rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(2), IGF1R(3), POLR2A(2), PPP2CA(1), RB1(3), TEP1(10), TERF1(6), TERT(6), TNKS(3), TP53(59), XRCC5(2)	3909142	99	65	80	8	24	10	12	18	34	1	2.32e-05	<1.00e-15	<2.05e-13
2	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(8), CDC25A(3), CDC25C(2), CDK4(2), MYT1(10), RB1(3), TP53(59), YWHAH(1)	2418316	88	64	74	5	19	8	14	17	30	0	4.63e-05	<1.00e-15	<2.05e-13
3	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(8), CCNE1(1), CDK4(2), MDM2(2), RB1(3), TP53(59)	2504477	78	63	67	4	18	7	14	15	24	0	2.74e-05	<1.00e-15	<2.05e-13
4	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(4), AKT1(2), ATM(8), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2), TP53(59)	2904975	82	64	71	5	16	6	14	19	27	0	3.13e-05	1.89e-15	2.30e-13
5	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(7), CDKN2A(22), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1), TP53(59)	2829804	105	64	85	3	19	12	15	15	44	0	4.62e-09	2.55e-15	2.30e-13
6	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(8), ATR(9), CDC25C(2), TP53(59), YWHAH(1)	2182623	79	64	67	5	17	6	12	15	29	0	0.00113	2.55e-15	2.30e-13
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CDK4(2), CDKN2A(22), MDM2(2), NXT1(1), TP53(59)	1183860	87	61	68	1	18	7	12	12	38	0	5.28e-09	3.22e-15	2.30e-13
8	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(7), ATM(8), BRCA1(5), MAPK8(2), MDM2(2), MRE11A(3), NFKBIA(2), RBBP8(9), RELA(1), TP53(59)	4111596	98	69	78	2	19	9	16	15	39	0	2.30e-07	3.55e-15	2.30e-13
9	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(7), ATM(8), ATR(9), CCNA1(3), CCNE1(1), CDC25A(3), CDK4(2), CDK6(2), CDKN2A(22), DHFR(1), GSK3B(1), RB1(3), SKP2(2), TGFB1(1), TGFB2(2), TP53(59)	4177722	126	67	103	11	21	14	20	19	52	0	3.33e-05	4.33e-15	2.30e-13
10	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	SP1(1), TP53(59)	972295	60	60	49	0	15	4	9	11	21	0	6.08e-08	4.55e-15	2.30e-13
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(2), DAXX(4), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1), TP53(59)	2657754	79	61	67	6	21	6	13	15	24	0	5.03e-05	4.66e-15	2.30e-13
12	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), NFKBIA(2), RELA(1), TP53(59)	1382412	65	61	54	1	15	5	10	13	22	0	2.46e-06	4.88e-15	2.30e-13
13	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(3), ATM(8), BAD(1), BCL2L1(7), CASP7(1), CASP9(1), PTK2(4), PXN(1), STAT1(1), TLN1(9), TP53(59)	3786580	97	66	80	5	22	12	14	16	33	0	1.99e-06	5.00e-15	2.30e-13
14	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNGR1(1), IFNGR2(13), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TP53(59), USH1C(3)	2561313	91	64	68	8	20	6	15	14	36	0	0.000525	5.22e-15	2.30e-13
15	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BAK1(1), BCL2L1(7), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), FAS(2), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), PARP1(5), PRF1(6), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TP53(59), TRADD(1), TRAF2(1)	5219351	108	69	87	12	23	9	20	15	40	1	0.000694	1.26e-11	5.15e-10
16	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(8), ATR(9), BRCA1(5), CDC25A(3), CDC25C(2), CDC34(1), EP300(4), MDM2(2), MYT1(10), PRKDC(7), RPS6KA1(2), TP53(59), YWHAH(1)	5804733	113	67	97	12	24	12	16	23	38	0	0.000461	5.04e-10	1.94e-08
17	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(8), ATR(9), BRCA1(5), BRCA2(7), FANCA(3), FANCC(2), FANCD2(4), FANCG(1), HUS1(1), MRE11A(3), RAD1(1), RAD17(5), RAD9A(1), TP53(59), TREX1(2)	6019773	111	69	94	12	22	13	13	25	38	0	0.00116	1.98e-09	7.16e-08
18	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(22), E2F4(4)	1272047	36	23	28	2	2	7	6	4	17	0	0.00487	1.87e-08	6.41e-07
19	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(21), MST1R(5)	903667	29	18	16	4	2	10	1	5	10	1	0.0444	3.03e-07	9.84e-06
20	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(9), HLA-DRB1(1)	414818	10	10	2	1	0	0	0	0	9	1	1.000	1.24e-05	0.000383
21	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), NCK1(3), NCKAP1(4), NTRK1(2), PIR(1), WASF1(1), WASF2(2), WASF3(17), WASL(5)	2102796	42	26	26	5	7	7	3	4	21	0	0.196	4.29e-05	0.00126
22	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(2), EIF4G1(7), EIF4G3(7), GHR(1), IRS1(15), PABPC1(15), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2)	3868264	59	37	32	7	4	8	8	4	35	0	0.290	5.98e-05	0.00167
23	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(1), EGR1(17), HRAS(1), KLK2(1), NGFR(1)	1157008	24	18	12	4	3	0	3	2	16	0	0.813	9.32e-05	0.00250
24	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), IFNGR2(13), JAK1(1), JAK2(2), STAT1(1)	1119538	18	15	6	2	1	0	2	1	14	0	0.732	0.000163	0.00418
25	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), HRAS(1), IGF1R(3), IRS1(15), PIK3CA(4), PIK3R1(1), SHC1(1), SOS1(12), YWHAH(1)	2597719	41	28	20	6	4	4	1	4	28	0	0.562	0.000182	0.00449
26	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BAD(1), BAK1(1), BCL2L1(7), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(2), FASLG(1), HELLS(1), IKBKB(2), IRF1(2), IRF3(1), IRF5(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), NFKBIE(1), PRF1(6), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP53(59), TRADD(1), TRAF2(1)	8075426	130	70	109	15	27	15	22	18	47	1	0.000164	0.000200	0.00473
27	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(12), CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5(3), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(2), PPP2CA(1)	1311578	26	17	16	1	4	4	1	2	15	0	0.0531	0.000254	0.00580
28	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(2), CDK7(1), CDKN2A(22), RB1(3), RBL1(1)	2247796	41	25	31	4	2	7	6	5	21	0	0.0262	0.000362	0.00795
29	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(9), CD4(2), HLA-DRB1(1), IL1B(1), IL6(1)	728807	14	11	6	2	0	0	1	1	11	1	0.839	0.000487	0.0104
30	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(1), SHC1(1), SOS1(12), SRC(2)	1217272	18	15	9	2	2	3	0	1	12	0	0.431	0.000600	0.0123
31	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), HRAS(1), INSR(4), IRS1(15), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1)	3534570	43	29	22	4	5	3	1	5	29	0	0.233	0.000723	0.0144
32	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), PAK1(7), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(5)	1827255	24	17	17	3	2	6	1	3	12	0	0.252	0.00133	0.0257
33	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IFNGR2(13), IL12B(1), IL12RB2(1), IL4R(1), TGFB1(1), TGFB2(2)	2774339	41	27	20	9	4	4	2	5	25	1	0.772	0.00161	0.0300
34	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), HRAS(1), IGF1R(3), IRS1(15), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1)	3427758	42	28	21	5	4	3	1	5	29	0	0.414	0.00179	0.0321
35	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), FSHB(1), FSHR(2), GNAS(13), XPO1(1)	1342998	21	12	17	1	12	2	3	3	1	0	0.0255	0.00183	0.0321
36	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TNFRSF9(7), TNFSF9(19), TRAF2(1)	2706607	38	26	17	5	1	2	4	3	28	0	0.774	0.00207	0.0354
37	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(2), AKT2(1), AKT3(1), BAD(1), BTK(1), CDKN2A(22), DAPP1(1), GSK3A(1), GSK3B(1), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1), TEC(2), YWHAE(2), YWHAH(1)	5012663	66	35	49	9	7	12	4	7	36	0	0.0363	0.00363	0.0604
38	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(7), ATM(8), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(1), CDC25A(3), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), CDKN2A(22), DTX4(1), E2F3(3), E2F4(4), E2F5(3), EP300(4), ESPL1(5), GSK3B(1), HDAC4(4), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), RB1(3), RBL1(1), SKP2(2), SMAD4(17), TBC1D8(2), TGFB1(1), TP53(59)	15310796	213	72	188	17	45	24	36	38	69	1	9.43e-10	0.00522	0.0847
39	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(13), PLA2G3(2), PLA2G6(4)	1414538	20	15	8	6	0	2	3	1	14	0	0.982	0.00599	0.0947
40	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(3), DPYS(9), ENPP3(2), PANK1(1), PANK2(10), PANK4(2), UPB1(2)	1948525	31	19	17	4	3	5	2	2	19	0	0.352	0.00710	0.109
41	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX3(1), ELOVL6(1), FADS1(1), FADS2(13), FASN(7), HADHA(1), HSD17B12(1), SCD(9)	2073110	35	20	16	3	3	4	3	0	24	1	0.123	0.00771	0.116
42	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(10), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1107316	17	12	8	2	3	0	3	1	10	0	0.555	0.00927	0.134
43	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(1), ADORA3(4), LTB4R(4), P2RY1(2), P2RY2(1), P2RY6(1)	823968	14	9	12	1	6	2	2	1	3	0	0.0443	0.00938	0.134
44	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), HRAS(1), INSR(4), IRS1(15), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(1), SOS1(12), SRF(1), STAT5A(1)	4568011	50	31	29	5	8	4	5	4	29	0	0.134	0.0102	0.142
45	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(13), IL12B(1), IL12RB2(1), IL2RA(1), IL4R(1)	1738129	20	17	8	3	1	1	0	3	15	0	0.751	0.0107	0.147
46	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(12), CRY1(1), CSNK1E(1), PER1(4)	1200896	19	12	11	1	3	0	0	3	13	0	0.234	0.0117	0.157
47	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), DPYS(9), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), HIBCH(8), MLYCD(1), UPB1(2)	3729059	49	26	36	5	13	7	9	3	16	1	0.0103	0.0119	0.157
48	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC3B(2), APOBEC3G(1), APOBEC4(9)	1001585	14	10	6	1	3	2	0	0	9	0	0.362	0.0155	0.200
49	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(1), ETS2(2), ETV6(3), ETV7(1), FMN2(7), KRAS(66), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS1(12), SOS2(1)	7375689	141	70	67	28	19	39	44	16	23	0	0.0104	0.0173	0.217
50	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(12)	2146529	25	18	16	3	4	4	1	3	13	0	0.225	0.0187	0.230
51	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4R(1), IRS1(15), JAK1(1), JAK3(3), SHC1(1), STAT6(4)	2066491	27	19	15	9	5	3	2	2	15	0	0.917	0.0191	0.230
52	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(13), GNB1(2), PRKAR1A(1)	938983	20	12	16	2	11	4	2	2	1	0	0.0488	0.0227	0.268
53	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(3), HEXB(2), LCT(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(16), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1)	2267696	38	21	23	7	9	3	3	0	23	0	0.258	0.0298	0.346
54	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(2), EGFR(2), HRAS(1), PTPRB(10), RASA1(1), SHC1(1), SOS1(12), SPRY4(3), SRC(2)	3437199	38	21	27	2	2	8	4	6	17	1	0.0259	0.0309	0.352
55	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2), SHC1(1), TP53(59)	7023440	109	64	91	15	28	13	15	18	35	0	0.00111	0.0315	0.353
56	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(3), DPYS(9), ENPP3(2), ILVBL(2), PANK1(1), PANK2(10), PANK4(2), UPB1(2), VNN1(1)	2416806	35	19	21	4	5	6	3	2	19	0	0.163	0.0397	0.437
57	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(5), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	1321286	16	12	12	4	4	2	2	2	6	0	0.587	0.0458	0.486
58	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(5), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	1321286	16	12	12	4	4	2	2	2	6	0	0.587	0.0458	0.486
59	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD4(2), FYN(8), HLA-DRB1(1), LCK(1), PTPRC(2), ZAP70(5)	1254176	20	11	13	2	3	2	1	2	12	0	0.266	0.0518	0.535
60	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TOB1(4)	1467115	19	12	14	3	7	1	0	2	9	0	0.317	0.0521	0.535
61	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT2(10), CHST2(2), CHST4(1), CHST6(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1751119	23	14	14	2	5	1	4	2	11	0	0.130	0.0580	0.586
62	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(4), ARHGEF1(4), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), MAP3K7(9), PIK3CA(4), PIK3R1(1), PLCB1(1), PPP1R12B(4), ROCK1(3)	3594256	35	22	25	5	4	6	3	4	18	0	0.197	0.0618	0.607
63	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD81(1), CHUK(1), CR2(8), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), KRAS(66), LILRB3(1), MALT1(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(1), SYK(2), VAV1(4)	10358917	179	75	96	26	22	53	41	21	41	1	6.90e-06	0.0620	0.607
64	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	207846	2	2	2	0	0	0	1	0	1	0	0.885	0.0657	0.625
65	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), SHC1(1), SOS1(12)	2690182	32	18	23	4	4	6	5	3	14	0	0.129	0.0659	0.625
66	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(8), CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(3), CDK4(2), CDK7(1), CDKN2A(22), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(4), E2F5(3), GBA2(2), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MYT1(10), NACA(9), POLA2(1), POLE(7), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(2), RPA3(2), TFDP2(3), TNXB(8), TP53(59)	10800979	186	70	163	22	41	23	34	33	54	1	4.49e-07	0.0759	0.708
67	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(13), RANGAP1(2)	1152807	16	8	12	2	1	2	2	4	6	1	0.328	0.0854	0.777
68	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(8), THBS1(3)	1011358	11	11	2	2	3	0	0	0	8	0	0.754	0.0871	0.777
69	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), SNX13(5), SRC(2), TERF2IP(1)	1553443	18	9	18	2	3	2	2	4	7	0	0.189	0.0871	0.777
70	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT2(10), B4GALT5(2), DDOST(1), DPAGT1(5), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), ST6GAL1(1)	2793520	27	18	14	6	4	1	1	4	17	0	0.868	0.0937	0.825
71	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(10), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), ST8SIA1(2)	2277446	26	15	17	2	9	4	2	0	11	0	0.0388	0.0972	0.844
72	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(6), AGT(1), AGTR2(1), KNG1(1), NOS3(6), REN(8)	1397118	23	12	16	2	4	2	7	0	10	0	0.141	0.101	0.865
73	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	948112	13	9	10	3	2	2	3	2	4	0	0.511	0.103	0.873
74	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(5), CSAD(1), GAD1(6), GAD2(5), GGT1(1)	800621	19	12	16	6	4	4	4	1	5	1	0.547	0.105	0.874
75	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(15), ABCG2(1), BCHE(5), CES1(1), CYP3A5(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4)	3108859	33	21	20	7	2	2	3	4	20	2	0.835	0.106	0.874
76	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(1), DAB1(1), FYN(8), LRP8(1), RELN(7), VLDLR(1)	1919142	22	13	13	6	3	2	2	1	13	1	0.908	0.134	1.000
77	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(13), GNB1(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1369153	22	11	18	2	14	4	3	1	0	0	0.0207	0.146	1.000
78	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(8), ATR(9), BAI1(3), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(22), EI24(1), FAS(2), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN2(2), SESN3(2), STEAP3(2), THBS1(3), TNFRSF10B(2), TP53(59), TSC2(6), ZMAT3(2)	9141156	156	67	134	24	38	23	24	21	50	0	0.000184	0.148	1.000
79	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(1), AKT3(1), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1), SOS1(12)	2292231	27	17	18	8	6	2	2	3	14	0	0.774	0.155	1.000
80	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(4), AKT1(2), CAMK2D(1), CREB1(2), GNAS(13), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), RPS6KA5(1), SOS1(12)	4062723	49	27	36	6	16	6	4	5	18	0	0.0430	0.156	1.000
81	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(1), RAB3A(1), RAB4A(1), RAB6A(1), RAB9A(1)	584670	10	4	10	1	5	2	2	1	0	0	0.100	0.166	1.000
82	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(1), AKT3(1), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(66), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(4), PXN(1), RAC2(1), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(1), SRC(2)	10132467	175	73	93	34	23	52	45	18	37	0	0.000657	0.173	1.000
83	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), FGA(5), FGB(4), FGG(2), PLAT(2), PLAU(7), SERPINE1(2)	1835921	24	11	18	7	3	4	4	4	9	0	0.670	0.177	1.000
84	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(8), GAB2(2), HRAS(1), INPP5D(1), KRAS(66), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PRKCD(7), PRKCE(1), RAC2(1), SOS1(12), SOS2(1), SYK(2), VAV1(4)	10032462	163	73	80	28	18	48	40	17	39	1	0.000382	0.179	1.000
85	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), GRM1(13), PLCB1(1), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2215288	30	14	25	5	10	4	3	5	8	0	0.125	0.181	1.000
86	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IL12B(1)	410351	5	5	4	2	0	2	0	0	3	0	0.927	0.184	1.000
87	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(12)	2654117	25	16	16	3	3	4	1	3	14	0	0.219	0.192	1.000
88	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(4), PIK3R1(1), PTK2(4), SRC(2), TERT(6), YWHAH(1)	2309601	27	13	27	4	3	7	2	5	10	0	0.0545	0.192	1.000
89	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), WASF1(1), WASL(5)	1110886	14	9	13	4	2	5	2	2	3	0	0.538	0.209	1.000
90	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR2(1), CMA1(1), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), REN(8)	3503966	38	18	32	2	5	6	11	2	13	1	0.0234	0.215	1.000
91	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(2), FYN(8), ITGA1(7), L1CAM(1), RAP1B(2), SELP(3)	2156792	27	14	20	2	6	5	2	2	12	0	0.0368	0.223	1.000
92	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), CFTR(4), GNAS(13), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1)	1847524	28	14	24	3	14	6	3	4	1	0	0.0142	0.242	1.000
93	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(1), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD17B7(5), HSD3B1(2), HSD3B2(1)	1115313	16	8	13	3	2	10	2	2	0	0	0.0860	0.246	1.000
94	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(4), KLRC3(2), PAK1(7), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4)	2560493	28	14	22	5	5	3	3	5	11	1	0.331	0.261	1.000
95	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(2), GNAS(13), GNB1(2), HRAS(1), IGF1R(3), KLK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(1), SHC1(1), SOS1(12), SRC(2), STAT3(2)	4646209	47	27	34	9	17	8	4	5	13	0	0.113	0.267	1.000
96	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(7), MMP2(2), MMP9(2), RECK(3)	1043179	15	7	11	4	5	1	2	0	7	0	0.570	0.267	1.000
97	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3E(1), HLA-A(4), ICAM1(2), ITGAL(3), ITGB2(1), PRF1(6)	1201508	17	9	15	2	5	1	1	1	9	0	0.191	0.276	1.000
98	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1D(2), EEF1G(3), EEF2(3), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(7), EIF4G3(7), EIF5(1), EIF5B(8), GSPT2(1), PABPC1(15), PABPC3(5), SLC35A4(2)	6128261	69	31	49	8	8	10	14	7	30	0	0.0802	0.278	1.000
99	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F12(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), LPA(5), PLAT(2), PLAU(7), SERPINE1(2), SERPINF2(1), VWF(5)	4853964	50	21	41	9	10	9	15	4	12	0	0.121	0.287	1.000
100	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), HRAS(1), IL3RA(1), JAK2(2), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1)	2441531	24	14	15	3	5	2	3	3	11	0	0.289	0.288	1.000
101	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(1), AKT3(1), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), PTEN(2), RBL2(2), SHC1(1), SOS1(12)	2818091	31	17	22	7	3	4	5	5	14	0	0.569	0.304	1.000
102	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), CCND2(2), CDK4(2), EGR1(17), ESR2(1), FSHR(2), GJA4(1), LHCGR(1), MLH1(1), NCOR1(7), NRIP1(1), PGR(3), PRLR(3), ZP2(1)	4847218	50	22	40	7	8	5	10	9	18	0	0.0886	0.304	1.000
103	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), SNAP25(1)	443254	4	3	4	1	4	0	0	0	0	0	0.520	0.311	1.000
104	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), CDO1(5), GOT1(2), LDHB(1), SULT1B1(4), SULT1C4(1), SULT4A1(1)	1739102	16	9	11	4	1	2	2	3	8	0	0.767	0.312	1.000
105	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(3), CDC25C(2), CSK(1), SRC(2)	1270218	8	7	5	1	1	2	0	0	5	0	0.510	0.318	1.000
106	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB4(4), PSMB5(2), UBE3A(5)	1777146	18	11	16	4	6	0	3	2	7	0	0.499	0.328	1.000
107	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(3), CDC25C(2), MYT1(10), YWHAH(1)	1892958	24	10	21	5	3	4	3	5	9	0	0.419	0.337	1.000
108	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CDH1(1), CREBBP(2), EP300(4), MAP3K7(9), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5)	3530938	34	18	25	6	11	2	3	4	14	0	0.267	0.341	1.000
109	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), JUND(1)	533126	4	4	2	0	0	0	0	1	3	0	0.809	0.345	1.000
110	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(12), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(4), PER2(3), PER3(1)	2380454	27	13	19	3	5	2	2	5	13	0	0.157	0.348	1.000
111	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(3), CASP1(4), CASP10(2), CASP8(2), CASP9(1), PRF1(6)	1768091	21	11	18	5	3	4	1	2	11	0	0.625	0.359	1.000
112	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(2), CES1(1), ESD(1)	826594	9	4	8	1	4	3	2	0	0	0	0.122	0.387	1.000
113	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), NR4A3(7), WDR1(2)	1518294	20	8	15	6	5	2	1	5	7	0	0.607	0.403	1.000
114	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), BCL2L1(7), CASP9(1), CES1(1)	1546282	14	8	8	3	2	3	2	0	7	0	0.733	0.407	1.000
115	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(4), ADCY8(3), ARAF(2), ATF4(1), BRAF(3), CACNA1C(7), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(2), EP300(4), GNAQ(1), GRIA1(3), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRM1(13), GRM5(7), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), RAP1B(2), RAPGEF3(3), RPS6KA1(2), RPS6KA2(1)	13994884	201	76	127	38	39	49	49	23	39	2	9.97e-05	0.435	1.000
116	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADSB(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), DPYS(9), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2)	4003127	44	18	38	4	13	9	9	4	8	1	0.00188	0.435	1.000
117	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	156442	1	1	1	0	0	0	0	0	1	0	0.842	0.458	1.000
118	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PAK1(7), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1)	2804784	26	15	20	6	2	4	6	4	10	0	0.625	0.470	1.000
119	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3)	909411	7	4	7	0	4	0	1	0	2	0	0.150	0.473	1.000
120	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(5), AXIN1(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(8), DVL1(4), FZD1(5), GATA4(1), GSK3B(1), MAP3K7(9), RFC1(4), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), WNT1(1)	5089300	70	24	61	8	25	13	5	11	16	0	0.00128	0.474	1.000
121	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F5(5), FGA(5), FGB(4), FGG(2), PROC(1), PROS1(1), SERPINC1(2), TFPI(3)	2249498	27	9	25	5	3	6	11	5	2	0	0.191	0.475	1.000
122	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BCL2L1(7), BIRC2(1), CASP7(1), CASP8(2), CASP9(1), DFFB(1)	1876439	17	9	11	4	2	3	1	1	10	0	0.705	0.480	1.000
123	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(1), PSMB4(4), PSMB5(2)	1198263	14	10	13	5	4	0	3	1	6	0	0.783	0.480	1.000
124	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(1), CRKL(2), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), SOS1(12), STAT1(1), STAT5A(1)	3878813	34	18	25	6	4	3	5	6	16	0	0.408	0.483	1.000
125	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(9), GNAQ(1), GNAS(13), GNB1(2), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PPP1R12B(4), PTK2(4), ROCK2(1)	3511045	39	23	24	9	11	5	4	3	15	1	0.584	0.496	1.000
126	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(3), CASP1(4), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(7), RERE(9), WWP1(2), WWP2(3)	3324903	42	19	37	9	11	8	3	5	15	0	0.195	0.509	1.000
127	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(5), AXIN1(5), CD14(2), CTNNB1(8), DVL1(4), FZD1(5), GNAI1(1), GSK3B(1), LBP(1), LEF1(3), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1), TOLLIP(1), WNT1(1)	4297741	48	16	47	5	14	9	5	12	8	0	0.00292	0.510	1.000
128	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4)	1762032	13	6	13	1	2	4	0	3	3	1	0.0591	0.511	1.000
129	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRB1(1)	325957	3	2	3	1	0	0	0	1	2	0	0.905	0.514	1.000
130	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(5), AXIN1(5), BTRC(1), CREBBP(2), CSNK1D(1), CSNK2A1(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), MAP3K7(9), NLK(1), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1)	4141671	50	19	43	5	14	8	7	8	13	0	0.00535	0.520	1.000
131	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(6), CD44(3), CSF1(2), IL1B(1), IL6R(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3)	1885145	23	10	19	7	6	1	5	4	7	0	0.565	0.521	1.000
132	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), ESCO2(8), SH3GLB1(1)	2273332	16	11	9	4	1	1	1	3	10	0	0.854	0.527	1.000
133	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BFAR(2), BTK(1), CAD(5), CASP10(2), CASP8(2), DAXX(4), DEDD(1), EGFR(2), EPHB2(3), FAF1(1), FAIM2(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(6), RALBP1(2), ROCK1(3), TP53(59), TPX2(2), TRAF2(1)	10265077	144	71	114	23	27	17	24	23	53	0	0.00562	0.533	1.000
134	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(8), BMPR1A(3), BMPR2(3)	858608	14	5	14	3	2	6	2	1	3	0	0.337	0.543	1.000
135	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RETN(3)	792995	9	4	7	1	2	0	2	1	4	0	0.399	0.552	1.000
136	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(6), ACE2(1), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(4), LNPEP(2), MME(2), NLN(1), REN(8), THOP1(1)	2922558	34	15	27	4	4	8	8	4	10	0	0.0409	0.555	1.000
137	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(5), GLS(2), GOT1(2)	1072483	11	3	11	0	2	2	2	3	1	1	0.0398	0.556	1.000
138	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), HADHB(2), HSD17B4(3), PPT1(1), PPT2(2)	1170613	10	4	10	0	2	3	1	2	2	0	0.0548	0.557	1.000
139	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(2), ANXA1(2), GNAS(13), GNB1(2), NOS3(6), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(1)	2525460	33	15	29	5	11	5	8	5	4	0	0.0937	0.564	1.000
140	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1), UGP2(5), UXS1(1)	677287	7	5	6	2	0	1	1	3	2	0	0.823	0.567	1.000
141	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(7), ABL2(3), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), BTC(1), CAMK2D(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EGF(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GSK3B(1), HRAS(1), KRAS(66), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), NCK1(3), NCK2(2), NRG1(5), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SRC(2), STAT5A(1)	14387581	207	70	127	28	36	53	47	20	51	0	1.38e-06	0.575	1.000
142	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2D(1), PAK1(7), PTK2(4), SHC1(1), SOS1(12), SRC(2)	4656530	41	18	26	8	3	5	6	5	22	0	0.554	0.579	1.000
143	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(1), B3GNT5(1), FUT1(1), FUT2(3), ST3GAL4(2)	993382	9	6	9	2	8	0	0	1	0	0	0.289	0.585	1.000
144	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(1), EPOR(2), GRIN1(7), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1)	1773893	16	8	11	1	2	1	5	0	8	0	0.203	0.586	1.000
145	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	98584	2	1	2	1	2	0	0	0	0	0	0.803	0.596	1.000
146	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), STAT1(1), STAT3(2), STAT5A(1), THPO(1)	4123193	29	16	20	3	3	6	2	3	15	0	0.127	0.608	1.000
147	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(7), ARFGEF2(2), CLTB(2), COPA(2), GBF1(3), GPLD1(2), KDELR3(1)	2223789	21	10	16	4	4	2	3	3	8	1	0.414	0.612	1.000
148	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(4), AKT1(2), BAD(1), BCL2L1(7), CSF2RB(2), IGF1R(3), IL3RA(1), KIT(4), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1)	3032682	36	13	30	5	8	7	3	6	12	0	0.0415	0.621	1.000
149	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2)	1401634	14	5	14	1	9	2	2	0	1	0	0.0241	0.622	1.000
150	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(4), SIRT1(1)	1632389	11	6	9	0	3	1	1	2	4	0	0.106	0.623	1.000
151	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAP3K7(9), MAPK8(2), PAK1(7), PAK2(3), PRKDC(7), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1)	5426888	56	23	43	8	12	2	11	7	24	0	0.168	0.623	1.000
152	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(13), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2157409	31	13	27	3	14	7	3	3	4	0	0.00686	0.633	1.000
153	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), YWHAH(1)	1962071	16	8	16	4	0	4	4	3	5	0	0.447	0.635	1.000
154	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), AKT1(2), AKT2(1), AKT3(1), APAF1(3), ATM(8), BAD(1), BCL2L1(7), BIRC2(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CSF2RB(2), DFFB(1), FAS(2), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IL3RA(1), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TP53(59), TRADD(1), TRAF2(1)	11700600	151	70	132	21	38	22	19	23	49	0	9.01e-05	0.638	1.000
155	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(2), OAT(2), PRODH(1)	783236	9	3	9	1	2	1	2	1	3	0	0.214	0.643	1.000
156	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), EPO(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1)	2997076	28	13	19	3	6	2	4	3	13	0	0.156	0.650	1.000
157	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1), STAT1(1), STAT3(2), STAT5A(1)	4823694	38	18	29	6	6	6	4	6	16	0	0.218	0.652	1.000
158	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(1), AKT3(1), IARS(4), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(4), SHC1(1), SOS1(12), SOS2(1), SRC(2), STAT6(4), TYK2(2)	5126144	42	19	33	8	8	7	5	6	16	0	0.200	0.655	1.000
159	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(2), ABCB4(4), ABCC3(4), GSTP1(1)	1969378	15	9	12	3	2	3	2	4	4	0	0.418	0.656	1.000
160	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1)	830758	11	3	11	2	1	2	1	4	3	0	0.375	0.662	1.000
161	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	224782	3	1	3	0	1	1	0	1	0	0	0.348	0.679	1.000
162	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(1), NFS1(1), PHPT1(1), TPK1(2)	881786	6	3	6	2	1	2	2	0	1	0	0.780	0.679	1.000
163	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(3), INPPL1(5), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2)	2721003	23	12	21	5	3	4	3	5	8	0	0.367	0.687	1.000
164	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), KEAP1(1), MAFF(2), MAPK8(2), NFE2L2(1)	1253790	8	4	8	0	2	0	0	3	3	0	0.115	0.689	1.000
165	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(2), DFFB(1), NME1(1), PRF1(6), SET(1)	1470883	12	8	10	2	3	1	1	1	6	0	0.464	0.694	1.000
166	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(1), AKT3(1), CARD11(3), CBL(4), CBLB(1), CD3E(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), CTLA4(1), FYN(8), GRAP2(2), HRAS(1), IKBKB(2), ITK(1), KRAS(66), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS1(12), SOS2(1), TEC(2), VAV1(4), ZAP70(5)	14110931	222	78	119	31	30	57	44	22	68	1	1.25e-05	0.695	1.000
167	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), F10(4), F12(2), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1)	6151124	59	20	53	8	7	11	21	5	14	1	0.0683	0.699	1.000
168	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(1)	274454	1	1	1	0	1	0	0	0	0	0	0.782	0.703	1.000
169	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDK7(1)	971537	4	4	2	1	0	0	0	0	4	0	0.899	0.706	1.000
170	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD80(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1)	1747533	12	6	12	2	1	2	2	2	5	0	0.325	0.706	1.000
171	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	305620	2	1	2	1	0	0	0	1	1	0	0.765	0.708	1.000
172	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(4), CDC25C(2), GNAI1(1), GNAS(13), GNB1(2), HRAS(1), MYT1(10), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), SRC(2)	2890315	47	20	42	7	20	11	6	6	4	0	0.00619	0.710	1.000
173	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(3), CACNA1A(7), GNA11(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAS(13), GNAZ(1), GRIA1(3), GRID2(4), GRM1(13), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), IGF1R(3), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), NOS1(7), NOS3(6), NPR1(2), NPR2(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(18)	15461334	224	77	151	40	59	45	64	30	26	0	1.05e-05	0.713	1.000
174	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1), PRF1(6)	2669345	28	12	25	4	5	6	4	1	12	0	0.196	0.719	1.000
175	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(3), FUT5(1), FUT6(1)	707432	6	3	6	1	5	1	0	0	0	0	0.233	0.726	1.000
176	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(2), CPOX(3), HMBS(1), PPOX(2)	1059298	8	6	8	2	2	2	1	1	2	0	0.626	0.726	1.000
177	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1)	2642202	23	11	23	3	5	6	3	2	7	0	0.0735	0.730	1.000
178	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2)	1027752	11	3	11	1	3	4	3	0	1	0	0.167	0.734	1.000
179	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1), HLA-DRB1(1)	544056	4	2	4	1	0	0	1	1	2	0	0.845	0.735	1.000
180	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFLAR(2)	529164	4	2	4	3	0	0	1	1	2	0	0.908	0.735	1.000
181	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	256508	1	1	1	0	0	0	0	1	0	0	0.796	0.738	1.000
182	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(3), CDC25C(2), CDK7(1), XPO1(1)	1204201	7	5	4	2	1	0	0	0	6	0	0.884	0.738	1.000
183	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(11), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM1(13), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM7(5), GRM8(3)	2881720	61	26	49	13	11	14	7	7	22	0	0.134	0.741	1.000
184	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1), STAT1(1), STAT3(2), STAT5A(1)	5172602	39	18	30	6	4	7	4	7	17	0	0.193	0.743	1.000
185	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(3), GCNT2(2), ST8SIA1(2)	864472	8	3	8	1	5	2	1	0	0	0	0.123	0.745	1.000
186	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(2), TAT(1), TYR(3)	641413	7	2	7	3	1	1	3	2	0	0	0.814	0.746	1.000
187	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LPL(2)	727176	7	2	7	1	1	3	1	1	1	0	0.228	0.746	1.000
188	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), SOS1(12), STAT5A(1), SYK(2)	3289113	28	14	19	9	8	4	1	3	12	0	0.741	0.753	1.000
189	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), CD38(1), ENPP3(2), NADK(7), NADSYN1(4), NNT(5), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT12(1)	2977376	29	11	22	4	6	4	3	3	13	0	0.187	0.753	1.000
190	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ENPP3(2), FLAD1(5), RFK(1), TYR(3)	1335629	12	5	9	2	3	3	1	1	4	0	0.424	0.772	1.000
191	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BRAF(3), FAS(2), FASLG(1), FCGR3B(1), FYN(8), HLA-A(4), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), ITGAL(3), ITGB2(1), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), KRAS(66), LCK(1), NCR1(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK1(7), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRF1(6), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), ZAP70(5)	15802910	246	78	128	34	37	55	41	25	87	1	8.59e-06	0.775	1.000
192	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2)	775721	13	4	12	2	5	2	3	0	3	0	0.134	0.777	1.000
193	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(6), TH(1), TPH1(2)	850064	9	3	9	4	2	0	3	1	2	1	0.744	0.778	1.000
194	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(2), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), ESCO2(8), GCDH(2), HADHA(1), SH3GLB1(1)	3574631	24	13	17	5	4	3	3	3	11	0	0.549	0.781	1.000
195	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR39(3), GPR65(2), GPR75(1)	1354180	10	5	10	3	1	1	0	4	4	0	0.736	0.783	1.000
196	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), BCL2L1(7), CASP9(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1)	2687776	25	13	19	6	2	5	3	4	11	0	0.597	0.786	1.000
197	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), ESCO1(3), ESCO2(8), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TAT(1), TPO(4)	4725962	46	18	38	9	18	5	6	5	12	0	0.0813	0.793	1.000
198	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1)	1832313	14	7	14	3	4	3	1	3	3	0	0.245	0.805	1.000
199	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), EPO(1), IL6(1), IL7(1), IL9(1)	854176	8	2	8	1	0	1	2	4	1	0	0.388	0.812	1.000
200	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(1), CD4(2)	439716	3	1	3	1	0	0	0	1	2	0	0.839	0.823	1.000
201	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2)	1861052	11	5	10	4	1	2	1	3	4	0	0.782	0.825	1.000
202	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(2), EP300(4), IKBKB(2), IL1B(1), MAP2K6(2), MAP3K7(9), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(5), TGFBR2(5), TLR2(2)	4127875	39	17	31	6	10	5	6	4	14	0	0.0909	0.827	1.000
203	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGP2(5), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), XYLB(2)	3716054	27	13	24	5	3	6	5	4	9	0	0.353	0.828	1.000
204	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(2), ERBB3(4), NRG1(5), UBE2D1(1)	1412586	14	4	14	1	3	2	4	2	3	0	0.110	0.830	1.000
205	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(2), EP300(4), FYN(8), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1)	3893283	29	18	21	9	6	4	3	3	13	0	0.694	0.833	1.000
206	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CALML3(2), CALML6(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(2), CTNNB1(8), DCT(5), DVL1(4), DVL2(3), EDN1(3), EDNRB(2), EP300(4), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAS(13), GSK3B(1), HRAS(1), KIT(4), KRAS(66), LEF1(3), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACG(2), PRKCG(2), TCF7(2), TCF7L1(3), TCF7L2(1), TYR(3), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2)	15398834	223	72	154	51	65	55	49	29	25	0	1.96e-05	0.839	1.000
207	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), IL6(1)	860541	9	2	9	1	1	1	1	3	3	0	0.263	0.850	1.000
208	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(4), EGF(2), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(1), SRC(2)	2667516	23	9	21	2	4	6	3	3	7	0	0.0482	0.850	1.000
209	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(2), ADSS(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), CAD(5), CRAT(6), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), PC(2)	3607511	43	16	38	10	9	8	12	5	8	1	0.187	0.857	1.000
210	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), SLC2A1(4)	3501189	30	12	28	5	5	5	9	2	8	1	0.260	0.857	1.000
211	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(3), CR2(8), FCGR2B(1), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2)	2087015	22	13	20	4	5	4	1	5	7	0	0.208	0.859	1.000
212	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	572133	1	1	1	0	0	0	0	0	1	0	0.829	0.859	1.000
213	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(4)	1639934	22	5	22	6	9	3	5	1	3	1	0.226	0.860	1.000
214	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(3)	880183	6	2	6	1	1	0	3	1	1	0	0.435	0.862	1.000
215	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1)	2472306	22	6	22	2	7	3	7	3	1	1	0.0285	0.866	1.000
216	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(3), CASP9(1), DAXX(4), FAS(2), FASLG(1), MAPKAPK3(1)	1567330	16	7	14	5	3	4	3	2	4	0	0.598	0.868	1.000
217	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1)	1749661	11	5	9	0	1	3	0	1	6	0	0.0930	0.868	1.000
218	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1)	1721928	23	6	23	6	5	6	5	4	3	0	0.311	0.870	1.000
219	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1438872	6	3	6	1	2	0	2	1	1	0	0.402	0.871	1.000
220	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1438872	6	3	6	1	2	0	2	1	1	0	0.402	0.871	1.000
221	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(1)	937796	19	5	18	3	7	6	0	2	4	0	0.0316	0.873	1.000
222	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(1), FLT3(3), IL6(1), IL9(1), TGFB1(1), TGFB2(2)	1162588	10	4	9	2	1	2	4	1	2	0	0.433	0.876	1.000
223	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(1), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2)	1240198	11	3	11	2	2	1	3	4	1	0	0.352	0.876	1.000
224	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPX1(1), PRKCE(1)	1090308	13	2	13	1	4	4	1	1	2	1	0.0342	0.877	1.000
225	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(5), AOC3(2), CES1(1), DDHD1(2), ESCO1(3), ESCO2(8), LIPA(1), PLA1A(1), SH3GLB1(1)	3487308	24	14	16	5	6	4	2	3	9	0	0.388	0.883	1.000
226	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(4), GNAQ(1), GNB1(2), MYLK(8), PLCB1(1), PPP1R12B(4), ROCK1(3)	2849035	26	10	23	7	4	6	4	4	8	0	0.473	0.889	1.000
227	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), CREB1(2), EDN1(3), EP300(4), EPO(1), HIF1A(1), NOS3(6)	2358032	20	6	19	2	4	2	5	2	7	0	0.123	0.889	1.000
228	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	232415	1	1	1	1	0	0	1	0	0	0	0.968	0.890	1.000
229	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), AFMID(1), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1)	1833613	12	5	10	1	2	3	0	1	6	0	0.196	0.891	1.000
230	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(13), ABAT(1), ADSL(2), ADSS(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(1), CAD(5), CRAT(6), DARS(1), DARS2(1), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), NARS2(2), PC(2), PDHA1(1)	5246618	67	26	55	14	13	12	14	7	20	1	0.120	0.891	1.000
231	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), PRF1(6), SCAP(3), SREBF1(1), SREBF2(5)	2600541	26	11	22	6	5	6	1	1	13	0	0.362	0.892	1.000
232	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(1), SHMT2(2)	590029	4	2	4	4	2	0	1	0	0	1	0.923	0.895	1.000
233	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(4), ESR1(1), SRC(2)	2080195	9	4	9	1	2	3	2	1	1	0	0.145	0.897	1.000
234	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), ESCO2(8), SH3GLB1(1)	3430068	31	11	24	9	5	7	3	5	11	0	0.610	0.898	1.000
235	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(4), GNAS(13), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2)	2102491	29	12	25	4	14	3	4	6	2	0	0.0538	0.898	1.000
236	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(4), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(4), SPHK1(1), SRC(2)	3777430	31	10	31	2	5	11	3	5	7	0	0.00165	0.898	1.000
237	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1)	2405184	17	8	15	4	3	2	4	2	6	0	0.604	0.903	1.000
238	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(1), HK2(3), HK3(2), PGM1(2), PGM3(1)	1415027	10	3	10	4	4	1	2	0	3	0	0.526	0.905	1.000
239	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), PGM3(1), RENBP(1), UAP1(1)	2349416	20	7	20	6	8	3	5	1	3	0	0.353	0.906	1.000
240	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), OPRK1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1789927	11	4	11	2	5	1	3	0	2	0	0.294	0.906	1.000
241	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TAT(1), TPO(4)	3048453	36	11	35	8	17	5	7	3	4	0	0.0591	0.907	1.000
242	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA5A(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), GLUD2(1), HAL(1)	2925016	22	9	21	4	4	8	3	1	5	1	0.163	0.907	1.000
243	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAPK8(2), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2), TOLLIP(1)	4134060	32	15	24	8	5	2	5	5	15	0	0.658	0.910	1.000
244	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(1), STAT3(2), STAT5A(1)	1675462	12	4	12	2	6	2	2	0	2	0	0.176	0.911	1.000
245	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(2), GNAQ(1), GNAS(13), GRM1(13), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), HTR2A(2), HTR2B(1), HTR2C(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), MAP3K2(2), MAPK7(4), NPR1(2), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACG(2), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(12), SOS2(1), SRC(2), TJP1(4), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1)	18444478	252	79	170	41	62	65	57	30	38	0	3.01e-08	0.911	1.000
246	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), EGFR(2), EP300(4), ERBB2(6), FARP2(1), FER(6), FYN(8), IGF1R(3), INSR(4), IQGAP1(1), LEF1(3), LMO7(5), MAP3K7(9), MET(4), MLLT4(4), NLK(1), PARD3(6), PTPN6(4), PTPRB(10), PTPRF(20), PTPRJ(2), PTPRM(6), PVRL1(13), PVRL2(11), PVRL3(1), PVRL4(1), RAC2(1), RHOA(1), SMAD3(1), SMAD4(17), SORBS1(1), SRC(2), SSX2IP(1), TCF7(2), TCF7L1(3), TCF7L2(1), TGFBR1(5), TGFBR2(5), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASF3(17), WASL(5), YES1(1)	16557979	244	66	174	25	49	33	25	29	107	1	1.03e-05	0.913	1.000
247	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNB1(2), HTR2C(1), PLCB1(1), TUB(2)	981132	7	3	7	2	0	4	0	2	1	0	0.416	0.913	1.000
248	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1), UQCRH(1)	5276444	41	16	41	8	10	6	7	10	7	1	0.111	0.914	1.000
249	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(2), TPO(4)	1603550	21	4	21	6	9	3	4	2	2	1	0.232	0.915	1.000
250	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2), KARS(2)	644905	4	2	4	3	1	0	1	1	1	0	0.952	0.917	1.000
251	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS2(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	2070401	19	5	19	4	2	5	8	2	2	0	0.266	0.920	1.000
252	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNAS(13), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5)	3230534	40	15	36	5	19	7	5	4	5	0	0.00596	0.921	1.000
253	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNAS(13), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5)	3230534	40	15	36	5	19	7	5	4	5	0	0.00596	0.921	1.000
254	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA5A(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), HAL(1)	2614983	20	8	19	3	4	6	3	1	5	1	0.150	0.922	1.000
255	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(2), CHST12(1), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1)	1290043	14	6	14	3	3	2	2	4	3	0	0.346	0.923	1.000
256	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(2), MAP2K6(2), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1), SP1(1)	2691532	19	8	19	8	1	2	6	4	6	0	0.890	0.924	1.000
257	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(2), SHC1(1), SOS1(12), SYK(2), VAV1(4)	4488736	32	15	23	8	8	3	3	4	13	1	0.535	0.924	1.000
258	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(4), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1971277	19	6	19	5	7	3	6	2	1	0	0.340	0.924	1.000
259	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(1)	630082	3	1	3	2	1	1	0	0	1	0	0.818	0.925	1.000
260	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), FARS2(2), GOT1(2), TAT(1)	1129552	8	4	7	2	0	2	3	2	1	0	0.580	0.929	1.000
261	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1)	2418149	29	8	29	8	6	6	6	6	5	0	0.315	0.930	1.000
262	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(2), ARSE(1), CYP11B1(5), CYP11B2(4), HSD11B1(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1)	3763565	34	18	28	10	8	6	5	2	13	0	0.626	0.933	1.000
263	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), MAP3K1(3), MAP3K7(9), NFKBIA(2), RELA(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	3424893	24	11	17	8	3	2	7	3	9	0	0.914	0.934	1.000
264	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1)	3744303	27	13	25	4	4	4	3	5	11	0	0.271	0.935	1.000
265	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB4(4), PSMB5(2), PSMD1(2), PSMD11(1), PSMD12(2)	2189571	18	9	17	8	5	1	4	3	5	0	0.876	0.935	1.000
266	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1)	3558924	27	9	27	5	7	7	7	4	1	1	0.0852	0.936	1.000
267	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	1216347	10	3	9	0	1	2	2	2	3	0	0.118	0.937	1.000
268	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(1), PFKL(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2)	1289033	15	3	15	4	5	6	1	2	1	0	0.170	0.937	1.000
269	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(2), CREBBP(2), EP300(4), NCOA3(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2855594	19	6	19	6	6	3	4	2	3	1	0.430	0.938	1.000
270	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(4), MEF2A(2), MEF2D(1), YWHAH(1)	1099767	11	2	11	3	1	2	5	1	2	0	0.534	0.938	1.000
271	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	1485591	12	5	12	2	7	2	2	0	1	0	0.108	0.939	1.000
272	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	294107	3	1	3	0	0	1	2	0	0	0	0.408	0.939	1.000
273	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), MUT(2)	684217	3	1	3	2	0	0	0	1	2	0	0.905	0.944	1.000
274	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(1), CDKN2A(22), DAPP1(1), FLOT1(1), FLOT2(2), ITPR1(6), ITPR2(9), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(6), PREX1(8), PTEN(2), PTPRC(2), RPS6KA1(2), RPS6KA2(1), SYK(2), TEC(2), VAV1(4)	7708394	91	37	79	14	20	14	10	12	34	1	0.00343	0.946	1.000
275	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1104732	5	3	5	2	3	0	2	0	0	0	0.673	0.946	1.000
276	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1104732	5	3	5	2	3	0	2	0	0	0	0.673	0.946	1.000
277	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(9), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), HIBCH(8), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2)	5458860	43	16	36	8	14	6	6	4	13	0	0.138	0.946	1.000
278	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GGT1(1), SHMT1(1), SHMT2(2)	779743	5	3	5	4	2	1	1	0	0	1	0.875	0.946	1.000
279	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(1), FBXW7(4), RB1(3)	1151734	10	3	10	4	1	3	2	3	1	0	0.759	0.946	1.000
280	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2)	965411	9	4	9	3	3	2	0	2	2	0	0.696	0.947	1.000
281	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(2), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTH1(3), FTMT(2), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	5790895	39	18	35	7	5	10	4	5	15	0	0.196	0.947	1.000
282	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1)	1472641	12	4	12	2	6	1	0	2	3	0	0.154	0.949	1.000
283	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPHN(1), SRC(2), UBQLN1(3)	1665425	19	4	19	2	6	4	4	2	2	1	0.0346	0.950	1.000
284	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ATF4(1), CACNA1C(7), CACNA1D(14), CACNA1F(1), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(13), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), LHB(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(7), MMP2(2), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(3), PRKACG(2), PRKCD(7), SOS1(12), SOS2(1), SRC(2)	17933519	249	80	155	46	48	58	56	28	56	3	2.58e-05	0.950	1.000
285	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(4), APOA4(2), APOC1(1), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(3), LPL(2), LRP1(12), SCARB1(1), SOAT1(1)	3769470	32	11	32	9	13	7	3	2	6	1	0.148	0.953	1.000
286	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(2), ANXA6(2), CYP11A1(2), EDN1(3), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(3), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	2883118	27	11	26	7	12	2	4	5	4	0	0.271	0.953	1.000
287	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(1), DHRS3(2), PON1(1), PON2(1)	2502339	24	8	23	6	8	4	2	5	5	0	0.256	0.954	1.000
288	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(1), AKT3(1), BRD4(5), CBL(4), CDC42(1), CDKN2A(22), F2RL2(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPPL1(5), IRS1(15), IRS2(3), IRS4(3), LNPEP(2), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SORBS1(1), SOS1(12), SOS2(1), YWHAE(2), YWHAH(1)	8315734	109	50	77	22	12	17	10	11	59	0	0.249	0.955	1.000
289	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1)	1544248	14	4	14	3	6	1	0	3	4	0	0.256	0.955	1.000
290	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), UGDH(1)	1183983	6	3	6	3	3	0	2	1	0	0	0.766	0.958	1.000
291	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), MAP3K7(9), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	3841112	29	12	22	8	6	2	6	4	11	0	0.650	0.958	1.000
292	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(8), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1)	2342244	25	9	25	8	10	5	7	1	2	0	0.280	0.960	1.000
293	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(2)	1611423	9	4	9	2	3	1	2	0	3	0	0.482	0.961	1.000
294	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	359143	3	1	3	1	0	1	1	1	0	0	0.760	0.961	1.000
295	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), MAF(2), NFATC1(4), NFATC2(5), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1728743	19	5	18	7	8	5	2	0	4	0	0.283	0.961	1.000
296	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), GREB1(4), MTA1(1), PDZK1(1), TUBA8(4)	1552600	12	4	12	2	0	8	1	1	2	0	0.0728	0.963	1.000
297	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3)	856979	9	2	9	3	3	0	1	2	3	0	0.580	0.964	1.000
298	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ENPP3(2), FLAD1(5), MTMR2(1), MTMR6(1), PHPT1(1), RFK(1), TYR(3)	2072626	15	5	12	5	4	4	2	1	4	0	0.741	0.965	1.000
299	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1), FOSL2(2), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(1), TNFRSF11A(2)	1538193	11	2	11	3	0	2	3	5	1	0	0.525	0.965	1.000
300	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(1), HMGB1(1), TOP2A(1), TOP2B(4)	1285166	8	4	8	2	3	2	0	1	2	0	0.606	0.966	1.000
301	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(9), FASN(7), MCAT(1), OLAH(2)	2276042	23	6	22	3	8	6	2	1	5	1	0.0193	0.967	1.000
302	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1B(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	1952302	17	4	17	5	2	5	7	1	2	0	0.487	0.967	1.000
303	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(3), DDC(1), GAD1(6), GAD2(5), SLC18A3(2), TH(1), TPH1(2)	2034870	23	9	23	9	7	2	9	2	2	1	0.554	0.967	1.000
304	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), LEPR(5), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2)	1979071	14	3	14	1	0	6	1	2	5	0	0.0548	0.967	1.000
305	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(4), DDX20(1), E2F4(4), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(5)	3697332	28	10	26	8	5	8	5	4	6	0	0.358	0.967	1.000
306	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CYP2C9(1), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), ESCO2(8), HADHA(1), SH3GLB1(1)	4261309	26	14	19	8	7	1	4	3	11	0	0.798	0.968	1.000
307	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), PC(2), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(2)	2837228	23	6	22	2	5	4	6	4	4	0	0.0423	0.971	1.000
308	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(5), AXIN1(5), BTRC(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NOTCH1(7), PSEN1(1), WNT1(1)	3072054	41	8	41	7	15	13	4	6	3	0	0.00664	0.971	1.000
309	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(4), CTNNB1(8), PTK2(4), PXN(1), SRC(2), VCL(1)	2699126	32	7	32	5	14	10	2	5	1	0	0.00823	0.971	1.000
310	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(2), SCAP(3), SREBF1(1), SREBF2(5)	1732184	11	6	9	9	2	2	0	2	5	0	0.985	0.972	1.000
311	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(2), NAT2(1), XDH(6)	1085665	16	6	16	7	6	2	1	4	3	0	0.736	0.972	1.000
312	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3)	2866339	32	8	32	8	7	6	6	7	6	0	0.224	0.972	1.000
313	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), LCT(3), PGM1(2), PYGM(1), TPI1(2), TREH(1)	1870812	10	3	10	9	1	2	1	1	5	0	0.940	0.972	1.000
314	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(7), ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), ATM(8), ATR(9), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25A(3), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(22), CREBBP(2), CUL1(1), E2F3(3), EP300(4), ESPL1(5), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(2), SMAD3(1), SMAD4(17), SMC1A(1), SMC1B(2), TGFB1(1), TGFB2(2), TP53(59), YWHAE(2), YWHAH(1)	18896234	231	74	205	28	47	32	39	35	77	1	9.45e-07	0.972	1.000
315	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(5)	1455959	14	3	13	1	5	3	3	1	2	0	0.0620	0.973	1.000
316	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(1)	462012	3	1	3	0	0	3	0	0	0	0	0.378	0.974	1.000
317	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(5), CARM1(1), CREBBP(2), EP300(4), ERCC3(8), ESR1(1), GRIP1(1), GTF2E1(1), GTF2F1(4), HDAC4(4), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(3)	6548221	44	20	35	9	9	7	5	4	19	0	0.284	0.975	1.000
318	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	1195423	7	3	7	4	3	0	2	0	2	0	0.792	0.975	1.000
319	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(3), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	1816641	15	5	14	3	5	2	2	2	4	0	0.345	0.976	1.000
320	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(1), CARM1(1), CYP11B1(5), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD17B7(5), HSD3B1(2), HSD3B2(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	6908049	60	25	50	13	9	19	13	5	14	0	0.106	0.978	1.000
321	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(3), OGDH(3), SDHA(3), SUCLA2(1)	1289002	11	2	11	1	3	1	3	2	2	0	0.144	0.979	1.000
322	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(2)	1495890	8	3	8	3	3	0	3	2	0	0	0.634	0.979	1.000
323	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4)	424787	6	2	6	2	1	1	1	3	0	0	0.698	0.979	1.000
324	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
325	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
326	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
327	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(2), BECN1(1), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(2), ULK3(1)	2944437	21	7	21	4	5	4	1	7	4	0	0.193	0.981	1.000
328	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(2), DHFR(1), FTCD(3), MTFMT(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	2612027	23	6	21	6	4	3	4	5	6	1	0.356	0.982	1.000
329	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MANBA(2), NEU4(1)	2329794	15	7	15	4	6	1	2	0	6	0	0.380	0.983	1.000
330	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), SHC1(1)	4722675	37	12	37	6	10	8	9	2	8	0	0.0247	0.983	1.000
331	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1)	1903223	7	2	7	3	0	2	1	2	2	0	0.627	0.984	1.000
332	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), BCL2L1(7), CBL(4), CFLAR(2), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), IRS1(15), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1), SYK(2)	5040401	66	40	39	14	9	7	6	7	37	0	0.690	0.984	1.000
333	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(5), CREBBP(2), CTNNB1(8), DVL1(4), EP300(4), FZD1(5), GSK3B(1), LDB1(1), LEF1(3), TRRAP(9), WNT1(1)	4599247	48	11	47	8	17	9	6	11	5	0	0.0116	0.986	1.000
334	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), KERA(2), LUM(1)	496834	4	1	4	1	0	0	1	3	0	0	0.674	0.986	1.000
335	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(1), VKORC1(3)	1554661	16	3	16	6	3	5	6	1	1	0	0.524	0.986	1.000
336	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP7(1), CASP8(2), CFLAR(2), DAXX(4), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(9), MAPK8(2), PAK1(7), PAK2(3), PRKDC(7), PTPN13(6), RB1(3), SPTAN1(3)	5698541	60	25	45	14	6	3	11	11	29	0	0.756	0.987	1.000
337	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(10), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), HSD3B7(3), LCT(3), MGAM(1), PFKL(2), PFKM(2), PGM1(2), PGM3(1), RDH11(2), UGP2(5)	5384964	46	20	36	12	13	5	6	4	18	0	0.351	0.987	1.000
338	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(2), EIF4B(3), EIF4G1(7), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2), TSC1(1), TSC2(6)	3818174	40	15	39	10	9	10	10	5	6	0	0.266	0.987	1.000
339	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1)	2211453	13	4	13	4	2	2	5	2	2	0	0.564	0.987	1.000
340	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), FURIN(2), NOTCH1(7), PSEN1(1)	1369260	13	2	13	6	6	6	1	0	0	0	0.336	0.987	1.000
341	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(1), MC2R(2), MC3R(3), MC5R(2), NPY1R(2), NPY2R(3), NPY5R(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), SSTR1(4), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3)	7252236	83	27	74	21	23	9	21	12	16	2	0.0617	0.987	1.000
342	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), NOS1(7), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	3580533	45	15	40	12	15	6	6	7	11	0	0.242	0.988	1.000
343	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(2), RPL10A(1), RPL10L(2), RPL11(1), RPL18(2), RPL18A(1), RPL22L1(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(2), RPL3L(2), RPS11(2), RPS25(1), RPS27(1), RPS28(1), RPSA(1)	3143933	25	10	23	7	7	2	4	0	12	0	0.742	0.988	1.000
344	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(1), HK2(3), HK3(2), ISYNA1(1), PGM1(2), PGM3(1)	1628441	11	3	11	5	5	1	2	0	3	0	0.550	0.988	1.000
345	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(1), AKT3(1), BAD(1), BCL2L1(7), CDC42(1), CDKN2A(22), CREB1(2), ERBB4(6), F2RL2(2), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(5), IRS1(15), IRS2(3), IRS4(3), MET(4), NOLC1(4), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTEN(2), PTK2(4), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1), TSC1(1), TSC2(6), YWHAE(2), YWHAH(1)	10779909	150	58	103	31	18	17	17	15	83	0	0.350	0.988	1.000
346	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(2)	1252099	11	2	10	5	2	1	5	1	2	0	0.871	0.988	1.000
347	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), PRKACG(2), PRKAR2B(1)	1392069	7	2	7	3	1	2	2	1	1	0	0.830	0.988	1.000
348	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GLS(2), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(1)	4582693	44	12	44	10	8	7	14	6	7	2	0.167	0.988	1.000
349	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), OGDHL(2), PC(2), PCK1(3), PCK2(4), SDHA(3), SUCLA2(1), SUCLG1(2)	4103283	34	9	32	6	11	4	7	4	7	1	0.0865	0.989	1.000
350	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(10), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGP(2), PIGQ(5), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(16), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1)	6794388	78	34	53	10	21	10	9	4	34	0	0.00983	0.989	1.000
351	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TPO(4), TYR(3)	1340179	19	5	19	8	9	0	5	2	3	0	0.696	0.990	1.000
352	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CAPNS1(3), CAPNS2(1), EP300(4), MEF2D(1), NFATC1(4), NFATC2(5), PPP3CA(1), PPP3CC(2)	3357673	25	10	24	8	5	6	0	4	10	0	0.494	0.990	1.000
353	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), EHHADH(1), HADHA(1)	1681105	7	3	7	2	4	0	3	0	0	0	0.510	0.990	1.000
354	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), DCT(5), DDC(1), GOT1(2), HGD(2), HPD(2), TAT(1), TH(1), TPO(4), TYR(3)	4393947	48	12	47	16	20	8	8	6	6	0	0.210	0.990	1.000
355	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	BCMO1(2)	530069	2	1	2	0	1	0	0	1	0	0	0.530	0.990	1.000
356	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(5), ODC1(1), SAT2(1)	4104870	25	8	24	3	11	5	5	2	1	1	0.0180	0.991	1.000
357	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELP(3)	2203724	15	5	15	5	5	3	1	3	3	0	0.374	0.991	1.000
358	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(8), HMGCS2(1), HSD17B4(3), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	5950900	46	14	39	8	10	9	9	4	14	0	0.0856	0.991	1.000
359	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2)	1446344	12	4	12	3	4	2	1	3	2	0	0.297	0.991	1.000
360	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1830349	19	3	19	7	7	5	4	2	1	0	0.470	0.992	1.000
361	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKL(2), PFKM(2), PGD(1), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1), TKTL1(1)	3371012	25	6	25	6	6	5	8	2	4	0	0.136	0.992	1.000
362	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1), TPI1(2)	532396	4	1	4	0	1	2	0	1	0	0	0.218	0.992	1.000
363	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2)	1652444	10	4	10	6	3	2	3	0	2	0	0.856	0.993	1.000
364	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5E(1), NT5M(1)	2009279	16	2	16	3	5	4	2	3	2	0	0.144	0.994	1.000
365	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(1), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGP(2), PIGQ(5), PIGS(3), PIGW(2)	3323504	23	7	22	3	6	4	4	4	5	0	0.0555	0.994	1.000
366	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), GGT1(1), PAPSS1(3), PAPSS2(3), SCLY(2)	1715261	11	4	11	9	4	2	2	1	2	0	0.945	0.994	1.000
367	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G3(2), PLA2G6(4), RDH11(2)	3298698	28	7	28	9	7	3	9	6	3	0	0.592	0.994	1.000
368	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGAL(3), ITGB2(1), SELE(2)	1665164	11	4	11	5	4	1	1	3	2	0	0.675	0.994	1.000
369	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(1), TLR2(2), TLR4(1), TLR7(1), TLR9(5)	2560893	21	7	21	7	8	5	3	5	0	0	0.408	0.995	1.000
370	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), HAL(1), PRPS1(1)	3371480	19	9	18	5	8	5	4	1	1	0	0.198	0.995	1.000
371	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAPK8(2), NFKBIA(2), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(2), TLR4(1), TLR6(3), TLR7(1), TLR9(5), TOLLIP(1)	5075234	44	18	37	10	11	4	8	7	14	0	0.356	0.995	1.000
372	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(1), ASL(1), ASS1(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(1), GOT1(2), LAP3(2), NOS1(7), NOS3(6), OAT(2), P4HA1(5), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	5011975	58	17	58	12	17	10	16	8	6	1	0.0643	0.996	1.000
373	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKM(2), PGD(1), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1)	2827695	22	4	22	7	5	4	8	2	3	0	0.294	0.996	1.000
374	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(1), AKT3(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS1(15), IRS2(3), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS1(12), SOS2(1), STAT6(4)	5171604	59	30	38	15	10	10	4	6	29	0	0.619	0.996	1.000
375	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(4), PRL(4), TRH(2)	1556587	14	6	14	5	7	1	2	2	2	0	0.529	0.996	1.000
376	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(1), FDFT1(2), GGCX(1), HMGCR(3), HSD17B7(5), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1), VKORC1(3)	2692991	22	9	19	8	4	9	7	1	1	0	0.409	0.996	1.000
377	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NEU4(1)	2869103	18	7	18	6	8	1	2	0	7	0	0.428	0.997	1.000
378	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1), HADHA(1)	668241	2	1	2	0	1	0	1	0	0	0	0.545	0.997	1.000
379	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PDHA1(1), PKLR(2)	5092832	37	8	36	8	9	14	4	3	7	0	0.0811	0.997	1.000
380	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG5(1), ALG9(1), B4GALT2(10), DDOST(1), DHDDS(1), DOLPP1(2), DPAGT1(5), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1)	5934197	48	21	35	10	10	7	5	7	19	0	0.376	0.997	1.000
381	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CREB1(2), GNAI1(1), GNAQ(1), GNAS(13), GNB1(2), HRAS(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	4896298	49	18	44	10	19	11	4	6	9	0	0.0415	0.997	1.000
382	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), AGTR2(1), EDN1(3), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1)	2828007	16	4	15	1	2	3	4	1	6	0	0.0461	0.997	1.000
383	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	146	APC(5), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(2), CSNK1A1L(3), CSNK1E(1), CSNK2A1(1), CTBP2(5), CTNNB1(8), CUL1(1), CXXC4(13), DAAM1(7), DAAM2(5), DKK2(1), DKK4(1), DVL1(4), DVL2(3), EP300(4), FBXW11(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), LEF1(3), LRP5(6), LRP6(4), MAP3K7(9), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP3CA(1), PPP3CC(2), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(3), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD3(1), SMAD4(17), SOX17(1), TCF7(2), TCF7L1(3), TCF7L2(1), TP53(59), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2)	22809677	322	81	269	59	82	43	35	54	108	0	3.44e-05	0.997	1.000
384	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), LCT(3), NAGLU(2)	2042627	15	7	15	7	4	3	1	2	5	0	0.697	0.998	1.000
385	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3)	2943836	32	8	32	10	7	6	6	7	6	0	0.387	0.998	1.000
386	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3)	1894860	12	5	12	5	6	3	1	1	1	0	0.572	0.998	1.000
387	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3)	767714	12	1	12	4	4	3	2	2	1	0	0.501	0.998	1.000
388	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(9), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), CALML3(2), CALML6(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EXOC7(1), FASN(7), FBP2(1), FLOT1(1), FLOT2(2), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), GYS2(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS1(15), IRS2(3), IRS4(3), KRAS(66), LIPE(1), MAPK10(1), MAPK8(2), MAPK9(1), PCK1(3), PCK2(4), PDE3A(8), PDE3B(1), PFKL(2), PFKM(2), PHKA2(2), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAG3(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PTPRF(20), PYGB(2), PYGM(1), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOCS4(2), SORBS1(1), SOS1(12), SOS2(1), SREBF1(1), TRIP10(2), TSC1(1), TSC2(6)	22595972	280	82	180	65	55	69	47	27	80	2	0.00245	0.998	1.000
389	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(9), CYP27A1(3), CYP7A1(2), HADHB(2)	3218750	35	15	28	12	8	5	7	3	12	0	0.731	0.998	1.000
390	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(2), NOS1(7), NOS3(6), OAT(2), ODC1(1), P4HA1(5), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1)	6159133	62	18	61	9	23	12	16	6	4	1	0.00151	0.998	1.000
391	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(2), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), NAGK(1), PPAT(2), QARS(1)	5459691	48	12	48	12	8	9	15	7	7	2	0.191	0.998	1.000
392	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(1), ACAT1(2), HADHA(1)	747818	5	1	5	0	0	4	1	0	0	0	0.194	0.998	1.000
393	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	HSD3B7(3), RDH11(2)	669383	5	1	5	0	1	0	2	2	0	0	0.288	0.998	1.000
394	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(6), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1F(1), ERO1L(1), GNAS(13), PDIA4(1), PLCG1(1), PLCG2(6), SEC61A1(1), SEC61A2(2), SEC61G(1)	5129390	49	13	45	13	20	8	10	7	4	0	0.139	0.998	1.000
395	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(2), ACVR1C(1), ACVR2A(7), ACVRL1(1), AMH(1), AMHR2(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(4), CREBBP(2), CUL1(1), DCN(1), E2F4(4), E2F5(3), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), RBL1(1), RBL2(2), RHOA(1), ROCK1(3), ROCK2(1), RPS6KB2(2), SKP1(1), SMAD3(1), SMAD4(17), SMAD7(1), SMAD9(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), THBS1(3), THBS2(4), THBS4(21), ZFYVE16(4), ZFYVE9(3)	13851215	145	49	119	26	30	22	20	20	53	0	0.0248	0.998	1.000
396	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(7), CACNA1B(9), GNAS(13), GNB1(2), GNB3(2), GNG13(1), GRM4(1), ITPR3(8), KCNB1(5), PLCB2(4), PRKACG(2), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(5), TAS1R2(3), TAS1R3(2), TAS2R1(2), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R9(2), TRPM5(1)	8102105	93	30	86	18	39	12	14	11	17	0	0.00188	0.998	1.000
397	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(2), SYNJ2(2)	3082711	18	5	18	7	3	4	2	4	5	0	0.683	0.999	1.000
398	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(5), AXIN1(5), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(8), DVL1(4), DVL2(3), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(7), PPP2R5C(2), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PRKD1(2), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2)	8471618	99	35	86	27	34	18	6	15	26	0	0.0985	0.999	1.000
399	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(4), ILVBL(2), LARS2(2), PDHA1(1), VARS(2), VARS2(2)	2567615	16	4	16	5	6	4	2	3	1	0	0.499	0.999	1.000
400	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CD4(2), CREB1(2), CTSB(2), CTSS(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), HSP90AA1(7), HSP90AB1(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1), TAP2(1), TAPBP(1)	6459776	52	23	49	14	7	12	6	10	17	0	0.396	0.999	1.000
401	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(4), SRC(2), SYK(2), TBXAS1(1)	3367745	23	4	23	8	6	8	3	4	2	0	0.535	0.999	1.000
402	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(3), F2RL1(1), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(1), PLD2(3), PLD3(1), PTK2(4), RASAL1(5), SRC(2), TEC(2), VAV1(4)	3839257	37	5	37	8	10	12	6	3	5	1	0.0430	0.999	1.000
403	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), OGT(1), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1)	4445385	27	8	27	8	8	5	7	4	3	0	0.352	0.999	1.000
404	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFAT5(21), PDE6B(3), PDE6C(1), SLC6A13(1)	4986565	55	26	34	12	10	7	7	2	29	0	0.542	0.999	1.000
405	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6)	6224212	54	15	52	11	18	8	4	11	13	0	0.0647	0.999	1.000
406	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(2), AKT1(2), CDC42(1), FLNA(8), FLNC(9), FSCN3(2), GDI2(2), LIMK1(1), MYH2(3), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), ROCK1(3), ROCK2(1), VASP(1), WASF1(1), WASL(5)	6696386	65	24	58	17	10	12	14	11	18	0	0.355	0.999	1.000
407	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(2), MAP3K1(3), NCOR2(4), THRA(2), THRB(1)	2435338	14	5	14	9	3	3	3	2	3	0	0.950	0.999	1.000
408	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	691247	1	1	1	1	1	0	0	0	0	0	0.845	0.999	1.000
409	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), BDH1(1), DDHD1(2), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2)	5625967	44	12	44	10	11	11	11	8	2	1	0.0696	0.999	1.000
410	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TKTL1(1), TPI1(2)	2788686	21	4	21	2	3	5	8	2	3	0	0.0377	0.999	1.000
411	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(7), ITGB3(1), PTK2(4), PXN(1), SPTAN1(3), SRC(2), TLN1(9)	3967938	41	8	41	6	13	12	6	4	6	0	0.00453	0.999	1.000
412	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(2), YWHAH(1)	2825938	17	4	17	5	4	3	3	3	4	0	0.454	0.999	1.000
413	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SP1(1)	2902362	21	5	20	6	4	6	2	3	6	0	0.347	0.999	1.000
414	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(3), SP1(1)	913204	5	1	5	0	1	0	3	1	0	0	0.352	0.999	1.000
415	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(3), ARHGAP6(3), ARHGEF1(4), ARHGEF11(4), ARHGEF5(2), ARPC1A(1), ARPC2(1), ARPC3(1), BAIAP2(3), DIAPH1(4), GSN(6), LIMK1(1), MYLK(8), PIP5K1B(2), PPP1R12B(4), ROCK1(3), SRC(2), TLN1(9), VCL(1)	6383751	63	21	56	18	15	16	10	7	15	0	0.230	0.999	1.000
416	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(8), MAP2(3), PPP1CA(1), PPP2CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1)	2493140	17	5	17	6	5	4	2	4	2	0	0.671	0.999	1.000
417	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(3), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(8), NCF2(1), PAK1(7), PDGFRA(3), PIK3CA(4), PIK3R1(1), PPP1R12B(4), RALBP1(2), TRIO(9), VAV1(4), WASF1(1)	4825060	53	21	41	11	11	9	5	6	20	2	0.271	0.999	1.000
418	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(2), KARS(2)	949040	6	2	6	3	1	0	3	1	1	0	0.905	0.999	1.000
419	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(9), DGAT1(3), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GLB1(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PPAP2B(2)	6749799	68	21	61	22	26	7	9	8	18	0	0.339	0.999	1.000
420	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(3), NR1H4(1)	744421	4	2	4	2	1	2	1	0	0	0	0.621	0.999	1.000
421	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	2115781	18	6	18	9	10	1	3	1	3	0	0.784	1.000	1.000
422	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(9), DGAT1(3), DGAT2(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), GK2(4), GLB1(3), GPAM(3), LCT(3), LIPA(1), LIPF(2), LIPG(3), LPL(2), MGLL(2), PNLIP(1), PPAP2B(2)	8191634	84	24	77	26	30	11	14	11	18	0	0.229	1.000	1.000
423	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(4), FYN(8), GSN(6), HRAS(1), ITGA1(7), MYLK(8), PIK3CA(4), PIK3R1(1), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9)	5148203	62	23	51	11	13	15	8	7	19	0	0.0414	1.000	1.000
424	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2D(1), CDK5(3), FYN(8), GNA11(2), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(2), MYLK(8), PLCG1(1), SHC1(1), SOS1(12), STAT1(1), STAT3(2), STAT5A(1)	5773068	52	26	34	12	8	8	6	5	25	0	0.556	1.000	1.000
425	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TPI1(2)	2500132	22	3	22	2	3	6	8	3	2	0	0.0222	1.000	1.000
426	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(12), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(1), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(2), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(1)	7780400	75	27	69	18	17	12	11	14	20	1	0.170	1.000	1.000
427	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SGMS1(2), SGPP1(1), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(1)	5034998	33	9	32	10	13	6	3	6	5	0	0.181	1.000	1.000
428	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), CARM1(1), DDC(1), FTCD(3), HAL(1), HARS2(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), UROC1(4)	5495100	42	13	40	8	12	11	11	3	5	0	0.0291	1.000	1.000
429	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(10), FBP2(1), GAA(2), GANAB(2), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), LCT(3), MGAM(1), PFKM(2), PGM1(2), PGM3(1)	4531688	35	17	26	11	10	2	6	1	16	0	0.621	1.000	1.000
430	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(2), JAK1(1), JAK2(2), JAK3(3), STAT1(1), STAT3(2), STAT5A(1), TYK2(2)	2581639	16	6	16	8	7	2	4	1	2	0	0.748	1.000	1.000
431	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(1), AKT3(1), ASAH1(1), BRAF(3), DAG1(2), EGFR(2), EPHB2(3), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), RGS20(1), SHC1(1), SOS1(12), SOS2(1), SRC(2), STAT3(2), TERF2IP(1)	8144495	76	33	63	11	15	10	9	10	32	0	0.0463	1.000	1.000
432	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(4), CCKBR(3), CCR2(1), CCR3(9), CELSR1(3), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(2), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(6), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GRM1(13), GRPR(1), LGR6(2), LPHN2(6), LPHN3(1), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(2), TSHR(3)	9325716	98	31	87	25	31	16	16	14	20	1	0.0379	1.000	1.000
433	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(1), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	3408012	29	6	29	7	7	5	9	4	4	0	0.254	1.000	1.000
434	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(4), LPL(2), NCOA2(2), PPARG(1)	2535211	11	4	11	9	4	1	2	1	3	0	0.976	1.000	1.000
435	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTTN(1), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(2), HRAS(1), IGSF5(1), JAM2(1), KRAS(66), LLGL1(5), LLGL2(2), MAGI1(2), MAGI2(7), MAGI3(1), MLLT4(4), MPDZ(2), MRAS(2), MYH1(5), MYH10(24), MYH11(5), MYH13(2), MYH14(4), MYH15(6), MYH2(3), MYH3(1), MYH4(5), MYH6(6), MYH7(6), MYH7B(8), MYH8(4), MYH9(2), MYLPF(1), PARD3(6), PARD6A(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP2R3A(5), PPP2R3B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PTEN(2), RAB13(1), RHOA(1), SPTAN1(3), SRC(2), SYMPK(7), TJP1(4), TJP2(5), TJP3(4), YES1(1)	27034758	308	80	218	64	65	69	65	43	66	0	0.000142	1.000	1.000
436	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(2), LDHB(1)	942061	3	1	3	2	1	0	1	1	0	0	0.935	1.000	1.000
437	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(3), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), SHC1(1), SOS1(12), SOS2(1), SYK(2), VAV1(4)	7356111	76	38	50	16	15	11	5	8	36	1	0.306	1.000	1.000
438	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1)	998288	5	1	5	1	0	4	0	0	1	0	0.365	1.000	1.000
439	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	2453807	17	2	17	5	3	2	4	4	3	1	0.392	1.000	1.000
440	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(1), PFKL(2), PFKM(2), PLCG1(1), PRKCE(1)	3540443	18	4	18	4	3	7	3	2	3	0	0.149	1.000	1.000
441	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(7), ABLIM1(5), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CDK5(3), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(3), EFNA1(1), EPHA1(3), EPHA2(4), EPHA3(1), EPHA4(2), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(8), EPHB2(3), EPHB3(3), EPHB4(5), EPHB6(5), FYN(8), GNAI1(1), GNAI2(2), GSK3B(1), HRAS(1), KRAS(66), L1CAM(1), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NGEF(6), NRP1(2), NTN4(1), NTNG1(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(1), PPP3CA(1), PPP3CC(2), PTK2(4), RAC2(1), RASA1(1), RGS3(1), RHOA(1), RHOD(1), RND1(1), ROBO1(6), ROBO2(3), ROBO3(5), ROCK1(3), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(5), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(3), SEMA4G(2), SEMA5A(4), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(5), SLIT2(4), SLIT3(6), SRGAP1(5), SRGAP2(2), SRGAP3(7), UNC5A(6), UNC5B(2), UNC5C(4), UNC5D(10)	27722621	378	86	262	87	82	77	71	46	101	1	0.00157	1.000	1.000
442	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	2870998	16	3	16	7	3	1	5	3	4	0	0.862	1.000	1.000
443	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(4), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(4), MAP2K6(2), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(5), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), YWHAH(1)	4844684	44	12	43	12	11	9	5	6	13	0	0.195	1.000	1.000
444	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(4), FH(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), PC(2), PDHA1(1), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(2)	3930041	29	4	29	5	8	4	8	4	5	0	0.0897	1.000	1.000
445	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), EHHADH(1), GCDH(2), HADHA(1)	1073881	6	1	6	0	2	2	2	0	0	0	0.130	1.000	1.000
446	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1)	3114139	15	3	15	7	1	4	6	2	2	0	0.864	1.000	1.000
447	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2)	1149350	7	1	7	0	1	3	1	0	2	0	0.101	1.000	1.000
448	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREBBP(2), CRKL(2), DAG1(2), EGR1(17), EGR2(3), EGR3(1), GNAQ(1), MAP1B(4), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SRC(2), TERF2IP(1), TH(1)	7293433	73	36	61	24	15	9	9	9	31	0	0.753	1.000	1.000
449	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(3), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2)	5846368	41	6	41	10	14	11	7	4	5	0	0.0598	1.000	1.000
450	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(9), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(2), SOAT1(1)	4413324	47	16	40	14	11	8	11	5	12	0	0.456	1.000	1.000
451	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), FYN(8), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5)	7251970	75	28	65	12	18	13	8	12	24	0	0.0216	1.000	1.000
452	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), FYN(8), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5)	7251970	75	28	65	12	18	13	8	12	24	0	0.0216	1.000	1.000
453	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(2), AKT2(1), AKT3(1), APC(5), AXIN1(5), AXIN2(1), CTNNB1(8), DACT1(3), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(12), MVP(3), NKD1(3), NKD2(1), PSEN1(1), SENP2(1), SFRP1(2), WIF1(2)	5691860	60	17	60	14	21	12	10	8	9	0	0.0592	1.000	1.000
454	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3)	3212961	16	7	15	9	5	3	3	3	2	0	0.876	1.000	1.000
455	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), CARM1(1), DCT(5), DDC(1), ESCO1(3), ESCO2(8), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TPO(4), TYR(3)	8221564	77	21	69	21	23	14	15	9	16	0	0.163	1.000	1.000
456	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1)	1142547	5	2	5	2	0	1	2	1	1	0	0.774	1.000	1.000
457	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), CHRNA1(3), FLT1(3), FLT4(9), KDR(1), NOS3(6), PDE2A(1), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1)	5693089	58	18	55	10	20	10	12	3	13	0	0.00897	1.000	1.000
458	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(2), CPO(2), HBB(1), HMBS(1)	1126737	6	4	6	4	3	1	1	0	1	0	0.851	1.000	1.000
459	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP11(2), AKAP12(2), AKAP3(2), AKAP4(1), AKAP6(4), AKAP7(2), AKAP9(8), ARHGEF1(4), GNA11(2), GNA14(1), GNA15(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(6), KRAS(66), PALM2(2), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PRKD1(2), PRKD3(3), RHOA(1)	16268033	195	73	126	48	42	52	50	26	23	2	0.00362	1.000	1.000
460	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PCK2(4), PDHA1(1), PKLR(2)	6441941	52	14	50	13	17	14	4	3	13	1	0.0887	1.000	1.000
461	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(1), CAPNS1(3), CAPNS2(1), EGF(2), EGFR(2), HRAS(1), ITGA1(7), MYLK(8), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(4), PXN(1), TLN1(9)	4568671	49	7	49	9	16	14	8	6	5	0	0.00740	1.000	1.000
462	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), ASAH1(1), CAMP(2), CERK(1), CREB1(2), DAG1(2), EPHB2(3), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1)	4025765	34	8	34	10	10	4	4	7	9	0	0.317	1.000	1.000
463	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(2), AKT2(1), AKT3(1), ARHGAP4(1), ARHGEF11(4), BTK(1), CDC42(1), GDI2(2), INPPL1(5), ITPR1(6), ITPR2(9), ITPR3(8), LIMK1(1), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), PTEN(2), RACGAP1(2), ROCK1(3), ROCK2(1), WASF1(1), WASL(5)	9750327	92	31	79	26	17	18	17	10	30	0	0.392	1.000	1.000
464	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2)	4556690	26	4	26	4	7	6	6	5	2	0	0.0898	1.000	1.000
465	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CSK(1), CTLA4(1), DAG1(2), EPHB2(3), FBXW7(4), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(1), SOS1(12), SOS2(1), VAV1(4), ZAP70(5)	7845919	92	38	60	12	18	13	8	8	44	1	0.0501	1.000	1.000
466	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), PON1(1)	4052828	42	12	40	14	15	5	8	7	7	0	0.409	1.000	1.000
467	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(1), CRKL(2), DOCK1(2), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PAK1(7), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), PXN(1), RAP1B(2), RASA1(1), SOS1(12), SRC(2), STAT3(2)	6204579	64	25	49	14	9	16	6	8	25	0	0.268	1.000	1.000
468	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(2), SPTLC2(1), UGCG(1)	3398444	19	4	19	7	7	5	1	1	5	0	0.384	1.000	1.000
469	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK2(3), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SOS1(12), SYK(2), VAV1(4)	5947854	59	20	49	14	11	12	6	9	20	1	0.286	1.000	1.000
470	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), DFFB(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(3), TNFRSF10B(2), TNFSF12(1), TRADD(1), TRAF2(1)	4682039	28	6	28	7	8	5	5	2	8	0	0.247	1.000	1.000
471	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(1), GOT1(2), TAT(1)	1195184	6	3	5	2	1	1	3	1	0	0	0.744	1.000	1.000
472	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(9), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), PRIM1(1), RFC1(4), RFC2(1), RFC3(1), RPA1(1), RPA2(2), RPA3(2), RPS27A(1), UBB(1)	7019158	57	17	57	14	16	7	14	9	10	1	0.195	1.000	1.000
473	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLG(4), POLH(1), POLI(1), POLK(3), POLL(2), POLM(3), POLQ(2), PRIM1(1), REV1(1), REV3L(3)	5643269	35	8	34	5	7	6	7	10	5	0	0.0457	1.000	1.000
474	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CHUK(1), DAXX(4), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	6839344	55	20	47	17	12	7	9	9	18	0	0.571	1.000	1.000
475	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(5), AR(3), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(2), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2)	7462220	66	23	61	16	16	7	10	9	24	0	0.241	1.000	1.000
476	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), BCL2L1(7), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(4), DFFB(1), FAS(2), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(6), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	6087655	58	18	48	15	11	10	11	5	21	0	0.519	1.000	1.000
477	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(4), LARS2(2), PDHA1(1)	1369898	9	3	9	3	3	2	1	3	0	0	0.597	1.000	1.000
478	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(1), FYN(8), HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), PTPN7(1), RASA1(1), RELA(1), SHC1(1), SOS1(12), VAV1(4), ZAP70(5)	6635119	69	27	52	11	11	12	8	9	28	1	0.0760	1.000	1.000
479	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(6), PSEN1(1)	1254241	10	2	10	3	1	5	1	2	1	0	0.523	1.000	1.000
480	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(2), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGAM4(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2)	8023443	66	11	66	18	24	15	12	5	10	0	0.0574	1.000	1.000
481	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SOS1(12), SYK(2), VAV1(4)	5291350	46	15	36	12	9	9	3	7	17	1	0.432	1.000	1.000
482	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), LPO(4), MPO(2), TPO(4)	1163833	14	4	14	5	8	0	3	1	2	0	0.510	1.000	1.000
483	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(5), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), RYR1(18)	6404613	60	19	56	15	22	5	11	7	15	0	0.158	1.000	1.000
484	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(1), C1QA(1), C1QC(1), C1R(1), C1S(4), C3(6), C3AR1(2), C5(1), C5AR1(1), C6(6), C7(4), C8A(5), C9(1), CD46(1), CD55(1), CD59(2), CFB(6), CFD(1), CFH(4), CFI(3), CR1(3), CR2(8), F10(4), F12(2), F13A1(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(3), PLAT(2), PLAU(7), PLAUR(6), PROC(1), PROS1(1), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(3), THBD(3), VWF(5)	12501194	136	41	119	34	29	21	26	23	37	0	0.173	1.000	1.000
485	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL2(1), CUL3(1), FBXW11(1), FBXW7(4), ITCH(2), SKP1(1), SKP2(2), TCEB1(1), TCEB2(1), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(3)	5575104	38	10	37	10	11	9	6	6	6	0	0.322	1.000	1.000
486	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(1), GTF2E2(2), GTF2F1(4), GTF2H1(1), GTF2H4(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(7), TAF1L(3), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(3), TAF6(1), TAF6L(3), TAF7L(1)	4963264	39	16	35	12	8	3	9	6	13	0	0.850	1.000	1.000
487	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(3), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(2), RDH11(2), SETD1A(17), SETDB1(2), SHMT1(1), SHMT2(2), SUV39H2(2)	8064679	68	28	49	19	16	7	13	6	25	1	0.570	1.000	1.000
488	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), APOA5(3), AQP7(4), CPT1B(4), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(1), CYP7A1(2), CYP8B1(1), EHHADH(1), FABP4(1), FADS2(13), GK2(4), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(4), PLTP(1), PPARA(1), PPARD(1), PPARG(1), SCD(9), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(1), SORBS1(1), UCP1(1)	9036825	90	30	70	16	21	18	15	5	30	1	0.0177	1.000	1.000
489	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(6), ARRB2(2), CALML3(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(1), CNGB1(10), GUCA1A(1), GUCA1C(1), PDC(1), PRKACG(2), PRKG1(1), PRKG2(1)	4229394	37	13	32	13	12	5	9	3	8	0	0.661	1.000	1.000
490	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK1(7), PLCG1(1), SHC1(1), SOS1(12), SRC(2)	3966035	36	20	21	12	4	5	3	4	20	0	0.939	1.000	1.000
491	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(1), KYNU(1), TDO2(1), TPH1(2), WARS(2)	7580798	58	14	56	18	19	8	16	9	6	0	0.336	1.000	1.000
492	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), CLOCK(12), CRY1(1), DNAJA1(1), ETV6(3), GFRA1(3), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(4), PER2(3), PURA(1), TOB1(4), TUBB3(1), UCP3(1), UGP2(5), ZFR(1)	5092245	52	21	39	17	10	5	4	11	22	0	0.870	1.000	1.000
493	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2)	6724999	54	7	54	16	19	12	10	5	8	0	0.123	1.000	1.000
494	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2)	6724999	54	7	54	16	19	12	10	5	8	0	0.123	1.000	1.000
495	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(3), ESR1(1), ESR2(1), ESRRA(2), NR0B1(1), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(3), PPARA(1), PPARD(1), PPARG(1), RARB(2), RARG(2), ROR1(3), RORA(1), RORC(1), THRA(2), THRB(1)	5945212	49	13	47	16	17	9	7	5	11	0	0.260	1.000	1.000
496	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(1), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(4), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	7928447	76	21	68	21	18	15	16	7	20	0	0.288	1.000	1.000
497	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(1), AKT3(1), CASP8(2), CCL3(1), CD14(2), CD40(1), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(1), LBP(1), LY96(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K7(9), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(2), TLR3(2), TLR4(1), TLR5(2), TLR6(3), TLR7(1), TLR8(1), TLR9(5), TOLLIP(1)	12462580	103	32	95	27	22	18	19	14	30	0	0.126	1.000	1.000
498	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(2), ACVR2A(7), AMH(1), AMHR2(5), BMP2(2), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CCR9(1), CD40(1), CSF1(2), CSF1R(4), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CL1(1), CXCL16(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPO(1), EPOR(2), FAS(2), FASLG(1), FLT1(3), FLT3(3), FLT4(9), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1R2(4), IL1RAP(2), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(1), INHBC(1), KDR(1), KIT(4), LEPR(5), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(2), PDGFC(2), PDGFRA(3), PDGFRB(4), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(3), RELT(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(7), TNFSF12(1), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TNFSF9(19), TPO(4), TSLP(1), VEGFB(1), XCR1(2)	24702730	275	72	224	44	63	51	35	40	85	1	3.71e-06	1.000	1.000
499	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), DLG4(1), LPA(5), MAP2K4(2), MAP3K1(3), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1), PTK2(4), RDX(3), ROCK1(3), ROCK2(1), SRF(1), TBXA2R(2)	6822191	50	13	50	14	8	8	13	10	11	0	0.477	1.000	1.000
500	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(2), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1)	6285969	52	19	48	14	13	7	9	5	18	0	0.423	1.000	1.000
501	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1)	1591340	9	1	9	1	2	2	3	0	2	0	0.256	1.000	1.000
502	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CAPNS2(1), CRKL(2), CSK(1), FYN(8), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(4), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SOS1(12), SRC(2), TLN1(9), VCL(1), ZYX(1)	6610962	76	28	57	12	18	15	7	6	30	0	0.0293	1.000	1.000
503	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	164	ADORA1(1), ADORA2A(1), ADORA3(4), ADRA1A(2), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CCR9(1), CHML(3), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(2), GPR50(1), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LHCGR(1), LTB4R(4), MC3R(3), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPY1R(2), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), RRH(1), SSTR1(4), SSTR4(3), SUCNR1(1), TBXA2R(2), TRHR(1)	17011496	172	43	158	41	48	22	48	29	24	1	0.00374	1.000	1.000
504	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NR1I3(1), PAK1(7), PDE3A(8), PDE3B(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1), VASP(1)	6797469	59	26	48	17	12	9	9	4	25	0	0.576	1.000	1.000
505	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(2), CHAT(3), CPT1B(4), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(6), PPAP2B(2)	7038470	60	13	60	17	21	7	13	9	10	0	0.200	1.000	1.000
506	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(2), PTPRU(6), REG1A(1), STAT1(1)	1574697	12	4	11	6	6	0	3	1	2	0	0.797	1.000	1.000
507	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(1), BCKDHB(1), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	4962374	32	5	32	4	7	10	7	3	5	0	0.0173	1.000	1.000
508	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(4), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PAK1(7), PLCG1(1), PLCG2(6), PTPRZ1(3), RELA(1), SRC(2), TCIRG1(1), TJP1(4)	9749002	75	20	68	16	11	16	17	13	18	0	0.102	1.000	1.000
509	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CPT1B(4), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3)	6735400	52	5	52	12	17	16	8	5	6	0	0.0296	1.000	1.000
510	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), TRAF2(1), TRAF5(1)	4810431	30	8	30	10	6	8	5	5	6	0	0.298	1.000	1.000
511	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(3), CD1C(1), CD1D(6), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(1), CD3E(1), CD4(2), CD44(3), CD5(2), CD55(1), CD59(2), CR1(3), CR2(8), CSF1(2), CSF1R(4), CSF2RA(1), CSF3R(2), DNTT(3), EPO(1), EPOR(2), FCGR1A(1), FLT3(3), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL1R2(4), IL2RA(1), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(2), THPO(1), TPO(4)	11303688	113	34	103	27	23	20	18	25	27	0	0.0965	1.000	1.000
512	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(2), EGFR(2), HGS(2)	1766551	9	1	9	0	0	4	2	2	1	0	0.0535	1.000	1.000
513	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(2), AKT2(1), AKT3(1), BCL2L1(7), CBL(4), CBLB(1), CCND2(2), CCND3(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(4), EPO(1), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(5), LIF(2), LIFR(5), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(2), PIAS4(3), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRL(4), PRLR(3), PTPN6(4), SOCS4(2), SOCS5(2), SOCS7(1), SOS1(12), SOS2(1), SPRED1(1), SPRED2(1), SPRY4(3), STAM(5), STAM2(1), STAT1(1), STAT2(1), STAT3(2), STAT5A(1), STAT6(4), TPO(4), TSLP(1), TYK2(2)	20114610	191	59	158	45	45	31	22	30	63	0	0.0667	1.000	1.000
514	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(7), ACTN1(1), AKT1(2), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(3), BCAR1(2), BRAF(3), CDC42(1), CDKN2A(22), CRK(1), CSE1L(2), DOCK1(2), EPHB2(3), FYN(8), GRB7(5), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGB3BP(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(6), PTEN(2), PTK2(4), ROCK1(3), ROCK2(1), SHC1(1), SOS1(12), SOS2(1), SRC(2), TERF2IP(1), TLN1(9), TLN2(7), VASP(1), ZYX(1)	17125676	185	54	149	40	35	32	23	24	71	0	0.0447	1.000	1.000
515	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(1), CR2(8), CSK(1), DAG1(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(5), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPRC(2), SHC1(1), SOS1(12), SOS2(1), SYK(2), VAV1(4)	10278517	103	35	87	21	23	20	11	13	35	1	0.0340	1.000	1.000
516	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), ASH2L(2), CARM1(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(4), EZH2(3), FBXO11(1), HCFC1(3), HSF4(1), KDM6A(3), MEN1(3), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(4), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SATB1(10), SETD1A(17), SETD2(6), SETD8(1), SETDB1(2), STK38(2), SUV39H2(2), SUV420H1(3), SUV420H2(2), SUZ12(1), WHSC1(1), WHSC1L1(5)	16685783	106	45	78	23	10	13	18	17	48	0	0.500	1.000	1.000
517	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(1), STAT2(1), TYK2(2)	1725787	14	5	13	6	8	0	4	1	1	0	0.670	1.000	1.000
518	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1)	1840976	12	2	12	7	3	4	4	0	1	0	0.838	1.000	1.000
519	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(1), POLG(4), RRM1(1)	1787566	14	3	14	3	3	6	1	1	3	0	0.126	1.000	1.000
520	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(1), AKT1(2), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(2), EDN1(3), ELSPBP1(2), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MYH2(3), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	7037646	61	16	59	15	19	11	10	7	14	0	0.0760	1.000	1.000
521	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), AFMID(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(3), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2)	8366147	66	12	65	13	23	11	18	7	7	0	0.0207	1.000	1.000
522	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(3), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CRADD(2), DAXX(4), DFFB(1), GSN(6), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(4), PAK2(3), PRKCD(7), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(4), RASA1(1), RB1(3), RELA(1), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	9654596	81	23	72	20	14	10	20	11	26	0	0.269	1.000	1.000
523	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AK3(1), CAD(5), CTPS2(1), DPYD(3), DPYS(9), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), NME1(1), NME4(1), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2)	11254964	81	22	73	24	18	13	15	19	16	0	0.368	1.000	1.000
524	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB2(1), JAK2(2), TYK2(2)	2048364	11	3	11	4	2	1	2	3	3	0	0.697	1.000	1.000
525	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1)	2025420	10	1	10	2	1	1	4	1	3	0	0.459	1.000	1.000
526	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(4), ABCA10(3), ABCA12(12), ABCA13(9), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(5), ABCA8(6), ABCA9(7), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(4), ABCB5(6), ABCB6(2), ABCC10(3), ABCC11(2), ABCC12(3), ABCC2(15), ABCC3(4), ABCC4(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(2), ABCD1(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(4), TAP1(1), TAP2(1)	16443359	146	33	132	35	27	30	20	32	33	4	0.0271	1.000	1.000
527	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(5), CTPS2(1), DPYD(3), DPYS(9), DUT(1), NME1(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), RRM1(1), TYMS(1), UMPS(2), UPB1(2)	8020338	61	14	56	16	17	14	11	7	12	0	0.117	1.000	1.000
528	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BAD(1), CABIN1(4), CAMK4(2), CD3E(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR2(3), EGR3(1), EP300(4), FCER1A(1), FOSL1(1), GATA3(2), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(2), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(7), PPP3CC(2), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4)	12695825	114	37	88	25	26	20	12	9	46	1	0.127	1.000	1.000
529	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1)	2142667	7	2	7	3	1	2	3	1	0	0	0.799	1.000	1.000
530	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), EHHADH(1), HADHA(1), SCP2(1)	2317433	10	1	10	0	4	3	2	0	1	0	0.0319	1.000	1.000
531	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CITED2(1), CPT1B(4), CREBBP(2), DUT(1), EHHADH(1), EP300(4), HSD17B4(3), LPL(2), ME1(2), NCOR1(7), NCOR2(4), NFKBIA(2), NR1H3(3), NRIP1(1), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTGS2(1), RB1(3), RELA(1), SP1(1), STAT5A(1)	8802872	56	12	56	18	15	15	10	8	8	0	0.221	1.000	1.000
532	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2)	2326713	18	2	18	2	6	4	4	1	3	0	0.0546	1.000	1.000
533	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1)	2519690	12	2	12	5	0	4	5	2	1	0	0.801	1.000	1.000
534	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), ETV5(1), IL12B(1), IL12RB2(1), JAK2(2), MAP2K6(2), MAPK8(2), TYK2(2)	2590830	12	3	12	4	3	1	2	2	4	0	0.511	1.000	1.000
535	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ENPP3(2), ENTPD2(2), FHIT(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NPR1(2), NPR2(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(3), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(5), PKLR(2), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1)	17892163	136	25	136	30	48	33	23	13	17	2	0.000946	1.000	1.000
536	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(1), AKT3(1), ARRB1(1), ARRB2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(1), CACNG3(2), CACNG5(4), CD14(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP16(1), DUSP6(2), DUSP7(1), ECSIT(6), EGF(2), EGFR(2), FAS(2), FASLG(1), FGF10(14), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FLNA(8), FLNB(3), FLNC(9), HRAS(1), IKBKB(2), IL1B(1), IL1R2(4), JUND(1), KRAS(66), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MOS(1), MRAS(2), NF1(2), NFATC2(5), NFATC4(4), NFKB2(1), NLK(1), NR4A1(3), NTF3(6), NTRK1(2), NTRK2(3), PAK1(7), PAK2(3), PDGFRA(3), PDGFRB(4), PLA2G3(2), PLA2G6(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTPN5(1), PTPN7(1), RAC2(1), RAP1B(2), RAPGEF2(4), RASA1(1), RASA2(1), RASGRF2(4), RASGRP1(2), RASGRP2(1), RASGRP3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS1(12), SOS2(1), SRF(1), STK4(2), STMN1(1), TAOK1(2), TAOK2(23), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TNFRSF1A(2), TP53(59), TRAF2(1)	40646147	513	86	363	103	113	85	85	65	160	5	1.47e-05	1.000	1.000
537	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(5), APC2(2), ARAF(2), ARHGEF1(4), ARHGEF12(4), ARHGEF6(1), ARHGEF7(3), ARPC1A(1), ARPC2(1), ARPC3(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BRAF(3), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(4), DIAPH2(1), DIAPH3(15), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF10(14), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FN1(8), GIT1(4), GSN(6), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KRAS(66), LIMK1(1), LIMK2(2), MOS(1), MRAS(2), MYH10(24), MYH14(4), MYH9(2), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(4), PTK2(4), PXN(1), RAC2(1), RDX(3), RHOA(1), ROCK1(3), ROCK2(1), SCIN(1), SOS1(12), SOS2(1), SSH1(3), SSH2(1), SSH3(1), TIAM1(6), TIAM2(1), VAV1(4), VCL(1), WASF1(1), WASF2(2), WASL(5)	38826006	420	86	286	98	74	85	81	44	134	2	0.0102	1.000	1.000
538	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GLCE(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(3), NDST4(2)	2925902	30	6	30	7	12	4	9	3	2	0	0.128	1.000	1.000
539	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(2), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	3128781	16	5	16	6	4	3	5	2	2	0	0.628	1.000	1.000
540	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(2), CHAT(3), CHPT1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(8), ETNK2(1), GPAM(3), GPD1(1), GPD2(1), LYPLA2(1), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2), PTDSS1(2), PTDSS2(1), SH3GLB1(1)	9209282	68	22	61	23	21	7	12	10	18	0	0.581	1.000	1.000
541	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	238	ADORA1(1), ADORA2A(1), ADORA3(4), ADRA1A(2), ADRA2A(1), ADRA2B(4), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CCKAR(6), CCKBR(3), CGA(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHB(1), FSHR(2), GABBR1(11), GABBR2(1), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GABRB1(3), GABRB2(2), GABRB3(3), GABRD(5), GABRE(2), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(1), GLRA2(3), GLRB(1), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(3), GRIA4(1), GRID1(6), GRID2(4), GRIK1(1), GRIK2(4), GRIK3(3), GRIK4(1), GRIK5(1), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRIN3A(4), GRIN3B(2), GRM1(13), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM6(6), GRM7(5), GRM8(3), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LEPR(5), LHB(1), LHCGR(1), LTB4R(4), LTB4R2(1), MC2R(2), MC3R(3), MC5R(2), MCHR1(1), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR2(1), NPY1R(2), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PRL(4), PRLR(3), PRSS1(3), PTGDR(2), PTGER3(1), PTGFR(1), RXFP1(1), SSTR1(4), SSTR4(3), SSTR5(4), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), THRA(2), THRB(1), TRHR(1), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	31017226	361	60	336	90	107	56	75	53	69	1	9.99e-05	1.000	1.000
542	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), CLK3(3), CLK4(1), COL2A1(4), CPSF1(3), CPSF2(4), CPSF3(3), CPSF4(1), CSTF1(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(3), DHX16(4), DHX38(1), DHX8(1), DHX9(10), DICER1(7), FUS(2), METTL3(1), NCBP2(1), NONO(1), PABPN1(2), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(3), PRPF8(4), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B1(1), SF3B2(1), SF3B5(1), SNRPB(1), SNRPE(2), SNRPN(3), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF1(3), U2AF2(2), XRN2(3)	14643566	103	36	91	27	27	14	14	17	30	1	0.355	1.000	1.000
543	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(1), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(3), CAPN5(2), CAPN6(2), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), FYN(8), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), MAP2K6(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(4), PXN(1), RAC2(1), RAP1B(2), ROCK1(3), ROCK2(1), SDCCAG8(1), SEPP1(1), SHC1(1), SORBS1(1), SOS1(12), SRC(2), TLN1(9), TNS1(4), VASP(1), VCL(1), ZYX(1)	18803029	154	42	130	41	31	32	29	15	47	0	0.139	1.000	1.000
544	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(3), CCND2(2), CCND3(1), CDC42(1), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), CRK(1), CRKL(2), CTNNB1(8), DIAPH1(4), DOCK1(2), EGF(2), EGFR(2), ERBB2(6), FARP2(1), FLNA(8), FLNB(3), FLNC(9), FLT1(3), FN1(8), FYN(8), GSK3B(1), HRAS(1), IBSP(2), IGF1R(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KDR(1), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYLK(8), MYLK2(3), MYLPF(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RELN(7), RHOA(1), ROCK1(3), ROCK2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SRC(2), THBS1(3), THBS2(4), THBS4(21), TLN1(9), TLN2(7), TNC(10), TNN(2), TNR(9), TNXB(8), VASP(1), VAV1(4), VCL(1), VEGFB(1), VTN(2), VWF(5), ZYX(1)	51787173	487	81	432	124	124	91	78	67	122	5	0.00270	1.000	1.000
545	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	CHAD(1), COL11A1(5), COL11A2(3), COL17A1(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), DES(1), DSC1(4), DSC2(5), DSC3(5), DSG1(2), DSG2(2), DSG4(5), FN1(8), GJA3(1), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(1), GJC2(2), GJC3(2), GJD4(2), IBSP(2), INA(3), ITGB4(7), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT15(4), KRT16(1), KRT19(1), KRT2(3), KRT20(2), KRT27(1), KRT28(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(2), KRT7(3), KRT73(10), KRT74(2), KRT75(1), KRT76(4), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(6), PRPH(1), RELN(7), THBS1(3), THBS2(4), THBS4(21), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5)	34817327	361	75	325	97	104	55	60	49	89	4	0.0252	1.000	1.000
546	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD44(3), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), DAG1(2), FN1(8), FNDC1(6), FNDC3A(1), GP5(2), GP6(2), GP9(2), HMMR(6), HSPG2(2), IBSP(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), RELN(7), SDC3(1), SDC4(2), SV2A(4), SV2C(1), THBS1(3), THBS2(4), THBS4(21), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5)	31473748	299	65	266	81	75	52	55	41	72	4	0.0623	1.000	1.000
547	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY7(3), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(2), ATP2A1(3), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B3(6), ATP2B4(1), AVPR1B(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(6), CCKBR(3), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GNA11(2), GNA14(1), GNA15(2), GNAQ(1), GNAS(13), GRIN1(7), GRIN2A(6), GRIN2C(5), GRIN2D(5), GRM1(13), GRM5(7), GRPR(1), HRH2(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), LHCGR(1), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), P2RX2(1), P2RX7(1), PDE1B(1), PDGFRA(3), PDGFRB(4), PHKA2(2), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(18), RYR2(10), RYR3(17), SLC25A4(1), SLC8A1(1), SLC8A2(3), SLC8A3(2), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(3)	38157707	408	61	372	118	128	58	79	58	81	4	0.0122	1.000	1.000
548	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADRA1A(2), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B3(6), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1S(4), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(1), PLCB3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SLC8A3(2), YWHAH(1)	26370353	256	54	230	87	84	40	41	28	59	4	0.287	1.000	1.000
549	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2A(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX55(19), DDX56(2), DHX58(2), ENPP3(2), EP400(7), ERCC2(1), ERCC3(8), G6PC2(1), GAA(2), GANC(1), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), IFIH1(4), MGAM(1), MOV10L1(5), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGM(1), RAD54L(3), RUVBL2(3), SETX(5), SI(3), SKIV2L2(1), SMARCA2(8), TREH(1), UGDH(1), UGP2(5), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), UXS1(1)	17121387	149	53	116	47	26	25	20	18	59	1	0.870	1.000	1.000
550	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(4), CDH2(4), CDH3(9), CDH4(3), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(4), CNTN2(1), CNTNAP1(1), CNTNAP2(7), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(2), NFASC(3), NLGN1(4), NLGN2(2), NLGN3(5), NRCAM(1), NRXN1(2), NRXN2(5), NRXN3(4), PDCD1(1), PTPRC(2), PTPRF(20), PTPRM(6), PVRL1(13), PVRL2(11), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELP(3), SIGLEC1(9), VCAN(10)	20604902	217	52	176	63	54	36	34	23	70	0	0.156	1.000	1.000
551	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(2), ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF4(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(3), DGKZ(3), ETS2(2), GABPA(2), GBA2(2), GNAQ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(1), ITPR1(6), ITPR2(9), ITPR3(8), MAFF(2), MIB1(1), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), PDE4D(3), PLCB3(4), PLCG1(1), PLCG2(6), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCH(5), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SP1(1), TNXB(8), YWHAH(1)	24325259	218	49	203	70	69	32	40	27	48	2	0.185	1.000	1.000
552	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX55(19), DDX56(2), DHFR(1), DHX58(2), EP400(7), ERCC2(1), ERCC3(8), FPGS(3), GCH1(1), GGH(1), IFIH1(4), MOV10L1(5), NUDT8(1), QDPR(2), RAD54L(3), RUVBL2(3), SETX(5), SKIV2L2(1), SMARCA2(8)	8745606	110	41	79	30	17	18	10	14	50	1	0.704	1.000	1.000
553	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(2), CALML6(1), CDIPT(2), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPP5D(1), INPP5E(1), INPPL1(5), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PRKCG(2), PTEN(2), SYNJ2(2)	17462490	143	39	133	40	43	22	18	22	38	0	0.0987	1.000	1.000
554	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(3), BUB1(1), CDIPT(2), CDKL1(1), CLK1(3), CLK2(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(3), MOS(1), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), PRKD1(2), PRKG1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), STK11(2), TGFBR1(5)	15866014	133	38	123	37	48	18	13	20	34	0	0.158	1.000	1.000
555	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ENPP3(2), ENTPD2(2), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GMPR(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NME4(1), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT2(1), NUDT9(3), PAICS(2), PAPSS1(3), PAPSS2(3), PDE10A(6), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(1), PFAS(5), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(6)	22738846	169	36	165	43	54	31	27	33	22	2	0.0143	1.000	1.000
556	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(7), MYBPC1(5), MYBPC3(3), MYH3(1), MYH6(6), MYH7(6), MYH8(4), MYL1(1), MYL3(1), MYOM1(3), NEB(14), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(3), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(88)	18946046	164	34	162	48	41	41	37	23	20	2	0.265	1.000	1.000
557	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(3), CHUK(1), CREB1(2), DAXX(4), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP3K9(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(2), MEF2D(1), NFKBIA(2), PAK1(7), PAK2(3), RELA(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), RPS6KB2(2), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TRADD(1), TRAF2(1)	13515549	106	33	90	36	23	19	19	7	38	0	0.807	1.000	1.000
558	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(10), B4GALT5(2), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHST2(2), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), DPAGT1(5), EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), XYLT1(4), XYLT2(4)	15537002	124	32	109	35	36	17	26	16	29	0	0.210	1.000	1.000
559	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(9), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADIPOR1(2), AKT1(2), AKT2(1), AKT3(1), CAMKK1(1), CHUK(1), CPT1B(4), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS1(15), IRS2(3), IRS4(3), JAK1(1), JAK2(2), JAK3(3), LEPR(5), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(3), PCK2(4), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(3), PRKCQ(2), RELA(1), SLC2A1(4), STAT3(2), STK11(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2)	11653257	113	30	100	34	28	20	16	13	35	1	0.258	1.000	1.000
560	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(1), CSNK1G3(7), DHH(2), FBXW11(1), GLI1(5), GLI2(2), GLI3(8), GSK3B(1), HHIP(4), LRP2(3), PRKACG(2), PTCH1(4), PTCH2(6), SMO(2), STK36(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2), ZIC2(4)	8586477	85	28	78	30	31	15	14	6	19	0	0.489	1.000	1.000
561	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(2), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(4), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(3), RAPGEF4(3), RASSF5(1), RHOA(1), RHOH(1), ROCK1(3), ROCK2(1), SIPA1(4), THY1(1), VASP(1), VAV1(4), VCL(1)	17399019	135	28	134	47	46	29	15	21	22	2	0.218	1.000	1.000
562	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(1), INPP4B(1), INPP5A(1), INPP5E(1), INPPL1(5), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PTEN(2), SYNJ2(2)	10374069	75	26	70	27	15	13	11	14	22	0	0.603	1.000	1.000
563	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(13), CARS2(2), DARS(1), DARS2(1), EARS2(1), EPRS(1), FARS2(2), FARSB(1), GARS(5), HARS2(1), IARS(4), KARS(2), LARS2(2), MTFMT(3), NARS2(2), PARS2(1), QARS(1), RARS(1), RARS2(3), TARS(2), VARS(2), VARS2(2), WARS(2)	7458004	56	25	46	17	12	8	11	7	18	0	0.709	1.000	1.000
564	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(2), DAXX(4), HRAS(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAP3K9(2), MAPKAPK5(1), MEF2A(2), MEF2D(1), RPS6KA5(1), SHC1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TRADD(1), TRAF2(1)	5122030	43	22	33	15	11	2	8	4	18	0	0.883	1.000	1.000
565	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), APH1A(2), CREBBP(2), CTBP2(5), DLL4(1), DTX1(3), DTX2(4), DTX4(1), DVL1(4), DVL2(3), EP300(4), JAG1(2), JAG2(3), LFNG(1), MAML1(2), MAML2(3), MAML3(13), NCOR2(4), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RFNG(1), SNW1(1)	9997723	90	21	79	44	26	21	15	9	19	0	0.917	1.000	1.000
566	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(3), CREB1(2), DUSP6(2), MOS(1), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1)	4123510	27	21	18	12	5	2	2	1	17	0	0.993	1.000	1.000
567	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP4F2(2), CYP4F3(3), EPX(4), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX5(1), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4)	3886097	46	19	40	18	18	3	8	2	14	1	0.824	1.000	1.000
568	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(8), GTF2E1(1), GTF2E2(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3B(3), POLR3E(3), TAF5(1), TAF6(1), TBP(3)	4808651	38	18	30	12	9	5	7	3	14	0	0.750	1.000	1.000
569	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(1), CYP4F2(2), CYP4F3(3), DHRS4(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), LTA4H(1), PLA2G3(2), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	5432487	47	17	41	24	14	7	10	2	13	1	0.969	1.000	1.000
570	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(1), AKT3(1), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(1), RICTOR(5), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), STK11(2), TSC1(1), TSC2(6), ULK1(2), ULK3(1), VEGFB(1)	7464509	59	17	58	20	16	15	7	5	16	0	0.568	1.000	1.000
571	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2E1(1), GTF2F1(4), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(2), TBP(3)	3500081	28	17	21	17	4	3	4	1	15	1	0.999	1.000	1.000
572	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(2), ENPP3(2), GAA(2), GANAB(2), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), MGAM(1), PGM1(2), PGM3(1), PYGB(2), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1), UXS1(1)	7862722	51	17	49	18	15	11	10	5	10	0	0.561	1.000	1.000
573	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(1), CDC42(1), CREB1(2), DUSP10(1), MAP2K4(2), MAP2K6(2), MAP3K10(3), MAP3K4(2), MAP3K7(9), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1), SRF(1)	4720025	31	16	24	13	6	3	4	3	15	0	0.928	1.000	1.000
574	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(3), SHC1(1), SOS1(12), SRF(1), STAT3(2)	3349604	29	15	20	13	5	3	3	3	15	0	0.976	1.000	1.000
575	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), B3GALT4(1), CDR1(1), DGKI(2), FAU(1), IL6ST(3), RPL10(3), RPL11(1), RPL18(2), RPL18A(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL3L(2), RPL4(3), RPL7A(1), RPLP0(1), RPLP2(1), RPS11(2), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1)	7289271	50	14	48	28	12	7	10	6	15	0	0.997	1.000	1.000
576	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), FPR1(1), GNA15(2), GNB1(2), HRAS(1), MAP2K6(2), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PAK1(7), PLCB1(1), PPP3CA(1), PPP3CC(2), RELA(1)	5346036	44	13	37	16	8	8	10	5	13	0	0.811	1.000	1.000
577	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), DAO(2), DMGDH(3), GARS(5), GLDC(1), HSD3B7(3), PHGDH(1), PSAT1(4), RDH11(2), SARDH(2), SHMT1(1), SHMT2(2), TARS(2)	5989642	40	13	38	16	18	10	5	5	1	1	0.428	1.000	1.000
578	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), DRD1(2), DRD3(1), DRD5(2), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1)	3620486	37	13	36	15	11	8	9	6	3	0	0.561	1.000	1.000
579	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), CPT1B(4), DAO(2), DMGDH(3), GARS(5), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(6), SARDH(2), SHMT1(1), SHMT2(2), TARS(2)	5892341	45	11	44	17	17	12	6	5	4	1	0.363	1.000	1.000
580	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHSY1(1), DSE(3), XYLT1(4), XYLT2(4)	2093780	20	11	18	12	8	2	5	1	4	0	0.884	1.000	1.000
581	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1)	4887718	30	10	30	14	10	5	4	2	9	0	0.759	1.000	1.000
582	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1)	2547691	28	9	24	11	5	6	3	4	10	0	0.686	1.000	1.000
583	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CD97(1), CRHR2(1), ELTD1(5), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(6), LPHN3(1), VIPR1(1), VIPR2(1)	3748711	31	9	31	13	6	6	4	10	5	0	0.593	1.000	1.000
584	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3)	3148313	33	9	29	13	7	8	5	3	10	0	0.596	1.000	1.000
585	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADHA(1), PLOD1(2), PLOD2(2), SHMT1(1), SHMT2(2)	5142488	32	9	29	15	10	5	11	1	4	1	0.791	1.000	1.000
586	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(5), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1)	3877189	32	9	29	13	7	6	5	4	10	0	0.806	1.000	1.000
587	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(5), IARS(4), KARS(2), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2)	4367632	24	8	23	9	7	4	7	5	1	0	0.644	1.000	1.000
588	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), HSD3B7(3), MTMR2(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(2), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1)	5205202	37	8	37	15	12	6	13	4	2	0	0.562	1.000	1.000
589	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(3), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1), UAP1(1)	3977329	28	8	28	13	10	3	8	3	4	0	0.827	1.000	1.000
590	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2)	2891470	20	8	20	11	5	5	2	2	6	0	0.838	1.000	1.000
591	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(1), C6(6), C7(4), ICAM1(2), IL6(1), ITGAL(3), ITGB2(1), SELP(3)	3394873	27	8	27	11	8	7	5	2	5	0	0.547	1.000	1.000
592	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4)	962323	13	7	11	11	4	4	2	0	3	0	0.941	1.000	1.000
593	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), RELA(1)	3878270	23	7	23	11	5	8	3	3	4	0	0.700	1.000	1.000
594	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4)	962323	13	7	11	11	4	4	2	0	3	0	0.941	1.000	1.000
595	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(1), SRC(2), STAT3(2)	2135891	21	7	20	12	8	6	4	0	3	0	0.831	1.000	1.000
596	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), DNMT3A(5), DNMT3B(2), MTFMT(3), MTR(1), TAT(1)	2870011	15	6	13	14	4	2	3	2	4	0	0.999	1.000	1.000
597	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(1), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PAPSS1(3), PAPSS2(3), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SCLY(2)	3452640	26	6	26	11	6	6	9	2	3	0	0.655	1.000	1.000
598	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(6), REG1A(1), SOAT1(1)	1925859	17	6	16	11	8	3	4	0	2	0	0.911	1.000	1.000
599	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(2), PMM2(1), TPI1(2)	3330512	24	5	24	11	9	4	8	1	2	0	0.611	1.000	1.000
600	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2)	3217607	27	5	27	12	9	4	6	4	4	0	0.799	1.000	1.000
601	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1), PNPO(1), PSAT1(4)	668920	6	5	5	4	3	1	2	0	0	0	0.816	1.000	1.000
602	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1)	724490	8	4	8	5	6	1	0	1	0	0	0.877	1.000	1.000
603	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP25(1), SNAP29(3), STX11(1), STX12(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VTI1A(1)	2332365	14	4	14	10	8	0	1	2	3	0	0.939	1.000	1.000
604	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(3), PDHA1(1), SLC18A3(2)	985290	9	3	9	7	4	0	4	1	0	0	0.929	1.000	1.000
605	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1), SLC25A11(1)	1282632	9	3	9	5	4	4	0	1	0	0	0.678	1.000	1.000
606	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(5), DNMT3B(2), MTR(1)	2403812	10	3	10	12	4	1	3	2	0	0	0.998	1.000	1.000
607	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(1), RB1(3), SKP2(2)	1187640	11	3	11	5	2	3	3	3	0	0	0.775	1.000	1.000
608	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1), IL6(1), IL9(1)	1360609	4	2	4	3	0	2	1	1	0	0	0.838	1.000	1.000
609	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), NOX1(2), RELA(1), XDH(6)	1378242	10	2	10	6	2	3	3	2	0	0	0.886	1.000	1.000
610	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(1), RB1(3), SKP2(2)	1183936	7	2	7	4	1	1	2	3	0	0	0.907	1.000	1.000
611	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(1), MTNR1B(1), PTGDR(2), PTGFR(1), TBXA2R(2)	1607912	7	2	7	5	2	2	3	0	0	0	0.834	1.000	1.000
612	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), SQLE(1)	591668	3	1	3	3	1	1	1	0	0	0	0.922	1.000	1.000
613	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	927392	2	1	2	3	1	1	0	0	0	0	0.942	1.000	1.000
614	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1), UXS1(1)	534709	2	1	2	2	0	0	1	1	0	0	0.978	1.000	1.000
615	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), SQLE(1)	444961	3	1	3	3	1	1	1	0	0	0	0.921	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		68977	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
