HotNet pathway analysis of mutation and copy number data
Uterine Carcinosarcoma (Primary solid tumor)
16 April 2014
|
analyses__2014_04_16
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C12R3QC1
Overview
Introduction
Summary
There were 41 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 41 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 41 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| COPB1(28),KDELR1(18),ARCN1(28) | 3 | 0 | 2 |
| F8(26),F9(25),PROS1(31) | 3 | 0 | 2 |
| MTOR(19),EIF3F(26),DKC1(24) | 3 | 0 | 2 |
| PAK4(19),CACNA1D(38),FGFR2(21) | 3 | 0 | 2 |
| TNNT1(19),TNNI3(18),PAPPA(44) | 3 | 0 | 2 |
| BCL2L1(1),AVEN(43),BMF(44) | 3 | 0 | 1 |
| CACNA1B(40),GNB1(20),PDCL(44) | 3 | 0 | 1 |
| EIF4G2(26),NCBP1(44),BNIP3(21) | 3 | 0 | 1 |
| GTF2E2(33),GTF2H1(26),SND1(21) | 3 | 0 | 1 |
| HBA1(33),PTEN(28),ATP6AP1(24) | 3 | 0 | 1 |
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
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