This pipeline computes the correlation between significant copy number variation (cnv focal) genes and molecular subtypes.
Testing the association between copy number variation 28 focal events and 8 molecular subtypes across 197 patients, 61 significant findings detected with P value < 0.05 and Q value < 0.25.
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amp_2p23.2 cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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amp_2q32.1 cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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amp_3q22.3 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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amp_7q22.1 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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amp_17q25.2 cnv correlated to 'CN_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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amp_19p13.2 cnv correlated to 'CN_CNMF'.
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del_1p36.31 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_3p22.1 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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del_4q34.3 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_5p14.2 cnv correlated to 'METHLYATION_CNMF'.
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del_5q15 cnv correlated to 'METHLYATION_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
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del_5q35.2 cnv correlated to 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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del_9p21.3 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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del_10p11.21 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_11q22.3 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_11q24.2 cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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del_14q11.2 cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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del_14q32.2 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_15q15.2 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_16q24.1 cnv correlated to 'METHLYATION_CNMF'.
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del_21q22.3 cnv correlated to 'CN_CNMF'.
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del_xp11.22 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
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del_xq28 cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Table 1. Get Full Table Overview of the association between significant copy number variation of 28 focal events and 8 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, 61 significant findings detected.
Clinical Features |
CN CNMF |
METHLYATION CNMF |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Chi-square test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
del 3p22 1 | 15 (8%) | 182 |
1.54e-05 (0.00289) |
1.44e-07 (2.96e-05) |
1.73e-05 (0.00324) |
0.000192 (0.0341) |
0.186 (1.00) |
0.00139 (0.23) |
0.0193 (1.00) |
7.47e-07 (0.000151) |
amp 3q22 3 | 68 (35%) | 129 |
2.54e-15 (5.61e-13) |
1.05e-05 (0.002) |
5.27e-07 (0.000107) |
0.000303 (0.0531) |
0.0532 (1.00) |
0.153 (1.00) |
0.163 (1.00) |
0.002 (0.324) |
amp 7q22 1 | 119 (60%) | 78 |
1.51e-15 (3.34e-13) |
5.14e-06 (0.001) |
5.55e-13 (1.2e-10) |
1.18e-12 (2.54e-10) |
0.161 (1.00) |
0.534 (1.00) |
0.0975 (1.00) |
0.00352 (0.553) |
del 9p21 3 | 27 (14%) | 170 |
3.56e-06 (0.000701) |
5.89e-11 (1.27e-08) |
4e-08 (8.37e-06) |
0.000148 (0.0266) |
0.039 (1.00) |
0.0218 (1.00) |
0.0923 (1.00) |
0.0037 (0.573) |
amp 17q25 2 | 143 (73%) | 54 |
1.02e-09 (2.17e-07) |
0.00381 (0.587) |
3.42e-06 (0.000678) |
1.25e-07 (2.59e-05) |
0.504 (1.00) |
1 (1.00) |
0.605 (1.00) |
0.617 (1.00) |
del 1p36 31 | 37 (19%) | 160 |
3.85e-13 (8.4e-11) |
8.32e-07 (0.000167) |
4.03e-07 (8.23e-05) |
0.053 (1.00) |
1 (1.00) |
0.945 (1.00) |
0.918 (1.00) |
0.1 (1.00) |
del 4q34 3 | 21 (11%) | 176 |
1.2e-07 (2.49e-05) |
5.95e-10 (1.27e-07) |
3.79e-08 (7.96e-06) |
0.00241 (0.386) |
0.625 (1.00) |
0.411 (1.00) |
0.734 (1.00) |
0.0763 (1.00) |
del 5q35 2 | 11 (6%) | 186 |
0.0862 (1.00) |
2.03e-08 (4.3e-06) |
0.000682 (0.115) |
0.00116 (0.193) |
0.337 (1.00) |
0.0731 (1.00) |
0.217 (1.00) |
0.00466 (0.712) |
del 10p11 21 | 12 (6%) | 185 |
0.000379 (0.0651) |
7.12e-06 (0.00137) |
0.000342 (0.0594) |
0.0509 (1.00) |
0.566 (1.00) |
0.0171 (1.00) |
0.235 (1.00) |
0.00328 (0.518) |
del 11q22 3 | 18 (9%) | 179 |
0.000257 (0.0453) |
9.21e-05 (0.0167) |
0.00128 (0.213) |
0.053 (1.00) |
0.594 (1.00) |
0.0886 (1.00) |
0.137 (1.00) |
0.0712 (1.00) |
del 14q32 2 | 39 (20%) | 158 |
1.78e-14 (3.91e-12) |
0.000432 (0.0734) |
0.000256 (0.0453) |
0.00159 (0.26) |
0.665 (1.00) |
0.55 (1.00) |
0.572 (1.00) |
0.224 (1.00) |
del 15q15 2 | 22 (11%) | 175 |
5.4e-06 (0.00105) |
1.94e-05 (0.00361) |
0.00041 (0.07) |
0.0248 (1.00) |
0.0794 (1.00) |
0.158 (1.00) |
0.0562 (1.00) |
0.0479 (1.00) |
del xp11 22 | 18 (9%) | 179 |
2.42e-06 (0.000481) |
3.02e-08 (6.37e-06) |
6.48e-06 (0.00125) |
0.00997 (1.00) |
0.17 (1.00) |
0.0549 (1.00) |
0.203 (1.00) |
0.0117 (1.00) |
amp 2p23 2 | 37 (19%) | 160 |
1.12e-27 (2.51e-25) |
5.61e-05 (0.0103) |
0.0312 (1.00) |
0.104 (1.00) |
0.0519 (1.00) |
0.757 (1.00) |
0.00731 (1.00) |
0.68 (1.00) |
amp 2q32 1 | 45 (23%) | 152 |
4.21e-24 (9.39e-22) |
0.000342 (0.0594) |
0.0428 (1.00) |
0.0295 (1.00) |
0.138 (1.00) |
0.831 (1.00) |
0.0286 (1.00) |
0.418 (1.00) |
del 5q15 | 11 (6%) | 186 |
0.35 (1.00) |
3.35e-05 (0.00617) |
0.00493 (0.749) |
0.000185 (0.0331) |
0.287 (1.00) |
0.0731 (1.00) |
0.398 (1.00) |
0.0441 (1.00) |
del 11q24 2 | 19 (10%) | 178 |
0.000848 (0.143) |
1.1e-05 (0.0021) |
0.00239 (0.384) |
0.134 (1.00) |
0.823 (1.00) |
0.177 (1.00) |
0.255 (1.00) |
0.0527 (1.00) |
del 14q11 2 | 39 (20%) | 158 |
2.99e-14 (6.55e-12) |
0.00152 (0.249) |
0.00359 (0.56) |
0.00545 (0.823) |
0.665 (1.00) |
0.55 (1.00) |
0.572 (1.00) |
0.381 (1.00) |
del xq28 | 17 (9%) | 180 |
1.38e-05 (0.0026) |
1.54e-06 (0.000308) |
0.00266 (0.423) |
0.265 (1.00) |
0.217 (1.00) |
0.417 (1.00) |
0.335 (1.00) |
0.065 (1.00) |
amp 19p13 2 | 21 (11%) | 176 |
3.09e-07 (6.33e-05) |
0.185 (1.00) |
0.0358 (1.00) |
0.0688 (1.00) |
0.668 (1.00) |
0.798 (1.00) |
0.533 (1.00) |
0.834 (1.00) |
del 5p14 2 | 10 (5%) | 187 |
0.506 (1.00) |
3.64e-06 (0.000713) |
0.144 (1.00) |
0.0599 (1.00) |
0.108 (1.00) |
0.337 (1.00) |
0.173 (1.00) |
0.327 (1.00) |
del 16q24 1 | 7 (4%) | 190 |
0.0899 (1.00) |
8e-05 (0.0146) |
0.0309 (1.00) |
0.0778 (1.00) |
0.703 (1.00) |
0.589 (1.00) |
1 (1.00) |
0.0944 (1.00) |
del 21q22 3 | 33 (17%) | 164 |
3.02e-05 (0.00559) |
0.166 (1.00) |
0.676 (1.00) |
1 (1.00) |
0.514 (1.00) |
0.6 (1.00) |
0.22 (1.00) |
0.808 (1.00) |
del 2q37 3 | 9 (5%) | 188 |
0.1 (1.00) |
0.0283 (1.00) |
0.151 (1.00) |
0.0124 (1.00) |
0.25 (1.00) |
1 (1.00) |
0.0643 (1.00) |
0.496 (1.00) |
del 6q21 | 17 (9%) | 180 |
0.00736 (1.00) |
0.00699 (1.00) |
0.012 (1.00) |
0.265 (1.00) |
1 (1.00) |
0.422 (1.00) |
0.503 (1.00) |
0.0983 (1.00) |
del 6q22 31 | 18 (9%) | 179 |
0.0113 (1.00) |
0.0126 (1.00) |
0.00582 (0.872) |
0.183 (1.00) |
0.846 (1.00) |
0.321 (1.00) |
0.376 (1.00) |
0.0712 (1.00) |
del 19p13 3 | 16 (8%) | 181 |
0.0192 (1.00) |
0.0331 (1.00) |
0.0321 (1.00) |
0.0361 (1.00) |
0.385 (1.00) |
0.182 (1.00) |
0.114 (1.00) |
0.0547 (1.00) |
del 19q13 42 | 15 (8%) | 182 |
0.0394 (1.00) |
0.0767 (1.00) |
0.0108 (1.00) |
0.173 (1.00) |
0.5 (1.00) |
0.831 (1.00) |
0.0193 (1.00) |
0.914 (1.00) |
P value = 1.12e-27 (Chi-square test), Q value = 2.5e-25
Table S1. Gene #1: 'amp_2p23.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 1(2P23.2) MUTATED | 2 | 2 | 6 | 0 | 27 |
AMP PEAK 1(2P23.2) WILD-TYPE | 69 | 38 | 31 | 21 | 1 |
Figure S1. Get High-res Image Gene #1: 'amp_2p23.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D1V1.png)
P value = 5.61e-05 (Chi-square test), Q value = 0.01
Table S2. Gene #1: 'amp_2p23.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
AMP PEAK 1(2P23.2) MUTATED | 3 | 8 | 4 | 18 | 1 |
AMP PEAK 1(2P23.2) WILD-TYPE | 35 | 16 | 29 | 30 | 37 |
Figure S2. Get High-res Image Gene #1: 'amp_2p23.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D1V2.png)
P value = 4.21e-24 (Chi-square test), Q value = 9.4e-22
Table S3. Gene #2: 'amp_2q32.1' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 2(2Q32.1) MUTATED | 5 | 2 | 9 | 1 | 28 |
AMP PEAK 2(2Q32.1) WILD-TYPE | 66 | 38 | 28 | 20 | 0 |
Figure S3. Get High-res Image Gene #2: 'amp_2q32.1' versus Molecular Subtype #1: 'CN_CNMF'
![](D2V1.png)
P value = 0.000342 (Chi-square test), Q value = 0.059
Table S4. Gene #2: 'amp_2q32.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
AMP PEAK 2(2Q32.1) MUTATED | 6 | 8 | 7 | 20 | 1 |
AMP PEAK 2(2Q32.1) WILD-TYPE | 32 | 16 | 26 | 28 | 37 |
Figure S4. Get High-res Image Gene #2: 'amp_2q32.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D2V2.png)
P value = 2.54e-15 (Chi-square test), Q value = 5.6e-13
Table S5. Gene #3: 'amp_3q22.3' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 3(3Q22.3) MUTATED | 12 | 9 | 6 | 21 | 20 |
AMP PEAK 3(3Q22.3) WILD-TYPE | 59 | 31 | 31 | 0 | 8 |
Figure S5. Get High-res Image Gene #3: 'amp_3q22.3' versus Molecular Subtype #1: 'CN_CNMF'
![](D3V1.png)
P value = 1.05e-05 (Chi-square test), Q value = 0.002
Table S6. Gene #3: 'amp_3q22.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
AMP PEAK 3(3Q22.3) MUTATED | 12 | 5 | 6 | 31 | 8 |
AMP PEAK 3(3Q22.3) WILD-TYPE | 26 | 19 | 27 | 17 | 30 |
Figure S6. Get High-res Image Gene #3: 'amp_3q22.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D3V2.png)
P value = 5.27e-07 (Fisher's exact test), Q value = 0.00011
Table S7. Gene #3: 'amp_3q22.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
AMP PEAK 3(3Q22.3) MUTATED | 22 | 7 | 23 | 16 |
AMP PEAK 3(3Q22.3) WILD-TYPE | 17 | 60 | 36 | 16 |
Figure S7. Get High-res Image Gene #3: 'amp_3q22.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D3V3.png)
P value = 0.000303 (Fisher's exact test), Q value = 0.053
Table S8. Gene #3: 'amp_3q22.3' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
AMP PEAK 3(3Q22.3) MUTATED | 37 | 19 | 12 |
AMP PEAK 3(3Q22.3) WILD-TYPE | 33 | 52 | 44 |
Figure S8. Get High-res Image Gene #3: 'amp_3q22.3' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D3V4.png)
P value = 1.51e-15 (Chi-square test), Q value = 3.3e-13
Table S9. Gene #4: 'amp_7q22.1' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 4(7Q22.1) MUTATED | 23 | 40 | 13 | 20 | 23 |
AMP PEAK 4(7Q22.1) WILD-TYPE | 48 | 0 | 24 | 1 | 5 |
Figure S9. Get High-res Image Gene #4: 'amp_7q22.1' versus Molecular Subtype #1: 'CN_CNMF'
![](D4V1.png)
P value = 5.14e-06 (Chi-square test), Q value = 0.001
Table S10. Gene #4: 'amp_7q22.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
AMP PEAK 4(7Q22.1) MUTATED | 18 | 9 | 12 | 39 | 30 |
AMP PEAK 4(7Q22.1) WILD-TYPE | 20 | 15 | 21 | 9 | 8 |
Figure S10. Get High-res Image Gene #4: 'amp_7q22.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D4V2.png)
P value = 5.55e-13 (Fisher's exact test), Q value = 1.2e-10
Table S11. Gene #4: 'amp_7q22.1' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
AMP PEAK 4(7Q22.1) MUTATED | 21 | 19 | 53 | 26 |
AMP PEAK 4(7Q22.1) WILD-TYPE | 18 | 48 | 6 | 6 |
Figure S11. Get High-res Image Gene #4: 'amp_7q22.1' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D4V3.png)
P value = 1.18e-12 (Fisher's exact test), Q value = 2.5e-10
Table S12. Gene #4: 'amp_7q22.1' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
AMP PEAK 4(7Q22.1) MUTATED | 65 | 28 | 26 |
AMP PEAK 4(7Q22.1) WILD-TYPE | 5 | 43 | 30 |
Figure S12. Get High-res Image Gene #4: 'amp_7q22.1' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D4V4.png)
P value = 1.02e-09 (Chi-square test), Q value = 2.2e-07
Table S13. Gene #5: 'amp_17q25.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 5(17Q25.2) MUTATED | 38 | 40 | 19 | 19 | 27 |
AMP PEAK 5(17Q25.2) WILD-TYPE | 33 | 0 | 18 | 2 | 1 |
Figure S13. Get High-res Image Gene #5: 'amp_17q25.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D5V1.png)
P value = 3.42e-06 (Fisher's exact test), Q value = 0.00068
Table S14. Gene #5: 'amp_17q25.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
AMP PEAK 5(17Q25.2) MUTATED | 31 | 34 | 54 | 24 |
AMP PEAK 5(17Q25.2) WILD-TYPE | 8 | 33 | 5 | 8 |
Figure S14. Get High-res Image Gene #5: 'amp_17q25.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D5V3.png)
P value = 1.25e-07 (Fisher's exact test), Q value = 2.6e-05
Table S15. Gene #5: 'amp_17q25.2' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
AMP PEAK 5(17Q25.2) MUTATED | 66 | 47 | 30 |
AMP PEAK 5(17Q25.2) WILD-TYPE | 4 | 24 | 26 |
Figure S15. Get High-res Image Gene #5: 'amp_17q25.2' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D5V4.png)
P value = 3.09e-07 (Chi-square test), Q value = 6.3e-05
Table S16. Gene #6: 'amp_19p13.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
AMP PEAK 6(19P13.2) MUTATED | 0 | 14 | 4 | 0 | 3 |
AMP PEAK 6(19P13.2) WILD-TYPE | 71 | 26 | 33 | 21 | 25 |
Figure S16. Get High-res Image Gene #6: 'amp_19p13.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D6V1.png)
P value = 3.85e-13 (Chi-square test), Q value = 8.4e-11
Table S17. Gene #7: 'del_1p36.31' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 1(1P36.31) MUTATED | 7 | 0 | 23 | 0 | 7 |
DEL PEAK 1(1P36.31) WILD-TYPE | 64 | 40 | 14 | 21 | 21 |
Figure S17. Get High-res Image Gene #7: 'del_1p36.31' versus Molecular Subtype #1: 'CN_CNMF'
![](D7V1.png)
P value = 8.32e-07 (Chi-square test), Q value = 0.00017
Table S18. Gene #7: 'del_1p36.31' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 1(1P36.31) MUTATED | 6 | 14 | 6 | 8 | 0 |
DEL PEAK 1(1P36.31) WILD-TYPE | 32 | 10 | 27 | 40 | 38 |
Figure S18. Get High-res Image Gene #7: 'del_1p36.31' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D7V2.png)
P value = 4.03e-07 (Fisher's exact test), Q value = 8.2e-05
Table S19. Gene #7: 'del_1p36.31' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 1(1P36.31) MUTATED | 5 | 27 | 5 | 0 |
DEL PEAK 1(1P36.31) WILD-TYPE | 34 | 40 | 54 | 32 |
Figure S19. Get High-res Image Gene #7: 'del_1p36.31' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D7V3.png)
P value = 1.54e-05 (Chi-square test), Q value = 0.0029
Table S20. Gene #9: 'del_3p22.1' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 3(3P22.1) MUTATED | 2 | 0 | 10 | 0 | 3 |
DEL PEAK 3(3P22.1) WILD-TYPE | 69 | 40 | 27 | 21 | 25 |
Figure S20. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #1: 'CN_CNMF'
![](D9V1.png)
P value = 1.44e-07 (Chi-square test), Q value = 3e-05
Table S21. Gene #9: 'del_3p22.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 3(3P22.1) MUTATED | 0 | 8 | 6 | 0 | 0 |
DEL PEAK 3(3P22.1) WILD-TYPE | 38 | 16 | 27 | 48 | 38 |
Figure S21. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D9V2.png)
P value = 1.73e-05 (Fisher's exact test), Q value = 0.0032
Table S22. Gene #9: 'del_3p22.1' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 3(3P22.1) MUTATED | 1 | 14 | 0 | 0 |
DEL PEAK 3(3P22.1) WILD-TYPE | 38 | 53 | 59 | 32 |
Figure S22. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D9V3.png)
P value = 0.000192 (Fisher's exact test), Q value = 0.034
Table S23. Gene #9: 'del_3p22.1' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
DEL PEAK 3(3P22.1) MUTATED | 0 | 12 | 3 |
DEL PEAK 3(3P22.1) WILD-TYPE | 70 | 59 | 53 |
Figure S23. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D9V4.png)
P value = 0.00139 (Fisher's exact test), Q value = 0.23
Table S24. Gene #9: 'del_3p22.1' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 29 | 78 | 90 |
DEL PEAK 3(3P22.1) MUTATED | 7 | 6 | 2 |
DEL PEAK 3(3P22.1) WILD-TYPE | 22 | 72 | 88 |
Figure S24. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'
![](D9V6.png)
P value = 7.47e-07 (Fisher's exact test), Q value = 0.00015
Table S25. Gene #9: 'del_3p22.1' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 75 | 99 | 23 |
DEL PEAK 3(3P22.1) MUTATED | 5 | 1 | 9 |
DEL PEAK 3(3P22.1) WILD-TYPE | 70 | 98 | 14 |
Figure S25. Get High-res Image Gene #9: 'del_3p22.1' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'
![](D9V8.png)
P value = 1.2e-07 (Chi-square test), Q value = 2.5e-05
Table S26. Gene #10: 'del_4q34.3' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 4(4Q34.3) MUTATED | 4 | 0 | 14 | 0 | 3 |
DEL PEAK 4(4Q34.3) WILD-TYPE | 67 | 40 | 23 | 21 | 25 |
Figure S26. Get High-res Image Gene #10: 'del_4q34.3' versus Molecular Subtype #1: 'CN_CNMF'
![](D10V1.png)
P value = 5.95e-10 (Chi-square test), Q value = 1.3e-07
Table S27. Gene #10: 'del_4q34.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 4(4Q34.3) MUTATED | 1 | 12 | 4 | 2 | 0 |
DEL PEAK 4(4Q34.3) WILD-TYPE | 37 | 12 | 29 | 46 | 38 |
Figure S27. Get High-res Image Gene #10: 'del_4q34.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D10V2.png)
P value = 3.79e-08 (Fisher's exact test), Q value = 8e-06
Table S28. Gene #10: 'del_4q34.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 4(4Q34.3) MUTATED | 1 | 20 | 0 | 0 |
DEL PEAK 4(4Q34.3) WILD-TYPE | 38 | 47 | 59 | 32 |
Figure S28. Get High-res Image Gene #10: 'del_4q34.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D10V3.png)
P value = 3.64e-06 (Chi-square test), Q value = 0.00071
Table S29. Gene #11: 'del_5p14.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 5(5P14.2) MUTATED | 1 | 7 | 0 | 2 | 0 |
DEL PEAK 5(5P14.2) WILD-TYPE | 37 | 17 | 33 | 46 | 38 |
Figure S29. Get High-res Image Gene #11: 'del_5p14.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D11V2.png)
P value = 3.35e-05 (Chi-square test), Q value = 0.0062
Table S30. Gene #12: 'del_5q15' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 6(5Q15) MUTATED | 1 | 7 | 1 | 1 | 1 |
DEL PEAK 6(5Q15) WILD-TYPE | 37 | 17 | 32 | 47 | 37 |
Figure S30. Get High-res Image Gene #12: 'del_5q15' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D12V2.png)
P value = 0.000185 (Fisher's exact test), Q value = 0.033
Table S31. Gene #12: 'del_5q15' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
DEL PEAK 6(5Q15) MUTATED | 0 | 2 | 9 |
DEL PEAK 6(5Q15) WILD-TYPE | 70 | 69 | 47 |
Figure S31. Get High-res Image Gene #12: 'del_5q15' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D12V4.png)
P value = 2.03e-08 (Chi-square test), Q value = 4.3e-06
Table S32. Gene #13: 'del_5q35.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 7(5Q35.2) MUTATED | 1 | 8 | 1 | 0 | 0 |
DEL PEAK 7(5Q35.2) WILD-TYPE | 37 | 16 | 32 | 48 | 38 |
Figure S32. Get High-res Image Gene #13: 'del_5q35.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D13V2.png)
P value = 0.000682 (Fisher's exact test), Q value = 0.12
Table S33. Gene #13: 'del_5q35.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 7(5Q35.2) MUTATED | 1 | 10 | 0 | 0 |
DEL PEAK 7(5Q35.2) WILD-TYPE | 38 | 57 | 59 | 32 |
Figure S33. Get High-res Image Gene #13: 'del_5q35.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D13V3.png)
P value = 0.00116 (Fisher's exact test), Q value = 0.19
Table S34. Gene #13: 'del_5q35.2' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
DEL PEAK 7(5Q35.2) MUTATED | 0 | 3 | 8 |
DEL PEAK 7(5Q35.2) WILD-TYPE | 70 | 68 | 48 |
Figure S34. Get High-res Image Gene #13: 'del_5q35.2' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D13V4.png)
P value = 3.56e-06 (Chi-square test), Q value = 7e-04
Table S35. Gene #16: 'del_9p21.3' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 10(9P21.3) MUTATED | 8 | 1 | 15 | 0 | 3 |
DEL PEAK 10(9P21.3) WILD-TYPE | 63 | 39 | 22 | 21 | 25 |
Figure S35. Get High-res Image Gene #16: 'del_9p21.3' versus Molecular Subtype #1: 'CN_CNMF'
![](D16V1.png)
P value = 5.89e-11 (Chi-square test), Q value = 1.3e-08
Table S36. Gene #16: 'del_9p21.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 10(9P21.3) MUTATED | 4 | 14 | 5 | 1 | 0 |
DEL PEAK 10(9P21.3) WILD-TYPE | 34 | 10 | 28 | 47 | 38 |
Figure S36. Get High-res Image Gene #16: 'del_9p21.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D16V2.png)
P value = 4e-08 (Fisher's exact test), Q value = 8.4e-06
Table S37. Gene #16: 'del_9p21.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 10(9P21.3) MUTATED | 3 | 23 | 0 | 1 |
DEL PEAK 10(9P21.3) WILD-TYPE | 36 | 44 | 59 | 31 |
Figure S37. Get High-res Image Gene #16: 'del_9p21.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D16V3.png)
P value = 0.000148 (Fisher's exact test), Q value = 0.027
Table S38. Gene #16: 'del_9p21.3' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 70 | 71 | 56 |
DEL PEAK 10(9P21.3) MUTATED | 1 | 13 | 13 |
DEL PEAK 10(9P21.3) WILD-TYPE | 69 | 58 | 43 |
Figure S38. Get High-res Image Gene #16: 'del_9p21.3' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'
![](D16V4.png)
P value = 0.000379 (Chi-square test), Q value = 0.065
Table S39. Gene #17: 'del_10p11.21' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 11(10P11.21) MUTATED | 1 | 0 | 7 | 0 | 4 |
DEL PEAK 11(10P11.21) WILD-TYPE | 70 | 40 | 30 | 21 | 24 |
Figure S39. Get High-res Image Gene #17: 'del_10p11.21' versus Molecular Subtype #1: 'CN_CNMF'
![](D17V1.png)
P value = 7.12e-06 (Chi-square test), Q value = 0.0014
Table S40. Gene #17: 'del_10p11.21' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 11(10P11.21) MUTATED | 0 | 7 | 3 | 1 | 0 |
DEL PEAK 11(10P11.21) WILD-TYPE | 38 | 17 | 30 | 47 | 38 |
Figure S40. Get High-res Image Gene #17: 'del_10p11.21' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D17V2.png)
P value = 0.000342 (Fisher's exact test), Q value = 0.059
Table S41. Gene #17: 'del_10p11.21' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 11(10P11.21) MUTATED | 0 | 11 | 1 | 0 |
DEL PEAK 11(10P11.21) WILD-TYPE | 39 | 56 | 58 | 32 |
Figure S41. Get High-res Image Gene #17: 'del_10p11.21' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D17V3.png)
P value = 0.000257 (Chi-square test), Q value = 0.045
Table S42. Gene #18: 'del_11q22.3' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 12(11Q22.3) MUTATED | 3 | 1 | 10 | 0 | 4 |
DEL PEAK 12(11Q22.3) WILD-TYPE | 68 | 39 | 27 | 21 | 24 |
Figure S42. Get High-res Image Gene #18: 'del_11q22.3' versus Molecular Subtype #1: 'CN_CNMF'
![](D18V1.png)
P value = 9.21e-05 (Chi-square test), Q value = 0.017
Table S43. Gene #18: 'del_11q22.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 12(11Q22.3) MUTATED | 2 | 8 | 5 | 2 | 0 |
DEL PEAK 12(11Q22.3) WILD-TYPE | 36 | 16 | 28 | 46 | 38 |
Figure S43. Get High-res Image Gene #18: 'del_11q22.3' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D18V2.png)
P value = 0.00128 (Fisher's exact test), Q value = 0.21
Table S44. Gene #18: 'del_11q22.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 12(11Q22.3) MUTATED | 2 | 14 | 1 | 1 |
DEL PEAK 12(11Q22.3) WILD-TYPE | 37 | 53 | 58 | 31 |
Figure S44. Get High-res Image Gene #18: 'del_11q22.3' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D18V3.png)
P value = 0.000848 (Chi-square test), Q value = 0.14
Table S45. Gene #19: 'del_11q24.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 13(11Q24.2) MUTATED | 3 | 1 | 10 | 1 | 4 |
DEL PEAK 13(11Q24.2) WILD-TYPE | 68 | 39 | 27 | 20 | 24 |
Figure S45. Get High-res Image Gene #19: 'del_11q24.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D19V1.png)
P value = 1.1e-05 (Chi-square test), Q value = 0.0021
Table S46. Gene #19: 'del_11q24.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 13(11Q24.2) MUTATED | 2 | 9 | 5 | 2 | 0 |
DEL PEAK 13(11Q24.2) WILD-TYPE | 36 | 15 | 28 | 46 | 38 |
Figure S46. Get High-res Image Gene #19: 'del_11q24.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D19V2.png)
P value = 2.99e-14 (Chi-square test), Q value = 6.5e-12
Table S47. Gene #20: 'del_14q11.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 14(14Q11.2) MUTATED | 5 | 1 | 25 | 2 | 6 |
DEL PEAK 14(14Q11.2) WILD-TYPE | 66 | 39 | 12 | 19 | 22 |
Figure S47. Get High-res Image Gene #20: 'del_14q11.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D20V1.png)
P value = 0.00152 (Chi-square test), Q value = 0.25
Table S48. Gene #20: 'del_14q11.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 14(14Q11.2) MUTATED | 11 | 10 | 3 | 8 | 2 |
DEL PEAK 14(14Q11.2) WILD-TYPE | 27 | 14 | 30 | 40 | 36 |
Figure S48. Get High-res Image Gene #20: 'del_14q11.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D20V2.png)
P value = 1.78e-14 (Chi-square test), Q value = 3.9e-12
Table S49. Gene #21: 'del_14q32.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 15(14Q32.2) MUTATED | 7 | 0 | 25 | 1 | 6 |
DEL PEAK 15(14Q32.2) WILD-TYPE | 64 | 40 | 12 | 20 | 22 |
Figure S49. Get High-res Image Gene #21: 'del_14q32.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D21V1.png)
P value = 0.000432 (Chi-square test), Q value = 0.073
Table S50. Gene #21: 'del_14q32.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 15(14Q32.2) MUTATED | 11 | 11 | 3 | 8 | 2 |
DEL PEAK 15(14Q32.2) WILD-TYPE | 27 | 13 | 30 | 40 | 36 |
Figure S50. Get High-res Image Gene #21: 'del_14q32.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D21V2.png)
P value = 0.000256 (Fisher's exact test), Q value = 0.045
Table S51. Gene #21: 'del_14q32.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 15(14Q32.2) MUTATED | 8 | 24 | 4 | 3 |
DEL PEAK 15(14Q32.2) WILD-TYPE | 31 | 43 | 55 | 29 |
Figure S51. Get High-res Image Gene #21: 'del_14q32.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D21V3.png)
P value = 5.4e-06 (Chi-square test), Q value = 0.001
Table S52. Gene #22: 'del_15q15.2' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 16(15Q15.2) MUTATED | 4 | 0 | 13 | 1 | 4 |
DEL PEAK 16(15Q15.2) WILD-TYPE | 67 | 40 | 24 | 20 | 24 |
Figure S52. Get High-res Image Gene #22: 'del_15q15.2' versus Molecular Subtype #1: 'CN_CNMF'
![](D22V1.png)
P value = 1.94e-05 (Chi-square test), Q value = 0.0036
Table S53. Gene #22: 'del_15q15.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 16(15Q15.2) MUTATED | 7 | 9 | 2 | 2 | 0 |
DEL PEAK 16(15Q15.2) WILD-TYPE | 31 | 15 | 31 | 46 | 38 |
Figure S53. Get High-res Image Gene #22: 'del_15q15.2' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D22V2.png)
P value = 0.00041 (Fisher's exact test), Q value = 0.07
Table S54. Gene #22: 'del_15q15.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 16(15Q15.2) MUTATED | 4 | 16 | 2 | 0 |
DEL PEAK 16(15Q15.2) WILD-TYPE | 35 | 51 | 57 | 32 |
Figure S54. Get High-res Image Gene #22: 'del_15q15.2' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D22V3.png)
P value = 8e-05 (Chi-square test), Q value = 0.015
Table S55. Gene #23: 'del_16q24.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 17(16Q24.1) MUTATED | 0 | 5 | 2 | 0 | 0 |
DEL PEAK 17(16Q24.1) WILD-TYPE | 38 | 19 | 31 | 48 | 38 |
Figure S55. Get High-res Image Gene #23: 'del_16q24.1' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D23V2.png)
P value = 3.02e-05 (Chi-square test), Q value = 0.0056
Table S56. Gene #26: 'del_21q22.3' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 20(21Q22.3) MUTATED | 5 | 4 | 9 | 2 | 13 |
DEL PEAK 20(21Q22.3) WILD-TYPE | 66 | 36 | 28 | 19 | 15 |
Figure S56. Get High-res Image Gene #26: 'del_21q22.3' versus Molecular Subtype #1: 'CN_CNMF'
![](D26V1.png)
P value = 2.42e-06 (Chi-square test), Q value = 0.00048
Table S57. Gene #27: 'del_xp11.22' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 21(XP11.22) MUTATED | 4 | 0 | 12 | 0 | 2 |
DEL PEAK 21(XP11.22) WILD-TYPE | 67 | 40 | 25 | 21 | 26 |
Figure S57. Get High-res Image Gene #27: 'del_xp11.22' versus Molecular Subtype #1: 'CN_CNMF'
![](D27V1.png)
P value = 3.02e-08 (Chi-square test), Q value = 6.4e-06
Table S58. Gene #27: 'del_xp11.22' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 21(XP11.22) MUTATED | 1 | 10 | 4 | 1 | 0 |
DEL PEAK 21(XP11.22) WILD-TYPE | 37 | 14 | 29 | 47 | 38 |
Figure S58. Get High-res Image Gene #27: 'del_xp11.22' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D27V2.png)
P value = 6.48e-06 (Fisher's exact test), Q value = 0.0012
Table S59. Gene #27: 'del_xp11.22' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 67 | 59 | 32 |
DEL PEAK 21(XP11.22) MUTATED | 2 | 16 | 0 | 0 |
DEL PEAK 21(XP11.22) WILD-TYPE | 37 | 51 | 59 | 32 |
Figure S59. Get High-res Image Gene #27: 'del_xp11.22' versus Molecular Subtype #3: 'MRNASEQ_CNMF'
![](D27V3.png)
P value = 1.38e-05 (Chi-square test), Q value = 0.0026
Table S60. Gene #28: 'del_xq28' versus Molecular Subtype #1: 'CN_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 71 | 40 | 37 | 21 | 28 |
DEL PEAK 22(XQ28) MUTATED | 5 | 0 | 11 | 0 | 1 |
DEL PEAK 22(XQ28) WILD-TYPE | 66 | 40 | 26 | 21 | 27 |
Figure S60. Get High-res Image Gene #28: 'del_xq28' versus Molecular Subtype #1: 'CN_CNMF'
![](D28V1.png)
P value = 1.54e-06 (Chi-square test), Q value = 0.00031
Table S61. Gene #28: 'del_xq28' versus Molecular Subtype #2: 'METHLYATION_CNMF'
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 38 | 24 | 33 | 48 | 38 |
DEL PEAK 22(XQ28) MUTATED | 1 | 9 | 2 | 3 | 0 |
DEL PEAK 22(XQ28) WILD-TYPE | 37 | 15 | 31 | 45 | 38 |
Figure S61. Get High-res Image Gene #28: 'del_xq28' versus Molecular Subtype #2: 'METHLYATION_CNMF'
![](D28V2.png)
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Copy number data file = transformed.cor.cli.txt
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Molecular subtype file = KIRP-TP.transferedmergedcluster.txt
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Number of patients = 197
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Number of significantly focal cnvs = 28
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Number of molecular subtypes = 8
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Exclude genes that fewer than K tumors have alterations, K = 3
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.