HotNet pathway analysis of mutation and copy number data
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
16 April 2014
|
analyses__2014_04_16
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C1CN72H7
Overview
Introduction
Summary
There were 2 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 2 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 2 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| CKM(7),MYOM2(18),CAPN3(8),TTN(22),TRIM54(9) | 5 | 0.001 | 1 |
| LILRB2(7),HLA-B(14),HLA-F(13),B2M(8),KIR3DL1(7),MAGEA1(8) | 6 | 0.024 | 1 |
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.