), PRPF18(2), PRPF3(1), PRPF4(2), PRPF4B(4), PRPF8(6), PTBP1(1), RBM17(3), RBM5(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A3(1), SF3B1(9), SF3B2(6), SF3B4(5), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPE(1), SPOP(1), SRPK1(2), SRPK2(2), SRRM1(6), SUPT5H(4), U2AF2(2), XRN2(1)	26797666	128	70	124	33	52	9	26	19	22	0	0.354	1.000	1.000
366	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(4), MYBPC3(2), MYH3(1), MYH6(8), MYH7(6), MYH8(1), MYL1(1), MYL9(1), MYOM1(6), NEB(20), TCAP(1), TMOD1(2), TNNI3(1), TNNT1(2), TPM1(2), TPM4(1), TTN(63), VIM(1)	34644073	140	70	137	42	56	10	26	20	28	0	0.470	1.000	1.000
367	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BID(2), BRAF(2), CD244(1), CD48(1), FASLG(2), FCER1G(1), FCGR3A(2), HCST(1), HLA-A(1), HLA-B(2), HLA-C(1), HRAS(1), ICAM1(1), IFNA16(1), IFNA2(1), IFNAR1(2), IFNGR1(1), ITGAL(3), ITGB2(3), KIR2DL4(1), KIR3DL2(1), KLRC1(1), KLRC2(1), KLRC3(1), KRAS(2), LAT(2), LCP2(3), MAP2K2(1), MICA(1), MICB(1), NCR2(3), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NRAS(1), PAK1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PPP3CA(3), PPP3CB(1), PRF1(2), PRKCG(5), PTK2B(1), PTPN11(2), RAC1(1), RAC2(1), RAF1(2), SH2D1B(1), SH3BP2(4), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFSF10(3), TYROBP(2), ULBP1(3), VAV1(1), VAV2(1), VAV3(5), ZAP70(2)	28702061	142	69	139	43	53	11	21	27	30	0	0.637	1.000	1.000
368	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(2), ADORA2A(3), ADORA3(2), ADRA1A(3), ADRA1B(1), ADRA2C(1), AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCBP2(2), CCKAR(2), CCKBR(2), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CCR9(1), CCRL1(1), CCRL2(3), CHML(1), CHRM1(2), CHRM2(3), CHRM3(2), CNR1(1), CNR2(1), DRD4(2), DRD5(3), EDNRB(3), F2R(1), F2RL2(1), F2RL3(1), GHSR(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(2), GPR4(1), GPR50(1), GPR83(1), GPR85(1), GPR87(1), GRPR(1), HCRTR2(4), HRH2(1), HRH3(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1), MC4R(1), MLNR(1), NMUR2(3), NPY1R(1), NPY2R(1), NTSR1(1), OPRD1(1), OPRL1(1), OR10A5(1), OR11A1(1), OR12D3(1), OR1F1(1), OR5V1(1), P2RY1(2), P2RY2(1), P2RY6(2), PTGDR(2), PTGFR(2), PTGIR(1), RGR(1), SSTR1(2), SSTR3(2), SSTR4(2), SUCNR1(1), TBXA2R(1)	30597762	118	67	118	43	45	13	26	22	12	0	0.348	1.000	1.000
369	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(6), ABL2(2), AKT1(1), AKT2(3), AKT3(1), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(4), CAMK2B(1), CBL(2), CBLB(3), CBLC(1), CDKN1A(1), CRKL(1), EGF(2), EGFR(2), EIF4EBP1(1), ERBB2(3), ERBB3(3), ERBB4(5), EREG(1), GAB1(2), GSK3B(2), HBEGF(1), HRAS(1), KRAS(2), MAP2K2(1), MAP2K7(2), MAPK10(2), MAPK9(2), NCK2(2), NRAS(1), NRG1(4), NRG2(1), NRG3(4), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PRKCG(5), PTK2(1), RAF1(2), SHC1(1), SHC2(5), SHC4(2), SOS1(3), SOS2(3), SRC(2), STAT5A(3), STAT5B(2), TGFA(1)	26154850	132	67	130	42	49	9	29	26	19	0	0.553	1.000	1.000
370	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(1), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN11(1), CLDN16(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN5(1), CLDN7(1), CTNNA1(5), CTNNA2(2), CTNNA3(2), CTNND1(4), CYBB(2), ESAM(2), EZR(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(4), ITGB1(5), ITGB2(3), JAM2(2), MAPK12(2), MLLT4(5), MSN(3), MYL7(1), MYL9(1), NCF4(3), NOX1(2), NOX3(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PLCG2(4), PRKCG(5), PTK2(1), PTK2B(1), PTPN11(2), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RHOA(2), RHOH(2), ROCK2(4), SIPA1(2), TXK(1), VAV1(1), VAV2(1), VAV3(5), VCAM1(2)	31651055	133	66	131	49	53	9	22	24	25	0	0.802	1.000	1.000
371	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(6), ACTN1(1), ACTR2(1), ACTR3(1), AKT1(1), AKT2(3), AKT3(1), ARHGEF6(5), BCAR1(2), BRAF(2), CAV1(1), CDC42(1), CDKN2A(2), CSE1L(4), DOCK1(5), GRB7(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGA9(2), ITGB3BP(1), MAP2K7(2), MAP3K11(1), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), P4HB(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CB(1), PKLR(1), PLCG1(1), PLCG2(4), PTEN(5), PTK2(1), RAF1(2), ROCK2(4), SHC1(1), SOS1(3), SOS2(3), SRC(2), TLN1(10), TLN2(5), WAS(2), ZYX(1)	31131918	137	66	136	61	51	14	26	26	20	0	0.987	1.000	1.000
372	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(3), CBL(2), CBLB(3), CBLC(1), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(3), CTLA4(2), FOS(1), GRAP2(1), HRAS(1), ICOS(1), IKBKB(3), IL10(1), KRAS(2), LAT(2), LCP2(3), MALT1(2), MAP3K14(2), MAP3K8(1), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKB2(3), NFKBIA(2), NRAS(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PDCD1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKCQ(2), PTPRC(2), RASGRP1(2), RHOA(2), SOS1(3), SOS2(3), TNF(1), VAV1(1), VAV2(1), VAV3(5), ZAP70(2)	25680580	122	65	119	29	48	8	23	21	22	0	0.153	1.000	1.000
373	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(6), ADCY3(3), ADCY4(5), ADCY5(6), ADCY6(2), ADCY8(4), ADCY9(7), AKAP1(2), AKAP10(2), AKAP11(1), AKAP12(3), AKAP3(2), AKAP5(1), AKAP6(6), AKAP8(1), AKAP9(5), ARHGEF1(2), CHMP1B(1), GNA11(1), GNA12(1), GNA13(2), GNA14(1), GNAI2(1), GNAI3(1), GNAZ(2), GNB1(2), GNG12(1), HRAS(1), ITPR1(9), KCNJ3(2), KRAS(2), NRAS(1), PALM2(1), PDE1C(1), PDE4A(2), PDE4B(1), PDE4C(1), PDE4D(1), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(3), PPP3CA(3), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PRKD1(3), PRKD3(1), RHOA(2), RRAS(1), USP5(2)	29593464	136	64	134	48	60	8	26	17	25	0	0.651	1.000	1.000
374	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(4), ARAF(1), BRAF(2), CACNA1C(9), CAMK2A(4), CAMK2B(1), CAMK4(1), CREBBP(5), EP300(11), GRIA1(2), GRIA2(2), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), GRM5(1), HRAS(1), ITPR1(9), ITPR2(6), ITPR3(4), KRAS(2), MAP2K2(1), NRAS(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PPP1CA(2), PPP1CC(1), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKCG(5), PRKX(3), RAF1(2), RAPGEF3(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3)	25474461	124	62	122	50	54	9	26	19	16	0	0.896	1.000	1.000
375	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG10B(1), ALG12(1), ALG2(2), ALG3(1), ALG6(3), ALG9(2), B3GNT1(1), B3GNT6(3), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT5(1), B4GALT7(1), CHPF(2), CHST1(1), CHST11(1), CHST2(3), CHST3(1), CHST6(1), CHST7(1), DDOST(1), DPAGT1(2), EXT2(2), EXTL1(1), FUT11(2), GALNT10(2), GALNT11(2), GALNT14(2), GALNT2(5), GALNT3(1), GALNT4(1), GALNT5(2), GALNT6(3), GALNT7(1), GALNT9(1), GALNTL5(1), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST2(1), HS3ST3A1(1), HS6ST2(3), HS6ST3(1), MAN1B1(1), MAN1C1(3), MAN2A1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), MGAT5B(3), NDST1(3), NDST2(1), NDST3(2), NDST4(2), OGT(2), RPN1(1), RPN2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(4), XYLT1(2), XYLT2(2)	27972387	111	60	109	35	47	11	20	14	19	0	0.435	1.000	1.000
376	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR2A(3), ACVR2B(2), AMH(2), AMHR2(3), BMP4(1), BMP6(1), BMP7(1), BMP8A(2), BMP8B(2), BMPR1A(1), BMPR1B(1), CHRD(3), CREBBP(5), CUL1(4), E2F5(1), EP300(11), FST(3), GDF5(2), GDF7(1), ID1(1), INHBA(1), INHBB(1), LEFTY1(2), LTBP1(6), NODAL(2), NOG(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), RBL1(2), RBL2(4), RBX1(1), RHOA(2), ROCK2(4), SKP1(1), SMAD1(2), SMAD2(2), SMAD4(2), SMAD6(2), SMAD7(2), TFDP1(1), TGFB1(2), TGFBR1(1), TGFBR2(1), THBS1(5), THBS2(5), THBS3(5), TNF(1), ZFYVE9(2)	25069407	119	59	117	40	48	13	22	19	17	0	0.737	1.000	1.000
377	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(6), ATM(6), BUB1(1), CCNA1(1), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(3), CDC25C(1), CDC6(2), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), DTX4(3), E2F2(2), E2F3(2), E2F5(1), EP300(11), ESPL1(6), GSK3B(2), HDAC4(3), HDAC5(3), HDAC6(4), HDAC8(2), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), MPEG1(1), MPL(2), PLK1(1), PRKDC(4), PTPRA(1), RBL1(2), SKP2(1), SMAD4(2), TBC1D8(2), TFDP1(1), TGFB1(2), WEE1(1)	27762755	122	58	121	47	64	7	23	13	15	0	0.840	1.000	1.000
378	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), BDKRB2(1), C1QB(1), C1QC(1), C1R(2), C1S(1), C2(2), C3(3), C3AR1(2), C4BPB(1), C5(1), C5AR1(1), C6(2), C7(2), C8A(1), C8G(1), CD46(1), CD55(1), CD59(1), CFB(1), CFD(1), CFH(2), CFI(1), CPB2(1), CR1(1), CR2(4), F10(1), F12(5), F13A1(2), F13B(2), F2(1), F2R(1), F5(3), F7(2), F8(5), FGA(1), FGB(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(1), PLAUR(1), PLG(2), PROS1(2), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), TFPI(1), THBD(2), VWF(7)	22887242	92	57	92	35	37	8	19	19	9	0	0.911	1.000	1.000
379	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BAD(1), CABIN1(6), CAMK2B(1), CAMK4(1), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(5), CSNK2A1(5), CSNK2B(2), CTLA4(2), EP300(11), FCER1A(1), FCGR3A(2), FKBP1B(1), FOS(1), FOSL1(1), GSK3A(1), GSK3B(2), HRAS(1), ICOS(1), IL10(1), IL1B(1), IL2RA(1), JUNB(2), MAP2K7(2), MAPK9(2), MEF2A(2), NCK2(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB2(3), NUP214(5), OPRD1(1), P2RX7(1), PAK1(1), PIN1(1), PPIA(1), PPP3CB(1), PTPRC(2), RELA(2), SFN(1), TGFB1(2), TNF(1), TRAF2(1), TRPV6(3), VAV1(1), VAV2(1), VAV3(5), XPO5(1)	22875929	109	55	106	35	51	7	14	17	20	0	0.624	1.000	1.000
380	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(5), CDA(1), DCK(1), DPYD(4), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(4), ENTPD6(2), NME1(1), NME7(1), NT5C1A(1), NT5C1B(1), NT5C2(1), PNPT1(3), POLA1(5), POLA2(1), POLD1(4), POLD2(2), POLD4(1), POLR1A(1), POLR1B(2), POLR1C(1), POLR1D(1), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3A(3), POLR3B(3), POLR3GL(1), PRIM1(1), PRIM2(3), RFC5(2), RRM1(3), TK2(1), TXNRD1(2), TXNRD2(1), TYMS(1), UPRT(3)	20617968	84	54	84	37	31	9	17	10	17	0	0.976	1.000	1.000
381	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(3), ALPP(2), ALPPL2(1), ASCC3(1), ATP13A2(4), DDX23(2), DDX4(3), DDX41(3), DDX47(3), DDX50(3), DDX51(2), DDX52(1), DDX54(2), DDX55(1), DDX56(3), DHX58(3), ENTPD7(6), EP400(6), ERCC2(5), ERCC3(3), GCH1(1), IFIH1(3), MOV10L1(2), NUDT5(2), QDPR(1), RAD54B(3), RUVBL2(2), SETX(2), SKIV2L2(2), SMARCA2(2), SMARCA5(3)	15884759	83	54	83	26	39	6	14	17	7	0	0.412	1.000	1.000
382	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(5), CD14(1), CD19(5), CD1C(1), CD2(1), CD22(2), CD34(1), CD36(1), CD37(1), CD38(1), CD3G(1), CD4(2), CD5(1), CD55(1), CD59(1), CD7(1), CD9(1), CR1(1), CR2(4), CSF1(1), CSF1R(2), CSF2RA(2), CSF3R(1), EPOR(3), FCER2(1), FCGR1A(2), GP9(1), IL1B(1), IL1R1(1), IL1R2(3), IL2RA(1), IL4R(1), IL5RA(2), IL7R(1), IL9R(5), ITGA1(3), ITGA2(2), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(4), ITGB3(3), KIT(1), MME(2), TFRC(2), THPO(2), TNF(1), TPO(1)	20742074	91	54	91	34	40	10	13	12	16	0	0.863	1.000	1.000
383	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(1), AKT2(3), AKT3(1), APAF1(1), ATM(6), BAD(1), BID(2), BIRC3(1), CAPN1(4), CAPN2(5), CASP10(2), CASP9(2), CFLAR(1), CHUK(3), CSF2RB(2), ENDOG(1), FADD(1), FASLG(2), IKBKB(3), IL1B(1), IL1R1(1), IRAK4(1), MAP3K14(2), NFKB1(3), NFKB2(3), NFKBIA(2), NTRK1(5), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PPP3CA(3), PPP3CB(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10D(1), TNFSF10(3), TRADD(1), TRAF2(1)	21051912	97	53	96	38	39	8	17	17	16	0	0.927	1.000	1.000
384	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(1), AKT2(3), AKT3(1), CAMKK1(5), CAMKK2(2), CD36(1), CHUK(3), CPT1A(2), CPT1B(1), CPT2(1), G6PC2(1), IKBKB(3), IRS1(1), IRS2(2), JAK1(4), JAK2(3), JAK3(4), LEP(2), LEPR(2), MAPK10(2), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), PCK1(1), PCK2(1), POMC(1), PPARGC1A(4), PRKAB1(1), PRKAG1(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(2), RELA(2), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), SLC2A4(1), STAT3(1), STK11(3), TNF(1), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2)	21103362	104	53	102	39	45	9	19	12	19	0	0.689	1.000	1.000
385	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(3), AKT3(1), BAD(1), CDC42(1), CDK2(1), CDKN2A(2), CREB3(3), EBP(1), ERBB4(5), F2RL2(1), GAB1(2), GSK3A(1), GSK3B(2), IFI27(1), IGFBP1(1), INPPL1(3), IRS1(1), IRS2(2), NOLC1(2), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(7), PTEN(5), PTK2(1), PTPN1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SFN(1), SHC1(1), SLC2A4(1), SOS1(3), SOS2(3), TSC1(3), TSC2(6), YWHAE(1)	18802925	89	53	88	34	28	9	20	17	15	0	0.845	1.000	1.000
386	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AGK(1), AGPAT1(1), AGPAT3(2), AGPAT6(1), AKR1A1(4), AKR1B1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CEL(3), DAK(1), DGAT1(2), DGAT2(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GLA(1), GLB1(1), GPAM(2), LCT(5), LIPA(3), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(1), PNPLA3(1), PPAP2C(1)	14968351	80	52	79	34	36	7	13	13	11	0	0.881	1.000	1.000
387	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), INPP4A(3), INPP4B(4), INPP5B(2), INPP5E(1), INPPL1(3), ITPK1(1), ITPKA(3), ITPKB(3), MINPP1(2), MIOX(1), OCRL(5), PI4KA(5), PI4KB(1), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP4K2A(2), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCD3(1), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PTEN(5), SYNJ1(4), SYNJ2(2)	18872765	85	52	84	30	37	8	10	13	17	0	0.783	1.000	1.000
388	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(3), AKT3(1), FCER1A(1), FCER1G(1), GAB2(3), HRAS(1), INPP5D(1), KRAS(2), LAT(2), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAPK10(2), MAPK12(2), MAPK9(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCG1(1), PLCG2(4), PRKCD(3), PRKCE(2), RAC1(1), RAC2(1), RAF1(2), SOS1(3), SOS2(3), SYK(2), TNF(1), VAV1(1), VAV2(1), VAV3(5)	18222691	88	52	84	29	33	6	21	12	16	0	0.688	1.000	1.000
389	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(2), ATP4A(2), ATP5A1(1), ATP5B(2), ATP5F1(1), ATP5G2(1), ATP5J2(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), COX10(3), COX15(2), COX4I2(2), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB10(1), NDUFB11(1), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFB8(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS6(1), NDUFS7(3), NDUFV1(2), SDHA(4), SDHB(2), SDHD(2), TCIRG1(2), UQCRB(1), UQCRFS1(1)	14209228	74	51	73	25	27	6	12	17	12	0	0.666	1.000	1.000
390	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(3), AKT3(1), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(4), KRAS(2), MAP2K2(1), MAPK12(2), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NOS3(3), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCG1(1), PLCG2(4), PPP3CA(3), PPP3CB(1), PRKCG(5), PTGS2(2), PTK2(1), PXN(1), RAC1(1), RAC2(1), RAF1(2), SHC2(5), SPHK1(2), SRC(2), VEGFA(1)	18352659	96	51	95	26	39	6	17	17	17	0	0.281	1.000	1.000
391	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(3), AKT3(1), BCL10(1), BLNK(1), CARD11(3), CD19(5), CD22(2), CD81(1), CHUK(3), CR2(4), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(1), KRAS(2), LILRB3(1), LYN(1), MALT1(2), NFAT5(3), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKB2(3), NFKBIA(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), PLCG2(4), PPP3CA(3), PPP3CB(1), RAC1(1), RAC2(1), RASGRP3(1), SYK(2), VAV1(1), VAV2(1), VAV3(5)	18877267	99	51	96	30	43	7	15	17	17	0	0.513	1.000	1.000
392	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(5), ADCY6(2), ADCY8(4), CACNA1A(10), CACNA1B(7), GNAS(3), GNB1(2), GRM4(6), ITPR3(4), KCNB1(2), PLCB2(4), PRKACA(2), PRKACB(1), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), TAS1R1(2), TAS1R2(4), TAS1R3(1), TAS2R13(1), TAS2R14(2), TAS2R16(1), TAS2R39(1), TAS2R41(2), TAS2R43(1), TAS2R50(1), TRPM5(1)	14543637	77	51	76	31	37	3	19	6	12	0	0.607	1.000	1.000
393	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(1), BRAF(2), CEBPA(1), CHUK(3), DAXX(2), FOS(1), HRAS(1), IKBKB(3), MAP2K2(1), MAP2K3(2), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K12(1), MAP3K14(2), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP3K7(1), MAP3K8(1), MAP3K9(5), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(7), MAP4K5(2), MAPK10(2), MAPK12(2), MAPK4(1), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK3(1), MAX(1), MEF2A(2), NFKB1(3), NFKBIA(2), PAK1(1), RAC1(1), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), SHC1(1), STAT1(2), TGFB1(2), TGFBR1(1), TRADD(1), TRAF2(1)	24479092	110	51	107	45	51	10	11	17	20	1	0.948	1.000	1.000
394	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), ATM(6), ATR(4), BAI1(3), BBC3(1), BID(2), CASP9(2), CCNB1(1), CCNB2(1), CCNB3(2), CCNE1(2), CCNE2(1), CCNG1(1), CCNG2(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(2), GADD45B(1), GADD45G(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(1), PPM1D(2), PTEN(5), RCHY1(2), RFWD2(2), RPRM(1), SERPINB5(1), SERPINE1(1), SESN1(1), SESN2(1), SESN3(2), SFN(1), STEAP3(2), THBS1(5), TSC2(6), ZMAT3(2)	16355196	78	50	78	28	27	4	11	17	19	0	0.782	1.000	1.000
395	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(2), APH1A(1), CREBBP(5), CTBP1(3), CTBP2(5), DLL1(1), DLL4(3), DTX1(1), DTX2(1), DTX3L(1), DTX4(3), DVL2(1), DVL3(3), EP300(11), JAG1(5), JAG2(1), LFNG(2), MAML1(6), MAML2(5), MAML3(3), MFNG(1), NCOR2(8), NCSTN(2), NOTCH1(8), NOTCH2(7), NOTCH3(7), NOTCH4(2), NUMB(2), NUMBL(2), PSEN1(2), PSEN2(1), PTCRA(3), RBPJ(2), RBPJL(2)	17851412	112	50	110	59	56	15	14	8	18	1	0.999	1.000	1.000
396	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(3), AKT3(1), CCL4(1), CD14(1), CD40(1), CD86(3), CHUK(3), CXCL11(1), FADD(1), FOS(1), IFNA16(1), IFNA2(1), IFNAR1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK4(1), IRF5(2), IRF7(1), LBP(1), LY96(1), MAP2K2(1), MAP2K3(2), MAP2K7(2), MAP3K7(1), MAP3K8(1), MAPK10(2), MAPK12(2), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), RAC1(1), RELA(2), RIPK1(1), STAT1(2), TLR1(2), TLR2(2), TLR3(1), TLR4(3), TLR5(3), TLR6(1), TLR7(5), TNF(1), TOLLIP(1)	22655203	94	50	93	32	39	10	15	15	14	1	0.728	1.000	1.000
397	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(11), CDR1(2), FAU(2), IL6ST(3), PIGK(2), RPL10(2), RPL11(2), RPL13(1), RPL14(1), RPL18(2), RPL19(1), RPL21(2), RPL22(1), RPL24(1), RPL26(1), RPL29(1), RPL3(2), RPL3L(1), RPL6(1), RPL7A(3), RPL9(2), RPLP0(1), RPLP2(1), RPS10(1), RPS13(1), RPS14(1), RPS16(1), RPS2(1), RPS24(2), RPS27A(1), RPS3A(1), RPS4X(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3), RPS7(1), RPS8(2), RPSA(1), SLC36A2(1), TBC1D10C(2), UBA52(2)	13205426	77	50	73	28	31	10	9	14	13	0	0.810	1.000	1.000
398	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM17(2), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(2), GIT1(3), HBEGF(1), IKBKB(3), JAM2(2), LYN(1), MAP3K14(2), MAPK10(2), MAPK12(2), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(1), PLCG1(1), PLCG2(4), PTPN11(2), PTPRZ1(4), RAC1(1), RELA(2), SRC(2), TCIRG1(2), TJP1(5)	17099605	81	49	80	31	30	13	11	12	15	0	0.862	1.000	1.000
399	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AGPAT1(1), AGPAT3(2), AKR1A1(4), AKR1B1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GLA(1), GLB1(1), LCT(5), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(1), PPAP2C(1)	12310981	72	46	71	25	36	7	10	11	8	0	0.585	1.000	1.000
400	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(1), ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), G6PC2(1), GALM(3), GAPDH(2), GAPDHS(4), GCK(2), HK1(1), HK2(2), LDHAL6B(1), LDHB(1), PFKL(4), PFKP(3), PGAM2(1), PGK2(1), PGM1(2), PGM3(1), PKLR(1), TPI1(3)	14702458	72	46	71	30	34	7	10	9	11	1	0.859	1.000	1.000
401	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP6(1), BMP7(1), BMP8A(2), BMP8B(2), BTRC(1), CSNK1A1(1), CSNK1D(1), CSNK1E(3), FBXW11(2), GLI1(4), GLI2(1), GLI3(3), GSK3B(2), IHH(3), LRP2(9), PRKACA(2), PRKACB(1), PRKACG(1), PRKX(3), PTCH1(1), PTCH2(1), SHH(1), STK36(2), SUFU(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1), WNT8A(1), WNT8B(2), ZIC2(1)	15323518	65	46	64	36	30	7	15	4	9	0	0.993	1.000	1.000
402	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(3), AKT3(1), BAD(1), BCR(3), BLNK(1), CD19(5), CD22(2), CD81(1), CR2(4), CSK(1), DAG1(6), FLOT1(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(9), ITPR2(6), ITPR3(4), LYN(1), MAP4K1(3), NFATC1(1), NFATC2(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), PLCG2(4), PPP3CA(3), PPP3CB(1), PTPRC(2), RAF1(2), SHC1(1), SOS1(3), SOS2(3), SYK(2), VAV1(1)	18686805	89	46	89	36	39	6	12	16	16	0	0.909	1.000	1.000
403	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(3), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CELSR1(11), CELSR2(10), CELSR3(4), CHRM2(3), CHRM3(2), CIDEB(2), DRD4(2), EMR2(2), F2R(1), GHRHR(1), GNRHR(1), GPR116(3), GPR133(4), GPR135(4), GPR18(2), GPR55(1), GPR61(1), GPR84(2), GRPR(1), LGR6(2), LPHN2(2), LPHN3(2), NTSR1(1), PTGFR(2)	16831881	77	45	76	34	38	3	17	13	6	0	0.713	1.000	1.000
404	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(3), AKT3(1), BRAF(2), EIF4B(2), EIF4EBP1(1), HIF1A(2), INS(3), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(3), PIK3R2(3), PIK3R5(2), RHEB(2), RICTOR(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), RPS6KA6(3), STK11(3), TSC1(3), TSC2(6), ULK1(1), ULK2(4), ULK3(1), VEGFA(1)	13534326	64	45	63	28	23	4	18	11	7	1	0.940	1.000	1.000
405	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(3), AKT3(1), CAP1(2), CBL(2), CDC42(1), CDKN2A(2), F2RL2(1), FLOT1(1), GSK3A(1), GSK3B(2), IGFBP1(1), INPPL1(3), IRS1(1), IRS2(2), LNPEP(1), PARD3(2), PIK3CA(2), PIK3CD(1), PIK3R1(3), PTEN(5), PTPN1(2), RAF1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SERPINB6(1), SFN(1), SHC1(1), SLC2A4(1), SORBS1(3), SOS1(3), SOS2(3), YWHAE(1)	15000553	63	45	62	30	18	3	15	16	11	0	0.982	1.000	1.000
406	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(2), ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(4), ATP6V1H(1), ATP7A(1), ATP7B(7), COX10(3), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(3), NDUFB6(2), NDUFB7(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), SDHA(4), SDHB(2), SHMT1(1), UQCRB(1), UQCRFS1(1)	9661450	56	44	55	18	19	6	9	11	11	0	0.658	1.000	1.000
407	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(3), AKT3(1), ASAH1(1), BRAF(2), DAG1(6), EGFR(2), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), PI3(1), PIK3CB(1), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), RAF1(2), RGS20(3), SHC1(1), SOS1(3), SOS2(3), SRC(2), STAT3(1)	14820907	71	44	71	26	29	7	10	11	14	0	0.751	1.000	1.000
408	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(2), BIRC3(1), BIRC5(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), CHUK(3), FADD(1), FASLG(2), HELLS(2), IKBKB(3), IRF1(1), IRF2(1), IRF4(1), IRF5(2), IRF6(1), IRF7(1), LTA(1), MAP3K1(7), MAPK10(2), MDM2(1), NFKB1(3), NFKBIA(2), PLEKHG5(2), PRF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TRADD(1), TRAF1(2), TRAF2(1)	14358211	69	43	69	25	25	6	14	12	12	0	0.803	1.000	1.000
409	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(6), CCNA1(1), CCNB1(1), CCNE1(2), CCNE2(1), CCNG2(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), CREB3(3), CREB3L3(1), CREB3L4(1), E2F2(2), E2F3(2), E2F5(1), GBA2(1), MCM2(3), MCM3(2), MCM4(3), MCM5(2), MCM6(3), MCM7(2), MDM2(1), MYT1(7), NACA(5), POLA2(1), PRIM1(1), RBL1(2), RPA1(1), TFDP1(1), TNXB(13), WEE1(1)	19329985	77	43	75	25	47	3	12	9	6	0	0.354	1.000	1.000
410	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACMSD(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), AOX1(1), CARM1(1), CAT(2), CYP1B1(1), DDC(3), EHHADH(2), HAAO(3), HADHA(3), HEMK1(1), HSD17B10(2), HSD17B4(1), KYNU(1), LCMT1(1), LNX1(3), MAOA(2), MAOB(4), METTL2B(1), NFX1(3), OGDH(7), OGDHL(3), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), TPH1(2), TPH2(1), WBSCR22(1)	15319269	78	43	77	27	35	8	14	9	12	0	0.595	1.000	1.000
411	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), CD36(1), CITED2(1), CPT1B(1), CREBBP(5), EHHADH(2), EP300(11), HSD17B4(1), INS(3), LPL(1), ME1(1), MRPL11(2), NCOA1(1), NCOR1(4), NCOR2(8), NFKBIA(2), NR1H3(1), NR2F1(1), PDGFA(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTGS2(2), RELA(2), RXRA(2), STAT5A(3), STAT5B(2), TNF(1)	16014007	72	43	71	31	32	6	13	7	14	0	0.977	1.000	1.000
412	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(9), ITPR2(6), ITPR3(4), LIMK1(6), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PIK3CA(2), PIK3CD(1), PIK3CG(2), PIK3R1(3), PTEN(5), ROCK2(4), RPS4X(3), WASF1(1)	17786009	73	43	72	31	29	11	15	7	11	0	0.920	1.000	1.000
413	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), AXIN1(5), CSNK1E(3), DVL2(1), DVL3(3), FBXW2(1), FOSL1(1), FZD1(2), FZD10(1), FZD5(2), FZD7(1), GSK3B(2), LDLR(2), MAPK10(2), MAPK9(2), PLAU(1), PPP2R5C(3), PPP2R5E(1), PRKCD(3), PRKCE(2), PRKCG(5), PRKCI(4), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(1), TCF7(3), WNT10A(2), WNT10B(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(2), WNT5B(1)	15057867	69	43	68	24	28	8	14	6	13	0	0.559	1.000	1.000
414	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT3(2), AGPS(7), CDIPT(1), CDS2(2), CHKA(1), CHKB(1), CPT1B(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), GPD1(1), LCAT(2), LGALS13(1), PAFAH2(2), PCYT1A(2), PCYT1B(2), PEMT(3), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLCB2(4), PLCG1(1), PLCG2(4), PPAP2C(1)	12796164	72	42	72	23	30	12	10	7	13	0	0.470	1.000	1.000
415	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(4), ACADL(4), ACOX1(3), ACOX2(3), ACOX3(6), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), APOC3(1), AQP7(3), CD36(1), CPT1A(2), CPT1B(1), CPT2(1), CYP27A1(2), CYP4A11(2), CYP4A22(1), CYP7A1(2), EHHADH(2), FABP2(1), FABP3(1), FABP5(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(1), PCK2(1), PLTP(1), PPARD(1), RXRA(2), RXRB(2), RXRG(2), SCP2(3), SLC27A1(4), SLC27A4(2), SLC27A5(1), SLC27A6(2), SORBS1(3)	16514253	78	42	78	29	39	5	14	9	10	1	0.731	1.000	1.000
416	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(3), INPP4B(4), INPPL1(3), ITPKA(3), ITPKB(3), MIOX(1), OCRL(5), PIK3C2A(5), PIK3C2B(5), PIK3C2G(6), PIK3CA(2), PIK3CB(1), PIK3CG(2), PLCB1(2), PLCB2(4), PLCB3(3), PLCB4(2), PLCD1(5), PLCG1(1), PLCG2(4)	11383736	64	42	63	21	31	5	10	8	10	0	0.615	1.000	1.000
417	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6), F10(1), F12(5), F2(1), F2R(1), F5(3), F8(5), FGA(1), FGB(1), KLKB1(1), PROS1(2)	11278830	56	41	56	23	27	3	7	9	9	1	0.994	1.000	1.000
418	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CDA(1), DCK(1), DPYD(4), DPYS(4), DTYMK(1), ENTPD1(1), NME1(1), POLB(2), POLD1(4), POLD2(2), POLG(6), POLQ(8), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLRMT(2), RRM1(3), TK2(1), TXNRD1(2), TYMS(1)	14593639	62	41	62	21	19	8	10	9	16	0	0.797	1.000	1.000
419	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2B(1), ENPP1(6), ENPP3(1), GAA(2), GBA3(1), GBE1(3), GCK(2), GYS1(2), GYS2(2), HK1(1), HK2(2), MGAM(6), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(4), SI(4), UCHL1(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2)	14451683	56	41	56	28	18	8	8	12	10	0	0.989	1.000	1.000
420	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BID(2), BIRC3(1), CASP9(2), CFLAR(1), CHUK(3), DAXX(2), FADD(1), GSN(2), LMNA(3), LMNB2(1), MAP2K7(2), MAP3K1(7), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(3), NFKBIA(2), NUMA1(5), PRKCD(3), PRKDC(4), PSEN1(2), PSEN2(1), PTK2(1), RASA1(2), RELA(2), RIPK1(1), SPTAN1(6), TNF(1), TNFRSF1B(1), TRADD(1), TRAF1(2), TRAF2(1)	17642508	71	40	71	30	28	5	9	9	20	0	0.949	1.000	1.000
421	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(2), BAK1(1), BFAR(1), CAD(5), CASP10(2), CASP8AP2(6), CD7(1), CSNK1A1(1), DAXX(2), DEDD(1), DIABLO(1), EGFR(2), FADD(1), FAIM2(1), MAP2K7(2), MAP3K1(7), MAP3K5(1), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PFN1(1), PTPN13(7), RALBP1(4), RIPK1(1), SMPD1(3), TNFRSF6B(1), TPX2(1), TRAF2(1)	17695025	80	40	79	35	34	10	18	5	13	0	0.932	1.000	1.000
422	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(3), AOC3(2), ARG1(1), ARG2(1), CKB(2), CPS1(2), GATM(3), GOT1(2), GOT2(2), MAOA(2), MAOB(4), NOS1(4), NOS3(3), OAT(1), OTC(1), P4HA1(1), P4HB(2), RARS(1), SMS(1)	11230405	59	39	59	19	27	7	7	10	8	0	0.407	1.000	1.000
423	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1C1(1), AKR1C2(1), AKR1C3(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), CYP1B1(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2F1(1), CYP3A4(2), CYP3A43(2), CYP3A7(1), DHDH(4), EPHX1(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM4(1), GSTO2(1), GSTP1(2), GSTT1(2), MGST2(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2)	14532126	59	39	59	23	20	8	10	15	6	0	0.897	1.000	1.000
424	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(3), AKT3(1), BCR(3), CD19(5), CDKN2A(2), DAPP1(2), FLOT1(1), GAB1(2), ITPR1(9), ITPR2(6), ITPR3(4), LYN(1), PHF11(1), PIK3CA(2), PLCG2(4), PREX1(7), PTEN(5), PTPRC(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SYK(2), VAV1(1)	14026349	71	39	70	32	28	6	10	13	14	0	0.947	1.000	1.000
425	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(1), APC(1), ASAH1(1), BRAF(2), CAMP(1), CCL15(1), DAG1(6), EGFR(2), GNA11(1), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), MAPK10(2), PHKA2(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), RAF1(2), SRC(2)	13190298	58	39	58	21	22	7	7	10	12	0	0.781	1.000	1.000
426	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), BRAF(2), CAMP(1), CREB3(3), CREBBP(5), CRKL(1), DAG1(6), FRS2(1), MAP1B(5), MAP2K7(2), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), NTRK1(5), PIK3C2G(6), PIK3CA(2), PIK3CD(1), PIK3R1(3), PTPN11(2), RPS6KA3(2), SHC1(1), SRC(2)	13136733	64	39	62	32	25	8	13	9	9	0	0.975	1.000	1.000
427	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(3), AKT3(1), ARHGEF11(5), CDC42(1), DLG4(3), GNA13(2), LPA(6), MAP3K1(7), MAP3K5(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PHKA2(3), PI3(1), PIK3CB(1), PLD1(2), PLD2(1), PTK2(1), RDX(2), ROCK2(4), SRF(1), TBXA2R(1)	12397678	56	39	56	22	24	6	13	5	8	0	0.830	1.000	1.000
428	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACMSD(2), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), AOX1(1), CAT(2), CYP2A13(3), CYP2A6(3), CYP2A7(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(1), CYP2F1(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), CYP51A1(3), DDC(3), EHHADH(2), HAAO(3), HADHA(3), KYNU(1), MAOA(2), MAOB(4), TPH1(2)	13894167	64	39	63	19	31	4	15	8	6	0	0.329	1.000	1.000
429	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(3), AKT1(1), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(1), CREBBP(5), CSNK1A1(1), F2(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MYH2(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NKX2-5(4), PIK3CA(2), PIK3R1(3), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(2)	12776125	55	38	55	29	23	4	10	9	9	0	0.994	1.000	1.000
430	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(3), AKT3(1), BAD(1), BCR(3), BLNK(1), CD19(5), CSK(1), DAG1(6), ITPKA(3), ITPKB(3), LYN(1), MAP2K2(1), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PI3(1), PIK3CA(2), PIK3CD(1), PIK3R1(3), PLCG2(4), RAF1(2), SHC1(1), SOS1(3), SOS2(3), SYK(2), VAV1(1)	13368146	65	38	65	24	23	5	11	12	14	0	0.813	1.000	1.000
431	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), GAPDH(2), GCK(2), HK1(1), HK2(2), LDHB(1), PFKP(3), PGM1(2), PGM3(1), PKLR(1), TPI1(3)	12320866	55	37	54	26	25	5	8	9	7	1	0.941	1.000	1.000
432	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), AKR1A1(4), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(3), ALDOC(1), BPGM(1), DLD(3), GAPDH(2), GCK(2), HK1(1), HK2(2), LDHB(1), PFKP(3), PGM1(2), PGM3(1), PKLR(1), TPI1(3)	12320866	55	37	54	26	25	5	8	9	7	1	0.941	1.000	1.000
433	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(1), ALAS1(1), ALAS2(2), AMT(1), AOC2(3), AOC3(2), BHMT(6), CBS(1), CHDH(2), CHKA(1), CHKB(1), CTH(2), DLD(3), GARS(1), GATM(3), GCAT(1), GLDC(3), GNMT(1), MAOA(2), MAOB(4), PEMT(3), PIPOX(3), PISD(1), PSAT1(2), RDH11(2), RDH13(1), SARDH(3), SARS2(1), SHMT1(1), SHMT2(3), TARS2(3)	10894613	66	37	66	21	29	5	11	10	10	1	0.478	1.000	1.000
434	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), AOX1(1), CARM1(1), DBH(1), DCT(2), DDC(3), ECH1(1), ESCO2(1), GOT1(2), GOT2(2), HEMK1(1), HGD(1), HPD(3), LCMT1(1), MAOA(2), MAOB(4), METTL2B(1), PNMT(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), TPO(1), TYRP1(3), WBSCR22(1)	15020749	58	37	58	28	30	7	9	4	8	0	0.943	1.000	1.000
435	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT3(2), AGPAT6(1), CDIPT(1), CDS2(2), CHKA(1), CHKB(1), CHPT1(1), DGKA(1), DGKB(1), DGKD(3), DGKE(1), DGKG(4), DGKH(5), DGKQ(2), DGKZ(8), ESCO2(1), ETNK2(1), GPAM(2), GPD1(1), GPD1L(1), LCAT(2), PCYT1A(2), PCYT1B(2), PEMT(3), PISD(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLD1(2), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1)	16739032	69	37	69	26	34	9	7	6	13	0	0.728	1.000	1.000
436	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), EGFR(2), ERBB2(3), ERBB4(5), ETS1(1), ETV6(1), ETV7(1), FMN2(2), KRAS(2), NOTCH1(8), NOTCH2(7), NOTCH3(7), NOTCH4(2), PIWIL4(2), RAF1(2), SOS1(3), SOS2(3), SPIRE2(2)	13301717	55	37	54	26	20	3	11	8	13	0	0.976	1.000	1.000
437	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAA2(1), ACAD8(2), ACAD9(2), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(3), CYP27A1(2), CYP7A1(2), HADHB(1), LIPA(3), RDH11(2), RDH13(1), SLC27A5(1), SOAT2(1), SRD5A1(1)	8037393	47	36	47	18	24	2	7	8	6	0	0.737	1.000	1.000
438	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(3), ABAT(1), ACY3(3), ADSL(2), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(1), ASNS(2), ASS1(4), CAD(5), CRAT(2), DARS(3), DARS2(1), DDO(1), DLD(3), GAD1(4), GAD2(2), GOT1(2), GOT2(2), GPT(2), NARS(1), NARS2(1), PC(6)	9599061	58	36	57	19	23	3	9	9	13	1	0.625	1.000	1.000
439	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), BDKRB2(1), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(5), KDR(4), NOS3(3), PDE2A(3), PDE3B(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(3), RYR2(14), SLC7A1(4)	10409309	54	36	54	25	21	5	13	7	8	0	0.922	1.000	1.000
440	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(1), CDC42(1), DLD(3), DUSP4(3), GAB1(2), GCK(2), IL1R1(1), MAP2K5(3), MAP2K7(2), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K12(1), MAP3K2(1), MAP3K4(1), MAP3K5(1), MAP3K7(1), MAP3K9(5), MAPK10(2), MAPK7(3), MAPK9(2), MYEF2(1), NFATC3(3), NR2C2(3), PAPPA(4), SHC1(1), ZAK(2)	12508453	59	36	56	24	30	6	10	4	7	2	0.906	1.000	1.000
441	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(1), ACO2(3), CLYBL(1), CS(1), DLD(3), DLST(1), FH(2), IDH1(2), IDH2(4), IDH3B(3), MDH1(1), OGDH(7), OGDHL(3), PC(6), PCK1(1), PCK2(1), SDHA(4), SDHB(2), SDHD(2), SUCLA2(1), SUCLG2(1)	7533675	54	35	54	20	19	5	8	7	14	1	0.710	1.000	1.000
442	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(2), ARSE(3), CARM1(1), CYP11B1(2), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B7(1), LCMT1(1), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), SRD5A1(1), STS(4), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), WBSCR22(1)	12641463	47	35	47	20	21	4	2	9	11	0	0.916	1.000	1.000
443	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AMDHD1(2), AOC2(3), AOC3(2), CARM1(1), CNDP1(1), DDC(3), HDC(2), HEMK1(1), HNMT(1), LCMT1(1), MAOA(2), MAOB(4), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(1)	10069927	58	35	58	22	27	6	10	6	9	0	0.593	1.000	1.000
444	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(6), CTSB(1), CTSL1(2), CTSS(2), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(3), IFNA16(1), IFNA2(1), KIR2DL4(1), KIR3DL2(1), KIR3DL3(2), KLRC1(1), KLRC2(1), KLRC3(1), LTA(1), NFYA(2), NFYC(1), PDIA3(1), PSME2(2), RFX5(1), TAP1(3), TAPBP(2)	11715626	49	35	49	22	18	5	8	4	13	1	0.949	1.000	1.000
445	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), CHUK(3), DAXX(2), EGF(2), EGFR(2), ETS1(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), MAP2K3(2), MAP2K7(2), MAP3K1(7), MAP3K14(2), MAP3K5(1), NFKB1(3), NFKBIA(2), PRKCD(3), PRKCE(2), PRKCG(5), PRKCQ(2), RAF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TRAF2(1)	12367678	56	35	56	20	22	4	10	6	14	0	0.783	1.000	1.000
446	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAK1(1), BID(2), BIRC3(1), CASP9(2), FADD(1), FASLG(2), MAP3K1(7), MAP3K14(2), MAPK10(2), MCL1(1), MDM2(1), NFKB1(3), NFKBIA(2), PARP1(5), PRF1(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(1), TNFSF10(3), TRADD(1), TRAF1(2), TRAF2(1)	9253140	47	34	47	17	18	4	8	9	8	0	0.800	1.000	1.000
447	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CARM1(1), CREBBP(5), EP300(11), ERCC3(3), ESR1(1), GRIP1(4), GTF2A1(1), HDAC4(3), HDAC5(3), HDAC6(4), NCOR2(8), PELP1(2), POLR2A(4)	11840182	53	34	52	30	26	3	11	5	8	0	0.995	1.000	1.000
448	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), GNB1(2), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKBIA(2), PAK1(1), PIK3C2G(6), PLCB1(2), PPP3CA(3), PPP3CB(1), RAC1(1), RAF1(2), RELA(2)	9725733	50	34	50	15	21	6	6	7	10	0	0.621	1.000	1.000
449	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(1), ALAS1(1), ALAS2(2), AMT(1), AOC2(3), AOC3(2), BHMT(6), CBS(1), CHDH(2), CHKA(1), CHKB(1), CPT1B(1), CTH(2), DLD(3), GARS(1), GATM(3), GCAT(1), GLDC(3), MAOA(2), MAOB(4), PEMT(3), PISD(1), PLCB2(4), PLCG1(1), PLCG2(4), SARDH(3), SHMT1(1), SHMT2(3)	10715480	63	34	63	20	27	6	11	9	9	1	0.447	1.000	1.000
450	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(3), ALDOC(1), DLD(3), GAPDH(2), GAPDHS(4), GCK(2), GOT1(2), GOT2(2), HK1(1), HK2(2), LDHAL6B(1), LDHB(1), MDH1(1), PC(6), PCK1(1), PDHX(1), PFKL(4), PFKP(3), PGAM2(1), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(3)	10704617	47	34	47	25	16	4	6	5	15	1	0.983	1.000	1.000
451	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(2), ARSE(3), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(2), GAL3ST1(1), GALC(3), GBA(1), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU4(2), PPAP2C(1), SGMS1(2), SMPD1(3), SMPD2(2), SMPD3(2), SMPD4(4), SPHK1(2), SPTLC2(2)	9065745	46	34	46	15	16	3	12	6	9	0	0.583	1.000	1.000
452	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(5), ACSS1(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLD(3), LDHAL6B(1), LDHB(1), MDH1(1), ME1(1), ME2(1), ME3(3), PC(6), PCK1(1), PCK2(1), PKLR(1)	11804507	49	34	49	21	23	2	8	10	5	1	0.863	1.000	1.000
453	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(3), CARS(1), CARS2(1), DARS(3), DARS2(1), EPRS(4), FARSA(1), GARS(1), IARS(1), IARS2(1), KARS(2), LARS(4), LARS2(1), MARS(3), MARS2(1), NARS(1), NARS2(1), PARS2(1), QARS(1), RARS(1), RARS2(3), SARS2(1), TARS2(3), VARS(3), VARS2(5), YARS2(1)	13684415	51	34	51	17	21	3	9	11	7	0	0.682	1.000	1.000
454	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(1), BCAR1(2), BCR(3), CAPN1(4), CAV1(1), CRKL(1), CSK(1), HRAS(1), ITGA1(3), ITGB1(5), MAP2K2(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(2), SHC1(1), SOS1(3), SRC(2), TLN1(10), ZYX(1)	11983070	47	34	47	17	15	5	8	7	12	0	0.781	1.000	1.000
455	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(1), AKT2(3), AKT3(1), DAG1(6), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(1)	11423111	54	34	54	24	22	5	11	7	9	0	0.865	1.000	1.000
456	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3G(1), FOS(1), HRAS(1), LAT(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(3), PLCG1(1), PPP3CA(3), PPP3CB(1), PTPN7(1), RAC1(1), RAF1(2), RASA1(2), RELA(2), SHC1(1), SOS1(3), VAV1(1), ZAP70(2)	12057104	53	34	53	19	22	4	8	6	13	0	0.883	1.000	1.000
457	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(4), EEF1A2(1), EEF1B2(1), EEF1D(4), EEF1G(2), EEF2(4), EEF2K(5), EIF1AX(1), EIF2AK1(5), EIF2AK2(1), EIF2B5(1), EIF2S3(1), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(1), EIF4G3(7), EIF5(1), EIF5B(1), GSPT2(2), PABPC1(1), PABPC3(1), PAIP1(1)	11138501	49	34	49	29	16	1	14	6	11	1	0.999	1.000	1.000
458	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DPYD(4), DPYS(4), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), MLYCD(1), SMS(1)	7332556	48	33	48	18	22	2	8	8	7	1	0.707	1.000	1.000
459	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F12(5), F13B(2), F2(1), F5(3), F7(2), F8(5), FGA(1), FGB(1), LPA(6), PLAT(2), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(7)	8842574	42	33	42	17	20	2	7	7	6	0	0.913	1.000	1.000
460	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1R(4), INS(3), INSR(3), MAPK7(3), MEF2A(2), NFATC1(1), NFATC2(3), PIK3CA(2), PIK3R1(3), PPP3CA(3), PPP3CB(1)	8821872	41	33	40	15	15	7	10	4	5	0	0.778	1.000	1.000
461	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(5), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AMD1(2), AOC2(3), AOC3(2), ARG1(1), ARG2(1), ASS1(4), CPS1(2), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(1), SAT2(1), SMS(1)	7495150	49	33	48	18	21	5	6	8	9	0	0.626	1.000	1.000
462	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), AKT1(1), DAG1(6), DGKA(1), GCA(1), ITGA9(2), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NR1I3(1), PAK1(1), PDE3B(3), PI3(1), PIK3C2G(6), PIK3CA(2), PIK3CD(1), PIK3R1(3), RPS4X(3)	12387870	59	33	58	24	24	7	11	7	10	0	0.865	1.000	1.000
463	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(3), AKT3(1), ANKRD6(1), APC(1), AXIN1(5), AXIN2(1), CSNK1A1(1), DACT1(1), DKK3(1), GSK3A(1), GSK3B(2), LRP1(14), MVP(4), NKD1(2), NKD2(4), PIN1(1), PSEN1(2), PTPRA(1), SFRP1(1), WIF1(2)	10268679	50	33	49	21	28	6	7	4	5	0	0.738	1.000	1.000
464	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(5), GSN(2), HRAS(1), ITGA1(3), ITGB1(5), PFN1(1), PIK3CA(2), PIK3R1(3), PTK2(1), PXN(1), RAF1(2), SHC1(1), SRC(2), TLN1(10)	9447590	42	32	42	17	11	6	6	7	12	0	0.956	1.000	1.000
465	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	FCER1A(1), FCER1G(1), FOS(1), HRAS(1), LYN(1), MAP2K7(2), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PIK3CA(2), PIK3R1(3), PLA2G4A(3), PLCG1(1), PPP3CA(3), PPP3CB(1), RAF1(2), SHC1(1), SOS1(3), SYK(2), VAV1(1)	10821697	47	32	47	20	21	3	8	4	11	0	0.950	1.000	1.000
466	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(3), ALDOC(1), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), HK2(2), KHK(3), MTMR2(2), MTMR6(4), PFKFB1(1), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKL(4), PFKP(3), PHPT1(1), PMM1(1), RDH11(2), RDH13(1), TPI1(3), TSTA3(3)	9505641	44	32	43	26	18	4	7	7	8	0	0.989	1.000	1.000
467	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(3), AKT3(1), BAD(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(1), IRS2(2), JAK1(4), JAK3(4), MAP4K1(3), PIK3CA(2), PIK3CD(1), PIK3R1(3), RAF1(2), SHC1(1), SOS1(3), SOS2(3), STAT6(4)	9263506	43	32	43	14	13	2	11	8	9	0	0.597	1.000	1.000
468	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(1), ACTR2(1), ACTR3(1), AKT1(1), CDC42(1), CFL2(1), FLNA(9), FLNC(9), FSCN1(1), FSCN2(2), GDI1(1), LIMK1(6), MYH2(1), PAK1(1), PAK3(1), PAK4(2), PAK6(3), PAK7(1), PFN1(1), ROCK2(4), RPS4X(3), WASF1(1)	12180900	53	32	52	27	25	11	11	1	5	0	0.960	1.000	1.000
469	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(1), ASAH1(1), CAMP(1), CAV3(1), DAG1(6), DLG4(3), ITPR1(9), ITPR2(6), ITPR3(4), KCNJ3(2), RAC1(1), RYR1(12)	11671975	48	32	48	19	20	5	8	8	7	0	0.707	1.000	1.000
470	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(4), ACAA2(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOX1(1), BCKDHA(1), DBT(2), DLD(3), EHHADH(2), HADHA(3), HADHB(1), HIBADH(1), HIBCH(2), HMGCL(1), HSD17B10(2), HSD17B4(1), IVD(3), MCCC1(3), MCCC2(1), MUT(1), OXCT1(1), PCCA(2), PCCB(1)	10927643	51	31	51	16	24	3	6	12	5	1	0.529	1.000	1.000
471	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(1), CBS(1), CTH(2), GGT1(2), HEMK1(1), LCMT1(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS2(4), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), SCLY(3), SEPHS1(1), SEPHS2(2), WBSCR22(1)	6317303	40	31	40	13	16	3	6	6	9	0	0.577	1.000	1.000
472	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ABAT(1), ACSM1(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BDH2(1), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HMGCL(1), HSD17B10(2), HSD17B4(1), ILVBL(2), L2HGDH(2), OXCT1(1), PLA1A(1), PPME1(1), PRDX6(2), RDH11(2), RDH13(1)	10306880	44	31	44	19	22	2	5	11	4	0	0.867	1.000	1.000
473	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(2), BLVRB(1), COX10(3), COX15(2), CP(3), EPRS(4), FTMT(1), HMOX1(1), PPOX(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), UROD(1)	10608573	36	31	36	25	14	1	5	13	3	0	0.999	1.000	1.000
474	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(3), CASP1(1), GAPDH(2), INS(3), INSR(3), MAGI1(3), MAGI2(3), RERE(8), WWP1(6), WWP2(3)	6042301	37	31	37	11	16	3	7	5	6	0	0.633	1.000	1.000
475	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(1), LIMK1(6), MAP3K1(7), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLD1(2), PPP1R12B(1), RAC1(1), RALBP1(4), TRIO(7), VAV1(1), WASF1(1)	8830984	40	31	40	15	18	1	10	3	8	0	0.817	1.000	1.000
476	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(1), DAG1(6), ITPKA(3), ITPKB(3), ITPR1(9), ITPR2(6), ITPR3(4), NFAT5(3), PDE6A(2), PDE6B(2), PDE6C(1), PDE6D(1), SLC6A13(6)	9110888	51	31	51	20	23	3	8	9	8	0	0.717	1.000	1.000
477	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(1), CAPN1(4), ITGA1(3), ITGB1(5), ITGB3(3), PTK2(1), PXN(1), RAC1(1), SPTAN1(6), SRC(2), TLN1(10)	7240903	39	31	39	15	11	6	6	8	8	0	0.800	1.000	1.000
478	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6), P4HB(2), SLC23A1(2), SLC23A2(2), SLC2A1(1)	6435052	42	31	42	14	23	3	3	6	6	1	0.943	1.000	1.000
479	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(3), AGTR2(1), COL4A1(4), COL4A2(4), COL4A3(6), COL4A4(10), COL4A5(5), COL4A6(6)	6440800	40	30	40	12	22	3	3	6	5	1	0.889	1.000	1.000
480	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(2), ADSS(1), AGXT(2), AGXT2(1), ASNS(2), CAD(5), CRAT(2), DARS(3), DDO(1), GAD1(4), GAD2(2), GOT1(2), GOT2(2), GPT(2), NARS(1), PC(6)	6610283	41	30	41	13	15	3	7	6	10	0	0.572	1.000	1.000
481	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(4), CAPN2(5), EGF(2), EGFR(2), HRAS(1), ITGA1(3), ITGB1(5), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(10)	8331933	40	30	39	13	14	4	6	7	9	0	0.646	1.000	1.000
482	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(1), EIF4A2(2), EIF4B(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(7), PIK3CA(2), PIK3R1(3), PTEN(5), TSC1(3), TSC2(6)	7009055	35	30	35	11	6	1	12	6	10	0	0.703	1.000	1.000
483	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(5), ACADL(4), ACADSB(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3), LDHB(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG2(1)	8350081	39	30	39	13	17	1	7	10	3	1	0.598	1.000	1.000
484	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(1), AKT2(3), AKT3(1), BAD(1), CDKN2A(2), DAPP1(2), GSK3A(1), GSK3B(2), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(2), PTEN(5), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SFN(1), SHC1(1), SOS1(3), SOS2(3), YWHAE(1)	9083583	39	30	38	17	12	1	9	9	8	0	0.940	1.000	1.000
485	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(1), EGFR(2), IGF1R(4), POLR2A(4), TEP1(10), TERF1(3), TERT(8), TNKS(5), XRCC5(1)	6892906	38	30	38	14	16	3	11	1	7	0	0.587	1.000	1.000
486	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAD(1), CASP1(1), CASP10(2), CASP4(2), CASP9(2), CD40(1), DAXX(2), FADD(1), FASLG(2), IKBKE(3), LTA(1), MCL1(1), NFKB1(3), NFKBIA(2), NR3C1(2), NTRK1(5), PTPN13(7), RIPK1(1), TNF(1), TNFRSF1B(1), TRADD(1), TRAF1(2), TRAF2(1)	11047200	46	29	46	18	15	10	7	6	8	0	0.894	1.000	1.000
487	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BID(2), BIRC3(1), CASP10(2), CASP9(2), CFLAR(1), CHUK(3), FADD(1), GAS2(2), LMNA(3), MAP3K14(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(1), TNFRSF25(1), TNFSF10(3), TRADD(1), TRAF2(1)	8508673	41	29	41	17	14	4	5	9	9	0	0.886	1.000	1.000
488	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(2), BHMT(6), CBS(1), CTH(2), DNMT1(9), DNMT3A(7), DNMT3B(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(1), MTR(2)	5261445	42	29	42	13	16	2	10	6	8	0	0.594	1.000	1.000
489	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(1), FUCA1(2), FUCA2(1), GBA(1), GLB1(1), GNS(1), HGSNAT(6), HPSE(2), HPSE2(2), HYAL1(2), HYAL2(1), IDUA(5), LCT(5), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(4), NEU1(1), NEU2(1), NEU4(2), SPAM1(1)	8852782	45	29	42	19	22	2	8	10	3	0	0.824	1.000	1.000
490	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(1), RPL10A(1), RPL11(2), RPL13(1), RPL14(1), RPL18(2), RPL19(1), RPL21(2), RPL23A(1), RPL24(1), RPL26(1), RPL29(1), RPL3(2), RPL3L(1), RPL6(1), RPL9(2), RPS10(1), RPS13(1), RPS15A(1), RPS16(1), RPS2(1), RPS24(2), RPS3A(1), RPS7(1), RPS8(2), RPSA(1)	5672510	35	29	35	17	10	6	5	5	9	0	0.971	1.000	1.000
491	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), EDNRB(3), GHSR(1), GNRHR(1), GRPR(1), MC2R(1), MC4R(1), NPY1R(1), NPY2R(1), NTSR1(1), OPRD1(1), OPRL1(1), SSTR1(2), SSTR3(2), SSTR4(2), TACR2(2)	13102458	39	29	39	17	14	6	7	9	3	0	0.715	1.000	1.000
492	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ACYP1(1), AKR1B1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), DLD(3), LDHB(1), MDH1(1), ME1(1), ME2(1), ME3(3), PC(6), PCK1(1), PKLR(1)	9326720	40	29	40	18	17	2	7	9	4	1	0.905	1.000	1.000
493	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP1(1), ARHGAP5(3), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC2(1), BAIAP2(3), DIAPH1(5), GSN(2), LIMK1(6), PFN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), SRC(2), TLN1(10)	11626616	49	29	49	21	21	7	6	6	9	0	0.896	1.000	1.000
494	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ACAA2(1), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(3), CYP27A1(2), CYP7A1(2), HADHB(1), SOAT2(1), SRD5A1(1)	5862123	38	28	38	12	21	2	5	6	4	0	0.527	1.000	1.000
495	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(1), CBX3(1), CLDN5(1), CLOCK(3), CRY1(1), CRY2(1), EIF4G2(1), ETV6(1), G0S2(1), GFRA1(1), GSTP1(2), HERPUD1(2), HSPA8(2), NCKAP1(2), NCOA4(2), NR1D2(1), PER1(2), PER2(3), PIGF(1), PPP2CB(1), SF3A3(1), TOB1(3), UCP3(1), ZFR(1)	9283297	36	28	36	11	12	1	7	12	4	0	0.597	1.000	1.000
496	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(3), CS(1), DLD(3), DLST(1), FH(2), IDH1(2), IDH2(4), IDH3B(3), MDH1(1), PC(6), PCK1(1), SDHA(4), SDHB(2), SUCLA2(1), SUCLG2(1)	5204265	36	28	36	12	12	1	6	5	11	1	0.589	1.000	1.000
497	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), EGF(2), EGFR(2), FOS(1), HRAS(1), JAK1(4), MAP3K1(7), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(3)	9453367	43	28	43	13	16	0	7	7	13	0	0.675	1.000	1.000
498	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(6), ATR(4), BRCA1(3), CCNB1(1), CDC25C(1), CDKN1A(1), CHEK1(2), CHEK2(2), EP300(11), MDM2(1), MYT1(7), PRKDC(4), RPS6KA1(2), WEE1(1)	10459233	46	28	46	23	25	4	5	6	6	0	0.992	1.000	1.000
499	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DDC(3), HDC(2), HNMT(1), MAOA(2), MAOB(4), PRPS1(1), PRPS2(3)	6180921	40	28	40	13	21	4	8	5	2	0	0.343	1.000	1.000
500	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT1(1), B4GALT2(1), G6PC2(1), GAA(2), GALE(4), GANC(2), GCK(2), GLA(1), GLB1(1), HK1(1), HK2(2), LCT(5), MGAM(6), PFKL(4), PFKP(3), PGM1(2), PGM3(1), RDH11(2), RDH13(1)	9829079	43	28	43	26	23	3	7	2	8	0	0.992	1.000	1.000
501	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), AOC2(3), AOC3(2), CNDP1(1), DPYD(4), DPYS(4), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HIBCH(2), MLYCD(1), SMS(1)	6824485	43	28	43	17	21	2	6	7	7	0	0.744	1.000	1.000
502	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(5), ACACB(5), ACSS1(3), ACSS2(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), HADHA(3), HIBCH(2), LDHAL6B(1), LDHB(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG2(1)	10017791	44	28	44	15	24	1	6	9	4	0	0.545	1.000	1.000
503	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2B(3), GTF2I(1), GTF2IRD1(2), STON1(1), TAF1(5), TAF10(1), TAF1L(2), TAF2(1), TAF4(2), TAF4B(4), TAF5(1), TAF5L(3), TAF6(1), TAF7(2), TAF9B(1), TBPL2(1)	9123344	32	28	32	13	10	1	8	9	4	0	0.844	1.000	1.000
504	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(3), AKT3(1), CISH(2), IARS(1), IL2RG(1), IL4R(1), INPP5D(1), JAK1(4), JAK2(3), JAK3(4), PI3(1), PIK3CA(2), SHC1(1), SOS1(3), SOS2(3), SRC(2), STAT6(4), TYK2(2)	9333504	40	28	39	13	17	5	8	3	7	0	0.608	1.000	1.000
505	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(3), FOS(1), IKBKB(3), LY96(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), TLR10(2), TLR2(2), TLR3(1), TLR4(3), TLR6(1), TLR7(5), TOLLIP(1)	9216960	43	28	43	17	20	8	3	5	6	1	0.842	1.000	1.000
506	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), AKT1(1), ASAH1(1), GNB1(2), ITGAV(2), ITGB3(3), PDGFA(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLCB1(2), PTK2(1), RAC1(1), SMPD1(3), SMPD2(2), SPHK1(2), SRC(2)	6902983	30	27	30	12	9	3	11	4	3	0	0.885	1.000	1.000
507	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(1), ARSD(2), ARSE(3), ASAH1(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(1), NEU4(2), PPAP2C(1), SMPD1(3), SMPD2(2), SPTLC2(2)	6126713	33	27	33	11	12	3	7	4	7	0	0.711	1.000	1.000
508	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT6(1), FUT2(2), FUT4(2), FUT6(1), FUT7(1), GBGT1(1), PIGB(2), PIGF(1), PIGK(2), PIGL(1), PIGN(3), PIGO(2), PIGQ(3), PIGS(1), PIGU(1), PIGX(1), ST3GAL3(2), ST3GAL4(3), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(2), ST8SIA5(2)	12350622	41	27	41	17	22	2	7	5	5	0	0.691	1.000	1.000
509	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTG1(1), ARHGEF2(1), CD14(1), CDC42(1), CTTN(2), EZR(1), ITGB1(5), KRT18(1), LY96(1), NCK2(2), RHOA(2), ROCK2(4), TLR4(3), TLR5(3), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1), WAS(2)	12998409	43	27	43	19	20	4	7	6	6	0	0.823	1.000	1.000
510	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTG1(1), ARHGEF2(1), CD14(1), CDC42(1), CTTN(2), EZR(1), ITGB1(5), KRT18(1), LY96(1), NCK2(2), RHOA(2), ROCK2(4), TLR4(3), TLR5(3), TUBA4A(2), TUBB(2), TUBB1(1), TUBB2A(1), TUBB8(1), WAS(2)	12998409	43	27	43	19	20	4	7	6	6	0	0.823	1.000	1.000
511	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BAD(1), CBL(2), CFLAR(1), CRKL(1), FOS(1), HRAS(1), IL2RA(1), IL2RB(3), IL2RG(1), IRS1(1), JAK1(4), JAK3(4), NMI(1), PIK3CA(2), PIK3R1(3), PPIA(1), RAF1(2), SHC1(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2)	9162117	42	27	42	13	18	1	8	5	10	0	0.546	1.000	1.000
512	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), FOS(1), HRAS(1), JAK1(4), MAP3K1(7), PDGFA(1), PDGFRA(1), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(3)	8814454	41	27	41	13	15	0	8	6	12	0	0.716	1.000	1.000
513	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	FADD(1), LMNA(3), LMNB2(1), MADD(6), MAP3K1(7), MAP3K7(1), PAK1(1), PRKDC(4), RIPK1(1), SPTAN1(6), TNF(1), TRADD(1), TRAF2(1)	9920473	34	27	34	25	14	2	3	5	9	1	1.000	1.000	1.000
514	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(3), EIF2B5(1), EIF2S3(1), ELAVL1(1), FLT1(2), FLT4(5), HIF1A(2), HRAS(1), KDR(4), NOS3(3), PIK3CA(2), PIK3R1(3), PLCG1(1), PTK2(1), PXN(1), SHC1(1), VHL(2)	8664677	34	27	34	16	10	1	8	4	10	1	0.965	1.000	1.000
515	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(1), ATF2(1), AXIN1(5), BMP10(1), BMP4(1), BMP7(1), BMPR1A(1), CHRD(3), FZD1(2), GSK3B(2), MAP3K7(1), NKX2-5(4), NOG(1), RFC1(2), TGFB1(2), TGFBR1(1), TGFBR2(1)	9207882	33	26	33	19	14	3	7	2	6	1	0.971	1.000	1.000
516	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(1), CAMK2A(4), CAMK2B(1), CDK5(1), F2(1), GNA11(1), GNB1(2), HRAS(1), JAK2(3), MAP2K2(1), PLCG1(1), PTK2B(1), RAF1(2), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(3)	10603309	33	26	33	17	11	3	6	6	7	0	0.965	1.000	1.000
517	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(2), GNAS(3), GNB1(2), HRAS(1), IGF1R(4), ITGB1(5), KLK2(1), MAP2K2(1), PDGFRA(1), PTPRR(3), RAF1(2), RPS6KA1(2), SHC1(1), SOS1(3), SRC(2), STAT3(1)	8426231	35	26	35	15	13	5	4	5	8	0	0.881	1.000	1.000
518	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(3), ARRB2(2), CAMK2A(4), CAMK2B(1), CLCA1(3), CLCA2(2), CLCA4(1), CNGA3(2), CNGA4(2), CNGB1(5), GUCA1B(1), PDE1C(1), PRKACA(2), PRKACB(1), PRKACG(1), PRKG1(1), PRKG2(3), PRKX(3)	7751811	41	26	40	20	21	4	10	1	5	0	0.919	1.000	1.000
519	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), AOX1(1), DBH(1), DCT(2), DDC(3), GOT1(2), GOT2(2), HGD(1), HPD(3), MAOA(2), MAOB(4), PNMT(1), TPO(1)	8031512	38	26	38	19	20	5	7	3	3	0	0.899	1.000	1.000
520	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(6), ATR(4), BRCA1(3), BRCA2(7), CHEK1(2), CHEK2(2), FANCA(2), FANCD2(4), FANCG(1), MRE11A(3), RAD50(2), TREX1(1)	10863033	37	25	37	20	16	4	4	10	3	0	0.992	1.000	1.000
521	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), FOS(1), HRAS(1), LYN(1), MAP3K1(7), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SYK(2), VAV1(1)	9622949	37	25	37	16	19	2	4	3	9	0	0.926	1.000	1.000
522	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), B4GALT2(1), GAA(2), GALE(4), GCK(2), GLA(1), GLB1(1), HK1(1), HK2(2), LCT(5), MGAM(6), PFKP(3), PGM1(2), PGM3(1)	8287226	33	25	33	23	16	3	6	1	7	0	0.998	1.000	1.000
523	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(3), ALDOC(1), G6PD(1), H6PD(2), PFKL(4), PFKP(3), PGM1(2), PGM3(1), PRPS1(1), PRPS2(3), RBKS(1), RPE(2), RPIA(1), TKT(2), TKTL2(1)	6154261	28	25	28	11	12	1	7	2	6	0	0.713	1.000	1.000
524	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), DDC(3), EPX(3), ESCO2(1), GOT1(2), GOT2(2), HPD(3), MAOA(2), MAOB(4), MPO(3), PNPLA3(1), PRDX6(2), TPO(1)	8635537	36	25	36	12	15	4	8	5	4	0	0.495	1.000	1.000
525	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT6(1), AGPS(7), CHPT1(1), ENPP6(1), PAFAH1B2(2), PAFAH2(2), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), PLD1(2), PLD2(1), PPAP2C(1)	5899293	33	25	33	12	18	2	6	2	5	0	0.609	1.000	1.000
526	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(1), ADCY3(3), ADCY9(7), ARF3(2), ARF5(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1H(1), GNAS(3), PDIA4(1), PLCG1(1), PLCG2(4), SEC61B(2), TRIM23(2)	9386648	39	25	39	19	16	4	9	5	5	0	0.919	1.000	1.000
527	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(2), DDC(3), EPX(3), GOT1(2), GOT2(2), HPD(3), MAOA(2), MAOB(4), MPO(3), PRDX2(1), PRDX6(2), TPO(1)	5584755	35	25	35	12	14	4	7	6	4	0	0.452	1.000	1.000
528	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(1), GTF2B(3), NCOA1(1), NCOA2(8), NCOA3(6), NCOR2(8), POLR2A(4), RXRA(2)	6365182	36	25	35	19	21	2	7	4	2	0	0.942	1.000	1.000
529	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(3), GTF2B(3), POLR1A(1), POLR1B(2), POLR2A(4), POLR2B(4), POLR2F(1), POLR2I(1), POLR2J(1), POLR3B(3), POLR3E(1), TAF5(1), TAF6(1), TAF7(2)	8884932	29	25	29	16	10	2	9	4	4	0	0.983	1.000	1.000
530	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K7(2), MAPK10(2), MAPK12(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), PIK3CA(2), PIK3CD(1), PIK3R1(3), TRAF2(1), TRAF5(2)	8635958	35	25	34	16	13	3	8	4	7	0	0.902	1.000	1.000
531	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), AXIN1(5), BTRC(1), CREBBP(5), CSNK1A1(1), CSNK1D(1), CSNK2A1(5), CTBP1(3), FZD1(2), GSK3B(2), MAP3K7(1), NLK(2), PPARD(1), TLE1(2), WIF1(2)	7481270	34	25	34	12	19	1	5	3	5	1	0.680	1.000	1.000
532	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CFLAR(1), DAXX(2), FADD(1), LMNA(3), LMNB2(1), MAP3K1(7), MAP3K7(1), PAK1(1), PRKDC(4), PTPN13(7), RIPK2(4), SPTAN1(6)	10475175	40	24	40	24	18	4	4	3	10	1	0.998	1.000	1.000
533	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(1), AXIN1(5), CD14(1), FZD1(2), GSK3B(2), LBP(1), LEF1(2), LY96(1), NFKB1(3), PIK3CA(2), PIK3R1(3), RELA(2), TLR4(3), TOLLIP(1)	7760317	30	24	30	14	15	2	5	4	4	0	0.893	1.000	1.000
534	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(3), IKBKB(3), IL1B(1), IL1R1(1), IL1RN(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP3K7(1), NFKB1(3), NFKBIA(2), RELA(2), TGFB1(2), TNF(1), TOLLIP(1)	7505198	32	24	32	13	13	3	5	3	7	1	0.861	1.000	1.000
535	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(2), CREB3(3), DUSP4(3), DUSP6(3), EEF2K(5), MAP2K2(1), MAP3K8(1), NFKB1(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(3)	7505606	36	24	35	11	14	2	5	9	6	0	0.550	1.000	1.000
536	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), ATF2(1), EGFR(2), HRAS(1), MAP2K2(1), MAP3K1(7), MEF2A(2), PAK1(1), PTK2(1), PTK2B(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SRC(2)	8514774	29	23	29	10	12	2	4	4	7	0	0.740	1.000	1.000
537	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ALDH1A2(2), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), EHHADH(2), GAD1(4), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(2), OXCT1(1), SDHB(2)	6523592	33	23	33	14	18	1	4	7	3	0	0.800	1.000	1.000
538	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(2), DDX20(4), ETS1(1), FOS(1), HDAC5(3), HRAS(1), NCOR2(8), RBL1(2), RBL2(4), SIN3A(5), SIN3B(5)	6728713	37	23	36	14	18	3	6	4	6	0	0.683	1.000	1.000
539	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), FOS(1), GNAS(3), GNB1(2), HRAS(1), NFATC1(1), NFATC2(3), NFATC3(3), NFATC4(4), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(2), RPS6KA3(2)	8829031	33	23	33	16	15	2	4	5	7	0	0.976	1.000	1.000
540	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(1), C6(2), C7(2), ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(5), ITGB2(3), SELP(2), SELPLG(1), TNF(1), VCAM1(2)	6235160	28	23	28	10	10	2	6	6	4	0	0.699	1.000	1.000
541	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(6), BMPR1B(1), CDK4(1), DAZL(1), ESR2(2), MLH1(4), MSH5(1), NCOR1(4), PGR(2), PRLR(1), SMPD1(3), VDR(1), ZP2(4)	8804766	31	23	31	19	14	1	10	3	3	0	0.988	1.000	1.000
542	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(3), MAP3K1(7), NFATC1(1), NFATC2(3), NFKB1(3), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), VIP(1), VIPR2(1)	7031527	33	23	33	14	15	1	4	3	10	0	0.928	1.000	1.000
543	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), BAD(1), CHRNB1(3), CHRNG(1), MUSK(1), PIK3CA(2), PIK3R1(3), PTK2(1), PTK2B(1), RAPSN(1), SRC(2), TERT(8)	4171660	25	22	25	11	10	2	5	5	3	0	0.829	1.000	1.000
544	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(7), IRS1(1), PABPC1(1), PIK3CA(2), PIK3R1(3), PTEN(5)	7091018	26	22	26	11	4	0	8	5	9	0	0.913	1.000	1.000
545	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(3), ALDOC(1), GCK(2), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), HK2(2), KHK(3), PFKFB1(1), PFKFB3(2), PFKFB4(1), PFKP(3), PMM1(1), TPI1(3)	6093093	28	22	28	18	9	4	4	5	6	0	0.988	1.000	1.000
546	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(6), ATM(6), ATR(4), CCNA1(1), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(2), GSK3B(2), SKP2(1), TFDP1(1), TGFB1(2)	7401230	30	22	30	14	16	3	3	4	4	0	0.907	1.000	1.000
547	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(1), ALG12(1), ALG2(2), ALG3(1), ALG5(1), ALG6(3), ALG9(2), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(2), MAN1B1(1), MAN1C1(3), MAN2A1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(1), MGAT5B(3), RFT1(3), RPN1(1), RPN2(1), ST6GAL1(1)	10758442	36	22	36	12	19	2	5	2	8	0	0.621	1.000	1.000
548	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(2), AP2M1(2), BIN1(3), DNM1(3), EPS15(3), NME1(1), PICALM(2), PPP3CA(3), PPP3CB(1), SYNJ1(4), SYNJ2(2)	5567873	28	22	28	11	12	3	2	7	4	0	0.844	1.000	1.000
549	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(3), ALDOC(1), G6PD(1), H6PD(2), PFKP(3), PGM1(2), PGM3(1), PRPS1(1), PRPS2(3), RBKS(1), RPE(2), RPIA(1), TAL1(3), TKT(2)	5139463	26	22	26	10	11	1	7	2	5	0	0.700	1.000	1.000
550	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(11), LPL(1), NCOA1(1), NCOA2(8), RXRA(2)	4642185	28	22	28	12	13	1	6	3	5	0	0.933	1.000	1.000
551	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(3), BLNK(1), FOS(1), HRAS(1), LYN(1), MAP3K1(7), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(3), SYK(2), VAV1(1), VAV2(1), VAV3(5)	8131165	41	22	39	20	19	3	5	3	11	0	0.968	1.000	1.000
552	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), ASAH1(1), CAMP(1), CERK(1), CREB3(3), DAG1(6), FOS(1), ITPKA(3), ITPKB(3), MAP2K7(2), MAPK10(2), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(4), MAPK9(2)	7236392	34	22	33	16	15	3	3	5	8	0	0.931	1.000	1.000
553	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(6), ATM(6), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(2), MDM2(1), MRE11A(3), NFKB1(3), NFKBIA(2), RAD50(2), RBBP8(4), RELA(2)	7276619	37	21	37	18	18	2	6	6	5	0	0.970	1.000	1.000
554	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(1), ATM(6), BAD(1), BID(2), CASP9(2), PTK2(1), PXN(1), STAT1(2), TLN1(10)	6702099	27	21	27	15	9	2	4	8	4	0	0.976	1.000	1.000
555	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), GNB1(2), HRAS(1), NFKB1(3), PIK3C2G(6), PIK3CA(2), PIK3R1(3), PLCG1(1), PTK2(1), PTK2B(1), PXN(1), RAF1(2), RELA(2)	7065057	27	21	27	11	9	1	6	4	7	0	0.902	1.000	1.000
556	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	HRAS(1), INS(3), INSR(3), IRS1(1), JAK2(3), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1), STAT5A(3), STAT5B(2)	8360360	32	21	32	13	13	4	6	3	6	0	0.903	1.000	1.000
557	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(3), CRKL(1), FOS(1), HRAS(1), JAK2(3), MAP3K1(7), PIK3CA(2), PIK3R1(3), RAF1(2), SOS1(3), STAT1(2), STAT5A(3), STAT5B(2)	7052910	34	21	34	16	13	2	6	3	10	0	0.968	1.000	1.000
558	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GLB1(1), GNS(1), HGSNAT(6), HPSE(2), HPSE2(2), HYAL1(2), HYAL2(1), IDUA(5), LCT(5), NAGLU(4), SPAM1(1)	5250513	31	21	28	12	15	0	5	8	3	0	0.749	1.000	1.000
559	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP3A4(2), CYP3A43(2), CYP3A7(1), PLA2G12A(2), PLA2G2D(3), PLA2G3(1), PLA2G4A(3), PLA2G6(3), RDH11(2), RDH13(1)	6057940	28	21	28	10	15	3	3	2	5	0	0.653	1.000	1.000
560	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(1), EIF2S3(1), EIF4EBP1(1), GSK3B(2), IGF1R(4), INPPL1(3), PIK3CA(2), PIK3R1(3), PTEN(5)	4994725	23	21	23	12	6	2	7	3	5	0	0.978	1.000	1.000
561	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(1), CAP1(2), CCNB1(1), CDC25C(1), GNAS(3), GNB1(2), HRAS(1), MYT1(7), PIN1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2), SRC(2)	5231907	29	21	29	16	14	3	4	5	3	0	0.978	1.000	1.000
562	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CRKL(1), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), PAK1(1), PLCG1(1), PTK2B(1), RAC1(1), RAF1(2), SHC1(1), SOS1(3), SRC(2)	7221511	26	21	26	11	9	3	5	2	7	0	0.905	1.000	1.000
563	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC3(1), CFLAR(1), FADD(1), MAP3K7(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIL1(1), NR2C2(3), RALBP1(4), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	6936541	27	21	26	13	6	4	8	2	6	1	0.928	1.000	1.000
564	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CHUK(3), IKBKB(3), LTA(1), MAP2K3(2), MAP3K1(7), MAP3K14(2), MAP4K2(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TRADD(1), TRAF2(1)	6149550	30	21	30	12	13	4	3	3	7	0	0.865	1.000	1.000
565	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(5), EP300(11), NCOA3(6), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RXRA(2)	5224299	30	20	30	11	15	2	3	3	7	0	0.846	1.000	1.000
566	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K2(1), MAP2K3(2), MAP3K1(7), NFKB1(3), PIK3CA(2), PIK3R1(3), RELA(2)	4916307	21	20	21	11	7	3	4	2	5	0	0.975	1.000	1.000
567	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), CYP2C19(1), CYP2C9(1), DHRS1(1), DHRS2(1), EHHADH(2), ESCO2(1), HADHA(3), PNPLA3(1), YOD1(1)	7790327	26	20	26	11	13	1	4	6	2	0	0.833	1.000	1.000
568	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN2A(2), GRIN2B(5), GRIN2C(1), GRIN2D(3), NOS1(4), PPP3CA(3), PPP3CB(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	6515236	27	20	27	13	16	0	3	4	4	0	0.900	1.000	1.000
569	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(2), BAD(1), EEA1(2), GSK3A(1), GSK3B(2), LYN(1), PFKL(4), PFKP(3), PLCG1(1), PRKCE(2), RAC1(1), VAV2(1)	6286022	24	20	24	19	9	2	6	5	2	0	0.999	1.000	1.000
570	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), FADD(1), MAP3K1(7), NFKB1(3), NSMAF(4), RAF1(2), RELA(2), RIPK1(1), SMPD1(3), TRADD(1), TRAF2(1)	5186412	26	19	26	11	9	4	4	2	7	0	0.926	1.000	1.000
571	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), AKT1(1), CAMK2A(4), CAMK2B(1), GNAS(3), HRAS(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(3)	7395197	27	19	27	22	9	2	7	3	6	0	1.000	1.000	1.000
572	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(3), LCT(5), PGM1(2), PYGL(2), PYGM(4), TPI1(3), TREH(2)	3412171	22	19	22	12	11	2	4	4	1	0	0.899	1.000	1.000
573	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(2), RPE(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UGT2A1(4), UGT2A3(1), UGT2B10(1), UGT2B17(1), UGT2B28(1), UGT2B7(2), XYLB(1)	6829202	23	19	23	10	10	2	1	8	2	0	0.900	1.000	1.000
574	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1B(1), ADRA2C(1), CHRM1(2), CHRM2(3), CHRM3(2), DRD4(2), DRD5(3), HRH2(1), HTR1B(1), HTR2A(1), HTR2B(1), HTR4(1), HTR6(1), HTR7(1)	6507134	24	19	24	10	13	2	7	2	0	0	0.470	1.000	1.000
575	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(4), ITGB1(5), ITGB2(3), SELE(1), SELL(2), SELP(2)	4057562	23	19	23	10	8	3	5	3	4	0	0.856	1.000	1.000
576	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(2), HRAS(1), MAP3K1(7), MAP3K5(1), MAP3K7(1), MAP3K9(5), MAX(1), MEF2A(2), PLA2G4A(3), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB1(2), TGFBR1(1), TRADD(1), TRAF2(1)	9316831	35	19	35	19	21	1	4	2	6	1	0.969	1.000	1.000
577	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CDC42(1), CREB3(3), EEF2K(5), IL1R1(1), MAP2K3(2), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAP3K7(1), MAPK12(2), MYEF2(1), NFKB1(3), NR2C2(3), SRF(1)	8497615	27	19	26	16	13	4	5	1	3	1	0.974	1.000	1.000
578	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), AKT1(1), BAD(1), CSF2RB(2), IGF1R(4), KIT(1), PIK3CA(2), PIK3R1(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	5529329	20	18	20	16	7	3	3	3	4	0	0.999	1.000	1.000
579	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(1), CD5(1), CD7(1), IL10(1), ITGAX(5), TLR2(2), TLR4(3), TLR7(5)	4690258	24	18	24	10	13	3	4	2	2	0	0.582	1.000	1.000
580	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(2), EXTL1(1), GLCE(2), HS2ST1(2), HS3ST2(1), HS3ST3A1(1), HS6ST2(3), HS6ST3(1), NDST1(3), NDST2(1), NDST3(2), NDST4(2)	5278458	21	18	21	12	9	4	3	3	2	0	0.944	1.000	1.000
581	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CD4(2), CREBBP(5), CSK(1), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(2)	5826711	24	17	24	12	10	2	3	3	6	0	0.962	1.000	1.000
582	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CD4(2), CREBBP(5), CSK(1), GNAS(3), GNB1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(2)	5826711	24	17	24	12	10	2	3	3	6	0	0.962	1.000	1.000
583	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(2), FUCA2(1), GLB1(1), LCT(5), MAN2B1(2), MAN2B2(2), MANBA(2), NEU1(1), NEU2(1), NEU4(2)	5203640	19	17	19	10	10	2	5	1	1	0	0.900	1.000	1.000
584	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(5), DPM2(1), FOS(1), HRAS(1), KLK2(1), PIK3CA(2), PIK3R1(3), PLCG1(1), RAF1(2), SHC1(1), SOS1(3)	4817336	21	17	21	11	7	0	5	3	6	0	0.955	1.000	1.000
585	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(3), EPRS(4), HMOX1(1), PPOX(1), UGT1A1(1), UGT1A3(1), UGT1A5(2), UGT1A9(2), UROD(1)	6897760	17	17	17	13	7	1	2	6	1	0	0.995	1.000	1.000
586	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), HRAS(1), MAPK7(3), MEF2A(2), NTRK1(5), PIK3CA(2), PIK3R1(3), PLCG1(1), RPS6KA1(2), SHC1(1)	4862805	21	16	20	15	6	5	7	2	1	0	0.995	1.000	1.000
587	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1)	3358679	19	16	19	9	10	2	2	5	0	0	0.834	1.000	1.000
588	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(4), ALDH2(3), ALDH3A1(1), ALDH3A2(4), ALDH9A1(1), MIOX(1), UGDH(1)	2164287	15	14	15	6	7	1	2	5	0	0	0.692	1.000	1.000
589	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS2(1), HEMK1(1), LCMT1(1), METTL2B(1), PRMT2(2), PRMT3(1), PRMT5(2), PRMT6(1), PRMT7(3), WBSCR22(1)	3796786	16	14	16	10	8	2	0	1	5	0	0.953	1.000	1.000
590	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA3(2), GABRA4(1), GPHN(7), SRC(2)	3012148	15	13	15	7	8	1	4	2	0	0	0.816	1.000	1.000
591	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(3), AKT3(1), CDKN1A(1), HRAS(1), MAP2K2(1), NTRK1(5), PIK3CA(2), PIK3CD(1), SHC1(1), SOS1(3)	4127604	20	13	20	11	6	3	7	2	2	0	0.914	1.000	1.000
592	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(1), GLI3(3), GSK3B(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SHH(1), SUFU(3)	4204187	17	13	17	10	8	2	2	2	3	0	0.957	1.000	1.000
593	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), DPM2(1), HRAS(1), KLK2(1), NTRK1(5), PIK3CA(2), PIK3R1(3), PLCG1(1), SHC1(1), SOS1(3)	3928785	19	13	19	13	7	2	6	1	3	0	0.991	1.000	1.000
594	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(2), C1S(1), C2(2), C3(3), C5(1), C6(2), C7(2), C8A(1), MASP1(1)	5272046	16	12	16	6	9	2	2	3	0	0	0.701	1.000	1.000
595	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(1), CCR2(1), CCR3(2), CCR5(1), CCR7(2), CD4(2), IFNGR1(1), IL12RB1(3), IL12RB2(1), IL4R(1), TGFB1(2)	5065355	18	12	18	11	8	3	0	3	4	0	0.967	1.000	1.000
596	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CSNK1D(1), PLCB1(2), PPP1CA(2), PPP3CA(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	4045074	14	11	14	10	7	1	0	3	3	0	0.987	1.000	1.000
597	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(2), ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1), DHRS1(1), DHRS2(1), ESCO2(1), PNPLA3(1)	6269192	14	11	14	9	8	1	3	2	0	0	0.962	1.000	1.000
598	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), GNB1(2), PRKAB1(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	3902015	16	10	16	10	8	1	2	2	3	0	0.980	1.000	1.000
599	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), HK1(1), PFKL(4), PKLR(1), TPI1(3)	2340565	12	10	12	11	5	1	2	1	3	0	0.984	1.000	1.000
600	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR161(2), GPR18(2), GPR39(2), GPR65(2), GPR68(1)	2472067	9	8	9	5	4	1	4	0	0	0	0.761	1.000	1.000
601	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(1), HK2(2), PGM1(2), PGM3(1)	2974491	8	8	8	6	4	2	2	0	0	0	0.917	1.000	1.000
602	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK2(2), PGM1(2), PGM3(1)	2607302	8	8	8	6	4	2	2	0	0	0	0.925	1.000	1.000
603	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), GNB1(2), PRKACA(2)	1680489	8	7	8	4	4	1	1	2	0	0	0.904	1.000	1.000
604	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ATF3(1), CYR61(1), EIF4EBP1(1), HBEGF(1), IL1R1(1), MYOG(1), WDR1(2)	2739783	8	7	8	6	4	1	2	1	0	0	0.958	1.000	1.000
605	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(4), CDK5(1), CSNK1A1(1), CSNK1D(1), GSK3B(2)	2396777	10	7	10	9	8	1	0	1	0	0	0.983	1.000	1.000
606	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH4(2), ADH6(1), ADHFE1(1)	1410805	6	6	6	3	4	1	0	1	0	0	0.868	1.000	1.000
607	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(3), AOC3(2), CES1(1), ESD(1)	1516732	7	6	7	6	3	0	2	2	0	0	0.954	1.000	1.000
608	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(2), GABRA4(1), GPX1(1), PRKCE(2)	1886637	6	6	6	7	2	0	4	0	0	0	0.992	1.000	1.000
609	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), THBS1(5)	1844317	7	6	7	10	1	0	0	3	3	0	1.000	1.000	1.000
610	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), RDH11(2), RDH13(1)	1211630	5	4	5	3	4	0	0	1	0	0	0.845	1.000	1.000
611	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI2(1), SQLE(1)	1086143	4	4	4	3	1	1	2	0	0	0	0.948	1.000	1.000
612	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(1), ESCO2(1), PNPLA3(1)	4147712	4	3	4	4	3	0	1	0	0	0	0.968	1.000	1.000
613	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), SQLE(1)	816578	3	3	3	3	1	1	1	0	0	0	0.973	1.000	1.000
614	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(1), WT1(1)	1573042	2	2	2	2	2	0	0	0	0	0	0.928	1.000	1.000
615	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		182034	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		383227	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
