Correlation between gene mutation status and molecular subtypes
Ovarian Serous Cystadenocarcinoma (Primary solid tumor)
16 April 2014 | analyses__2014_04_16
Maintainer Information
Citation Information
doi:10.7908/C1VX0F5R
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): Correlation between gene mutation status and molecular subtypes. Broad Institute of MIT and Harvard. doi:10.7908/C1VX0F5R
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.

Summary

Testing the association between mutation status of 3 genes and 14 molecular subtypes across 316 patients, no significant finding detected with P value < 0.05 and Q value < 0.25.

- No gene mutations related to molecuar subtypes.

Results
Overview of the results

Table 1. Get Full Table Overview of the association between mutation status of 3 genes and 14 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, no significant finding detected.

|  | Clinical Features | MRNA CNMF | MRNA CHIERARCHICAL | MIR CNMF | MIR CHIERARCHICAL | CN CNMF | METHLYATION CNMF | RPPA CNMF | RPPA CHIERARCHICAL | MRNASEQ CNMF | MRNASEQ CHIERARCHICAL | MIRSEQ CNMF | MIRSEQ CHIERARCHICAL | MIRSEQ MATURE CNMF | MIRSEQ MATURE CHIERARCHICAL
| nMutated (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test
TP53 | 276 (87%) | 40 | 0.814 (1.00) | 0.407 (1.00) | 0.493 (1.00) | 0.367 (1.00) | 0.553 (1.00) | 0.79 (1.00) | 0.393 (1.00) | 0.316 (1.00) | 0.768 (1.00) | 0.882 (1.00) | 0.341 (1.00) | 0.176 (1.00) | 0.15 (1.00) | 0.727 (1.00)
TBP | 4 (1%) | 312 | 1 (1.00) | 0.837 (1.00) | 0.692 (1.00) | 0.596 (1.00) | 0.0365 (1.00) | 0.018 (0.684) | 0.131 (1.00) | 0.872 (1.00) | 1 (1.00) | 1 (1.00) | 0.689 (1.00) | 1 (1.00) | 1 (1.00) | 1 (1.00)
SRC | 4 (1%) | 312 | 0.838 (1.00) | 0.837 (1.00) | 0.566 (1.00) | 0.16 (1.00) | 0.161 (1.00) | 0.464 (1.00) |  |  |  |  | 0.483 (1.00) | 0.325 (1.00) | 0.605 (1.00) | 0.324 (1.00)

'TP53 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.814 (Fisher's exact test), Q value = 1

Table S1. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 119 | 115 | 82
TP53 MUTATED | 105 | 101 | 70
TP53 WILD-TYPE | 14 | 14 | 12

'TP53 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.407 (Fisher's exact test), Q value = 1

Table S2. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 85 | 118 | 113
TP53 MUTATED | 71 | 106 | 99
TP53 WILD-TYPE | 14 | 12 | 14

'TP53 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.493 (Fisher's exact test), Q value = 1

Table S3. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 92 | 96 | 128
TP53 MUTATED | 83 | 81 | 112
TP53 WILD-TYPE | 9 | 15 | 16

'TP53 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.367 (Chi-square test), Q value = 1

Table S4. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6
--- | --- | --- | --- | --- | --- | ---
ALL | 32 | 76 | 75 | 57 | 27 | 49
TP53 MUTATED | 29 | 67 | 68 | 50 | 24 | 38
TP53 WILD-TYPE | 3 | 9 | 7 | 7 | 3 | 11

'TP53 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.553 (Fisher's exact test), Q value = 1

Table S5. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 112 | 103 | 96
TP53 MUTATED | 97 | 93 | 82
TP53 WILD-TYPE | 15 | 10 | 14

'TP53 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.79 (Fisher's exact test), Q value = 1

Table S6. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 90 | 105 | 121
TP53 MUTATED | 80 | 90 | 106
TP53 WILD-TYPE | 10 | 15 | 15

'TP53 MUTATION STATUS' versus 'RPPA_CNMF'

P value = 0.393 (Fisher's exact test), Q value = 1

Table S7. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'RPPA_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 76 | 96 | 38
TP53 MUTATED | 65 | 88 | 33
TP53 WILD-TYPE | 11 | 8 | 5

'TP53 MUTATION STATUS' versus 'RPPA_CHIERARCHICAL'

P value = 0.316 (Fisher's exact test), Q value = 1

Table S8. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'RPPA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 30 | 45 | 52 | 83
TP53 MUTATED | 28 | 41 | 48 | 69
TP53 WILD-TYPE | 2 | 4 | 4 | 14

'TP53 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.768 (Fisher's exact test), Q value = 1

Table S9. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #9: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 70 | 40 | 51
TP53 MUTATED | 60 | 36 | 46
TP53 WILD-TYPE | 10 | 4 | 5

'TP53 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.882 (Fisher's exact test), Q value = 1

Table S10. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #10: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 68 | 66 | 27
TP53 MUTATED | 61 | 57 | 24
TP53 WILD-TYPE | 7 | 9 | 3

'TP53 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.341 (Fisher's exact test), Q value = 1

Table S11. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 79 | 119 | 89
TP53 MUTATED | 65 | 106 | 79
TP53 WILD-TYPE | 14 | 13 | 10

'TP53 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.176 (Fisher's exact test), Q value = 1

Table S12. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 4 | 181 | 102
TP53 MUTATED | 3 | 154 | 93
TP53 WILD-TYPE | 1 | 27 | 9

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.15 (Fisher's exact test), Q value = 1

Table S13. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #13: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 64 | 124 | 99
TP53 MUTATED | 51 | 111 | 88
TP53 WILD-TYPE | 13 | 13 | 11

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.727 (Fisher's exact test), Q value = 1

Table S14. Gene #1: 'TP53 MUTATION STATUS' versus Molecular Subtype #14: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 100 | 5 | 182
TP53 MUTATED | 89 | 5 | 156
TP53 WILD-TYPE | 11 | 0 | 26

'TBP MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S15. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 119 | 115 | 82
TBP MUTATED | 2 | 1 | 1
TBP WILD-TYPE | 117 | 114 | 81

'TBP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.837 (Fisher's exact test), Q value = 1

Table S16. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 85 | 118 | 113
TBP MUTATED | 1 | 1 | 2
TBP WILD-TYPE | 84 | 117 | 111

'TBP MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.692 (Fisher's exact test), Q value = 1

Table S17. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 92 | 96 | 128
TBP MUTATED | 2 | 1 | 1
TBP WILD-TYPE | 90 | 95 | 127

'TBP MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.596 (Chi-square test), Q value = 1

Table S18. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6
--- | --- | --- | --- | --- | --- | ---
ALL | 32 | 76 | 75 | 57 | 27 | 49
TBP MUTATED | 0 | 1 | 1 | 2 | 0 | 0
TBP WILD-TYPE | 32 | 75 | 74 | 55 | 27 | 49

'TBP MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0365 (Fisher's exact test), Q value = 1

Table S19. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 112 | 103 | 96
TBP MUTATED | 4 | 0 | 0
TBP WILD-TYPE | 108 | 103 | 96

Figure S1. Get High-res Image Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'TBP MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.018 (Fisher's exact test), Q value = 0.68

Table S20. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 90 | 105 | 121
TBP MUTATED | 0 | 4 | 0
TBP WILD-TYPE | 90 | 101 | 121

Figure S2. Get High-res Image Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'TBP MUTATION STATUS' versus 'RPPA_CNMF'

P value = 0.131 (Fisher's exact test), Q value = 1

Table S21. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #7: 'RPPA_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 76 | 96 | 38
TBP MUTATED | 3 | 0 | 0
TBP WILD-TYPE | 73 | 96 | 38

'TBP MUTATION STATUS' versus 'RPPA_CHIERARCHICAL'

P value = 0.872 (Fisher's exact test), Q value = 1

Table S22. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #8: 'RPPA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 30 | 45 | 52 | 83
TBP MUTATED | 0 | 0 | 1 | 2
TBP WILD-TYPE | 30 | 45 | 51 | 81

'TBP MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S23. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #9: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 70 | 40 | 51
TBP MUTATED | 1 | 1 | 1
TBP WILD-TYPE | 69 | 39 | 50

'TBP MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S24. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #10: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 68 | 66 | 27
TBP MUTATED | 2 | 1 | 0
TBP WILD-TYPE | 66 | 65 | 27

'TBP MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.689 (Fisher's exact test), Q value = 1

Table S25. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 79 | 119 | 89
TBP MUTATED | 2 | 1 | 1
TBP WILD-TYPE | 77 | 118 | 88

'TBP MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S26. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 4 | 181 | 102
TBP MUTATED | 0 | 3 | 1
TBP WILD-TYPE | 4 | 178 | 101

'TBP MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S27. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #13: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 64 | 124 | 99
TBP MUTATED | 1 | 2 | 1
TBP WILD-TYPE | 63 | 122 | 98

'TBP MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S28. Gene #2: 'TBP MUTATION STATUS' versus Molecular Subtype #14: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 100 | 5 | 182
TBP MUTATED | 1 | 0 | 3
TBP WILD-TYPE | 99 | 5 | 179

'SRC MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.838 (Fisher's exact test), Q value = 1

Table S29. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 119 | 115 | 82
SRC MUTATED | 1 | 2 | 1
SRC WILD-TYPE | 118 | 113 | 81

'SRC MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.837 (Fisher's exact test), Q value = 1

Table S30. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 85 | 118 | 113
SRC MUTATED | 1 | 1 | 2
SRC WILD-TYPE | 84 | 117 | 111

'SRC MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.566 (Fisher's exact test), Q value = 1

Table S31. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 92 | 96 | 128
SRC MUTATED | 0 | 2 | 2
SRC WILD-TYPE | 92 | 94 | 126

'SRC MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.16 (Chi-square test), Q value = 1

Table S32. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6
--- | --- | --- | --- | --- | --- | ---
ALL | 32 | 76 | 75 | 57 | 27 | 49
SRC MUTATED | 1 | 3 | 0 | 0 | 0 | 0
SRC WILD-TYPE | 31 | 73 | 75 | 57 | 27 | 49

'SRC MUTATION STATUS' versus 'CN_CNMF'

P value = 0.161 (Fisher's exact test), Q value = 1

Table S33. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 112 | 103 | 96
SRC MUTATED | 0 | 3 | 1
SRC WILD-TYPE | 112 | 100 | 95

'SRC MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.464 (Fisher's exact test), Q value = 1

Table S34. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 90 | 105 | 121
SRC MUTATED | 0 | 1 | 3
SRC WILD-TYPE | 90 | 104 | 118

'SRC MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.483 (Fisher's exact test), Q value = 1

Table S35. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 79 | 119 | 89
SRC MUTATED | 0 | 1 | 2
SRC WILD-TYPE | 79 | 118 | 87

'SRC MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.325 (Fisher's exact test), Q value = 1

Table S36. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 4 | 181 | 102
SRC MUTATED | 0 | 1 | 2
SRC WILD-TYPE | 4 | 180 | 100

'SRC MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S37. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #13: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 64 | 124 | 99
SRC MUTATED | 0 | 1 | 2
SRC WILD-TYPE | 64 | 123 | 97

'SRC MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.324 (Fisher's exact test), Q value = 1

Table S38. Gene #3: 'SRC MUTATION STATUS' versus Molecular Subtype #14: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 100 | 5 | 182
SRC MUTATED | 2 | 0 | 1
SRC WILD-TYPE | 98 | 5 | 181

Methods & Data
Input

- Mutation data file = transformed.cor.cli.txt

- Molecular subtypes file = OV-TP.transferedmergedcluster.txt

- Number of patients = 316

- Number of significantly mutated genes = 3

- Number of Molecular subtypes = 14

- Exclude genes that fewer than K tumors have mutations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

- Analysis Results (MD5 checksum)

- Auxiliary Data (MD5 checksum)

- MAGE-TAB File (MD5 checksum)

References
[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[2] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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