rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 98644 2 2 2 0 1 0 0 0 1 0 0.514 0.0140 1.000 2 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRB1(3) 332581 3 3 3 1 0 0 2 1 0 0 0.742 0.0649 1.000 3 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1), HLA-DRB1(3), IL3(1) 411853 6 5 6 2 0 0 4 2 0 0 0.680 0.0876 1.000 4 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 672997 6 5 6 1 1 0 2 1 2 0 0.541 0.0954 1.000 5 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 GLUD1(1), PRODH(4) 817853 5 5 4 0 1 1 0 3 0 0 0.252 0.0975 1.000 6 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(1), GOT2(2), LDHA(3) 920795 7 7 7 2 3 0 2 1 1 0 0.652 0.110 1.000 7 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2) 360688 3 3 3 0 2 0 1 0 0 0 0.399 0.115 1.000 8 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS2(1), SUOX(2) 824400 6 5 6 1 0 0 3 0 2 1 0.783 0.126 1.000 9 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1) 975354 7 6 7 0 1 0 4 0 2 0 0.215 0.141 1.000 10 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT3(3), FUT6(2) 715421 5 5 5 1 2 0 2 1 0 0 0.442 0.155 1.000 11 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(1), GOT1(1), GOT2(2) 1131322 6 6 6 1 3 0 1 2 0 0 0.436 0.168 1.000 12 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(1), HADHB(1), HSD17B4(3), MECR(1) 1183470 9 7 9 0 0 0 5 2 2 0 0.138 0.175 1.000 13 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 3 FDFT1(1), SQLE(2) 385769 3 3 3 0 0 0 3 0 0 0 0.445 0.177 1.000 14 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(3) 835413 5 5 5 1 2 0 2 0 1 0 0.407 0.215 1.000 15 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 5 ADCY1(1), GNAS(5), GNB1(2), PRKACA(1) 823684 9 8 9 2 1 0 3 2 3 0 0.728 0.247 1.000 16 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(1), DAXX(4), PML(2), RARA(1), RB1(2), SIRT1(1), TNFRSF1A(1) 2463401 12 9 12 1 1 1 3 0 7 0 0.252 0.259 1.000 17 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(1), ATM(5), MDM2(2), RB1(2), TIMP3(1) 2325766 11 10 11 2 0 0 2 0 9 0 0.656 0.275 1.000 18 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(2), CHIT1(3), CTBS(1), GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3), LHPP(2), MTMR1(1), MTMR2(1) 3988034 21 19 19 4 1 3 10 2 5 0 0.309 0.276 1.000 19 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), HLA-DRB1(3) 734916 5 4 5 2 0 0 3 2 0 0 0.778 0.287 1.000 20 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 BDKRB2(1), KNG1(1), NOS3(4) 1392698 6 6 6 1 2 1 2 1 0 0 0.356 0.297 1.000 21 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(1), SIRT1(1) 1646424 11 8 11 0 0 0 6 2 3 0 0.0870 0.303 1.000 22 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FSHR(1), GNAS(5), XPO1(1) 1325962 8 7 8 1 2 0 2 2 2 0 0.463 0.305 1.000 23 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 5 FDFT1(1), SQLE(2) 528557 3 3 3 0 0 0 3 0 0 0 0.453 0.310 1.000 24 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF3(1), CDKN2A(2), MDM2(2) 1018468 5 5 5 1 0 0 3 0 2 0 0.574 0.341 1.000 25 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 160064 1 1 1 0 0 0 1 0 0 0 0.783 0.342 1.000 26 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), GOT2(2) 642963 3 3 3 0 2 0 1 0 0 0 0.386 0.344 1.000 27 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), SDS(1) 1156648 6 5 6 1 1 0 2 1 2 0 0.567 0.349 1.000 28 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRB1(3), IL2(1) 550667 4 4 4 2 0 0 3 1 0 0 0.833 0.369 1.000 29 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(3) 1402971 7 6 7 0 0 0 5 1 1 0 0.190 0.372 1.000 30 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 224397 1 1 1 0 0 0 1 0 0 0 0.772 0.379 1.000 31 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(2) 898917 3 3 3 1 0 0 1 0 2 0 0.824 0.386 1.000 32 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GALT5(1), FUT3(3) 999590 5 5 5 0 2 0 2 1 0 0 0.210 0.389 1.000 33 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 231535 1 1 1 0 1 0 0 0 0 0 0.652 0.395 1.000 34 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3) 2357997 9 9 9 1 1 0 6 1 1 0 0.256 0.413 1.000 35 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 B2M(1), CD3D(1), GZMB(1), ICAM1(1), ITGAL(1) 1103154 5 5 5 1 2 0 2 0 1 0 0.516 0.415 1.000 36 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(1) 682537 3 3 3 0 0 0 2 0 1 0 0.608 0.423 1.000 37 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD1(1), GLUD2(1) 617313 2 2 2 0 1 0 0 1 0 0 0.570 0.425 1.000 38 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(5), BMPR1B(1), CCND2(1), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), MLH1(2), NCOR1(1), NR5A1(2), NRIP1(3), PGR(1), VDR(1) 4741926 22 16 22 3 2 2 8 1 9 0 0.296 0.430 1.000 39 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 FADS2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1) 1476693 8 7 8 0 1 0 3 1 3 0 0.169 0.431 1.000 40 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 204771 1 1 1 0 0 0 0 0 1 0 1.000 0.433 1.000 41 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 CMA1(1), CPA3(1), CTSA(2), ENPEP(3), LNPEP(1), MME(4), NLN(3) 2905448 15 13 15 3 1 2 9 1 1 1 0.325 0.440 1.000 42 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(1) 855203 5 4 5 0 1 1 2 1 0 0 0.278 0.444 1.000 43 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), DAXX(4) 1527421 5 5 5 1 0 1 0 0 4 0 0.715 0.456 1.000 44 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), EP300(2), EPO(1), LDHA(3), NOS3(4), P4HB(1) 2328228 12 11 12 2 1 1 5 3 2 0 0.365 0.462 1.000 45 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(3), HK3(3) 1448643 6 6 6 1 0 0 4 1 1 0 0.461 0.468 1.000 46 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(3), MAP2(2), PPP1CA(2), PRKACB(1) 2287748 8 8 8 1 0 0 3 1 4 0 0.649 0.469 1.000 47 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(1), HADHA(1), SDHB(1), SDS(1) 1070591 6 5 6 2 1 0 2 1 2 0 0.780 0.469 1.000 48 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ECHS1(2), HADHA(1) 747311 3 3 3 0 0 0 1 0 2 0 0.644 0.479 1.000 49 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(2), GPT(1), LDHA(3) 1258485 6 6 6 1 1 0 3 2 0 0 0.476 0.485 1.000 50 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(5), RB1(2) 2279442 7 7 7 5 0 0 1 0 6 0 0.994 0.497 1.000 51 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), LEPR(2), PRKAA2(1), PRKAG2(3) 1965351 8 7 8 1 2 1 3 0 2 0 0.400 0.508 1.000 52 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), CASP8(1), DFFA(1), GZMB(1), SCAP(4), SREBF2(2) 2606053 10 9 10 1 3 0 1 0 6 0 0.457 0.509 1.000 53 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 527377 3 2 3 0 0 0 1 0 2 0 0.437 0.510 1.000 54 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(1), MTMR2(1) 879691 4 4 3 2 0 3 0 0 1 0 0.872 0.519 1.000 55 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 NDUFA1(1), SDHA(1), SDHB(1), SDHD(1) 892258 4 3 4 1 0 0 2 2 0 0 0.697 0.520 1.000 56 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2B5(1), PPP1CA(2) 1565927 6 5 6 0 0 0 1 1 4 0 0.621 0.546 1.000 57 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCND2(1), CDKN2A(2), RB1(2), RBL1(1), TFDP1(1) 2172211 7 7 7 1 3 0 1 0 3 0 0.377 0.551 1.000 58 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(5), ATR(3), CHEK2(2) 2011007 10 9 10 3 1 0 2 2 5 0 0.865 0.568 1.000 59 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 8 CYP17A1(1), HSD17B4(3), HSD17B7(2) 1034378 6 4 6 2 1 0 3 1 1 0 0.750 0.600 1.000 60 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 274454 1 1 1 1 0 0 1 0 0 0 0.947 0.605 1.000 61 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL2L1(2), BCL2L11(1), CES1(1) 1569828 5 5 5 1 2 0 0 0 3 0 0.567 0.610 1.000 62 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(1), GNAS(5), GNB1(2), PRKAA2(1), PRKACB(1), PRKAG2(3) 2043067 13 10 13 3 2 1 4 2 4 0 0.627 0.622 1.000 63 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), KARS(1) 633927 2 2 2 1 1 0 1 0 0 0 0.863 0.628 1.000 64 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 DHCR7(1), FDFT1(1), HMGCR(1), NSDHL(1), SQLE(2) 1795143 6 6 6 1 0 0 4 1 1 0 0.591 0.628 1.000 65 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(2), SCAP(4), SREBF2(2) 1748855 9 6 9 1 3 0 2 0 4 0 0.424 0.640 1.000 66 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD8A(1), IL3(1) 855564 3 3 3 0 0 1 2 0 0 0 0.400 0.642 1.000 67 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(1), DFFA(1), GZMB(1) 1469864 5 5 5 1 2 0 2 1 0 0 0.507 0.645 1.000 68 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(1), FDFT1(1), HMGCR(1), NQO2(1), SQLE(2) 1507456 6 5 6 1 0 0 4 0 2 0 0.561 0.646 1.000 69 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(2), MMP9(1), RECK(1), TIMP3(1) 1061594 5 4 5 2 2 0 1 0 2 0 0.843 0.651 1.000 70 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR171(1), GPR34(1), GPR39(2), GPR68(1), GPR75(1) 1356933 7 6 7 2 1 0 5 1 0 0 0.511 0.653 1.000 71 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3) 1065202 3 3 3 0 0 0 1 2 0 0 0.475 0.663 1.000 72 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), GBGT1(2), HEXB(1), ST3GAL1(1) 1469519 7 6 7 1 2 0 3 1 1 0 0.397 0.673 1.000 73 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(2), GABRA2(2), GABRA6(2), GPX1(1) 897238 7 6 7 3 0 0 6 1 0 0 0.808 0.683 1.000 74 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(1), FADD(2), TNFRSF1A(1) 1155569 5 5 5 2 1 1 1 0 2 0 0.876 0.685 1.000 75 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), SNCAIP(1) 864719 2 2 2 1 0 0 2 0 0 0 0.877 0.692 1.000 76 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1) 517587 1 1 1 1 0 0 0 0 1 0 1.000 0.693 1.000 77 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(1), LARS(1), LARS2(1), PDHB(1) 1362163 6 6 6 2 0 0 2 3 1 0 0.829 0.693 1.000 78 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 RB1(2), TFDP1(1) 1162888 3 3 3 1 1 0 0 0 2 0 0.693 0.701 1.000 79 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1) 431503 1 1 1 0 0 0 1 0 0 0 0.759 0.705 1.000 80 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 RB1(2), TFDP1(1) 1182150 3 3 3 1 1 0 0 0 2 0 0.685 0.708 1.000 81 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT5(2), ST3GAL1(1) 1072831 3 3 3 0 1 0 0 2 0 0 0.493 0.709 1.000 82 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(5) 1885266 5 5 5 5 0 0 1 0 4 0 0.999 0.715 1.000 83 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1) 447106 1 1 1 0 0 0 1 0 0 0 0.745 0.716 1.000 84 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 DFFA(1), GZMB(1), TOP2A(1) 1406398 3 3 3 1 2 0 1 0 0 0 0.782 0.718 1.000 85 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(1), CTH(1), GOT1(1), GOT2(2), LDHA(3), SDS(1) 1736578 9 9 9 3 4 0 2 2 1 0 0.663 0.719 1.000 86 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 308646 1 1 1 0 0 0 1 0 0 0 0.764 0.723 1.000 87 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 7 NDUFA12(1), NDUFB11(2) 498243 3 2 3 2 0 0 3 0 0 0 0.913 0.724 1.000 88 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1) 776498 2 2 2 0 1 0 0 1 0 0 0.564 0.729 1.000 89 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 532068 1 1 1 1 0 0 1 0 0 0 0.928 0.741 1.000 90 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSB(1), GOT1(1), GOT2(2) 1202692 5 5 5 2 2 0 1 1 1 0 0.816 0.747 1.000 91 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(3), CHST11(1), CHST13(3), PAPSS2(1), SUOX(2) 1252465 10 8 9 4 0 0 4 3 2 1 0.886 0.751 1.000 92 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 7 ALPI(1), ALPP(1), SPR(1) 673609 3 2 3 1 0 1 2 0 0 0 0.708 0.753 1.000 93 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPS(1), CHPT1(2), ENPP2(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PPAP2C(1) 3271826 14 10 14 1 2 0 8 2 2 0 0.102 0.755 1.000 94 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 G6PD(2), GPX1(1), GPX7(1), GSS(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), OPLAH(3) 3177850 15 12 14 3 4 1 4 1 5 0 0.480 0.764 1.000 95 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(1), FUCA2(1), HEXB(1), LCT(1), MANBA(2) 2209266 6 6 6 0 1 0 1 3 1 0 0.266 0.765 1.000 96 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 GOT1(1), GOT2(2), GPT(1), GPT2(2), MDH2(1), PGK2(3), RPIA(1), TKTL2(3) 2792787 14 10 13 4 3 2 6 1 2 0 0.532 0.772 1.000 97 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(1), DBH(2), MAOA(3), SLC18A3(1), TH(3) 2021928 11 9 11 3 2 1 5 0 3 0 0.529 0.772 1.000 98 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), LCT(1) 1907327 7 5 7 1 2 1 2 2 0 0 0.317 0.775 1.000 99 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 464414 1 1 1 0 0 0 0 1 0 0 0.737 0.776 1.000 100 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH6(1), ADH7(2) 764432 3 3 3 5 1 0 0 1 1 0 0.999 0.776 1.000 101 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1) 812156 2 2 2 0 0 0 2 0 0 0 0.558 0.778 1.000 102 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BCL2L1(2), CASP8(1), DFFA(1) 1851028 5 5 5 1 2 0 0 0 3 0 0.686 0.781 1.000 103 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 RB1(2), TFDP1(1) 1151532 3 3 3 2 1 0 0 0 2 0 0.889 0.783 1.000 104 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXB(1), LCT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1) 2246514 6 6 6 1 2 0 2 1 1 0 0.487 0.786 1.000 105 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), GBGT1(2), HEXB(1), ST3GAL1(1) 1389093 5 4 5 1 1 0 2 1 1 0 0.618 0.788 1.000 106 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGFR(3), TF(1) 1743223 6 6 6 2 2 0 2 2 0 0 0.701 0.794 1.000 107 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPP(1), FLAD1(1) 1348104 3 3 3 1 0 0 2 1 0 0 0.762 0.798 1.000 108 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), MAPK1(1), NGFR(2) 1162579 5 5 5 1 3 0 1 1 0 0 0.386 0.800 1.000 109 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDHPPT(1), KARS(1) 929388 2 2 2 1 1 0 1 0 0 0 0.858 0.801 1.000 110 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 APC(4), CD14(1), DVL1(1), GJA1(2), IRAK1(2), LBP(1), NFKB1(1), PIK3CA(1), PIK3R1(1), TLR4(3), WNT1(2) 3889560 19 14 18 4 0 1 10 5 3 0 0.531 0.808 1.000 111 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), SHMT2(1) 605876 2 2 2 0 1 0 1 0 0 0 0.481 0.808 1.000 112 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 PTGS1(1), PTGS2(2) 724526 3 3 3 2 1 0 1 0 1 0 0.935 0.812 1.000 113 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 SHH(2), XPO1(1) 1188340 3 3 3 1 1 0 2 0 0 0 0.725 0.817 1.000 114 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1) 1339107 7 7 7 8 1 0 4 0 2 0 0.997 0.818 1.000 115 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1) 1339107 7 7 7 8 1 0 4 0 2 0 0.997 0.818 1.000 116 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 9 EPX(1), PRDX1(1), PRDX2(2) 1119029 4 4 4 2 2 0 0 0 2 0 0.947 0.825 1.000 117 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ALDH6A1(1), BCAT1(2), BCAT2(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HMGCS2(1), HSD17B4(3), MCCC1(2), MUT(1), OXCT1(1), PCCA(1) 6003604 19 16 19 0 0 0 10 6 3 0 0.0118 0.825 1.000 118 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1), CES1(1) 818102 2 2 2 1 2 0 0 0 0 0 0.780 0.825 1.000 119 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(5), TAF1L(1), TAF4(1), TAF4B(1), TAF7L(1), TBPL2(1) 4727690 13 11 13 1 2 0 8 1 2 0 0.182 0.827 1.000 120 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), BECN1(1), GABARAPL1(1), IFNA8(1), PIK3C3(1), PRKAA2(1), ULK1(1), ULK2(1), ULK3(1) 2929510 9 8 9 1 0 0 4 1 4 0 0.527 0.831 1.000 121 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB6A(1) 592069 1 1 1 0 0 0 0 1 0 0 0.794 0.836 1.000 122 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1) 1844537 5 4 5 1 1 1 1 1 1 0 0.562 0.837 1.000 123 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP72(3) 1026952 3 3 3 0 1 0 2 0 0 0 0.464 0.838 1.000 124 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2) 497015 2 1 2 1 0 0 2 0 0 0 0.813 0.841 1.000 125 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(2), MAPK1(1) 1270667 3 3 3 1 1 0 1 1 0 0 0.686 0.842 1.000 126 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), FDXR(2) 2209846 7 7 7 2 1 0 4 2 0 0 0.603 0.852 1.000 127 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ATM(5), CHEK2(2), MDM2(2), MRE11A(1), NFKB1(1), RAD50(3), RAD51(1), RBBP8(1), TP73(1) 3926482 17 13 17 4 1 0 6 2 8 0 0.730 0.855 1.000 128 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 1683340 5 4 5 1 1 0 2 0 2 0 0.606 0.858 1.000 129 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(3), TUB(1) 977439 7 7 7 3 2 0 4 1 0 0 0.759 0.861 1.000 130 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(1), ABCB11(1), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1) 1999026 8 8 8 3 3 1 2 2 0 0 0.667 0.862 1.000 131 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), LDLR(1) 728369 2 2 2 3 0 0 1 0 1 0 0.994 0.866 1.000 132 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACSL1(3), ACSL3(2), EHHADH(1), HADHA(1) 2304694 7 6 7 2 1 1 3 0 2 0 0.686 0.867 1.000 133 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 FUT3(3), FUT4(1), FUT6(2), GCNT2(1) 2210009 7 7 7 2 3 0 2 2 0 0 0.575 0.868 1.000 134 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(1), FUCA2(1), HEXB(1), LCT(1), MAN2B1(1), MANBA(2) 2756663 7 6 7 1 1 1 1 3 1 0 0.498 0.868 1.000 135 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2) 1075001 2 2 2 1 0 0 1 1 0 0 0.863 0.871 1.000 136 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 3687872 15 10 14 2 1 0 12 2 0 0 0.230 0.872 1.000 137 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(2), GALNT4(1), GALNT8(2), ST3GAL1(1) 2031805 7 5 7 1 0 0 2 2 3 0 0.593 0.874 1.000 138 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 10 ADCY1(1), CFTR(2), GNAS(5), PRKACB(1), SLC9A3R1(1) 1722160 10 7 10 3 1 0 3 2 4 0 0.761 0.874 1.000 139 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), FADD(2), MAP3K1(2), MAPK1(1), NFKB1(1), NSMAF(3), TNFRSF1A(1) 2807302 11 11 9 3 2 1 3 4 1 0 0.630 0.877 1.000 140 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), CASP8(1), GZMB(1) 1740691 3 3 3 1 1 0 0 0 2 0 0.822 0.881 1.000 141 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGP2(1) 691070 1 1 1 0 0 0 1 0 0 0 0.780 0.882 1.000 142 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1) 947361 7 4 7 3 2 1 4 0 0 0 0.681 0.882 1.000 143 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1) 947361 7 4 7 3 2 1 4 0 0 0 0.681 0.882 1.000 144 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), CYP17A1(1), HSD11B1(1) 953722 3 3 3 3 0 0 2 0 1 0 0.980 0.886 1.000 145 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 PFKL(2), PGAM1(1) 1273189 3 3 3 1 1 1 0 1 0 0 0.699 0.888 1.000 146 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCS2(1), OXCT1(1) 1024486 2 2 2 0 0 0 1 1 0 0 0.599 0.892 1.000 147 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(1), UGT1A3(1), UGT1A5(2), UGT2B15(2) 2374377 6 6 6 0 1 0 3 2 0 0 0.194 0.899 1.000 148 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1) 1843868 8 6 8 2 1 0 5 2 0 0 0.568 0.900 1.000 149 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(3) 1150369 4 3 4 2 1 0 2 1 0 0 0.799 0.902 1.000 150 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 FADD(2), IRAK1(2), MAP3K1(2), NFKB1(1), TLR4(3), TNFRSF1A(1) 3412238 11 10 10 3 2 1 6 2 0 0 0.563 0.902 1.000 151 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 G6PD(2), GPX1(1), GSS(1), GSTA2(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1) 2587866 10 10 10 3 2 1 2 1 4 0 0.793 0.906 1.000 152 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), CSF1(1), EPO(1), IL2(1), IL3(1) 865568 5 4 5 3 0 1 3 0 1 0 0.882 0.907 1.000 153 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(1), PEMT(1), SLC18A3(1) 966460 4 2 4 2 0 1 2 1 0 0 0.845 0.908 1.000 154 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 CDKN2A(2), MDM2(2), PIK3CA(1), PIK3R1(1), POLR1A(1), POLR1C(2), RB1(2), TBX2(1) 2634295 12 11 12 4 1 0 6 1 4 0 0.712 0.908 1.000 155 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 GCNT2(1) 869905 1 1 1 1 1 0 0 0 0 0 0.940 0.909 1.000 156 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1) 2572821 6 6 6 0 1 0 4 0 1 0 0.201 0.913 1.000 157 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(1) 980131 1 1 1 0 0 0 0 1 0 0 0.808 0.913 1.000 158 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(3), ERBB3(1) 1408354 4 4 4 2 2 0 2 0 0 0 0.837 0.915 1.000 159 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1) 1757779 7 6 7 2 1 0 4 2 0 0 0.639 0.916 1.000 160 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 12 ATP6V0C(1), EPX(1), PRDX1(1), PRDX2(2), SHMT2(1) 1414403 6 6 6 3 3 0 1 0 2 0 0.912 0.920 1.000 161 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACP6(1), ACPP(1), FLAD1(1), LHPP(2), MTMR1(1), MTMR2(1) 2095640 8 8 7 3 0 3 2 2 1 0 0.774 0.921 1.000 162 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(2), BCHE(2), CES1(1), UGT1A3(1), UGT1A5(2) 3108801 9 8 9 0 2 0 5 2 0 0 0.0688 0.925 1.000 163 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), FH(1), MDH2(1), SDHB(1) 1227121 4 3 4 2 0 0 3 1 0 0 0.871 0.926 1.000 164 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSL(1), ADSS(1), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), PC(1) 3648758 13 11 12 3 3 2 4 2 2 0 0.461 0.932 1.000 165 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1(6) 902045 7 6 5 6 1 0 3 2 1 0 0.984 0.934 1.000 166 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(1), CP(1), EPRS(4), GUSB(1), UGT1A3(1), UGT1A5(2), UGT2B15(2) 3727806 14 10 14 3 2 0 6 5 1 0 0.406 0.934 1.000 167 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1) 2334131 8 7 7 2 1 1 3 2 1 0 0.645 0.934 1.000 168 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(1), JAK2(2) 1115155 3 2 3 2 0 0 1 2 0 0 0.921 0.935 1.000 169 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CDKN2A(2) 1232801 2 2 2 1 0 0 1 0 1 0 0.922 0.936 1.000 170 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1), TANK(1) 3164258 7 7 7 1 1 0 5 0 1 0 0.389 0.937 1.000 171 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(2), NRG3(2) 1241813 9 6 8 4 2 0 5 2 0 0 0.794 0.938 1.000 172 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(1), PIK3R1(1), PLCB1(3), PLCG1(3), VAV1(3) 1784197 11 9 11 4 5 0 3 2 1 0 0.756 0.939 1.000 173 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GRM1(3), PLCB1(3), PPP1CA(2), PRKACB(1) 2102396 9 6 9 3 1 0 2 2 4 0 0.795 0.940 1.000 174 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ALDH6A1(1), BCAT1(2), ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), SDS(1) 4973049 14 13 14 2 1 0 5 5 3 0 0.283 0.940 1.000 175 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(1), ATM(5), IGFBP3(1), MDM2(2) 2742474 9 8 9 8 1 0 2 1 5 0 0.997 0.940 1.000 176 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB1(2), PSMB3(1), PSMB5(1), PSMC2(2), PSMD6(1) 2199119 7 4 7 1 1 0 3 2 1 0 0.510 0.941 1.000 177 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 LRP8(1), RELN(7) 1915796 8 7 8 3 0 0 5 3 0 0 0.755 0.942 1.000 178 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC2(1) 1134013 1 1 1 3 0 0 0 0 1 0 1.000 0.943 1.000 179 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BCL2L1(2), CASP8(1), FADD(2), GZMB(1), MAP3K1(2), MDM2(2), NFKB1(1), PARP1(3), TNFRSF1A(1) 5037470 16 14 16 3 4 1 7 0 4 0 0.289 0.944 1.000 180 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1) 1736445 5 4 5 5 1 0 1 1 2 0 0.995 0.948 1.000 181 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), PCYT1B(1), WBSCR22(1) 1947781 5 5 5 2 0 1 3 1 0 0 0.723 0.949 1.000 182 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ATM(5), ATR(3), CDKN2A(2), HDAC1(1), RB1(2), TFDP1(1) 3990408 14 12 14 9 2 0 4 1 7 0 0.994 0.949 1.000 183 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), GATA1(1) 1138108 3 3 3 2 1 0 1 1 0 0 0.899 0.951 1.000 184 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(2), MEF2C(2) 1182409 4 3 4 2 1 0 1 1 1 0 0.885 0.952 1.000 185 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(1), CPS1(3), EPRS(4), GLUD1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), GSS(1), NADSYN1(2), QARS(1) 4592245 21 14 21 4 2 3 7 4 5 0 0.361 0.952 1.000 186 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT2(1) 802826 1 1 1 0 1 0 0 0 0 0 0.673 0.955 1.000 187 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR2(1), NFKB1(1), TNFRSF11A(1), TNFSF11(1) 1522686 5 5 5 2 1 0 4 0 0 0 0.757 0.956 1.000 188 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2079943 5 5 5 2 1 0 3 1 0 0 0.741 0.957 1.000 189 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2079943 5 5 5 2 1 0 3 1 0 0 0.741 0.957 1.000 190 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2079943 5 5 5 2 1 0 3 1 0 0 0.741 0.957 1.000 191 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IL2(1), TGFBR2(2), TGFBR3(4), TOB2(1) 1478829 9 7 9 6 1 0 5 1 2 0 0.975 0.957 1.000 192 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(5), ATR(3), BRCA2(1), CHEK2(2), FANCF(1), MRE11A(1), RAD1(1), RAD17(1), RAD50(3), RAD51(1), RAD9A(1) 5841652 20 18 20 8 3 0 3 5 9 0 0.962 0.957 1.000 193 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(2), MAP2K3(2), NFATC1(1), PRKACB(1) 1569128 6 3 6 1 0 0 3 1 2 0 0.627 0.958 1.000 194 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL3(1), ITGAX(1), TLR2(2), TLR4(3), TLR7(1), TLR9(2) 2556677 10 8 10 3 0 0 8 1 1 0 0.590 0.960 1.000 195 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(2), ACACB(4), ACSS2(1), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1) 5424937 17 13 17 3 2 0 10 2 3 0 0.347 0.960 1.000 196 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB1(2), PSMB3(1), PSMB5(1), PSMB9(1) 1212754 5 2 5 1 1 0 4 0 0 0 0.577 0.961 1.000 197 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), NFKB1(1), PLCB1(3) 2123469 5 4 5 1 1 0 2 2 0 0 0.511 0.961 1.000 198 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 10 ARRB1(1), GNAS(5), GNB1(2), PRKACB(1) 1269537 9 7 9 3 1 0 3 2 3 0 0.827 0.962 1.000 199 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 CEBPB(1), CLDN5(3), CRY2(1), GFRA1(3), GSTP1(1), HSPA8(1), KLF9(1), NCKAP1(1), NCOA4(2), PER1(1), UGP2(1), VAPA(1), ZFR(1) 5027053 18 14 18 4 3 1 8 5 1 0 0.410 0.970 1.000 200 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5B(1), GPRC5D(1), GRM1(3), GRM3(4), GRM4(1), GRM5(1), GRM8(4) 2875920 19 8 19 4 1 1 12 3 2 0 0.226 0.970 1.000 201 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 WDR1(2) 1518981 2 2 2 2 0 0 0 1 1 0 0.981 0.971 1.000 202 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 APAF1(1), ATM(5), BCL2L1(2), TLN1(2) 3627565 10 9 10 5 2 0 2 0 6 0 0.959 0.971 1.000 203 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(3), GLUD1(1), GOT1(1) 1070012 5 4 5 3 1 0 2 1 1 0 0.916 0.973 1.000 204 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), PRKACB(1) 1385435 4 3 4 2 0 0 2 0 2 0 0.930 0.973 1.000 205 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2B(2), POLR2H(1), POLRMT(5) 1869478 8 8 5 3 1 4 2 0 1 0 0.766 0.973 1.000 206 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), TUBA8(2) 1557481 4 4 4 2 2 0 1 1 0 0 0.753 0.974 1.000 207 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1456665 7 6 7 3 0 1 2 2 2 0 0.846 0.974 1.000 208 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1456665 7 6 7 3 0 1 2 2 2 0 0.846 0.974 1.000 209 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 CHST1(1), ST3GAL1(1) 1682908 2 2 2 1 0 0 0 2 0 0 0.901 0.976 1.000 210 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), MAPK1(1), TYK2(2) 1678718 9 6 9 3 1 0 2 4 2 0 0.746 0.977 1.000 211 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1), TYK2(2) 1499568 4 4 4 2 1 0 1 0 2 0 0.848 0.978 1.000 212 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), CD8A(1), ICAM1(1), ITGAL(1) 1463437 4 4 4 2 1 1 2 0 0 0 0.782 0.978 1.000 213 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY2(1), PER1(1) 1194940 2 2 2 0 1 0 1 0 0 0 0.563 0.978 1.000 214 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), IRAK1(2), MAP2K3(2), MAP3K1(2), NFKB1(1), PPARA(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2) 5078289 18 15 17 4 1 1 9 5 2 0 0.485 0.978 1.000 215 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 AKR1C3(1), ALOX12(1), ALOX5(3), CYP4F2(1), CYP4F3(1), EPX(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PRDX1(1), PRDX2(2), PTGDS(1), PTGS1(1), PTGS2(2) 3720361 22 17 22 9 4 1 8 3 6 0 0.865 0.978 1.000 216 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 12 DYRK1B(1), GLI2(2), PRKACB(1), SHH(2), SMO(3), SUFU(1) 1763596 10 7 10 4 4 0 5 0 1 0 0.660 0.979 1.000 217 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(3), HK3(3) 1662155 6 6 6 3 0 0 4 1 1 0 0.852 0.980 1.000 218 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1) 1346924 1 1 1 2 0 0 0 0 1 0 0.974 0.980 1.000 219 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C6(1), C7(1), C9(3) 1748277 5 5 5 3 0 0 3 1 1 0 0.900 0.980 1.000 220 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), JAK1(1) 1674301 2 2 2 1 1 0 1 0 0 0 0.781 0.980 1.000 221 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(1), JAK2(2), PTPRU(1) 1575942 4 3 4 2 0 0 2 2 0 0 0.861 0.981 1.000 222 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1) 3437826 9 5 9 2 0 1 4 1 3 0 0.559 0.981 1.000 223 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(2), LCT(1), PYGL(1) 1911050 4 4 4 2 2 0 1 1 0 0 0.825 0.981 1.000 224 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK4(1), CAMKK2(1) 1658695 2 2 2 1 0 0 2 0 0 0 0.854 0.981 1.000 225 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(4) 1364446 5 5 4 3 1 1 2 0 1 0 0.900 0.982 1.000 226 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(2), ITGAL(1), SELE(1) 1705338 5 5 5 3 2 0 1 1 0 1 0.886 0.983 1.000 227 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 APC(4), DLL1(1), DVL1(1), NOTCH1(4), WNT1(2) 2676030 12 9 11 4 1 1 5 1 4 0 0.850 0.983 1.000 228 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC3(1), CES1(1), DDHD1(3), ESCO2(1), PNPLA3(2) 3434037 8 7 7 2 4 0 1 3 0 0 0.492 0.985 1.000 229 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3F(1) 995826 1 1 1 0 0 0 1 0 0 0 0.764 0.985 1.000 230 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 AOC3(1), EPX(1), GOT1(1), GOT2(2), MAOA(3), PRDX1(1), PRDX2(2) 2848731 11 10 11 4 5 0 2 0 4 0 0.800 0.985 1.000 231 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS3(1), PON1(1) 1238775 2 2 2 5 0 0 0 1 1 0 1.000 0.986 1.000 232 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), CR2(2), HLA-DRB1(3), ICAM1(1), ITGAL(1) 2098930 8 8 8 5 2 0 3 1 2 0 0.940 0.986 1.000 233 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(1), EP300(2), ESR1(1), MAPK1(1), PELP1(1) 2080413 6 6 6 3 0 0 2 2 2 0 0.943 0.987 1.000 234 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSD(2), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SPTLC1(1), SPTLC2(1) 3355778 10 9 10 3 1 0 8 0 1 0 0.537 0.989 1.000 235 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), HLA-DRB1(3), LCK(1), ZAP70(1) 1263516 6 6 6 3 0 0 4 1 1 0 0.832 0.989 1.000 236 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4R(1), JAK1(1), JAK3(3), STAT6(1) 2055244 6 5 6 2 1 1 2 2 0 0 0.704 0.989 1.000 237 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), CASP8(1), DFFA(1), GZMB(1), LMNB1(1), LMNB2(2) 2667353 7 6 7 3 4 0 0 0 3 0 0.853 0.990 1.000 238 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), GNAS(5), PLCE1(2), PRKACB(1), RAP2B(1) 1986577 10 6 10 3 1 0 4 2 3 0 0.743 0.991 1.000 239 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(2), ACTN2(2), BCAR1(1), CSK(1), CTNNA2(1) 2510527 7 6 7 2 1 1 5 0 0 0 0.537 0.991 1.000 240 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC2(1), PDGFRA(1), PIK3CA(1), PIK3R1(1) 1851687 4 4 4 7 0 0 1 2 1 0 1.000 0.991 1.000 241 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3(1), JAK2(2), PTPN6(1), STAT5B(1) 2458981 6 4 6 2 0 0 2 2 2 0 0.797 0.992 1.000 242 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH6(1), ADH7(2) 1841760 3 3 3 6 1 0 0 1 1 0 1.000 0.992 1.000 243 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPRU(1) 2145152 8 7 8 3 1 0 4 3 0 0 0.731 0.992 1.000 244 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(1), TYK2(2) 1737988 4 3 4 2 0 0 2 0 2 0 0.861 0.992 1.000 245 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), LAT(1), PIK3CA(1), PIK3R1(1), PTPN6(1), SYK(1), VAV1(3) 2518292 9 6 9 5 2 0 2 1 4 0 0.967 0.992 1.000 246 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(2), SELE(1), SELP(2) 2263611 9 7 9 4 2 0 4 2 0 1 0.816 0.992 1.000 247 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 BST1(2), NADSYN1(2), NMNAT3(1), NNT(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1) 2958603 11 9 10 5 1 2 5 0 3 0 0.851 0.993 1.000 248 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F5(2), PROC(1), PROS1(1), TFPI(1) 2278315 5 5 5 2 1 0 2 2 0 0 0.736 0.993 1.000 249 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), PLCG1(3) 1870779 4 4 4 4 2 0 1 0 1 0 0.970 0.993 1.000 250 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ELOVL5(2), FADS2(1), FASN(3), HADHA(1) 2137694 7 6 7 5 0 0 2 3 2 0 0.992 0.994 1.000 251 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2) 2700718 10 9 10 4 1 0 4 3 2 0 0.817 0.994 1.000 252 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP8(1), DAXX(4), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), PTPN13(2), RB1(2), RIPK2(1), SPTAN1(3) 5902753 24 16 24 5 7 2 4 2 9 0 0.440 0.994 1.000 253 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 NFKB1(1) 1288432 1 1 1 0 0 0 1 0 0 0 0.783 0.995 1.000 254 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(1), GRIN1(1), JAK2(2), NFKB1(1) 1840161 5 3 5 2 0 0 3 2 0 0 0.808 0.995 1.000 255 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CREBBP(1), EP300(2), PRKACB(1), RARA(1) 2734076 5 5 5 4 0 0 2 0 3 0 0.993 0.995 1.000 256 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY2(1), NR1D1(1), PER1(1), PER3(3) 2376080 6 4 6 2 1 0 3 0 2 0 0.751 0.996 1.000 257 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 GOT1(1), GOT2(2), GPT(1), GPT2(2), MDH2(1), ME2(1), RPIA(1) 2503494 9 8 9 4 2 1 4 0 2 0 0.813 0.996 1.000 258 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CXCR3(2), JAK2(2), TYK2(2) 2091937 7 3 7 5 1 0 1 3 2 0 0.968 0.996 1.000 259 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), HLA-DRB1(3), IL2(1), IL3(1) 1890439 6 6 6 9 0 0 4 1 1 0 1.000 0.996 1.000 260 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2), TFDP1(1) 2788890 7 7 7 3 1 0 2 2 2 0 0.807 0.997 1.000 261 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), LCT(1) 2783625 7 5 7 2 2 1 2 2 0 0 0.571 0.997 1.000 262 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(1), MAPK1(1) 1595340 3 3 3 2 0 0 1 2 0 0 0.930 0.997 1.000 263 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(2), STX18(1), STX19(1), STX7(1), TSNARE1(2), VAMP1(1), VTI1B(1) 2363181 9 9 9 4 1 0 2 4 2 0 0.858 0.997 1.000 264 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA3(1), CPS1(3), CTH(1), GLUD1(1) 2606239 6 4 6 5 1 0 2 1 2 0 0.982 0.997 1.000 265 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), ICAM1(1), ITGAL(1) 1546364 3 3 3 2 1 0 2 0 0 0 0.865 0.997 1.000 266 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(1), ITGAM(2), SELE(1) 1506647 5 5 5 3 1 0 2 2 0 0 0.892 0.997 1.000 267 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC2(1), NCKAP1(1), NTRK1(1), WASF2(1) 2112710 4 4 4 4 0 0 2 1 1 0 0.987 0.997 1.000 268 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB1(2), PSMB3(1), PSMB5(1), RPN2(2), UBE3A(1) 1818124 7 2 7 2 2 0 5 0 0 0 0.638 0.997 1.000 269 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CTLA4(2), HLA-DRB1(3), IL2(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1), PTPN11(1) 1753946 12 12 12 5 0 0 6 5 1 0 0.865 0.998 1.000 270 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(1), C2(1), C6(1), C7(1), C9(3) 2460506 7 7 7 4 1 0 3 2 1 0 0.876 0.998 1.000 271 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 11 BCAT1(2), DPYD(2), DPYS(2), PPCS(1) 1784631 7 5 7 5 1 0 2 2 2 0 0.978 0.998 1.000 272 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 CSF1(1), FCGR3A(3), IL6R(1), TNFRSF1A(1) 1935144 6 5 6 5 0 0 5 0 1 0 0.977 0.998 1.000 273 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK1(1), JAK2(2), JAK3(3), STAT5B(1), TYK2(2) 2617327 9 7 9 4 1 0 2 3 3 0 0.878 0.998 1.000 274 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 EGR2(1), EGR3(1), MAP3K1(2), NFATC1(1), NFKB1(1), PLCG1(3), PPP3CB(1), PRKACB(1), VIP(1), VIPR2(1) 3719786 13 10 13 4 3 0 7 2 1 0 0.550 0.998 1.000 275 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATP6V0C(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1) 2467374 7 7 7 3 2 0 2 3 0 0 0.746 0.998 1.000 276 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP8(1), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1) 5509460 19 15 19 5 7 1 4 0 7 0 0.559 0.998 1.000 277 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 BPNT1(3), MAPK1(1), PIK3CA(1) 2777816 5 4 5 4 0 0 1 2 1 1 0.992 0.998 1.000 278 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 12 PRKACB(1) 1658046 1 1 1 9 0 0 0 0 1 0 1.000 0.998 1.000 279 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(1), APC(4), BMPR1A(2), BMPR2(1), CHRD(2), DVL1(1), GATA4(2), MEF2C(2), NKX2-5(1), NOG(1), RFC1(1), TGFBR2(2), TGFBR3(4), WNT1(2) 4689369 26 12 26 9 2 1 12 5 6 0 0.870 0.998 1.000 280 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(4), FASN(3), OLAH(1) 2284676 10 8 10 5 1 0 5 3 1 0 0.916 0.999 1.000 281 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 EGFR(3), IGF1R(1), RB1(2), TEP1(2), TERT(1), TNKS(1) 3709722 10 9 10 5 3 1 3 0 3 0 0.845 0.999 1.000 282 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA3(1), CPS1(3), CTH(1), GLUD1(1), GLUD2(1) 2910686 7 5 7 6 2 0 2 1 2 0 0.987 0.999 1.000 283 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX5(3), PTGDS(1), PTGS1(1), PTGS2(2) 2198503 8 8 8 5 1 1 3 2 1 0 0.955 0.999 1.000 284 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 NADSYN1(2), NNT(1), NT5E(1), NT5M(1) 2010070 5 4 5 5 1 2 1 0 1 0 0.988 0.999 1.000 285 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), F2RL1(1), MAPK1(1), MAPK7(2), MYEF2(1), PLD2(1), TEC(1), VAV1(3) 3843763 11 9 10 3 2 0 6 1 2 0 0.550 0.999 1.000 286 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), GOT1(1), GOT2(2), HGD(1), MAOA(3), TH(3) 4186855 17 13 17 8 6 0 6 1 4 0 0.849 0.999 1.000 287 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(1), EP300(2), SKIL(1), TGFBR2(2) 3526782 11 10 11 6 0 0 6 2 3 0 0.983 0.999 1.000 288 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(3), MAP3K1(2), NCOR2(4), RARA(1), THRA(1) 2418457 11 9 11 5 3 0 4 3 1 0 0.873 0.999 1.000 289 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTR(1) 2438047 5 5 5 7 1 1 0 2 1 0 0.999 0.999 1.000 290 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 ITPR1(2), ITPR2(4), ITPR3(5), TF(1) 5039658 12 10 12 3 2 0 5 5 0 0 0.483 0.999 1.000 291 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(4), PIK3CA(1), PIK3R1(1) 2550593 15 13 15 5 2 1 7 3 2 0 0.768 0.999 1.000 292 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(1), FUCA2(1), GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), LCT(1), MAN2B1(1), MANBA(2) 4686147 12 7 12 3 2 2 2 5 1 0 0.546 0.999 1.000 293 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CREBBP(1), EP300(2), FADD(2), NFKB1(1), TNFRSF1A(1) 3108196 7 7 7 3 1 1 4 0 1 0 0.859 0.999 1.000 294 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(2), ETV5(2), IL18R1(2), JAK2(2), TYK2(2) 2600572 11 7 11 7 2 0 3 4 2 0 0.966 0.999 1.000 295 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(1), C2(1), C6(1), C7(1), C8B(1), C9(3) 2909219 8 8 8 4 2 0 3 2 1 0 0.813 0.999 1.000 296 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PCK1(1), SDHA(1), SDHB(1) 2856740 10 6 10 4 0 1 7 2 0 0 0.756 0.999 1.000 297 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), ESCO2(1), PNPLA3(2) 2213810 4 3 4 3 0 0 1 2 1 0 0.959 0.999 1.000 298 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH5A1(1), CAD(1), CPS1(3), EARS2(2), EPRS(4), GLUD1(1), GLUD2(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), GSS(1), NADSYN1(2), QARS(1) 5469017 24 15 24 5 4 3 7 5 5 0 0.351 0.999 1.000 299 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), JAK2(2), PLCG1(3), PTPN6(1), STAT5B(1) 3024792 8 6 8 4 2 0 2 2 2 0 0.892 0.999 1.000 300 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS3(1), LCMT1(1), WBSCR22(1) 2071361 3 3 3 5 0 1 1 0 1 0 0.995 0.999 1.000 301 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR3(1), CCR4(1), CXCR3(2), CXCR4(1), IL18R1(2), IL2(1), IL4R(1) 2800581 9 9 9 9 2 1 3 2 1 0 0.996 0.999 1.000 302 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(1), C2(1), C6(1), C7(1), C9(3) 3004149 7 7 7 5 1 0 3 2 1 0 0.929 1.000 1.000 303 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CTH(1), LCMT1(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1), WBSCR22(1) 3469989 7 6 7 7 1 1 2 1 2 0 0.995 1.000 1.000 304 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1) 2556437 6 6 6 3 2 0 1 3 0 0 0.807 1.000 1.000 305 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2) 3526621 8 6 8 3 0 0 3 2 3 0 0.835 1.000 1.000 306 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACSS2(1), FH(1), MDH2(1) 1829450 4 2 4 2 0 0 4 0 0 0 0.854 1.000 1.000 307 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1) 3213977 6 5 6 2 1 0 4 0 1 0 0.775 1.000 1.000 308 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), P4HB(1), SLC23A2(1), SLC2A3(1) 3590123 12 11 12 7 2 1 5 1 3 0 0.892 1.000 1.000 309 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), EPN1(1), PICALM(1), PPP3CB(1), SYNJ1(1) 3143364 6 6 6 3 0 0 6 0 0 0 0.844 1.000 1.000 310 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 15 BCAT1(2), BCAT2(1), DPYD(2), DPYS(2), PPCS(1), VNN1(1) 2261960 9 6 9 6 1 0 4 2 2 0 0.975 1.000 1.000 311 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), NDST2(1), NDST4(2) 2898605 13 8 13 8 1 0 6 4 2 0 0.960 1.000 1.000 312 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(1), EP300(2), NCOA1(2), NCOA2(1) 2512629 6 6 6 3 0 0 4 1 1 0 0.933 1.000 1.000 313 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(1) 2009600 1 1 1 1 0 0 1 0 0 0 0.949 1.000 1.000 314 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP5(1), ACP6(1), ACPP(1), ALPI(1), ALPP(1), DHRS3(1), PON1(1) 2401890 7 7 7 7 0 1 3 2 1 0 0.991 1.000 1.000 315 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPN11(1), SRF(1) 3326361 10 8 10 4 2 0 3 4 1 0 0.827 1.000 1.000 316 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPN2(3), CAPNS1(1), EP300(2), HDAC1(1), HDAC2(1), NFATC1(1), PPP3CB(1) 3333216 11 10 11 6 1 0 7 1 2 0 0.911 1.000 1.000 317 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2L1(2), CASP8(1), DAXX(4), DFFA(1), FADD(2), NFKB1(1), NGFR(2), NTRK1(1), PTPN13(2), TNFRSF1A(1) 6064508 18 14 18 9 5 2 3 2 6 0 0.951 1.000 1.000 318 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IL2(1), MAP3K1(2), NFKB1(1), TNFSF9(2) 2736643 6 5 6 3 2 0 4 0 0 0 0.868 1.000 1.000 319 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 12 APC(4), CREBBP(1), DVL1(1), EP300(2), HDAC1(1), LDB1(1), PITX2(3), TRRAP(1), WNT1(2) 4201229 16 10 16 5 3 0 8 1 4 0 0.758 1.000 1.000 320 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(1), LARS(1), LARS2(1), PDHB(1), VARS(8), VARS2(1) 2555249 16 14 11 6 1 0 10 3 2 0 0.816 1.000 1.000 321 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C6(1), C7(1), ICAM1(1), ITGA4(2), ITGAL(1), SELP(2) 3419466 8 7 8 5 2 0 5 0 0 1 0.913 1.000 1.000 322 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(2), EMR1(1), EMR2(4), GIPR(1), GLP1R(1), GPR64(1), LPHN1(3), LPHN2(1), LPHN3(3), VIPR1(1), VIPR2(1) 3879806 24 17 23 9 3 1 13 5 2 0 0.689 1.000 1.000 323 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(4), CREBBP(1), DVL1(1), HDAC1(1), WIF1(1), WNT1(2) 3813555 10 8 10 6 0 0 6 1 3 0 0.984 1.000 1.000 324 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH5A1(1), ECHS1(2), EHHADH(1), HADHA(1), OXCT1(1), PDHB(1), SDHB(1), SDS(1) 3555205 10 7 10 5 1 0 4 3 2 0 0.907 1.000 1.000 325 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 GMPPB(1), HK2(3), HK3(3), KHK(2) 3372319 9 9 9 4 2 0 5 1 1 0 0.728 1.000 1.000 326 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 AOC3(1), MAOA(3) 3408979 4 3 4 4 1 0 1 0 2 0 0.986 1.000 1.000 327 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(4), EGFR(3), ETS2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), TNFRSF1A(1) 6585044 19 17 19 7 3 1 6 3 6 0 0.812 1.000 1.000 328 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(2), JAK2(2), MAP3K1(2), PIK3CA(1), PIK3R1(1), STAT5B(1) 3803845 9 7 9 6 1 0 3 3 2 0 0.985 1.000 1.000 329 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 3975922 10 8 10 6 3 0 4 0 3 0 0.921 1.000 1.000 330 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), ZAP70(1) 3110180 17 12 17 6 1 0 9 3 4 0 0.779 1.000 1.000 331 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), ZAP70(1) 3110180 17 12 17 6 1 0 9 3 4 0 0.779 1.000 1.000 332 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), CDIPT(1), CHAT(1), CHKB(1), CHPT1(2), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), ESCO2(1), GNPAT(1), GPAM(3), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PNPLA3(2), PPAP2C(1) 9300413 35 20 33 8 5 1 15 9 5 0 0.309 1.000 1.000 333 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 GNB1(2), MAPK1(1), PLA2G4A(3), PLCB1(3), PTGS1(1), SYK(1) 3340399 11 8 11 6 1 0 6 3 1 0 0.939 1.000 1.000 334 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 CYP2C9(1), DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2) 4221008 9 6 9 4 0 0 4 2 3 0 0.876 1.000 1.000 335 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(1), EP300(2), JAK1(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5B(1) 3859213 11 10 11 5 1 0 5 2 3 0 0.907 1.000 1.000 336 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2(1), JAK1(1), JAK3(3), LCK(1), STAT5B(1), SYK(1) 3289015 8 7 8 4 1 0 4 1 2 0 0.883 1.000 1.000 337 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAS(5), GNB1(2), MAPK1(1), NOX1(1), PIK3C2G(1), PLCB1(3) 3541354 15 13 15 7 2 0 6 5 2 0 0.917 1.000 1.000 338 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), FUT3(3), FUT4(1), FUT6(2), GBGT1(2), GCNT2(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1) 6846359 23 13 23 5 5 0 9 5 4 0 0.378 1.000 1.000 339 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 43 AGXT(2), AOC3(1), CHKB(1), CTH(1), DAO(2), GCAT(2), MAOA(3), PEMT(1), PIPOX(1), SARDH(1), SDS(1), SHMT2(1) 5750728 17 13 16 8 5 1 4 3 4 0 0.893 1.000 1.000 340 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 BCL2L1(2), H2AFX(1), NFKB1(1), PIK3CA(1), PIK3R1(1) 2725551 6 5 6 3 1 0 3 1 1 0 0.895 1.000 1.000 341 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT5(2), MGAT3(1), RPN2(2) 2794751 6 4 6 3 2 0 2 2 0 0 0.874 1.000 1.000 342 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN2(2), CAPNS1(1), SPTAN1(3), TLN1(2) 4026477 10 8 10 4 4 1 4 0 1 0 0.652 1.000 1.000 343 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDHPPT(1), ATP6V0C(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), HADHA(1), PLOD3(2), SDS(1), SHMT2(1) 5069325 18 11 18 7 3 2 8 1 4 0 0.772 1.000 1.000 344 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F5(2), F8(2), F9(1), LPA(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1), VWF(6) 4810164 16 12 16 8 2 1 6 4 3 0 0.896 1.000 1.000 345 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ARRB2(1), CALML3(1), CALML6(1), GNAL(2), PDE1C(1), PRKACA(1), PRKACB(1), PRKG2(2) 4285561 10 9 10 7 2 0 3 3 2 0 0.985 1.000 1.000 346 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(2), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1), SDS(1) 4517530 13 11 13 5 3 0 7 1 2 0 0.789 1.000 1.000 347 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(1), BCL2L1(2), CSF2RB(1), IGF1R(1), IL3(1), PIK3CA(1), PIK3R1(1), PRKACB(1) 2912720 9 7 9 5 2 0 3 2 2 0 0.930 1.000 1.000 348 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JAK2(2), MPL(1), PIK3CA(1), PIK3R1(1), PLCG1(3), STAT5B(1) 4100194 9 7 9 6 2 0 2 3 2 0 0.985 1.000 1.000 349 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 AOC3(1), EPX(1), ESCO2(1), GOT1(1), GOT2(2), MAOA(3), MIF(3), PNPLA3(2) 4457359 14 11 13 6 4 0 6 2 2 0 0.839 1.000 1.000 350 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(1), DUSP1(1), EP300(2), MAP2K3(2), MAPK11(1), NFKB1(1), TGFBR2(2), TLR2(2) 4095385 12 8 12 6 0 0 7 3 2 0 0.956 1.000 1.000 351 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 17 ABCA1(1), HMGCR(1), LDLR(1), LRP1(7), SCARB1(3) 3737686 13 10 12 6 4 0 5 3 1 0 0.806 1.000 1.000 352 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4) 4520468 13 10 13 5 1 0 8 2 2 0 0.730 1.000 1.000 353 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 EIF4G1(1), EIF4G3(1), MAPK1(1), MKNK1(1), PIK3CA(1), PIK3R1(1) 3647795 6 6 6 6 1 0 1 3 1 0 0.994 1.000 1.000 354 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2L1(2), CBL(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN6(1), STAT5B(1), SYK(1) 4999893 13 11 13 8 2 1 4 3 3 0 0.975 1.000 1.000 355 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 CMA1(1), COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4) 3550610 10 9 10 6 2 1 5 1 1 0 0.890 1.000 1.000 356 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 20 EPRS(4), FARS2(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(1), WARS2(1) 4163969 13 8 13 4 2 1 3 5 2 0 0.690 1.000 1.000 357 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), MAP3K1(2), NFATC1(1), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3) 5234076 12 7 12 4 5 0 5 0 2 0 0.640 1.000 1.000 358 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), MAPK1(1), MAPK8IP3(2) 3966704 7 4 7 5 0 0 4 2 1 0 0.971 1.000 1.000 359 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPN2(3), CAPNS1(1), CXCR3(2), EGFR(3), MAPK1(1), MYLK(2), PRKACB(1), TLN1(2) 4526358 15 11 15 9 5 0 6 2 2 0 0.928 1.000 1.000 360 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), CASP8(1), DFFA(1), FADD(2), NFKB1(1), SPTAN1(3), TNFRSF10A(1) 4658136 10 8 10 8 4 1 3 0 2 0 0.983 1.000 1.000 361 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 BTK(1), EEA1(2), PFKL(2), PLCG1(3), VAV2(1) 3332566 9 8 9 5 3 0 3 2 1 0 0.877 1.000 1.000 362 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACSL1(3), ACSL3(2), ADH6(1), ADH7(2), CPT1C(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(3) 6605074 18 13 18 8 3 1 7 3 4 0 0.888 1.000 1.000 363 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4G1(1), EIF4G3(1), MKNK1(1), PIK3CA(1), PIK3R1(1), TSC2(1) 3813275 6 6 6 6 1 0 2 2 1 0 0.995 1.000 1.000 364 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(1), ADSL(1), ADSS(1), ADSSL1(3), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), PC(1), PDHB(1) 5283699 18 15 17 6 5 2 6 3 2 0 0.669 1.000 1.000 365 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLK(1), POLM(1), POLQ(1), REV3L(1), RFC5(1) 5699953 13 9 12 4 1 1 6 3 2 0 0.778 1.000 1.000 366 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 IARS(1), IL13RA1(1), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(1), SERPINA4(1), SOS2(1), STAT6(1), TYK2(2) 5108518 16 10 16 8 1 1 4 7 3 0 0.928 1.000 1.000 367 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), NOS1(2), PPP3CB(1), PRKACB(1) 3495740 10 7 10 9 4 0 4 1 1 0 0.989 1.000 1.000 368 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), OGT(1), ST3GAL1(1), ST6GALNAC1(1) 4440175 16 11 16 5 3 1 5 4 3 0 0.683 1.000 1.000 369 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 APC(4), DACT1(3), DKK1(1), DKK2(1), DVL1(1), LRP1(7), NKD1(1), NKD2(1), PIN1(1), PTPRA(1), WIF1(1) 5482955 22 14 22 8 6 1 8 5 2 0 0.735 1.000 1.000 370 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), CDT1(1), DIAPH2(2), MCM3(1), NACA(4), POLA2(1), POLD1(2), POLD2(1), POLE(3), RFC1(1), RFC5(1), RPA2(1), RPA4(1), UBB(1) 6914128 21 14 20 6 3 1 7 7 3 0 0.680 1.000 1.000 371 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), MAN2A1(2), MGAT3(1), RPN2(2) 5937431 13 11 13 6 2 0 6 2 3 0 0.844 1.000 1.000 372 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(1), GNAS(5), GNB1(2), NFATC1(1), PLCG1(3), PPP3CB(1), PRKACB(1) 4729780 14 11 14 6 3 0 6 2 3 0 0.840 1.000 1.000 373 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC2(1), GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4), PFKL(2), UGP2(1) 5366229 17 11 17 7 2 0 9 4 2 0 0.780 1.000 1.000 374 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AFMID(1), AOC3(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), KMO(1), LCMT1(1), LNX1(2), MAOA(3), OGDHL(1), TDO2(1), WARS2(1), WBSCR22(1) 8371686 21 14 21 6 2 1 11 3 4 0 0.563 1.000 1.000 375 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ALDH5A1(1), DDHD1(3), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), OXCT1(1), PDHB(1) 5682444 16 11 15 6 2 0 8 4 2 0 0.777 1.000 1.000 376 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(4), ACSS2(1), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1) 6409806 17 13 17 9 3 1 8 3 2 0 0.943 1.000 1.000 377 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(4), AR(2), BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PHKA2(2), PIK3CA(1), PIK3R1(1), PITX2(3), PTX3(1) 7502620 30 20 30 9 5 0 13 10 2 0 0.581 1.000 1.000 378 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1) 5063227 12 11 12 9 3 1 5 2 1 0 0.984 1.000 1.000 379 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(2), MAP3K1(2), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PLA2G4A(3), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3) 5895332 20 11 20 6 5 0 9 3 3 0 0.661 1.000 1.000 380 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN2(2), BCAR1(1), BCR(2), CAPNS1(1), CSK(1), MAPK1(1), ROCK1(2), TLN1(2), ZYX(1) 6609163 15 12 15 7 3 1 8 1 2 0 0.830 1.000 1.000 381 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), BLVRA(1), CP(1), EARS2(2), EPRS(4), GUSB(1), MMAB(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 5740798 25 15 24 7 4 0 14 6 1 0 0.518 1.000 1.000 382 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 MAP3K1(2), MYLK(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), TRIO(1), VAV1(3) 4827775 11 9 11 9 4 0 4 2 1 0 0.993 1.000 1.000 383 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF2(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF4G1(1), EIF4G3(1), PABPC3(3), PAIP1(1) 5950694 11 7 11 7 1 0 4 4 2 0 0.971 1.000 1.000 384 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), CDC16(2), CDC20(1), CDC27(1), CUL3(1), FZR1(2), ITCH(1), WWP1(1), WWP2(1) 5590738 11 9 11 6 1 0 3 6 1 0 0.949 1.000 1.000 385 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 GSN(1), MAPK1(1), MYLK(2), PIK3CA(1), PIK3R1(1), ROCK1(2), TLN1(2) 5177005 10 9 10 7 1 0 6 2 1 0 0.974 1.000 1.000 386 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), LAT(1), LCK(1), MAP3K1(2), NFATC1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PPP3CB(1), PTPN7(1), VAV1(3), ZAP70(1) 6601248 18 11 18 6 5 0 9 1 3 0 0.687 1.000 1.000 387 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ITGA9(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), SGCB(1), VASP(1) 6858282 21 15 21 7 2 0 11 7 1 0 0.656 1.000 1.000 388 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), F5(2), F8(2), F9(1), PROC(1), PROS1(1), SERPING1(1) 6224911 17 14 17 9 2 1 8 5 1 0 0.912 1.000 1.000 389 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(2), GAB1(1), HGF(1), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN11(1) 6270544 8 7 8 9 0 1 3 3 1 0 0.999 1.000 1.000 390 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 GAB1(1), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAPK7(2), MYEF2(1), NR2C2(1), PAPPA(6) 6819952 17 12 16 8 3 2 10 1 1 0 0.875 1.000 1.000 391 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 CAMK4(1), CREBBP(1), GATA4(2), LIF(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NKX2-5(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), PRKACB(1) 6825203 16 8 16 7 0 1 9 5 1 0 0.878 1.000 1.000 392 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(5), ATR(3), CASP8(1), CCNB3(2), CCND2(1), CDKN2A(2), CHEK2(2), DDB2(1), GADD45G(2), GTSE1(1), IGFBP3(1), MDM2(2), PMAIP1(1), RRM2(1), SERPINE1(1), SESN1(1), THBS1(1), TP53I3(1), TP73(1), TSC2(1) 8994024 32 23 32 10 4 0 10 5 13 0 0.808 1.000 1.000 393 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(1), ARRB1(1), ARRB2(1), ATF4(1), BDNF(1), BRAF(1), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(3), CACNA2D1(2), CACNA2D4(4), CACNB3(1), CACNB4(1), CACNG3(1), CACNG6(1), CACNG7(1), CD14(1), DAXX(4), DUSP1(1), DUSP6(1), DUSP7(3), ECSIT(1), EGFR(3), ELK4(1), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(2), FGF5(1), FGFR2(2), FGFR4(1), FLNA(3), FLNB(1), FLNC(1), GADD45G(2), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MAPK8IP3(2), MEF2C(2), MKNK1(1), NFKB1(1), NFKB2(1), NR4A1(1), NRAS(1), NTF3(1), NTRK1(1), NTRK2(1), PDGFRA(1), PDGFRB(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PPP3CB(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKCG(1), PTPN7(1), RAPGEF2(2), RASGRF1(2), RASGRF2(1), RASGRP1(2), RPS6KA1(1), RPS6KA4(2), RPS6KA6(1), SOS2(1), SRF(1), STK4(1), TAOK1(2), TAOK2(6), TAOK3(2), TGFBR2(2), TNFRSF1A(1) 40485022 157 59 148 94 30 10 69 24 24 0 1.000 1.000 1.000 394 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 191 ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), BRAF(1), CAPN2(3), CCND2(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), DOCK1(2), EGFR(3), FARP2(1), FLNA(3), FLNB(1), FLNC(1), FN1(1), HGF(1), IGF1R(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), KDR(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), MAPK1(1), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), PRKCG(1), RAPGEF1(1), RELN(7), ROCK1(2), SHC2(2), SHC3(1), SOS2(1), THBS1(1), THBS2(2), THBS4(2), TLN1(2), TLN2(6), TNC(3), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(1), VAV3(3), VEGFB(1), VTN(1), VWF(6), ZYX(1) 52120862 186 59 186 77 39 11 79 30 26 1 0.972 1.000 1.000 395 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTG1(2), COL11A1(1), COL17A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), DES(1), DSC2(3), DSC3(2), DSG1(3), DSG2(1), DSG3(2), DSG4(1), FN1(1), GJA1(2), GJA4(1), GJA8(1), GJB2(1), GJD3(1), GJD4(1), INA(1), ITGA6(1), ITGB4(1), KRT1(2), KRT12(2), KRT14(2), KRT17(1), KRT2(2), KRT20(1), KRT31(1), KRT32(3), KRT33A(1), KRT33B(3), KRT36(1), KRT39(2), KRT40(1), KRT6A(1), KRT71(1), KRT72(2), KRT73(1), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(1), KRT81(1), KRT83(2), KRT84(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), LMNB1(1), LMNB2(2), NES(1), RELN(7), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VIM(1), VTN(1), VWF(6) 35044362 161 57 158 77 44 9 70 21 17 0 0.994 1.000 1.000 396 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(1), ADCY2(3), ADCY4(1), ADCY7(1), ADCY8(3), ATP2A1(2), ATP2A2(2), ATP2A3(1), ATP2B3(4), AVPR1A(3), AVPR1B(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(3), CALML3(1), CALML6(1), CAMK4(1), CHRM5(1), CYSLTR2(1), EDNRB(1), EGFR(3), ERBB3(1), ERBB4(5), GNAL(2), GNAS(5), GRIN1(1), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), NOS1(2), NOS3(4), P2RX5(1), PDE1A(2), PDE1C(1), PDGFRA(1), PDGFRB(1), PHKA2(2), PHKB(3), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A2(2), SLC8A3(1), SPHK1(2), SPHK2(2), TACR3(1), TBXA2R(1), TRPC1(1) 38934905 176 56 167 98 40 10 75 30 21 0 1.000 1.000 1.000 397 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADRA2A(2), ADRA2B(1), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CALCR(1), CALCRL(1), CHRM5(1), CYSLTR2(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GABBR1(2), GABRA1(2), GABRA2(2), GABRA6(2), GABRB1(1), GABRB2(1), GABRB3(2), GABRD(1), GABRE(1), GABRG1(1), GABRG2(3), GABRG3(1), GABRR2(1), GALR3(1), GH2(1), GIPR(1), GLP1R(1), GLRA1(3), GLRB(1), GPR156(1), GPR50(4), GPR83(1), GRIA2(3), GRID1(1), GRID2(1), GRIK1(3), GRIK2(2), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRIN3A(4), GRIN3B(7), GRM1(3), GRM3(4), GRM4(1), GRM5(1), GRM6(1), GRM8(4), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), KISS1R(3), LEPR(2), MC1R(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(2), NPBWR2(1), NPFFR2(1), NPY1R(1), OPRL1(1), P2RX5(1), P2RY14(1), P2RY2(2), P2RY4(1), PARD3(1), PPYR1(3), PRLHR(2), PRSS1(1), PRSS3(1), PTGER4(1), PTGIR(1), RXFP1(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TAAR5(4), TACR3(1), TBXA2R(1), THRA(1), TRPV1(1), VIPR1(1), VIPR2(1) 30606842 162 52 154 115 28 5 80 37 12 0 1.000 1.000 1.000 398 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), FN1(1), FNDC1(4), GP6(2), GP9(2), HMMR(1), HSPG2(6), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), RELN(7), SDC1(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VTN(1), VWF(6) 31935819 126 50 124 47 26 8 56 23 12 1 0.798 1.000 1.000 399 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(2), ACTN2(2), ACTN4(1), APC(4), APC2(2), ARHGEF1(1), ARHGEF4(2), ARPC2(1), BCAR1(1), BDKRB2(1), BRAF(1), CD14(1), CHRM5(1), CSK(1), CYFIP1(1), CYFIP2(3), DIAPH2(2), DIAPH3(1), DOCK1(2), EGFR(3), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(2), FGF5(1), FGFR2(2), FGFR4(1), FN1(1), GIT1(1), GSN(1), IQGAP2(1), IQGAP3(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LIMK2(1), MAPK1(1), MYH14(3), MYLK(2), MYLK2(2), NCKAP1(1), NRAS(1), PAK3(3), PAK4(1), PAK7(2), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), ROCK1(2), SCIN(1), SLC9A1(1), SOS2(1), SSH1(1), TIAM1(4), TIAM2(3), VAV1(3), VAV2(1), VAV3(3), WAS(1), WASF2(1) 39316248 124 48 122 58 18 7 55 24 19 1 0.996 1.000 1.000 400 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ARRB1(1), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP2A2(2), ATP2A3(1), ATP2B3(4), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1S(3), CACNB3(1), CAMK4(1), CHRM5(1), GJA1(2), GJA4(1), GJB2(1), GNB1(2), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(5), KCNB1(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A3(1), YWHAQ(1) 26775131 111 47 102 64 20 11 50 16 14 0 1.000 1.000 1.000 401 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSL(1), ADSS(1), ADSSL1(3), AK5(2), ENTPD2(1), ENTPD4(3), ENTPD8(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(2), PAPSS2(1), PDE10A(1), PDE1A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PDE9A(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), PRPS1L1(1), RFC5(1), RRM2(1), XDH(3) 22918465 77 44 74 35 11 6 36 17 7 0 0.979 1.000 1.000 402 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(1), ACVR1B(1), ACVR2B(1), AMH(1), AMHR2(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CCL11(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CNTFR(1), CSF1(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL14(1), CXCL3(1), CXCL9(2), CXCR3(2), CXCR4(1), EGFR(3), EPO(1), FLT3(1), FLT4(6), GDF5(1), GH2(1), HGF(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL17A(1), IL17RA(2), IL18R1(2), IL2(1), IL21R(2), IL23R(1), IL24(1), IL25(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), INHBA(2), INHBB(3), KDR(1), LEPR(2), LIF(1), MPL(1), NGFR(2), OSMR(4), PDGFRA(1), PDGFRB(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11A(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF6B(1), TNFSF11(1), TNFSF9(2), VEGFB(1), XCL1(1) 24496592 97 42 96 44 23 5 41 14 14 0 0.960 1.000 1.000 403 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABLIM1(2), ABLIM2(1), ABLIM3(3), CXCR4(1), DCC(1), EFNA2(1), EPHA1(2), EPHA2(1), EPHA5(2), EPHA6(2), EPHA8(3), EPHB1(1), EPHB3(2), EPHB4(2), EPHB6(1), L1CAM(1), LIMK2(1), LRRC4C(3), MAPK1(1), NCK2(1), NFATC1(1), NRAS(1), NTN1(1), NTN4(2), NTNG1(2), PAK3(3), PAK4(1), PAK7(2), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB2(3), PLXNB3(7), PLXNC1(1), PPP3CB(1), RGS3(1), RHOD(2), RND1(1), ROBO1(3), ROBO2(4), ROBO3(1), ROCK1(2), SEMA3D(3), SEMA3E(1), SEMA3F(1), SEMA3G(2), SEMA4F(1), SEMA4G(1), SEMA5A(3), SEMA6A(2), SEMA6B(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT2(6), UNC5A(2), UNC5B(1), UNC5C(3), UNC5D(2) 27524944 115 41 113 45 29 9 57 11 9 0 0.748 1.000 1.000 404 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 CADM1(1), CADM3(2), CD276(1), CD8A(1), CD99(1), CDH1(1), CDH2(3), CDH3(1), CDH4(4), CDH5(2), CLDN1(1), CLDN5(3), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(1), CTLA4(2), ESAM(1), F11R(2), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), ICAM1(1), ITGA4(2), ITGA6(1), ITGA9(1), ITGAL(1), ITGAM(2), ITGB8(2), L1CAM(1), MAG(1), NFASC(1), NLGN1(1), NLGN2(4), NRCAM(2), NRXN1(3), NRXN2(3), PTPRF(2), PVR(1), PVRL1(2), PVRL3(2), SDC1(1), SDC4(1), SELE(1), SELP(2), VCAN(4) 20373575 87 41 85 61 19 2 40 19 6 1 1.000 1.000 1.000 405 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADM(1), ARRB1(1), ARRB2(1), ATF4(1), ATP2A2(2), ATP2A3(1), CACNB3(1), CALCA(1), CNN1(1), CORIN(1), DGKZ(6), ETS2(1), GABPB2(1), GJA1(2), GNB1(2), GRK4(1), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK2(2), NFKB1(1), NOS1(2), NOS3(4), PDE4B(1), PDE4D(1), PLCB3(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKCH(1), PRKCQ(2), PRKD1(1), RAMP3(2), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), TNXB(3), YWHAQ(1) 24544947 107 41 104 70 16 8 50 22 11 0 1.000 1.000 1.000 406 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), EGFR(3), GJA1(2), GNAS(5), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), MAPK7(2), NRAS(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKG2(2), SOS2(1), TJP1(1), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1) 18527419 71 40 69 37 15 1 28 17 10 0 0.991 1.000 1.000 407 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), ASH1L(1), CLDN1(1), CLDN5(3), CLDN9(1), CSDA(1), CTNNA2(1), CTNNA3(1), EPB41(1), EPB41L1(1), EPB41L3(1), EXOC3(1), F11R(2), INADL(1), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(2), MPDZ(4), MPP5(1), MYH11(2), MYH13(1), MYH14(3), MYH15(3), MYH2(2), MYH3(2), MYH4(3), MYH6(4), MYH7(1), MYH8(4), NRAS(1), PARD3(1), PPP2R1B(1), PPP2R3A(2), PPP2R3B(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), SPTAN1(3), SYMPK(2), TJAP1(1), TJP1(1), TJP2(1), TJP3(3), VAPA(1) 26707845 86 39 83 38 20 7 35 15 9 0 0.948 1.000 1.000 408 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSL(1), ADSS(1), AK5(2), ATP1B1(1), ATP5F1(1), ENTPD2(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NT5E(1), NT5M(1), NUDT2(1), PAPSS2(1), PDE1A(2), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE9A(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), PRPS1L1(1), RRM2(1) 17959345 59 39 54 30 10 9 23 12 5 0 0.989 1.000 1.000 409 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 89 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), AKAP1(2), AKAP11(1), AKAP12(4), AKAP4(2), AKAP5(1), AKAP6(1), AKAP8(2), AKAP9(3), ARHGEF1(1), GNAL(2), GNB1(2), ITPR1(2), NRAS(1), PDE1A(2), PDE1C(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PLCB3(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), SLC9A1(1) 15850291 57 37 56 31 8 1 26 12 10 0 0.998 1.000 1.000 410 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(10), CACNA1B(6), GNAS(5), GNB1(2), GRM4(1), ITPR3(5), KCNB1(1), PDE1A(2), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1B(2), TAS1R2(1), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R42(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R50(1) 8148492 58 37 51 27 8 6 34 5 5 0 0.946 1.000 1.000 411 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(10), GNAS(5), GRIA2(3), GRID2(1), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IGF1R(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NOS1(2), NOS3(4), NRAS(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PRKCG(1), PRKG2(2), RYR1(4) 15662151 70 36 67 47 10 1 32 18 9 0 1.000 1.000 1.000 412 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(3), CACNA1S(3), CALML3(1), CALML6(1), EGFR(3), GNAS(5), ITPR1(2), ITPR2(4), ITPR3(5), MAP2K3(2), MAP3K1(2), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MMP14(2), NRAS(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PLD2(1), PRKACA(1), PRKACB(1), SOS2(1) 18256392 74 36 70 31 16 1 30 14 13 0 0.935 1.000 1.000 413 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADRA2A(2), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CHRM5(1), CX3CR1(2), CXCR3(2), CXCR4(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GALR3(1), GPR173(2), GPR174(1), GPR3(1), GPR37(1), GPR4(3), GPR50(4), GPR6(1), GPR83(1), GPR85(1), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), MC1R(1), MC3R(1), MTNR1A(2), MTNR1B(2), NPY1R(1), OPRL1(1), OR2H1(1), OR7A5(1), P2RY12(1), P2RY14(1), P2RY2(2), PPYR1(3), PTGER4(1), PTGIR(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), SUCNR1(1), TBXA2R(1) 16555461 82 35 78 70 17 3 38 19 5 0 1.000 1.000 1.000 414 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(2), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC3(1), G6PC2(1), GAA(1), GUSB(1), HK2(3), HK3(3), LYZL1(2), MGAM(4), MOV10L1(1), PYGL(1), RAD54B(1), RUVBL2(1), SETX(2), SI(5), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 16964957 60 32 58 25 4 1 29 12 13 1 0.978 1.000 1.000 415 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), CALML3(1), CALML6(1), CREB3L1(1), CREB3L3(2), CREBBP(1), DCT(1), DVL1(1), DVL2(1), EDNRB(1), EP300(2), FZD5(1), FZD7(1), FZD8(2), GNAS(5), MAPK1(1), MC1R(1), NRAS(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), TCF7L2(1), TYRP1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 14897099 56 32 55 33 9 2 23 10 11 1 0.999 1.000 1.000 416 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(4), APC2(2), CCND2(1), CHD8(1), CREBBP(1), CTBP2(4), DAAM1(2), DAAM2(2), DKK1(1), DKK2(1), DVL1(1), DVL2(1), EP300(2), FZD5(1), FZD7(1), FZD8(2), LRP6(1), NFATC1(1), NKD1(1), NKD2(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PPP3CB(1), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCG(1), ROCK1(2), TBL1X(3), TCF7L2(1), WIF1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 21943747 58 30 57 44 9 3 21 11 13 1 1.000 1.000 1.000 417 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 BCL2L1(2), CBL(1), CBLC(1), CCND2(1), CNTFR(1), CREBBP(1), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(2), EPO(1), GH2(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL2(1), IL21R(2), IL23R(1), IL24(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), LIF(1), MPL(1), OSMR(4), PIAS2(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PTPN11(1), PTPN6(1), SOCS5(1), SOCS7(1), SOS2(1), SPRED1(1), STAM(1), STAT5B(1), STAT6(1), TYK2(2) 19960276 64 30 64 23 5 4 26 12 17 0 0.906 1.000 1.000 418 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(3), ATF4(1), BRAF(1), CACNA1C(1), CALML3(1), CALML6(1), CAMK4(1), CREBBP(1), EP300(2), GRIA2(3), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NRAS(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP1CA(2), PPP1R12A(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1) 14248219 54 29 53 35 10 1 19 13 11 0 1.000 1.000 1.000 419 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(1), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(2), FBXO11(1), HCFC1(2), MLL(5), MLL2(4), MLL3(7), MLL4(8), MLL5(1), NSD1(4), OGT(1), PPP1CA(2), PRDM6(2), PRDM9(5), SETD1A(1), SETD1B(2), SETD2(3), SETDB1(1), SETDB2(1), SETMAR(1), SUV420H1(1), WHSC1(1), WHSC1L1(1) 17316336 64 28 64 20 12 2 21 10 18 1 0.792 1.000 1.000 420 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), COX4I1(1), COX4I2(1), COX6B1(1), COX7A1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(1), NDUFB10(1), NDUFB11(2), NDUFB5(2), NDUFB7(1), NDUFB8(1), NDUFS2(1), PPA1(1), SDHA(1), SDHB(1), SDHD(1), TCIRG1(1), UQCRFS1(12) 7869869 45 28 33 17 4 2 15 18 6 0 0.898 1.000 1.000 421 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), CD99(1), CDH5(2), CLDN1(1), CLDN5(3), CLDN9(1), CTNNA2(1), CTNNA3(1), CXCR4(1), ESAM(1), F11R(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(2), ITK(1), MAPK11(1), MMP9(1), NOX1(1), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), PTPN11(1), RAPGEF3(1), RASSF5(3), ROCK1(2), VASP(1), VAV1(3), VAV2(1), VAV3(3) 17245035 57 28 57 27 12 2 22 11 9 1 0.971 1.000 1.000 422 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(1), CAPN2(3), CAPN6(4), CAPN9(1), CAPNS1(1), CSK(1), DOCK1(2), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), MAP2K3(2), MAPK7(2), MYLK2(2), PAK3(3), PAK4(1), PIK3R2(1), RAPGEF1(1), ROCK1(2), SHC3(1), SORBS1(1), TLN1(2), TNS1(3), VASP(1), VAV2(1), VAV3(3), ZYX(1) 19075816 60 28 59 22 9 0 34 10 6 1 0.750 1.000 1.000 423 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(1), ACVR1B(1), ACVRL1(1), AURKB(1), BMPR1A(2), BMPR2(1), CDIPT(1), CLK1(2), CLK2(1), COL4A3BP(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), INPP4A(2), NEK1(1), OCRL(1), PAK4(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RPS6KA1(1), RPS6KA4(2), STK11(2) 15871696 50 28 48 41 11 2 15 13 9 0 1.000 1.000 1.000 424 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(1), CALML6(1), CDIPT(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), INPP4A(2), INPP5B(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), OCRL(1), PI4KA(4), PIK3C2G(1), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PRKCG(1), SYNJ1(1) 17732023 57 27 55 36 10 1 22 18 6 0 1.000 1.000 1.000 425 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC10(1), ATM(5), ATR(3), CCNB3(2), CCND2(1), CDC14A(1), CDC16(2), CDC20(1), CDC27(1), CDC7(1), CDKN2A(2), CHEK2(2), CREBBP(1), DBF4(3), E2F3(1), EP300(2), ESPL1(1), FZR1(2), GADD45G(2), HDAC1(1), HDAC2(1), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), PRKDC(3), RB1(2), RBL1(1), SMC1A(2), TFDP1(1), YWHAQ(1) 18706708 51 27 51 26 9 3 16 5 18 0 0.998 1.000 1.000 426 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(1), CTBP2(4), DLL1(1), DLL3(1), DTX2(2), DTX4(1), DVL1(1), DVL2(1), EP300(2), HDAC1(1), HDAC2(1), JAG2(1), MAML1(1), MAML3(2), NCOR2(4), NOTCH1(4), NOTCH3(3), NOTCH4(2), PTCRA(2), RBPJL(2), SNW1(2) 9370365 39 27 37 33 7 3 15 7 7 0 1.000 1.000 1.000 427 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(1), ABCA12(3), ABCA13(3), ABCA2(2), ABCA3(1), ABCA5(2), ABCA6(3), ABCA7(2), ABCB1(1), ABCB11(1), ABCB4(2), ABCB5(1), ABCC1(1), ABCC10(1), ABCC11(4), ABCC12(1), ABCC2(2), ABCC3(2), ABCC5(1), ABCC6(2), ABCC9(1), ABCD1(1), ABCD2(1), ABCD4(1), ABCG5(1), CFTR(2), TAP1(1), TAP2(1) 16652984 45 26 45 47 7 2 19 6 11 0 1.000 1.000 1.000 428 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), APAF1(1), ATM(5), BCL2L1(2), CAPN2(3), CASP8(1), CSF2RB(1), DFFA(1), FADD(2), IL3(1), IRAK1(2), IRAK2(2), NFKB1(1), NFKB2(1), NTRK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PRKACA(1), PRKACB(1), TNFRSF10A(1), TNFRSF1A(1) 11477292 37 25 36 37 5 2 15 5 10 0 1.000 1.000 1.000 429 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(1), ACVR2B(1), ACVRL1(1), AMH(1), AMHR2(1), BMP6(1), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CHRD(2), CREBBP(1), DCN(2), EP300(2), GDF5(1), GDF6(1), ID1(1), INHBA(2), INHBB(3), LEFTY2(1), LTBP1(1), MAPK1(1), NOG(1), PITX2(3), PPP2R1B(1), RBL1(1), ROCK1(2), SMAD6(1), SMAD7(1), TFDP1(1), TGFBR2(2), THBS1(1), THBS2(2), THBS4(2), ZFYVE16(1), ZFYVE9(3) 13557823 52 25 52 30 15 2 23 10 2 0 0.995 1.000 1.000 430 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 BDKRB2(1), C1QC(1), C1S(1), C2(1), C3AR1(1), C6(1), C7(1), C8B(1), C9(3), CFB(1), CFD(1), CFH(2), CR1(1), CR2(2), F13A1(1), F5(2), F8(2), F9(1), KNG1(1), PLAT(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPING1(1), TFPI(1), VWF(6) 12597142 40 25 40 17 9 2 13 10 6 0 0.861 1.000 1.000 431 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 CASP8(1), CD14(1), CXCL9(2), FADD(2), IFNA8(1), IFNAR2(1), IRAK1(2), IRF3(1), IRF5(1), LBP(1), MAP2K3(2), MAP3K8(1), MAPK1(1), MAPK11(1), NFKB1(1), NFKB2(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), TBK1(1), TICAM1(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2) 12413567 38 25 37 40 4 3 14 11 6 0 1.000 1.000 1.000 432 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(2), ACTN4(1), DES(1), DMD(4), MYBPC1(1), MYBPC2(1), MYH3(2), MYH6(4), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(7), TNNT1(1), TNNT2(1), TPM2(2), TTN(28), VIM(1) 19293053 63 25 63 25 8 7 27 13 8 0 0.915 1.000 1.000 433 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 ATM(5), CCNB3(2), CCND2(1), CDC14A(1), CDC20(1), CDC7(1), CDH1(1), CDKN2A(2), CHEK2(2), DTX4(1), E2F3(1), EP300(2), ESPL1(1), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), MPL(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), TBC1D8(2), TFDP1(1) 15316585 42 24 42 27 7 2 15 3 15 0 1.000 1.000 1.000 434 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), DHODH(3), DPYD(2), DPYS(2), ENTPD4(3), ENTPD8(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), RFC5(1), RRM2(1), TXNRD2(1), UCK2(1) 11408708 36 24 34 14 6 4 14 6 6 0 0.865 1.000 1.000 435 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), B4GALT5(2), B4GALT7(1), C1GALT1(1), CHPF(2), CHST1(1), CHST11(1), CHST13(3), CHST3(1), EXT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), MAN2A1(2), MGAT3(1), NDST2(1), NDST4(2), OGT(1), RPN2(2), ST3GAL1(1), ST6GALNAC1(1), XYLT1(1) 15338154 52 24 51 25 7 4 19 14 8 0 0.968 1.000 1.000 436 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), ACVR1B(1), CDH1(1), CREBBP(1), CTNNA2(1), CTNNA3(1), EGFR(3), EP300(2), FARP2(1), IGF1R(1), INSR(1), MAPK1(1), PARD3(1), PTPN6(1), PTPRF(2), PTPRJ(3), PVRL1(2), PVRL3(2), PVRL4(1), SORBS1(1), TCF7L2(1), TGFBR2(2), TJP1(1), WAS(1), WASF2(1) 16480420 40 24 40 18 9 3 17 3 8 0 0.934 1.000 1.000 437 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 B2M(1), CANX(1), CD8A(1), CIITA(2), CTSL1(1), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(1), IFNA8(1), KIR2DL1(1), KIR3DL2(1), NFYA(1), TAP1(1), TAP2(1) 6199891 28 24 28 20 1 2 14 10 1 0 0.999 1.000 1.000 438 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 BRAF(1), CD247(1), FCGR3A(3), GZMB(1), HLA-C(2), HLA-G(1), ICAM1(1), IFNA8(1), IFNAR2(1), ITGAL(1), KIR2DL1(1), KIR3DL2(1), LAT(1), LCK(1), MAPK1(1), MICA(2), MICB(1), NFATC1(1), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTPN11(1), PTPN6(1), SHC2(2), SHC3(1), SOS2(1), SYK(1), TNFRSF10A(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1) 15523109 51 24 51 21 10 2 21 9 9 0 0.900 1.000 1.000 439 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 CARD11(3), CBL(1), CBLC(1), CD247(1), CD3D(1), CD8A(1), CTLA4(2), IL2(1), ITK(1), LAT(1), LCK(1), MAP3K8(1), NCK2(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), NRAS(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCQ(2), PTPN6(1), RASGRP1(2), SOS2(1), TEC(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1) 14113652 54 24 54 44 8 3 24 8 11 0 1.000 1.000 1.000 440 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(2), ACACB(4), BRAF(1), CALML3(1), CALML6(1), CBL(1), CBLC(1), FASN(3), G6PC2(1), INPP5D(1), INSR(1), IRS4(1), LIPE(2), MAPK1(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(2), PDE3B(1), PFKL(2), PHKA2(2), PHKB(3), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPARGC1A(2), PPP1CA(2), PPP1R3A(1), PRKAA2(1), PRKACA(1), PRKACB(1), PRKAG2(3), PRKAG3(1), PRKCI(1), PTPRF(2), PYGL(1), RAPGEF1(1), SHC2(2), SHC3(1), SORBS1(1), SOS2(1), TSC2(1) 22561056 64 24 64 40 14 3 18 16 13 0 1.000 1.000 1.000 441 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), BCAR1(1), BRAF(1), CDKN2A(2), DOCK1(2), ITGA10(2), ITGA2(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), MAPK1(1), MAPK8IP3(2), MYLK(2), MYLK2(2), P4HB(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PLCG1(3), ROCK1(2), SOS2(1), TLN1(2), TLN2(6), VASP(1), WAS(1), ZYX(1) 17141779 50 24 50 19 7 1 26 8 7 1 0.829 1.000 1.000 442 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 CABIN1(1), CAMK4(1), CEBPB(1), CREBBP(1), CTLA4(2), EGR2(1), EGR3(1), EP300(2), FCER1A(2), FCGR3A(3), GATA3(2), GATA4(2), IL2(1), IL3(1), ITK(1), KPNA5(2), NCK2(1), NFATC1(1), NFKB2(1), NFKBIE(2), NUP214(2), PIN1(1), PPP3CB(1), RPL13A(1), SLA(2), VAV1(3), VAV2(1), VAV3(3) 12632115 43 23 43 35 4 0 27 6 6 0 1.000 1.000 1.000 443 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 AMDHD1(18), AOC3(1), LCMT1(1), MAOA(3), UROC1(1), WBSCR22(1) 5576448 25 23 8 22 1 1 3 18 2 0 1.000 1.000 1.000 444 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(1), AREG(1), BRAF(1), CBL(1), CBLC(1), EGFR(3), ERBB3(1), ERBB4(5), GAB1(1), MAPK1(1), NCK2(1), NRAS(1), NRG2(2), NRG3(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), SHC2(2), SHC3(1), SOS2(1), STAT5B(1) 14418237 44 23 43 20 10 3 15 8 8 0 0.956 1.000 1.000 445 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(4), ACSL1(3), ACSL3(2), ADIPOR1(1), CAMKK2(1), CPT1C(1), G6PC2(1), IRS4(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), NFKB1(1), NFKB2(1), NFKBIE(2), PCK1(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(1), STK11(2), TNFRSF1A(1), TYK2(2) 11651382 43 23 43 44 5 3 18 8 9 0 1.000 1.000 1.000 446 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), ATP7B(3), COX4I1(1), COX6B1(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRFS1(12) 5287352 32 23 21 15 3 0 11 15 3 0 0.963 1.000 1.000 447 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ARHGAP4(1), ARHGEF11(2), BTK(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3R1(1), PITX2(3), ROCK1(2) 9764406 32 23 32 21 5 0 15 8 4 0 0.996 1.000 1.000 448 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BFAR(1), BTK(1), CAD(1), CASP8(1), DAXX(4), DFFA(1), EGFR(3), FADD(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PTPN13(2), ROCK1(2), TNFRSF6B(1) 10222698 30 23 30 35 6 2 12 4 6 0 1.000 1.000 1.000 449 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BCL2L1(2), BCL2L11(1), BIRC5(1), CASP8(1), DFFA(1), FADD(2), GZMB(1), HELLS(1), IRF2(3), IRF3(1), IRF4(1), IRF5(1), IRF6(1), MAP3K1(2), MDM2(2), NFKB1(1), NFKBIE(2), PLEKHG5(1), TNFRSF1A(1), TNFRSF21(1), TP73(1) 7907564 29 22 29 11 7 1 11 2 8 0 0.755 1.000 1.000 450 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(5), CCND2(1), CDKN2A(2), CREB3L1(1), CREB3L3(2), E2F3(1), MCM3(1), MDM2(2), NACA(4), POLA2(1), POLE(3), RB1(2), RBL1(1), RPA2(1), TFDP1(1), TNXB(3) 10474812 31 22 30 21 6 2 9 4 10 0 0.999 1.000 1.000 451 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(1), BAG4(1), CASP8(1), DAXX(4), DFFA(1), FADD(2), GSN(1), LMNB1(1), LMNB2(2), MAP3K1(2), MDM2(2), NFKB1(1), NUMA1(1), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1) 9734495 31 22 31 14 8 4 6 0 13 0 0.933 1.000 1.000 452 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(2), CD1A(1), CD1C(2), CD1E(1), CD3D(1), CD8A(1), CD9(1), CR1(1), CR2(2), CSF1(1), CSF1R(1), CSF2RA(1), CSF3R(1), EPO(1), FLT3(1), GP9(2), HLA-DRB1(3), IL3(1), IL4R(1), IL6R(1), IL9R(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGAM(2), MME(4) 11225194 43 22 42 21 4 4 23 5 6 1 0.977 1.000 1.000 453 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), COL2A1(1), CPSF1(2), CPSF3(1), CSTF2(1), DHX15(1), DHX38(1), DICER1(1), GIPC1(1), NCBP1(1), NXF1(1), PAPOLA(2), PRPF4B(1), PRPF8(2), PTBP2(1), RBM5(1), SF3B1(2), SNRPB2(1), SNRPE(1), SNRPN(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(3), SUPT5H(1), U2AF1(1) 14722487 32 22 32 12 7 1 12 4 7 1 0.925 1.000 1.000 454 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 ATP8A1(1), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CX3CR1(2), CXCR3(2), CXCR4(1), EDNRB(1), FPR1(2), FSHR(1), GALR3(1), MC1R(1), MC3R(1), NPY1R(1), OPRL1(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR3(1) 7004073 36 22 35 27 8 1 19 6 2 0 0.998 1.000 1.000 455 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 CKM(2), CKMT2(1), CPS1(3), DAO(2), EPRS(4), GLUD1(1), GLUD2(1), GOT1(1), GOT2(2), LAP3(1), NOS1(2), NOS3(4), PRODH(4), PYCRL(1), RARS2(2) 5034378 31 21 30 20 6 2 12 7 4 0 0.994 1.000 1.000 456 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 38 ALPI(1), ALPP(1), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC3(1), MOV10L1(1), PTS(1), RAD54B(1), RUVBL2(1), SETX(2), SMARCA2(4), SMARCA5(1), SPR(1) 8210361 27 21 26 12 2 2 9 5 9 0 0.971 1.000 1.000 457 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), DAXX(4), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MEF2C(2), MKNK1(1), NFKB1(1), RPS6KA1(1), RPS6KA4(2) 13721453 27 21 26 25 6 1 9 7 4 0 1.000 1.000 1.000 458 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CREBBP(1), DUSP1(1), EHHADH(1), EP300(2), HSD17B4(3), MAPK1(1), NCOA1(2), NCOR1(1), NCOR2(4), NR2F1(3), NRIP1(3), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACB(1), PTGS2(2), RB1(2), STAT5B(1) 8600457 31 21 31 12 3 1 12 9 6 0 0.870 1.000 1.000 459 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), DHODH(3), DPYD(2), DPYS(2), NT5E(1), NT5M(1), NUDT2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), RRM2(1), UCK2(1) 8059053 29 21 25 11 5 7 9 4 4 0 0.850 1.000 1.000 460 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(2), BTK(1), CD19(2), CDKN2A(2), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(4), ITPR3(5), PIK3CA(1), PITX2(3), PREX1(4), RPS6KA1(1), SYK(1), TEC(1), VAV1(3) 7727437 34 21 34 21 6 2 16 6 4 0 0.997 1.000 1.000 461 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH6(1), ADH7(2), AGK(1), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), GK2(1), GPAM(3), LCT(1), PNLIP(3), PNLIPRP1(2), PNPLA3(2), PPAP2C(1) 8295723 30 20 28 13 5 0 12 8 5 0 0.891 1.000 1.000 462 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH6(1), ADH7(2), AKR1C3(1), AKR1C4(1), CYP2B6(3), CYP2C9(1), DHDH(1), EPHX1(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 7961062 31 20 30 17 5 0 15 5 6 0 0.986 1.000 1.000 463 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(2), ESR1(1), HNF4A(1), NR1D1(1), NR1H2(2), NR2C2(1), NR2F1(3), NR4A1(1), NR4A2(2), NR5A1(2), NR5A2(1), PGR(1), PPARA(1), RARA(1), ROR1(1), RORA(1), RORC(2), THRA(1), VDR(1) 5931895 28 20 28 19 3 3 8 6 7 1 0.999 1.000 1.000 464 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), AOC3(1), CKM(2), CKMT2(1), CPS1(3), DAO(2), GLUD1(1), GOT1(1), GOT2(2), MAOA(3), NOS1(2), NOS3(4), P4HB(1) 6175914 24 19 24 27 5 1 10 3 5 0 1.000 1.000 1.000 465 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 36 AARS2(1), CARS2(1), EARS2(2), EPRS(4), FARS2(1), FARSB(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(1), RARS2(2), VARS(8), VARS2(1), WARS2(1) 7154241 29 19 24 12 5 1 12 7 4 0 0.899 1.000 1.000 466 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 BDKRB2(1), FLT4(6), KDR(1), NOS3(4), PDE2A(1), PDE3A(2), PDE3B(1), PRKACB(1), PRKG2(2), RYR2(12) 5749060 31 19 31 11 8 4 10 6 3 0 0.621 1.000 1.000 467 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ALG6(1), CCR3(1), CELSR1(3), CELSR2(1), CXCR3(2), EMR2(4), EMR3(1), FSHR(1), GPR133(1), GPR61(2), GPR84(2), GRM1(3), LGR6(2), LPHN2(1), LPHN3(3), SMO(3), SSTR2(1), TAAR5(4) 9265747 36 18 35 17 6 2 17 9 2 0 0.871 1.000 1.000 468 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B7(2), LCMT1(1), STS(2), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1), WBSCR22(1) 6816161 26 18 25 26 3 1 19 2 1 0 1.000 1.000 1.000 469 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), ESCO2(1), GOT1(1), GOT2(2), HGD(1), LCMT1(1), MAOA(3), MIF(3), PNPLA3(2), TH(3), TYRP1(1), WBSCR22(1) 7969514 26 18 25 13 6 1 11 4 4 0 0.934 1.000 1.000 470 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(2), BTK(1), CD19(2), CR2(2), CSK(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), SOS2(1), SYK(1), VAV1(3) 10205656 30 18 30 15 4 0 12 8 6 0 0.966 1.000 1.000 471 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), FLNA(3), FLNC(1), MYH2(2), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), ROCK1(2), VASP(1) 6673173 21 18 21 12 3 3 8 4 3 0 0.932 1.000 1.000 472 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(2), INPP5B(1), IPMK(1), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), SYNJ1(1) 10455225 25 17 25 27 6 1 10 6 2 0 1.000 1.000 1.000 473 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(1), EGFR(3), ERBB4(5), ETS2(1), FMN2(3), MAPK1(1), NOTCH1(4), NOTCH3(3), NOTCH4(2), PIWIL1(1), PIWIL3(2), SOS2(1) 6459451 27 17 26 18 6 1 10 5 5 0 0.997 1.000 1.000 474 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ARF3(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), GNAS(5), PDIA4(1), PLCG1(3) 5171329 22 17 22 10 4 3 8 3 4 0 0.883 1.000 1.000 475 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), CSK(1), CXCL1(1), EGFR(3), F11R(2), GIT1(1), MAPK11(1), NFKB1(1), NFKB2(1), NOD1(1), PLCG1(3), PTPN11(1), PTPRZ1(3), TCIRG1(1), TJP1(1) 9829690 30 17 30 29 5 0 13 4 8 0 1.000 1.000 1.000 476 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD3D(1), CSK(1), CTLA4(2), ITK(1), LAT(1), LCK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PLCG1(3), RASGRP1(2), SOS2(1), VAV1(3), ZAP70(1) 7943137 29 17 29 33 5 1 13 3 7 0 1.000 1.000 1.000 477 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), GAA(1), GUSB(1), HK2(3), HK3(3), MGAM(4), PYGL(1), SI(5), UGT1A3(1), UGT1A5(2), UGT2B15(2) 7959088 25 17 25 12 2 0 13 6 4 0 0.933 1.000 1.000 478 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(1), EP300(2), ERCC3(1), ESR1(1), GRIP1(3), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(4), NRIP1(3), PELP1(1) 6593744 23 16 23 23 0 0 12 6 5 0 1.000 1.000 1.000 479 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDIPT(1), CHAT(1), CHKB(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), GNPAT(1), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPAP2C(1) 7155619 29 16 27 11 5 1 13 6 4 0 0.782 1.000 1.000 480 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ENO2(1), ENO3(1), GOT1(1), GOT2(2), HK2(3), HK3(3), LDHA(3), MDH2(1), PC(1), PCK1(1), PDHB(1), PFKL(2), PGAM1(1), PGK2(3) 5825718 24 16 24 10 5 1 10 6 2 0 0.776 1.000 1.000 481 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 FUK(3), GMPPB(1), HK2(3), HK3(3), KHK(2), LHPP(2), MTMR1(1), MTMR2(1), PFKL(2) 5284899 18 16 17 12 5 3 6 2 2 0 0.965 1.000 1.000 482 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(1), MAPK1(1), MAPK11(1), NFATC1(1), NOS3(4), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTGS2(2), SH2D2A(1), SHC2(2), SPHK1(2), SPHK2(2) 10141267 37 16 37 13 7 2 14 8 6 0 0.784 1.000 1.000 483 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ACTG1(2), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1), WAS(1), YWHAQ(1) 6920522 20 16 20 10 4 4 9 1 2 0 0.900 1.000 1.000 484 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ACTG1(2), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1), WAS(1), YWHAQ(1) 6920522 20 16 20 10 4 4 9 1 2 0 0.900 1.000 1.000 485 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PIK3CB(1), PITX2(3), PLCB1(3), PLCB3(1), PLCB4(1), SOS2(1) 8109429 26 16 26 15 6 1 10 8 1 0 0.965 1.000 1.000 486 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ITPR1(2), ITPR2(4), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PITX2(3), PLD2(1) 6392959 22 16 22 30 3 1 13 5 0 0 1.000 1.000 1.000 487 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF1(1), EIF2B5(1), FLT4(6), KDR(1), NOS3(4), PIK3CA(1), PIK3R1(1), PLCG1(3) 4790033 18 16 18 7 6 3 5 4 0 0 0.691 1.000 1.000 488 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(4), CCND2(1), DVL1(1), DVL2(1), FZD5(1), FZD7(1), FZD8(2), LDLR(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 7683165 27 16 27 14 5 1 11 4 5 1 0.963 1.000 1.000 489 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(5), ATR(3), CHEK2(2), EP300(2), MDM2(2), PRKDC(3), RPS6KA1(1), YWHAQ(1) 5789059 19 15 19 16 1 1 6 2 9 0 1.000 1.000 1.000 490 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH6(1), ADH7(2), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), LCT(1), PNLIP(3), PNLIPRP1(2), PPAP2C(1) 6842404 22 15 20 10 3 0 9 7 3 0 0.925 1.000 1.000 491 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(1), ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), G6PC2(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PFKL(2), PGAM1(1), PGK2(3) 8038336 24 15 24 15 4 1 8 8 3 0 0.987 1.000 1.000 492 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), HADH(1), HADHA(1), HSD17B4(3), NSD1(4), OGDHL(1), PIPOX(1), PLOD3(2), SETD1A(1), SETDB1(1), SHMT2(1) 8016166 28 15 28 11 4 2 13 3 6 0 0.803 1.000 1.000 493 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(1), ALOX12B(1), ALOX5(3), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP2U1(2), CYP4F2(1), CYP4F3(1), GPX1(1), GPX7(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PTGDS(1), PTGS1(1), PTGS2(2) 5414933 28 15 28 11 3 2 13 4 6 0 0.838 1.000 1.000 494 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACSL1(3), ACSL3(2), ANGPTL4(1), CPT1C(1), EHHADH(1), FABP2(1), FADS2(1), GK2(1), HMGCS2(1), PCK1(1), PPARA(1), SLC27A1(3), SLC27A5(1), SORBS1(1) 8758457 19 15 19 11 4 2 9 2 2 0 0.960 1.000 1.000 495 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 BTK(1), FCER1A(2), IL3(1), INPP5D(1), LAT(1), MAP2K3(2), MAPK1(1), MAPK11(1), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), SOS2(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 9889341 37 15 37 15 5 1 13 9 9 0 0.929 1.000 1.000 496 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), B3GALT4(1), CDR1(1), DGKI(1), RPL12(1), RPL13A(1), RPL14(1), RPL22(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS6KA1(1), RPS6KA6(1), RPS9(1), SLC36A2(1), UBB(1) 7157472 24 15 24 30 3 0 14 4 3 0 1.000 1.000 1.000 497 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 BCL2L1(2), CDKN2A(2), ERBB4(5), GAB1(1), IGFBP1(1), IRS4(1), PAK3(3), PAK4(1), PAK7(2), PARD3(1), PIK3CA(1), PREX1(4), RPS6KA1(1), SOS2(1), TSC2(1), YWHAQ(1) 10609618 28 15 28 31 4 3 12 3 6 0 1.000 1.000 1.000 498 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(4), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PITX2(3), PTX3(1), RYR1(4) 6493567 24 15 24 14 4 0 11 7 2 0 0.965 1.000 1.000 499 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 35 AGXT(2), AOC3(1), ATP6V0C(1), CHKB(1), CTH(1), DAO(2), GCAT(2), MAOA(3), PEMT(1), PLCG1(3), SARDH(1), SHMT2(1) 5635340 19 14 18 10 6 1 5 3 4 0 0.932 1.000 1.000 500 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 53 BMP6(1), BMP8B(1), CSNK1G1(1), DHH(2), GLI2(2), HHIP(2), LRP2(2), PRKACA(1), PRKACB(1), PTCH1(2), SHH(2), SMO(3), SUFU(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 7864594 30 14 30 15 7 2 10 3 7 1 0.967 1.000 1.000 501 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), CASP8(1), INSR(1), ITCH(1), MAGI1(2), MAGI2(4), RERE(2), WWP1(1), WWP2(1) 3267801 18 14 15 10 2 0 13 2 1 0 0.967 1.000 1.000 502 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(1), CREBBP(1), EGR1(2), EGR2(1), EGR3(1), EGR4(3), MAP1B(2), MAPK1(1), MAPK8IP3(2), NTRK1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PTPN11(1), TH(3) 7298494 22 14 22 11 5 0 9 6 2 0 0.920 1.000 1.000 503 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(3), GNAS(5), GNB1(2), IGF1R(1), MAPK1(1), MKNK1(1), NGFR(2), PDGFRA(1), RPS6KA1(1) 4682544 17 13 17 14 7 0 5 3 2 0 0.998 1.000 1.000 504 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1) 6723625 17 13 17 12 3 1 6 5 2 0 0.986 1.000 1.000 505 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1) 6723625 17 13 17 12 3 1 6 5 2 0 0.986 1.000 1.000 506 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 BTK(1), CARD11(3), CD19(2), CR2(2), INPP5D(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PTPN6(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 10381980 32 13 32 37 3 1 15 6 7 0 1.000 1.000 1.000 507 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), OCRL(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3) 6301369 14 13 14 19 3 1 5 5 0 0 1.000 1.000 1.000 508 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(3), ARPC2(1), GSN(1), MYLK(2), ROCK1(2), TLN1(2) 6482355 17 13 17 12 3 1 7 4 2 0 0.990 1.000 1.000 509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 BRD4(1), CBL(1), CDKN2A(2), IGFBP1(1), IRS4(1), LNPEP(1), MAPK1(1), PARD3(1), PIK3CA(1), PIK3R1(1), PPYR1(3), RPS6KA1(1), SORBS1(1), SOS2(1), YWHAQ(1) 8102309 18 13 18 25 3 2 8 2 3 0 1.000 1.000 1.000 510 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CXCR4(1), GNB1(2), MAPK1(1), NFKB1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PLCG1(3) 3930721 12 12 12 11 2 0 7 2 1 0 0.997 1.000 1.000 511 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(2), GNB1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), NFATC1(1), NFKB1(1), PIK3C2G(1), PLCB1(3), PPP3CB(1) 5402763 16 12 16 7 2 0 11 3 0 0 0.824 1.000 1.000 512 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(2), DEGS2(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SGPP1(1), SMPD4(1), SPHK1(2), SPHK2(2), SPTLC1(1), SPTLC2(1) 4959348 17 12 17 10 3 0 11 1 2 0 0.944 1.000 1.000 513 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 ARHGEF11(2), LPA(1), MAP3K1(2), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PLD2(1), ROCK1(2), SERPINA4(1), SRF(1), TBXA2R(1) 6776364 18 12 18 32 4 1 11 2 0 0 1.000 1.000 1.000 514 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AOC3(1), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), ECHS1(2), EHHADH(1), HADHA(1), KMO(1), MAOA(3), SDS(1), TDO2(1), WARS2(1) 7589596 19 12 19 11 3 0 10 2 4 0 0.976 1.000 1.000 515 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), STS(2), UGT1A3(1), UGT1A5(2), UGT2B15(2) 3737212 14 11 14 21 2 0 9 2 1 0 1.000 1.000 1.000 516 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(2), MEF2C(2), NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), RPS6KA1(1) 2746477 12 11 11 11 2 0 7 3 0 0 0.998 1.000 1.000 517 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(1), MAPK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PRKAA2(1), RPS6KA1(1), RPS6KA6(1), STK11(2), TSC2(1), ULK1(1), ULK2(1), ULK3(1), VEGFB(1) 7461347 19 11 19 16 0 2 7 5 5 0 1.000 1.000 1.000 518 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(4), MAP3K1(2), MEF2C(2), MKNK1(1), PLA2G4A(3) 5167366 12 11 12 11 2 1 4 2 3 0 0.999 1.000 1.000 519 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), PAPPA(6), RPS6KA1(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 4474000 22 11 22 13 3 1 12 2 4 0 0.987 1.000 1.000 520 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(2), BTK(1), CD19(2), CSK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1), SERPINA4(1), SOS2(1), SYK(1), VAV1(3) 7364458 19 11 19 34 2 0 10 3 4 0 1.000 1.000 1.000 521 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), CASP8(1), FADD(2), MAP3K3(1), NFKB1(1), NFKB2(1), NFKBIE(2), NR2C2(1), TNFRSF1A(1) 3855721 11 11 11 28 2 1 6 0 2 0 1.000 1.000 1.000 522 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), GNB1(2), MAPK1(1), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCB1(3), SPHK1(2) 3738001 12 10 12 10 2 0 4 5 1 0 0.996 1.000 1.000 523 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGFR(3), JAK1(1), MAP3K1(2), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1) 5144481 12 10 12 7 6 0 5 1 0 0 0.916 1.000 1.000 524 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 30 ACP5(1), ACPP(1), ALPI(1), ALPP(1), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), PON1(1) 3947094 12 10 12 9 1 1 8 2 0 0 0.976 1.000 1.000 525 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 CABIN1(1), IGF1R(1), INSR(1), MAPK7(2), MEF2C(2), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1) 4835171 11 10 10 7 2 0 6 3 0 0 0.934 1.000 1.000 526 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA2A(2), ADRA2C(4), CHRM5(1), DRD3(1), DRD5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2) 3557253 16 10 15 10 4 2 5 3 2 0 0.916 1.000 1.000 527 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA5(1), EDNRB(1), HSD11B1(1), PLA2G4A(3), PTGDS(1), PTGER4(1), PTGIR(1), PTGS1(1), PTGS2(2) 2881890 13 10 13 29 2 0 6 3 2 0 1.000 1.000 1.000 528 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 GNB1(2), JAK2(2), MAPK1(1), MYLK(2), PLCG1(3) 5840599 10 9 10 8 2 0 5 3 0 0 0.985 1.000 1.000 529 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 DHCR24(2), DHCR7(1), FDFT1(1), HMGCR(1), HSD17B7(2), NSDHL(1), SQLE(2) 2660401 10 9 10 21 1 0 6 1 2 0 1.000 1.000 1.000 530 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(1), ALDH18A1(2), AOC3(1), CPS1(3), MAOA(3), SAT1(2), SRM(1) 4123592 13 9 13 21 1 0 7 0 5 0 1.000 1.000 1.000 531 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1RN(2), IRAK1(2), IRAK2(2), MAP2K3(2), MAP3K1(2), NFKB1(1) 4092020 11 9 10 8 3 0 5 3 0 0 0.981 1.000 1.000 532 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGEF1(1), GNB1(2), MYLK(2), PLCB1(3), ROCK1(2) 2821921 10 9 10 5 1 0 8 1 0 0 0.882 1.000 1.000 533 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), GNB1(2), PIK3CA(1), PIK3R1(1), PLCB1(3), ROCK1(2) 3528287 11 9 11 8 1 0 7 3 0 0 0.981 1.000 1.000 534 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(1), ETS2(1), HDAC2(1), NCOR2(4), RBL1(1), SIN3B(2) 3753036 11 8 11 10 3 0 3 3 2 0 0.996 1.000 1.000 535 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 INSR(1), JAK2(2), MAPK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PTPN6(1), RPS6KA1(1), SRF(1), STAT5B(1) 4567681 13 8 13 15 4 0 3 4 2 0 1.000 1.000 1.000 536 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SLC27A5(1), SOAT2(1) 4425646 10 8 10 29 3 0 4 2 1 0 1.000 1.000 1.000 537 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SRM(1) 3700339 10 8 10 13 2 0 5 0 3 0 1.000 1.000 1.000 538 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(3), CYP2C9(1), CYP2J2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1) 3355977 12 8 12 10 1 1 6 2 2 0 0.993 1.000 1.000 539 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ADCY1(1), GNAS(5), GNB1(2), MAPK1(1), PIN1(1), PRKACB(1), RPS6KA1(1) 2793566 12 8 12 11 2 0 4 3 3 0 1.000 1.000 1.000 540 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 JAK1(1), MAP3K1(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1) 4808114 10 8 10 8 4 0 4 2 0 0 0.979 1.000 1.000 541 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), MAP2K3(2), MAP3K1(2), MAPK1(1), PLCG1(3) 3956837 9 8 9 5 3 0 4 2 0 0 0.870 1.000 1.000 542 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IL4R(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), SOS2(1), STAT6(1) 5033104 10 8 10 12 1 1 3 4 1 0 1.000 1.000 1.000 543 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 DUSP1(1), MAP2K3(2), MAP3K4(1), MAPK1(1), MAPK11(1), MKNK1(1), MYEF2(1), NFKB1(1), NR2C2(1), SRF(1) 4725995 11 8 11 11 3 0 5 3 0 0 0.998 1.000 1.000 544 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), BTK(1), CDKN2A(2), DAPP1(1), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(1), RPS6KA1(1), SOS2(1), TEC(1), YWHAQ(1) 4913381 13 8 13 14 1 1 5 3 3 0 1.000 1.000 1.000 545 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), JAK2(2), NFKB1(1), RB1(2), TNFRSF1A(1), USH1C(2), WT1(2) 2423990 11 8 11 13 2 1 4 2 2 0 0.999 1.000 1.000 546 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(2), CLTB(3), COPA(1), GPLD1(1) 2237046 8 7 8 5 2 1 4 1 0 0 0.911 1.000 1.000 547 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 EGFR(3), MAP3K1(2), MAPK1(1), MEF2C(2) 4706781 8 7 8 7 3 0 3 2 0 0 0.971 1.000 1.000 548 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SOAT2(1) 3197010 9 7 9 24 3 0 3 2 1 0 1.000 1.000 1.000 549 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(1), GNAS(5), MAPK1(1), PIK3CA(1), PIK3R1(1), PRKACB(1), RPS6KA1(1) 3957942 11 7 11 13 1 0 3 4 3 0 1.000 1.000 1.000 550 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(2), GABRA2(2), GABRA6(2), UBQLN1(1) 1666679 7 7 7 5 0 0 6 1 0 0 0.955 1.000 1.000 551 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), OGDHL(1), PC(1), PCK1(1), SDHA(1), SDHB(1), SDHD(1) 4121947 12 7 12 8 1 1 7 3 0 0 0.954 1.000 1.000 552 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 G6PD(2), PFKL(2), PRPS1L1(1), RPIA(1), TKTL2(3) 3388656 9 7 8 22 3 2 2 2 0 0 1.000 1.000 1.000 553 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT2(1), B4GALT7(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), DSE(2), XYLT1(1) 1975850 12 7 11 7 1 3 4 4 0 0 0.907 1.000 1.000 554 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PDHB(1), PDK3(1), SDHA(1), SDHB(1), SDHD(1) 3941144 11 7 11 6 0 1 7 3 0 0 0.902 1.000 1.000 555 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 NGFR(2), PIK3CA(1), PIK3R1(1), PLCG1(3) 2622224 7 7 7 5 4 0 2 1 0 0 0.944 1.000 1.000 556 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), NCOA1(2), NCOA2(1), NCOR2(4), RARA(1) 3497593 9 7 9 19 0 0 4 3 2 0 1.000 1.000 1.000 557 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1A(2), PLCB1(3), TRH(1), VIP(1) 1529228 8 7 8 8 1 1 3 3 0 0 0.994 1.000 1.000 558 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), MAPK1(1), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1) 4905966 11 7 11 27 0 0 8 3 0 0 1.000 1.000 1.000 559 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(1), DUSP6(1), MAP3K8(1), MAPK1(1), MKNK1(1), NFKB1(1), RPS6KA1(1), SOS2(1) 4154375 8 7 8 13 2 0 2 3 1 0 1.000 1.000 1.000 560 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRB1(3), IL18R1(2), IL2(1), IL4R(1) 1757866 7 7 7 5 0 1 5 1 0 0 0.950 1.000 1.000 561 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(2), CKM(2), CKMT2(1), CPS1(3), GLUD1(1) 2478521 9 7 9 18 1 0 4 2 2 0 1.000 1.000 1.000 562 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(3), PIK3CA(1), PIK3R1(1), TERT(1) 2334257 6 6 6 5 1 1 2 2 0 0 0.972 1.000 1.000 563 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), EDNRB(1), EGFR(3), NFKB1(1), PLCG1(3) 2820401 10 6 10 5 5 1 4 0 0 0 0.786 1.000 1.000 564 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(1), EGFR(3), PDGFRA(1) 2688027 6 6 6 6 3 1 1 1 0 0 0.974 1.000 1.000 565 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTAP(1), MTR(1), SRM(1) 2810136 7 6 7 16 2 1 1 2 1 0 1.000 1.000 1.000 566 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL12(1), RPL13A(1), RPL14(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS9(1) 3005463 9 6 9 18 1 0 5 2 1 0 1.000 1.000 1.000 567 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(2), JAK3(3), PTPRU(1) 1949573 7 6 7 4 1 0 3 3 0 0 0.895 1.000 1.000 568 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 MAP2K3(2), MAP3K1(2), NFKB1(1), TANK(1), TNFRSF1A(1) 3392925 7 6 7 5 1 0 5 1 0 0 0.957 1.000 1.000 569 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3) 2149728 6 6 6 5 2 0 3 1 0 0 0.973 1.000 1.000 570 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 NFATC1(1), PLCG1(3), PPP3CB(1) 2810464 5 5 5 3 2 0 3 0 0 0 0.850 1.000 1.000 571 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH6(1), ADH7(2), DHRS3(1), ESCO2(1), PNPLA3(2) 3373856 7 5 7 10 1 0 1 3 2 0 1.000 1.000 1.000 572 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IGF1R(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1) 3393530 5 5 5 6 2 0 1 2 0 0 0.994 1.000 1.000 573 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 INSR(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1) 3500430 5 5 5 6 2 0 1 2 0 0 0.995 1.000 1.000 574 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), IMPDH1(1), OAZ1(1), POLD1(2), POLG(1), SRM(1) 1820802 8 5 8 10 1 0 6 0 1 0 1.000 1.000 1.000 575 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 35 ERCC3(1), POLR1A(1), POLR2B(2), POLR2H(1) 4617384 5 5 5 12 0 0 3 0 2 0 1.000 1.000 1.000 576 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(2), MTNR1B(2), PTGER4(1), PTGIR(1), TBXA2R(1) 1592463 7 5 6 24 1 0 4 2 0 0 1.000 1.000 1.000 577 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGFR(3), MAPK1(1) 3440258 5 5 5 3 2 1 1 1 0 0 0.897 1.000 1.000 578 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(1), L1CAM(1), SELP(2) 2160102 4 4 4 3 0 0 3 1 0 0 0.950 1.000 1.000 579 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A6(1), XDH(3) 1104561 4 4 4 4 0 0 4 0 0 0 0.981 1.000 1.000 580 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), IGF1R(1), PIK3CA(1), PIK3R1(1) 2737483 4 4 4 3 1 0 2 1 0 0 0.941 1.000 1.000 581 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(1), MAPK1(1), PIK3CA(1), PIK3R1(1) 2578803 4 4 4 5 1 0 1 2 0 0 0.994 1.000 1.000 582 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3) 932023 5 4 5 6 4 0 1 0 0 0 0.979 1.000 1.000 583 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 G6PD(2), PRPS1L1(1), RPIA(1) 2792592 4 4 4 21 1 1 1 1 0 0 1.000 1.000 1.000 584 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK4(1), MEF2C(2), PPARA(1), PPP3CB(1) 2947084 5 4 5 4 0 0 3 2 0 0 0.951 1.000 1.000 585 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), MAPK1(1), PIK3CA(1), PIK3R1(1) 2652790 4 4 4 4 0 0 2 2 0 0 0.984 1.000 1.000 586 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 NGFR(2), NTRK1(1), PIK3CA(1) 2310427 4 4 4 3 2 0 1 1 0 0 0.922 1.000 1.000 587 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 NFKB1(1), PIK3CA(1), PIK3R1(1) 1960870 3 3 3 3 0 0 2 1 0 0 0.974 1.000 1.000 588 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 EPO(1), FLT3(1), IL3(1) 1181788 3 3 3 3 0 1 2 0 0 0 0.971 1.000 1.000 589 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 9 EPX(1), MTHFR(1), SHMT2(1) 1368739 3 3 3 4 3 0 0 0 0 0 0.985 1.000 1.000 590 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 IGF1R(1), PIK3CA(1), PIK3R1(1) 1819978 3 3 3 10 1 0 1 1 0 0 1.000 1.000 1.000 591 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), WT1(2) 859807 3 3 3 12 1 0 2 0 0 0 1.000 1.000 1.000 592 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL2(1), IL3(1) 1357080 2 2 2 3 0 0 2 0 0 0 0.986 1.000 1.000 593 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), FH(1), SDHA(1) 1302039 3 2 3 3 0 0 3 0 0 0 0.955 1.000 1.000 594 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 CS(1), PC(1) 1285111 2 2 2 2 0 0 1 1 0 0 0.946 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CSK(1), PTPRA(1) 1289703 2 2 2 2 0 0 2 0 0 0 0.942 1.000 1.000 596 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2S(1), UBE3A(1) 1438151 2 2 2 2 0 0 1 1 0 0 0.969 1.000 1.000 597 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1) 745186 1 1 1 3 0 0 1 0 0 0 0.995 1.000 1.000 598 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 6 EPX(1) 935346 1 1 1 2 1 0 0 0 0 0 0.987 1.000 1.000 599 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL2(1) 421269 1 1 1 3 0 0 1 0 0 0 0.998 1.000 1.000 600 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(2) 797566 2 1 2 3 2 0 0 0 0 0 0.951 1.000 1.000 601 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 705469 1 1 1 4 1 0 0 0 0 0 0.996 1.000 1.000 602 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(1) 1044551 1 1 1 3 0 0 1 0 0 0 0.997 1.000 1.000 603 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1) 795888 1 1 1 2 0 0 1 0 0 0 0.985 1.000 1.000 604 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 1102162 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 1102162 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 438328 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 1200125 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 1184524 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 242694 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 659724 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 68925 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 297389 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 664942 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 525727 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 550206 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 822643 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000