rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	207846	2	2	2	0	0	0	1	0	1	0	0.885	0.0657	1.000
2	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(5)	1669817	17	10	16	3	2	6	1	3	5	0	0.249	0.0795	1.000
3	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), SNX13(5), SRC(2), TERF2IP(1)	1553443	18	9	18	2	3	2	2	4	7	0	0.189	0.0871	1.000
4	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(1), RAB3A(1), RAB4A(1), RAB6A(1), RAB9A(1)	584670	10	4	10	1	5	2	2	1	0	0	0.100	0.166	1.000
5	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IL12B(1)	410351	5	5	4	2	0	2	0	0	3	0	0.927	0.184	1.000
6	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(4), PIK3R1(1), PTK2(4), SRC(2), TERT(6), YWHAH(1)	2309601	27	13	27	4	3	7	2	5	10	0	0.0545	0.192	1.000
7	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), WASF1(1), WASL(5)	1110886	14	9	13	4	2	5	2	2	3	0	0.538	0.209	1.000
8	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	CYP11A1(2), CYP11B1(5), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	1180949	12	8	11	4	4	2	2	2	2	0	0.591	0.289	1.000
9	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	CYP11A1(2), CYP11B1(5), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	1180949	12	8	11	4	4	2	2	2	2	0	0.591	0.289	1.000
10	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), SNAP25(1)	443254	4	3	4	1	4	0	0	0	0	0	0.520	0.311	1.000
11	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(2), CES1(1), ESD(1)	826594	9	4	8	1	4	3	2	0	0	0	0.122	0.387	1.000
12	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(9), CDC25C(2), YWHAH(1)	2068738	20	11	19	5	2	2	4	4	8	0	0.725	0.406	1.000
13	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(2), HRAS(1), SHC1(1), SRC(2)	847099	6	5	6	2	2	2	0	0	2	0	0.559	0.425	1.000
14	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	9	CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(2), PPP2CA(1)	1018017	11	5	11	1	4	3	0	2	2	0	0.0942	0.440	1.000
15	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	156442	1	1	1	0	0	0	0	0	1	0	0.842	0.458	1.000
16	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(8), CDC25C(2), MYT1(10), YWHAH(1)	1761405	21	8	20	5	3	4	3	5	6	0	0.416	0.459	1.000
17	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	8	CDC25C(2), CSK(1), SRC(2)	1138665	5	5	4	1	1	2	0	0	2	0	0.503	0.472	1.000
18	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3)	909411	7	4	7	0	4	0	1	0	2	0	0.150	0.473	1.000
19	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	14	CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR2(5)	1240827	10	6	9	3	4	0	0	2	4	0	0.670	0.474	1.000
20	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F5(5), FGA(5), FGB(4), FGG(2), PROC(1), PROS1(1), SERPINC1(2), TFPI(3)	2249498	27	9	25	5	3	6	11	5	2	0	0.191	0.475	1.000
21	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(3), CASP1(4), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(7), RERE(9), WWP1(2), WWP2(3)	3324903	42	19	37	9	11	8	3	5	15	0	0.195	0.509	1.000
22	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(5), AXIN1(5), CD14(2), CTNNB1(8), DVL1(4), FZD1(5), GNAI1(1), GSK3B(1), LBP(1), LEF1(3), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1), TOLLIP(1), WNT1(1)	4297741	48	16	47	5	14	9	5	12	8	0	0.00292	0.510	1.000
23	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4)	1762032	13	6	13	1	2	4	0	3	3	1	0.0591	0.511	1.000
24	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRB1(1)	325957	3	2	3	1	0	0	0	1	2	0	0.905	0.514	1.000
25	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(1), AGT(1), AGTR2(1), CMA1(1), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4)	3390137	30	13	28	2	4	4	11	2	8	1	0.0504	0.526	1.000
26	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(8), BMPR1A(3), BMPR2(3)	858608	14	5	14	3	2	6	2	1	3	0	0.337	0.543	1.000
27	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(5), GLS(2), GOT1(2)	1072483	11	3	11	0	2	2	2	3	1	1	0.0398	0.556	1.000
28	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), HADHB(2), HSD17B4(3), PPT1(1), PPT2(2)	1170613	10	4	10	0	2	3	1	2	2	0	0.0548	0.557	1.000
29	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	6	ADORA1(1), ADORA2A(1), P2RY1(2), P2RY2(1), P2RY6(1)	586800	6	3	6	1	3	1	2	0	0	0	0.240	0.560	1.000
30	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), NCK1(3), NCKAP1(4), NTRK1(2), PIR(1), WASF1(1), WASF2(2), WASL(5)	1962570	25	10	24	4	7	7	3	4	4	0	0.119	0.561	1.000
31	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	5	ARNTL(1), CRY1(1), CSNK1E(1), PER1(4)	965074	7	4	6	1	2	0	0	1	4	0	0.484	0.568	1.000
32	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	7	CPN2(2), CYP11A1(2), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1)	807775	9	5	9	3	2	2	3	2	0	0	0.505	0.578	1.000
33	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	10	ADCY1(4), CFTR(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1)	1521614	15	5	15	2	5	5	1	3	1	0	0.0645	0.579	1.000
34	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(1), B3GNT5(1), FUT1(1), FUT2(3), ST3GAL4(2)	993382	9	6	9	2	8	0	0	1	0	0	0.289	0.585	1.000
35	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	98584	2	1	2	1	2	0	0	0	0	0	0.803	0.596	1.000
36	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1)	1776356	13	9	13	3	4	3	1	2	3	0	0.298	0.608	1.000
37	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2)	1401634	14	5	14	1	9	2	2	0	1	0	0.0241	0.622	1.000
38	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	5	ADCY1(4), GNB1(2), PRKAR1A(1)	613073	7	3	7	1	2	3	0	1	1	0	0.203	0.627	1.000
39	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), YWHAH(1)	1962071	16	8	16	4	0	4	4	3	5	0	0.447	0.635	1.000
40	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(2), OAT(2), PRODH(1)	783236	9	3	9	1	2	1	2	1	3	0	0.214	0.643	1.000
41	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	HLA-DRB1(1)	316315	1	1	1	0	0	0	0	0	1	0	1.000	0.654	1.000
42	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(8), CDC25C(2), CDK4(2), MYT1(10), RB1(3), YWHAH(1)	2172878	26	8	25	5	4	4	6	6	6	0	0.288	0.655	1.000
43	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(2), ABCB4(4), ABCC3(4), GSTP1(1)	1969378	15	9	12	3	2	3	2	4	4	0	0.418	0.656	1.000
44	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1)	830758	11	3	11	2	1	2	1	4	3	0	0.375	0.662	1.000
45	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	224782	3	1	3	0	1	1	0	1	0	0	0.348	0.679	1.000
46	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(1), NFS1(1), PHPT1(1), TPK1(2)	881786	6	3	6	2	1	2	2	0	1	0	0.780	0.679	1.000
47	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(3), INPPL1(5), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2)	2721003	23	12	21	5	3	4	3	5	8	0	0.367	0.687	1.000
48	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	8	CYP17A1(1), F13B(1), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2), HSD3B2(1)	1019733	11	3	11	3	2	5	2	2	0	0	0.317	0.689	1.000
49	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), KEAP1(1), MAFF(2), MAPK8(2), NFE2L2(1)	1253790	8	4	8	0	2	0	0	3	3	0	0.115	0.689	1.000
50	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), F10(4), F12(2), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1)	6151124	59	20	53	8	7	11	21	5	14	1	0.0683	0.699	1.000
51	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	5	CSF1(2), IL1B(1), MST1R(5)	700546	8	5	7	3	0	3	0	1	4	0	0.633	0.702	1.000
52	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(1)	274454	1	1	1	0	1	0	0	0	0	0	0.782	0.703	1.000
53	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	5	BAAT(1), CSAD(1), GAD1(6), GAD2(5), GGT1(1)	743944	14	7	14	6	4	3	4	1	1	1	0.657	0.704	1.000
54	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD80(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1)	1747533	12	6	12	2	1	2	2	2	5	0	0.325	0.706	1.000
55	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	305620	2	1	2	1	0	0	0	1	1	0	0.765	0.708	1.000
56	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(3), FUT5(1), FUT6(1)	707432	6	3	6	1	5	1	0	0	0	0	0.233	0.726	1.000
57	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(2), CPOX(3), HMBS(1), PPOX(2)	1059298	8	6	8	2	2	2	1	1	2	0	0.626	0.726	1.000
58	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1)	2642202	23	11	23	3	5	6	3	2	7	0	0.0735	0.730	1.000
59	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2)	1027752	11	3	11	1	3	4	3	0	1	0	0.167	0.734	1.000
60	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1), HLA-DRB1(1)	544056	4	2	4	1	0	0	1	1	2	0	0.845	0.735	1.000
61	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFLAR(2)	529164	4	2	4	3	0	0	1	1	2	0	0.908	0.735	1.000
62	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	256508	1	1	1	0	0	0	0	1	0	0	0.796	0.738	1.000
63	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(3), GCNT2(2), ST8SIA1(2)	864472	8	3	8	1	5	2	1	0	0	0	0.123	0.745	1.000
64	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(2), TAT(1), TYR(3)	641413	7	2	7	3	1	1	3	2	0	0	0.814	0.746	1.000
65	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LPL(2)	727176	7	2	7	1	1	3	1	1	1	0	0.228	0.746	1.000
66	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	AKT1(2), GNB1(2), NOS3(6), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(1)	2100505	18	7	18	4	2	4	6	2	4	0	0.383	0.754	1.000
67	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(1), ACADL(1), ACADSB(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2)	3882215	35	12	34	3	13	8	8	4	1	1	0.00138	0.760	1.000
68	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(4), FSHB(1), FSHR(2), XPO1(1)	1017088	8	3	8	0	3	1	1	2	1	0	0.103	0.762	1.000
69	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2)	775721	13	4	12	2	5	2	3	0	3	0	0.134	0.777	1.000
70	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(6), TH(1), TPH1(2)	850064	9	3	9	4	2	0	3	1	2	1	0.744	0.778	1.000
71	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(2), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), SHC1(1)	2320009	20	10	20	4	4	5	5	2	4	0	0.162	0.781	1.000
72	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR39(3), GPR65(2), GPR75(1)	1354180	10	5	10	3	1	1	0	4	4	0	0.736	0.783	1.000
73	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3E(1), HLA-A(4), ICAM1(2), ITGAL(3), ITGB2(1)	1050170	11	4	11	2	4	0	1	1	5	0	0.339	0.785	1.000
74	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(2), EIF4A2(2), EIF4G1(7), EIF4G3(7), GHR(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2)	3349827	29	13	28	6	4	8	7	4	6	0	0.224	0.785	1.000
75	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(4), AKT1(2), ATM(8), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2)	2791090	23	9	23	5	1	2	6	8	6	0	0.407	0.787	1.000
76	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(4)	1181336	14	3	14	2	2	4	5	3	0	0	0.165	0.787	1.000
77	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(4), F12(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), LPA(5), PLAT(2), SERPINE1(2), SERPINF2(1), VWF(5)	4729919	43	15	39	8	10	8	15	4	6	0	0.0959	0.788	1.000
78	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CD4(2), HLA-DRB1(1), IL1B(1), IL6(1)	630304	5	2	5	1	0	0	1	1	3	0	0.715	0.791	1.000
79	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(3), ARHGAP5(3), CASP1(4), CASP10(2), CASP8(2), CASP9(1)	1616753	15	6	14	5	2	3	1	2	7	0	0.780	0.799	1.000
80	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(7), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1)	2625208	24	9	23	3	4	5	6	3	6	0	0.0607	0.801	1.000
81	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1)	1832313	14	7	14	3	4	3	1	3	3	0	0.245	0.805	1.000
82	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), EPO(1), IL6(1), IL7(1), IL9(1)	854176	8	2	8	1	0	1	2	4	1	0	0.388	0.812	1.000
83	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	HLA-A(4), KLRC3(2), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4)	2403055	21	9	21	5	5	3	3	5	4	1	0.325	0.821	1.000
84	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	16	CBL(4), EGF(2), EGFR(2), HRAS(1), PTPRB(10), RASA1(1), SHC1(1), SRC(2)	2978173	23	8	23	2	2	7	4	5	4	1	0.0401	0.822	1.000
85	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(1), CD4(2)	439716	3	1	3	1	0	0	0	1	2	0	0.839	0.823	1.000
86	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2)	1861052	11	5	10	4	1	2	1	3	4	0	0.782	0.825	1.000
87	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(7), ATM(8), BRCA1(5), MAPK8(2), MDM2(2), MRE11A(3), NFKBIA(2), RELA(1)	3746472	30	13	26	2	3	4	7	4	12	0	0.0592	0.828	1.000
88	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(4), ARHGEF1(4), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), ROCK1(3)	3127227	22	10	22	5	3	6	3	4	6	0	0.215	0.830	1.000
89	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(2), ERBB3(4), NRG1(5), UBE2D1(1)	1412586	14	4	14	1	3	2	4	2	3	0	0.110	0.830	1.000
90	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(2), EGFR(2), IGF1R(3), POLR2A(2), PPP2CA(1), RB1(3), TEP1(10), TERT(6), TNKS(3), XRCC5(2)	3674830	34	13	31	8	9	6	4	7	7	1	0.265	0.833	1.000
91	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD4(2), HLA-DRB1(1), LCK(1), PTPRC(2), ZAP70(5)	1088739	12	3	12	2	3	2	1	2	4	0	0.258	0.847	1.000
92	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), IL6(1)	860541	9	2	9	1	1	1	1	3	3	0	0.263	0.850	1.000
93	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(4), EGF(2), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(1), SRC(2)	2667516	23	9	21	2	4	6	3	3	7	0	0.0482	0.850	1.000
94	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	8	ADAR(2), APOBEC3B(2), APOBEC3G(1)	900759	5	2	5	1	3	2	0	0	0	0	0.359	0.857	1.000
95	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), SLC2A1(4)	3501189	30	12	28	5	5	5	9	2	8	1	0.260	0.857	1.000
96	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	572133	1	1	1	0	0	0	0	0	1	0	0.829	0.859	1.000
97	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(4)	1639934	22	5	22	6	9	3	5	1	3	1	0.226	0.860	1.000
98	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(3)	880183	6	2	6	1	1	0	3	1	1	0	0.435	0.862	1.000
99	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1)	2472306	22	6	22	2	7	3	7	3	1	1	0.0285	0.866	1.000
100	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(3), CASP9(1), DAXX(4), FAS(2), FASLG(1), MAPKAPK3(1)	1567330	16	7	14	5	3	4	3	2	4	0	0.598	0.868	1.000
101	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1)	1749661	11	5	9	0	1	3	0	1	6	0	0.0930	0.868	1.000
102	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1)	1721928	23	6	23	6	5	6	5	4	3	0	0.311	0.870	1.000
103	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1438872	6	3	6	1	2	0	2	1	1	0	0.402	0.871	1.000
104	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1438872	6	3	6	1	2	0	2	1	1	0	0.402	0.871	1.000
105	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(1)	937796	19	5	18	3	7	6	0	2	4	0	0.0316	0.873	1.000
106	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(8), CCNE1(1), CDK4(2), MDM2(2), RB1(3)	2390592	19	6	19	4	3	3	6	4	3	0	0.418	0.875	1.000
107	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(1), FLT3(3), IL6(1), IL9(1), TGFB1(1), TGFB2(2)	1162588	10	4	9	2	1	2	4	1	2	0	0.433	0.876	1.000
108	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(1), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2)	1240198	11	3	11	2	2	1	3	4	1	0	0.352	0.876	1.000
109	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPX1(1), PRKCE(1)	1090308	13	2	13	1	4	4	1	1	2	1	0.0342	0.877	1.000
110	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CDK4(2), MDM2(2), NXT1(1)	979264	6	2	6	1	3	0	3	0	0	0	0.387	0.883	1.000
111	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	23	ABAT(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2)	3498025	32	12	31	4	13	6	8	3	1	1	0.00848	0.883	1.000
112	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), CREB1(2), EDN1(3), EP300(4), EPO(1), HIF1A(1), NOS3(6)	2358032	20	6	19	2	4	2	5	2	7	0	0.123	0.889	1.000
113	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	8	CDC25C(2), CDK7(1), XPO1(1)	1072648	4	3	3	2	1	0	0	0	3	0	0.884	0.889	1.000
114	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	232415	1	1	1	1	0	0	1	0	0	0	0.968	0.890	1.000
115	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), AFMID(1), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1)	1833613	12	5	10	1	2	3	0	1	6	0	0.196	0.891	1.000
116	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(1), SHMT2(2)	590029	4	2	4	4	2	0	1	0	0	1	0.923	0.895	1.000
117	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(4), ESR1(1), SRC(2)	2080195	9	4	9	1	2	3	2	1	1	0	0.145	0.897	1.000
118	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNGR1(1), JAK1(1), JAK2(2), STAT1(1)	1031743	5	2	5	2	1	0	2	1	1	0	0.742	0.898	1.000
119	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(4), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(4), SPHK1(1), SRC(2)	3777430	31	10	31	2	5	11	3	5	7	0	0.00165	0.898	1.000
120	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(1), HRAS(1), INSR(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SRF(1)	2824761	16	8	16	3	5	2	0	4	5	0	0.221	0.900	1.000
121	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	11	F13A1(2), FGA(5), FGB(4), FGG(2), PLAT(2), SERPINE1(2)	1711876	17	5	16	6	3	3	4	4	3	0	0.629	0.901	1.000
122	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	6	AGT(1), AGTR2(1), KNG1(1), NOS3(6)	930079	9	3	9	2	3	0	5	0	1	0	0.483	0.905	1.000
123	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), PGM3(1), RENBP(1), UAP1(1)	2349416	20	7	20	6	8	3	5	1	3	0	0.353	0.906	1.000
124	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), OPRK1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1789927	11	4	11	2	5	1	3	0	2	0	0.294	0.906	1.000
125	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TAT(1), TPO(4)	3048453	36	11	35	8	17	5	7	3	4	0	0.0591	0.907	1.000
126	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(1), STAT3(2), STAT5A(1)	1675462	12	4	12	2	6	2	2	0	2	0	0.176	0.911	1.000
127	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNB1(2), HTR2C(1), PLCB1(1), TUB(2)	981132	7	3	7	2	0	4	0	2	1	0	0.416	0.913	1.000
128	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(2), TPO(4)	1603550	21	4	21	6	9	3	4	2	2	1	0.232	0.915	1.000
129	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2), KARS(2)	644905	4	2	4	3	1	0	1	1	1	0	0.952	0.917	1.000
130	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	3	RANBP1(1), RANGAP1(2)	270816	3	1	3	1	1	1	1	0	0	0	0.675	0.917	1.000
131	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(4), EPHA4(2), ITGA1(7), L1CAM(1), RAP1B(2), SELP(3)	1991355	19	6	19	2	6	5	2	2	4	0	0.0354	0.917	1.000
132	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS2(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	2070401	19	5	19	4	2	5	8	2	2	0	0.266	0.920	1.000
133	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(4), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1831499	18	4	18	2	5	6	1	2	4	0	0.0303	0.921	1.000
134	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(2), CHST12(1), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1)	1290043	14	6	14	3	3	2	2	4	3	0	0.346	0.923	1.000
135	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(2), MAP2K6(2), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1), SP1(1)	2691532	19	8	19	8	1	2	6	4	6	0	0.890	0.924	1.000
136	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(4), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1971277	19	6	19	5	7	3	6	2	1	0	0.340	0.924	1.000
137	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(4), ADCY1(4), CDC25C(2), GNAI1(1), GNB1(2), HRAS(1), MYT1(10), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), SRC(2)	2564405	34	11	33	6	11	10	4	5	4	0	0.0236	0.924	1.000
138	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(1)	630082	3	1	3	2	1	1	0	0	1	0	0.818	0.925	1.000
139	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), FARS2(2), GOT1(2), TAT(1)	1129552	8	4	7	2	0	2	3	2	1	0	0.580	0.929	1.000
140	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1)	2418149	29	8	29	8	6	6	6	6	5	0	0.315	0.930	1.000
141	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	10	ARRB1(1), GNB1(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1043243	9	2	9	1	5	3	1	0	0	0	0.0912	0.931	1.000
142	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	APC(5), AXIN1(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(8), DVL1(4), FZD1(5), GATA4(1), GSK3B(1), RFC1(4), TGFB1(1), TGFB2(2), TGFBR2(5), WNT1(1)	4786686	56	15	55	8	21	12	5	11	7	0	0.00432	0.933	1.000
143	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(4), AKT1(2), CAMK2D(1), CREB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), RPS6KA5(1)	3366640	24	10	24	5	7	4	2	3	8	0	0.222	0.935	1.000
144	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1)	3558924	27	9	27	5	7	7	7	4	1	1	0.0852	0.936	1.000
145	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	1216347	10	3	9	0	1	2	2	2	3	0	0.118	0.937	1.000
146	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(1), PFKL(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2)	1289033	15	3	15	4	5	6	1	2	1	0	0.170	0.937	1.000
147	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1), YWHAH(1)	1887910	14	7	14	5	4	3	0	3	4	0	0.580	0.938	1.000
148	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(2), CREBBP(2), EP300(4), NCOA3(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2855594	19	6	19	6	6	3	4	2	3	1	0.430	0.938	1.000
149	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(4), MEF2A(2), MEF2D(1), YWHAH(1)	1099767	11	2	11	3	1	2	5	1	2	0	0.534	0.938	1.000
150	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	1485591	12	5	12	2	7	2	2	0	1	0	0.108	0.939	1.000
151	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(1), ABAT(1), ADSL(2), ADSS(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), CAD(5), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), PC(2)	3436823	37	10	37	10	9	8	12	5	2	1	0.197	0.939	1.000
152	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(4), AKT1(2), BAD(1), CSF2RB(2), IGF1R(3), IL3RA(1), KIT(4), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1)	2968072	29	8	29	5	8	7	3	6	5	0	0.0409	0.939	1.000
153	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	294107	3	1	3	0	0	1	2	0	0	0	0.408	0.939	1.000
154	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	31	AARS(1), ABAT(1), ADSL(2), ADSS(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(1), CAD(5), DARS(1), DARS2(1), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), NARS2(2), PC(2), PDHA1(1)	4800780	48	15	48	13	12	11	12	7	5	1	0.135	0.942	1.000
155	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), MUT(2)	684217	3	1	3	2	0	0	0	1	2	0	0.905	0.944	1.000
156	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1104732	5	3	5	2	3	0	2	0	0	0	0.673	0.946	1.000
157	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1104732	5	3	5	2	3	0	2	0	0	0	0.673	0.946	1.000
158	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GGT1(1), SHMT1(1), SHMT2(2)	779743	5	3	5	4	2	1	1	0	0	1	0.875	0.946	1.000
159	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(1), FBXW7(4), RB1(3)	1151734	10	3	10	4	1	3	2	3	1	0	0.759	0.946	1.000
160	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2)	965411	9	4	9	3	3	2	0	2	2	0	0.696	0.947	1.000
161	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1)	1472641	12	4	12	2	6	1	0	2	3	0	0.154	0.949	1.000
162	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPHN(1), SRC(2), UBQLN1(3)	1665425	19	4	19	2	6	4	4	2	2	1	0.0346	0.950	1.000
163	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(1), MMP2(2), MMP9(2), RECK(3)	885158	8	2	8	3	5	0	1	0	2	0	0.563	0.950	1.000
164	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(3), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1)	2518007	22	7	21	4	4	5	4	1	8	0	0.309	0.952	1.000
165	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(4), APOA4(2), APOC1(1), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(3), LPL(2), LRP1(12), SCARB1(1), SOAT1(1)	3769470	32	11	32	9	13	7	3	2	6	1	0.148	0.953	1.000
166	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1)	2283944	13	7	13	3	3	3	1	2	4	0	0.295	0.953	1.000
167	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(1), DHRS3(2), PON1(1), PON2(1)	2502339	24	8	23	6	8	4	2	5	5	0	0.256	0.954	1.000
168	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(1), AKT3(1), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1)	1922058	15	8	15	8	6	1	2	2	4	0	0.837	0.954	1.000
169	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1)	1544248	14	4	14	3	6	1	0	3	4	0	0.256	0.955	1.000
170	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	6	HSD11B1(1), LPL(2), NR3C1(2), PPARG(1)	764201	6	1	6	1	2	0	2	1	1	0	0.403	0.955	1.000
171	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), UGDH(1)	1183983	6	3	6	3	3	0	2	1	0	0	0.766	0.958	1.000
172	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(5), CDH1(1), CREBBP(2), EP300(4), TGFB1(1), TGFB2(2), TGFBR2(5)	3228324	20	7	19	6	7	1	3	4	5	0	0.532	0.959	1.000
173	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), NFKBIA(2), RELA(1)	1268527	6	2	6	1	0	1	2	2	1	0	0.546	0.959	1.000
174	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	14	CD44(3), CSF1(2), IL1B(1), IL6R(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3)	1531935	17	5	16	7	6	1	3	4	3	0	0.643	0.960	1.000
175	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(8), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1)	2342244	25	9	25	8	10	5	7	1	2	0	0.280	0.960	1.000
176	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(2)	1611423	9	4	9	2	3	1	2	0	3	0	0.482	0.961	1.000
177	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	5	CDK5R1(1), DAB1(1), LRP8(1), RELN(7), VLDLR(1)	1671573	11	4	11	6	3	2	2	1	2	1	0.909	0.961	1.000
178	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	359143	3	1	3	1	0	1	1	1	0	0	0.760	0.961	1.000
179	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), MAF(2), NFATC1(4), NFATC2(5), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1728743	19	5	18	7	8	5	2	0	4	0	0.283	0.961	1.000
180	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(1), CR1(3), FCGR2B(1), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2)	1782807	14	7	14	3	5	2	1	2	4	0	0.268	0.962	1.000
181	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), GREB1(4), MTA1(1), PDZK1(1), TUBA8(4)	1552600	12	4	12	2	0	8	1	1	2	0	0.0728	0.963	1.000
182	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1)	2647346	19	8	19	6	2	4	6	4	3	0	0.618	0.963	1.000
183	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3)	856979	9	2	9	3	3	0	1	2	3	0	0.580	0.964	1.000
184	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDK7(1)	839984	1	1	1	1	0	0	0	0	1	0	0.904	0.964	1.000
185	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1), FOSL2(2), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(1), TNFRSF11A(2)	1538193	11	2	11	3	0	2	3	5	1	0	0.525	0.965	1.000
186	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	7	GCK(1), HK1(1), HK2(3), HK3(2), PGM3(1)	1230533	8	2	8	4	4	1	2	0	1	0	0.680	0.965	1.000
187	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(1), HRAS(1), IGF1R(3), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SRF(1)	2717949	15	7	15	4	4	2	0	4	5	0	0.416	0.965	1.000
188	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(1), HMGB1(1), TOP2A(1), TOP2B(4)	1285166	8	4	8	2	3	2	0	1	2	0	0.606	0.966	1.000
189	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	10	ARNTL(1), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(4), PER2(3), PER3(1)	2144632	15	5	14	3	4	2	2	3	4	0	0.277	0.966	1.000
190	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(9), FASN(7), MCAT(1), OLAH(2)	2276042	23	6	22	3	8	6	2	1	5	1	0.0193	0.967	1.000
191	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1B(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	1952302	17	4	17	5	2	5	7	1	2	0	0.487	0.967	1.000
192	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(3), DDC(1), GAD1(6), GAD2(5), SLC18A3(2), TH(1), TPH1(2)	2034870	23	9	23	9	7	2	9	2	2	1	0.554	0.967	1.000
193	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), LEPR(5), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2)	1979071	14	3	14	1	0	6	1	2	5	0	0.0548	0.967	1.000
194	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(4), DDX20(1), E2F4(4), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(5)	3697332	28	10	26	8	5	8	5	4	6	0	0.358	0.967	1.000
195	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(5), AXIN1(5), BTRC(1), CREBBP(2), CSNK1D(1), CSNK2A1(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1)	3970551	41	11	41	5	13	8	7	8	5	0	0.00656	0.969	1.000
196	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), PC(2), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(2)	2837228	23	6	22	2	5	4	6	4	4	0	0.0423	0.971	1.000
197	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	15	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB5(2)	1053450	8	4	8	3	2	0	3	1	2	0	0.731	0.971	1.000
198	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(5), AXIN1(5), BTRC(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NOTCH1(7), PSEN1(1), WNT1(1)	3072054	41	8	41	7	15	13	4	6	3	0	0.00664	0.971	1.000
199	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(4), CTNNB1(8), PTK2(4), PXN(1), SRC(2), VCL(1)	2699126	32	7	32	5	14	10	2	5	1	0	0.00823	0.971	1.000
200	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(2), SCAP(3), SREBF1(1), SREBF2(5)	1732184	11	6	9	9	2	2	0	2	5	0	0.985	0.972	1.000
201	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(2), NAT2(1), XDH(6)	1085665	16	6	16	7	6	2	1	4	3	0	0.736	0.972	1.000
202	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3)	2866339	32	8	32	8	7	6	6	7	6	0	0.224	0.972	1.000
203	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(5)	1455959	14	3	13	1	5	3	3	1	2	0	0.0620	0.973	1.000
204	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(1)	462012	3	1	3	0	0	3	0	0	0	0	0.378	0.974	1.000
205	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CDK4(2), CDK6(2), CDK7(1), RB1(3), RBL1(1)	2025532	16	4	16	4	2	4	5	4	1	0	0.345	0.975	1.000
206	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	1195423	7	3	7	4	3	0	2	0	2	0	0.792	0.975	1.000
207	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(1), SRF(1), STAT5A(1)	3858202	23	11	23	4	8	3	4	3	5	0	0.123	0.975	1.000
208	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(3), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	1816641	15	5	14	3	5	2	2	2	4	0	0.345	0.976	1.000
209	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(1), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), NOS1(7), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	3345214	38	10	38	12	15	6	6	7	4	0	0.299	0.978	1.000
210	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	10	BCAT1(2), DPYD(3), ENPP3(2), PANK1(1), PANK4(2), UPB1(2)	1692222	12	5	12	2	3	4	1	2	2	0	0.223	0.978	1.000
211	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX3(1), PLA2G3(2), PLA2G6(4)	1292474	7	2	7	6	0	2	3	1	1	0	0.983	0.979	1.000
212	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(3), OGDH(3), SDHA(3), SUCLA2(1)	1289002	11	2	11	1	3	1	3	2	2	0	0.144	0.979	1.000
213	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(2)	1495890	8	3	8	3	3	0	3	2	0	0	0.634	0.979	1.000
214	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4)	424787	6	2	6	2	1	1	1	3	0	0	0.698	0.979	1.000
215	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(2), APAF1(3), ATM(8), BAD(1), CASP7(1), CASP9(1), PTK2(4), PXN(1), STAT1(1), TLN1(9)	3608085	31	6	31	5	7	8	6	5	5	0	0.0707	0.980	1.000
216	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1)	1551581	7	2	7	0	3	1	1	2	0	0	0.106	0.981	1.000
217	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
218	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
219	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	2078229	12	4	12	3	2	2	4	2	2	0	0.469	0.981	1.000
220	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(2), BECN1(1), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(2), ULK3(1)	2944437	21	7	21	4	5	4	1	7	4	0	0.193	0.981	1.000
221	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	18	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), UBE3A(5)	1632333	12	5	11	2	4	0	3	2	3	0	0.360	0.982	1.000
222	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	EPO(1), EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1)	1538574	9	2	9	1	2	1	5	0	1	0	0.334	0.982	1.000
223	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(1), AKT3(1), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), PTEN(2), RBL2(2), SHC1(1)	2447918	19	9	19	7	3	3	5	4	4	0	0.644	0.983	1.000
224	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(8), ATR(9), BRCA1(5), CDC25C(2), CDC34(1), EP300(4), MDM2(2), MYT1(10), PRKDC(7), RPS6KA1(2), YWHAH(1)	5559295	51	22	48	12	9	8	8	12	14	0	0.341	0.983	1.000
225	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MANBA(2), NEU4(1)	2329794	15	7	15	4	6	1	2	0	6	0	0.380	0.983	1.000
226	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), SHC1(1)	4722675	37	12	37	6	10	8	9	2	8	0	0.0247	0.983	1.000
227	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1)	1903223	7	2	7	3	0	2	1	2	2	0	0.627	0.984	1.000
228	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(7), ATM(8), ATR(9), CCNA1(3), CCNE1(1), CDK4(2), CDK6(2), DHFR(1), GSK3B(1), RB1(3), SKP2(2), TGFB1(1), TGFB2(2)	3841573	42	16	40	11	6	7	11	7	11	0	0.459	0.984	1.000
229	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), SH3GLB1(1)	2106530	8	3	8	2	1	1	1	3	2	0	0.590	0.985	1.000
230	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), ST8SIA1(2)	2173447	16	5	16	2	9	4	2	0	1	0	0.0385	0.985	1.000
231	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(1), GLB1(3), HEXB(2), LCT(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1)	2180014	22	8	21	7	9	3	2	0	8	0	0.277	0.985	1.000
232	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	14	ABCG2(1), BCHE(5), CES1(1), CYP3A5(1), UGT1A10(1), UGT1A3(1)	2380967	10	7	9	7	0	1	2	3	3	1	0.980	0.986	1.000
233	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(5), CREBBP(2), CTNNB1(8), DVL1(4), EP300(4), FZD1(5), GSK3B(1), LDB1(1), LEF1(3), TRRAP(9), WNT1(1)	4599247	48	11	47	8	17	9	6	11	5	0	0.0116	0.986	1.000
234	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), KERA(2), LUM(1)	496834	4	1	4	1	0	0	1	3	0	0	0.674	0.986	1.000
235	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), SCAP(3), SREBF1(1), SREBF2(5)	2449203	20	7	18	6	4	5	1	1	9	0	0.496	0.986	1.000
236	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(1), VKORC1(3)	1554661	16	3	16	6	3	5	6	1	1	0	0.524	0.986	1.000
237	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	15	ACE2(1), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(4), LNPEP(2), MME(2), NLN(1), THOP1(1)	2455519	20	6	20	4	3	6	6	4	1	0	0.136	0.987	1.000
238	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCR(1), CRKL(2), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), STAT1(1), STAT5A(1)	3508640	22	9	22	6	4	2	5	5	6	0	0.497	0.987	1.000
239	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(2), EIF4B(3), EIF4G1(7), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2), TSC1(1), TSC2(6)	3818174	40	15	39	10	9	10	10	5	6	0	0.266	0.987	1.000
240	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1)	2211453	13	4	13	4	2	2	5	2	2	0	0.564	0.987	1.000
241	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	11	ACAA1(1), ACOX3(1), ELOVL6(1), FADS1(1), FASN(7), HADHA(1), HSD17B12(1)	1850619	13	3	13	3	3	4	3	0	2	1	0.161	0.987	1.000
242	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), FURIN(2), NOTCH1(7), PSEN1(1)	1369260	13	2	13	6	6	6	1	0	0	0	0.336	0.987	1.000
243	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(2), RPL10A(1), RPL10L(2), RPL11(1), RPL18(2), RPL18A(1), RPL22L1(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(2), RPL3L(2), RPS11(2), RPS25(1), RPS27(1), RPS28(1), RPSA(1)	3143933	25	10	23	7	7	2	4	0	12	0	0.742	0.988	1.000
244	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(2)	1252099	11	2	10	5	2	1	5	1	2	0	0.871	0.988	1.000
245	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), PRKACG(2), PRKAR2B(1)	1392069	7	2	7	3	1	2	2	1	1	0	0.830	0.988	1.000
246	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GLS(2), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(1)	4582693	44	12	44	10	8	7	14	6	7	2	0.167	0.988	1.000
247	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), OGDHL(2), PC(2), PCK1(3), PCK2(4), SDHA(3), SUCLA2(1), SUCLG1(2)	4103283	34	9	32	6	11	4	7	4	7	1	0.0865	0.989	1.000
248	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), BAD(1), CASP9(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1)	2623166	18	8	18	6	2	5	3	4	4	0	0.598	0.989	1.000
249	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	JUND(1)	450994	1	1	1	0	0	0	0	1	0	0	0.801	0.989	1.000
250	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	CDK5R1(1), CSNK1D(1), DRD1(2), PLCB1(1), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1798348	14	2	14	3	7	2	1	4	0	0	0.219	0.989	1.000
251	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TPO(4), TYR(3)	1340179	19	5	19	8	9	0	5	2	3	0	0.696	0.990	1.000
252	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CAPNS1(3), CAPNS2(1), EP300(4), MEF2D(1), NFATC1(4), NFATC2(5), PPP3CA(1), PPP3CC(2)	3357673	25	10	24	8	5	6	0	4	10	0	0.494	0.990	1.000
253	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), EHHADH(1), HADHA(1)	1681105	7	3	7	2	4	0	3	0	0	0	0.510	0.990	1.000
254	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), DCT(5), DDC(1), GOT1(2), HGD(2), HPD(2), TAT(1), TH(1), TPO(4), TYR(3)	4393947	48	12	47	16	20	8	8	6	6	0	0.210	0.990	1.000
255	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD86(1), HLA-DRB1(1), IFNGR1(1), IL12B(1), IL12RB2(1), IL2RA(1), IL4R(1)	1650334	7	4	7	3	1	1	0	3	2	0	0.754	0.990	1.000
256	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	10	APEX1(1), CREBBP(2), DFFB(1), NME1(1), SET(1)	1319545	6	3	6	2	2	0	1	1	2	0	0.698	0.990	1.000
257	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	BCMO1(2)	530069	2	1	2	0	1	0	0	1	0	0	0.530	0.990	1.000
258	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(5), ODC1(1), SAT2(1)	4104870	25	8	24	3	11	5	5	2	1	1	0.0180	0.991	1.000
259	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT2(1), B3GNT7(1), CHST2(2), CHST4(1), CHST6(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1647120	13	4	13	2	5	1	4	2	1	0	0.130	0.991	1.000
260	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELP(3)	2203724	15	5	15	5	5	3	1	3	3	0	0.374	0.991	1.000
261	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2)	1446344	12	4	12	3	4	2	1	3	2	0	0.297	0.991	1.000
262	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1830349	19	3	19	7	7	5	4	2	1	0	0.470	0.992	1.000
263	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	8	HK1(1), LCT(3), PYGM(1), TPI1(2), TREH(1)	1686318	8	2	8	9	1	2	1	1	3	0	0.975	0.992	1.000
264	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1), TPI1(2)	532396	4	1	4	0	1	2	0	1	0	0	0.218	0.992	1.000
265	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(1), AKT3(1), IARS(4), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(4), SHC1(1), SOS2(1), SRC(2), STAT6(4), TYK2(2)	4755971	30	10	30	8	8	6	5	5	6	0	0.245	0.992	1.000
266	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	12	ARHGAP5(3), ARHGEF1(4), GNAQ(1), GNB1(2), MYLK(8), PLCB1(1), ROCK1(3)	2553126	22	6	22	7	4	6	4	4	4	0	0.457	0.993	1.000
267	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(8), CCND2(2), CDK4(2), ESR2(1), FSHR(2), GJA4(1), LHCGR(1), MLH1(1), NCOR1(7), NRIP1(1), PGR(3), PRLR(3), ZP2(1)	4698408	33	8	33	7	8	5	8	7	5	0	0.143	0.993	1.000
268	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5)	2904624	27	7	27	4	10	6	3	3	5	0	0.0295	0.993	1.000
269	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5)	2904624	27	7	27	4	10	6	3	3	5	0	0.0295	0.993	1.000
270	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2)	1652444	10	4	10	6	3	2	3	0	2	0	0.856	0.993	1.000
271	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	ASNS(3), ASRGL1(1), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), GLUD2(1), HAL(1)	2843531	19	6	19	4	4	8	2	1	3	1	0.184	0.993	1.000
272	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5E(1), NT5M(1)	2009279	16	2	16	3	5	4	2	3	2	0	0.144	0.994	1.000
273	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(1), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SRF(1), STAT1(1), STAT3(2), STAT5A(1)	4453521	26	9	26	6	6	5	4	5	6	0	0.277	0.994	1.000
274	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), GGT1(1), PAPSS1(3), PAPSS2(3), SCLY(2)	1715261	11	4	11	9	4	2	2	1	2	0	0.945	0.994	1.000
275	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G3(2), PLA2G6(4), RDH11(2)	3298698	28	7	28	9	7	3	9	6	3	0	0.592	0.994	1.000
276	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGAL(3), ITGB2(1), SELE(2)	1665164	11	4	11	5	4	1	1	3	2	0	0.675	0.994	1.000
277	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA6(2), CYP11A1(2), EDN1(3), EDNRB(2), HSD11B1(1), PTGDR(2), PTGDS(3), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	2720260	21	7	20	6	9	2	4	2	4	0	0.388	0.994	1.000
278	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(1), BIRC2(1), CASP7(1), CASP8(2), CASP9(1), DFFB(1)	1811829	10	2	10	4	2	3	1	1	3	0	0.709	0.995	1.000
279	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	14	BCAT1(2), BCAT2(1), DPYD(3), ENPP3(2), ILVBL(2), PANK1(1), PANK4(2), UPB1(2), VNN1(1)	2160503	16	5	16	2	5	5	2	2	2	0	0.0793	0.995	1.000
280	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(4), TRH(2)	1492774	10	3	10	4	4	1	2	1	2	0	0.656	0.995	1.000
281	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(1), TLR2(2), TLR4(1), TLR7(1), TLR9(5)	2560893	21	7	21	7	8	5	3	5	0	0	0.408	0.995	1.000
282	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1), UQCRH(1)	4984670	34	12	34	7	9	4	6	8	7	0	0.197	0.995	1.000
283	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), STAT1(1), STAT3(2), STAT5A(1), THPO(1)	3753020	17	7	17	3	3	5	2	2	5	0	0.178	0.995	1.000
284	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), HAL(1), PRPS1(1)	3371480	19	9	18	5	8	5	4	1	1	0	0.198	0.995	1.000
285	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	24	BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1)	3449742	19	8	19	4	2	3	2	5	7	0	0.487	0.996	1.000
286	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), ESCO1(3), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TAT(1), TPO(4)	4559160	38	10	37	7	18	5	6	5	4	0	0.0289	0.996	1.000
287	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATM(8), ATR(9), BRCA1(5), BRCA2(7), FANCA(3), FANCC(2), FANCD2(4), FANCG(1), HUS1(1), MRE11A(3), RAD1(1), RAD9A(1), TREX1(2)	5713347	47	20	44	11	7	9	5	9	17	0	0.446	0.996	1.000
288	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NEU4(1)	2869103	18	7	18	6	8	1	2	0	7	0	0.428	0.997	1.000
289	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	20	ASNS(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), HAL(1)	2533498	17	5	17	3	4	6	2	1	3	1	0.171	0.997	1.000
290	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(2), DAXX(4), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1)	2543869	20	5	19	6	6	2	5	4	3	0	0.504	0.997	1.000
291	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SRF(1), STAT1(1), STAT3(2), STAT5A(1)	4802429	27	9	27	6	4	6	4	6	7	0	0.248	0.997	1.000
292	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	11	CASR(3), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM7(5), GRM8(3)	2288279	37	11	36	11	8	12	5	5	7	0	0.221	0.997	1.000
293	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	20	AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT12(1)	2697413	19	3	19	4	6	4	3	3	3	0	0.186	0.997	1.000
294	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1), HADHA(1)	668241	2	1	2	0	1	0	1	0	0	0	0.545	0.997	1.000
295	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPLD1(2), PGAP1(1), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGQ(5), PIGS(3), PIGW(2)	3283446	21	6	21	3	6	4	4	4	3	0	0.0555	0.997	1.000
296	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PDHA1(1), PKLR(2)	5092832	37	8	36	8	9	14	4	3	7	0	0.0811	0.997	1.000
297	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), AGTR2(1), EDN1(3), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1)	2828007	16	4	15	1	2	3	4	1	6	0	0.0461	0.997	1.000
298	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IL12B(1), IL12RB2(1), IL4R(1), TGFB1(1), TGFB2(2)	2588041	19	7	18	8	4	4	2	5	4	0	0.699	0.997	1.000
299	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(3), EEF1D(2), EEF1G(3), EEF2(3), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(7), EIF4G3(7), EIF5(1), GSPT2(1), PABPC3(5), SLC35A4(2)	5610537	46	11	45	8	8	10	13	6	9	0	0.0879	0.997	1.000
300	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), LCT(3), NAGLU(2)	2042627	15	7	15	7	4	3	1	2	5	0	0.697	0.998	1.000
301	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKL(2), PFKM(2), PGD(1), PGLS(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1), TKTL1(1)	3186518	23	5	23	6	6	5	8	2	2	0	0.198	0.998	1.000
302	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(2), EP300(4), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1)	3727846	21	10	20	9	6	4	3	3	5	0	0.691	0.998	1.000
303	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3)	2943836	32	8	32	10	7	6	6	7	6	0	0.387	0.998	1.000
304	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3)	1894860	12	5	12	5	6	3	1	1	1	0	0.572	0.998	1.000
305	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3)	767714	12	1	12	4	4	3	2	2	1	0	0.501	0.998	1.000
306	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	16	AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1)	2110623	9	3	9	4	1	1	3	2	2	0	0.860	0.998	1.000
307	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2)	1776581	16	3	16	3	5	2	2	5	2	0	0.248	0.998	1.000
308	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(2), HRAS(1), IL3RA(1), JAK2(2), PTPN6(4), SHC1(1), STAT5A(1)	2071358	12	4	12	3	5	1	3	2	1	0	0.384	0.998	1.000
309	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(2), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), NAGK(1), PPAT(2), QARS(1)	5459691	48	12	48	12	8	9	15	7	7	2	0.191	0.998	1.000
310	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AOC2(5), AOC3(2), CES1(1), DDHD1(2), ESCO1(3), LIPA(1), PLA1A(1), SH3GLB1(1)	3320506	16	6	15	3	6	4	2	3	1	0	0.158	0.998	1.000
311	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(1), ACAT1(2), HADHA(1)	747818	5	1	5	0	0	4	1	0	0	0	0.194	0.998	1.000
312	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	HSD3B7(3), RDH11(2)	669383	5	1	5	0	1	0	2	2	0	0	0.288	0.998	1.000
313	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(2), IL4R(1), JAK1(1), JAK3(3), SHC1(1), STAT6(4)	1726855	12	4	12	8	5	3	1	2	1	0	0.897	0.998	1.000
314	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR4(3), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(1), MC2R(2), MC3R(3), MC5R(2), NPY1R(2), NPY2R(3), NPY5R(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), SSTR1(4), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3)	7153733	74	20	73	20	23	9	21	12	8	1	0.0457	0.998	1.000
315	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(2), SYNJ2(2)	3082711	18	5	18	7	3	4	2	4	5	0	0.683	0.999	1.000
316	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(3), ARG1(1), ARG2(1), ASL(1), ASS1(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(1), GOT1(2), LAP3(2), NOS1(7), NOS3(6), OAT(2), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	4854135	53	14	53	12	17	7	14	8	6	1	0.127	0.999	1.000
317	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(2), AKT1(2), CDC42(1), FLNA(8), FLNC(9), FSCN3(2), GDI2(2), LIMK1(1), MYH2(3), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), ROCK1(3), ROCK2(1), VASP(1), WASF1(1), WASL(5)	6538948	58	19	57	17	10	12	14	11	11	0	0.349	0.999	1.000
318	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(4), ILVBL(2), LARS2(2), PDHA1(1), VARS(2), VARS2(2)	2567615	16	4	16	5	6	4	2	3	1	0	0.499	0.999	1.000
319	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(4), SRC(2), SYK(2), TBXAS1(1)	3367745	23	4	23	8	6	8	3	4	2	0	0.535	0.999	1.000
320	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(2), AKT2(1), AKT3(1), BAD(1), BTK(1), DAPP1(1), GSK3A(1), GSK3B(1), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1), TEC(2), YWHAE(2), YWHAH(1)	4551779	32	11	32	9	7	8	3	5	9	0	0.309	0.999	1.000
321	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(3), F2RL1(1), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(1), PLD2(3), PLD3(1), PTK2(4), RASAL1(5), SRC(2), TEC(2), VAV1(4)	3839257	37	5	37	8	10	12	6	3	5	1	0.0430	0.999	1.000
322	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(2), GNB1(2), HRAS(1), IGF1R(3), KLK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(1), SHC1(1), SRC(2), STAT3(2)	3950126	22	9	22	8	8	6	2	3	3	0	0.427	0.999	1.000
323	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), OGT(1), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1)	4445385	27	8	27	8	8	5	7	4	3	0	0.352	0.999	1.000
324	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(2), ACOT11(2), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1)	3407829	16	5	16	3	4	3	3	3	3	0	0.273	0.999	1.000
325	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6)	6224212	54	15	52	11	18	8	4	11	13	0	0.0647	0.999	1.000
326	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(3)	2359633	19	5	19	8	5	2	7	3	2	0	0.774	0.999	1.000
327	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(2), MAP3K1(3), NCOR2(4), THRA(2), THRB(1)	2435338	14	5	14	9	3	3	3	2	3	0	0.950	0.999	1.000
328	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	691247	1	1	1	1	1	0	0	0	0	0	0.845	0.999	1.000
329	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	22	ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKM(2), PGD(1), PGLS(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1)	2643201	20	3	20	7	5	4	8	2	1	0	0.392	0.999	1.000
330	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(4), CREB1(2), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	4570388	36	9	35	9	10	10	2	5	9	0	0.152	0.999	1.000
331	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(7), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1)	5098330	40	10	40	8	11	2	11	7	9	0	0.187	0.999	1.000
332	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), BDH1(1), DDHD1(2), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2)	5625967	44	12	44	10	11	11	11	8	2	1	0.0696	0.999	1.000
333	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TKTL1(1), TPI1(2)	2788686	21	4	21	2	3	5	8	2	3	0	0.0377	0.999	1.000
334	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(1), DAPP1(1), FLOT1(1), FLOT2(2), ITPR1(6), ITPR2(9), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(6), PREX1(8), PTEN(2), PTPRC(2), RPS6KA1(2), RPS6KA2(1), SYK(2), TEC(2), VAV1(4)	7617683	69	23	65	14	20	11	9	11	17	1	0.0365	0.999	1.000
335	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(7), ITGB3(1), PTK2(4), PXN(1), SPTAN1(3), SRC(2), TLN1(9)	3967938	41	8	41	6	13	12	6	4	6	0	0.00453	0.999	1.000
336	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(2), YWHAH(1)	2825938	17	4	17	5	4	3	3	3	4	0	0.454	0.999	1.000
337	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), SH3GLB1(1)	3263266	23	3	23	7	5	7	3	5	3	0	0.393	0.999	1.000
338	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SP1(1)	2902362	21	5	20	6	4	6	2	3	6	0	0.347	0.999	1.000
339	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(3), SP1(1)	913204	5	1	5	0	1	0	3	1	0	0	0.352	0.999	1.000
340	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(2), NOS1(7), NOS3(6), OAT(2), ODC1(1), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1)	6001293	57	15	56	9	23	9	14	6	4	1	0.00436	0.999	1.000
341	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(8), MAP2(3), PPP1CA(1), PPP2CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1)	2493140	17	5	17	6	5	4	2	4	2	0	0.671	0.999	1.000
342	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	50	ARSE(1), CARM1(1), CYP11B1(5), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	6377571	43	14	41	13	7	13	12	5	6	0	0.365	0.999	1.000
343	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(2), KARS(2)	949040	6	2	6	3	1	0	3	1	1	0	0.905	0.999	1.000
344	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(5), CARM1(1), CREBBP(2), EP300(4), ESR1(1), GRIP1(1), GTF2E1(1), GTF2F1(4), HDAC4(4), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(3)	6329201	36	13	32	9	9	6	5	4	12	0	0.330	0.999	1.000
345	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(7), CACNA1B(9), GNB1(2), GNB3(2), GNG13(1), GRM4(1), ITPR3(8), KCNB1(5), PLCB2(4), PRKACG(2), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(5), TAS1R2(3), TAS1R3(2), TAS2R1(2), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R9(2), TRPM5(1)	7776195	80	23	77	17	30	11	12	10	17	0	0.00670	0.999	1.000
346	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARF1(1), ARFGAP1(1), ARFGEF2(2), CLTB(2), COPA(2), GBF1(3), GPLD1(2), KDELR3(1)	2084329	14	3	14	4	4	2	3	3	1	1	0.411	0.999	1.000
347	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(3), NR1H4(1)	744421	4	2	4	2	1	2	1	0	0	0	0.621	0.999	1.000
348	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	2115781	18	6	18	9	10	1	3	1	3	0	0.784	1.000	1.000
349	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(3), DIAPH1(4), HRAS(1), ITGA1(7), MYLK(8), PIK3CA(4), PIK3R1(1), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9)	4781881	48	10	48	10	12	15	8	7	6	0	0.0558	1.000	1.000
350	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TPI1(2)	2500132	22	3	22	2	3	6	8	3	2	0	0.0222	1.000	1.000
351	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SGMS1(2), SGPP1(1), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(1)	5034998	33	9	32	10	13	6	3	6	5	0	0.181	1.000	1.000
352	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	38	ALAS2(2), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTMT(2), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	5444974	28	10	28	7	3	9	3	5	8	0	0.336	1.000	1.000
353	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(1), CREBBP(2), EP300(4), IKBKB(2), IL1B(1), MAP2K6(2), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR2(5), TLR2(2)	3825261	25	6	25	6	6	4	6	4	5	0	0.231	1.000	1.000
354	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), CARM1(1), DDC(1), FTCD(3), HAL(1), HARS2(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), UROC1(4)	5495100	42	13	40	8	12	11	11	3	5	0	0.0291	1.000	1.000
355	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP1(1)	858410	1	1	1	0	0	0	1	0	0	0	0.841	1.000	1.000
356	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(2), JAK1(1), JAK2(2), JAK3(3), STAT1(1), STAT3(2), STAT5A(1), TYK2(2)	2581639	16	6	16	8	7	2	4	1	2	0	0.748	1.000	1.000
357	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(1), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	3408012	29	6	29	7	7	5	9	4	4	0	0.254	1.000	1.000
358	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(4), LPL(2), NCOA2(2), PPARG(1)	2535211	11	4	11	9	4	1	2	1	3	0	0.976	1.000	1.000
359	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	22	AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), XYLB(2)	3278915	14	5	14	5	1	4	4	2	3	0	0.734	1.000	1.000
360	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(2), LDHB(1)	942061	3	1	3	2	1	0	1	1	0	0	0.935	1.000	1.000
361	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1)	998288	5	1	5	1	0	4	0	0	1	0	0.365	1.000	1.000
362	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	2453807	17	2	17	5	3	2	4	4	3	1	0.392	1.000	1.000
363	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CD4(2), CREB1(2), CTSB(2), CTSS(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), HSP90AB1(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1), TAP2(1), TAPBP(1)	6223972	45	19	44	13	7	11	6	8	13	0	0.384	1.000	1.000
364	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	19	ALG5(1), B4GALT5(2), DDOST(1), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), ST6GAL1(1)	2574591	12	4	12	6	4	1	1	4	2	0	0.869	1.000	1.000
365	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CYP2C9(1), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), HADHA(1), SH3GLB1(1)	4094507	18	7	18	6	7	1	4	3	3	0	0.607	1.000	1.000
366	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2)	3051954	26	6	26	9	8	5	7	3	3	0	0.465	1.000	1.000
367	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(1), FTCD(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	2521871	20	3	20	5	4	3	4	5	3	1	0.249	1.000	1.000
368	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(1), PFKL(2), PFKM(2), PLCG1(1), PRKCE(1)	3540443	18	4	18	4	3	7	3	2	3	0	0.149	1.000	1.000
369	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DGAT1(3), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GLB1(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PPAP2B(2)	6583003	59	12	59	19	26	7	9	8	9	0	0.178	1.000	1.000
370	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DGAT1(3), DGAT2(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), GK2(4), GLB1(3), GPAM(3), LCT(3), LIPA(1), LIPF(2), LIPG(3), LPL(2), MGLL(2), PNLIP(1), PPAP2B(2)	8024838	75	15	75	23	30	11	14	11	9	0	0.114	1.000	1.000
371	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K6(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2), TOLLIP(1)	3962940	23	7	22	8	4	2	5	5	7	0	0.702	1.000	1.000
372	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(8), NCF2(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), RALBP1(2), TRIO(9), VAV1(4), WASF1(1)	4289581	39	9	38	11	11	9	5	6	6	2	0.257	1.000	1.000
373	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	2870998	16	3	16	7	3	1	5	3	4	0	0.862	1.000	1.000
374	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(5), AXIN1(5), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(8), DVL1(4), DVL2(3), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PPP2R5C(2), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PRKD1(2), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2)	7968223	80	23	79	26	33	17	5	14	11	0	0.114	1.000	1.000
375	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(4), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(4), MAP2K6(2), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(5), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), YWHAH(1)	4844684	44	12	43	12	11	9	5	6	13	0	0.195	1.000	1.000
376	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(1), AKT3(1), ASAH1(1), BRAF(3), DAG1(2), EGFR(2), EPHB2(3), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), RGS20(1), SHC1(1), SOS2(1), SRC(2), STAT3(2), TERF2IP(1)	7774322	64	24	60	11	15	9	9	9	22	0	0.0588	1.000	1.000
377	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(4), FH(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), PC(2), PDHA1(1), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(2)	3930041	29	4	29	5	8	4	8	4	5	0	0.0897	1.000	1.000
378	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), EHHADH(1), GCDH(2), HADHA(1)	1073881	6	1	6	0	2	2	2	0	0	0	0.130	1.000	1.000
379	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5)	7086533	67	21	64	12	18	13	8	12	16	0	0.0211	1.000	1.000
380	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5)	7086533	67	21	64	12	18	13	8	12	16	0	0.0211	1.000	1.000
381	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1)	3114139	15	3	15	7	1	4	6	2	2	0	0.864	1.000	1.000
382	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2)	1149350	7	1	7	0	1	3	1	0	2	0	0.101	1.000	1.000
383	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(3), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2)	5846368	41	6	41	10	14	11	7	4	5	0	0.0598	1.000	1.000
384	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	18	GNAQ(1), GNB1(2), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PTK2(4), ROCK2(1)	2790723	13	3	13	7	2	4	2	2	3	0	0.865	1.000	1.000
385	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(2), AKT2(1), AKT3(1), APC(5), AXIN1(5), AXIN2(1), CTNNB1(8), DACT1(3), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(12), MVP(3), NKD1(3), NKD2(1), PSEN1(1), SENP2(1), SFRP1(2), WIF1(2)	5691860	60	17	60	14	21	12	10	8	9	0	0.0592	1.000	1.000
386	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3)	3212961	16	7	15	9	5	3	3	3	2	0	0.876	1.000	1.000
387	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	9	B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1003317	7	2	7	2	3	0	3	1	0	0	0.557	1.000	1.000
388	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	9	ACP5(1), ENPP3(2), RFK(1), TYR(3)	1159571	7	1	7	2	2	3	1	1	0	0	0.508	1.000	1.000
389	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(1), ACACA(4), ACACB(9), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2)	5348738	35	8	35	8	14	6	6	4	5	0	0.136	1.000	1.000
390	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1)	1142547	5	2	5	2	0	1	2	1	1	0	0.774	1.000	1.000
391	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), CHRNA1(3), FLT1(3), FLT4(9), KDR(1), NOS3(6), PDE2A(1), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1)	5693089	58	18	55	10	20	10	12	3	13	0	0.00897	1.000	1.000
392	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(2), CPO(2), HBB(1), HMBS(1)	1126737	6	4	6	4	3	1	1	0	1	0	0.851	1.000	1.000
393	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(8), CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(4), E2F5(3), GBA2(2), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MYT1(10), NACA(9), POLA2(1), POLE(7), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(2), RPA3(2), TNXB(8)	10347133	99	24	99	22	26	16	25	21	10	1	0.0157	1.000	1.000
394	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PCK2(4), PDHA1(1), PKLR(2)	6441941	52	14	50	13	17	14	4	3	13	1	0.0887	1.000	1.000
395	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(1), CAPNS1(3), CAPNS2(1), EGF(2), EGFR(2), HRAS(1), ITGA1(7), MYLK(8), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(4), PXN(1), TLN1(9)	4568671	49	7	49	9	16	14	8	6	5	0	0.00740	1.000	1.000
396	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAPK8(2), NFKBIA(2), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(2), TLR4(1), TLR6(3), TLR7(1), TLR9(5), TOLLIP(1)	4904114	35	10	35	10	10	4	8	7	6	0	0.390	1.000	1.000
397	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), ASAH1(1), CAMP(2), CERK(1), CREB1(2), DAG1(2), EPHB2(3), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1)	4025765	34	8	34	10	10	4	4	7	9	0	0.317	1.000	1.000
398	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2)	4556690	26	4	26	4	7	6	6	5	2	0	0.0898	1.000	1.000
399	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), PON1(1)	4052828	42	12	40	14	15	5	8	7	7	0	0.409	1.000	1.000
400	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(2), SPTLC2(1), UGCG(1)	3398444	19	4	19	7	7	5	1	1	5	0	0.384	1.000	1.000
401	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), DFFB(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(3), TNFRSF10B(2), TNFSF12(1), TRADD(1), TRAF2(1)	4682039	28	6	28	7	8	5	5	2	8	0	0.247	1.000	1.000
402	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	38	APAF1(3), BAK1(1), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), FAS(2), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), PARP1(5), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	4889518	36	12	34	12	7	4	12	4	8	1	0.712	1.000	1.000
403	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(1), GOT1(2), TAT(1)	1195184	6	3	5	2	1	1	3	1	0	0	0.744	1.000	1.000
404	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(9), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), PRIM1(1), RFC1(4), RFC2(1), RFC3(1), RPA1(1), RPA2(2), RPA3(2), RPS27A(1), UBB(1)	7019158	57	17	57	14	16	7	14	9	10	1	0.195	1.000	1.000
405	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(3), BAD(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(4), DFFB(1), FAS(2), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(6), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	6023045	51	15	47	15	11	10	11	5	14	0	0.520	1.000	1.000
406	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLG(4), POLH(1), POLI(1), POLK(3), POLL(2), POLM(3), POLQ(2), PRIM1(1), REV1(1), REV3L(3)	5643269	35	8	34	5	7	6	7	10	5	0	0.0457	1.000	1.000
407	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(5), AR(3), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(2), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2)	7462220	66	23	61	16	16	7	10	9	24	0	0.241	1.000	1.000
408	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG2(2), ADCY3(6), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1F(1), ERO1L(1), PDIA4(1), PLCG1(1), PLCG2(6), SEC61A1(1), SEC61A2(2), SEC61G(1)	4803480	36	7	36	12	11	7	8	6	4	0	0.346	1.000	1.000
409	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(4), LARS2(2), PDHA1(1)	1369898	9	3	9	3	3	2	1	3	0	0	0.597	1.000	1.000
410	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(6), PSEN1(1)	1254241	10	2	10	3	1	5	1	2	1	0	0.523	1.000	1.000
411	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), LPO(4), MPO(2), TPO(4)	1163833	14	4	14	5	8	0	3	1	2	0	0.510	1.000	1.000
412	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(5), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), RYR1(18)	6404613	60	19	56	15	22	5	11	7	15	0	0.158	1.000	1.000
413	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	39	ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG5(1), ALG9(1), DDOST(1), DHDDS(1), DOLPP1(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1)	5715268	33	9	33	10	10	7	5	7	4	0	0.380	1.000	1.000
414	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL2(1), CUL3(1), FBXW11(1), FBXW7(4), ITCH(2), SKP1(1), SKP2(2), TCEB1(1), TCEB2(1), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(3)	5575104	38	10	37	10	11	9	6	6	6	0	0.322	1.000	1.000
415	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CHUK(1), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(5), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1)	3746242	29	6	28	10	7	6	5	4	7	0	0.527	1.000	1.000
416	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(1), GTF2E2(2), GTF2F1(4), GTF2H1(1), GTF2H4(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(7), TAF1L(3), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(3), TAF6(1), TAF6L(3), TAF7L(1)	4963264	39	16	35	12	8	3	9	6	13	0	0.850	1.000	1.000
417	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(7), ATM(8), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), DTX4(1), E2F3(3), E2F4(4), E2F5(3), EP300(4), ESPL1(5), GSK3B(1), HDAC4(4), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), RB1(3), RBL1(1), SKP2(2), TBC1D8(2), TGFB1(1)	14819734	112	29	110	17	27	17	26	23	18	1	0.00104	1.000	1.000
418	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	3669992	20	4	20	8	5	2	6	4	3	0	0.693	1.000	1.000
419	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(4), CRK(1), CRKL(2), DOCK1(2), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), PXN(1), RAP1B(2), RASA1(1), SRC(2), STAT3(2)	5676968	45	12	45	14	9	15	6	7	8	0	0.302	1.000	1.000
420	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), CARM1(1), DCT(5), DDC(1), ESCO1(3), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TPO(4), TYR(3)	8054762	69	13	68	19	23	14	15	9	8	0	0.0929	1.000	1.000
421	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(2), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), WDR1(2)	1362277	13	2	13	5	4	2	1	5	1	0	0.568	1.000	1.000
422	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	67	ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), EGFR(2), EP300(4), ERBB2(6), FARP2(1), FER(6), IGF1R(3), INSR(4), IQGAP1(1), LEF1(3), LMO7(5), MET(4), MLLT4(4), NLK(1), PARD3(6), PTPN6(4), PTPRB(10), PTPRJ(2), PTPRM(6), PVRL3(1), PVRL4(1), RAC2(1), RHOA(1), SMAD3(1), SORBS1(1), SRC(2), SSX2IP(1), TCF7(2), TCF7L1(3), TCF7L2(1), TGFBR2(5), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASL(5), YES1(1)	14957286	144	30	139	20	37	31	24	25	26	1	2.80e-05	1.000	1.000
423	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(1), KYNU(1), TDO2(1), TPH1(2), WARS(2)	7580798	58	14	56	18	19	8	16	9	6	0	0.336	1.000	1.000
424	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(1)	1481672	7	1	7	3	2	3	2	0	0	0	0.738	1.000	1.000
425	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	57	A4GALT(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGQ(5), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1)	6562649	50	14	49	10	21	10	8	4	7	0	0.0111	1.000	1.000
426	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(2), SOAT1(1)	4246528	38	7	38	11	11	8	11	5	3	0	0.225	1.000	1.000
427	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3E(1), HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), PTPN7(1), RASA1(1), RELA(1), SHC1(1), VAV1(4), ZAP70(5)	6099509	49	11	48	11	11	11	8	8	10	1	0.0923	1.000	1.000
428	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK2(3), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SYK(2), VAV1(4)	5577681	47	11	46	14	11	11	6	8	10	1	0.326	1.000	1.000
429	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(8), ATR(9), BAI1(3), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK6(2), EI24(1), FAS(2), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN2(2), SESN3(2), STEAP3(2), TNFRSF10B(2), TSC2(6), ZMAT3(2)	8609913	72	22	71	22	20	16	15	9	12	0	0.296	1.000	1.000
430	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(2), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2)	7838949	64	10	64	18	24	15	12	5	8	0	0.0767	1.000	1.000
431	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(2), SHC1(1), SYK(2), VAV1(4)	4118563	20	5	20	8	8	2	3	3	3	1	0.613	1.000	1.000
432	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(3), ESR1(1), ESR2(1), ESRRA(2), NR0B1(1), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(3), PPARA(1), PPARD(1), PPARG(1), RARB(2), RARG(2), ROR1(3), RORA(1), RORC(1), THRA(2), THRB(1)	5945212	49	13	47	16	17	9	7	5	11	0	0.260	1.000	1.000
433	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), DLG4(1), LPA(5), MAP2K4(2), MAP3K1(3), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1), PTK2(4), RDX(3), ROCK1(3), ROCK2(1), SRF(1), TBXA2R(2)	6822191	50	13	50	14	8	8	13	10	11	0	0.477	1.000	1.000
434	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(2), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1)	6285969	52	19	48	14	13	7	9	5	18	0	0.423	1.000	1.000
435	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1)	1591340	9	1	9	1	2	2	3	0	2	0	0.256	1.000	1.000
436	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(2), CHAT(3), CPT1B(4), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(6), PPAP2B(2)	7038470	60	13	60	17	21	7	13	9	10	0	0.200	1.000	1.000
437	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(1), HSD17B4(3), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	5840778	38	6	38	8	10	9	9	4	6	0	0.0838	1.000	1.000
438	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(2), PTPRU(6), REG1A(1), STAT1(1)	1574697	12	4	11	6	6	0	3	1	2	0	0.797	1.000	1.000
439	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(4), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PLCG1(1), PLCG2(6), PTPRZ1(3), RELA(1), SRC(2), TCIRG1(1), TJP1(4)	9591564	68	14	67	16	11	16	17	13	11	0	0.100	1.000	1.000
440	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	15	CARS2(2), GOT1(2), LDHB(1), SULT1C4(1), SULT4A1(1)	1599186	7	1	7	4	1	1	2	2	1	0	0.902	1.000	1.000
441	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(1), HK1(1), HK2(3), HK3(2), ISYNA1(1), PGM3(1)	1443947	9	2	9	5	5	1	2	0	1	0	0.692	1.000	1.000
442	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(1), BCKDHB(1), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	4962374	32	5	32	4	7	10	7	3	5	0	0.0173	1.000	1.000
443	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(3), BAD(1), BAK1(1), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(2), FASLG(1), HELLS(1), IKBKB(2), IRF1(2), IRF3(1), IRF5(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), NFKBIE(1), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TRADD(1), TRAF2(1)	7745593	58	17	56	15	11	10	14	7	15	1	0.292	1.000	1.000
444	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	AKT1(2), AKT2(1), AKT3(1), ARHGAP4(1), ARHGEF11(4), BTK(1), CDC42(1), GDI2(2), INPPL1(5), ITPR1(6), ITPR2(9), ITPR3(8), LIMK1(1), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), PTEN(2), RACGAP1(2), ROCK1(3), ROCK2(1), WASF1(1), WASL(5)	9592889	85	26	78	26	17	18	17	10	23	0	0.387	1.000	1.000
445	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CPT1B(4), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3)	6735400	52	5	52	12	17	16	8	5	6	0	0.0296	1.000	1.000
446	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), TRAF2(1), TRAF5(1)	4810431	30	8	30	10	6	8	5	5	6	0	0.298	1.000	1.000
447	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2)	6540505	52	6	52	16	19	12	10	5	6	0	0.160	1.000	1.000
448	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2)	6540505	52	6	52	16	19	12	10	5	6	0	0.160	1.000	1.000
449	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(3), CD1C(1), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(1), CD3E(1), CD4(2), CD44(3), CD5(2), CD55(1), CD59(2), CR1(3), CSF1(2), CSF1R(4), CSF2RA(1), CSF3R(2), DNTT(3), EPO(1), EPOR(2), FCGR1A(1), FLT3(3), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL2RA(1), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(2), THPO(1), TPO(4)	10799283	95	25	92	26	22	16	18	22	17	0	0.161	1.000	1.000
450	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(2), EGFR(2), HGS(2)	1766551	9	1	9	0	0	4	2	2	1	0	0.0535	1.000	1.000
451	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	CCKBR(3), CCR2(1), CELSR1(3), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(2), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(6), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GRPR(1), LGR6(2), LPHN2(6), LPHN3(1), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(2), TSHR(3)	8729648	72	17	72	22	26	13	14	13	6	0	0.0749	1.000	1.000
452	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(2), GNAQ(1), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), HTR2A(2), HTR2B(1), HTR2C(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP3K2(2), MAPK7(4), NPR1(2), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACG(2), PRKCG(2), PRKG1(1), PRKG2(1), SOS2(1), SRC(2), TJP1(4), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1)	17349828	148	35	144	37	50	32	23	20	23	0	0.00510	1.000	1.000
453	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	CBL(4), CSK(1), CTLA4(1), DAG1(2), EPHB2(3), FBXW7(4), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(1), SOS2(1), VAV1(4), ZAP70(5)	6891296	52	11	52	12	18	10	8	7	8	1	0.102	1.000	1.000
454	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(1), STAT2(1), TYK2(2)	1725787	14	5	13	6	8	0	4	1	1	0	0.670	1.000	1.000
455	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(1), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(2), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(1)	7204743	56	16	56	12	14	9	9	12	12	0	0.104	1.000	1.000
456	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1)	1840976	12	2	12	7	3	4	4	0	1	0	0.838	1.000	1.000
457	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT1(2), AKT2(1), AKT3(1), APAF1(3), ATM(8), BAD(1), BIRC2(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CSF2RB(2), DFFB(1), FAS(2), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IL3RA(1), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	11522105	85	21	83	21	23	18	11	12	21	0	0.0877	1.000	1.000
458	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	32	ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CAPNS2(1), CRKL(2), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9), VCL(1), ZYX(1)	5779443	52	13	52	12	18	14	7	5	8	0	0.0318	1.000	1.000
459	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), PDE6B(3), PDE6C(1), SLC6A13(1)	4559553	34	10	30	12	10	5	7	2	10	0	0.693	1.000	1.000
460	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NR1I3(1), PDE3A(8), PDE3B(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1), VASP(1)	6640031	52	20	47	17	12	9	9	4	18	0	0.569	1.000	1.000
461	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(1), ADORA2A(1), ADRA1A(2), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CHML(3), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(2), GPR50(1), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LHCGR(1), MC3R(3), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPY1R(2), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), RRH(1), SSTR1(4), SSTR4(3), SUCNR1(1), TBXA2R(2), TRHR(1)	16675825	155	37	151	40	45	21	48	28	13	0	0.00605	1.000	1.000
462	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(1), POLG(4), RRM1(1)	1787566	14	3	14	3	3	6	1	1	3	0	0.126	1.000	1.000
463	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(1), CSK(1), DAG1(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(5), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPRC(2), SHC1(1), SOS2(1), SYK(2), VAV1(4)	9604136	83	23	78	20	23	17	11	9	22	1	0.0471	1.000	1.000
464	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	243	ACVR1B(2), AMH(1), AMHR2(5), BMP2(2), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CD40(1), CSF1(2), CSF1R(4), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CL1(1), CXCL16(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPO(1), EPOR(2), FAS(2), FASLG(1), FLT1(3), FLT3(3), FLT4(9), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1RAP(2), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(1), INHBC(1), KDR(1), KIT(4), LEPR(5), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(2), PDGFC(2), PDGFRA(3), PDGFRB(4), PF4V1(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB1(1), TGFB2(2), TGFBR2(5), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(1), TNFSF12(1), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(4), TSLP(1), VEGFB(1), XCR1(2)	23934981	207	48	202	41	57	48	34	39	29	0	8.21e-06	1.000	1.000
465	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(1), AKT1(2), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(2), EDN1(3), ELSPBP1(2), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MYH2(3), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	7037646	61	16	59	15	19	11	10	7	14	0	0.0760	1.000	1.000
466	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(7), ABL2(3), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), BTC(1), CAMK2D(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EGF(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GSK3B(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), NCK1(3), NCK2(2), NRG1(5), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SRC(2), STAT5A(1)	13796211	122	34	119	27	36	23	17	12	34	0	0.0218	1.000	1.000
467	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	20	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMD1(2), PSMD11(1), PSMD12(2)	2044758	12	3	12	6	3	1	4	3	1	0	0.845	1.000	1.000
468	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), AFMID(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(3), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2)	8366147	66	12	65	13	23	11	18	7	7	0	0.0207	1.000	1.000
469	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD81(1), CHUK(1), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), LILRB3(1), MALT1(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(1), SYK(2), VAV1(4)	9563938	84	20	82	24	22	20	11	11	19	1	0.118	1.000	1.000
470	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	APAF1(3), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CRADD(2), DAXX(4), DFFB(1), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(4), PAK2(3), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(4), RASA1(1), RB1(3), RELA(1), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	9264991	68	14	67	19	13	10	19	10	16	0	0.361	1.000	1.000
471	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB2(1), JAK2(2), TYK2(2)	2048364	11	3	11	4	2	1	2	3	3	0	0.697	1.000	1.000
472	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1)	2025420	10	1	10	2	1	1	4	1	3	0	0.459	1.000	1.000
473	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SYK(2), VAV1(4)	4921177	34	6	33	12	9	8	3	6	7	1	0.487	1.000	1.000
474	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(2), AKT2(1), AKT3(1), CASP8(2), CCL3(1), CD14(2), CD40(1), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(1), LBP(1), LY96(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(2), TLR3(2), TLR4(1), TLR5(2), TLR6(3), TLR7(1), TLR8(1), TLR9(5), TOLLIP(1)	12291460	94	25	93	27	21	18	19	14	22	0	0.136	1.000	1.000
475	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), APOA5(3), AQP7(4), CPT1B(4), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(1), CYP7A1(2), CYP8B1(1), EHHADH(1), FABP4(1), GK2(4), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(4), PLTP(1), PPARA(1), PPARD(1), PPARG(1), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(1), SORBS1(1), UCP1(1)	8814334	68	14	67	16	21	18	15	5	8	1	0.0216	1.000	1.000
476	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	28	ARHGAP4(1), ARHGAP5(3), ARHGAP6(3), ARHGEF1(4), ARHGEF11(4), ARHGEF5(2), ARPC1A(1), ARPC2(1), ARPC3(1), BAIAP2(3), DIAPH1(4), LIMK1(1), MYLK(8), PIP5K1B(2), ROCK1(3), SRC(2), TLN1(9), VCL(1)	5886957	53	12	53	17	14	16	10	7	6	0	0.270	1.000	1.000
477	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(7), ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), ATM(8), ATR(9), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CREBBP(2), CUL1(1), E2F3(3), EP300(4), ESPL1(5), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(2), SMAD3(1), SMC1A(1), SMC1B(2), TGFB1(1), TGFB2(2), YWHAE(2), YWHAH(1)	18405172	130	33	127	28	29	25	29	20	26	1	0.0258	1.000	1.000
478	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1)	2142667	7	2	7	3	1	2	3	1	0	0	0.799	1.000	1.000
479	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), EHHADH(1), HADHA(1), SCP2(1)	2317433	10	1	10	0	4	3	2	0	1	0	0.0319	1.000	1.000
480	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(1), CAD(5), CTPS2(1), DPYD(3), DUT(1), NME1(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), RRM1(1), TYMS(1), UMPS(2), UPB1(2)	7899426	52	8	52	15	17	13	10	7	5	0	0.124	1.000	1.000
481	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CITED2(1), CPT1B(4), CREBBP(2), DUT(1), EHHADH(1), EP300(4), HSD17B4(3), LPL(2), ME1(2), NCOR1(7), NCOR2(4), NFKBIA(2), NR1H3(3), NRIP1(1), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTGS2(1), RB1(3), RELA(1), SP1(1), STAT5A(1)	8802872	56	12	56	18	15	15	10	8	8	0	0.221	1.000	1.000
482	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2)	2326713	18	2	18	2	6	4	4	1	3	0	0.0546	1.000	1.000
483	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1)	2519690	12	2	12	5	0	4	5	2	1	0	0.801	1.000	1.000
484	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TRAF2(1)	2576464	12	2	12	4	1	2	4	3	2	0	0.713	1.000	1.000
485	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(1), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(4), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1)	7570823	63	12	61	21	16	14	15	7	11	0	0.394	1.000	1.000
486	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1B(2), ACVR1C(1), ACVRL1(1), AMH(1), AMHR2(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(4), CREBBP(2), CUL1(1), DCN(1), E2F4(4), E2F5(3), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), RBL1(1), RBL2(2), RHOA(1), ROCK1(3), ROCK2(1), RPS6KB2(2), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR2(5), THBS2(4), ZFYVE16(4), ZFYVE9(3)	12834158	92	19	91	24	21	19	18	17	17	0	0.134	1.000	1.000
487	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), ETV5(1), IL12B(1), IL12RB2(1), JAK2(2), MAP2K6(2), MAPK8(2), TYK2(2)	2590830	12	3	12	4	3	1	2	2	4	0	0.511	1.000	1.000
488	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(1), DHCR7(1), FDFT1(2), GGCX(1), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1), VKORC1(3)	2597411	17	4	17	8	4	4	7	1	1	0	0.735	1.000	1.000
489	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ENPP3(2), ENTPD2(2), FHIT(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NPR1(2), NPR2(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(3), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(5), PKLR(2), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1)	17892163	136	25	136	30	48	33	23	13	17	2	0.000946	1.000	1.000
490	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	BAD(1), CABIN1(4), CAMK4(2), CD3E(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(4), FCER1A(1), FOSL1(1), GATA3(2), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(2), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PPP3CC(2), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4)	11980428	83	18	82	22	26	18	12	9	17	1	0.0700	1.000	1.000
491	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(1), EPO(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), STAT5A(1)	2626903	16	3	16	3	6	1	4	2	3	0	0.215	1.000	1.000
492	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(4), ABCA10(3), ABCA12(12), ABCA13(9), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(5), ABCA8(6), ABCA9(7), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(4), ABCB5(6), ABCB6(2), ABCC10(3), ABCC11(2), ABCC12(3), ABCC3(4), ABCC4(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(2), ABCD1(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(4), TAP1(1), TAP2(1)	16010028	131	26	127	35	27	30	20	31	20	3	0.0310	1.000	1.000
493	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	52	ASH1L(4), ASH2L(2), CARM1(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(4), EZH2(3), FBXO11(1), HCFC1(3), HSF4(1), KDM6A(3), MEN1(3), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(4), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SETD2(6), SETD8(1), SETDB1(2), STK38(2), SUV39H2(2), SUV420H1(3), SUV420H2(2), SUZ12(1), WHSC1(1)	15621364	74	22	70	21	10	13	16	15	20	0	0.465	1.000	1.000
494	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), STAT5A(1), SYK(2)	2918940	16	4	16	9	8	3	1	2	2	0	0.800	1.000	1.000
495	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GLCE(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(3), NDST4(2)	2925902	30	6	30	7	12	4	9	3	2	0	0.128	1.000	1.000
496	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(2), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	3128781	16	5	16	6	4	3	5	2	2	0	0.628	1.000	1.000
497	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	3253773	15	3	15	8	2	2	7	3	1	0	0.937	1.000	1.000
498	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	232	ADORA1(1), ADORA2A(1), ADRA1A(2), ADRA2A(1), ADRA2B(4), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CCKAR(6), CCKBR(3), CGA(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHB(1), FSHR(2), GABBR2(1), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GABRB1(3), GABRB2(2), GABRB3(3), GABRD(5), GABRE(2), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(1), GLRA2(3), GLRB(1), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(3), GRIA4(1), GRID1(6), GRID2(4), GRIK1(1), GRIK2(4), GRIK3(3), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRIN3A(4), GRIN3B(2), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM6(6), GRM7(5), GRM8(3), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LEPR(5), LHB(1), LHCGR(1), LTB4R2(1), MC2R(2), MC3R(3), MC5R(2), MCHR1(1), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR2(1), NPY1R(2), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PRLR(3), PRSS1(3), PTGDR(2), PTGER3(1), PTGFR(1), RXFP1(1), SSTR1(4), SSTR4(3), SSTR5(4), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), THRA(2), THRB(1), TRHR(1), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	29887485	318	53	311	87	98	53	73	49	44	1	0.000457	1.000	1.000
499	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AK3(1), CAD(5), CTPS2(1), DPYD(3), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), NME1(1), NME4(1), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2)	10978889	69	15	68	23	18	12	14	19	6	0	0.382	1.000	1.000
500	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	63	A2M(1), C1QA(1), C1QC(1), C1R(1), C1S(4), C3(6), C3AR1(2), C5(1), C5AR1(1), C6(6), C7(4), C8A(5), C9(1), CD46(1), CD55(1), CD59(2), CFB(6), CFD(1), CFH(4), CR1(3), F10(4), F12(2), F13A1(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(3), PLAT(2), PROC(1), PROS1(1), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(3), THBD(3), VWF(5)	11814989	112	26	107	32	27	18	26	20	21	0	0.211	1.000	1.000
501	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(3), CCND2(2), CCND3(1), CDC42(1), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), CRK(1), CRKL(2), CTNNB1(8), DIAPH1(4), DOCK1(2), EGF(2), EGFR(2), ERBB2(6), FARP2(1), FLNA(8), FLNB(3), FLNC(9), FLT1(3), FN1(8), GSK3B(1), HRAS(1), IBSP(2), IGF1R(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KDR(1), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYLK(8), MYLK2(3), MYLPF(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RELN(7), RHOA(1), ROCK1(3), ROCK2(1), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SRC(2), THBS2(4), TLN1(9), TLN2(7), TNC(10), TNN(2), TNR(9), TNXB(8), VASP(1), VAV1(4), VCL(1), VEGFB(1), VTN(2), VWF(5), ZYX(1)	49912723	413	68	405	121	111	86	75	65	71	5	0.0108	1.000	1.000
502	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	CHAD(1), COL11A1(5), COL11A2(3), COL17A1(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), DES(1), DSC1(4), DSC2(5), DSC3(5), DSG1(2), DSG2(2), DSG4(5), FN1(8), GJA3(1), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(1), GJC2(2), GJC3(2), GJD4(2), IBSP(2), INA(3), ITGB4(7), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT15(4), KRT16(1), KRT19(1), KRT2(3), KRT20(2), KRT27(1), KRT28(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(2), KRT7(3), KRT74(2), KRT75(1), KRT76(4), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(6), PRPH(1), RELN(7), THBS2(4), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5)	33599907	307	63	303	94	93	51	57	48	54	4	0.0712	1.000	1.000
503	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	235	ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(1), AKT3(1), ARRB1(1), ARRB2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(1), CACNG3(2), CACNG5(4), CD14(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP16(1), DUSP6(2), DUSP7(1), EGF(2), EGFR(2), FAS(2), FASLG(1), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FLNA(8), FLNB(3), FLNC(9), HRAS(1), IKBKB(2), IL1B(1), JUND(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MOS(1), MRAS(2), NF1(2), NFATC2(5), NFATC4(4), NFKB2(1), NLK(1), NR4A1(3), NTRK1(2), NTRK2(3), PAK2(3), PDGFRA(3), PDGFRB(4), PLA2G3(2), PLA2G6(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTPN5(1), PTPN7(1), RAC2(1), RAP1B(2), RAPGEF2(4), RASA1(1), RASA2(1), RASGRF2(4), RASGRP1(2), RASGRP2(1), RASGRP3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS2(1), SRF(1), STK4(2), STMN1(1), TAOK1(2), TGFB1(1), TGFB2(2), TGFBR2(5), TNFRSF1A(2), TRAF2(1)	38260666	288	53	280	101	91	46	46	44	57	4	0.331	1.000	1.000
504	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	195	ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(5), APC2(2), ARAF(2), ARHGEF1(4), ARHGEF12(4), ARHGEF6(1), ARHGEF7(3), ARPC1A(1), ARPC2(1), ARPC3(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BRAF(3), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(4), DIAPH2(1), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FN1(8), GIT1(4), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LIMK1(1), LIMK2(2), MOS(1), MRAS(2), MYH14(4), MYH9(2), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(4), PXN(1), RAC2(1), RDX(3), RHOA(1), ROCK1(3), ROCK2(1), SCIN(1), SOS2(1), SSH1(3), SSH2(1), SSH3(1), TIAM1(6), TIAM2(1), VAV1(4), VCL(1), WASF1(1), WASF2(2), WASL(5)	36793289	272	53	265	93	70	55	50	36	59	2	0.355	1.000	1.000
505	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	80	AGRN(2), CD44(3), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), DAG1(2), FN1(8), FNDC1(6), FNDC3A(1), GP5(2), GP6(2), GP9(2), HSPG2(2), IBSP(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), RELN(7), SDC3(1), SDC4(2), SV2C(1), THBS2(4), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5)	29999578	245	52	241	77	63	48	52	39	39	4	0.139	1.000	1.000
506	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	163	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY7(3), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(2), ATP2A1(3), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B4(1), AVPR1B(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(6), CCKBR(3), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GNA11(2), GNA14(1), GNA15(2), GNAQ(1), GRIN2A(6), GRIN2C(5), GRIN2D(5), GRM5(7), GRPR(1), HRH2(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), LHCGR(1), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), P2RX2(1), P2RX7(1), PDE1B(1), PDGFRA(3), PDGFRB(4), PHKA2(2), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PPID(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(18), RYR2(10), RYR3(17), SLC25A4(1), SLC8A1(1), SLC8A2(3), SLC8A3(2), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(3)	36151204	351	50	341	111	116	53	75	54	50	3	0.0228	1.000	1.000
507	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	119	ABL1(7), ABLIM1(5), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(3), EFNA1(1), EPHA1(3), EPHA2(4), EPHA3(1), EPHA4(2), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(8), EPHB2(3), EPHB3(3), EPHB4(5), EPHB6(5), GNAI1(1), GNAI2(2), GSK3B(1), HRAS(1), L1CAM(1), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NRP1(2), NTN4(1), NTNG1(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(1), PPP3CA(1), PPP3CC(2), PTK2(4), RAC2(1), RASA1(1), RGS3(1), RHOA(1), RHOD(1), RND1(1), ROBO1(6), ROBO2(3), ROBO3(5), ROCK1(3), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(5), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(3), SEMA4G(2), SEMA5A(4), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(5), SLIT2(4), SLIT3(6), SRGAP1(5), SRGAP2(2), SRGAP3(7), UNC5B(2), UNC5C(4)	26144030	251	50	244	84	81	44	40	39	46	1	0.204	1.000	1.000
508	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADRA1A(2), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(5), ATP2B2(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1S(4), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(1), PLCB3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SLC8A3(2), YWHAH(1)	25047928	224	44	216	83	83	38	40	25	35	3	0.260	1.000	1.000
509	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(5), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(2), CSNK1A1L(3), CSNK1E(1), CSNK2A1(1), CTBP2(5), CTNNB1(8), CUL1(1), DAAM1(7), DAAM2(5), DKK2(1), DKK4(1), DVL1(4), DVL2(3), EP300(4), FBXW11(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), LEF1(3), LRP5(6), LRP6(4), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP3CA(1), PPP3CC(2), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(3), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD3(1), SOX17(1), TCF7(2), TCF7L1(3), TCF7L2(1), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2)	21887692	203	44	198	59	63	36	26	40	38	0	0.0353	1.000	1.000
510	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(4), ACTA2(2), ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF4(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(3), DGKZ(3), ETS2(2), GABPA(2), GBA2(2), GNAQ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(1), ITPR1(6), ITPR2(9), ITPR3(8), MAFF(2), MIB1(1), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), PDE4D(3), PLCB3(4), PLCG1(1), PLCG2(6), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SP1(1), TNXB(8), YWHAH(1)	23945909	206	43	198	70	68	32	39	26	39	2	0.213	1.000	1.000
511	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(4), ACACB(9), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), CALML3(2), CALML6(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EXOC7(1), FASN(7), FBP2(1), FLOT1(1), FLOT2(2), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), GYS2(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS2(3), IRS4(3), LIPE(1), MAPK10(1), MAPK8(2), MAPK9(1), PCK1(3), PCK2(4), PDE3A(8), PDE3B(1), PFKL(2), PFKM(2), PHKA2(2), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAG3(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PYGB(2), PYGM(1), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOCS4(2), SORBS1(1), SOS2(1), SREBF1(1), TRIP10(2), TSC1(1), TSC2(6)	21317648	167	42	164	60	51	39	16	18	41	2	0.283	1.000	1.000
512	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTTN(1), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(2), HRAS(1), IGSF5(1), JAM2(1), LLGL1(5), LLGL2(2), MAGI1(2), MAGI2(7), MAGI3(1), MLLT4(4), MPDZ(2), MRAS(2), MYH1(5), MYH11(5), MYH13(2), MYH14(4), MYH15(6), MYH2(3), MYH3(1), MYH4(5), MYH6(6), MYH7(6), MYH7B(8), MYH8(4), MYH9(2), MYLPF(1), PARD3(6), PARD6A(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP2R3A(5), PPP2R3B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PTEN(2), RAB13(1), RHOA(1), SPTAN1(3), SRC(2), SYMPK(7), TJP1(4), TJP2(5), TJP3(4), YES1(1)	26037646	206	40	204	61	61	40	34	35	36	0	0.0706	1.000	1.000
513	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALML3(2), CALML6(1), CDIPT(2), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPP5D(1), INPP5E(1), INPPL1(5), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PRKCG(2), PTEN(2), SYNJ2(2)	17295099	139	37	132	40	43	22	18	22	34	0	0.0965	1.000	1.000
514	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(2), AKT2(1), AKT3(1), CBL(4), CBLB(1), CCND2(2), CCND3(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(4), EPO(1), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(5), LIF(2), LIFR(5), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRLR(3), PTPN6(4), SOCS4(2), SOCS5(2), SOCS7(1), SOS2(1), SPRED1(1), SPRED2(1), STAM(5), STAM2(1), STAT1(1), STAT2(1), STAT3(2), STAT5A(1), STAT6(4), TPO(4), TSLP(1), TYK2(2)	19308639	149	36	145	42	42	30	22	27	28	0	0.0668	1.000	1.000
515	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(2), BRAF(3), CACNA1A(7), GNA11(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GRIA1(3), GRID2(4), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), IGF1R(3), ITPR1(6), ITPR2(9), ITPR3(8), NOS1(7), NOS3(6), NPR1(2), NPR2(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(18)	14736857	132	36	128	36	47	13	30	21	21	0	0.135	1.000	1.000
516	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ENPP3(2), ENTPD2(2), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GMPR(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NME4(1), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(3), PAICS(2), PAPSS1(3), PAPSS2(3), PDE10A(6), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(1), PFAS(5), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(6)	22583683	166	35	164	43	54	31	27	33	19	2	0.0140	1.000	1.000
517	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	CADM1(1), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(4), CDH2(4), CDH4(3), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(4), CNTN2(1), CNTNAP1(1), CNTNAP2(7), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(2), NFASC(3), NLGN1(4), NLGN2(2), NLGN3(5), NRCAM(1), NRXN1(2), NRXN2(5), NRXN3(4), PDCD1(1), PTPRC(2), PTPRM(6), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELP(3), SIGLEC1(9), VCAN(10)	19545961	164	35	164	58	49	35	34	22	24	0	0.128	1.000	1.000
518	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(7), MYBPC1(5), MYBPC3(3), MYH3(1), MYH6(6), MYH7(6), MYH8(4), MYL1(1), MYL3(1), MYOM1(3), NEB(14), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(3), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(88)	18946046	164	34	162	48	41	41	37	23	20	2	0.265	1.000	1.000
519	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(4), ADCY8(3), ARAF(2), ATF4(1), BRAF(3), CACNA1C(7), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(2), EP300(4), GNAQ(1), GRIA1(3), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRM5(7), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), RAP1B(2), RAPGEF3(3), RPS6KA1(2), RPS6KA2(1)	13360998	115	33	111	35	36	18	17	15	27	2	0.255	1.000	1.000
520	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(7), ACTN1(1), AKT1(2), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(3), BCAR1(2), BRAF(3), CDC42(1), CRK(1), CSE1L(2), DOCK1(2), EPHB2(3), GRB7(5), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGB3BP(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(6), PTEN(2), PTK2(4), ROCK1(3), ROCK2(1), SHC1(1), SOS2(1), SRC(2), TERF2IP(1), TLN1(9), TLN2(7), VASP(1), ZYX(1)	16341917	136	33	130	40	35	28	22	22	29	0	0.160	1.000	1.000
521	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(2), BRAF(3), FAS(2), FASLG(1), FCGR3B(1), HLA-A(4), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), ITGAL(3), ITGB2(1), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), ZAP70(5)	14379958	113	30	110	33	36	22	11	17	26	1	0.0944	1.000	1.000
522	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CALML3(2), CALML6(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(2), CTNNB1(8), DCT(5), DVL1(4), DVL2(3), EDN1(3), EDNRB(2), EP300(4), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GSK3B(1), HRAS(1), KIT(4), LEF1(3), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACG(2), PRKCG(2), TCF7(2), TCF7L1(3), TCF7L2(1), TYR(3), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2)	15009165	144	29	141	49	56	25	17	21	25	0	0.0968	1.000	1.000
523	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	87	AKT1(2), AKT3(1), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(3), CAPN5(2), CAPN6(2), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), MAP2K6(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(4), PXN(1), RAC2(1), RAP1B(2), ROCK1(3), ROCK2(1), SDCCAG8(1), SEPP1(1), SHC1(1), SORBS1(1), SRC(2), TLN1(9), TNS1(4), VASP(1), VCL(1), ZYX(1)	18109981	127	29	125	41	31	31	29	14	22	0	0.150	1.000	1.000
524	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(3), BUB1(1), CDIPT(2), CDKL1(1), CLK1(3), CLK2(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(3), MOS(1), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(2), PRKG1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), STK11(2)	15355170	116	29	114	37	44	17	12	19	24	0	0.274	1.000	1.000
525	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	57	AKT1(2), AKT2(1), AKT3(1), BAD(1), CDC42(1), CREB1(2), ERBB4(6), F2RL2(2), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(5), IRS2(3), IRS4(3), MET(4), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTEN(2), PTK2(4), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1), TSC1(1), TSC2(6), YWHAE(2), YWHAH(1)	9562124	83	29	80	29	18	13	15	13	24	0	0.608	1.000	1.000
526	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(2), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(4), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(3), RAPGEF4(3), RASSF5(1), RHOA(1), RHOH(1), ROCK1(3), ROCK2(1), SIPA1(4), THY1(1), VASP(1), VAV1(4), VCL(1)	17399019	135	28	134	47	46	29	15	21	22	2	0.218	1.000	1.000
527	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ATF4(1), CACNA1C(7), CACNA1F(1), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), LHB(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP2(2), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(3), PRKACG(2), SOS2(1), SRC(2)	16218517	130	26	126	43	39	24	22	17	26	2	0.212	1.000	1.000
528	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CLK2(1), CLK3(3), CLK4(1), COL2A1(4), CPSF1(3), CPSF2(4), CPSF4(1), CSTF1(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(3), DHX16(4), DHX38(1), DHX8(1), DICER1(7), FUS(2), METTL3(1), NCBP2(1), NONO(1), PABPN1(2), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(3), PRPF8(4), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B1(1), SF3B2(1), SF3B5(1), SNRPB(1), SNRPE(2), SNRPN(3), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF2(2), XRN2(3)	14018926	87	26	85	25	26	11	14	17	19	0	0.392	1.000	1.000
529	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT5(2), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHST2(2), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), XYLT1(4), XYLT2(4)	15318073	109	25	107	35	36	17	26	16	14	0	0.211	1.000	1.000
530	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(2), AKT2(1), AKT3(1), CARD11(3), CBL(4), CBLB(1), CD3E(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), CTLA4(1), GRAP2(2), HRAS(1), IKBKB(2), ITK(1), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS2(1), TEC(2), VAV1(4), ZAP70(5)	12927112	108	25	106	30	30	25	14	14	24	1	0.0869	1.000	1.000
531	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	INPP4A(1), INPP4B(1), INPP5A(1), INPP5E(1), INPPL1(5), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PTEN(2), SYNJ2(2)	10206678	71	24	69	27	15	13	11	14	18	0	0.597	1.000	1.000
532	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(1), DHH(2), FBXW11(1), GLI1(5), GLI2(2), GLI3(8), GSK3B(1), HHIP(4), LRP2(3), PRKACG(2), PTCH1(4), PTCH2(6), SMO(2), STK36(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2), ZIC2(4)	8457489	78	24	76	30	31	15	14	6	12	0	0.481	1.000	1.000
533	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(2), AKT2(1), AKT3(1), BRD4(5), CBL(4), CDC42(1), F2RL2(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPPL1(5), IRS2(3), IRS4(3), LNPEP(2), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SORBS1(1), SOS2(1), YWHAE(2), YWHAH(1)	7515214	60	24	57	21	12	13	8	9	18	0	0.616	1.000	1.000
534	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	73	AGL(3), AMY2A(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX56(2), DHX58(2), ENPP3(2), EP400(7), ERCC2(1), G6PC2(1), GAA(2), GANC(1), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), IFIH1(4), MGAM(1), MOV10L1(5), NUDT8(1), PGM3(1), PYGB(2), PYGM(1), RAD54L(3), RUVBL2(3), SETX(5), SI(3), SKIV2L2(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), UXS1(1)	15691923	99	23	97	45	23	21	19	16	19	1	0.946	1.000	1.000
535	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP11(2), AKAP12(2), AKAP3(2), AKAP4(1), AKAP6(4), AKAP7(2), AKAP9(8), ARHGEF1(4), GNA11(2), GNA14(1), GNA15(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(6), PALM2(2), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PRKD1(2), PRKD3(3), RHOA(1)	15824924	117	21	117	47	41	23	19	18	14	2	0.558	1.000	1.000
536	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(9), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADIPOR1(2), AKT1(2), AKT2(1), AKT3(1), CAMKK1(1), CHUK(1), CPT1B(4), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS2(3), IRS4(3), JAK1(1), JAK2(2), JAK3(3), LEPR(5), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(3), PCK2(4), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(3), PRKCQ(2), RELA(1), SLC2A1(4), STAT3(2), STK11(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2)	11313621	98	21	97	33	28	20	15	13	21	1	0.229	1.000	1.000
537	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREBBP(2), CRKL(2), DAG1(2), EGR3(1), GNAQ(1), MAP1B(4), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SRC(2), TERF2IP(1), TH(1)	7013676	53	21	53	21	15	9	7	7	15	0	0.631	1.000	1.000
538	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(1), ETS2(2), ETV6(3), ETV7(1), FMN2(7), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS2(1)	6941757	63	20	60	27	19	9	14	8	13	0	0.895	1.000	1.000
539	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(2), AKT2(1), AKT3(1), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(4), PXN(1), RAC2(1), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(1), SRC(2)	9641696	88	20	85	33	23	21	15	11	18	0	0.518	1.000	1.000
540	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	BRAF(3), CHUK(1), CREB1(2), DAXX(4), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K9(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(2), MEF2D(1), NFKBIA(2), PAK2(3), RELA(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), RPS6KB2(2), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1)	13055497	85	20	83	36	19	18	19	7	22	0	0.892	1.000	1.000
541	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(1), AKT3(1), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(1), RICTOR(5), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), STK11(2), TSC1(1), TSC2(6), ULK1(2), ULK3(1), VEGFB(1)	7464509	59	17	58	20	16	15	7	5	16	0	0.568	1.000	1.000
542	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	38	ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX56(2), DHFR(1), DHX58(2), EP400(7), ERCC2(1), FPGS(3), GCH1(1), GGH(1), IFIH1(4), MOV10L1(5), NUDT8(1), QDPR(2), RAD54L(3), RUVBL2(3), SETX(5), SKIV2L2(1)	7937775	75	16	72	28	16	16	10	14	18	1	0.684	1.000	1.000
543	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(2), CHAT(3), CHPT1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), ESCO1(3), ETNK2(1), GPAM(3), GPD1(1), GPD2(1), LYPLA2(1), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2), PTDSS1(2), PTDSS2(1), SH3GLB1(1)	9042480	60	15	60	21	21	7	12	10	10	0	0.454	1.000	1.000
544	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(1), AKT3(1), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PRKCE(1), RAC2(1), SOS2(1), SYK(2), VAV1(4)	9244373	70	15	69	27	18	18	9	8	16	1	0.511	1.000	1.000
545	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(1), CBL(4), CFLAR(2), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PTPN6(4), SHC1(1), STAT5A(1), SYK(2)	4265982	32	15	32	13	9	6	5	6	6	0	0.697	1.000	1.000
546	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(3), APH1A(2), CREBBP(2), CTBP2(5), DLL4(1), DTX1(3), DTX2(4), DTX4(1), DVL1(4), DVL2(3), EP300(4), JAG1(2), JAG2(3), LFNG(1), MAML1(2), MAML2(3), NCOR2(4), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RFNG(1), SNW1(1)	9710569	77	14	77	37	26	21	14	9	7	0	0.719	1.000	1.000
547	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BFAR(2), BTK(1), CAD(5), CASP10(2), CASP8(2), DAXX(4), DEDD(1), EGFR(2), EPHB2(3), FAF1(1), FAIM2(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(6), RALBP1(2), ROCK1(3), TPX2(2), TRAF2(1)	9724180	64	14	62	23	12	11	16	12	13	0	0.663	1.000	1.000
548	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	36	AARS(1), CARS2(2), DARS(1), DARS2(1), EARS2(1), EPRS(1), FARS2(2), FARSB(1), GARS(5), HARS2(1), IARS(4), KARS(2), LARS2(2), NARS2(2), PARS2(1), QARS(1), RARS(1), RARS2(3), TARS(2), VARS(2), VARS2(2), WARS(2)	7092698	40	13	39	15	11	7	9	7	6	0	0.680	1.000	1.000
549	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), DRD1(2), DRD3(1), DRD5(2), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1)	3620486	37	13	36	15	11	8	9	6	3	0	0.561	1.000	1.000
550	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(3), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), SHC1(1), SOS2(1), SYK(2), VAV1(4)	6558926	43	13	43	16	15	8	5	7	7	1	0.472	1.000	1.000
551	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	CASP10(2), CASP7(1), CASP8(2), CFLAR(2), DAXX(4), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(7), PTPN13(6), RB1(3), SPTAN1(3)	5369983	44	12	42	14	5	3	11	11	14	0	0.780	1.000	1.000
552	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(3), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(2), RDH11(2), SETDB1(2), SHMT1(1), SHMT2(2), SUV39H2(2)	7620637	51	12	48	19	16	7	13	6	8	1	0.572	1.000	1.000
553	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(8), B3GALT4(1), CDR1(1), DGKI(2), FAU(1), IL6ST(3), RPL11(1), RPL18(2), RPL18A(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL3L(2), RPL4(3), RPL7A(1), RPLP0(1), RPLP2(1), RPS11(2), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1)	7228554	47	12	47	27	12	7	10	6	12	0	0.996	1.000	1.000
554	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), CPT1B(4), DAO(2), DMGDH(3), GARS(5), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(6), SARDH(2), SHMT1(1), SHMT2(2), TARS(2)	5892341	45	11	44	17	17	12	6	5	4	1	0.363	1.000	1.000
555	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHSY1(1), DSE(3), XYLT1(4), XYLT2(4)	2093780	20	11	18	12	8	2	5	1	4	0	0.884	1.000	1.000
556	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	29	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX5(1), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4)	3666126	38	11	38	18	18	3	8	2	6	1	0.825	1.000	1.000
557	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	35	CDK7(1), GTF2E1(1), GTF2E2(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3B(3), POLR3E(3), TAF5(1), TAF6(1), TBP(3)	4589631	30	11	27	12	9	4	7	3	7	0	0.797	1.000	1.000
558	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), BAD(1), BRAF(3), CREB1(2), DUSP6(2), MOS(1), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1)	3753337	15	11	15	12	5	1	2	0	7	0	0.997	1.000	1.000
559	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	38	AGL(3), AMY2A(2), ENPP3(2), GAA(2), GANAB(2), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), MGAM(1), PGM3(1), PYGB(2), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1), UXS1(1)	7383667	41	11	41	18	13	10	9	5	4	0	0.757	1.000	1.000
560	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	27	ARSB(2), ARSE(1), CYP11B1(5), HSD11B1(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1)	3328667	22	10	21	10	6	5	4	2	5	0	0.800	1.000	1.000
561	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(1), CYP4F2(2), DHRS4(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), LTA4H(1), PLA2G3(2), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	5212516	39	10	39	24	14	7	10	2	5	1	0.970	1.000	1.000
562	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1)	4887718	30	10	30	14	10	5	4	2	9	0	0.759	1.000	1.000
563	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(1), DAXX(4), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	6459994	43	10	42	17	11	7	8	8	9	0	0.658	1.000	1.000
564	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	CDC42(1), CREB1(2), DAXX(4), HRAS(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K9(2), MAPKAPK5(1), MEF2A(2), MEF2D(1), RPS6KA5(1), SHC1(1), STAT1(1), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1)	4819416	29	10	27	15	7	1	8	4	9	0	0.969	1.000	1.000
565	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	13	GTF2E1(1), GTF2F1(4), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(2), TBP(3)	3281061	20	10	18	17	4	2	4	1	8	1	1.000	1.000	1.000
566	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(1), AZIN1(1), CRY1(1), DNAJA1(1), ETV6(3), GFRA1(3), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(4), PER2(3), PURA(1), TUBB3(1), UCP3(1), ZFR(1)	4619051	31	9	29	17	9	4	4	7	7	0	0.959	1.000	1.000
567	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CD97(1), CRHR2(1), ELTD1(5), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(6), LPHN3(1), VIPR1(1), VIPR2(1)	3748711	31	9	31	13	6	6	4	10	5	0	0.593	1.000	1.000
568	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), DAO(2), DMGDH(3), GARS(5), GLDC(1), HSD3B7(3), PHGDH(1), RDH11(2), SARDH(2), SHMT1(1), SHMT2(2), TARS(2)	5885557	36	9	35	16	15	9	5	5	1	1	0.587	1.000	1.000
569	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADHA(1), PLOD1(2), PLOD2(2), SHMT1(1), SHMT2(2)	5142488	32	9	29	15	10	5	11	1	4	1	0.791	1.000	1.000
570	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(1), AKT3(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS2(3), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS2(1), STAT6(4)	4461795	32	9	32	14	10	9	3	5	5	0	0.619	1.000	1.000
571	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(5), IARS(4), KARS(2), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2)	4367632	24	8	23	9	7	4	7	5	1	0	0.644	1.000	1.000
572	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), HSD3B7(3), MTMR2(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(2), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1)	5205202	37	8	37	15	12	6	13	4	2	0	0.562	1.000	1.000
573	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	29	AKR1B1(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), HSD3B7(3), LCT(3), MGAM(1), PFKL(2), PFKM(2), PGM3(1), RDH11(2)	4953893	29	8	29	12	13	4	6	2	4	0	0.529	1.000	1.000
574	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(3), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1), UAP1(1)	3977329	28	8	28	13	10	3	8	3	4	0	0.827	1.000	1.000
575	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2)	2891470	20	8	20	11	5	5	2	2	6	0	0.838	1.000	1.000
576	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(1), C6(6), C7(4), ICAM1(2), IL6(1), ITGAL(3), ITGB2(1), SELP(3)	3394873	27	8	27	11	8	7	5	2	5	0	0.547	1.000	1.000
577	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2), SHC1(1)	6738435	41	8	41	15	12	9	7	7	6	0	0.514	1.000	1.000
578	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(1), CDC42(1), CREB1(2), DUSP10(1), MAP2K4(2), MAP2K6(2), MAP3K10(3), MAP3K4(2), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1), SRF(1)	4548905	22	8	22	13	5	3	4	3	7	0	0.943	1.000	1.000
579	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	34	AGT(1), AGTR2(1), CAMK2D(1), GNA11(2), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(2), MYLK(8), PLCG1(1), SHC1(1), STAT1(1), STAT3(2), STAT5A(1)	5155326	29	7	29	12	8	7	6	4	4	0	0.612	1.000	1.000
580	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4)	962323	13	7	11	11	4	4	2	0	3	0	0.941	1.000	1.000
581	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), RELA(1)	3878270	23	7	23	11	5	8	3	3	4	0	0.700	1.000	1.000
582	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(2), CAMK1G(1), FPR1(1), GNA15(2), GNB1(2), HRAS(1), MAP2K6(2), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PLCB1(1), PPP3CA(1), PPP3CC(2), RELA(1)	5188598	37	7	36	16	8	8	10	5	6	0	0.807	1.000	1.000
583	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	22	AKR1B1(1), FBP2(1), GAA(2), GANAB(2), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), LCT(3), MGAM(1), PFKM(2), PGM3(1)	4243195	23	7	23	11	10	2	6	1	4	0	0.711	1.000	1.000
584	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4)	962323	13	7	11	11	4	4	2	0	3	0	0.941	1.000	1.000
585	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(6), ARRB2(2), CALML3(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(1), GUCA1A(1), GUCA1C(1), PDC(1), PRKACG(2), PRKG1(1), PRKG2(1)	3886167	27	7	27	13	12	4	7	2	2	0	0.787	1.000	1.000
586	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(1), SRC(2), STAT3(2)	2135891	21	7	20	12	8	6	4	0	3	0	0.831	1.000	1.000
587	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(1), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PAPSS1(3), PAPSS2(3), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SCLY(2)	3452640	26	6	26	11	6	6	9	2	3	0	0.655	1.000	1.000
588	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(6), REG1A(1), SOAT1(1)	1925859	17	6	16	11	8	3	4	0	2	0	0.911	1.000	1.000
589	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(2), PMM2(1), TPI1(2)	3330512	24	5	24	11	9	4	8	1	2	0	0.611	1.000	1.000
590	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2)	3217607	27	5	27	12	9	4	6	4	4	0	0.799	1.000	1.000
591	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(3), SHC1(1), SRF(1), STAT3(2)	2979431	17	5	17	13	5	2	3	2	5	0	0.985	1.000	1.000
592	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(1), SRC(2)	3438424	17	5	17	12	4	4	3	3	3	0	0.960	1.000	1.000
593	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1)	724490	8	4	8	5	6	1	0	1	0	0	0.877	1.000	1.000
594	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1)	2484628	23	4	23	11	5	6	3	4	5	0	0.683	1.000	1.000
595	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3)	3085250	28	4	28	13	7	8	5	3	5	0	0.594	1.000	1.000
596	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP25(1), SNAP29(3), STX11(1), STX12(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VTI1A(1)	2332365	14	4	14	10	8	0	1	2	3	0	0.939	1.000	1.000
597	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(3), PDHA1(1), SLC18A3(2)	985290	9	3	9	7	4	0	4	1	0	0	0.929	1.000	1.000
598	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(1), EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2D(1), PTK2(4), SHC1(1), SRC(2)	4128919	22	3	22	8	3	4	6	4	5	0	0.627	1.000	1.000
599	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	AHCY(2), AMD1(1), DNMT3A(5), DNMT3B(2), MTR(1), TAT(1)	2779855	12	3	12	13	4	2	3	2	1	0	0.997	1.000	1.000
600	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1), SLC25A11(1)	1282632	9	3	9	5	4	4	0	1	0	0	0.678	1.000	1.000
601	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(5), DNMT3B(2), MTR(1)	2403812	10	3	10	12	4	1	3	2	0	0	0.998	1.000	1.000
602	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(1), RB1(3), SKP2(2)	1187640	11	3	11	5	2	3	3	3	0	0	0.775	1.000	1.000
603	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5R1(1), HRAS(1), KLK2(1), NGFR(1)	926066	4	2	4	4	3	0	1	0	0	0	0.944	1.000	1.000
604	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1), IL6(1), IL9(1)	1360609	4	2	4	3	0	2	1	1	0	0	0.838	1.000	1.000
605	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), NOX1(2), RELA(1), XDH(6)	1378242	10	2	10	6	2	3	3	2	0	0	0.886	1.000	1.000
606	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(1), RB1(3), SKP2(2)	1183936	7	2	7	4	1	1	2	3	0	0	0.907	1.000	1.000
607	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(1), MTNR1B(1), PTGDR(2), PTGFR(1), TBXA2R(2)	1607912	7	2	7	5	2	2	3	0	0	0	0.834	1.000	1.000
608	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	5	UGDH(1), UXS1(1)	534709	2	1	2	2	0	0	1	1	0	0	0.978	1.000	1.000
609	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	15	ACP5(1), ENPP3(2), MTMR2(1), MTMR6(1), PHPT1(1), RFK(1), TYR(3)	1896568	10	1	10	5	3	4	2	1	0	0	0.798	1.000	1.000
610	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	4	AOX1(1), PNPO(1)	564835	2	1	2	4	0	0	2	0	0	0	0.991	1.000	1.000
611	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), SQLE(1)	591668	3	1	3	3	1	1	1	0	0	0	0.922	1.000	1.000
612	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	927392	2	1	2	3	1	1	0	0	0	0	0.942	1.000	1.000
613	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1), UXS1(1)	534709	2	1	2	2	0	0	1	1	0	0	0.978	1.000	1.000
614	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), SQLE(1)	444961	3	1	3	3	1	1	1	0	0	0	0.921	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		68977	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	5		519274	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
