Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	160.0	8321.0	52.0	-0.653	0.352	1000.0	-1000.0	-0.094	-1000.0
Angiopoietin receptor Tie2-mediated signaling	159.0	14023.0	88.0	-0.77	0.06	1000.0	-1000.0	-0.144	-1000.0
Aurora B signaling	137.0	9214.0	67.0	-0.621	0.005	1000.0	-1000.0	-0.078	-1000.0
FOXM1 transcription factor network	122.0	6266.0	51.0	-0.706	0.002	1000.0	-1000.0	-0.194	-1000.0
Endothelins	75.0	7219.0	96.0	-0.448	0.038	1000.0	-1000.0	-0.108	-1000.0
Glypican 2 network	61.0	245.0	4.0	-0.085	-0.07	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	60.0	480.0	8.0	-0.278	0.085	1000.0	-1000.0	-0.033	-1000.0
amb2 Integrin signaling	58.0	4837.0	82.0	-0.683	0.0	1000.0	-1000.0	-0.104	-1000.0
Thromboxane A2 receptor signaling	52.0	5524.0	105.0	-0.177	0.039	1000.0	-1000.0	-0.082	-1000.0
Visual signal transduction: Cones	51.0	1965.0	38.0	-0.281	0.009	1000.0	-1000.0	-0.072	-1000.0
Aurora C signaling	50.0	355.0	7.0	-0.411	-0.0	1000.0	-1000.0	-0.051	-1000.0
Fc-epsilon receptor I signaling in mast cells	50.0	4904.0	97.0	-0.254	0.033	1000.0	-1000.0	-0.109	-1000.0
IL4-mediated signaling events	49.0	4470.0	91.0	-0.805	0.442	1000.0	-1000.0	-0.19	-1000.0
Glucocorticoid receptor regulatory network	49.0	5604.0	114.0	-0.559	0.367	1000.0	-1000.0	-0.09	-1000.0
Signaling events regulated by Ret tyrosine kinase	49.0	4025.0	82.0	-0.203	0.0	1000.0	-1000.0	-0.106	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	46.0	2410.0	52.0	-0.382	0.057	1000.0	-1000.0	-0.071	-1000.0
PLK1 signaling events	44.0	3781.0	85.0	-0.365	0.071	1000.0	-1000.0	-0.065	-1000.0
Arf6 signaling events	40.0	2515.0	62.0	-0.301	0.015	1000.0	-1000.0	-0.076	-1000.0
BMP receptor signaling	40.0	3246.0	81.0	-0.387	0.033	1000.0	-1000.0	-0.104	-1000.0
Canonical Wnt signaling pathway	38.0	1953.0	51.0	-0.469	0.165	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	36.0	2828.0	78.0	-0.125	0.035	1000.0	-1000.0	-0.091	-1000.0
Signaling mediated by p38-alpha and p38-beta	35.0	1571.0	44.0	-0.129	0.0	1000.0	-1000.0	-0.065	-1000.0
Presenilin action in Notch and Wnt signaling	34.0	2094.0	61.0	-0.47	0.013	1000.0	-1000.0	-0.093	-1000.0
TCGA08_p53	33.0	234.0	7.0	-0.193	0.097	1000.0	-1000.0	-0.032	-1000.0
Integrins in angiogenesis	33.0	2795.0	84.0	-0.465	0.002	1000.0	-1000.0	-0.119	-1000.0
Nongenotropic Androgen signaling	33.0	1718.0	52.0	-0.154	0.046	1000.0	-1000.0	-0.072	-1000.0
Nectin adhesion pathway	32.0	2072.0	63.0	-0.277	0.0	1000.0	-1000.0	-0.097	-1000.0
Glypican 1 network	31.0	1523.0	48.0	-0.218	0.03	1000.0	-1000.0	-0.059	-1000.0
FOXA2 and FOXA3 transcription factor networks	29.0	1365.0	46.0	-0.782	0.073	1000.0	-1000.0	-0.124	-1000.0
HIF-1-alpha transcription factor network	28.0	2192.0	76.0	-0.439	0.016	1000.0	-1000.0	-0.217	-1000.0
Coregulation of Androgen receptor activity	27.0	2067.0	76.0	-0.396	0.029	1000.0	-1000.0	-0.067	-1000.0
LPA4-mediated signaling events	26.0	314.0	12.0	-0.143	0.017	1000.0	-1000.0	-0.035	-1000.0
Syndecan-3-mediated signaling events	26.0	925.0	35.0	-0.341	0.0	1000.0	-1000.0	-0.079	-1000.0
IL23-mediated signaling events	25.0	1549.0	60.0	-0.243	0.018	1000.0	-1000.0	-0.199	-1000.0
IL6-mediated signaling events	24.0	1826.0	75.0	-0.474	0.05	1000.0	-1000.0	-0.104	-1000.0
ErbB4 signaling events	23.0	1605.0	69.0	-0.386	0.198	1000.0	-1000.0	-0.094	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	693.0	31.0	-0.212	0.012	1000.0	-1000.0	-0.146	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1560.0	68.0	-0.228	0.015	1000.0	-1000.0	-0.17	-1000.0
Visual signal transduction: Rods	22.0	1175.0	52.0	-0.176	0.0	1000.0	-1000.0	-0.095	-1000.0
Regulation of Androgen receptor activity	22.0	1564.0	70.0	-0.415	0.018	1000.0	-1000.0	-0.08	-1000.0
Syndecan-1-mediated signaling events	21.0	746.0	34.0	-0.354	0.0	1000.0	-1000.0	-0.076	-1000.0
Aurora A signaling	21.0	1293.0	60.0	-0.486	0.029	1000.0	-1000.0	-0.069	-1000.0
Reelin signaling pathway	21.0	1214.0	56.0	-0.13	0.003	1000.0	-1000.0	-0.12	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	21.0	2740.0	125.0	-0.207	0.0	1000.0	-1000.0	-0.138	-1000.0
Wnt signaling	21.0	150.0	7.0	-0.095	0.0	1000.0	-1000.0	-0.056	-1000.0
IL12-mediated signaling events	20.0	1772.0	87.0	-0.154	0.017	1000.0	-1000.0	-0.151	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	661.0	33.0	-0.269	0.0	1000.0	-1000.0	-0.076	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	20.0	2477.0	120.0	-0.27	0.127	1000.0	-1000.0	-0.102	-1000.0
Osteopontin-mediated events	18.0	717.0	38.0	-0.296	0.0	1000.0	-1000.0	-0.127	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1571.0	86.0	-0.177	0.032	1000.0	-1000.0	-0.095	-1000.0
p75(NTR)-mediated signaling	16.0	2085.0	125.0	-0.344	0.0	1000.0	-1000.0	-0.127	-1000.0
TCR signaling in naïve CD8+ T cells	16.0	1534.0	93.0	-0.063	0.036	1000.0	-1000.0	-0.098	-1000.0
PDGFR-alpha signaling pathway	15.0	665.0	44.0	-0.207	0.014	1000.0	-1000.0	-0.07	-1000.0
HIF-2-alpha transcription factor network	15.0	659.0	43.0	-0.373	0.203	1000.0	-1000.0	-0.12	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	14.0	795.0	54.0	-0.147	0.02	1000.0	-1000.0	-0.118	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1210.0	85.0	-0.154	0.01	1000.0	-1000.0	-0.088	-1000.0
Effects of Botulinum toxin	14.0	374.0	26.0	-0.074	0.005	1000.0	-1000.0	-0.068	-1000.0
Regulation of nuclear SMAD2/3 signaling	13.0	1834.0	136.0	-0.33	0.093	1000.0	-1000.0	-0.097	-1000.0
Ephrin A  reverse signaling	13.0	91.0	7.0	-0.023	0.003	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	11.0	866.0	74.0	-0.069	0.035	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	11.0	301.0	26.0	-0.101	0.0	1000.0	-1000.0	-0.098	-1000.0
FAS signaling pathway (CD95)	11.0	539.0	47.0	-0.197	0.009	1000.0	-1000.0	-0.062	-1000.0
Syndecan-2-mediated signaling events	10.0	705.0	69.0	-0.167	0.033	1000.0	-1000.0	-0.069	-1000.0
EGFR-dependent Endothelin signaling events	10.0	217.0	21.0	-0.063	0.0	1000.0	-1000.0	-0.094	-1000.0
S1P4 pathway	10.0	262.0	25.0	-0.066	0.002	1000.0	-1000.0	-0.064	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	179.0	17.0	-0.054	0.008	1000.0	-1000.0	-0.076	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	163.0	17.0	-0.039	0.023	1000.0	-1000.0	-0.083	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	699.0	74.0	-0.17	0.068	1000.0	-1000.0	-0.112	-1000.0
BCR signaling pathway	9.0	977.0	99.0	-0.108	0.039	1000.0	-1000.0	-0.11	-1000.0
Syndecan-4-mediated signaling events	9.0	605.0	67.0	-0.167	0.009	1000.0	-1000.0	-0.098	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	305.0	34.0	-0.028	0.0	1000.0	-1000.0	-0.075	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	229.0	28.0	-0.177	0.02	1000.0	-1000.0	-0.074	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	576.0	65.0	-0.6	0.043	1000.0	-1000.0	-0.086	-1000.0
S1P1 pathway	8.0	320.0	36.0	-0.061	0.01	1000.0	-1000.0	-0.078	-1000.0
IL2 signaling events mediated by STAT5	8.0	177.0	22.0	-0.147	0.059	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by HDAC Class III	7.0	293.0	40.0	-0.15	0.051	1000.0	-1000.0	-0.054	-1000.0
TRAIL signaling pathway	7.0	353.0	48.0	-0.097	0.046	1000.0	-1000.0	-0.078	-1000.0
IL27-mediated signaling events	7.0	387.0	51.0	-0.123	0.011	1000.0	-1000.0	-0.085	-1000.0
Cellular roles of Anthrax toxin	6.0	255.0	39.0	-0.09	0.017	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PTP1B	6.0	514.0	76.0	-0.101	0.033	1000.0	-1000.0	-0.099	-1000.0
Retinoic acid receptors-mediated signaling	6.0	369.0	58.0	-0.22	0.034	1000.0	-1000.0	-0.079	-1000.0
S1P3 pathway	6.0	260.0	42.0	-0.177	0.042	1000.0	-1000.0	-0.063	-1000.0
BARD1 signaling events	5.0	288.0	57.0	-0.126	0.022	1000.0	-1000.0	-0.08	-1000.0
IL1-mediated signaling events	5.0	347.0	62.0	-0.058	0.042	1000.0	-1000.0	-0.114	-1000.0
Ephrin B reverse signaling	5.0	275.0	48.0	-0.07	0.04	1000.0	-1000.0	-0.078	-1000.0
IL2 signaling events mediated by PI3K	5.0	299.0	58.0	-0.225	0.073	1000.0	-1000.0	-0.102	-1000.0
Regulation of p38-alpha and p38-beta	5.0	315.0	54.0	-0.095	0.037	1000.0	-1000.0	-0.092	-1000.0
LPA receptor mediated events	5.0	597.0	102.0	-0.1	0.034	1000.0	-1000.0	-0.105	-1000.0
IGF1 pathway	5.0	291.0	57.0	-0.02	0.04	1000.0	-1000.0	-0.123	-1000.0
Insulin Pathway	5.0	442.0	74.0	-0.104	0.031	1000.0	-1000.0	-0.122	-1000.0
Signaling events mediated by PRL	5.0	191.0	34.0	-0.126	0.029	1000.0	-1000.0	-0.073	-1000.0
ErbB2/ErbB3 signaling events	4.0	286.0	65.0	-0.077	0.054	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by HDAC Class II	4.0	328.0	75.0	-0.079	0.0	1000.0	-1000.0	-0.07	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	362.0	83.0	-0.07	0.049	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	4.0	430.0	104.0	-0.079	0.041	1000.0	-1000.0	-0.08	-1000.0
EPHB forward signaling	4.0	374.0	85.0	-0.07	0.032	1000.0	-1000.0	-0.105	-1000.0
Arf6 trafficking events	4.0	294.0	71.0	-0.087	0.032	1000.0	-1000.0	-0.091	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	17.0	5.0	-0.008	-0.002	1000.0	-1000.0	-0.045	-1000.0
IFN-gamma pathway	3.0	233.0	68.0	-0.068	0.065	1000.0	-1000.0	-0.124	-1000.0
TCGA08_rtk_signaling	3.0	79.0	26.0	-0.066	0.038	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events	3.0	262.0	73.0	-0.05	0.026	1000.0	-1000.0	-0.093	-1000.0
Regulation of Telomerase	3.0	385.0	102.0	-0.116	0.025	1000.0	-1000.0	-0.117	-1000.0
VEGFR1 specific signals	3.0	208.0	56.0	-0.207	0.044	1000.0	-1000.0	-0.09	-1000.0
p38 MAPK signaling pathway	3.0	159.0	44.0	-0.068	0.034	1000.0	-1000.0	-0.079	-1000.0
Circadian rhythm pathway	2.0	56.0	22.0	-0.03	0.038	1000.0	-1000.0	-0.072	-1000.0
Ceramide signaling pathway	2.0	175.0	76.0	-0.025	0.04	1000.0	-1000.0	-0.081	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	90.0	37.0	-0.01	0.027	1000.0	-1000.0	-0.099	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	131.0	45.0	-0.027	0.061	1000.0	-1000.0	-0.112	-1000.0
PDGFR-beta signaling pathway	2.0	220.0	97.0	-0.04	0.054	1000.0	-1000.0	-0.104	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.034	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.002	0.018	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	1.0	50.0	32.0	-0.057	0.034	1000.0	-1000.0	-0.079	-1000.0
S1P5 pathway	1.0	30.0	17.0	-0.01	0.006	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	1.0	97.0	64.0	-0.089	0.08	1000.0	-1000.0	-0.106	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	45.0	36.0	-0.008	0.02	1000.0	-1000.0	-0.085	-1000.0
Rapid glucocorticoid signaling	1.0	35.0	20.0	-0.008	0.007	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in keratinocytes	1.0	85.0	43.0	-0.022	0.042	1000.0	-1000.0	-0.094	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.036	1000.0	-1000.0	-0.073	-1000.0
Canonical NF-kappaB pathway	0.0	33.0	39.0	-0.019	0.071	1000.0	-1000.0	-0.101	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.052	-1000.0
EPO signaling pathway	0.0	49.0	55.0	-0.008	0.065	1000.0	-1000.0	-0.117	-1000.0
mTOR signaling pathway	0.0	7.0	53.0	-0.003	0.03	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.057	0.043	1000.0	-1000.0	-0.078	-1000.0
ceramide signaling pathway	0.0	45.0	49.0	-0.013	0.043	1000.0	-1000.0	-0.062	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.001	0.027	1000.0	-1000.0	-0.066	-1000.0
Atypical NF-kappaB pathway	0.0	12.0	31.0	-0.002	0.03	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	49.0	76.0	-0.023	0.053	1000.0	-1000.0	-0.105	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.001	0.025	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.0	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	32.0	54.0	-0.023	0.022	1000.0	-1000.0	-0.058	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.001	0.0	1000.0	-1000.0	-0.07	-1000.0
Total	2587	162965	7203	-24.9077794506	-994.758067922	131000	-131000	-11.6255807291	-131000