This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.
Testing the association between mutation status of 24 genes and 10 molecular subtypes across 223 patients, 10 significant findings detected with P value < 0.05 and Q value < 0.25.
-
FBXW7 mutation correlated to 'CN_CNMF'.
-
BRAF mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'CN_CNMF'.
-
KRAS mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'MRNASEQ_CNMF'.
-
TP53 mutation correlated to 'MRNA_CHIERARCHICAL' and 'CN_CNMF'.
-
PIK3CA mutation correlated to 'CN_CNMF'.
Table 1. Get Full Table Overview of the association between mutation status of 24 genes and 10 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, 10 significant findings detected.
Clinical Features |
MRNA CNMF |
MRNA CHIERARCHICAL |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
||
nMutated (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
BRAF | 22 (10%) | 201 |
2.84e-06 (0.000594) |
1.41e-07 (2.97e-05) |
0.000332 (0.0675) |
0.482 (1.00) |
0.304 (1.00) |
0.371 (1.00) |
0.527 (1.00) |
1 (1.00) |
0.684 (1.00) |
|
KRAS | 96 (43%) | 127 |
7.86e-05 (0.0162) |
4.23e-05 (0.00877) |
0.322 (1.00) |
0.107 (1.00) |
0.565 (1.00) |
1 (1.00) |
0.00015 (0.0307) |
0.829 (1.00) |
0.0218 (1.00) |
0.0431 (1.00) |
TP53 | 119 (53%) | 104 |
0.00206 (0.414) |
0.000493 (0.0995) |
1.15e-10 (2.42e-08) |
0.562 (1.00) |
0.755 (1.00) |
0.014 (1.00) |
1 (1.00) |
0.0307 (1.00) |
0.567 (1.00) |
|
FBXW7 | 38 (17%) | 185 |
0.0626 (1.00) |
0.0455 (1.00) |
2.6e-05 (0.00541) |
0.0122 (1.00) |
0.0362 (1.00) |
0.00272 (0.54) |
1 (1.00) |
0.416 (1.00) |
0.156 (1.00) |
|
PIK3CA | 33 (15%) | 190 |
0.208 (1.00) |
0.569 (1.00) |
0.00032 (0.0652) |
0.0673 (1.00) |
0.129 (1.00) |
0.0279 (1.00) |
0.685 (1.00) |
0.165 (1.00) |
1 (1.00) |
|
APC | 160 (72%) | 63 |
0.00773 (1.00) |
0.0271 (1.00) |
0.119 (1.00) |
0.466 (1.00) |
0.461 (1.00) |
0.619 (1.00) |
0.0699 (1.00) |
0.34 (1.00) |
0.837 (1.00) |
|
NRAS | 20 (9%) | 203 |
0.0478 (1.00) |
0.127 (1.00) |
0.199 (1.00) |
0.909 (1.00) |
0.474 (1.00) |
0.332 (1.00) |
1 (1.00) |
0.268 (1.00) |
1 (1.00) |
|
SMAD4 | 26 (12%) | 197 |
0.0322 (1.00) |
0.289 (1.00) |
0.0646 (1.00) |
0.827 (1.00) |
0.339 (1.00) |
0.417 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
FAM123B | 25 (11%) | 198 |
0.0787 (1.00) |
0.0924 (1.00) |
0.00912 (1.00) |
0.345 (1.00) |
0.588 (1.00) |
0.0941 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
SMAD2 | 15 (7%) | 208 |
0.134 (1.00) |
0.518 (1.00) |
0.161 (1.00) |
0.592 (1.00) |
0.133 (1.00) |
0.57 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
TCF7L2 | 18 (8%) | 205 |
1 (1.00) |
0.416 (1.00) |
0.00239 (0.479) |
0.836 (1.00) |
0.896 (1.00) |
0.334 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
ACVR2A | 9 (4%) | 214 |
0.00717 (1.00) |
0.184 (1.00) |
0.0236 (1.00) |
0.0952 (1.00) |
0.469 (1.00) |
0.868 (1.00) |
1 (1.00) |
0.173 (1.00) |
1 (1.00) |
|
SOX9 | 10 (4%) | 213 |
0.129 (1.00) |
0.123 (1.00) |
0.00856 (1.00) |
0.189 (1.00) |
0.694 (1.00) |
0.782 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
ELF3 | 6 (3%) | 217 |
0.363 (1.00) |
0.811 (1.00) |
0.273 (1.00) |
0.544 (1.00) |
0.436 (1.00) |
0.014 (1.00) |
0.178 (1.00) |
1 (1.00) |
1 (1.00) |
|
CRTC1 | 6 (3%) | 217 |
0.123 (1.00) |
0.165 (1.00) |
0.273 (1.00) |
0.175 (1.00) |
0.482 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
TNFRSF10C | 6 (3%) | 217 |
0.317 (1.00) |
0.287 (1.00) |
0.707 (1.00) |
0.278 (1.00) |
0.378 (1.00) |
0.248 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
KIAA1804 | 15 (7%) | 208 |
0.271 (1.00) |
0.394 (1.00) |
0.028 (1.00) |
0.506 (1.00) |
0.474 (1.00) |
0.57 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
KRTAP5-5 | 4 (2%) | 219 |
0.327 (1.00) |
0.482 (1.00) |
0.839 (1.00) |
0.385 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
PTEN | 7 (3%) | 216 |
0.0276 (1.00) |
0.337 (1.00) |
0.07 (1.00) |
0.544 (1.00) |
0.436 (1.00) |
0.098 (1.00) |
1 (1.00) |
0.347 (1.00) |
0.298 (1.00) |
|
ACOT4 | 3 (1%) | 220 |
0.255 (1.00) |
0.49 (1.00) |
0.792 (1.00) |
0.557 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|||
MYO1B | 13 (6%) | 210 |
0.00868 (1.00) |
0.00887 (1.00) |
0.00479 (0.949) |
0.0215 (1.00) |
0.469 (1.00) |
0.187 (1.00) |
0.351 (1.00) |
1 (1.00) |
1 (1.00) |
|
PCBP1 | 6 (3%) | 217 |
0.234 (1.00) |
0.811 (1.00) |
0.795 (1.00) |
0.648 (1.00) |
0.482 (1.00) |
0.8 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|
GGT1 | 3 (1%) | 220 |
0.162 (1.00) |
0.557 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
|||||
ACVR1B | 14 (6%) | 209 |
0.374 (1.00) |
0.316 (1.00) |
0.0986 (1.00) |
0.735 (1.00) |
0.376 (1.00) |
1 (1.00) |
1 (1.00) |
0.581 (1.00) |
1 (1.00) |
P value = 0.00773 (Fisher's exact test), Q value = 1
Table S1. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
APC MUTATED | 21 | 46 | 50 | 30 |
APC WILD-TYPE | 21 | 11 | 17 | 9 |
Figure S1. Get High-res Image Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D1V1.png)
P value = 0.0271 (Fisher's exact test), Q value = 1
Table S2. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
APC MUTATED | 32 | 35 | 35 | 45 |
APC WILD-TYPE | 8 | 13 | 26 | 11 |
Figure S2. Get High-res Image Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D1V2.png)
P value = 0.119 (Fisher's exact test), Q value = 1
Table S3. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
APC MUTATED | 54 | 53 | 47 | 3 |
APC WILD-TYPE | 15 | 32 | 15 | 1 |
P value = 0.466 (Fisher's exact test), Q value = 1
Table S4. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
APC MUTATED | 32 | 44 | 17 | 18 |
APC WILD-TYPE | 8 | 23 | 7 | 8 |
P value = 0.461 (Fisher's exact test), Q value = 1
Table S5. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
APC MUTATED | 16 | 75 | 15 | 5 |
APC WILD-TYPE | 4 | 34 | 4 | 4 |
P value = 0.619 (Fisher's exact test), Q value = 1
Table S6. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
APC MUTATED | 5 | 21 | 10 | 122 |
APC WILD-TYPE | 2 | 7 | 7 | 46 |
P value = 0.0699 (Fisher's exact test), Q value = 1
Table S7. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
APC MUTATED | 3 | 155 | 0 |
APC WILD-TYPE | 2 | 58 | 2 |
P value = 0.34 (Fisher's exact test), Q value = 1
Table S8. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
APC MUTATED | 3 | 5 | 141 |
APC WILD-TYPE | 0 | 4 | 53 |
P value = 0.837 (Fisher's exact test), Q value = 1
Table S9. Gene #1: 'APC MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
APC MUTATED | 6 | 1 | 142 |
APC WILD-TYPE | 2 | 1 | 54 |
P value = 0.0626 (Fisher's exact test), Q value = 1
Table S10. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
FBXW7 MUTATED | 11 | 6 | 7 | 9 |
FBXW7 WILD-TYPE | 31 | 51 | 60 | 30 |
P value = 0.0455 (Fisher's exact test), Q value = 1
Table S11. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
FBXW7 MUTATED | 4 | 5 | 17 | 7 |
FBXW7 WILD-TYPE | 36 | 43 | 44 | 49 |
Figure S3. Get High-res Image Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D2V2.png)
P value = 2.6e-05 (Fisher's exact test), Q value = 0.0054
Table S12. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
FBXW7 MUTATED | 2 | 26 | 9 | 1 |
FBXW7 WILD-TYPE | 67 | 59 | 53 | 3 |
Figure S4. Get High-res Image Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D2V3.png)
P value = 0.0122 (Fisher's exact test), Q value = 1
Table S13. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
FBXW7 MUTATED | 7 | 9 | 2 | 11 |
FBXW7 WILD-TYPE | 33 | 58 | 22 | 15 |
Figure S5. Get High-res Image Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
![](D2V5.png)
P value = 0.0362 (Fisher's exact test), Q value = 1
Table S14. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
FBXW7 MUTATED | 3 | 18 | 8 | 0 |
FBXW7 WILD-TYPE | 17 | 91 | 11 | 9 |
Figure S6. Get High-res Image Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
![](D2V6.png)
P value = 0.00272 (Fisher's exact test), Q value = 0.54
Table S15. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
FBXW7 MUTATED | 0 | 12 | 1 | 25 |
FBXW7 WILD-TYPE | 7 | 16 | 16 | 143 |
Figure S7. Get High-res Image Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
![](D2V7.png)
P value = 1 (Fisher's exact test), Q value = 1
Table S16. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
FBXW7 MUTATED | 1 | 37 | 0 |
FBXW7 WILD-TYPE | 4 | 176 | 2 |
P value = 0.416 (Fisher's exact test), Q value = 1
Table S17. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
FBXW7 MUTATED | 0 | 0 | 36 |
FBXW7 WILD-TYPE | 3 | 9 | 158 |
P value = 0.156 (Fisher's exact test), Q value = 1
Table S18. Gene #2: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
FBXW7 MUTATED | 0 | 1 | 35 |
FBXW7 WILD-TYPE | 8 | 1 | 161 |
P value = 0.0478 (Fisher's exact test), Q value = 1
Table S19. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
NRAS MUTATED | 0 | 8 | 6 | 5 |
NRAS WILD-TYPE | 42 | 49 | 61 | 34 |
Figure S8. Get High-res Image Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D3V1.png)
P value = 0.127 (Fisher's exact test), Q value = 1
Table S20. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
NRAS MUTATED | 1 | 8 | 4 | 6 |
NRAS WILD-TYPE | 39 | 40 | 57 | 50 |
P value = 0.199 (Fisher's exact test), Q value = 1
Table S21. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
NRAS MUTATED | 9 | 9 | 2 | 0 |
NRAS WILD-TYPE | 60 | 76 | 60 | 4 |
P value = 0.909 (Fisher's exact test), Q value = 1
Table S22. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
NRAS MUTATED | 3 | 7 | 1 | 2 |
NRAS WILD-TYPE | 37 | 60 | 23 | 24 |
P value = 0.474 (Fisher's exact test), Q value = 1
Table S23. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
NRAS MUTATED | 0 | 10 | 2 | 1 |
NRAS WILD-TYPE | 20 | 99 | 17 | 8 |
P value = 0.332 (Fisher's exact test), Q value = 1
Table S24. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
NRAS MUTATED | 0 | 5 | 1 | 13 |
NRAS WILD-TYPE | 7 | 23 | 16 | 155 |
P value = 1 (Fisher's exact test), Q value = 1
Table S25. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
NRAS MUTATED | 0 | 19 | 0 |
NRAS WILD-TYPE | 5 | 194 | 2 |
P value = 0.268 (Fisher's exact test), Q value = 1
Table S26. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
NRAS MUTATED | 1 | 0 | 17 |
NRAS WILD-TYPE | 2 | 9 | 177 |
P value = 1 (Fisher's exact test), Q value = 1
Table S27. Gene #3: 'NRAS MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
NRAS MUTATED | 0 | 0 | 18 |
NRAS WILD-TYPE | 8 | 2 | 178 |
P value = 2.84e-06 (Fisher's exact test), Q value = 0.00059
Table S28. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
BRAF MUTATED | 13 | 1 | 1 | 5 |
BRAF WILD-TYPE | 29 | 56 | 66 | 34 |
Figure S9. Get High-res Image Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D4V1.png)
P value = 1.41e-07 (Fisher's exact test), Q value = 3e-05
Table S29. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
BRAF MUTATED | 1 | 0 | 18 | 1 |
BRAF WILD-TYPE | 39 | 48 | 43 | 55 |
Figure S10. Get High-res Image Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D4V2.png)
P value = 0.000332 (Fisher's exact test), Q value = 0.067
Table S30. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
BRAF MUTATED | 1 | 18 | 3 | 0 |
BRAF WILD-TYPE | 68 | 67 | 59 | 4 |
Figure S11. Get High-res Image Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D4V3.png)
P value = 0.482 (Fisher's exact test), Q value = 1
Table S31. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
BRAF MUTATED | 3 | 4 | 4 | 2 |
BRAF WILD-TYPE | 37 | 63 | 20 | 24 |
P value = 0.304 (Fisher's exact test), Q value = 1
Table S32. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
BRAF MUTATED | 1 | 8 | 2 | 2 |
BRAF WILD-TYPE | 19 | 101 | 17 | 7 |
P value = 0.371 (Fisher's exact test), Q value = 1
Table S33. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
BRAF MUTATED | 1 | 4 | 0 | 17 |
BRAF WILD-TYPE | 6 | 24 | 17 | 151 |
P value = 0.527 (Fisher's exact test), Q value = 1
Table S34. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
BRAF MUTATED | 1 | 21 | 0 |
BRAF WILD-TYPE | 4 | 192 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S35. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
BRAF MUTATED | 0 | 1 | 21 |
BRAF WILD-TYPE | 3 | 8 | 173 |
P value = 0.684 (Fisher's exact test), Q value = 1
Table S36. Gene #4: 'BRAF MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
BRAF MUTATED | 0 | 0 | 22 |
BRAF WILD-TYPE | 8 | 2 | 174 |
P value = 7.86e-05 (Fisher's exact test), Q value = 0.016
Table S37. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
KRAS MUTATED | 13 | 14 | 31 | 27 |
KRAS WILD-TYPE | 29 | 43 | 36 | 12 |
Figure S12. Get High-res Image Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D5V1.png)
P value = 4.23e-05 (Fisher's exact test), Q value = 0.0088
Table S38. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
KRAS MUTATED | 10 | 33 | 26 | 16 |
KRAS WILD-TYPE | 30 | 15 | 35 | 40 |
Figure S13. Get High-res Image Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D5V2.png)
P value = 0.322 (Fisher's exact test), Q value = 1
Table S39. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
KRAS MUTATED | 25 | 40 | 27 | 3 |
KRAS WILD-TYPE | 44 | 45 | 35 | 1 |
P value = 0.107 (Fisher's exact test), Q value = 1
Table S40. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #4: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 2 | 1 |
KRAS MUTATED | 1 | 2 | 0 |
KRAS WILD-TYPE | 4 | 0 | 1 |
P value = 0.565 (Fisher's exact test), Q value = 1
Table S41. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
KRAS MUTATED | 16 | 34 | 9 | 13 |
KRAS WILD-TYPE | 24 | 33 | 15 | 13 |
P value = 1 (Fisher's exact test), Q value = 1
Table S42. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
KRAS MUTATED | 9 | 50 | 9 | 4 |
KRAS WILD-TYPE | 11 | 59 | 10 | 5 |
P value = 0.00015 (Fisher's exact test), Q value = 0.031
Table S43. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
KRAS MUTATED | 3 | 21 | 2 | 67 |
KRAS WILD-TYPE | 4 | 7 | 15 | 101 |
Figure S14. Get High-res Image Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
![](D5V7.png)
P value = 0.829 (Fisher's exact test), Q value = 1
Table S44. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
KRAS MUTATED | 3 | 89 | 1 |
KRAS WILD-TYPE | 2 | 124 | 1 |
P value = 0.0218 (Fisher's exact test), Q value = 1
Table S45. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
KRAS MUTATED | 0 | 7 | 79 |
KRAS WILD-TYPE | 3 | 2 | 115 |
Figure S15. Get High-res Image Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
![](D5V9.png)
P value = 0.0431 (Fisher's exact test), Q value = 1
Table S46. Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
KRAS MUTATED | 1 | 2 | 83 |
KRAS WILD-TYPE | 7 | 0 | 113 |
Figure S16. Get High-res Image Gene #5: 'KRAS MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
![](D5V10.png)
P value = 0.00206 (Fisher's exact test), Q value = 0.41
Table S47. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
TP53 MUTATED | 17 | 40 | 39 | 14 |
TP53 WILD-TYPE | 25 | 17 | 28 | 25 |
Figure S17. Get High-res Image Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D6V1.png)
P value = 0.000493 (Fisher's exact test), Q value = 0.1
Table S48. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
TP53 MUTATED | 30 | 19 | 25 | 36 |
TP53 WILD-TYPE | 10 | 29 | 36 | 20 |
Figure S18. Get High-res Image Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D6V2.png)
P value = 1.15e-10 (Fisher's exact test), Q value = 2.4e-08
Table S49. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
TP53 MUTATED | 55 | 23 | 38 | 1 |
TP53 WILD-TYPE | 14 | 62 | 24 | 3 |
Figure S19. Get High-res Image Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D6V3.png)
P value = 0.562 (Fisher's exact test), Q value = 1
Table S50. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
TP53 MUTATED | 18 | 34 | 15 | 12 |
TP53 WILD-TYPE | 22 | 33 | 9 | 14 |
P value = 0.755 (Fisher's exact test), Q value = 1
Table S51. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
TP53 MUTATED | 8 | 57 | 9 | 5 |
TP53 WILD-TYPE | 12 | 52 | 10 | 4 |
P value = 0.014 (Fisher's exact test), Q value = 1
Table S52. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
TP53 MUTATED | 2 | 8 | 11 | 96 |
TP53 WILD-TYPE | 5 | 20 | 6 | 72 |
Figure S20. Get High-res Image Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
![](D6V7.png)
P value = 1 (Fisher's exact test), Q value = 1
Table S53. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
TP53 MUTATED | 3 | 113 | 1 |
TP53 WILD-TYPE | 2 | 100 | 1 |
P value = 0.0307 (Fisher's exact test), Q value = 1
Table S54. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
TP53 MUTATED | 3 | 2 | 106 |
TP53 WILD-TYPE | 0 | 7 | 88 |
Figure S21. Get High-res Image Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
![](D6V9.png)
P value = 0.567 (Fisher's exact test), Q value = 1
Table S55. Gene #6: 'TP53 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
TP53 MUTATED | 6 | 1 | 104 |
TP53 WILD-TYPE | 2 | 1 | 92 |
P value = 0.0322 (Fisher's exact test), Q value = 1
Table S56. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
SMAD4 MUTATED | 7 | 4 | 4 | 9 |
SMAD4 WILD-TYPE | 35 | 53 | 63 | 30 |
Figure S22. Get High-res Image Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D7V1.png)
P value = 0.289 (Fisher's exact test), Q value = 1
Table S57. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
SMAD4 MUTATED | 5 | 6 | 10 | 3 |
SMAD4 WILD-TYPE | 35 | 42 | 51 | 53 |
P value = 0.0646 (Fisher's exact test), Q value = 1
Table S58. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
SMAD4 MUTATED | 3 | 15 | 8 | 0 |
SMAD4 WILD-TYPE | 66 | 70 | 54 | 4 |
P value = 0.827 (Fisher's exact test), Q value = 1
Table S59. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
SMAD4 MUTATED | 4 | 10 | 4 | 3 |
SMAD4 WILD-TYPE | 36 | 57 | 20 | 23 |
P value = 0.339 (Fisher's exact test), Q value = 1
Table S60. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
SMAD4 MUTATED | 2 | 14 | 2 | 3 |
SMAD4 WILD-TYPE | 18 | 95 | 17 | 6 |
P value = 0.417 (Fisher's exact test), Q value = 1
Table S61. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
SMAD4 MUTATED | 1 | 4 | 0 | 20 |
SMAD4 WILD-TYPE | 6 | 24 | 17 | 148 |
P value = 1 (Fisher's exact test), Q value = 1
Table S62. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
SMAD4 MUTATED | 0 | 25 | 0 |
SMAD4 WILD-TYPE | 5 | 188 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S63. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
SMAD4 MUTATED | 0 | 1 | 24 |
SMAD4 WILD-TYPE | 3 | 8 | 170 |
P value = 1 (Fisher's exact test), Q value = 1
Table S64. Gene #7: 'SMAD4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
SMAD4 MUTATED | 1 | 0 | 24 |
SMAD4 WILD-TYPE | 7 | 2 | 172 |
P value = 0.0787 (Fisher's exact test), Q value = 1
Table S65. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
FAM123B MUTATED | 9 | 5 | 4 | 6 |
FAM123B WILD-TYPE | 33 | 52 | 63 | 33 |
P value = 0.0924 (Fisher's exact test), Q value = 1
Table S66. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
FAM123B MUTATED | 2 | 3 | 12 | 7 |
FAM123B WILD-TYPE | 38 | 45 | 49 | 49 |
P value = 0.00912 (Fisher's exact test), Q value = 1
Table S67. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
FAM123B MUTATED | 5 | 17 | 2 | 0 |
FAM123B WILD-TYPE | 64 | 68 | 60 | 4 |
Figure S23. Get High-res Image Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D8V3.png)
P value = 0.345 (Fisher's exact test), Q value = 1
Table S68. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
FAM123B MUTATED | 2 | 7 | 2 | 5 |
FAM123B WILD-TYPE | 38 | 60 | 22 | 21 |
P value = 0.588 (Fisher's exact test), Q value = 1
Table S69. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
FAM123B MUTATED | 1 | 12 | 3 | 0 |
FAM123B WILD-TYPE | 19 | 97 | 16 | 9 |
P value = 0.0941 (Fisher's exact test), Q value = 1
Table S70. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
FAM123B MUTATED | 1 | 7 | 1 | 16 |
FAM123B WILD-TYPE | 6 | 21 | 16 | 152 |
P value = 1 (Fisher's exact test), Q value = 1
Table S71. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
FAM123B MUTATED | 0 | 25 | 0 |
FAM123B WILD-TYPE | 5 | 188 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S72. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
FAM123B MUTATED | 0 | 1 | 23 |
FAM123B WILD-TYPE | 3 | 8 | 171 |
P value = 1 (Fisher's exact test), Q value = 1
Table S73. Gene #8: 'FAM123B MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
FAM123B MUTATED | 1 | 0 | 23 |
FAM123B WILD-TYPE | 7 | 2 | 173 |
P value = 0.208 (Fisher's exact test), Q value = 1
Table S74. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
PIK3CA MUTATED | 8 | 4 | 7 | 7 |
PIK3CA WILD-TYPE | 34 | 53 | 60 | 32 |
P value = 0.569 (Fisher's exact test), Q value = 1
Table S75. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
PIK3CA MUTATED | 3 | 7 | 10 | 6 |
PIK3CA WILD-TYPE | 37 | 41 | 51 | 50 |
P value = 0.00032 (Fisher's exact test), Q value = 0.065
Table S76. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
PIK3CA MUTATED | 4 | 23 | 4 | 1 |
PIK3CA WILD-TYPE | 65 | 62 | 58 | 3 |
Figure S24. Get High-res Image Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D9V3.png)
P value = 0.0673 (Fisher's exact test), Q value = 1
Table S77. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
PIK3CA MUTATED | 11 | 9 | 1 | 6 |
PIK3CA WILD-TYPE | 29 | 58 | 23 | 20 |
P value = 0.129 (Fisher's exact test), Q value = 1
Table S78. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
PIK3CA MUTATED | 6 | 16 | 5 | 0 |
PIK3CA WILD-TYPE | 14 | 93 | 14 | 9 |
P value = 0.0279 (Fisher's exact test), Q value = 1
Table S79. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
PIK3CA MUTATED | 2 | 8 | 0 | 23 |
PIK3CA WILD-TYPE | 5 | 20 | 17 | 145 |
Figure S25. Get High-res Image Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
![](D9V7.png)
P value = 0.685 (Fisher's exact test), Q value = 1
Table S80. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
PIK3CA MUTATED | 1 | 32 | 0 |
PIK3CA WILD-TYPE | 4 | 181 | 2 |
P value = 0.165 (Fisher's exact test), Q value = 1
Table S81. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
PIK3CA MUTATED | 0 | 3 | 26 |
PIK3CA WILD-TYPE | 3 | 6 | 168 |
P value = 1 (Fisher's exact test), Q value = 1
Table S82. Gene #9: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
PIK3CA MUTATED | 1 | 0 | 28 |
PIK3CA WILD-TYPE | 7 | 2 | 168 |
P value = 0.134 (Fisher's exact test), Q value = 1
Table S83. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
SMAD2 MUTATED | 4 | 2 | 2 | 5 |
SMAD2 WILD-TYPE | 38 | 55 | 65 | 34 |
P value = 0.518 (Fisher's exact test), Q value = 1
Table S84. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
SMAD2 MUTATED | 3 | 2 | 6 | 2 |
SMAD2 WILD-TYPE | 37 | 46 | 55 | 54 |
P value = 0.161 (Fisher's exact test), Q value = 1
Table S85. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
SMAD2 MUTATED | 2 | 10 | 3 | 0 |
SMAD2 WILD-TYPE | 67 | 75 | 59 | 4 |
P value = 0.592 (Fisher's exact test), Q value = 1
Table S86. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
SMAD2 MUTATED | 2 | 3 | 2 | 3 |
SMAD2 WILD-TYPE | 38 | 64 | 22 | 23 |
P value = 0.133 (Fisher's exact test), Q value = 1
Table S87. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
SMAD2 MUTATED | 0 | 6 | 3 | 1 |
SMAD2 WILD-TYPE | 20 | 103 | 16 | 8 |
P value = 0.57 (Fisher's exact test), Q value = 1
Table S88. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
SMAD2 MUTATED | 0 | 3 | 0 | 12 |
SMAD2 WILD-TYPE | 7 | 25 | 17 | 156 |
P value = 1 (Fisher's exact test), Q value = 1
Table S89. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
SMAD2 MUTATED | 0 | 15 | 0 |
SMAD2 WILD-TYPE | 5 | 198 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S90. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
SMAD2 MUTATED | 0 | 0 | 14 |
SMAD2 WILD-TYPE | 3 | 9 | 180 |
P value = 1 (Fisher's exact test), Q value = 1
Table S91. Gene #10: 'SMAD2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
SMAD2 MUTATED | 0 | 0 | 14 |
SMAD2 WILD-TYPE | 8 | 2 | 182 |
P value = 1 (Fisher's exact test), Q value = 1
Table S92. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
TCF7L2 MUTATED | 3 | 4 | 5 | 3 |
TCF7L2 WILD-TYPE | 39 | 53 | 62 | 36 |
P value = 0.416 (Fisher's exact test), Q value = 1
Table S93. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
TCF7L2 MUTATED | 4 | 5 | 2 | 4 |
TCF7L2 WILD-TYPE | 36 | 43 | 59 | 52 |
P value = 0.00239 (Fisher's exact test), Q value = 0.48
Table S94. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
TCF7L2 MUTATED | 7 | 6 | 2 | 3 |
TCF7L2 WILD-TYPE | 62 | 79 | 60 | 1 |
Figure S26. Get High-res Image Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D11V3.png)
P value = 0.836 (Fisher's exact test), Q value = 1
Table S95. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
TCF7L2 MUTATED | 3 | 5 | 1 | 3 |
TCF7L2 WILD-TYPE | 37 | 62 | 23 | 23 |
P value = 0.896 (Fisher's exact test), Q value = 1
Table S96. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
TCF7L2 MUTATED | 1 | 9 | 2 | 0 |
TCF7L2 WILD-TYPE | 19 | 100 | 17 | 9 |
P value = 0.334 (Fisher's exact test), Q value = 1
Table S97. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
TCF7L2 MUTATED | 0 | 0 | 1 | 16 |
TCF7L2 WILD-TYPE | 7 | 28 | 16 | 152 |
P value = 1 (Fisher's exact test), Q value = 1
Table S98. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
TCF7L2 MUTATED | 0 | 17 | 0 |
TCF7L2 WILD-TYPE | 5 | 196 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S99. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
TCF7L2 MUTATED | 0 | 0 | 15 |
TCF7L2 WILD-TYPE | 3 | 9 | 179 |
P value = 1 (Fisher's exact test), Q value = 1
Table S100. Gene #11: 'TCF7L2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
TCF7L2 MUTATED | 0 | 0 | 15 |
TCF7L2 WILD-TYPE | 8 | 2 | 181 |
P value = 0.00717 (Fisher's exact test), Q value = 1
Table S101. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
ACVR2A MUTATED | 5 | 1 | 0 | 2 |
ACVR2A WILD-TYPE | 37 | 56 | 67 | 37 |
Figure S27. Get High-res Image Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D12V1.png)
P value = 0.184 (Fisher's exact test), Q value = 1
Table S102. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
ACVR2A MUTATED | 1 | 0 | 5 | 2 |
ACVR2A WILD-TYPE | 39 | 48 | 56 | 54 |
P value = 0.0236 (Fisher's exact test), Q value = 1
Table S103. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
ACVR2A MUTATED | 1 | 8 | 0 | 0 |
ACVR2A WILD-TYPE | 68 | 77 | 62 | 4 |
Figure S28. Get High-res Image Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D12V3.png)
P value = 0.0952 (Fisher's exact test), Q value = 1
Table S104. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
ACVR2A MUTATED | 0 | 4 | 0 | 3 |
ACVR2A WILD-TYPE | 40 | 63 | 24 | 23 |
P value = 0.469 (Fisher's exact test), Q value = 1
Table S105. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
ACVR2A MUTATED | 0 | 5 | 2 | 0 |
ACVR2A WILD-TYPE | 20 | 104 | 17 | 9 |
P value = 0.868 (Fisher's exact test), Q value = 1
Table S106. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
ACVR2A MUTATED | 0 | 1 | 1 | 7 |
ACVR2A WILD-TYPE | 7 | 27 | 16 | 161 |
P value = 1 (Fisher's exact test), Q value = 1
Table S107. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
ACVR2A MUTATED | 0 | 9 | 0 |
ACVR2A WILD-TYPE | 5 | 204 | 2 |
P value = 0.173 (Fisher's exact test), Q value = 1
Table S108. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
ACVR2A MUTATED | 1 | 0 | 8 |
ACVR2A WILD-TYPE | 2 | 9 | 186 |
P value = 1 (Fisher's exact test), Q value = 1
Table S109. Gene #12: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
ACVR2A MUTATED | 0 | 0 | 9 |
ACVR2A WILD-TYPE | 8 | 2 | 187 |
P value = 0.129 (Fisher's exact test), Q value = 1
Table S110. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
SOX9 MUTATED | 2 | 1 | 6 | 0 |
SOX9 WILD-TYPE | 40 | 56 | 61 | 39 |
P value = 0.123 (Fisher's exact test), Q value = 1
Table S111. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
SOX9 MUTATED | 2 | 5 | 1 | 1 |
SOX9 WILD-TYPE | 38 | 43 | 60 | 55 |
P value = 0.00856 (Fisher's exact test), Q value = 1
Table S112. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
SOX9 MUTATED | 0 | 9 | 1 | 0 |
SOX9 WILD-TYPE | 69 | 76 | 61 | 4 |
Figure S29. Get High-res Image Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D13V3.png)
P value = 0.189 (Fisher's exact test), Q value = 1
Table S113. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
SOX9 MUTATED | 0 | 3 | 0 | 2 |
SOX9 WILD-TYPE | 40 | 64 | 24 | 24 |
P value = 0.694 (Fisher's exact test), Q value = 1
Table S114. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
SOX9 MUTATED | 0 | 4 | 1 | 0 |
SOX9 WILD-TYPE | 20 | 105 | 18 | 9 |
P value = 0.782 (Fisher's exact test), Q value = 1
Table S115. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
SOX9 MUTATED | 0 | 2 | 0 | 8 |
SOX9 WILD-TYPE | 7 | 26 | 17 | 160 |
P value = 1 (Fisher's exact test), Q value = 1
Table S116. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
SOX9 MUTATED | 0 | 10 | 0 |
SOX9 WILD-TYPE | 5 | 203 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S117. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
SOX9 MUTATED | 0 | 0 | 10 |
SOX9 WILD-TYPE | 3 | 9 | 184 |
P value = 1 (Fisher's exact test), Q value = 1
Table S118. Gene #13: 'SOX9 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
SOX9 MUTATED | 0 | 0 | 10 |
SOX9 WILD-TYPE | 8 | 2 | 186 |
P value = 0.363 (Fisher's exact test), Q value = 1
Table S119. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
ELF3 MUTATED | 1 | 0 | 3 | 2 |
ELF3 WILD-TYPE | 41 | 57 | 64 | 37 |
P value = 0.811 (Fisher's exact test), Q value = 1
Table S120. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
ELF3 MUTATED | 2 | 1 | 2 | 1 |
ELF3 WILD-TYPE | 38 | 47 | 59 | 55 |
P value = 0.273 (Fisher's exact test), Q value = 1
Table S121. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
ELF3 MUTATED | 0 | 3 | 3 | 0 |
ELF3 WILD-TYPE | 69 | 82 | 59 | 4 |
P value = 0.544 (Fisher's exact test), Q value = 1
Table S122. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
ELF3 MUTATED | 2 | 1 | 0 | 1 |
ELF3 WILD-TYPE | 38 | 66 | 24 | 25 |
P value = 0.436 (Fisher's exact test), Q value = 1
Table S123. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
ELF3 MUTATED | 1 | 2 | 1 | 0 |
ELF3 WILD-TYPE | 19 | 107 | 18 | 9 |
P value = 0.014 (Fisher's exact test), Q value = 1
Table S124. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
ELF3 MUTATED | 1 | 3 | 0 | 2 |
ELF3 WILD-TYPE | 6 | 25 | 17 | 166 |
Figure S30. Get High-res Image Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
![](D14V7.png)
P value = 0.178 (Fisher's exact test), Q value = 1
Table S125. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
ELF3 MUTATED | 1 | 5 | 0 |
ELF3 WILD-TYPE | 4 | 208 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S126. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
ELF3 MUTATED | 0 | 0 | 6 |
ELF3 WILD-TYPE | 3 | 9 | 188 |
P value = 1 (Fisher's exact test), Q value = 1
Table S127. Gene #14: 'ELF3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
ELF3 MUTATED | 0 | 0 | 6 |
ELF3 WILD-TYPE | 8 | 2 | 190 |
P value = 0.123 (Fisher's exact test), Q value = 1
Table S128. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
CRTC1 MUTATED | 2 | 0 | 4 | 0 |
CRTC1 WILD-TYPE | 40 | 57 | 63 | 39 |
P value = 0.165 (Fisher's exact test), Q value = 1
Table S129. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
CRTC1 MUTATED | 3 | 1 | 2 | 0 |
CRTC1 WILD-TYPE | 37 | 47 | 59 | 56 |
P value = 0.273 (Fisher's exact test), Q value = 1
Table S130. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
CRTC1 MUTATED | 0 | 3 | 3 | 0 |
CRTC1 WILD-TYPE | 69 | 82 | 59 | 4 |
P value = 0.175 (Fisher's exact test), Q value = 1
Table S131. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
CRTC1 MUTATED | 2 | 0 | 0 | 1 |
CRTC1 WILD-TYPE | 38 | 67 | 24 | 25 |
P value = 0.482 (Fisher's exact test), Q value = 1
Table S132. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
CRTC1 MUTATED | 0 | 2 | 1 | 0 |
CRTC1 WILD-TYPE | 20 | 107 | 18 | 9 |
P value = 1 (Fisher's exact test), Q value = 1
Table S133. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
CRTC1 MUTATED | 0 | 1 | 0 | 5 |
CRTC1 WILD-TYPE | 7 | 27 | 17 | 163 |
P value = 1 (Fisher's exact test), Q value = 1
Table S134. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
CRTC1 MUTATED | 0 | 6 | 0 |
CRTC1 WILD-TYPE | 5 | 207 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S135. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
CRTC1 MUTATED | 0 | 0 | 6 |
CRTC1 WILD-TYPE | 3 | 9 | 188 |
P value = 1 (Fisher's exact test), Q value = 1
Table S136. Gene #15: 'CRTC1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
CRTC1 MUTATED | 0 | 0 | 6 |
CRTC1 WILD-TYPE | 8 | 2 | 190 |
P value = 0.317 (Fisher's exact test), Q value = 1
Table S137. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
TNFRSF10C MUTATED | 3 | 1 | 2 | 0 |
TNFRSF10C WILD-TYPE | 39 | 56 | 65 | 39 |
P value = 0.287 (Fisher's exact test), Q value = 1
Table S138. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
TNFRSF10C MUTATED | 1 | 3 | 2 | 0 |
TNFRSF10C WILD-TYPE | 39 | 45 | 59 | 56 |
P value = 0.707 (Fisher's exact test), Q value = 1
Table S139. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
TNFRSF10C MUTATED | 3 | 2 | 1 | 0 |
TNFRSF10C WILD-TYPE | 66 | 83 | 61 | 4 |
P value = 0.278 (Fisher's exact test), Q value = 1
Table S140. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
TNFRSF10C MUTATED | 3 | 1 | 0 | 1 |
TNFRSF10C WILD-TYPE | 37 | 66 | 24 | 25 |
P value = 0.378 (Fisher's exact test), Q value = 1
Table S141. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
TNFRSF10C MUTATED | 2 | 3 | 0 | 0 |
TNFRSF10C WILD-TYPE | 18 | 106 | 19 | 9 |
P value = 0.248 (Fisher's exact test), Q value = 1
Table S142. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
TNFRSF10C MUTATED | 1 | 1 | 0 | 4 |
TNFRSF10C WILD-TYPE | 6 | 27 | 17 | 164 |
P value = 1 (Fisher's exact test), Q value = 1
Table S143. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
TNFRSF10C MUTATED | 0 | 6 | 0 |
TNFRSF10C WILD-TYPE | 5 | 207 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S144. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
TNFRSF10C MUTATED | 0 | 0 | 6 |
TNFRSF10C WILD-TYPE | 3 | 9 | 188 |
P value = 1 (Fisher's exact test), Q value = 1
Table S145. Gene #16: 'TNFRSF10C MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
TNFRSF10C MUTATED | 0 | 0 | 6 |
TNFRSF10C WILD-TYPE | 8 | 2 | 190 |
P value = 0.271 (Fisher's exact test), Q value = 1
Table S146. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
KIAA1804 MUTATED | 3 | 1 | 6 | 4 |
KIAA1804 WILD-TYPE | 39 | 56 | 61 | 35 |
P value = 0.394 (Fisher's exact test), Q value = 1
Table S147. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
KIAA1804 MUTATED | 4 | 2 | 6 | 2 |
KIAA1804 WILD-TYPE | 36 | 46 | 55 | 54 |
P value = 0.028 (Fisher's exact test), Q value = 1
Table S148. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
KIAA1804 MUTATED | 3 | 10 | 1 | 1 |
KIAA1804 WILD-TYPE | 66 | 75 | 61 | 3 |
Figure S31. Get High-res Image Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D17V3.png)
P value = 0.506 (Fisher's exact test), Q value = 1
Table S149. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
KIAA1804 MUTATED | 2 | 6 | 1 | 4 |
KIAA1804 WILD-TYPE | 38 | 61 | 23 | 22 |
P value = 0.474 (Fisher's exact test), Q value = 1
Table S150. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
KIAA1804 MUTATED | 0 | 11 | 2 | 0 |
KIAA1804 WILD-TYPE | 20 | 98 | 17 | 9 |
P value = 0.57 (Fisher's exact test), Q value = 1
Table S151. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
KIAA1804 MUTATED | 0 | 3 | 0 | 12 |
KIAA1804 WILD-TYPE | 7 | 25 | 17 | 156 |
P value = 1 (Fisher's exact test), Q value = 1
Table S152. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
KIAA1804 MUTATED | 0 | 15 | 0 |
KIAA1804 WILD-TYPE | 5 | 198 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S153. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
KIAA1804 MUTATED | 0 | 0 | 15 |
KIAA1804 WILD-TYPE | 3 | 9 | 179 |
P value = 1 (Fisher's exact test), Q value = 1
Table S154. Gene #17: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
KIAA1804 MUTATED | 0 | 0 | 15 |
KIAA1804 WILD-TYPE | 8 | 2 | 181 |
P value = 0.327 (Fisher's exact test), Q value = 1
Table S155. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
KRTAP5-5 MUTATED | 1 | 0 | 3 | 0 |
KRTAP5-5 WILD-TYPE | 41 | 57 | 64 | 39 |
P value = 0.482 (Fisher's exact test), Q value = 1
Table S156. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
KRTAP5-5 MUTATED | 1 | 2 | 1 | 0 |
KRTAP5-5 WILD-TYPE | 39 | 46 | 60 | 56 |
P value = 0.839 (Fisher's exact test), Q value = 1
Table S157. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
KRTAP5-5 MUTATED | 2 | 1 | 1 | 0 |
KRTAP5-5 WILD-TYPE | 67 | 84 | 61 | 4 |
P value = 0.385 (Fisher's exact test), Q value = 1
Table S158. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
KRTAP5-5 MUTATED | 0 | 3 | 1 | 0 |
KRTAP5-5 WILD-TYPE | 40 | 64 | 23 | 26 |
P value = 1 (Fisher's exact test), Q value = 1
Table S159. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
KRTAP5-5 MUTATED | 0 | 4 | 0 | 0 |
KRTAP5-5 WILD-TYPE | 20 | 105 | 19 | 9 |
P value = 1 (Fisher's exact test), Q value = 1
Table S160. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
KRTAP5-5 MUTATED | 0 | 0 | 0 | 4 |
KRTAP5-5 WILD-TYPE | 7 | 28 | 17 | 164 |
P value = 1 (Fisher's exact test), Q value = 1
Table S161. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
KRTAP5-5 MUTATED | 0 | 4 | 0 |
KRTAP5-5 WILD-TYPE | 5 | 209 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S162. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
KRTAP5-5 MUTATED | 0 | 0 | 3 |
KRTAP5-5 WILD-TYPE | 3 | 9 | 191 |
P value = 1 (Fisher's exact test), Q value = 1
Table S163. Gene #18: 'KRTAP5-5 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
KRTAP5-5 MUTATED | 0 | 0 | 3 |
KRTAP5-5 WILD-TYPE | 8 | 2 | 193 |
P value = 0.0276 (Fisher's exact test), Q value = 1
Table S164. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
PTEN MUTATED | 2 | 0 | 1 | 4 |
PTEN WILD-TYPE | 40 | 57 | 66 | 35 |
Figure S32. Get High-res Image Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D19V1.png)
P value = 0.337 (Fisher's exact test), Q value = 1
Table S165. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
PTEN MUTATED | 1 | 0 | 4 | 2 |
PTEN WILD-TYPE | 39 | 48 | 57 | 54 |
P value = 0.07 (Fisher's exact test), Q value = 1
Table S166. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
PTEN MUTATED | 0 | 6 | 1 | 0 |
PTEN WILD-TYPE | 69 | 79 | 61 | 4 |
P value = 0.544 (Fisher's exact test), Q value = 1
Table S167. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
PTEN MUTATED | 2 | 1 | 0 | 1 |
PTEN WILD-TYPE | 38 | 66 | 24 | 25 |
P value = 0.436 (Fisher's exact test), Q value = 1
Table S168. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
PTEN MUTATED | 1 | 2 | 1 | 0 |
PTEN WILD-TYPE | 19 | 107 | 18 | 9 |
P value = 0.098 (Fisher's exact test), Q value = 1
Table S169. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
PTEN MUTATED | 1 | 2 | 0 | 4 |
PTEN WILD-TYPE | 6 | 26 | 17 | 164 |
P value = 1 (Fisher's exact test), Q value = 1
Table S170. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
PTEN MUTATED | 0 | 7 | 0 |
PTEN WILD-TYPE | 5 | 206 | 2 |
P value = 0.347 (Fisher's exact test), Q value = 1
Table S171. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
PTEN MUTATED | 0 | 1 | 6 |
PTEN WILD-TYPE | 3 | 8 | 188 |
P value = 0.298 (Fisher's exact test), Q value = 1
Table S172. Gene #19: 'PTEN MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
PTEN MUTATED | 1 | 0 | 6 |
PTEN WILD-TYPE | 7 | 2 | 190 |
P value = 0.255 (Fisher's exact test), Q value = 1
Table S173. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
ACOT4 MUTATED | 2 | 0 | 1 | 0 |
ACOT4 WILD-TYPE | 40 | 57 | 66 | 39 |
P value = 0.49 (Fisher's exact test), Q value = 1
Table S174. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
ACOT4 MUTATED | 0 | 1 | 2 | 0 |
ACOT4 WILD-TYPE | 40 | 47 | 59 | 56 |
P value = 0.792 (Fisher's exact test), Q value = 1
Table S175. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
ACOT4 MUTATED | 1 | 2 | 0 | 0 |
ACOT4 WILD-TYPE | 68 | 83 | 62 | 4 |
P value = 0.557 (Fisher's exact test), Q value = 1
Table S176. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
ACOT4 MUTATED | 0 | 1 | 0 | 2 |
ACOT4 WILD-TYPE | 7 | 27 | 17 | 166 |
P value = 1 (Fisher's exact test), Q value = 1
Table S177. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
ACOT4 MUTATED | 0 | 3 | 0 |
ACOT4 WILD-TYPE | 5 | 210 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S178. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
ACOT4 MUTATED | 0 | 0 | 3 |
ACOT4 WILD-TYPE | 3 | 9 | 191 |
P value = 1 (Fisher's exact test), Q value = 1
Table S179. Gene #20: 'ACOT4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
ACOT4 MUTATED | 0 | 0 | 3 |
ACOT4 WILD-TYPE | 8 | 2 | 193 |
P value = 0.00868 (Fisher's exact test), Q value = 1
Table S180. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
MYO1B MUTATED | 6 | 1 | 1 | 4 |
MYO1B WILD-TYPE | 36 | 56 | 66 | 35 |
Figure S33. Get High-res Image Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
![](D21V1.png)
P value = 0.00887 (Fisher's exact test), Q value = 1
Table S181. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
MYO1B MUTATED | 3 | 0 | 8 | 1 |
MYO1B WILD-TYPE | 37 | 48 | 53 | 55 |
Figure S34. Get High-res Image Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
![](D21V2.png)
P value = 0.00479 (Fisher's exact test), Q value = 0.95
Table S182. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
MYO1B MUTATED | 2 | 11 | 0 | 0 |
MYO1B WILD-TYPE | 67 | 74 | 62 | 4 |
Figure S35. Get High-res Image Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
![](D21V3.png)
P value = 0.0215 (Fisher's exact test), Q value = 1
Table S183. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
MYO1B MUTATED | 3 | 0 | 1 | 3 |
MYO1B WILD-TYPE | 37 | 67 | 23 | 23 |
Figure S36. Get High-res Image Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
![](D21V5.png)
P value = 0.469 (Fisher's exact test), Q value = 1
Table S184. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
MYO1B MUTATED | 0 | 5 | 2 | 0 |
MYO1B WILD-TYPE | 20 | 104 | 17 | 9 |
P value = 0.187 (Fisher's exact test), Q value = 1
Table S185. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
MYO1B MUTATED | 0 | 4 | 1 | 8 |
MYO1B WILD-TYPE | 7 | 24 | 16 | 160 |
P value = 0.351 (Fisher's exact test), Q value = 1
Table S186. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
MYO1B MUTATED | 1 | 12 | 0 |
MYO1B WILD-TYPE | 4 | 201 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S187. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
MYO1B MUTATED | 0 | 0 | 12 |
MYO1B WILD-TYPE | 3 | 9 | 182 |
P value = 1 (Fisher's exact test), Q value = 1
Table S188. Gene #21: 'MYO1B MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
MYO1B MUTATED | 0 | 0 | 12 |
MYO1B WILD-TYPE | 8 | 2 | 184 |
P value = 0.234 (Fisher's exact test), Q value = 1
Table S189. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
PCBP1 MUTATED | 0 | 1 | 2 | 3 |
PCBP1 WILD-TYPE | 42 | 56 | 65 | 36 |
P value = 0.811 (Fisher's exact test), Q value = 1
Table S190. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
PCBP1 MUTATED | 2 | 1 | 2 | 1 |
PCBP1 WILD-TYPE | 38 | 47 | 59 | 55 |
P value = 0.795 (Fisher's exact test), Q value = 1
Table S191. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
PCBP1 MUTATED | 1 | 3 | 2 | 0 |
PCBP1 WILD-TYPE | 68 | 82 | 60 | 4 |
P value = 0.648 (Fisher's exact test), Q value = 1
Table S192. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
PCBP1 MUTATED | 0 | 2 | 0 | 1 |
PCBP1 WILD-TYPE | 40 | 65 | 24 | 25 |
P value = 0.482 (Fisher's exact test), Q value = 1
Table S193. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
PCBP1 MUTATED | 0 | 2 | 1 | 0 |
PCBP1 WILD-TYPE | 20 | 107 | 18 | 9 |
P value = 0.8 (Fisher's exact test), Q value = 1
Table S194. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
PCBP1 MUTATED | 0 | 0 | 0 | 6 |
PCBP1 WILD-TYPE | 7 | 28 | 17 | 162 |
P value = 1 (Fisher's exact test), Q value = 1
Table S195. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
PCBP1 MUTATED | 0 | 6 | 0 |
PCBP1 WILD-TYPE | 5 | 207 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S196. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
PCBP1 MUTATED | 0 | 0 | 5 |
PCBP1 WILD-TYPE | 3 | 9 | 189 |
P value = 1 (Fisher's exact test), Q value = 1
Table S197. Gene #22: 'PCBP1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
PCBP1 MUTATED | 0 | 0 | 5 |
PCBP1 WILD-TYPE | 8 | 2 | 191 |
P value = 0.162 (Fisher's exact test), Q value = 1
Table S198. Gene #23: 'GGT1 MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
GGT1 MUTATED | 0 | 3 | 0 | 0 |
GGT1 WILD-TYPE | 69 | 82 | 62 | 4 |
P value = 0.557 (Fisher's exact test), Q value = 1
Table S199. Gene #23: 'GGT1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
GGT1 MUTATED | 0 | 1 | 0 | 2 |
GGT1 WILD-TYPE | 7 | 27 | 17 | 166 |
P value = 1 (Fisher's exact test), Q value = 1
Table S200. Gene #23: 'GGT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
GGT1 MUTATED | 0 | 3 | 0 |
GGT1 WILD-TYPE | 5 | 210 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
Table S201. Gene #23: 'GGT1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
GGT1 MUTATED | 0 | 0 | 3 |
GGT1 WILD-TYPE | 3 | 9 | 191 |
P value = 1 (Fisher's exact test), Q value = 1
Table S202. Gene #23: 'GGT1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
GGT1 MUTATED | 0 | 0 | 3 |
GGT1 WILD-TYPE | 8 | 2 | 193 |
P value = 0.374 (Fisher's exact test), Q value = 1
Table S203. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 57 | 67 | 39 |
ACVR1B MUTATED | 3 | 2 | 2 | 4 |
ACVR1B WILD-TYPE | 39 | 55 | 65 | 35 |
P value = 0.316 (Fisher's exact test), Q value = 1
Table S204. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 48 | 61 | 56 |
ACVR1B MUTATED | 0 | 3 | 5 | 3 |
ACVR1B WILD-TYPE | 40 | 45 | 56 | 53 |
P value = 0.0986 (Fisher's exact test), Q value = 1
Table S205. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #3: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 69 | 85 | 62 | 4 |
ACVR1B MUTATED | 2 | 10 | 2 | 0 |
ACVR1B WILD-TYPE | 67 | 75 | 60 | 4 |
P value = 0.735 (Fisher's exact test), Q value = 1
Table S206. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #5: 'RPPA_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 40 | 67 | 24 | 26 |
ACVR1B MUTATED | 2 | 5 | 1 | 3 |
ACVR1B WILD-TYPE | 38 | 62 | 23 | 23 |
P value = 0.376 (Fisher's exact test), Q value = 1
Table S207. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #6: 'RPPA_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 20 | 109 | 19 | 9 |
ACVR1B MUTATED | 1 | 7 | 3 | 0 |
ACVR1B WILD-TYPE | 19 | 102 | 16 | 9 |
P value = 1 (Fisher's exact test), Q value = 1
Table S208. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 7 | 28 | 17 | 168 |
ACVR1B MUTATED | 0 | 2 | 1 | 11 |
ACVR1B WILD-TYPE | 7 | 26 | 16 | 157 |
P value = 1 (Fisher's exact test), Q value = 1
Table S209. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 213 | 2 |
ACVR1B MUTATED | 0 | 14 | 0 |
ACVR1B WILD-TYPE | 5 | 199 | 2 |
P value = 0.581 (Fisher's exact test), Q value = 1
Table S210. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 3 | 9 | 194 |
ACVR1B MUTATED | 0 | 1 | 13 |
ACVR1B WILD-TYPE | 3 | 8 | 181 |
P value = 1 (Fisher's exact test), Q value = 1
Table S211. Gene #24: 'ACVR1B MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 8 | 2 | 196 |
ACVR1B MUTATED | 0 | 0 | 14 |
ACVR1B WILD-TYPE | 8 | 2 | 182 |
-
Mutation data file = transformed.cor.cli.txt
-
Molecular subtypes file = COADREAD-TP.transferedmergedcluster.txt
-
Number of patients = 223
-
Number of significantly mutated genes = 24
-
Number of Molecular subtypes = 10
-
Exclude genes that fewer than K tumors have mutations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.