PARADIGM pathway analysis of mRNASeq expression data
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
15 July 2014  |  analyses__2014_07_15
Maintainer Information
Citation Information
Maintained by Dan DiCara (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): PARADIGM pathway analysis of mRNASeq expression data. Broad Institute of MIT and Harvard. doi:10.7908/C17P8X44
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 50 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
IL23-mediated signaling events 41
HIF-1-alpha transcription factor network 32
Signaling mediated by p38-alpha and p38-beta 32
IL4-mediated signaling events 31
p75(NTR)-mediated signaling 27
Signaling events mediated by the Hedgehog family 26
Syndecan-1-mediated signaling events 23
BMP receptor signaling 22
Glypican 1 network 21
Glucocorticoid receptor regulatory network 21
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Significance.Ratio = (Ave.Num.Perturbations)/ (Cohort Size) where Cohort Size is 206 . Pathway is significant if Significance.Ratio > 0.05 .

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway. A pathway is defined as significant (red number in Significance.Ratio column) if the Ave.Num.Perturbationsis > 5% of the cohort size ( 206 ).

Pathway.Name Significance.Ratio Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
IL23-mediated signaling events 0.1990 41 2493 60 -0.67 0.013 1000 -1000 -0.17 -1000
HIF-1-alpha transcription factor network 0.1553 32 2458 76 -0.58 0.02 1000 -1000 -0.17 -1000
Signaling mediated by p38-alpha and p38-beta 0.1553 32 1444 44 -0.23 0.013 1000 -1000 -0.046 -1000
IL4-mediated signaling events 0.1505 31 2845 91 -0.81 0.69 1000 -1000 -0.16 -1000
p75(NTR)-mediated signaling 0.1311 27 3460 125 -0.25 0.034 1000 -1000 -0.1 -1000
Signaling events mediated by the Hedgehog family 0.1262 26 1388 52 -0.29 0.07 1000 -1000 -0.053 -1000
Syndecan-1-mediated signaling events 0.1117 23 793 34 -0.18 0.013 1000 -1000 -0.05 -1000
BMP receptor signaling 0.1068 22 1792 81 -0.26 0.026 1000 -1000 -0.088 -1000
Glypican 1 network 0.1019 21 1043 48 -0.16 0.023 1000 -1000 -0.043 -1000
Glucocorticoid receptor regulatory network 0.1019 21 2494 114 -0.66 0.32 1000 -1000 -0.072 -1000
TCR signaling in naïve CD8+ T cells 0.1019 21 1958 93 -0.16 0.083 1000 -1000 -0.08 -1000
IL12-mediated signaling events 0.0971 20 1814 87 -0.32 0.096 1000 -1000 -0.14 -1000
FOXA2 and FOXA3 transcription factor networks 0.0971 20 939 46 -0.41 0.02 1000 -1000 -0.097 -1000
Glypican 2 network 0.0922 19 76 4 -0.054 -0.039 1000 -1000 -0.019 -1000
Neurotrophic factor-mediated Trk receptor signaling 0.0922 19 2334 120 -0.3 0.21 1000 -1000 -0.07 -1000
Nephrin/Neph1 signaling in the kidney podocyte 0.0874 18 644 34 -0.093 0.013 1000 -1000 -0.059 -1000
Endothelins 0.0874 18 1780 96 -0.2 0.018 1000 -1000 -0.083 -1000
Syndecan-2-mediated signaling events 0.0825 17 1235 69 -0.14 0.018 1000 -1000 -0.028 -1000
amb2 Integrin signaling 0.0825 17 1429 82 -0.17 0.015 1000 -1000 -0.083 -1000
Wnt signaling 0.0825 17 124 7 -0.093 0.01 1000 -1000 -0.029 -1000
BCR signaling pathway 0.0825 17 1766 99 -0.19 0.027 1000 -1000 -0.087 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.0777 16 1124 68 -0.31 0.072 1000 -1000 -0.13 -1000
Syndecan-4-mediated signaling events 0.0777 16 1119 67 -0.17 0.02 1000 -1000 -0.096 -1000
Ephrin A reverse signaling 0.0728 15 108 7 -0.025 0 1000 -1000 -0.019 -1000
Nectin adhesion pathway 0.0728 15 955 63 -0.11 0.023 1000 -1000 -0.072 -1000
Effects of Botulinum toxin 0.0728 15 399 26 -0.16 0.013 1000 -1000 -0.06 -1000
IL27-mediated signaling events 0.0728 15 766 51 -0.15 0.086 1000 -1000 -0.075 -1000
Class IB PI3K non-lipid kinase events 0.0728 15 45 3 -0.031 -1000 1000 -1000 -0.009 -1000
Thromboxane A2 receptor signaling 0.0680 14 1500 105 -0.11 0.029 1000 -1000 -0.064 -1000
Integrins in angiogenesis 0.0680 14 1209 84 -0.19 0.019 1000 -1000 -0.1 -1000
IGF1 pathway 0.0680 14 825 57 -0.12 0.026 1000 -1000 -0.085 -1000
Plasma membrane estrogen receptor signaling 0.0680 14 1229 86 -0.12 0.071 1000 -1000 -0.081 -1000
ErbB4 signaling events 0.0631 13 923 69 -0.18 0.064 1000 -1000 -0.09 -1000
Signaling events regulated by Ret tyrosine kinase 0.0631 13 1128 82 -0.14 0.013 1000 -1000 -0.085 -1000
Ephrin B reverse signaling 0.0631 13 642 48 -0.1 0.057 1000 -1000 -0.063 -1000
EPHB forward signaling 0.0631 13 1120 85 -0.11 0.085 1000 -1000 -0.083 -1000
IL6-mediated signaling events 0.0631 13 991 75 -0.15 0.044 1000 -1000 -0.086 -1000
Osteopontin-mediated events 0.0583 12 457 38 -0.11 0.013 1000 -1000 -0.11 -1000
Noncanonical Wnt signaling pathway 0.0583 12 315 26 -0.093 0.013 1000 -1000 -0.052 -1000
Arf6 signaling events 0.0583 12 751 62 -0.1 0.018 1000 -1000 -0.054 -1000
LPA receptor mediated events 0.0583 12 1270 102 -0.12 0.026 1000 -1000 -0.087 -1000
LPA4-mediated signaling events 0.0534 11 132 12 -0.078 0.018 1000 -1000 -0.024 -1000
Caspase cascade in apoptosis 0.0534 11 849 74 -0.094 0.033 1000 -1000 -0.034 -1000
Coregulation of Androgen receptor activity 0.0534 11 854 76 -0.19 0.025 1000 -1000 -0.044 -1000
Fc-epsilon receptor I signaling in mast cells 0.0534 11 1163 97 -0.14 0.031 1000 -1000 -0.087 -1000
PDGFR-alpha signaling pathway 0.0534 11 486 44 -0.08 0.022 1000 -1000 -0.055 -1000
Reelin signaling pathway 0.0534 11 624 56 -0.12 0.019 1000 -1000 -0.081 -1000
IL1-mediated signaling events 0.0534 11 690 62 -0.18 0.059 1000 -1000 -0.1 -1000
Calcium signaling in the CD4+ TCR pathway 0.0534 11 364 31 -0.22 0.013 1000 -1000 -0.095 -1000
TCGA08_retinoblastoma 0.0534 11 92 8 -0.01 0.017 1000 -1000 -0.018 -1000
S1P5 pathway 0.0485 10 178 17 -0.1 0.079 1000 -1000 -0.039 -1000
Nongenotropic Androgen signaling 0.0485 10 569 52 -0.095 0.016 1000 -1000 -0.046 -1000
EGFR-dependent Endothelin signaling events 0.0485 10 221 21 -0.092 0.019 1000 -1000 -0.066 -1000
Visual signal transduction: Rods 0.0485 10 568 52 -0.18 0.013 1000 -1000 -0.077 -1000
Signaling events mediated by PTP1B 0.0437 9 750 76 -0.18 0.02 1000 -1000 -0.088 -1000
Syndecan-3-mediated signaling events 0.0437 9 319 35 -0.18 0.034 1000 -1000 -0.048 -1000
Regulation of Androgen receptor activity 0.0437 9 634 70 -0.28 0.027 1000 -1000 -0.065 -1000
Sphingosine 1-phosphate (S1P) pathway 0.0388 8 226 28 -0.1 0.032 1000 -1000 -0.036 -1000
Visual signal transduction: Cones 0.0388 8 339 38 -0.064 0.013 1000 -1000 -0.054 -1000
JNK signaling in the CD4+ TCR pathway 0.0388 8 143 17 -0.039 0.013 1000 -1000 -0.043 -1000
Cellular roles of Anthrax toxin 0.0388 8 338 39 -0.078 0.014 1000 -1000 -0.02 -1000
Hedgehog signaling events mediated by Gli proteins 0.0388 8 520 65 -0.35 0.037 1000 -1000 -0.068 -1000
Presenilin action in Notch and Wnt signaling 0.0388 8 494 61 -0.16 0.029 1000 -1000 -0.074 -1000
Canonical Wnt signaling pathway 0.0388 8 454 51 -0.16 0.065 1000 -1000 -0.058 -1000
Angiopoietin receptor Tie2-mediated signaling 0.0388 8 788 88 -0.15 0.032 1000 -1000 -0.12 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 0.0388 8 685 78 -0.067 0.038 1000 -1000 -0.074 -1000
BARD1 signaling events 0.0340 7 408 57 -0.055 0.037 1000 -1000 -0.062 -1000
TRAIL signaling pathway 0.0340 7 363 48 -0.044 0.021 1000 -1000 -0.067 -1000
Signaling mediated by p38-gamma and p38-delta 0.0340 7 108 15 -0.018 0.024 1000 -1000 -0.029 -1000
IL2 signaling events mediated by PI3K 0.0340 7 463 58 -0.066 0.023 1000 -1000 -0.089 -1000
S1P4 pathway 0.0340 7 198 25 -0.1 0.019 1000 -1000 -0.039 -1000
Ras signaling in the CD4+ TCR pathway 0.0340 7 125 17 -0.029 0.022 1000 -1000 -0.045 -1000
Regulation of nuclear SMAD2/3 signaling 0.0291 6 880 136 -0.16 0.054 1000 -1000 -0.079 -1000
a4b1 and a4b7 Integrin signaling 0.0291 6 30 5 -0.009 0.003 1000 -1000 -0.026 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0291 6 529 85 -0.054 0.016 1000 -1000 -0.074 -1000
IFN-gamma pathway 0.0291 6 413 68 -0.13 0.023 1000 -1000 -0.1 -1000
RXR and RAR heterodimerization with other nuclear receptor 0.0291 6 332 52 -0.087 0.033 1000 -1000 -0.038 -1000
S1P1 pathway 0.0291 6 235 36 -0.1 0.013 1000 -1000 -0.061 -1000
FAS signaling pathway (CD95) 0.0291 6 294 47 -0.098 0.015 1000 -1000 -0.045 -1000
IL2 signaling events mediated by STAT5 0.0291 6 136 22 -0.039 0.025 1000 -1000 -0.049 -1000
Regulation of Telomerase 0.0291 6 636 102 -0.13 0.038 1000 -1000 -0.12 -1000
S1P3 pathway 0.0291 6 290 42 -0.063 0.02 1000 -1000 -0.043 -1000
ErbB2/ErbB3 signaling events 0.0243 5 386 65 -0.12 0.022 1000 -1000 -0.056 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 0.0243 5 283 54 -0.078 0.025 1000 -1000 -0.1 -1000
Ceramide signaling pathway 0.0243 5 381 76 -0.12 0.036 1000 -1000 -0.047 -1000
Paxillin-independent events mediated by a4b1 and a4b7 0.0243 5 213 37 -0.052 0.02 1000 -1000 -0.049 -1000
Signaling events mediated by HDAC Class III 0.0243 5 214 40 -0.16 0.02 1000 -1000 -0.045 -1000
Retinoic acid receptors-mediated signaling 0.0243 5 345 58 -0.075 0.026 1000 -1000 -0.069 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0243 5 238 45 -0.078 0.038 1000 -1000 -0.092 -1000
Rapid glucocorticoid signaling 0.0243 5 100 20 -0.045 0.016 1000 -1000 -0.026 -1000
TCGA08_rtk_signaling 0.0194 4 104 26 -0.035 0.038 1000 -1000 -0.019 -1000
Stabilization and expansion of the E-cadherin adherens junction 0.0194 4 344 74 -0.19 0.062 1000 -1000 -0.081 -1000
Class I PI3K signaling events 0.0194 4 346 73 -0.077 0.029 1000 -1000 -0.069 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0194 4 155 33 -0.11 0.03 1000 -1000 -0.045 -1000
PDGFR-beta signaling pathway 0.0194 4 421 97 -0.058 0.035 1000 -1000 -0.077 -1000
p38 MAPK signaling pathway 0.0194 4 208 44 -0.12 0.025 1000 -1000 -0.061 -1000
PLK2 and PLK4 events 0.0146 3 10 3 -0.002 0.013 1000 -1000 -0.017 -1000
Aurora A signaling 0.0146 3 195 60 -0.13 0.038 1000 -1000 -0.047 -1000
EPO signaling pathway 0.0146 3 169 55 -0.028 0.045 1000 -1000 -0.087 -1000
mTOR signaling pathway 0.0146 3 196 53 -0.019 0.022 1000 -1000 -0.06 -1000
TCGA08_p53 0.0146 3 23 7 -0.008 0.013 1000 -1000 -0.013 -1000
Regulation of p38-alpha and p38-beta 0.0146 3 206 54 -0.077 0.033 1000 -1000 -0.058 -1000
Signaling events mediated by VEGFR1 and VEGFR2 0.0146 3 421 125 -0.084 0.05 1000 -1000 -0.094 -1000
Insulin Pathway 0.0146 3 272 74 -0.15 0.027 1000 -1000 -0.089 -1000
VEGFR1 specific signals 0.0146 3 184 56 -0.031 0.03 1000 -1000 -0.057 -1000
Signaling events mediated by PRL 0.0146 3 129 34 -0.11 0.032 1000 -1000 -0.041 -1000
FOXM1 transcription factor network 0.0146 3 190 51 -0.093 0.14 1000 -1000 -0.19 -1000
Canonical NF-kappaB pathway 0.0097 2 85 39 -0.041 0.065 1000 -1000 -0.08 -1000
Signaling events mediated by HDAC Class II 0.0097 2 187 75 -0.084 0.035 1000 -1000 -0.041 -1000
Arf6 downstream pathway 0.0097 2 95 43 -0.029 0.024 1000 -1000 -0.032 -1000
ceramide signaling pathway 0.0097 2 113 49 -0.041 0.031 1000 -1000 -0.047 -1000
HIF-2-alpha transcription factor network 0.0097 2 125 43 -0.092 0.093 1000 -1000 -0.092 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0097 2 227 83 -0.069 0.054 1000 -1000 -0.068 -1000
Paxillin-dependent events mediated by a4b1 0.0097 2 105 36 -0.052 0.027 1000 -1000 -0.065 -1000
E-cadherin signaling in keratinocytes 0.0097 2 89 43 -0.033 0.036 1000 -1000 -0.064 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0049 1 41 23 -0.027 0.038 1000 -1000 -0.049 -1000
Circadian rhythm pathway 0.0049 1 37 22 -0.021 0.041 1000 -1000 -0.05 -1000
Aurora C signaling 0.0049 1 10 7 -0.002 0.016 1000 -1000 -0.027 -1000
Insulin-mediated glucose transport 0.0049 1 47 32 -0.042 0.036 1000 -1000 -0.066 -1000
Class I PI3K signaling events mediated by Akt 0.0049 1 87 68 -0.042 0.043 1000 -1000 -0.046 -1000
Signaling events mediated by HDAC Class I 0.0049 1 165 104 -0.041 0.047 1000 -1000 -0.066 -1000
FoxO family signaling 0.0049 1 103 64 -0.079 0.13 1000 -1000 -0.073 -1000
Atypical NF-kappaB pathway 0.0049 1 61 31 -0.01 0.039 1000 -1000 -0.047 -1000
E-cadherin signaling in the nascent adherens junction 0.0049 1 124 76 -0.032 0.056 1000 -1000 -0.081 -1000
Arf6 trafficking events 0.0049 1 107 71 -0.031 0.041 1000 -1000 -0.07 -1000
Aurora B signaling 0.0049 1 116 67 -0.065 0.034 1000 -1000 -0.069 -1000
PLK1 signaling events 0.0000 0 74 85 -0.011 0.032 1000 -1000 -0.045 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0.0000 0 7 27 -0.001 0.031 1000 -1000 -0.052 -1000
E-cadherin signaling events 0.0000 0 2 5 0.01 0.024 1000 -1000 -0.023 -1000
Arf1 pathway 0.0000 0 37 54 -0.011 0.026 1000 -1000 -0.034 -1000
Alternative NF-kappaB pathway 0.0000 0 4 13 0 0.036 1000 -1000 -0.036 -1000
Total NA 1219 76886 7203 -16 -990 131000 -131000 -8.6 -131000
IL23-mediated signaling events

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.55 0.49 -9999 0 -1.2 64 64
IL23A -0.56 0.5 -9999 0 -1.2 63 63
NF kappa B1 p50/RelA/I kappa B alpha -0.57 0.48 -9999 0 -1.2 69 69
positive regulation of T cell mediated cytotoxicity -0.63 0.58 -9999 0 -1.3 70 70
ITGA3 -0.56 0.5 -9999 0 -1.2 63 63
IL17F -0.38 0.31 -9999 0 -0.73 67 67
IL12B -0.039 0.14 -9999 0 -0.58 13 13
STAT1 (dimer) -0.6 0.55 -9999 0 -1.3 68 68
CD4 -0.54 0.49 -9999 0 -1.1 65 65
IL23 -0.55 0.48 -9999 0 -1.1 65 65
IL23R -0.074 0.073 -9999 0 -10000 0 0
IL1B -0.58 0.53 -9999 0 -1.3 63 63
T-helper cell lineage commitment 0 0 -9999 0 -10000 0 0
IL24 -0.64 0.55 -9999 0 -1.3 75 75
TYK2 -0.005 0.017 -9999 0 -10000 0 0
STAT4 -0.017 0.13 -9999 0 -0.6 10 10
STAT3 0.013 0.001 -9999 0 -10000 0 0
IL18RAP -0.035 0.16 -9999 0 -0.62 15 15
IL12RB1 -0.06 0.18 -9999 0 -0.64 18 18
PIK3CA 0.009 0.044 -9999 0 -0.62 1 1
IL12Rbeta1/TYK2 -0.048 0.14 -9999 0 -0.49 18 18
IL23R/JAK2 -0.095 0.1 -9999 0 -0.52 1 1
positive regulation of chronic inflammatory response -0.63 0.58 -9999 0 -1.3 70 70
natural killer cell activation 0.007 0.007 -9999 0 -10000 0 0
JAK2 -0.008 0.076 -9999 0 -0.61 3 3
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
NFKB1 0.007 0.039 -9999 0 -0.55 1 1
RELA 0.009 0.003 -9999 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.53 0.45 -9999 0 -1.1 65 65
ALOX12B -0.67 0.55 -9999 0 -1.3 85 85
CXCL1 -0.64 0.55 -9999 0 -1.2 83 83
T cell proliferation -0.63 0.58 -9999 0 -1.3 70 70
NFKBIA 0.009 0.003 -9999 0 -10000 0 0
IL17A -0.3 0.25 -9999 0 -0.59 48 48
PI3K -0.6 0.49 -9999 0 -1.2 73 73
IFNG -0.035 0.048 -9999 0 -0.12 35 35
STAT3 (dimer) -0.57 0.46 -9999 0 -1.1 73 73
IL18R1 -0.013 0.12 -9999 0 -0.6 8 8
IL23/IL23R/JAK2/TYK2/SOCS3 -0.31 0.28 -9999 0 -0.78 23 23
IL18/IL18R -0.038 0.17 -9999 0 -0.44 28 28
macrophage activation -0.027 0.016 -9999 0 -0.044 64 64
TNF -0.58 0.52 -9999 0 -1.2 67 67
STAT3/STAT4 -0.59 0.5 -9999 0 -1.2 74 74
STAT4 (dimer) -0.6 0.56 -9999 0 -1.3 70 70
IL18 -0.016 0.13 -9999 0 -0.61 9 9
IL19 -0.61 0.52 -9999 0 -1.2 78 78
STAT5A (dimer) -0.6 0.55 -9999 0 -1.3 68 68
STAT1 0.013 0 -9999 0 -10000 0 0
SOCS3 0.006 0.062 -9999 0 -0.62 2 2
CXCL9 -0.64 0.56 -9999 0 -1.2 81 81
MPO -0.54 0.48 -9999 0 -1.1 63 63
positive regulation of humoral immune response -0.63 0.58 -9999 0 -1.3 70 70
IL23/IL23R/JAK2/TYK2 -0.67 0.66 -9999 0 -1.4 70 70
IL6 -0.58 0.51 -9999 0 -1.2 70 70
STAT5A 0 0.088 -9999 0 -0.62 4 4
IL2 0 0.069 -9999 0 -0.56 3 3
positive regulation of tyrosine phosphorylation of STAT protein 0.007 0.007 -9999 0 -10000 0 0
CD3E -0.56 0.51 -9999 0 -1.2 65 65
keratinocyte proliferation -0.63 0.58 -9999 0 -1.3 70 70
NOS2 -0.64 0.54 -9999 0 -1.2 84 84
HIF-1-alpha transcription factor network

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.44 0.45 -9999 0 -1.1 42 42
HDAC7 0.014 0.001 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.37 0.35 -9999 0 -0.87 45 45
SMAD4 0.005 0.076 -9999 0 -0.62 3 3
ID2 -0.44 0.45 -9999 0 -1.1 45 45
AP1 -0.022 0.13 -9999 0 -0.41 20 20
ABCG2 -0.45 0.46 -9999 0 -1.1 47 47
HIF1A -0.052 0.089 -9999 0 -0.71 2 2
TFF3 -0.57 0.5 -9999 0 -1.2 66 66
GATA2 -0.019 0.14 -9999 0 -0.61 11 11
AKT1 -0.08 0.078 -9999 0 -10000 0 0
response to hypoxia -0.099 0.083 -9999 0 -0.24 7 7
MCL1 -0.44 0.45 -9999 0 -1.1 45 45
NDRG1 -0.46 0.46 -9999 0 -1.2 46 46
SERPINE1 -0.47 0.47 -9999 0 -1.2 46 46
FECH -0.44 0.45 -9999 0 -1.1 44 44
FURIN -0.45 0.45 -9999 0 -1.1 45 45
NCOA2 -0.057 0.2 -9999 0 -0.62 23 23
EP300 -0.12 0.13 -9999 0 -0.33 29 29
HMOX1 -0.44 0.45 -9999 0 -1.1 43 43
BHLHE40 -0.44 0.45 -9999 0 -1.1 44 44
BHLHE41 -0.46 0.47 -9999 0 -1.2 47 47
HIF1A/ARNT/SMAD3/SMAD4/SP1 -0.045 0.083 -9999 0 -0.43 5 5
ENG -0.017 0.095 -9999 0 -0.45 1 1
JUN 0.01 0.044 -9999 0 -0.62 1 1
RORA -0.45 0.46 -9999 0 -1.1 45 45
ABCB1 -0.15 0.28 -9999 0 -1.3 11 11
TFRC -0.44 0.45 -9999 0 -1.1 44 44
CXCR4 -0.46 0.47 -9999 0 -1.2 44 44
TF -0.51 0.48 -9999 0 -1.2 53 53
CITED2 -0.44 0.45 -9999 0 -1.1 44 44
HIF1A/ARNT -0.51 0.53 -9999 0 -1.3 50 50
LDHA -0.053 0.054 -9999 0 -10000 0 0
ETS1 -0.45 0.46 -9999 0 -1.1 44 44
PGK1 -0.44 0.45 -9999 0 -1.1 44 44
NOS2 -0.53 0.48 -9999 0 -1.2 54 54
ITGB2 -0.45 0.47 -9999 0 -1.2 43 43
ALDOA -0.44 0.45 -9999 0 -1.1 44 44
Cbp/p300/CITED2 -0.48 0.48 -9999 0 -1.2 46 46
FOS -0.041 0.17 -9999 0 -0.57 19 19
HK2 -0.44 0.45 -9999 0 -1.1 44 44
SP1 0.019 0.01 -9999 0 -10000 0 0
GCK -0.36 0.46 -9999 0 -1 50 50
HK1 -0.44 0.45 -9999 0 -1.1 44 44
NPM1 -0.44 0.45 -9999 0 -1.1 44 44
EGLN1 -0.44 0.45 -9999 0 -1.1 42 42
CREB1 0.02 0 -9999 0 -10000 0 0
PGM1 -0.44 0.45 -9999 0 -1.1 44 44
SMAD3 0.011 0.044 -9999 0 -0.62 1 1
EDN1 -0.16 0.23 -9999 0 -0.74 12 12
IGFBP1 -0.47 0.46 -9999 0 -1.2 46 46
VEGFA -0.31 0.32 -9999 0 -0.8 25 25
HIF1A/JAB1 -0.028 0.057 -9999 0 -0.53 2 2
CP -0.58 0.5 -9999 0 -1.2 62 62
CXCL12 -0.47 0.47 -9999 0 -1.2 48 48
COPS5 0.013 0.002 -9999 0 -10000 0 0
SMAD3/SMAD4 0.012 0.065 -9999 0 -0.45 4 4
BNIP3 -0.45 0.46 -9999 0 -1.2 43 43
EGLN3 -0.47 0.47 -9999 0 -1.1 50 50
CA9 -0.51 0.49 -9999 0 -1.2 53 53
TERT -0.48 0.47 -9999 0 -1.2 46 46
ENO1 -0.44 0.45 -9999 0 -1.1 44 44
PFKL -0.44 0.45 -9999 0 -1.1 44 44
NCOA1 0.013 0 -9999 0 -10000 0 0
ADM -0.45 0.46 -9999 0 -1.2 44 44
ARNT -0.046 0.06 -9999 0 -10000 0 0
HNF4A -0.094 0.2 -9999 0 -0.56 30 30
ADFP -0.45 0.44 -9999 0 -1.1 46 46
SLC2A1 -0.32 0.33 -9999 0 -0.83 28 28
LEP -0.48 0.46 -9999 0 -1.1 48 48
HIF1A/ARNT/Cbp/p300 -0.39 0.36 -9999 0 -0.9 47 47
EPO -0.27 0.29 -9999 0 -0.91 13 13
CREBBP -0.11 0.13 -9999 0 -0.32 28 28
HIF1A/ARNT/Cbp/p300/HDAC7 -0.37 0.35 -9999 0 -0.87 45 45
PFKFB3 -0.44 0.45 -9999 0 -1.1 43 43
NT5E -0.48 0.48 -9999 0 -1.2 46 46
Signaling mediated by p38-alpha and p38-beta

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.18 0.35 -9999 0 -1.1 21 21
MKNK1 0.013 0 -9999 0 -10000 0 0
MAPK14 -0.08 0.13 -9999 0 -0.3 40 40
ATF2/c-Jun -0.052 0.12 -9999 0 -0.43 7 7
MAPK11 -0.093 0.16 -9999 0 -0.33 44 44
MITF -0.095 0.17 -9999 0 -0.36 46 46
MAPKAPK5 -0.09 0.16 -9999 0 -0.36 44 44
KRT8 -0.15 0.23 -9999 0 -0.43 61 61
MAPKAPK3 0.013 0 -9999 0 -10000 0 0
MAPKAPK2 0.013 0 -9999 0 -10000 0 0
p38alpha-beta/CK2 -0.13 0.21 -9999 0 -0.46 45 45
CEBPB -0.09 0.16 -9999 0 -0.36 44 44
SLC9A1 -0.09 0.16 -9999 0 -0.36 44 44
mol:GDP 0 0 -9999 0 -10000 0 0
ATF2 -0.089 0.16 -9999 0 -0.35 47 47
p38alpha-beta/MNK1 -0.088 0.17 -9999 0 -0.46 12 12
JUN -0.051 0.12 -9999 0 -0.43 7 7
PPARGC1A -0.19 0.25 -9999 0 -0.48 68 68
USF1 -0.09 0.16 -9999 0 -0.36 44 44
RAB5/GDP/GDI1 -0.079 0.1 -9999 0 -0.39 6 6
NOS2 -0.23 0.38 -9999 0 -1 29 29
DDIT3 -0.09 0.16 -9999 0 -0.36 44 44
RAB5A 0.013 0 -9999 0 -10000 0 0
HSPB1 -0.076 0.15 -9999 0 -0.47 11 11
p38alpha-beta/HBP1 -0.088 0.17 -9999 0 -0.36 44 44
CREB1 -0.098 0.18 -9999 0 -0.39 46 46
RAB5/GDP 0.009 0 -9999 0 -10000 0 0
EIF4E -0.071 0.15 -9999 0 -0.51 6 6
RPS6KA4 -0.09 0.16 -9999 0 -0.36 44 44
PLA2G4A -0.12 0.21 -9999 0 -0.52 32 32
GDI1 -0.09 0.16 -9999 0 -0.36 44 44
TP53 -0.12 0.2 -9999 0 -0.44 44 44
RPS6KA5 -0.11 0.19 -9999 0 -0.39 51 51
ESR1 -0.15 0.25 -9999 0 -0.47 58 58
HBP1 0.013 0 -9999 0 -10000 0 0
MEF2C -0.094 0.17 -9999 0 -0.37 44 44
MEF2A -0.094 0.17 -9999 0 -0.36 46 46
EIF4EBP1 -0.098 0.18 -9999 0 -0.39 46 46
KRT19 -0.12 0.2 -9999 0 -0.4 52 52
ELK4 -0.09 0.16 -9999 0 -0.36 44 44
ATF6 -0.09 0.16 -9999 0 -0.36 44 44
ATF1 -0.099 0.18 -9999 0 -0.38 47 47
p38alpha-beta/MAPKAPK2 -0.088 0.17 -9999 0 -0.36 44 44
p38alpha-beta/MAPKAPK3 -0.088 0.17 -9999 0 -0.36 44 44
IL4-mediated signaling events

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.61 0.53 -10000 0 -1.3 61 61
STAT6 (cleaved dimer) -0.64 0.53 -10000 0 -1.2 84 84
IGHG1 -0.2 0.16 -10000 0 -0.43 3 3
IGHG3 -0.59 0.5 -10000 0 -1.1 74 74
AKT1 -0.29 0.3 -10000 0 -0.91 21 21
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.23 0.32 -10000 0 -1.1 16 16
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.31 0.31 -10000 0 -0.95 21 21
THY1 -0.62 0.54 -10000 0 -1.3 63 63
MYB -0.014 0.13 -10000 0 -0.6 9 9
HMGA1 0.013 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.37 0.38 -10000 0 -0.84 47 47
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.3 0.32 -10000 0 -0.99 19 19
SP1 0.018 0.006 -10000 0 -10000 0 0
INPP5D 0.006 0.062 -10000 0 -0.62 2 2
SOCS5 0.027 0.013 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.62 0.53 -10000 0 -1.2 71 71
SOCS1 -0.39 0.32 -10000 0 -0.78 49 49
SOCS3 -0.3 0.3 -10000 0 -0.99 18 18
FCER2 -0.48 0.42 -10000 0 -1 49 49
PARP14 0.01 0.044 -10000 0 -0.62 1 1
CCL17 -0.67 0.59 -10000 0 -1.4 71 71
GRB2 0.013 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.24 0.25 -10000 0 -0.87 14 14
T cell proliferation -0.61 0.56 -10000 0 -1.3 65 65
IL4R/JAK1 -0.62 0.54 -10000 0 -1.3 61 61
EGR2 -0.62 0.54 -10000 0 -1.3 60 60
JAK2 -0.025 0.075 -10000 0 -0.59 3 3
JAK3 0.003 0.094 -10000 0 -0.59 5 5
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
JAK1 0.004 0.011 -10000 0 -10000 0 0
COL1A2 -0.24 0.33 -10000 0 -1.1 18 18
CCL26 -0.68 0.6 -10000 0 -1.4 71 71
IL4R -0.66 0.59 -10000 0 -1.4 61 61
PTPN6 0.027 0.011 -10000 0 -10000 0 0
IL13RA2 -0.64 0.56 -10000 0 -1.3 65 65
IL13RA1 -0.017 0.029 -10000 0 -10000 0 0
IRF4 -0.25 0.46 -10000 0 -1.4 26 26
ARG1 -0.18 0.2 -10000 0 -0.67 19 19
CBL -0.35 0.35 -10000 0 -0.87 35 35
GTF3A 0.019 0.01 -10000 0 -10000 0 0
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
IL13RA1/JAK2 -0.028 0.065 -10000 0 -0.44 3 3
IRF4/BCL6 -0.22 0.42 -10000 0 -1.3 25 25
CD40LG -0.052 0.2 -10000 0 -0.61 23 23
MAPK14 -0.34 0.34 -10000 0 -0.94 29 29
mitosis -0.27 0.28 -10000 0 -0.84 21 21
STAT6 -0.72 0.69 -10000 0 -1.5 69 69
SPI1 -0.01 0.12 -10000 0 -0.62 7 7
RPS6KB1 -0.26 0.26 -10000 0 -0.81 20 20
STAT6 (dimer) -0.72 0.69 -10000 0 -1.5 69 69
STAT6 (dimer)/PARP14 -0.66 0.59 -10000 0 -1.3 69 69
mast cell activation 0.014 0.012 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.3 0.35 -10000 0 -1.1 21 21
FRAP1 -0.29 0.3 -10000 0 -0.91 21 21
LTA -0.63 0.56 -10000 0 -1.3 63 63
FES 0.01 0.044 -10000 0 -0.62 1 1
T-helper 1 cell differentiation 0.69 0.63 1.4 70 -10000 0 70
CCL11 -0.68 0.59 -10000 0 -1.4 73 73
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.3 0.34 -10000 0 -1 20 20
IL2RG -0.034 0.17 -10000 0 -0.58 18 18
IL10 -0.62 0.55 -10000 0 -1.3 63 63
IRS1 -0.012 0.12 -10000 0 -0.61 8 8
IRS2 -0.008 0.11 -10000 0 -0.59 7 7
IL4 -0.14 0.11 -10000 0 -10000 0 0
IL5 -0.61 0.53 -10000 0 -1.3 60 60
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.48 0.38 -10000 0 -0.91 63 63
COL1A1 -0.22 0.26 -10000 0 -1 10 10
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.63 0.57 -10000 0 -1.4 60 60
IL2R gamma/JAK3 -0.026 0.16 -10000 0 -0.5 19 19
TFF3 -0.78 0.64 -10000 0 -1.5 81 81
ALOX15 -0.72 0.61 -10000 0 -1.4 78 78
MYBL1 0.01 0.038 -10000 0 -0.54 1 1
T-helper 2 cell differentiation -0.51 0.43 -10000 0 -0.99 66 66
SHC1 0.013 0 -10000 0 -10000 0 0
CEBPB 0.011 0.019 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.29 0.31 -10000 0 -0.95 19 19
mol:PI-3-4-5-P3 -0.29 0.3 -10000 0 -0.91 21 21
PI3K -0.31 0.33 -10000 0 -1 21 21
DOK2 -0.009 0.12 -10000 0 -0.62 7 7
ETS1 0.013 0.092 -10000 0 -0.56 5 5
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.22 0.24 -10000 0 -0.82 14 14
ITGB3 -0.67 0.58 -10000 0 -1.4 68 68
PIGR -0.81 0.63 -10000 0 -1.4 89 89
IGHE 0.044 0.04 -10000 0 -10000 0 0
MAPKKK cascade -0.22 0.23 -10000 0 -0.8 14 14
BCL6 0.013 0.002 -10000 0 -10000 0 0
OPRM1 -0.61 0.52 -10000 0 -1.3 61 61
RETNLB -0.61 0.52 -10000 0 -1.3 62 62
SELP -0.7 0.61 -10000 0 -1.4 72 72
AICDA -0.59 0.5 -10000 0 -1.2 63 63
p75(NTR)-mediated signaling

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.007 0.073 -9999 0 -0.46 5 5
Necdin/E2F1 0.006 0.076 -9999 0 -0.43 6 6
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E -0.16 0.22 -9999 0 -0.62 22 22
NGF (dimer)/p75(NTR)/BEX1 -0.18 0.24 -9999 0 -0.46 66 66
NT-4/5 (dimer)/p75(NTR) -0.17 0.27 -9999 0 -0.5 76 76
IKBKB 0.013 0 -9999 0 -10000 0 0
AKT1 -0.13 0.2 -9999 0 -0.54 19 19
IKBKG 0.013 0 -9999 0 -10000 0 0
BDNF -0.12 0.24 -9999 0 -0.57 45 45
MGDIs/NGR/p75(NTR)/LINGO1 -0.11 0.2 -9999 0 -0.38 69 69
FURIN -0.002 0.093 -9999 0 -0.59 5 5
proBDNF (dimer)/p75(NTR)/Sortilin -0.17 0.22 -9999 0 -0.39 97 97
LINGO1 -0.029 0.15 -9999 0 -0.56 15 15
Sortilin/TRAF6/NRIF -0.009 0.048 -9999 0 -10000 0 0
proBDNF (dimer) -0.12 0.24 -9999 0 -0.57 45 45
NTRK1 -0.021 0.14 -9999 0 -0.6 11 11
RTN4R 0.013 0 -9999 0 -10000 0 0
neuron apoptosis -0.14 0.2 -9999 0 -0.55 18 18
IRAK1 0.013 0 -9999 0 -10000 0 0
SHC1 -0.15 0.22 -9999 0 -0.39 88 88
ARHGDIA 0.013 0 -9999 0 -10000 0 0
RhoA/GTP 0.009 0 -9999 0 -10000 0 0
Gamma Secretase 0.034 0.035 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 -0.15 0.22 -9999 0 -0.41 60 60
MAGEH1 -0.002 0.095 -9999 0 -0.61 5 5
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.15 0.22 -9999 0 -0.42 59 59
Mammalian IAPs/DIABLO -0.011 0.14 -9999 0 -0.48 12 12
proNGF (dimer) -0.1 0.23 -9999 0 -0.56 40 40
MAGED1 -0.006 0.11 -9999 0 -0.62 6 6
APP 0.013 0 -9999 0 -10000 0 0
NT-4/5 (dimer) -0.083 0.23 -9999 0 -0.62 31 31
ZNF274 0.013 0 -9999 0 -10000 0 0
RhoA/GDP/RHOGDI -0.12 0.19 -9999 0 -0.37 54 54
NGF -0.1 0.23 -9999 0 -0.56 40 40
cell cycle arrest -0.14 0.19 -9999 0 -0.53 15 15
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK -0.079 0.14 -9999 0 -0.4 10 10
NT-4/5 (dimer)/p75(NTR)/TRAF6 -0.14 0.24 -9999 0 -0.43 76 76
NCSTN 0.01 0.044 -9999 0 -0.62 1 1
mol:GTP -0.16 0.22 -9999 0 -0.39 90 90
PSENEN 0.013 0 -9999 0 -10000 0 0
mol:ceramide -0.14 0.2 -9999 0 -0.39 59 59
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.056 0.12 -9999 0 -0.42 6 6
p75(NTR)/beta APP -0.11 0.2 -9999 0 -0.43 58 58
BEX1 -0.036 0.15 -9999 0 -0.55 17 17
mol:GDP -0.16 0.22 -9999 0 -0.4 88 88
NGF (dimer) -0.16 0.22 -9999 0 -0.47 49 49
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI -0.091 0.18 -9999 0 -0.37 42 42
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
RAC1/GTP -0.13 0.19 -9999 0 -0.34 88 88
MYD88 0.013 0 -9999 0 -10000 0 0
CHUK 0.013 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/PKA -0.16 0.22 -9999 0 -0.39 90 90
RHOB 0.002 0.076 -9999 0 -0.54 4 4
RHOA 0.013 0 -9999 0 -10000 0 0
MAGE-G1/E2F1 0.017 0.033 -9999 0 -0.46 1 1
NT3 (dimer) -0.1 0.23 -9999 0 -0.57 41 41
TP53 -0.12 0.19 -9999 0 -0.57 12 12
PRDM4 -0.14 0.2 -9999 0 -0.39 59 59
BDNF (dimer) -0.25 0.28 -9999 0 -0.45 110 110
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
SORT1 -0.003 0.098 -9999 0 -0.62 5 5
activation of caspase activity -0.17 0.21 -9999 0 -0.61 22 22
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.14 0.2 -9999 0 -0.39 59 59
RHOC 0.013 0 -9999 0 -10000 0 0
XIAP 0.013 0 -9999 0 -10000 0 0
MAPK10 -0.16 0.2 -9999 0 -0.54 24 24
DIABLO 0.013 0 -9999 0 -10000 0 0
SMPD2 -0.14 0.2 -9999 0 -0.4 59 59
APH1B 0.013 0 -9999 0 -10000 0 0
APH1A 0.013 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin -0.16 0.22 -9999 0 -0.39 92 92
PSEN1 0.01 0.044 -9999 0 -0.62 1 1
APAF-1/Pro-Caspase 9 0.017 0.033 -9999 0 -0.46 1 1
NT3 (dimer)/p75(NTR) -0.19 0.25 -9999 0 -0.47 88 88
MAPK8 -0.14 0.2 -9999 0 -0.51 23 23
MAPK9 -0.13 0.19 -9999 0 -0.51 19 19
APAF1 0.01 0.044 -9999 0 -0.62 1 1
NTF3 -0.1 0.24 -9999 0 -0.57 41 41
NTF4 -0.083 0.23 -9999 0 -0.62 31 31
NDN -0.005 0.1 -9999 0 -0.6 6 6
RAC1/GDP 0.009 0 -9999 0 -10000 0 0
RhoA-B-C/GDP -0.13 0.16 -9999 0 -0.53 11 11
p75 CTF/Sortilin/TRAF6/NRIF 0.015 0.081 -9999 0 -0.34 10 10
RhoA-B-C/GTP -0.17 0.2 -9999 0 -0.39 90 90
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.13 0.2 -9999 0 -0.58 12 12
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.15 0.21 -9999 0 -0.4 58 58
PRKACB 0.006 0.062 -9999 0 -0.62 2 2
proBDNF (dimer)/p75 ECD -0.086 0.19 -9999 0 -0.42 49 49
ChemicalAbstracts:86-01-1 0 0 -9999 0 -10000 0 0
BIRC3 -0.038 0.16 -9999 0 -0.56 18 18
BIRC2 -0.014 0.12 -9999 0 -0.54 10 10
neuron projection morphogenesis -0.15 0.2 -9999 0 -0.41 54 54
BAD -0.14 0.19 -9999 0 -0.5 24 24
RIPK2 0.013 0 -9999 0 -10000 0 0
NGFR -0.16 0.27 -9999 0 -0.6 58 58
CYCS -0.14 0.2 -9999 0 -0.59 14 14
ADAM17 -0.003 0.098 -9999 0 -0.62 5 5
NGF (dimer)/p75(NTR)/TRAF6/RIP2 -0.13 0.2 -9999 0 -0.39 54 54
BCL2L11 -0.14 0.19 -9999 0 -0.49 24 24
BDNF (dimer)/p75(NTR) -0.2 0.25 -9999 0 -0.46 93 93
PI3K -0.14 0.22 -9999 0 -0.42 55 55
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 -0.14 0.2 -9999 0 -0.39 60 60
NDNL2 0.01 0.044 -9999 0 -0.62 1 1
YWHAE 0.013 0 -9999 0 -10000 0 0
PRKCI 0.01 0.038 -9999 0 -0.54 1 1
NGF (dimer)/p75(NTR) -0.19 0.25 -9999 0 -0.46 88 88
ChemicalAbstracts:146-91-8 0 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE -0.15 0.21 -9999 0 -0.41 62 62
TRAF6 0.013 0 -9999 0 -10000 0 0
RAC1 0.013 0 -9999 0 -10000 0 0
PRKCZ 0.013 0 -9999 0 -10000 0 0
PLG -0.017 0.098 -9999 0 -0.54 7 7
oligodendrocyte cell fate commitment 0 0 -9999 0 -10000 0 0
CASP6 -0.19 0.22 -9999 0 -0.46 59 59
SQSTM1 0.01 0.044 -9999 0 -0.62 1 1
NGFRAP1 -0.043 0.18 -9999 0 -0.62 18 18
CASP3 -0.13 0.18 -9999 0 -0.45 24 24
E2F1 0.013 0 -9999 0 -10000 0 0
CASP9 0.013 0 -9999 0 -10000 0 0
IKK complex -0.096 0.13 -9999 0 -0.47 10 10
NGF (dimer)/TRKA -0.088 0.19 -9999 0 -0.42 50 50
MMP7 -0.17 0.28 -9999 0 -0.58 64 64
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.12 0.19 -9999 0 -0.58 11 11
MMP3 -0.14 0.26 -9999 0 -0.59 53 53
APAF-1/Caspase 9 -0.14 0.16 -9999 0 -0.52 19 19
Signaling events mediated by the Hedgehog family

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 -0.21 0.34 -10000 0 -0.69 54 54
IHH -0.1 0.2 -10000 0 -0.57 30 30
SHH Np/Cholesterol/GAS1 -0.065 0.17 -10000 0 -0.35 47 47
LRPAP1 0.013 0 -10000 0 -10000 0 0
dorsoventral neural tube patterning 0.065 0.16 0.35 47 -10000 0 47
SMO/beta Arrestin2 -0.14 0.23 -10000 0 -0.59 27 27
SMO -0.15 0.24 -10000 0 -0.59 33 33
AKT1 -0.062 0.13 -10000 0 -0.45 8 8
ARRB2 0.013 0 -10000 0 -10000 0 0
BOC -0.051 0.18 -10000 0 -0.56 23 23
ADRBK1 0.013 0 -10000 0 -10000 0 0
heart looping -0.15 0.23 -10000 0 -0.57 34 34
STIL -0.13 0.22 -10000 0 -0.55 33 33
DHH N/PTCH2 -0.024 0.14 -10000 0 -0.44 19 19
DHH N/PTCH1 -0.12 0.21 -10000 0 -0.56 24 24
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
DHH -0.009 0.11 -10000 0 -0.59 7 7
PTHLH -0.29 0.45 -10000 0 -0.98 51 51
determination of left/right symmetry -0.15 0.23 -10000 0 -0.57 34 34
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
skeletal system development -0.29 0.44 -10000 0 -0.97 51 51
IHH N/Hhip -0.095 0.2 -10000 0 -0.47 41 41
DHH N/Hhip -0.043 0.16 -10000 0 -0.43 27 27
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.15 0.23 -10000 0 -0.57 34 34
pancreas development -0.052 0.17 -10000 0 -0.54 23 23
HHAT 0.003 0.076 -10000 0 -0.62 3 3
PI3K 0 0.089 -10000 0 -0.42 9 9
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.048 0.18 -10000 0 -0.58 21 21
somite specification -0.15 0.23 -10000 0 -0.57 34 34
SHH Np/Cholesterol/PTCH1 -0.14 0.24 -10000 0 -0.58 34 34
SHH Np/Cholesterol/PTCH2 -0.053 0.15 -10000 0 -0.34 41 41
SHH Np/Cholesterol/Megalin -0.069 0.16 -10000 0 -0.34 49 49
SHH -0.05 0.16 -10000 0 -0.41 32 32
catabolic process -0.13 0.22 -10000 0 -0.58 26 26
SMO/Vitamin D3 -0.15 0.24 -10000 0 -0.63 30 30
SHH Np/Cholesterol/Hhip -0.07 0.16 -10000 0 -0.36 46 46
LRP2 -0.052 0.17 -10000 0 -0.54 23 23
receptor-mediated endocytosis -0.16 0.23 -10000 0 -0.59 33 33
SHH Np/Cholesterol/BOC -0.068 0.15 -10000 0 -0.32 53 53
SHH Np/Cholesterol/CDO -0.037 0.13 -10000 0 -0.32 34 34
mesenchymal cell differentiation 0.07 0.16 0.36 46 -10000 0 46
mol:Vitamin D3 -0.14 0.24 -10000 0 -0.58 34 34
IHH N/PTCH2 -0.076 0.18 -10000 0 -0.42 38 38
CDON 0.004 0.073 -10000 0 -0.6 3 3
IHH N/PTCH1 -0.14 0.22 -10000 0 -0.59 26 26
Megalin/LRPAP1 -0.028 0.13 -10000 0 -0.39 23 23
PTCH2 -0.025 0.14 -10000 0 -0.58 13 13
SHH Np/Cholesterol -0.046 0.12 -10000 0 -0.32 32 32
PTCH1 -0.13 0.22 -10000 0 -0.58 26 26
HHIP -0.052 0.17 -10000 0 -0.54 23 23
Syndecan-1-mediated signaling events

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.003 0.098 -9999 0 -0.62 5 5
CCL5 -0.042 0.17 -9999 0 -0.58 19 19
SDCBP 0.013 0 -9999 0 -10000 0 0
FGFR/FGF2/Syndecan-1 -0.15 0.22 -9999 0 -0.53 36 36
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
Syndecan-1/Laminin-5 -0.14 0.22 -9999 0 -0.54 32 32
Syndecan-1/Syntenin -0.14 0.22 -9999 0 -0.54 31 31
MAPK3 -0.12 0.2 -9999 0 -0.53 24 24
HGF/MET -0.037 0.15 -9999 0 -0.44 25 25
TGFB1/TGF beta receptor Type II -0.003 0.098 -9999 0 -0.62 5 5
BSG 0.013 0 -9999 0 -10000 0 0
keratinocyte migration -0.14 0.21 -9999 0 -0.53 32 32
Syndecan-1/RANTES -0.17 0.24 -9999 0 -0.57 38 38
Syndecan-1/CD147 -0.13 0.21 -9999 0 -0.52 31 31
Syndecan-1/Syntenin/PIP2 -0.14 0.21 -9999 0 -0.53 31 31
LAMA5 0.01 0.044 -9999 0 -0.62 1 1
positive regulation of cell-cell adhesion -0.15 0.19 -9999 0 -0.51 31 31
MMP7 -0.17 0.28 -9999 0 -0.58 64 64
HGF -0.038 0.17 -9999 0 -0.59 17 17
Syndecan-1/CASK -0.15 0.22 -9999 0 -0.51 36 36
Syndecan-1/HGF/MET -0.17 0.23 -9999 0 -0.53 41 41
regulation of cell adhesion -0.1 0.19 -9999 0 -0.52 23 23
HPSE 0.006 0.062 -9999 0 -0.62 2 2
positive regulation of cell migration -0.15 0.22 -9999 0 -0.53 36 36
SDC1 -0.16 0.23 -9999 0 -0.54 36 36
Syndecan-1/Collagen -0.15 0.22 -9999 0 -0.53 36 36
PPIB 0.013 0 -9999 0 -10000 0 0
MET -0.012 0.12 -9999 0 -0.62 8 8
PRKACA 0.013 0 -9999 0 -10000 0 0
MMP9 -0.067 0.2 -9999 0 -0.59 27 27
MAPK1 -0.12 0.2 -9999 0 -0.53 24 24
homophilic cell adhesion -0.15 0.22 -9999 0 -0.53 36 36
MMP1 -0.18 0.28 -9999 0 -0.59 66 66
BMP receptor signaling

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.24 0.27 -9999 0 -0.68 40 40
SMAD6-7/SMURF1 0.016 0.063 -9999 0 -0.38 5 5
NOG -0.071 0.2 -9999 0 -0.56 30 30
SMAD9 -0.066 0.16 -9999 0 -0.58 13 13
SMAD4 0.003 0.076 -9999 0 -0.62 3 3
SMAD5 -0.084 0.16 -9999 0 -0.5 9 9
BMP7/USAG1 -0.26 0.27 -9999 0 -0.48 112 112
SMAD5/SKI -0.073 0.15 -9999 0 -0.47 9 9
SMAD1 0.02 0.043 -9999 0 -0.37 1 1
BMP2 -0.071 0.21 -9999 0 -0.6 28 28
SMAD1/SMAD1/SMAD4 -0.01 0.059 -9999 0 -0.48 1 1
BMPR1A 0.006 0.062 -9999 0 -0.62 2 2
BMPR1B -0.16 0.28 -9999 0 -0.6 59 59
BMPR1A-1B/BAMBI -0.12 0.22 -9999 0 -0.41 67 67
AHSG -0.034 0.15 -9999 0 -0.54 16 16
CER1 -0.005 0.065 -9999 0 -0.54 3 3
BMP2-4/CER1 -0.079 0.18 -9999 0 -0.39 50 50
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.089 0.17 -9999 0 -0.44 23 23
BMP2-4 (homodimer) -0.09 0.2 -9999 0 -0.44 49 49
RGMB 0.013 0 -9999 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B -0.083 0.17 -9999 0 -0.36 44 44
RGMA -0.054 0.19 -9999 0 -0.62 22 22
SMURF1 0.013 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.097 0.16 -9999 0 -0.41 24 24
BMP2-4/USAG1 -0.21 0.23 -9999 0 -0.4 111 111
SMAD6/SMURF1/SMAD5 -0.073 0.15 -9999 0 -0.47 9 9
SOSTDC1 -0.21 0.28 -9999 0 -0.57 78 78
BMP7/BMPR2/BMPR1A-1B -0.16 0.23 -9999 0 -0.41 87 87
SKI 0.013 0 -9999 0 -10000 0 0
BMP6 (homodimer) -0.004 0.095 -9999 0 -0.55 6 6
HFE2 0.001 0.038 -9999 0 -0.54 1 1
ZFYVE16 0.013 0 -9999 0 -10000 0 0
MAP3K7 0.013 0 -9999 0 -10000 0 0
BMP2-4/CHRD -0.12 0.21 -9999 0 -0.4 68 68
SMAD5/SMAD5/SMAD4 -0.078 0.16 -9999 0 -0.48 12 12
MAPK1 0.013 0 -9999 0 -10000 0 0
TAK1/TAB family -0.094 0.12 -9999 0 -0.42 13 13
BMP7 (homodimer) -0.14 0.27 -9999 0 -0.62 51 51
NUP214 0.013 0 -9999 0 -10000 0 0
BMP6/FETUA -0.027 0.13 -9999 0 -0.4 21 21
SMAD1/SKI 0.026 0.042 -9999 0 -0.35 1 1
SMAD6 -0.003 0.098 -9999 0 -0.62 5 5
CTDSP2 0.013 0 -9999 0 -10000 0 0
BMP2-4/FETUA -0.096 0.2 -9999 0 -0.4 58 58
MAP3K7IP1 0 0 -9999 0 -10000 0 0
GREM1 -0.049 0.18 -9999 0 -0.6 21 21
BMPR2 (homodimer) 0.013 0 -9999 0 -10000 0 0
GADD34/PP1CA 0.023 0.034 -9999 0 -0.32 2 2
BMPR1A-1B (homodimer) -0.12 0.21 -9999 0 -0.44 60 60
CHRDL1 -0.14 0.26 -9999 0 -0.59 53 53
ENDOFIN/SMAD1 0.026 0.042 -9999 0 -0.35 1 1
SMAD6-7/SMURF1/SMAD1 -0.01 0.051 -9999 0 -10000 0 0
SMAD6/SMURF1 0.013 0 -9999 0 -10000 0 0
BAMBI -0.032 0.16 -9999 0 -0.6 15 15
SMURF2 0.013 0 -9999 0 -10000 0 0
BMP2-4/CHRDL1 -0.16 0.23 -9999 0 -0.41 89 89
BMP2-4/GREM1 -0.11 0.21 -9999 0 -0.4 63 63
SMAD7 0.013 0 -9999 0 -10000 0 0
SMAD8A/SMAD8A/SMAD4 -0.059 0.16 -9999 0 -0.56 14 14
SMAD1/SMAD6 0.026 0.042 -9999 0 -0.35 1 1
TAK1/SMAD6 0.019 0 -9999 0 -10000 0 0
BMP7 -0.14 0.27 -9999 0 -0.62 51 51
BMP6 -0.004 0.095 -9999 0 -0.55 6 6
MAP3K7IP2 0 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.081 0.15 -9999 0 -0.38 24 24
PPM1A 0.013 0 -9999 0 -10000 0 0
SMAD1/SMURF2 0.026 0.042 -9999 0 -0.35 1 1
SMAD7/SMURF1 0.019 0 -9999 0 -10000 0 0
CTDSPL 0.013 0 -9999 0 -10000 0 0
PPP1CA 0.013 0 -9999 0 -10000 0 0
XIAP 0.013 0 -9999 0 -10000 0 0
CTDSP1 0.013 0 -9999 0 -10000 0 0
PPP1R15A 0.007 0.054 -9999 0 -0.54 2 2
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.17 0.24 -9999 0 -0.58 38 38
CHRD -0.063 0.2 -9999 0 -0.59 26 26
BMPR2 0.013 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.11 0.18 -9999 0 -0.46 24 24
BMP4 -0.052 0.18 -9999 0 -0.56 23 23
FST -0.16 0.27 -9999 0 -0.58 61 61
BMP2-4/NOG -0.12 0.22 -9999 0 -0.42 67 67
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.15 0.22 -9999 0 -0.61 19 19
Glypican 1 network

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer -0.048 0.16 -10000 0 -0.36 40 40
fibroblast growth factor receptor signaling pathway -0.048 0.16 -10000 0 -0.35 40 40
LAMA1 -0.14 0.26 -10000 0 -0.57 55 55
PRNP -0.024 0.15 -10000 0 -0.62 12 12
GPC1/SLIT2 -0.11 0.2 -10000 0 -0.43 59 59
SMAD2 0.023 0.064 -10000 0 -0.51 2 2
GPC1/PrPc/Cu2+ -0.008 0.098 -10000 0 -0.39 13 13
GPC1/Laminin alpha1 -0.098 0.19 -10000 0 -0.41 56 56
TDGF1 -0.058 0.18 -10000 0 -0.54 25 25
CRIPTO/GPC1 -0.035 0.13 -10000 0 -0.39 26 26
APP/GPC1 0.017 0.033 -10000 0 -0.46 1 1
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.02 0.12 -10000 0 -0.32 26 26
FLT1 0.004 0.07 -10000 0 -0.57 3 3
GPC1/TGFB/TGFBR1/TGFBR2 0.019 0.052 -10000 0 -0.35 4 4
SERPINC1 -0.019 0.12 -10000 0 -0.54 11 11
FYN -0.028 0.14 -10000 0 -0.36 28 28
FGR -0.025 0.12 -10000 0 -0.32 29 29
positive regulation of MAPKKK cascade -0.029 0.12 -10000 0 -0.41 8 8
SLIT2 -0.16 0.27 -10000 0 -0.59 58 58
GPC1/NRG -0.078 0.19 -10000 0 -0.44 44 44
NRG1 -0.12 0.25 -10000 0 -0.59 44 44
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.019 0.052 -10000 0 -0.35 4 4
LYN -0.022 0.12 -10000 0 -0.32 27 27
mol:Spermine 0.008 0.033 -10000 0 -0.46 1 1
cell growth -0.048 0.16 -10000 0 -0.35 40 40
BMP signaling pathway -0.01 0.044 0.62 1 -10000 0 1
SRC -0.02 0.12 -10000 0 -0.32 26 26
TGFBR1 0.007 0.054 -10000 0 -0.54 2 2
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.16 0.27 -10000 0 -0.58 60 60
GPC1 0.01 0.044 -10000 0 -0.62 1 1
TGFBR1 (dimer) 0.007 0.054 -10000 0 -0.54 2 2
VEGFA 0.013 0 -10000 0 -10000 0 0
BLK -0.077 0.17 -10000 0 -0.35 55 55
HCK -0.037 0.14 -10000 0 -0.36 33 33
FGF2 -0.041 0.17 -10000 0 -0.57 19 19
FGFR1 -0.049 0.18 -10000 0 -0.56 22 22
VEGFR1 homodimer 0.004 0.07 -10000 0 -0.57 3 3
TGFBR2 0.01 0.044 -10000 0 -0.62 1 1
cell death 0.016 0.033 -10000 0 -0.45 1 1
ATIII/GPC1 -0.006 0.096 -10000 0 -0.39 12 12
PLA2G2A/GPC1 -0.11 0.2 -10000 0 -0.43 60 60
LCK -0.031 0.13 -10000 0 -0.33 32 32
neuron differentiation -0.078 0.19 -10000 0 -0.43 44 44
PrPc/Cu2+ -0.018 0.11 -10000 0 -0.46 12 12
APP 0.013 0 -10000 0 -10000 0 0
TGFBR2 (dimer) 0.01 0.044 -10000 0 -0.62 1 1
Glucocorticoid receptor regulatory network

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.035 0.089 -10000 0 -10000 0 0
SMARCC2 0.013 0.012 -10000 0 -10000 0 0
SMARCC1 0.013 0.012 -10000 0 -10000 0 0
TBX21 -0.14 0.26 -10000 0 -0.71 26 26
SUMO2 0.014 0.008 -10000 0 -10000 0 0
STAT1 (dimer) 0.014 0.047 -10000 0 -0.33 3 3
FKBP4 0.013 0 -10000 0 -10000 0 0
FKBP5 0.01 0.038 -10000 0 -0.54 1 1
GR alpha/HSP90/FKBP51/HSP90 0.12 0.11 0.32 24 -10000 0 24
PRL -0.093 0.13 -10000 0 -0.6 2 2
cortisol/GR alpha (dimer)/TIF2 0.22 0.3 0.58 58 -0.42 3 61
RELA -0.026 0.084 -10000 0 -10000 0 0
FGG 0.19 0.23 0.52 35 -0.48 3 38
GR beta/TIF2 0.074 0.2 0.34 29 -0.39 22 51
IFNG -0.43 0.49 -10000 0 -1 69 69
apoptosis 0.051 0.18 0.48 10 -0.56 2 12
CREB1 -0.002 0.054 -10000 0 -10000 0 0
histone acetylation 0.037 0.16 0.37 10 -0.42 7 17
BGLAP -0.096 0.16 -10000 0 -0.72 3 3
GR/PKAc 0.12 0.11 0.32 19 -0.36 1 20
NF kappa B1 p50/RelA -0.047 0.15 -10000 0 -0.44 8 8
SMARCD1 0.013 0.012 -10000 0 -10000 0 0
MDM2 0.11 0.1 0.28 31 -10000 0 31
GATA3 -0.057 0.2 -10000 0 -0.6 25 25
AKT1 0.001 0.002 -10000 0 -10000 0 0
CSF2 -0.12 0.32 -10000 0 -0.98 19 19
GSK3B 0.014 0.008 -10000 0 -10000 0 0
NR1I3 0.066 0.18 0.48 7 -0.94 2 9
CSN2 0.18 0.17 0.42 37 -0.38 1 38
BRG1/BAF155/BAF170/BAF60A 0.034 0.043 -10000 0 -0.32 2 2
NFATC1 0.007 0.062 -10000 0 -0.62 2 2
POU2F1 0.014 0.014 -10000 0 -10000 0 0
CDKN1A 0.016 0.1 -10000 0 -1.4 1 1
response to stress 0 0 -10000 0 -10000 0 0
response to UV 0.002 0.008 -10000 0 -10000 0 0
SFN -0.042 0.18 -10000 0 -0.62 18 18
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.088 0.14 0.32 17 -10000 0 17
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 0.057 0.19 0.45 9 -0.77 4 13
JUN -0.22 0.23 -10000 0 -0.52 55 55
IL4 -0.12 0.15 -10000 0 -0.51 3 3
CDK5R1 0.002 0.085 -10000 0 -0.6 4 4
PRKACA 0.013 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.16 0.26 0.23 13 -0.53 50 63
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.12 0.11 0.32 24 -10000 0 24
cortisol/GR alpha (monomer) 0.32 0.31 0.69 66 -10000 0 66
NCOA2 -0.058 0.2 -10000 0 -0.62 23 23
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.094 0.18 -10000 0 -0.63 19 19
AP-1/NFAT1-c-4 -0.37 0.37 -10000 0 -0.79 74 74
AFP -0.16 0.19 -10000 0 -0.67 9 9
SUV420H1 0.013 0 -10000 0 -10000 0 0
IRF1 0.16 0.22 0.47 20 -0.82 5 25
TP53 0.028 0.057 -10000 0 -0.55 2 2
PPP5C 0.013 0 -10000 0 -10000 0 0
KRT17 -0.4 0.48 -10000 0 -1.1 55 55
KRT14 -0.66 0.59 -10000 0 -1.2 104 104
TBP 0.018 0.024 -10000 0 -10000 0 0
CREBBP 0.15 0.12 0.31 38 -10000 0 38
HDAC1 0.011 0.011 -10000 0 -10000 0 0
HDAC2 0.021 0.026 -10000 0 -10000 0 0
AP-1 -0.37 0.38 -10000 0 -0.8 75 75
MAPK14 0.014 0.008 -10000 0 -10000 0 0
MAPK10 -0.065 0.2 -10000 0 -0.57 28 28
MAPK11 0.002 0.087 -10000 0 -0.62 4 4
KRT5 -0.51 0.6 -10000 0 -1.2 75 75
interleukin-1 receptor activity 0.008 0.026 -10000 0 -10000 0 0
NCOA1 0.016 0.001 -10000 0 -10000 0 0
STAT1 0.014 0.047 -10000 0 -0.33 3 3
CGA -0.14 0.22 -10000 0 -0.6 27 27
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.22 0.2 0.43 80 -10000 0 80
MAPK3 0.015 0.008 -10000 0 -10000 0 0
MAPK1 0.014 0.008 -10000 0 -10000 0 0
ICAM1 -0.18 0.28 -10000 0 -0.65 37 37
NFKB1 -0.028 0.091 -10000 0 -0.52 1 1
MAPK8 -0.19 0.22 -10000 0 -0.52 48 48
MAPK9 0.014 0.008 -10000 0 -10000 0 0
cortisol/GR alpha (dimer) 0.044 0.18 0.48 10 -0.59 2 12
BAX 0.022 0.04 -10000 0 -10000 0 0
POMC -0.27 0.36 -10000 0 -1 27 27
EP300 0.15 0.13 0.31 43 -0.57 1 44
cortisol/GR alpha (dimer)/p53 0.29 0.26 0.59 65 -0.55 1 66
proteasomal ubiquitin-dependent protein catabolic process 0.078 0.076 0.24 10 -10000 0 10
SGK1 0.19 0.22 0.44 5 -1.2 3 8
IL13 -0.27 0.28 -10000 0 -0.75 35 35
IL6 -0.23 0.35 -10000 0 -0.75 52 52
PRKACG 0.002 0.005 -10000 0 -10000 0 0
IL5 -0.24 0.24 -10000 0 -0.78 15 15
IL2 -0.29 0.28 -10000 0 -0.68 54 54
CDK5 0.014 0.004 -10000 0 -10000 0 0
PRKACB 0.006 0.062 -10000 0 -0.62 2 2
HSP90AA1 0.013 0 -10000 0 -10000 0 0
IL8 -0.27 0.4 -10000 0 -0.9 49 49
CDK5R1/CDK5 0.012 0.064 -10000 0 -0.44 4 4
NF kappa B1 p50/RelA/PKAc -0.017 0.12 -10000 0 -0.47 1 1
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.27 0.23 0.55 63 -10000 0 63
SMARCA4 0.013 0.012 -10000 0 -10000 0 0
chromatin remodeling 0.18 0.16 0.41 42 -10000 0 42
NF kappa B1 p50/RelA/Cbp 0.091 0.18 0.36 21 -0.47 1 22
JUN (dimer) -0.22 0.23 -10000 0 -0.52 55 55
YWHAH 0.013 0 -10000 0 -10000 0 0
VIPR1 -0.12 0.24 -10000 0 -0.69 22 22
NR3C1 0.19 0.2 0.49 42 -0.37 1 43
NR4A1 -0.09 0.19 -10000 0 -0.51 31 31
TIF2/SUV420H1 -0.034 0.15 -10000 0 -0.46 23 23
MAPKKK cascade 0.051 0.18 0.48 10 -0.56 2 12
cortisol/GR alpha (dimer)/Src-1 0.28 0.25 0.58 66 -10000 0 66
PBX1 -0.004 0.11 -10000 0 -0.61 6 6
POU1F1 0.002 0.041 -10000 0 -0.54 1 1
SELE -0.26 0.41 -10000 0 -0.92 46 46
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.18 0.16 0.41 42 -10000 0 42
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.27 0.23 0.55 63 -10000 0 63
mol:cortisol 0.19 0.2 0.39 76 -10000 0 76
MMP1 -0.35 0.49 -10000 0 -1.1 50 50
TCR signaling in naïve CD8+ T cells

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.11 0.22 -10000 0 -0.57 33 33
FYN -0.1 0.34 -10000 0 -0.78 34 34
LAT/GRAP2/SLP76 -0.11 0.25 -10000 0 -0.63 33 33
IKBKB 0.013 0 -10000 0 -10000 0 0
AKT1 -0.043 0.2 -10000 0 -0.46 34 34
B2M 0.003 0.077 -10000 0 -0.63 3 3
IKBKG -0.026 0.048 -10000 0 -0.16 10 10
MAP3K8 0.006 0.062 -10000 0 -0.62 2 2
mol:Ca2+ -0.03 0.042 -10000 0 -0.11 30 30
integrin-mediated signaling pathway 0.009 0.056 -10000 0 -0.39 4 4
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.083 0.31 -10000 0 -0.7 35 35
TRPV6 -0.15 0.27 -10000 0 -0.61 53 53
CD28 -0.02 0.14 -10000 0 -0.6 11 11
SHC1 -0.098 0.32 -10000 0 -0.75 34 34
receptor internalization -0.11 0.35 -10000 0 -0.82 34 34
PRF1 -0.12 0.38 -10000 0 -1.1 22 22
KRAS 0.01 0.038 -10000 0 -0.54 1 1
GRB2 0.013 0 -10000 0 -10000 0 0
COT/AKT1 -0.025 0.16 -10000 0 -0.38 29 29
LAT -0.1 0.33 -10000 0 -0.77 34 34
EntrezGene:6955 0 0.004 -10000 0 -10000 0 0
CD3D -0.052 0.19 -10000 0 -0.6 22 22
CD3E -0.049 0.19 -10000 0 -0.6 21 21
CD3G -0.039 0.17 -10000 0 -0.61 17 17
RASGRP2 -0.003 0.04 -10000 0 -0.15 10 10
RASGRP1 -0.044 0.21 -10000 0 -0.47 31 31
HLA-A -0.006 0.11 -10000 0 -0.63 6 6
RASSF5 0.003 0.076 -10000 0 -0.62 3 3
RAP1A/GTP/RAPL 0.009 0.056 -10000 0 -0.39 4 4
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.01 0.063 -10000 0 -0.13 20 20
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.047 0.087 -10000 0 -0.26 21 21
PRKCA -0.044 0.11 -10000 0 -0.29 26 26
GRAP2 -0.023 0.14 -10000 0 -0.6 12 12
mol:IP3 -0.038 0.21 0.24 40 -0.47 29 69
EntrezGene:6957 0 0.005 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.12 0.38 -10000 0 -0.81 35 35
ORAI1 0.083 0.14 0.32 53 -0.47 1 54
CSK -0.1 0.33 -10000 0 -0.77 34 34
B7 family/CD28 -0.16 0.33 -10000 0 -0.81 35 35
CHUK 0.013 0 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.13 0.4 -10000 0 -0.89 36 36
PTPN6 -0.1 0.33 -10000 0 -0.76 35 35
VAV1 -0.1 0.33 -10000 0 -0.76 35 35
Monovalent TCR/CD3 -0.08 0.29 -10000 0 -0.68 30 30
CBL 0.006 0.062 -10000 0 -0.62 2 2
LCK -0.11 0.36 -10000 0 -0.82 34 34
PAG1 -0.1 0.33 -10000 0 -0.77 34 34
RAP1A 0.01 0.044 -10000 0 -0.62 1 1
TCR/CD3/MHC I/CD8/LCK -0.13 0.39 -10000 0 -0.88 36 36
CD80 -0.021 0.14 -10000 0 -0.62 11 11
CD86 -0.024 0.15 -10000 0 -0.62 12 12
PDK1/CARD11/BCL10/MALT1 -0.058 0.11 -10000 0 -0.32 21 21
HRAS 0.013 0 -10000 0 -10000 0 0
GO:0035030 -0.082 0.27 -10000 0 -0.63 35 35
CD8A -0.063 0.2 -10000 0 -0.59 26 26
CD8B -0.099 0.24 -10000 0 -0.6 38 38
PTPRC -0.039 0.17 -10000 0 -0.61 17 17
PDK1/PKC theta -0.061 0.26 -10000 0 -0.58 34 34
CSK/PAG1 -0.097 0.32 -10000 0 -0.74 34 34
SOS1 0.013 0 -10000 0 -10000 0 0
peptide-MHC class I -0.003 0.099 -10000 0 -0.46 9 9
GRAP2/SLP76 -0.13 0.3 -10000 0 -0.73 35 35
STIM1 0.045 0.07 -10000 0 -10000 0 0
RAS family/GTP 0.008 0.084 -10000 0 -0.18 17 17
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.13 0.4 -10000 0 -0.92 34 34
mol:DAG -0.059 0.17 -10000 0 -0.42 30 30
RAP1A/GDP 0.005 0.029 -10000 0 -0.12 1 1
PLCG1 0.013 0 -10000 0 -10000 0 0
CD247 -0.032 0.16 -10000 0 -0.61 15 15
cytotoxic T cell degranulation -0.11 0.35 -10000 0 -1 22 22
RAP1A/GTP -0.005 0.014 -10000 0 -0.075 6 6
mol:PI-3-4-5-P3 -0.059 0.24 -10000 0 -0.55 35 35
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.063 0.27 0.26 37 -0.63 29 66
NRAS 0.013 0 -10000 0 -10000 0 0
ZAP70 -0.049 0.18 -10000 0 -0.6 21 21
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 -0.1 0.24 -10000 0 -0.6 34 34
MALT1 0.013 0 -10000 0 -10000 0 0
TRAF6 0.013 0 -10000 0 -10000 0 0
CD8 heterodimer -0.11 0.25 -10000 0 -0.52 51 51
CARD11 -0.022 0.14 -10000 0 -0.59 12 12
PRKCB -0.051 0.14 -10000 0 -0.35 29 29
PRKCE -0.041 0.11 -10000 0 -0.29 27 27
PRKCQ -0.08 0.29 -10000 0 -0.68 34 34
LCP2 0.001 0.085 -10000 0 -0.6 4 4
BCL10 0.013 0 -10000 0 -10000 0 0
regulation of survival gene product expression -0.031 0.17 -10000 0 -0.38 34 34
IKK complex 0.018 0.063 -10000 0 -0.12 17 17
RAS family/GDP -0.005 0.01 -10000 0 -10000 0 0
MAP3K14 -0.011 0.13 -10000 0 -0.29 27 27
PDPK1 -0.038 0.2 -10000 0 -0.44 32 32
TCR/CD3/MHC I/CD8/Fyn -0.14 0.41 -10000 0 -0.88 39 39
IL12-mediated signaling events

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.097 0.2 -10000 0 -0.44 31 31
TBX21 -0.23 0.49 -10000 0 -1.2 35 35
B2M 0.002 0.076 -10000 0 -0.62 3 3
TYK2 0.011 0.021 -10000 0 -10000 0 0
IL12RB1 -0.044 0.19 -10000 0 -0.64 18 18
GADD45B -0.17 0.4 -10000 0 -0.95 31 31
IL12RB2 -0.12 0.26 -10000 0 -0.61 45 45
GADD45G -0.2 0.44 -10000 0 -0.98 37 37
natural killer cell activation 0.001 0.023 -10000 0 -10000 0 0
RELB 0.013 0 -10000 0 -10000 0 0
RELA 0.013 0 -10000 0 -10000 0 0
IL18 -0.015 0.13 -10000 0 -0.61 9 9
IL2RA -0.029 0.16 -10000 0 -0.6 14 14
IFNG -0.13 0.26 -10000 0 -0.59 49 49
STAT3 (dimer) -0.17 0.37 -10000 0 -0.85 35 35
HLA-DRB5 -0.074 0.21 -10000 0 -0.58 30 30
FASLG -0.25 0.51 -10000 0 -1.2 37 37
NF kappa B2 p52/RelB -0.27 0.41 -10000 0 -0.97 42 42
CD4 -0.011 0.12 -10000 0 -0.6 8 8
SOCS1 0.005 0.066 -10000 0 -0.54 3 3
EntrezGene:6955 -0.003 0.013 -10000 0 -10000 0 0
CD3D -0.053 0.19 -10000 0 -0.59 22 22
CD3E -0.051 0.18 -10000 0 -0.6 21 21
CD3G -0.04 0.17 -10000 0 -0.61 17 17
IL12Rbeta2/JAK2 -0.088 0.21 -10000 0 -0.46 47 47
CCL3 -0.22 0.47 -10000 0 -1.1 35 35
CCL4 -0.22 0.48 -10000 0 -1.1 34 34
HLA-A -0.007 0.11 -10000 0 -0.62 6 6
IL18/IL18R -0.023 0.18 -10000 0 -0.45 26 26
NOS2 -0.3 0.55 -10000 0 -1.2 51 51
IL12/IL12R/TYK2/JAK2/SPHK2 -0.095 0.2 -10000 0 -0.44 29 29
IL1R1 -0.23 0.48 -10000 0 -1.1 36 36
IL4 0.001 0.023 -10000 0 -10000 0 0
JAK2 0.003 0.074 -10000 0 -0.58 3 3
EntrezGene:6957 -0.003 0.013 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.2 0.51 -10000 0 -1 41 41
RAB7A -0.13 0.34 -10000 0 -0.85 22 22
lysosomal transport -0.12 0.32 -10000 0 -0.79 22 22
FOS -0.18 0.4 -10000 0 -0.98 33 33
STAT4 (dimer) -0.19 0.43 -10000 0 -0.96 36 36
STAT5A (dimer) -0.32 0.45 -10000 0 -1 47 47
GZMA -0.23 0.5 -10000 0 -1.2 37 37
GZMB -0.24 0.53 -10000 0 -1.2 36 36
HLX 0.004 0.07 -10000 0 -0.57 3 3
LCK -0.24 0.52 -10000 0 -1.2 39 39
TCR/CD3/MHC II/CD4 -0.12 0.36 -10000 0 -0.84 31 31
IL2/IL2R -0.048 0.21 -10000 0 -0.6 21 21
MAPK14 -0.18 0.42 -10000 0 -0.94 35 35
CCR5 -0.2 0.47 -10000 0 -1.3 25 25
IL1B -0.061 0.19 -10000 0 -0.56 26 26
STAT6 -0.046 0.15 -10000 0 -0.38 9 9
STAT4 -0.017 0.13 -10000 0 -0.6 10 10
STAT3 0.013 0 -10000 0 -10000 0 0
STAT1 0.013 0 -10000 0 -10000 0 0
NFKB1 0.01 0.038 -10000 0 -0.54 1 1
NFKB2 0.013 0 -10000 0 -10000 0 0
IL12B -0.022 0.14 -10000 0 -0.56 13 13
CD8A -0.065 0.2 -10000 0 -0.6 26 26
CD8B -0.1 0.24 -10000 0 -0.6 38 38
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.096 0.2 0.43 31 -10000 0 31
IL2RB -0.02 0.14 -10000 0 -0.6 11 11
proteasomal ubiquitin-dependent protein catabolic process -0.17 0.38 -10000 0 -0.85 36 36
IL2RG -0.04 0.17 -10000 0 -0.58 18 18
IL12 -0.058 0.18 -10000 0 -0.43 36 36
STAT5A 0 0.088 -10000 0 -0.62 4 4
CD247 -0.034 0.16 -10000 0 -0.61 15 15
IL2 -0.003 0.066 -10000 0 -0.54 3 3
SPHK2 0.013 0 -10000 0 -10000 0 0
FRAP1 0 0 -10000 0 -10000 0 0
IL12A -0.061 0.2 -10000 0 -0.58 25 25
IL12/IL12R/TYK2/JAK2 -0.28 0.62 -10000 0 -1.2 43 43
MAP2K3 -0.18 0.43 -10000 0 -0.93 37 37
RIPK2 0.013 0 -10000 0 -10000 0 0
MAP2K6 -0.19 0.43 -10000 0 -0.93 39 39
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA -0.028 0.15 -10000 0 -0.62 13 13
IL18RAP -0.034 0.16 -10000 0 -0.62 15 15
IL12Rbeta1/TYK2 -0.025 0.15 -10000 0 -0.49 18 18
EOMES -0.12 0.38 -10000 0 -1.3 18 18
STAT1 (dimer) -0.21 0.4 -10000 0 -0.89 41 41
T cell proliferation -0.12 0.31 -10000 0 -0.7 29 29
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 -0.012 0.12 -10000 0 -0.61 8 8
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.21 0.29 -10000 0 -0.74 36 36
ATF2 -0.16 0.38 -10000 0 -0.86 33 33
FOXA2 and FOXA3 transcription factor networks

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.26 0.38 -9999 0 -1.1 23 23
PCK1 -0.26 0.31 -9999 0 -0.95 19 19
HNF4A -0.31 0.45 -9999 0 -1.2 29 29
KCNJ11 -0.32 0.45 -9999 0 -1.1 36 36
AKT1 -0.059 0.12 -9999 0 -0.43 1 1
response to starvation -0.002 0.018 -9999 0 -10000 0 0
DLK1 -0.3 0.42 -9999 0 -1.1 30 30
NKX2-1 -0.14 0.23 -9999 0 -0.67 16 16
ACADM -0.26 0.39 -9999 0 -1.1 25 25
TAT -0.24 0.27 -9999 0 -0.84 19 19
CEBPB 0.013 0.005 -9999 0 -10000 0 0
CEBPA -0.03 0.16 -9999 0 -0.62 14 14
TTR -0.24 0.31 -9999 0 -0.95 25 25
PKLR -0.29 0.4 -9999 0 -1.1 26 26
APOA1 -0.31 0.45 -9999 0 -1.2 28 28
CPT1C -0.28 0.41 -9999 0 -1.1 26 26
ALAS1 -0.097 0.17 -9999 0 -10000 0 0
TFRC -0.28 0.3 -9999 0 -0.8 28 28
FOXF1 0.006 0.081 -9999 0 -0.53 4 4
NF1 0.02 0.001 -9999 0 -10000 0 0
HNF1A (dimer) -0.087 0.2 -9999 0 -0.59 27 27
CPT1A -0.26 0.39 -9999 0 -1.1 22 22
HMGCS1 -0.26 0.38 -9999 0 -1.1 23 23
NR3C1 -0.004 0.092 -9999 0 -0.62 4 4
CPT1B -0.26 0.38 -9999 0 -1 25 25
chromatin remodeling 0 0 -9999 0 -10000 0 0
SP1 -0.012 0.061 -9999 0 -10000 0 0
GCK -0.41 0.48 -9999 0 -1.1 48 48
CREB1 0.007 0.027 -9999 0 -10000 0 0
IGFBP1 -0.13 0.22 -9999 0 -0.71 14 14
PDX1 -0.32 0.5 -9999 0 -1.2 40 40
UCP2 -0.27 0.39 -9999 0 -1.1 26 26
ALDOB -0.3 0.43 -9999 0 -1.1 27 27
AFP -0.15 0.18 -9999 0 -0.57 14 14
BDH1 -0.26 0.38 -9999 0 -1 29 29
HADH -0.27 0.4 -9999 0 -1.1 25 25
F2 -0.3 0.43 -9999 0 -1.2 26 26
HNF1A -0.087 0.21 -9999 0 -0.59 27 27
G6PC -0.14 0.19 -9999 0 -0.59 13 13
SLC2A2 -0.2 0.26 -9999 0 -0.78 16 16
INS -0.015 0.094 -9999 0 -0.58 5 5
FOXA1 -0.027 0.16 -9999 0 -0.62 13 13
FOXA3 -0.27 0.3 -9999 0 -0.59 94 94
FOXA2 -0.32 0.46 -9999 0 -1.1 31 31
ABCC8 -0.29 0.41 -9999 0 -1.1 25 25
ALB -0.15 0.2 -9999 0 -0.65 16 16
Glypican 2 network

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK 0.001 0.085 -9999 0 -0.6 4 4
GPC2 -0.054 0.19 -9999 0 -0.62 22 22
GPC2/Midkine -0.039 0.16 -9999 0 -0.46 25 25
neuron projection morphogenesis -0.039 0.16 -9999 0 -0.46 25 25
Neurotrophic factor-mediated Trk receptor signaling

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.013 0 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 -0.037 0.11 -10000 0 -0.38 4 4
NT3 (dimer)/TRKC -0.11 0.21 -10000 0 -0.45 54 54
NT3 (dimer)/TRKB -0.3 0.28 -10000 0 -0.48 132 132
SHC/Grb2/SOS1/GAB1/PI3K 0.023 0.057 -10000 0 -0.26 6 6
RAPGEF1 0.013 0 -10000 0 -10000 0 0
BDNF -0.12 0.24 -10000 0 -0.57 45 45
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
DYNLT1 0.013 0 -10000 0 -10000 0 0
NTRK1 -0.021 0.14 -10000 0 -0.6 11 11
NTRK2 -0.22 0.29 -10000 0 -0.57 83 83
NTRK3 -0.043 0.17 -10000 0 -0.57 19 19
NT-4/5 (dimer)/TRKB -0.28 0.28 -10000 0 -0.46 130 130
neuron apoptosis 0.21 0.22 0.48 66 -0.22 4 70
SHC 2-3/Grb2 -0.23 0.25 0.23 4 -0.53 66 70
SHC1 0.013 0 -10000 0 -10000 0 0
SHC2 -0.2 0.24 0.22 4 -0.54 48 52
SHC3 -0.21 0.24 0.22 4 -0.51 58 62
STAT3 (dimer) -0.003 0.084 -10000 0 -0.35 7 7
NT3 (dimer)/TRKA -0.18 0.23 -10000 0 -0.41 95 95
RIN/GDP -0.035 0.088 -10000 0 -0.25 4 4
GIPC1 0.013 0 -10000 0 -10000 0 0
KRAS 0.01 0.038 -10000 0 -0.54 1 1
DNAJA3 -0.13 0.18 0.25 5 -0.4 47 52
RIN/GTP 0.002 0.004 -10000 0 -10000 0 0
CCND1 -0.022 0.18 -10000 0 -0.63 16 16
MAGED1 -0.006 0.11 -10000 0 -0.62 6 6
PTPN11 0.013 0 -10000 0 -10000 0 0
RICS 0 0 -10000 0 -10000 0 0
NT-4/5 (dimer) -0.083 0.23 -10000 0 -0.62 31 31
SHC/GRB2/SOS1 0.026 0 -10000 0 -10000 0 0
GRB2 0.013 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK -0.1 0.21 -10000 0 -0.4 63 63
TRKA/NEDD4-2 -0.006 0.1 -10000 0 -0.44 11 11
ELMO1 0.001 0.085 -10000 0 -0.6 4 4
RhoG/GTP/ELMO1/DOCK1 0.006 0.067 -10000 0 -0.38 6 6
NGF -0.1 0.23 -10000 0 -0.56 40 40
HRAS 0.013 0 -10000 0 -10000 0 0
DOCK1 0.006 0.062 -10000 0 -0.62 2 2
GAB2 0.01 0.038 -10000 0 -0.54 1 1
RIT2 0.003 0.005 -10000 0 -10000 0 0
RIT1 0.013 0 -10000 0 -10000 0 0
FRS2 0.013 0 -10000 0 -10000 0 0
DNM1 -0.015 0.13 -10000 0 -0.62 9 9
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.013 0 -10000 0 -10000 0 0
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP -0.13 0.18 0.24 5 -0.39 49 54
mol:GDP -0.053 0.12 -10000 0 -0.36 6 6
NGF (dimer) -0.1 0.23 -10000 0 -0.56 40 40
RhoG/GDP 0.001 0.063 -10000 0 -0.45 4 4
RIT1/GDP -0.031 0.088 -10000 0 -0.25 2 2
TIAM1 -0.03 0.16 -10000 0 -0.62 14 14
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
BDNF (dimer)/TRKB -0.2 0.25 -10000 0 -0.42 103 103
KIDINS220/CRKL/C3G 0.019 0 -10000 0 -10000 0 0
SHC/RasGAP 0.012 0.057 -10000 0 -0.46 3 3
FRS2 family/SHP2 0.026 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1/GAB1 0.029 0.037 -10000 0 -0.34 2 2
RIT1/GTP 0.009 0 -10000 0 -10000 0 0
NT3 (dimer) -0.1 0.23 -10000 0 -0.57 41 41
RAP1/GDP -0.043 0.06 -10000 0 -10000 0 0
KIDINS220/CRKL 0.013 0 -10000 0 -10000 0 0
BDNF (dimer) -0.12 0.24 -10000 0 -0.57 45 45
ubiquitin-dependent protein catabolic process -0.066 0.16 -10000 0 -0.35 50 50
Schwann cell development -0.052 0.036 -10000 0 -10000 0 0
EHD4 0.013 0 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0.033 0 -10000 0 -10000 0 0
FRS2 family/SHP2/CRK family/C3G/GAB2 0.038 0.01 -10000 0 -10000 0 0
RAP1B 0.013 0 -10000 0 -10000 0 0
RAP1A 0.01 0.044 -10000 0 -0.62 1 1
CDC42/GTP -0.26 0.26 -10000 0 -0.59 64 64
ABL1 0.01 0.044 -10000 0 -0.62 1 1
SH2B family/GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
Rap1/GTP -0.068 0.078 -10000 0 -10000 0 0
STAT3 -0.003 0.083 -10000 0 -0.35 7 7
axon guidance -0.25 0.24 -10000 0 -0.56 64 64
MAPK3 -0.088 0.2 -10000 0 -0.45 29 29
MAPK1 -0.088 0.2 -10000 0 -0.45 29 29
CDC42/GDP -0.031 0.088 -10000 0 -0.24 4 4
NTF3 -0.1 0.24 -10000 0 -0.57 41 41
NTF4 -0.083 0.23 -10000 0 -0.62 31 31
NGF (dimer)/TRKA/FAIM -0.066 0.16 -10000 0 -0.35 50 50
PI3K 0 0.089 -10000 0 -0.42 9 9
FRS3 0.013 0 -10000 0 -10000 0 0
FAIM 0.013 0 -10000 0 -10000 0 0
GAB1 0.006 0.062 -10000 0 -0.62 2 2
RASGRF1 -0.18 0.2 0.25 4 -0.42 64 68
SOS1 0.013 0 -10000 0 -10000 0 0
MCF2L -0.12 0.22 -10000 0 -0.4 69 69
RGS19 0.013 0 -10000 0 -10000 0 0
CDC42 0.013 0 -10000 0 -10000 0 0
RAS family/GTP -0.015 0.078 -10000 0 -10000 0 0
Rac1/GDP -0.031 0.088 -10000 0 -0.24 4 4
NGF (dimer)/TRKA/GRIT -0.075 0.16 -10000 0 -0.36 50 50
neuron projection morphogenesis -0.11 0.19 -10000 0 -0.53 16 16
NGF (dimer)/TRKA/NEDD4-2 -0.066 0.16 -10000 0 -0.35 50 50
MAP2K1 0.034 0.034 -10000 0 -0.31 2 2
NGFR -0.16 0.27 -10000 0 -0.6 58 58
NGF (dimer)/TRKA/GIPC/GAIP -0.034 0.12 -10000 0 -0.5 4 4
RAS family/GTP/PI3K 0.019 0.051 -10000 0 -0.27 4 4
FRS2 family/SHP2/GRB2/SOS1 0.038 0 -10000 0 -10000 0 0
NRAS 0.013 0 -10000 0 -10000 0 0
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
PRKCI 0.01 0.038 -10000 0 -0.54 1 1
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCZ 0.013 0 -10000 0 -10000 0 0
MAPKKK cascade -0.12 0.19 -10000 0 -0.64 20 20
RASA1 0.003 0.076 -10000 0 -0.62 3 3
TRKA/c-Abl -0.008 0.11 -10000 0 -0.44 12 12
SQSTM1 0.01 0.044 -10000 0 -0.62 1 1
BDNF (dimer)/TRKB/GIPC -0.18 0.23 -10000 0 -0.47 55 55
NGF (dimer)/TRKA/p62/Atypical PKCs -0.045 0.15 -10000 0 -0.59 3 3
MATK -0.052 0.19 -10000 0 -0.59 22 22
NEDD4L 0.013 0 -10000 0 -10000 0 0
RAS family/GDP -0.039 0.058 -10000 0 -0.24 1 1
NGF (dimer)/TRKA -0.14 0.19 0.27 5 -0.39 60 65
Rac1/GTP -0.13 0.12 -10000 0 -0.33 35 35
FRS2 family/SHP2/CRK family 0.038 0 -10000 0 -10000 0 0
Nephrin/Neph1 signaling in the kidney podocyte

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity 0.091 0.2 0.45 46 -10000 0 46
KIRREL -0.093 0.23 -10000 0 -0.61 34 34
Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.091 0.2 -10000 0 -0.45 46 46
PLCG1 0.013 0 -10000 0 -10000 0 0
ARRB2 0.013 0 -10000 0 -10000 0 0
WASL 0.013 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP -0.074 0.14 -10000 0 -0.38 26 26
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.033 0.12 -10000 0 -0.3 26 26
FYN -0.061 0.15 -10000 0 -0.36 26 26
mol:Ca2+ -0.074 0.14 -10000 0 -0.37 26 26
mol:DAG -0.074 0.14 -10000 0 -0.37 26 26
NPHS2 -0.011 0.025 -10000 0 -10000 0 0
mol:IP3 -0.074 0.14 -10000 0 -0.37 26 26
regulation of endocytosis -0.051 0.14 -10000 0 -0.34 26 26
Nephrin/NEPH1/podocin/Cholesterol -0.076 0.15 -10000 0 -0.34 46 46
establishment of cell polarity -0.091 0.2 -10000 0 -0.45 46 46
Nephrin/NEPH1/podocin/NCK1-2 -0.045 0.14 -10000 0 -0.52 4 4
Nephrin/NEPH1/beta Arrestin2 -0.051 0.14 -10000 0 -0.34 26 26
NPHS1 -0.043 0.14 -10000 0 -0.55 15 15
Nephrin/NEPH1/podocin -0.062 0.15 -10000 0 -0.37 26 26
TJP1 0.013 0 -10000 0 -10000 0 0
NCK1 0.013 0 -10000 0 -10000 0 0
NCK2 0.013 0 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 -0.074 0.14 -10000 0 -0.38 26 26
CD2AP 0.013 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/GRB2 -0.074 0.14 -10000 0 -0.38 26 26
GRB2 0.013 0 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.075 0.16 -10000 0 -0.37 30 30
cytoskeleton organization -0.038 0.14 -10000 0 -0.37 17 17
Nephrin/NEPH1 -0.064 0.14 -10000 0 -0.32 46 46
Nephrin/NEPH1/ZO-1 -0.08 0.15 -10000 0 -0.4 28 28
Endothelins

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.005 0.23 -10000 0 -0.72 11 11
PTK2B 0.013 0.001 -10000 0 -10000 0 0
mol:Ca2+ -0.038 0.25 -10000 0 -0.8 12 12
EDN1 0.017 0.16 -10000 0 -0.5 8 8
EDN3 -0.053 0.17 -10000 0 -0.54 22 22
EDN2 -0.18 0.28 -10000 0 -0.59 64 64
HRAS/GDP -0.034 0.18 -10000 0 -0.52 14 14
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.033 0.18 -10000 0 -0.45 18 18
ADCY4 -0.037 0.22 -10000 0 -0.62 17 17
ADCY5 -0.11 0.27 -10000 0 -0.65 30 30
ADCY6 -0.034 0.22 -10000 0 -0.64 16 16
ADCY7 -0.033 0.21 -10000 0 -0.64 15 15
ADCY1 -0.058 0.23 -10000 0 -0.62 19 19
ADCY2 -0.093 0.26 -10000 0 -0.62 28 28
ADCY3 -0.031 0.21 -10000 0 -0.62 15 15
ADCY8 -0.041 0.21 -10000 0 -0.66 14 14
ADCY9 -0.033 0.21 -10000 0 -0.62 15 15
arachidonic acid secretion -0.056 0.21 -10000 0 -0.51 20 20
ETB receptor/Endothelin-1/Gq/GTP -0.034 0.16 -10000 0 -0.46 15 15
GNAO1 -0.016 0.13 -10000 0 -0.57 10 10
HRAS 0.012 0.003 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP 0.017 0.25 0.32 55 -0.67 11 66
ETA receptor/Endothelin-1/Gs/GTP -0.013 0.26 0.3 50 -0.66 15 65
mol:GTP 0.001 0.004 -10000 0 -10000 0 0
COL3A1 -0.02 0.29 -10000 0 -0.79 20 20
EDNRB -0.013 0.12 -10000 0 -0.6 8 8
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.004 0.25 -10000 0 -0.66 16 16
CYSLTR1 -0.027 0.29 -10000 0 -0.69 24 24
SLC9A1 0.002 0.13 0.2 28 -0.34 10 38
mol:GDP -0.042 0.2 -10000 0 -0.52 17 17
SLC9A3 -0.065 0.23 -10000 0 -0.59 22 22
RAF1 -0.046 0.18 -10000 0 -0.51 15 15
JUN -0.025 0.23 -10000 0 -0.65 14 14
JAK2 0 0.23 -10000 0 -0.72 11 11
mol:IP3 -0.039 0.18 -10000 0 -0.51 15 15
ETA receptor/Endothelin-1 0.012 0.3 0.38 55 -0.78 12 67
PLCB1 -0.046 0.18 -10000 0 -0.62 19 19
PLCB2 0.006 0.058 -10000 0 -0.58 2 2
ETA receptor/Endothelin-3 -0.049 0.2 -10000 0 -0.48 28 28
FOS -0.05 0.24 -10000 0 -0.64 19 19
Gai/GDP -0.029 0.15 -10000 0 -0.67 6 6
CRK 0.013 0.001 -10000 0 -10000 0 0
mol:Ca ++ -0.051 0.26 -10000 0 -0.73 18 18
BCAR1 0.013 0.001 -10000 0 -10000 0 0
PRKCB1 -0.038 0.17 -10000 0 -0.49 15 15
GNAQ 0.01 0.044 -10000 0 -0.62 1 1
GNAZ -0.055 0.19 -10000 0 -0.59 23 23
GNAL -0.045 0.18 -10000 0 -0.58 20 20
Gs family/GDP -0.1 0.16 -10000 0 -0.48 23 23
ETA receptor/Endothelin-1/Gq/GTP -0.025 0.2 -10000 0 -0.51 17 17
MAPK14 -0.03 0.14 -10000 0 -0.5 8 8
TRPC6 -0.042 0.27 -10000 0 -0.86 12 12
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 -0.021 0.14 -10000 0 -0.62 11 11
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.039 0.15 -10000 0 -0.46 12 12
ETB receptor/Endothelin-2 -0.14 0.22 -10000 0 -0.43 71 71
ETB receptor/Endothelin-3 -0.048 0.15 -10000 0 -0.41 29 29
ETB receptor/Endothelin-1 0.003 0.16 -10000 0 -0.45 13 13
MAPK3 -0.049 0.22 -10000 0 -0.64 15 15
MAPK1 -0.049 0.22 -10000 0 -0.64 15 15
Rac1/GDP -0.033 0.18 -10000 0 -0.5 15 15
cAMP biosynthetic process -0.072 0.24 -10000 0 -0.59 25 25
MAPK8 -0.042 0.26 -10000 0 -0.71 18 18
SRC 0.013 0 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP -0.017 0.13 -10000 0 -0.43 9 9
p130Cas/CRK/Src/PYK2 -0.041 0.2 -10000 0 -0.56 15 15
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.033 0.18 -10000 0 -0.51 14 14
COL1A2 -0.033 0.33 -10000 0 -0.82 24 24
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.14 0.25 -10000 0 -0.46 71 71
mol:DAG -0.039 0.18 -10000 0 -0.51 15 15
MAP2K2 -0.044 0.19 -10000 0 -0.51 17 17
MAP2K1 -0.044 0.19 -10000 0 -0.52 16 16
EDNRA -0.001 0.21 -10000 0 -0.72 12 12
positive regulation of muscle contraction 0.011 0.2 -10000 0 -0.63 11 11
Gq family/GDP -0.1 0.18 -10000 0 -0.53 23 23
HRAS/GTP -0.05 0.18 -10000 0 -0.48 19 19
PRKCH -0.031 0.17 -10000 0 -0.51 13 13
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCA -0.036 0.18 -10000 0 -0.49 15 15
PRKCB -0.053 0.2 -10000 0 -0.52 20 20
PRKCE -0.031 0.17 -10000 0 -0.51 13 13
PRKCD -0.031 0.17 -10000 0 -0.51 13 13
PRKCG -0.072 0.2 -10000 0 -0.5 22 22
regulation of vascular smooth muscle contraction -0.059 0.26 -10000 0 -0.8 15 15
PRKCQ -0.063 0.2 -10000 0 -0.5 24 24
PLA2G4A -0.063 0.22 -10000 0 -0.56 20 20
GNA14 -0.062 0.2 -10000 0 -0.56 27 27
GNA15 -0.039 0.17 -10000 0 -0.62 17 17
GNA12 0.013 0 -10000 0 -10000 0 0
GNA11 -0.008 0.12 -10000 0 -0.62 7 7
Rac1/GTP 0.018 0.25 0.32 55 -0.67 11 66
MMP1 -0.2 0.4 -10000 0 -0.74 66 66
Syndecan-2-mediated signaling events

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin -0.062 0.17 -9999 0 -0.37 45 45
EPHB2 -0.024 0.15 -9999 0 -0.62 12 12
Syndecan-2/TACI -0.068 0.17 -9999 0 -0.37 47 47
LAMA1 -0.14 0.26 -9999 0 -0.57 55 55
Syndecan-2/alpha2 ITGB1 -0.041 0.18 -9999 0 -0.45 25 25
HRAS 0.013 0 -9999 0 -10000 0 0
Syndecan-2/CASK -0.009 0.088 -9999 0 -0.34 13 13
ITGA5 -0.01 0.11 -9999 0 -0.57 8 8
BAX 0.001 0.11 -9999 0 -10000 0 0
EPB41 0.01 0.044 -9999 0 -0.62 1 1
positive regulation of cell-cell adhesion 0.001 0.08 -9999 0 -0.3 13 13
LAMA3 -0.043 0.17 -9999 0 -0.59 19 19
EZR 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
CAV2 -0.006 0.11 -9999 0 -0.62 6 6
Syndecan-2/MMP2 -0.017 0.13 -9999 0 -0.39 20 20
RP11-540L11.1 0 0 -9999 0 -10000 0 0
alpha2 ITGB1 -0.02 0.13 -9999 0 -0.46 17 17
dendrite morphogenesis -0.023 0.12 -9999 0 -0.36 25 25
Syndecan-2/GM-CSF -0.056 0.15 -9999 0 -0.34 44 44
determination of left/right symmetry -0.008 0.1 -9999 0 -0.4 13 13
Syndecan-2/PKC delta 0.001 0.088 -9999 0 -0.34 13 13
GNB2L1 0.013 0 -9999 0 -10000 0 0
MAPK3 -0.042 0.14 -9999 0 -0.3 44 44
MAPK1 -0.042 0.14 -9999 0 -0.3 44 44
Syndecan-2/RACK1 0.009 0.076 -9999 0 -0.28 13 13
NF1 0.013 0 -9999 0 -10000 0 0
FGFR/FGF/Syndecan-2 -0.008 0.1 -9999 0 -0.4 13 13
ITGA2 -0.04 0.18 -9999 0 -0.62 17 17
MAPK8 -0.009 0.12 -9999 0 -0.35 22 22
Syndecan-2/alpha2/beta1 Integrin -0.095 0.21 -9999 0 -0.43 40 40
Syndecan-2/Kininogen -0.026 0.12 -9999 0 -0.36 23 23
ITGB1 0.013 0 -9999 0 -10000 0 0
SRC 0.016 0.072 -9999 0 -0.26 13 13
Syndecan-2/CASK/Protein 4.1 -0.001 0.084 -9999 0 -0.31 14 14
extracellular matrix organization -0.009 0.11 -9999 0 -0.35 18 18
actin cytoskeleton reorganization -0.062 0.17 -9999 0 -0.37 45 45
Syndecan-2/Caveolin-2/Ras -0.001 0.1 -9999 0 -0.33 18 18
Syndecan-2/Laminin alpha3 -0.034 0.15 -9999 0 -0.4 28 28
Syndecan-2/RasGAP 0.01 0.082 -9999 0 -0.27 16 16
alpha5/beta1 Integrin 0.002 0.083 -9999 0 -0.41 8 8
PRKCD 0.013 0 -9999 0 -10000 0 0
Syndecan-2 dimer -0.023 0.13 -9999 0 -0.36 25 25
GO:0007205 0.003 0.001 -9999 0 -10000 0 0
DNA mediated transformation 0 0 -9999 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.018 0.08 -9999 0 -0.29 7 7
RHOA 0.013 0 -9999 0 -10000 0 0
SDCBP 0.013 0 -9999 0 -10000 0 0
TNFRSF13B -0.096 0.23 -9999 0 -0.58 37 37
RASA1 0.003 0.076 -9999 0 -0.62 3 3
alpha2/beta1 Integrin -0.02 0.13 -9999 0 -0.46 17 17
Syndecan-2/Synbindin 0.001 0.088 -9999 0 -0.34 13 13
TGFB1 -0.003 0.098 -9999 0 -0.62 5 5
CASP3 0.01 0.08 -9999 0 -0.3 13 13
FN1 -0.089 0.22 -9999 0 -0.57 36 36
Syndecan-2/IL8 -0.072 0.17 -9999 0 -0.36 52 52
SDC2 -0.008 0.1 -9999 0 -0.41 13 13
KNG1 -0.029 0.13 -9999 0 -0.54 12 12
Syndecan-2/Neurofibromin 0.001 0.088 -9999 0 -0.34 13 13
TRAPPC4 0.013 0 -9999 0 -10000 0 0
CSF2 -0.076 0.21 -9999 0 -0.57 31 31
Syndecan-2/TGFB1 -0.009 0.11 -9999 0 -0.35 18 18
Syndecan-2/Syntenin/PI-4-5-P2 0.001 0.08 -9999 0 -0.31 13 13
Syndecan-2/Ezrin 0.009 0.08 -9999 0 -0.3 13 13
PRKACA 0.01 0.08 -9999 0 -0.3 13 13
angiogenesis -0.072 0.17 -9999 0 -0.35 52 52
MMP2 -0.016 0.13 -9999 0 -0.58 10 10
IL8 -0.1 0.24 -9999 0 -0.58 40 40
calcineurin-NFAT signaling pathway -0.067 0.17 -9999 0 -0.37 47 47
amb2 Integrin signaling

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.058 0.15 -9999 0 -0.43 25 25
alphaM/beta2 Integrin/GPIbA -0.056 0.16 -9999 0 -0.48 21 21
alphaM/beta2 Integrin/proMMP-9 -0.088 0.18 -9999 0 -0.43 40 40
PLAUR 0.01 0.038 -9999 0 -0.54 1 1
HMGB1 0.006 0.019 -9999 0 -10000 0 0
alphaM/beta2 Integrin/Talin -0.042 0.13 -9999 0 -0.45 16 16
AGER 0.006 0.019 -9999 0 -10000 0 0
RAP1A 0.01 0.044 -9999 0 -0.62 1 1
SELPLG 0.001 0.085 -9999 0 -0.6 4 4
mol:LDL 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.066 0.14 -9999 0 -0.63 7 7
mol:GTP 0 0 -9999 0 -10000 0 0
MMP9 -0.067 0.2 -9999 0 -0.59 27 27
CYR61 -0.031 0.15 -9999 0 -0.55 16 16
TLN1 0.013 0 -9999 0 -10000 0 0
Rap1/GTP -0.09 0.12 -9999 0 -0.41 14 14
RHOA 0.013 0 -9999 0 -10000 0 0
P-selectin oligomer -0.087 0.23 -9999 0 -0.61 33 33
MYH2 -0.11 0.17 -9999 0 -0.44 26 26
MST1R -0.018 0.14 -9999 0 -0.61 10 10
leukocyte activation during inflammatory response -0.11 0.17 -9999 0 -0.4 35 35
APOB -0.04 0.16 -9999 0 -0.54 18 18
mol:GDP 0 0 -9999 0 -10000 0 0
complement component iC3b receptor activity 0 0 -9999 0 -10000 0 0
MMP2 -0.016 0.13 -9999 0 -0.58 10 10
JAM3 0.007 0.054 -9999 0 -0.54 2 2
GP1BA -0.013 0.12 -9999 0 -0.56 9 9
alphaM/beta2 Integrin/CTGF -0.074 0.16 -9999 0 -0.4 35 35
alphaM/beta2 Integrin -0.096 0.15 -9999 0 -0.4 28 28
JAM3 homodimer 0.007 0.054 -9999 0 -0.54 2 2
ICAM2 -0.004 0.098 -9999 0 -0.57 6 6
ICAM1 -0.005 0.1 -9999 0 -0.61 6 6
phagocytosis triggered by activation of immune response cell surface activating receptor -0.095 0.15 -9999 0 -0.4 28 28
cell adhesion -0.055 0.16 -9999 0 -0.48 21 21
NFKB1 -0.05 0.2 -9999 0 -0.6 15 15
THY1 -0.013 0.12 -9999 0 -0.58 9 9
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
Lipoprotein(a) -0.088 0.17 -9999 0 -0.37 53 53
alphaM/beta2 Integrin/LRP/tPA -0.077 0.19 -9999 0 -0.43 36 36
IL6 -0.09 0.28 -9999 0 -0.74 23 23
ITGB2 -0.021 0.13 -9999 0 -0.61 9 9
elevation of cytosolic calcium ion concentration -0.055 0.14 -9999 0 -0.4 22 22
alphaM/beta2 Integrin/JAM2/JAM3 -0.043 0.17 -9999 0 -0.44 24 24
JAM2 -0.041 0.17 -9999 0 -0.6 18 18
alphaM/beta2 Integrin/ICAM1 -0.059 0.17 -9999 0 -0.6 13 13
alphaM/beta2 Integrin/uPA/Plg -0.063 0.15 -9999 0 -0.43 23 23
RhoA/GTP -0.11 0.17 -9999 0 -0.46 24 24
positive regulation of phagocytosis -0.097 0.16 -9999 0 -0.52 16 16
Ron/MSP -0.008 0.11 -9999 0 -0.45 12 12
alphaM/beta2 Integrin/uPAR/uPA -0.03 0.15 -9999 0 -0.41 22 22
alphaM/beta2 Integrin/uPAR -0.043 0.13 -9999 0 -0.48 13 13
PLAU -0.021 0.14 -9999 0 -0.62 11 11
PLAT -0.094 0.23 -9999 0 -0.6 36 36
actin filament polymerization -0.1 0.16 -9999 0 -0.42 26 26
MST1 0.006 0.062 -9999 0 -0.62 2 2
alphaM/beta2 Integrin/lipoprotein(a) -0.11 0.17 -9999 0 -0.41 35 35
TNF -0.066 0.26 -9999 0 -0.74 19 19
RAP1B 0.013 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/uPA -0.062 0.15 -9999 0 -0.42 27 27
fibrinolysis -0.065 0.15 -9999 0 -0.43 23 23
HCK -0.015 0.13 -9999 0 -0.62 9 9
dendritic cell antigen processing and presentation -0.095 0.15 -9999 0 -0.4 28 28
VTN -0.061 0.19 -9999 0 -0.54 27 27
alphaM/beta2 Integrin/CYR61 -0.067 0.15 -9999 0 -0.41 31 31
LPA -0.1 0.23 -9999 0 -0.57 39 39
LRP1 0 0.088 -9999 0 -0.62 4 4
cell migration -0.071 0.2 -9999 0 -0.46 32 32
FN1 -0.089 0.22 -9999 0 -0.57 36 36
alphaM/beta2 Integrin/Thy1 -0.056 0.15 -9999 0 -0.44 23 23
MPO -0.006 0.093 -9999 0 -0.54 6 6
KNG1 -0.029 0.13 -9999 0 -0.54 12 12
RAP1/GDP 0.015 0.028 -9999 0 -0.39 1 1
ROCK1 -0.098 0.16 -9999 0 -0.43 24 24
ELA2 0 0 -9999 0 -10000 0 0
PLG -0.017 0.098 -9999 0 -0.54 7 7
CTGF -0.043 0.17 -9999 0 -0.59 19 19
alphaM/beta2 Integrin/Hck -0.058 0.16 -9999 0 -0.52 18 18
ITGAM -0.025 0.13 -9999 0 -0.57 11 11
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.073 0.2 -9999 0 -0.44 38 38
HP -0.17 0.27 -9999 0 -0.57 65 65
leukocyte adhesion -0.087 0.16 -9999 0 -0.55 14 14
SELP -0.087 0.23 -9999 0 -0.61 33 33
Wnt signaling

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.093 0.18 -9999 0 -0.5 16 16
FZD6 0.01 0.044 -9999 0 -0.62 1 1
WNT6 -0.043 0.17 -9999 0 -0.56 20 20
WNT4 -0.066 0.21 -9999 0 -0.61 26 26
FZD3 -0.037 0.17 -9999 0 -0.59 17 17
WNT5A -0.014 0.12 -9999 0 -0.6 9 9
WNT11 -0.086 0.22 -9999 0 -0.57 35 35
BCR signaling pathway

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.062 0.18 -10000 0 -0.44 31 31
IKBKB -0.015 0.089 -10000 0 -0.27 8 8
AKT1 -0.04 0.12 0.22 2 -0.27 31 33
IKBKG -0.015 0.094 -10000 0 -0.29 8 8
CALM1 -0.066 0.18 0.25 1 -0.48 24 25
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
MAP3K1 -0.1 0.26 -10000 0 -0.66 30 30
MAP3K7 0.013 0 -10000 0 -10000 0 0
mol:Ca2+ -0.077 0.19 0.24 2 -0.52 24 26
DOK1 0.013 0 -10000 0 -10000 0 0
AP-1 -0.031 0.11 0.17 2 -0.25 24 26
LYN 0.01 0.044 -10000 0 -0.62 1 1
BLNK -0.021 0.14 -10000 0 -0.62 11 11
SHC1 0.013 0 -10000 0 -10000 0 0
BCR complex -0.13 0.27 -10000 0 -0.56 52 52
CD22 -0.16 0.33 -10000 0 -0.85 30 30
CAMK2G -0.055 0.16 0.25 1 -0.5 18 19
CSNK2A1 0.013 0 -10000 0 -10000 0 0
INPP5D 0.006 0.062 -10000 0 -0.62 2 2
SHC/GRB2/SOS1 -0.11 0.19 -10000 0 -0.55 23 23
GO:0007205 -0.079 0.19 0.24 2 -0.53 24 26
SYK 0.006 0.062 -10000 0 -0.62 2 2
ELK1 -0.068 0.18 0.25 1 -0.51 22 23
NFATC1 -0.095 0.23 -10000 0 -0.56 32 32
B-cell antigen/BCR complex -0.13 0.27 -10000 0 -0.56 52 52
PAG1/CSK 0.017 0.033 -10000 0 -0.46 1 1
NFKBIB 0.005 0.032 0.078 1 -10000 0 1
HRAS -0.066 0.18 0.23 1 -0.49 24 25
NFKBIA 0.005 0.032 0.078 1 -10000 0 1
NF-kappa-B/RelA/I kappa B beta 0.011 0.027 -10000 0 -10000 0 0
RasGAP/Csk -0.098 0.26 -10000 0 -0.54 43 43
mol:GDP -0.075 0.18 0.27 1 -0.5 24 25
PTEN 0 0.088 -10000 0 -0.62 4 4
CD79B -0.055 0.19 -10000 0 -0.59 23 23
NF-kappa-B/RelA/I kappa B alpha 0.011 0.027 -10000 0 -10000 0 0
GRB2 0.013 0 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.12 0.25 -10000 0 -0.56 38 38
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
mol:IP3 -0.08 0.2 0.24 2 -0.54 24 26
CSK 0.013 0 -10000 0 -10000 0 0
FOS -0.082 0.18 0.25 1 -0.48 25 26
CHUK -0.015 0.094 -10000 0 -0.29 8 8
IBTK 0.013 0 -10000 0 -10000 0 0
CARD11/BCL10/MALT1/TAK1 -0.079 0.16 -10000 0 -0.5 21 21
PTPN6 -0.12 0.31 -10000 0 -0.79 29 29
RELA 0.013 0 -10000 0 -10000 0 0
BCL2A1 0.009 0.029 -10000 0 -0.12 5 5
VAV2 -0.18 0.32 -10000 0 -0.7 43 43
ubiquitin-dependent protein catabolic process 0.009 0.031 0.081 1 -10000 0 1
BTK -0.06 0.25 0.37 2 -1.1 11 13
CD19 -0.19 0.34 -10000 0 -0.79 39 39
MAP4K1 -0.017 0.13 -10000 0 -0.61 10 10
CD72 -0.028 0.15 -10000 0 -0.58 14 14
PAG1 0.01 0.044 -10000 0 -0.62 1 1
MAPK14 -0.075 0.22 -10000 0 -0.53 30 30
SH3BP5 0.004 0.073 -10000 0 -0.6 3 3
PIK3AP1 -0.079 0.21 0.24 2 -0.61 21 23
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.11 0.27 -10000 0 -0.6 39 39
RAF1 -0.055 0.17 -10000 0 -0.51 18 18
RasGAP/p62DOK/SHIP -0.12 0.24 -10000 0 -0.68 25 25
CD79A -0.13 0.26 -10000 0 -0.6 47 47
re-entry into mitotic cell cycle -0.032 0.11 0.18 2 -0.25 25 27
RASA1 0.003 0.076 -10000 0 -0.62 3 3
MAPK3 -0.032 0.14 -10000 0 -0.41 18 18
MAPK1 -0.032 0.14 -10000 0 -0.41 18 18
CD72/SHP1 -0.12 0.31 -10000 0 -0.77 31 31
NFKB1 0.01 0.038 -10000 0 -0.54 1 1
MAPK8 -0.087 0.22 -10000 0 -0.53 34 34
actin cytoskeleton organization -0.12 0.26 -10000 0 -0.56 43 43
NF-kappa-B/RelA 0.027 0.05 -10000 0 -10000 0 0
Calcineurin -0.066 0.14 -10000 0 -0.45 18 18
PI3K -0.14 0.22 -10000 0 -0.57 34 34
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.08 0.2 0.24 2 -0.56 24 26
SOS1 0.013 0 -10000 0 -10000 0 0
Bam32/HPK1 -0.13 0.32 -10000 0 -0.9 27 27
DAPP1 -0.17 0.35 -10000 0 -1 27 27
cytokine secretion -0.086 0.21 -10000 0 -0.51 32 32
mol:DAG -0.08 0.2 0.24 2 -0.54 24 26
PLCG2 0.01 0.044 -10000 0 -0.62 1 1
MAP2K1 -0.044 0.16 -10000 0 -0.46 18 18
B-cell antigen/BCR complex/FcgammaRIIB -0.12 0.28 -10000 0 -0.56 52 52
mol:PI-3-4-5-P3 -0.096 0.15 0.3 2 -0.38 33 35
ETS1 -0.05 0.16 0.24 1 -0.46 20 21
B-cell antigen/BCR complex/LYN/SYK/BLNK -0.098 0.23 -10000 0 -0.64 23 23
B-cell antigen/BCR complex/LYN -0.15 0.32 -10000 0 -0.68 39 39
MALT1 0.013 0 -10000 0 -10000 0 0
TRAF6 0.013 0 -10000 0 -10000 0 0
RAC1 -0.13 0.29 -10000 0 -0.62 43 43
B-cell antigen/BCR complex/LYN/SYK -0.15 0.3 -10000 0 -0.79 30 30
CARD11 -0.084 0.21 0.25 1 -0.59 24 25
FCGR2B -0.027 0.15 -10000 0 -0.61 13 13
PPP3CA 0.013 0 -10000 0 -10000 0 0
BCL10 0.013 0 -10000 0 -10000 0 0
IKK complex 0.003 0.041 -10000 0 -0.1 1 1
PTPRC -0.039 0.17 -10000 0 -0.61 17 17
PDPK1 -0.042 0.12 0.2 2 -0.27 27 29
PPP3CB 0.013 0 -10000 0 -10000 0 0
PPP3CC 0.013 0 -10000 0 -10000 0 0
POU2F2 0.011 0.026 -10000 0 -0.11 3 3
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 -0.016 0.13 -10000 0 -0.64 8 8
NFATC2 -0.097 0.29 -10000 0 -0.69 29 29
NFATC3 -0.007 0.07 -10000 0 -10000 0 0
CD40LG -0.26 0.43 -10000 0 -1.1 29 29
ITCH -0.058 0.13 -10000 0 -10000 0 0
CBLB -0.059 0.13 -10000 0 -0.47 1 1
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.25 0.43 -10000 0 -1.2 26 26
JUNB 0.013 0 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.11 0.13 -10000 0 -10000 0 0
T cell anergy -0.13 0.19 -10000 0 -0.42 43 43
TLE4 -0.093 0.3 -10000 0 -0.79 25 25
Jun/NFAT1-c-4/p21SNFT -0.15 0.33 -10000 0 -1 12 12
AP-1/NFAT1-c-4 -0.28 0.47 -10000 0 -1.2 27 27
IKZF1 -0.084 0.3 -10000 0 -0.91 18 18
T-helper 2 cell differentiation -0.12 0.29 -10000 0 -0.76 21 21
AP-1/NFAT1 -0.12 0.22 -10000 0 -0.6 23 23
CALM1 -0.042 0.084 -10000 0 -10000 0 0
EGR2 -0.1 0.31 -10000 0 -1.2 8 8
EGR3 -0.096 0.26 -10000 0 -0.93 6 6
NFAT1/FOXP3 -0.087 0.28 -10000 0 -0.8 19 19
EGR1 -0.014 0.12 -10000 0 -0.57 9 9
JUN -0.005 0.05 -10000 0 -0.63 1 1
EGR4 -0.11 0.24 -10000 0 -0.57 42 42
mol:Ca2+ -0.058 0.089 -10000 0 -10000 0 0
GBP3 -0.068 0.26 -10000 0 -0.74 17 17
FOSL1 -0.044 0.18 -10000 0 -0.6 19 19
NFAT1-c-4/MAF/IRF4 -0.16 0.35 -10000 0 -1.1 17 17
DGKA -0.069 0.25 -10000 0 -0.77 16 16
CREM 0.012 0.001 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.18 0.32 -10000 0 -0.97 19 19
CTLA4 -0.099 0.32 -10000 0 -0.95 21 21
NFAT1-c-4 (dimer)/EGR1 -0.13 0.32 -10000 0 -0.95 15 15
NFAT1-c-4 (dimer)/EGR4 -0.19 0.33 -10000 0 -0.94 19 19
FOS -0.056 0.17 -10000 0 -0.58 19 19
IFNG -0.31 0.5 -10000 0 -1.1 48 48
T cell activation -0.086 0.24 -10000 0 -0.69 10 10
MAF -0.027 0.15 -10000 0 -0.62 13 13
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.072 0.22 1.1 3 -10000 0 3
TNF -0.2 0.34 -10000 0 -0.94 21 21
FASLG -0.21 0.47 -10000 0 -1.4 21 21
TBX21 -0.047 0.17 -10000 0 -0.63 16 16
BATF3 0.007 0.058 -10000 0 -0.58 2 2
PRKCQ -0.052 0.19 -10000 0 -0.63 20 20
PTPN1 -0.053 0.22 -10000 0 -0.7 11 11
NFAT1-c-4/ICER1 -0.14 0.28 -10000 0 -0.96 11 11
GATA3 -0.061 0.2 -10000 0 -0.6 25 25
T-helper 1 cell differentiation -0.27 0.5 -10000 0 -1.1 48 48
IL2RA -0.23 0.37 -10000 0 -1.1 25 25
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.053 0.22 -10000 0 -0.64 14 14
E2F1 0.019 0 -10000 0 -10000 0 0
PPARG -0.087 0.22 -10000 0 -0.56 36 36
SLC3A2 -0.053 0.22 -10000 0 -0.66 13 13
IRF4 -0.047 0.18 -10000 0 -0.6 20 20
PTGS2 -0.28 0.43 -10000 0 -1.1 30 30
CSF2 -0.28 0.42 -10000 0 -1 32 32
JunB/Fra1/NFAT1-c-4 -0.14 0.3 -10000 0 -0.92 13 13
IL4 -0.12 0.31 -10000 0 -0.81 20 20
IL5 -0.24 0.4 -10000 0 -1.1 25 25
IL2 -0.087 0.24 -10000 0 -0.71 9 9
IL3 -0.051 0.052 -10000 0 -10000 0 0
RNF128 -0.21 0.32 -10000 0 -0.58 82 82
NFATC1 -0.072 0.22 -10000 0 -1.1 3 3
CDK4 0.067 0.17 0.57 1 -10000 0 1
PTPRK -0.053 0.22 -10000 0 -0.7 11 11
IL8 -0.29 0.44 -10000 0 -1.1 32 32
POU2F1 0.013 0.002 -10000 0 -10000 0 0
Syndecan-4-mediated signaling events

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.047 0.16 -9999 0 -0.53 14 14
Syndecan-4/Syndesmos -0.08 0.21 -9999 0 -0.59 22 22
positive regulation of JNK cascade -0.12 0.24 -9999 0 -0.61 29 29
Syndecan-4/ADAM12 -0.11 0.24 -9999 0 -0.62 27 27
CCL5 -0.042 0.17 -9999 0 -0.58 19 19
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
DNM2 0.013 0 -9999 0 -10000 0 0
ITGA5 -0.01 0.11 -9999 0 -0.57 8 8
SDCBP 0.013 0 -9999 0 -10000 0 0
PLG -0.017 0.098 -9999 0 -0.54 7 7
ADAM12 -0.048 0.18 -9999 0 -0.58 21 21
mol:GTP 0 0 -9999 0 -10000 0 0
NUDT16L1 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
Syndecan-4/PKC alpha -0.026 0.043 -9999 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.16 0.24 -9999 0 -0.61 32 32
Syndecan-4/CXCL12/CXCR4 -0.12 0.26 -9999 0 -0.66 29 29
Syndecan-4/Laminin alpha3 -0.11 0.24 -9999 0 -0.62 27 27
MDK 0.001 0.085 -9999 0 -0.6 4 4
Syndecan-4/FZD7 -0.099 0.22 -9999 0 -0.61 22 22
Syndecan-4/Midkine -0.086 0.22 -9999 0 -0.6 22 22
FZD7 -0.027 0.15 -9999 0 -0.57 14 14
Syndecan-4/FGFR1/FGF -0.15 0.22 -9999 0 -0.59 29 29
THBS1 -0.028 0.15 -9999 0 -0.55 15 15
integrin-mediated signaling pathway -0.11 0.22 -9999 0 -0.6 24 24
positive regulation of MAPKKK cascade -0.12 0.24 -9999 0 -0.61 29 29
Syndecan-4/TACI -0.13 0.24 -9999 0 -0.62 29 29
CXCR4 -0.032 0.16 -9999 0 -0.6 15 15
cell adhesion -0.027 0.13 -9999 0 -0.36 18 18
Syndecan-4/Dynamin -0.08 0.21 -9999 0 -0.59 22 22
Syndecan-4/TSP1 -0.099 0.23 -9999 0 -0.6 27 27
Syndecan-4/GIPC -0.08 0.21 -9999 0 -0.59 22 22
Syndecan-4/RANTES -0.11 0.23 -9999 0 -0.62 24 24
ITGB1 0.013 0 -9999 0 -10000 0 0
LAMA1 -0.14 0.26 -9999 0 -0.57 55 55
LAMA3 -0.043 0.17 -9999 0 -0.59 19 19
RAC1 0.013 0 -9999 0 -10000 0 0
PRKCA 0.02 0.083 -9999 0 -0.56 3 3
Syndecan-4/alpha-Actinin -0.08 0.21 -9999 0 -0.59 22 22
TFPI -0.049 0.18 -9999 0 -0.57 22 22
F2 -0.021 0.12 -9999 0 -0.53 10 10
alpha5/beta1 Integrin 0.002 0.083 -9999 0 -0.41 8 8
positive regulation of cell adhesion -0.17 0.26 -9999 0 -0.63 35 35
ACTN1 0.013 0 -9999 0 -10000 0 0
TNC -0.052 0.19 -9999 0 -0.59 22 22
Syndecan-4/CXCL12 -0.11 0.24 -9999 0 -0.62 28 28
FGF6 0 0.001 -9999 0 -10000 0 0
RHOA 0.013 0 -9999 0 -10000 0 0
CXCL12 -0.055 0.19 -9999 0 -0.59 23 23
TNFRSF13B -0.096 0.23 -9999 0 -0.58 37 37
FGF2 -0.041 0.17 -9999 0 -0.57 19 19
FGFR1 -0.049 0.18 -9999 0 -0.56 22 22
Syndecan-4/PI-4-5-P2 -0.088 0.21 -9999 0 -0.59 22 22
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.087 0.22 -9999 0 -0.56 36 36
cell migration -0.006 0.017 -9999 0 -10000 0 0
PRKCD 0.014 0.008 -9999 0 -10000 0 0
vasculogenesis -0.095 0.22 -9999 0 -0.57 27 27
SDC4 -0.092 0.22 -9999 0 -0.63 22 22
Syndecan-4/Tenascin C -0.11 0.24 -9999 0 -0.63 24 24
Syndecan-4/PI-4-5-P2/PKC alpha -0.021 0.034 -9999 0 -10000 0 0
Syndecan-4/Syntenin -0.08 0.21 -9999 0 -0.59 22 22
MMP9 -0.065 0.2 -9999 0 -0.59 27 27
Rac1/GTP -0.029 0.13 -9999 0 -0.37 18 18
cytoskeleton organization -0.077 0.2 -9999 0 -0.56 22 22
GIPC1 0.013 0 -9999 0 -10000 0 0
Syndecan-4/TFPI -0.11 0.23 -9999 0 -0.61 23 23
Ephrin A reverse signaling

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade -0.025 0.11 -9999 0 -0.36 21 21
EFNA5 -0.021 0.14 -9999 0 -0.62 11 11
FYN -0.022 0.12 -9999 0 -0.34 24 24
neuron projection morphogenesis -0.025 0.11 -9999 0 -0.36 21 21
cell-cell signaling 0 0 -9999 0 -10000 0 0
Ephrin A5/EPHA5 -0.025 0.11 -9999 0 -0.36 21 21
EPHA5 -0.02 0.12 -9999 0 -0.54 10 10
Nectin adhesion pathway

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.093 -9999 0 -0.59 5 5
alphaV beta3 Integrin -0.056 0.17 -9999 0 -0.44 34 34
PTK2 -0.11 0.18 -9999 0 -0.5 29 29
positive regulation of JNK cascade -0.048 0.1 -9999 0 -0.32 23 23
CDC42/GDP -0.025 0.16 -9999 0 -0.43 23 23
Rac1/GDP -0.023 0.16 -9999 0 -0.42 23 23
RAP1B 0.013 0 -9999 0 -10000 0 0
RAP1A 0.01 0.044 -9999 0 -0.62 1 1
CTNNB1 0.013 0 -9999 0 -10000 0 0
CDC42/GTP -0.058 0.13 -9999 0 -0.4 23 23
nectin-3/I-afadin -0.054 0.17 -9999 0 -0.43 33 33
RAPGEF1 -0.037 0.17 -9999 0 -0.48 23 23
mol:GTP 0 0 -9999 0 -10000 0 0
CRK -0.051 0.19 -9999 0 -0.56 23 23
PDGFB-D/PDGFRB -0.002 0.093 -9999 0 -0.59 5 5
TLN1 -0.014 0.092 -9999 0 -0.36 4 4
Rap1/GTP -0.05 0.11 -9999 0 -0.34 23 23
IQGAP1 0.013 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0.023 0.026 -9999 0 -0.35 1 1
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.054 0.17 -9999 0 -0.43 33 33
PVR 0.007 0.058 -9999 0 -0.58 2 2
Necl-5(dimer) 0.007 0.058 -9999 0 -0.58 2 2
mol:GDP -0.04 0.19 -9999 0 -0.53 23 23
MLLT4 0.013 0 -9999 0 -10000 0 0
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
PI3K -0.038 0.15 -9999 0 -0.34 28 28
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin -0.013 0.12 -9999 0 -0.46 14 14
positive regulation of lamellipodium assembly -0.051 0.11 -9999 0 -0.33 24 24
PVRL1 -0.03 0.16 -9999 0 -0.62 14 14
PVRL3 -0.085 0.22 -9999 0 -0.6 33 33
PVRL2 0.01 0.038 -9999 0 -0.54 1 1
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
CDH1 0.013 0 -9999 0 -10000 0 0
CLDN1 -0.098 0.24 -9999 0 -0.62 36 36
JAM-A/CLDN1 -0.089 0.19 -9999 0 -0.37 55 55
SRC -0.094 0.2 -9999 0 -0.61 24 24
ITGB3 -0.084 0.22 -9999 0 -0.57 34 34
nectin-1(dimer)/I-afadin/I-afadin -0.013 0.12 -9999 0 -0.46 14 14
FARP2 -0.044 0.19 -9999 0 -0.53 23 23
RAC1 0.013 0 -9999 0 -10000 0 0
CTNNA1 0.013 0 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) -0.04 0.15 -9999 0 -0.37 34 34
nectin-1/I-afadin -0.013 0.12 -9999 0 -0.46 14 14
nectin-2/I-afadin 0.017 0.028 -9999 0 -0.38 1 1
RAC1/GTP/IQGAP1/filamentous actin 0.017 0 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.064 0.18 -9999 0 -0.39 44 44
CDC42/GTP/IQGAP1/filamentous actin 0.017 0 -9999 0 -10000 0 0
F11R 0.013 0 -9999 0 -10000 0 0
positive regulation of filopodium formation -0.048 0.1 -9999 0 -0.32 23 23
alphaV/beta3 Integrin/Talin -0.05 0.16 -9999 0 -0.44 17 17
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.028 -9999 0 -0.38 1 1
nectin-2(dimer)/I-afadin/I-afadin 0.017 0.028 -9999 0 -0.38 1 1
PIP5K1C -0.022 0.098 -9999 0 -0.39 4 4
VAV2 -0.046 0.19 -9999 0 -0.53 24 24
RAP1/GDP -0.058 0.13 -9999 0 -0.4 23 23
ITGAV 0.006 0.062 -9999 0 -0.62 2 2
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin -0.038 0.14 -9999 0 -0.36 34 34
nectin-3(dimer)/I-afadin/I-afadin -0.054 0.17 -9999 0 -0.43 33 33
Rac1/GTP -0.061 0.13 -9999 0 -0.4 24 24
PTPRM -0.034 0.11 -9999 0 -0.25 34 34
E-cadherin/beta catenin/alpha catenin -0.021 0.076 -9999 0 -10000 0 0
adherens junction assembly 0 0 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
Effects of Botulinum toxin

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A 0.003 0.058 -9999 0 -0.41 4 4
UniProt:P19321 0 0 -9999 0 -10000 0 0
RIMS1/UNC13B -0.025 0.12 -9999 0 -0.39 20 20
STXBP1 -0.012 0.12 -9999 0 -0.61 8 8
ACh/CHRNA1 -0.06 0.14 -9999 0 -0.38 32 32
RAB3GAP2/RIMS1/UNC13B -0.012 0.1 -9999 0 -0.32 20 20
mol:Ca2+ 0 0 -9999 0 -10000 0 0
UniProt:P30996 0 0 -9999 0 -10000 0 0
UniProt:Q60393 0 0 -9999 0 -10000 0 0
CST086 0 0 -9999 0 -10000 0 0
RIMS1 -0.044 0.16 -9999 0 -0.54 19 19
mol:ACh -0.011 0.043 -9999 0 -0.098 38 38
RAB3GAP2 0.013 0 -9999 0 -10000 0 0
STX1A/SNAP25/VAMP2 -0.054 0.1 -9999 0 -0.38 10 10
UniProt:P10844 0 0 -9999 0 -10000 0 0
muscle contraction -0.06 0.14 -9999 0 -0.38 32 32
UNC13B 0.01 0.044 -9999 0 -0.62 1 1
CHRNA1 -0.079 0.21 -9999 0 -0.57 32 32
UniProt:P10845 0 0 -9999 0 -10000 0 0
ACh/Synaptotagmin 1 -0.12 0.18 -9999 0 -0.38 63 63
SNAP25 -0.034 0.094 -9999 0 -0.24 35 35
VAMP2 0.006 0 -9999 0 -10000 0 0
SYT1 -0.16 0.27 -9999 0 -0.56 63 63
UniProt:Q00496 0 0 -9999 0 -10000 0 0
STXIA/STXBP1 -0.005 0.091 -9999 0 -0.37 12 12
STX1A/SNAP25 fragment 1/VAMP2 -0.054 0.1 -9999 0 -0.38 10 10
IL27-mediated signaling events

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.009 0.1 -10000 0 -0.62 5 5
CD4-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
cytokine production during immune response 0.086 0.22 0.54 22 -10000 0 22
IL27/IL27R/JAK1 -0.1 0.24 -10000 0 -0.73 12 12
TBX21 -0.11 0.25 -10000 0 -0.6 27 27
IL12B -0.027 0.14 -10000 0 -0.56 13 13
IL12A -0.044 0.14 -10000 0 -0.43 25 25
IL6ST -0.089 0.23 -10000 0 -0.63 32 32
IL27RA/JAK1 -0.011 0.14 -10000 0 -1.3 2 2
IL27 -0.006 0.085 -10000 0 -0.54 5 5
TYK2 0.011 0.007 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.055 0.14 -10000 0 -0.68 2 2
T-helper 2 cell differentiation 0.086 0.22 0.54 22 -10000 0 22
T cell proliferation during immune response 0.086 0.22 0.54 22 -10000 0 22
MAPKKK cascade -0.086 0.22 -10000 0 -0.54 22 22
STAT3 0.013 0 -10000 0 -10000 0 0
STAT2 0.01 0.044 -10000 0 -0.62 1 1
STAT1 0.012 0.003 -10000 0 -10000 0 0
IL12RB1 -0.044 0.18 -10000 0 -0.61 18 18
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.15 0.29 -10000 0 -0.62 42 42
IL27/IL27R/JAK2/TYK2 -0.088 0.22 -10000 0 -0.55 22 22
positive regulation of T cell mediated cytotoxicity -0.086 0.22 -10000 0 -0.54 22 22
STAT1 (dimer) -0.15 0.32 0.5 7 -0.82 21 28
JAK2 0.002 0.071 -10000 0 -0.58 3 3
JAK1 0.012 0.003 -10000 0 -10000 0 0
STAT2 (dimer) -0.077 0.21 -10000 0 -0.56 18 18
T cell proliferation -0.13 0.24 -10000 0 -0.57 27 27
IL12/IL12R/TYK2/JAK2 -0.087 0.21 -10000 0 -0.69 13 13
IL17A -0.058 0.14 -10000 0 -0.68 2 2
mast cell activation 0.086 0.22 0.54 22 -10000 0 22
IFNG -0.026 0.053 -10000 0 -0.12 45 45
T cell differentiation -0.008 0.009 -10000 0 -0.023 38 38
STAT3 (dimer) -0.076 0.21 -10000 0 -0.54 19 19
STAT5A (dimer) -0.082 0.22 -10000 0 -0.56 21 21
STAT4 (dimer) -0.09 0.23 -10000 0 -0.6 22 22
STAT4 -0.017 0.13 -10000 0 -0.6 10 10
T cell activation -0.007 0.017 0.086 5 -10000 0 5
IL27R/JAK2/TYK2 -0.071 0.19 -10000 0 -1.1 3 3
GATA3 -0.098 0.38 -10000 0 -1.3 18 18
IL18 -0.01 0.094 -10000 0 -0.45 9 9
positive regulation of mast cell cytokine production -0.074 0.2 -10000 0 -0.52 19 19
IL27/EBI3 -0.035 0.15 -10000 0 -0.46 21 21
IL27RA -0.021 0.14 -10000 0 -1.4 2 2
IL6 -0.097 0.22 -10000 0 -0.57 37 37
STAT5A 0 0.088 -10000 0 -0.62 4 4
monocyte differentiation -0.001 0.003 -10000 0 -10000 0 0
IL2 0.012 0.064 0.52 2 -10000 0 2
IL1B -0.043 0.14 -10000 0 -0.41 26 26
EBI3 -0.042 0.17 -10000 0 -0.62 17 17
TNF -0.03 0.12 -10000 0 -0.42 19 19
Class IB PI3K non-lipid kinase events

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process 0.031 0.16 0.58 15 -10000 0 15
PI3K Class IB/PDE3B -0.031 0.16 -10000 0 -0.58 15 15
PDE3B -0.031 0.16 -10000 0 -0.58 15 15
Thromboxane A2 receptor signaling

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.072 0.21 -10000 0 -0.58 29 29
GNB1/GNG2 -0.052 0.073 -10000 0 -0.2 24 24
AKT1 -0.018 0.1 -10000 0 -0.21 16 16
EGF -0.081 0.21 -10000 0 -0.57 33 33
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR 0.022 0.074 -10000 0 -0.41 2 2
mol:Ca2+ -0.048 0.15 -10000 0 -0.31 37 37
LYN 0.024 0.063 -10000 0 -10000 0 0
RhoA/GTP -0.033 0.049 -10000 0 -0.14 2 2
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.052 0.17 -10000 0 -0.36 34 34
GNG2 0.01 0.038 -10000 0 -0.54 1 1
ARRB2 0.013 0 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.028 0.15 -10000 0 -0.42 22 22
G beta5/gamma2 -0.068 0.097 -10000 0 -0.27 23 23
PRKCH -0.055 0.17 -10000 0 -0.36 34 34
DNM1 -0.015 0.13 -10000 0 -0.62 9 9
TXA2/TP beta/beta Arrestin3 -0.012 0.047 -10000 0 -0.25 6 6
mol:GTP 0 0.001 -10000 0 -10000 0 0
PTGDR -0.002 0.093 -10000 0 -0.59 5 5
G12 family/GTP -0.082 0.12 -10000 0 -0.31 35 35
ADRBK1 0.013 0 -10000 0 -10000 0 0
ADRBK2 0 0.088 -10000 0 -0.62 4 4
RhoA/GTP/ROCK1 0.01 0.009 -10000 0 -10000 0 0
mol:GDP 0.025 0.11 0.4 7 -10000 0 7
mol:NADP 0.004 0.066 -10000 0 -0.54 3 3
RAB11A 0.013 0 -10000 0 -10000 0 0
PRKG1 -0.05 0.18 -10000 0 -0.59 21 21
mol:IP3 -0.065 0.18 -10000 0 -0.39 37 37
cell morphogenesis 0.009 0.009 -10000 0 -10000 0 0
PLCB2 -0.096 0.24 -10000 0 -0.53 37 37
mol:cGMP 0 0.001 -10000 0 -10000 0 0
BLK -0.017 0.11 -10000 0 -0.35 1 1
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK 0.013 0.094 -10000 0 -0.49 3 3
RHOA 0.013 0 -10000 0 -10000 0 0
PTGIR 0 0.088 -10000 0 -0.62 4 4
PRKCB1 -0.064 0.18 -10000 0 -0.39 36 36
GNAQ 0.01 0.044 -10000 0 -0.62 1 1
mol:L-citrulline 0.004 0.066 -10000 0 -0.54 3 3
TXA2/TXA2-R family -0.094 0.24 -10000 0 -0.55 35 35
LCK 0.018 0.088 -10000 0 -0.44 4 4
TXA2/TP beta/beta Arrestin3/RAB11/GDP -0.01 0.051 -10000 0 -10000 0 0
TXA2-R family/G12 family/GDP/G beta/gamma 0.027 0.02 -10000 0 -10000 0 0
TXA2/TP beta/beta Arrestin2/RAB11/GDP -0.01 0.05 -10000 0 -10000 0 0
MAPK14 -0.025 0.12 -10000 0 -0.24 23 23
TGM2/GTP -0.085 0.22 -10000 0 -0.46 41 41
MAPK11 -0.029 0.12 -10000 0 -0.25 25 25
ARHGEF1 -0.02 0.091 -10000 0 -0.19 17 17
GNAI2 0.013 0 -10000 0 -10000 0 0
JNK cascade -0.064 0.18 -10000 0 -0.4 35 35
RAB11/GDP 0.013 0.001 -10000 0 -10000 0 0
ICAM1 -0.043 0.14 -10000 0 -0.3 34 34
cAMP biosynthetic process -0.066 0.17 -10000 0 -0.36 38 38
Gq family/GTP/EBP50 -0.034 0.14 -10000 0 -0.36 23 23
actin cytoskeleton reorganization 0.009 0.009 -10000 0 -10000 0 0
SRC 0.026 0.06 -10000 0 -10000 0 0
GNB5 0.013 0 -10000 0 -10000 0 0
GNB1 0.013 0 -10000 0 -10000 0 0
EGF/EGFR -0.003 0.093 -10000 0 -0.33 5 5
VCAM1 -0.054 0.16 -10000 0 -0.34 40 40
TP beta/Gq family/GDP/G beta5/gamma2 -0.028 0.15 -10000 0 -0.42 22 22
platelet activation -0.037 0.16 -10000 0 -0.31 34 34
PGI2/IP -0.001 0.065 -10000 0 -0.46 4 4
PRKACA 0.007 0.06 -10000 0 -0.3 7 7
Gq family/GDP/G beta5/gamma2 -0.025 0.14 -10000 0 -0.38 22 22
TXA2/TP beta/beta Arrestin2 -0.024 0.11 -10000 0 -0.53 9 9
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R 0.011 0.063 -10000 0 -0.27 9 9
mol:DAG -0.072 0.2 -10000 0 -0.44 35 35
EGFR -0.033 0.16 -10000 0 -0.62 15 15
TXA2/TP alpha -0.093 0.23 -10000 0 -0.5 37 37
Gq family/GTP -0.047 0.1 -10000 0 -0.26 30 30
YES1 0.026 0.06 -10000 0 -10000 0 0
GNAI2/GTP -0.016 0.056 -10000 0 -10000 0 0
PGD2/DP -0.003 0.069 -10000 0 -0.44 5 5
SLC9A3R1 0 0.088 -10000 0 -0.62 4 4
FYN 0.02 0.077 -10000 0 -0.42 2 2
mol:NO 0.004 0.066 -10000 0 -0.54 3 3
GNA15 -0.039 0.17 -10000 0 -0.62 17 17
PGK/cGMP -0.027 0.12 -10000 0 -0.37 23 23
RhoA/GDP 0.013 0.001 -10000 0 -10000 0 0
TP alpha/TGM2/GDP/G beta/gamma -0.012 0.12 -10000 0 -0.53 2 2
NOS3 0.004 0.066 -10000 0 -0.54 3 3
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCA -0.058 0.17 -10000 0 -0.36 35 35
PRKCB -0.065 0.19 -10000 0 -0.39 38 38
PRKCE -0.052 0.17 -10000 0 -0.36 34 34
PRKCD -0.059 0.18 -10000 0 -0.39 35 35
PRKCG -0.079 0.19 -10000 0 -0.41 39 39
muscle contraction -0.086 0.23 -10000 0 -0.51 35 35
PRKCZ -0.051 0.16 -10000 0 -0.35 33 33
ARR3 0.003 0.005 -10000 0 -10000 0 0
TXA2/TP beta 0.003 0.071 -10000 0 -10000 0 0
PRKCQ -0.073 0.19 -10000 0 -0.39 37 37
MAPKKK cascade -0.083 0.22 -10000 0 -0.48 35 35
SELE -0.06 0.17 -10000 0 -0.37 37 37
TP beta/GNAI2/GDP/G beta/gamma 0.029 0.059 -10000 0 -10000 0 0
ROCK1 0.013 0 -10000 0 -10000 0 0
GNA14 -0.063 0.2 -10000 0 -0.56 27 27
chemotaxis -0.11 0.27 -10000 0 -0.61 36 36
GNA12 0.013 0 -10000 0 -10000 0 0
GNA13 0.013 0 -10000 0 -10000 0 0
GNA11 -0.009 0.12 -10000 0 -0.62 7 7
Rac1/GTP 0.006 0.005 -10000 0 -10000 0 0
Integrins in angiogenesis

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.01 0.061 -9999 0 -0.42 4 4
alphaV beta3 Integrin -0.071 0.19 -9999 0 -0.49 24 24
PTK2 -0.068 0.17 -9999 0 -0.53 13 13
IGF1R 0.001 0.085 -9999 0 -0.6 4 4
PI4KB 0.013 0 -9999 0 -10000 0 0
MFGE8 0.013 0 -9999 0 -10000 0 0
SRC 0.013 0 -9999 0 -10000 0 0
CDKN1B -0.059 0.095 -9999 0 -0.34 7 7
VEGFA 0.013 0 -9999 0 -10000 0 0
ILK -0.059 0.095 -9999 0 -0.34 7 7
ROCK1 0.013 0 -9999 0 -10000 0 0
AKT1 -0.031 0.098 -9999 0 -0.35 3 3
PTK2B -0.025 0.14 -9999 0 -0.6 4 4
alphaV/beta3 Integrin/JAM-A -0.085 0.2 -9999 0 -0.63 13 13
CBL 0.006 0.062 -9999 0 -0.62 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.045 0.15 -9999 0 -0.37 36 36
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.064 0.17 -9999 0 -0.36 37 37
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.016 0.1 -9999 0 -0.41 3 3
alphaV/beta3 Integrin/Syndecan-1 -0.049 0.16 -9999 0 -0.38 38 38
PI4KA 0.013 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.19 0.24 -9999 0 -0.68 29 29
PI4 Kinase 0.019 0 -9999 0 -10000 0 0
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
alphaV/beta3 Integrin/Osteopontin -0.099 0.19 -9999 0 -0.37 65 65
RPS6KB1 -0.15 0.24 -9999 0 -0.62 29 29
TLN1 0.013 0 -9999 0 -10000 0 0
MAPK3 -0.1 0.22 -9999 0 -0.6 24 24
GPR124 0.004 0.07 -9999 0 -0.57 3 3
MAPK1 -0.1 0.22 -9999 0 -0.6 24 24
PXN 0.013 0 -9999 0 -10000 0 0
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
alphaV/beta3 Integrin/Tumstatin -0.1 0.2 -9999 0 -0.38 64 64
cell adhesion -0.049 0.13 -9999 0 -0.41 14 14
ANGPTL3 0.003 0.054 -9999 0 -0.54 2 2
VEGFR2 homodimer/VEGFA homodimer/Src 0.019 0.052 -9999 0 -0.35 4 4
IGF-1R heterotetramer 0.001 0.085 -9999 0 -0.6 4 4
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
TGFBR2 0.01 0.044 -9999 0 -0.62 1 1
ITGB3 -0.084 0.22 -9999 0 -0.57 34 34
IGF1 -0.12 0.25 -9999 0 -0.59 44 44
RAC1 0.013 0 -9999 0 -10000 0 0
regulation of cell-matrix adhesion -0.044 0.16 -9999 0 -0.37 36 36
apoptosis 0.006 0.062 -9999 0 -0.62 2 2
CD47 0.01 0.044 -9999 0 -0.62 1 1
alphaV/beta3 Integrin/CD47 -0.041 0.15 -9999 0 -0.43 15 15
VCL 0.01 0.044 -9999 0 -0.62 1 1
alphaV/beta3 Integrin/Del1 -0.12 0.22 -9999 0 -0.41 68 68
CSF1 -0.003 0.098 -9999 0 -0.62 5 5
PIK3C2A -0.061 0.099 -9999 0 -0.41 4 4
PI4 Kinase/Pyk2 -0.095 0.16 -9999 0 -0.53 16 16
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.033 0.15 -9999 0 -0.41 17 17
FAK1/Vinculin -0.049 0.14 -9999 0 -0.41 13 13
alphaV beta3/Integrin/ppsTEM5 -0.044 0.16 -9999 0 -0.37 36 36
RHOA 0.013 0 -9999 0 -10000 0 0
VTN -0.061 0.19 -9999 0 -0.54 27 27
BCAR1 0.013 0 -9999 0 -10000 0 0
FGF2 -0.041 0.17 -9999 0 -0.57 19 19
F11R -0.018 0.12 -9999 0 -0.41 19 19
alphaV/beta3 Integrin/Lactadherin -0.039 0.15 -9999 0 -0.37 34 34
alphaV/beta3 Integrin/TGFBR2 -0.041 0.15 -9999 0 -0.37 35 35
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.017 0.09 -9999 0 -0.44 7 7
HSP90AA1 0.013 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Talin -0.035 0.14 -9999 0 -0.34 34 34
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.089 0.22 -9999 0 -0.57 36 36
alphaV/beta3 Integrin/Pyk2 -0.024 0.14 -9999 0 -0.6 4 4
SDC1 -0.003 0.098 -9999 0 -0.62 5 5
VAV3 -0.006 0.12 -9999 0 -0.64 2 2
PTPN11 0.013 0 -9999 0 -10000 0 0
IRS1 -0.012 0.12 -9999 0 -0.61 8 8
FAK1/Paxillin -0.048 0.14 -9999 0 -0.41 13 13
cell migration -0.038 0.13 -9999 0 -0.38 9 9
ITGAV 0.006 0.062 -9999 0 -0.62 2 2
PI3K -0.11 0.18 -9999 0 -0.58 16 16
SPP1 -0.083 0.22 -9999 0 -0.57 34 34
KDR 0.001 0.082 -9999 0 -0.58 4 4
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.006 0.062 -9999 0 -0.62 2 2
COL4A3 -0.088 0.22 -9999 0 -0.57 35 35
angiogenesis -0.1 0.22 -9999 0 -0.6 24 24
Rac1/GTP 0.001 0.11 -9999 0 -0.59 2 2
EDIL3 -0.12 0.24 -9999 0 -0.58 44 44
cell proliferation -0.041 0.15 -9999 0 -0.36 35 35
IGF1 pathway

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.013 0 -10000 0 -10000 0 0
PTK2 0.013 0 -10000 0 -10000 0 0
CRKL -0.054 0.14 -10000 0 -0.33 31 31
GRB2/SOS1/SHC 0.026 0 -10000 0 -10000 0 0
HRAS 0.013 0 -10000 0 -10000 0 0
IRS1/Crk -0.054 0.14 -10000 0 -0.33 31 31
IGF-1R heterotetramer/IGF1/PTP1B -0.079 0.15 -10000 0 -0.34 47 47
AKT1 -0.042 0.15 -10000 0 -0.6 6 6
BAD -0.034 0.15 -10000 0 -0.59 6 6
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.054 0.14 -10000 0 -0.33 31 31
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.055 0.14 -10000 0 -0.33 31 31
RAF1 -0.025 0.14 -10000 0 -0.53 6 6
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.044 0.14 -10000 0 -0.31 31 31
YWHAZ 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.067 0.16 -10000 0 -0.31 54 54
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
RPS6KB1 -0.042 0.15 -10000 0 -0.6 6 6
GNB2L1 0.013 0 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.023 0.12 -10000 0 -0.44 6 6
PXN 0.013 0 -10000 0 -10000 0 0
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
HRAS/GTP -0.059 0.11 -10000 0 -0.8 1 1
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.032 0.13 -10000 0 -0.68 1 1
IGF-1R heterotetramer -0.017 0.093 -10000 0 -0.64 4 4
IGF-1R heterotetramer/IGF1/IRS/Nck -0.054 0.14 -10000 0 -0.33 31 31
Crk/p130 Cas/Paxillin -0.036 0.13 -10000 0 -0.85 1 1
IGF1R -0.017 0.093 -10000 0 -0.64 4 4
IGF1 -0.12 0.25 -10000 0 -0.6 44 44
IRS2/Crk -0.055 0.15 -10000 0 -0.32 36 36
PI3K -0.057 0.16 -10000 0 -0.34 34 34
apoptosis 0.022 0.13 0.49 6 -10000 0 6
HRAS/GDP 0.009 0 -10000 0 -10000 0 0
PRKCD -0.044 0.16 -10000 0 -0.4 31 31
RAF1/14-3-3 E -0.014 0.12 -10000 0 -0.47 5 5
BAD/14-3-3 -0.024 0.14 -10000 0 -0.53 6 6
PRKCZ -0.042 0.15 -10000 0 -0.6 6 6
Crk/p130 Cas/Paxillin/FAK1 -0.058 0.11 -10000 0 -0.5 6 6
PTPN1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.054 0.17 -10000 0 -0.42 31 31
BCAR1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.053 0.16 -10000 0 -0.36 33 33
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.013 0 -10000 0 -10000 0 0
IRS1/NCK2 -0.054 0.14 -10000 0 -0.33 31 31
GRB10 -0.003 0.098 -10000 0 -0.62 5 5
PTPN11 -0.054 0.14 -10000 0 -0.33 31 31
IRS1 -0.067 0.15 -10000 0 -0.31 54 54
IRS2 -0.066 0.16 -10000 0 -0.34 38 38
IGF-1R heterotetramer/IGF1 -0.092 0.2 -10000 0 -0.45 47 47
GRB2 0.013 0 -10000 0 -10000 0 0
PDPK1 -0.051 0.16 -10000 0 -0.65 6 6
YWHAE 0.013 0 -10000 0 -10000 0 0
PRKD1 -0.082 0.19 -10000 0 -0.43 38 38
SHC1 0.013 0 -10000 0 -10000 0 0
Plasma membrane estrogen receptor signaling

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.029 0.14 -10000 0 -0.36 23 23
ER alpha/Gai/GDP/Gbeta gamma -0.053 0.18 -10000 0 -0.43 28 28
AKT1 -0.076 0.25 -10000 0 -0.77 23 23
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.076 0.26 -10000 0 -0.79 22 22
mol:Ca2+ -0.075 0.18 -10000 0 -0.47 22 22
IGF1R 0.001 0.085 -10000 0 -0.6 4 4
E2/ER alpha (dimer)/Striatin -0.07 0.17 -10000 0 -0.39 44 44
SHC1 0.013 0 -10000 0 -10000 0 0
apoptosis 0.071 0.24 0.73 23 -10000 0 23
RhoA/GTP -0.043 0.096 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.081 0.16 -10000 0 -0.47 22 22
regulation of stress fiber formation 0.017 0.13 0.46 6 -10000 0 6
E2/ERA-ERB (dimer) -0.05 0.15 -10000 0 -0.39 34 34
KRAS 0.01 0.038 -10000 0 -0.54 1 1
G13/GTP -0.04 0.13 -10000 0 -0.33 33 33
pseudopodium formation -0.017 0.13 -10000 0 -0.46 6 6
E2/ER alpha (dimer)/PELP1 -0.044 0.14 -10000 0 -0.37 33 33
GRB2 0.013 0 -10000 0 -10000 0 0
GNG2 0.01 0.038 -10000 0 -0.54 1 1
GNAO1 -0.016 0.13 -10000 0 -0.57 10 10
HRAS 0.013 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.048 0.19 -10000 0 -0.51 24 24
E2/ER beta (dimer) 0.003 0.054 -10000 0 -0.44 3 3
mol:GDP -0.06 0.14 -10000 0 -0.43 23 23
mol:NADP -0.048 0.19 -10000 0 -0.51 24 24
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
mol:IP3 -0.079 0.19 -10000 0 -0.5 22 22
IGF-1R heterotetramer 0.001 0.085 -10000 0 -0.6 4 4
PLCB1 -0.085 0.19 -10000 0 -0.48 25 25
PLCB2 -0.058 0.17 -10000 0 -0.48 21 21
IGF1 -0.12 0.25 -10000 0 -0.59 44 44
mol:L-citrulline -0.048 0.19 -10000 0 -0.51 24 24
RHOA 0.013 0 -10000 0 -10000 0 0
Gai/GDP -0.031 0.16 -10000 0 -0.71 6 6
JNK cascade 0.003 0.054 -10000 0 -0.44 3 3
BCAR1 0.013 0 -10000 0 -10000 0 0
ESR2 0.004 0.073 -10000 0 -0.6 3 3
GNAQ 0.01 0.044 -10000 0 -0.62 1 1
ESR1 -0.084 0.22 -10000 0 -0.59 33 33
Gq family/GDP/Gbeta gamma -0.047 0.19 -10000 0 -0.53 22 22
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 -0.009 0.099 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.081 0.16 -10000 0 -0.47 22 22
GNAZ -0.055 0.19 -10000 0 -0.59 23 23
E2/ER alpha (dimer) -0.062 0.16 -10000 0 -0.44 33 33
STRN -0.027 0.15 -10000 0 -0.62 13 13
GNAL -0.045 0.18 -10000 0 -0.58 20 20
PELP1 0.013 0 -10000 0 -10000 0 0
MAPK11 0.005 0.079 -10000 0 -0.44 6 6
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 -0.021 0.14 -10000 0 -0.62 11 11
HBEGF -0.059 0.17 -10000 0 -0.5 15 15
cAMP biosynthetic process -0.079 0.15 -10000 0 -0.37 31 31
SRC -0.044 0.17 -10000 0 -0.55 9 9
PI3K 0 0.089 -10000 0 -0.42 9 9
GNB1 0.013 0 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma -0.053 0.13 -10000 0 -0.39 22 22
SOS1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.11 0.17 -10000 0 -0.45 31 31
Gs family/GTP -0.08 0.15 -10000 0 -0.37 31 31
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.023 0.022 -10000 0 -0.29 1 1
vasodilation -0.045 0.18 -10000 0 -0.48 25 25
mol:DAG -0.079 0.19 -10000 0 -0.5 22 22
Gs family/GDP/Gbeta gamma -0.071 0.14 -10000 0 -0.41 22 22
MSN -0.019 0.14 -10000 0 -0.5 6 6
Gq family/GTP -0.066 0.18 -10000 0 -0.5 21 21
mol:PI-3-4-5-P3 -0.072 0.25 -10000 0 -0.76 22 22
NRAS 0.013 0 -10000 0 -10000 0 0
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.045 0.18 0.48 25 -10000 0 25
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
RhoA/GDP -0.055 0.13 -10000 0 -0.4 23 23
NOS3 -0.052 0.2 -10000 0 -0.54 24 24
GNA11 -0.009 0.12 -10000 0 -0.62 7 7
MAPKKK cascade -0.062 0.22 -10000 0 -0.58 27 27
E2/ER alpha (dimer)/PELP1/Src -0.086 0.17 -10000 0 -0.48 26 26
ruffle organization -0.017 0.13 -10000 0 -0.46 6 6
ROCK2 -0.014 0.12 -10000 0 -0.55 1 1
GNA14 -0.063 0.2 -10000 0 -0.56 27 27
GNA15 -0.039 0.17 -10000 0 -0.62 17 17
GNA13 0.013 0 -10000 0 -10000 0 0
MMP9 -0.073 0.19 -10000 0 -0.55 16 16
MMP2 -0.048 0.17 -10000 0 -0.57 9 9
ErbB4 signaling events

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF -0.025 0.089 -10000 0 -0.44 2 2
epithelial cell differentiation -0.11 0.14 -10000 0 -0.43 13 13
ITCH 0.027 0.018 -10000 0 -10000 0 0
WWP1 -0.018 0.074 -10000 0 -10000 0 0
FYN -0.001 0.088 -10000 0 -0.56 5 5
EGFR -0.033 0.16 -10000 0 -0.62 15 15
PRL -0.003 0.065 -10000 0 -0.54 3 3
neuron projection morphogenesis -0.043 0.14 -10000 0 -0.53 2 2
PTPRZ1 -0.16 0.28 -10000 0 -0.62 55 55
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.082 0.14 -10000 0 -0.46 6 6
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.089 0.17 -10000 0 -0.41 32 32
ADAM17 0.01 0.1 -10000 0 -0.62 5 5
ErbB4/ErbB4 -0.031 0.092 -10000 0 -0.3 6 6
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.045 0.098 -10000 0 -0.4 7 7
NCOR1 0.013 0 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.084 0.17 -10000 0 -0.44 25 25
GRIN2B -0.083 0.17 -10000 0 -0.46 18 18
ErbB4/ErbB2/betacellulin -0.056 0.15 -10000 0 -0.45 14 14
STAT1 0.013 0 -10000 0 -10000 0 0
HBEGF 0.004 0.07 -10000 0 -0.57 3 3
PRLR -0.18 0.28 -10000 0 -0.6 66 66
E4ICDs/ETO2 -0.049 0.13 -10000 0 -0.39 16 16
axon guidance 0.01 0.1 -10000 0 -0.37 1 1
NEDD4 0.007 0.11 -10000 0 -0.61 6 6
Prolactin receptor/Prolactin receptor/Prolactin -0.14 0.22 -10000 0 -0.45 67 67
CBFA2T3 -0.035 0.16 -10000 0 -0.6 16 16
ErbB4/ErbB2/HBEGF -0.02 0.1 -10000 0 -0.38 9 9
MAPK3 -0.051 0.14 -10000 0 -0.5 3 3
STAT1 (dimer) -0.02 0.077 -10000 0 -10000 0 0
MAPK1 -0.051 0.14 -10000 0 -0.5 3 3
JAK2 0.004 0.07 -10000 0 -0.57 3 3
ErbB4/ErbB2/neuregulin 1 beta -0.085 0.17 -10000 0 -0.43 24 24
NRG1 -0.08 0.2 -10000 0 -0.44 48 48
NRG3 -0.014 0.099 -10000 0 -0.54 7 7
NRG2 -0.05 0.18 -10000 0 -0.56 22 22
NRG4 -0.091 0.22 -10000 0 -0.56 37 37
heart development 0.01 0.1 -10000 0 -0.37 1 1
neural crest cell migration -0.084 0.17 -10000 0 -0.42 25 25
ERBB2 0.006 0.1 -10000 0 -0.41 11 11
WWOX/E4ICDs -0.022 0.081 -10000 0 -0.35 1 1
SHC1 0.013 0 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 -0.093 0.18 -10000 0 -0.43 33 33
apoptosis 0.064 0.074 0.33 3 -10000 0 3
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.058 0.14 -10000 0 -0.42 16 16
ErbB4/ErbB2/epiregulin -0.1 0.16 -10000 0 -0.39 26 26
ErbB4/ErbB4/betacellulin/betacellulin -0.064 0.14 -10000 0 -0.41 23 23
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.13 0.16 -10000 0 -0.48 20 20
MDM2 -0.02 0.088 -10000 0 -0.62 1 1
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.089 0.15 -10000 0 -0.38 32 32
STAT5A 0.01 0.11 -10000 0 -0.38 3 3
ErbB4/EGFR/neuregulin 1 beta -0.1 0.2 -10000 0 -0.51 28 28
DLG4 0.004 0.07 -10000 0 -0.57 3 3
GRB2/SHC 0.019 0 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 -0.038 0.057 -10000 0 -10000 0 0
STAT5A (dimer) -0.11 0.15 -10000 0 -0.48 10 10
MAP3K7IP2 0 0 -10000 0 -10000 0 0
STAT5B (dimer) 0.014 0.091 -10000 0 -0.34 1 1
LRIG1 -0.007 0.1 -10000 0 -0.56 7 7
EREG -0.15 0.26 -10000 0 -0.56 59 59
BTC -0.059 0.2 -10000 0 -0.62 23 23
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.01 0.1 -10000 0 -0.37 1 1
ERBB4 -0.031 0.092 -10000 0 -0.3 6 6
STAT5B 0.013 0 -10000 0 -10000 0 0
YAP1 -0.022 0.046 -10000 0 -0.25 1 1
GRB2 0.013 0 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 -0.071 0.14 -10000 0 -0.36 27 27
glial cell differentiation 0.038 0.057 -10000 0 -10000 0 0
WWOX 0.01 0.044 -10000 0 -0.62 1 1
cell proliferation -0.093 0.19 -10000 0 -0.5 22 22
Signaling events regulated by Ret tyrosine kinase

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.028 0.044 -9999 0 -10000 0 0
Crk/p130 Cas/Paxillin -0.08 0.12 -9999 0 -0.42 10 10
JUN -0.051 0.16 -9999 0 -0.53 10 10
HRAS 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 -0.1 0.2 -9999 0 -0.43 35 35
RAP1A 0.01 0.044 -9999 0 -0.62 1 1
FRS2 0.013 0 -9999 0 -10000 0 0
RAP1A/GDP 0.007 0.033 -9999 0 -0.46 1 1
RET51/GFRalpha1/GDNF/DOK1 -0.095 0.19 -9999 0 -0.42 32 32
EntrezGene:5979 0 0 -9999 0 -10000 0 0
PTPN11 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma -0.046 0.14 -9999 0 -0.32 39 39
RHOA 0.013 0 -9999 0 -10000 0 0
RAP1A/GTP -0.1 0.16 -9999 0 -0.56 9 9
GRB7 0.004 0.073 -9999 0 -0.6 3 3
RET51/GFRalpha1/GDNF -0.095 0.19 -9999 0 -0.42 32 32
MAPKKK cascade -0.087 0.14 -9999 0 -0.48 8 8
BCAR1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 -0.06 0.16 -9999 0 -0.35 44 44
lamellipodium assembly -0.075 0.11 -9999 0 -0.38 11 11
RET51/GFRalpha1/GDNF/SHC -0.095 0.19 -9999 0 -0.42 32 32
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
RET9/GFRalpha1/GDNF/SHC -0.046 0.14 -9999 0 -0.32 39 39
RET9/GFRalpha1/GDNF/Shank3 -0.048 0.14 -9999 0 -0.32 40 40
MAPK3 -0.073 0.16 -9999 0 -0.53 9 9
DOK1 0.013 0 -9999 0 -10000 0 0
DOK6 -0.021 0.14 -9999 0 -0.57 12 12
PXN 0.013 0 -9999 0 -10000 0 0
neurite development -0.063 0.16 -9999 0 -0.49 11 11
DOK5 -0.059 0.19 -9999 0 -0.57 25 25
GFRA1 -0.077 0.22 -9999 0 -0.6 30 30
MAPK8 -0.06 0.16 -9999 0 -0.46 15 15
HRAS/GTP -0.099 0.16 -9999 0 -0.52 10 10
tube development -0.039 0.13 -9999 0 -0.33 21 21
MAPK1 -0.073 0.16 -9999 0 -0.53 9 9
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.02 0.098 -9999 0 -0.27 21 21
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
SRC 0.013 0 -9999 0 -10000 0 0
PDLIM7 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok6 -0.1 0.2 -9999 0 -0.43 36 36
SHC1 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 -0.098 0.19 -9999 0 -0.42 33 33
RET51/GFRalpha1/GDNF/Dok5 -0.14 0.21 -9999 0 -0.45 45 45
PRKCA 0.004 0.073 -9999 0 -0.6 3 3
HRAS/GDP 0.009 0 -9999 0 -10000 0 0
CREB1 -0.036 0.12 -9999 0 -0.34 21 21
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.023 0.1 -9999 0 -0.27 23 23
RET51/GFRalpha1/GDNF/Grb7 -0.1 0.19 -9999 0 -0.42 34 34
mol:GDP 0 0 -9999 0 -10000 0 0
RET -0.088 0.22 -9999 0 -0.56 36 36
DOK4 0.007 0.058 -9999 0 -0.58 2 2
JNK cascade -0.05 0.15 -9999 0 -0.52 10 10
RET9/GFRalpha1/GDNF/FRS2 -0.046 0.14 -9999 0 -0.32 39 39
SHANK3 0.01 0.038 -9999 0 -0.54 1 1
RASA1 0.003 0.076 -9999 0 -0.62 3 3
NCK1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.021 0.099 -9999 0 -0.27 21 21
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.051 0.13 -9999 0 -0.41 8 8
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.055 0.14 -9999 0 -0.36 16 16
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.054 0.14 -9999 0 -0.48 8 8
PI3K -0.078 0.19 -9999 0 -0.62 11 11
SOS1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.038 0.13 -9999 0 -0.33 21 21
GRB10 -0.003 0.098 -9999 0 -0.62 5 5
activation of MAPKK activity -0.043 0.12 -9999 0 -0.37 8 8
RET51/GFRalpha1/GDNF/FRS2 -0.095 0.19 -9999 0 -0.42 32 32
GAB1 0.006 0.062 -9999 0 -0.62 2 2
IRS1 -0.012 0.12 -9999 0 -0.61 8 8
IRS2 -0.008 0.11 -9999 0 -0.59 7 7
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.057 0.14 -9999 0 -0.48 8 8
RET51/GFRalpha1/GDNF/PKC alpha -0.1 0.19 -9999 0 -0.43 34 34
GRB2 0.013 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GDNF -0.02 0.11 -9999 0 -0.54 9 9
RAC1 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 -0.11 0.2 -9999 0 -0.44 37 37
Rac1/GTP -0.089 0.13 -9999 0 -0.47 11 11
RET9/GFRalpha1/GDNF -0.06 0.15 -9999 0 -0.36 39 39
GFRalpha1/GDNF -0.071 0.17 -9999 0 -0.43 39 39
Ephrin B reverse signaling

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.003 0.076 -10000 0 -0.62 3 3
EPHB2 -0.024 0.15 -10000 0 -0.62 12 12
EFNB1 -0.022 0.14 -10000 0 -0.48 18 18
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.093 0.18 -10000 0 -0.64 10 10
Ephrin B2/EPHB1-2 -0.047 0.15 -10000 0 -0.34 41 41
neuron projection morphogenesis -0.094 0.16 -10000 0 -0.61 10 10
Ephrin B1/EPHB1-2/Tiam1 -0.08 0.2 -10000 0 -0.59 14 14
DNM1 -0.015 0.13 -10000 0 -0.62 9 9
cell-cell signaling 0 0.002 -10000 0 -10000 0 0
MAP2K4 -0.029 0.17 -10000 0 -0.63 15 15
YES1 -0.058 0.22 -10000 0 -0.88 14 14
Ephrin B1/EPHB1-2/NCK2 -0.056 0.17 -10000 0 -0.69 5 5
PI3K -0.039 0.2 -10000 0 -0.7 15 15
mol:GDP -0.08 0.2 -10000 0 -0.58 14 14
ITGA2B -0.049 0.18 -10000 0 -0.6 21 21
endothelial cell proliferation 0.008 0.049 -10000 0 -0.39 3 3
FYN -0.061 0.23 -10000 0 -0.9 14 14
MAP3K7 -0.046 0.18 -10000 0 -0.7 14 14
FGR -0.06 0.22 -10000 0 -0.88 14 14
TIAM1 -0.03 0.16 -10000 0 -0.62 14 14
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
RGS3 0.013 0 -10000 0 -10000 0 0
cell adhesion -0.1 0.24 -10000 0 -0.75 18 18
LYN -0.059 0.22 -10000 0 -0.88 14 14
Ephrin B1/EPHB1-2/Src Family Kinases -0.057 0.21 -10000 0 -0.83 14 14
Ephrin B1/EPHB1-2 -0.055 0.19 -10000 0 -0.76 14 14
SRC -0.058 0.22 -10000 0 -0.88 14 14
ITGB3 -0.084 0.22 -10000 0 -0.57 34 34
EPHB1 -0.066 0.2 -10000 0 -0.57 28 28
EPHB4 0.013 0 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.011 0.049 -10000 0 -0.39 3 3
alphaIIb/beta3 Integrin -0.097 0.21 -10000 0 -0.44 52 52
BLK -0.075 0.22 -10000 0 -0.89 14 14
HCK -0.066 0.22 -10000 0 -0.88 14 14
regulation of stress fiber formation 0.057 0.17 0.68 5 -10000 0 5
MAPK8 -0.035 0.19 -10000 0 -0.71 14 14
Ephrin B1/EPHB1-2/RGS3 -0.056 0.17 -10000 0 -0.38 31 31
endothelial cell migration -0.043 0.16 -10000 0 -0.58 16 16
NCK2 0.013 0 -10000 0 -10000 0 0
PTPN13 -0.042 0.19 -10000 0 -0.74 14 14
regulation of focal adhesion formation 0.057 0.17 0.68 5 -10000 0 5
chemotaxis 0.057 0.17 0.37 31 -10000 0 31
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
Rac1/GTP -0.097 0.17 -10000 0 -0.63 10 10
angiogenesis -0.054 0.19 -10000 0 -0.75 14 14
LCK -0.062 0.22 -10000 0 -0.88 14 14
EPHB forward signaling

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 -0.028 0.13 -10000 0 -0.39 23 23
cell-cell adhesion 0.085 0.14 0.49 10 -10000 0 10
Ephrin B/EPHB2/RasGAP -0.04 0.16 -10000 0 -0.36 31 31
ITSN1 0.01 0.044 -10000 0 -0.62 1 1
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
SHC1 0.013 0 -10000 0 -10000 0 0
Ephrin B1/EPHB3 -0.043 0.16 -10000 0 -0.43 28 28
Ephrin B1/EPHB1 -0.052 0.15 -10000 0 -0.37 37 37
HRAS/GDP -0.068 0.13 -10000 0 -0.44 11 11
Ephrin B/EPHB1/GRB7 -0.062 0.18 -10000 0 -0.4 31 31
Endophilin/SYNJ1 -0.035 0.14 -10000 0 -0.34 29 29
KRAS 0.01 0.038 -10000 0 -0.54 1 1
Ephrin B/EPHB1/Src -0.057 0.17 -10000 0 -0.38 31 31
endothelial cell migration -0.017 0.077 -10000 0 -0.37 6 6
GRB2 0.013 0 -10000 0 -10000 0 0
GRB7 0.004 0.073 -10000 0 -0.6 3 3
PAK1 -0.047 0.17 -10000 0 -0.59 8 8
HRAS 0.013 0 -10000 0 -10000 0 0
RRAS -0.034 0.14 -10000 0 -0.33 29 29
DNM1 -0.015 0.13 -10000 0 -0.62 9 9
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.054 0.16 -10000 0 -0.36 31 31
lamellipodium assembly -0.085 0.14 -10000 0 -0.49 10 10
Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.026 0.12 -10000 0 -0.3 19 19
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
EPHB2 -0.024 0.15 -10000 0 -0.62 12 12
EPHB3 -0.052 0.19 -10000 0 -0.62 21 21
EPHB1 -0.066 0.2 -10000 0 -0.57 28 28
EPHB4 0.013 0 -10000 0 -10000 0 0
mol:GDP -0.03 0.15 -10000 0 -0.4 15 15
Ephrin B/EPHB2 -0.043 0.15 -10000 0 -0.36 29 29
Ephrin B/EPHB3 -0.058 0.18 -10000 0 -0.4 34 34
JNK cascade -0.042 0.15 -10000 0 -0.75 2 2
Ephrin B/EPHB1 -0.064 0.17 -10000 0 -0.39 31 31
RAP1/GDP -0.048 0.12 -10000 0 -0.4 8 8
EFNB2 0.003 0.076 -10000 0 -0.62 3 3
EFNB3 -0.043 0.17 -10000 0 -0.56 20 20
EFNB1 -0.018 0.14 -10000 0 -0.62 10 10
Ephrin B2/EPHB1-2 -0.048 0.15 -10000 0 -0.34 41 41
RAP1B 0.013 0 -10000 0 -10000 0 0
RAP1A 0.01 0.044 -10000 0 -0.62 1 1
CDC42/GTP -0.092 0.15 -10000 0 -0.52 10 10
Rap1/GTP -0.086 0.14 -10000 0 -0.5 11 11
axon guidance -0.028 0.13 -10000 0 -0.39 23 23
MAPK3 -0.009 0.11 -10000 0 -0.43 3 3
MAPK1 -0.009 0.11 -10000 0 -0.43 3 3
Rac1/GDP -0.02 0.14 -10000 0 -0.39 11 11
actin cytoskeleton reorganization -0.065 0.11 -10000 0 -0.38 11 11
CDC42/GDP -0.02 0.14 -10000 0 -0.39 11 11
PI3K 0.011 0.084 -10000 0 -0.38 6 6
EFNA5 -0.021 0.14 -10000 0 -0.62 11 11
Ephrin B2/EPHB4 0.011 0.049 -10000 0 -0.39 3 3
Ephrin B/EPHB2/Intersectin/N-WASP -0.024 0.13 -10000 0 -0.29 30 30
CDC42 0.013 0 -10000 0 -10000 0 0
RAS family/GTP -0.084 0.14 -10000 0 -0.48 11 11
PTK2 0.019 0.035 -10000 0 -10000 0 0
MAP4K4 -0.043 0.16 -10000 0 -0.77 2 2
SRC 0.013 0 -10000 0 -10000 0 0
KALRN -0.026 0.15 -10000 0 -0.6 13 13
Intersectin/N-WASP 0.017 0.033 -10000 0 -0.46 1 1
neuron projection morphogenesis -0.036 0.15 -10000 0 -0.42 11 11
MAP2K1 -0.017 0.11 -10000 0 -0.46 3 3
WASL 0.013 0 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 -0.052 0.16 -10000 0 -0.38 29 29
cell migration -0.012 0.12 -10000 0 -0.44 4 4
NRAS 0.013 0 -10000 0 -10000 0 0
SYNJ1 -0.035 0.15 -10000 0 -0.34 29 29
PXN 0.013 0 -10000 0 -10000 0 0
TF -0.11 0.19 -10000 0 -0.6 13 13
HRAS/GTP -0.092 0.15 -10000 0 -0.53 10 10
Ephrin B1/EPHB1-2 -0.06 0.16 -10000 0 -0.35 47 47
cell adhesion mediated by integrin 0.055 0.13 0.36 26 -10000 0 26
RAC1 0.013 0 -10000 0 -10000 0 0
mol:GTP -0.071 0.18 -10000 0 -0.57 10 10
RAC1-CDC42/GTP -0.11 0.16 -10000 0 -0.5 20 20
RASA1 0.003 0.076 -10000 0 -0.62 3 3
RAC1-CDC42/GDP -0.046 0.12 -10000 0 -0.37 11 11
ruffle organization -0.045 0.16 -10000 0 -0.5 10 10
NCK1 0.013 0 -10000 0 -10000 0 0
receptor internalization -0.041 0.16 -10000 0 -0.62 7 7
Ephrin B/EPHB2/KALRN -0.056 0.18 -10000 0 -0.39 35 35
ROCK1 -0.031 0.14 -10000 0 -0.38 28 28
RAS family/GDP -0.063 0.11 -10000 0 -0.38 11 11
Rac1/GTP -0.09 0.15 -10000 0 -0.52 10 10
Ephrin B/EPHB1/Src/Paxillin -0.035 0.13 -10000 0 -0.3 31 31
IL6-mediated signaling events

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.078 0.26 -9999 0 -0.7 11 11
CRP -0.089 0.26 -9999 0 -0.7 13 13
cell cycle arrest -0.097 0.28 -9999 0 -0.66 21 21
TIMP1 -0.065 0.24 -9999 0 -0.67 13 13
IL6ST -0.085 0.23 -9999 0 -0.62 32 32
Rac1/GDP -0.07 0.19 -9999 0 -0.45 25 25
AP1 0 0.11 -9999 0 -0.38 5 5
GAB2 0.011 0.039 -9999 0 -0.54 1 1
TNFSF11 -0.14 0.37 -9999 0 -0.94 27 27
HSP90B1 0.017 0.051 -9999 0 -10000 0 0
GAB1 0.007 0.062 -9999 0 -0.62 2 2
MAPK14 -0.071 0.19 -9999 0 -0.58 16 16
AKT1 0.039 0.053 -9999 0 -10000 0 0
FOXO1 0.043 0.062 -9999 0 -0.51 1 1
MAP2K6 -0.084 0.2 -9999 0 -0.56 19 19
mol:GTP 0 0.002 -9999 0 -10000 0 0
MAP2K4 -0.066 0.21 -9999 0 -0.52 19 19
MITF -0.071 0.19 -9999 0 -0.49 20 20
positive regulation of NF-kappaB transcription factor activity 0 0 -9999 0 -10000 0 0
TYK2 0.013 0 -9999 0 -10000 0 0
A2M -0.006 0.18 -9999 0 -1.4 3 3
CEBPB 0.02 0.003 -9999 0 -10000 0 0
GRB2/SOS1/GAB family/SHP2 -0.006 0.086 -9999 0 -0.53 1 1
STAT3 -0.1 0.29 -9999 0 -0.7 21 21
STAT1 -0.006 0.02 -9999 0 -10000 0 0
CEBPD -0.075 0.25 -9999 0 -0.69 9 9
PIK3CA 0.011 0.044 -9999 0 -0.62 1 1
PI3K 0.002 0.089 -9999 0 -0.42 9 9
JUN 0.01 0.044 -9999 0 -0.62 1 1
PIAS3/MITF -0.061 0.18 -9999 0 -0.5 16 16
MAPK11 -0.077 0.2 -9999 0 -0.58 16 16
STAT3 (dimer)/FOXO1 -0.038 0.25 -9999 0 -0.66 10 10
GRB2/SOS1/GAB family -0.085 0.16 -9999 0 -0.55 14 14
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.083 0.21 -9999 0 -0.49 27 27
GRB2 0.013 0.002 -9999 0 -10000 0 0
JAK2 0.004 0.07 -9999 0 -0.57 3 3
LBP -0.067 0.24 -9999 0 -0.63 13 13
PIK3R1 -0.009 0.11 -9999 0 -0.57 8 8
JAK1 0.014 0.005 -9999 0 -10000 0 0
MYC -0.14 0.38 -9999 0 -0.97 27 27
FGG -0.098 0.27 -9999 0 -0.72 13 13
macrophage differentiation -0.097 0.28 -9999 0 -0.66 21 21
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.13 0.2 -9999 0 -0.51 27 27
JUNB -0.073 0.24 -9999 0 -0.66 9 9
FOS -0.041 0.17 -9999 0 -0.57 19 19
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.077 0.19 -9999 0 -0.47 25 25
STAT1/PIAS1 -0.064 0.18 -9999 0 -0.44 23 23
GRB2/SOS1/GAB family/SHP2/PI3K 0.028 0.054 -9999 0 -0.28 1 1
STAT3 (dimer) -0.1 0.29 -9999 0 -0.69 21 21
PRKCD -0.063 0.23 -9999 0 -0.58 15 15
IL6R -0.031 0.16 -9999 0 -0.6 15 15
SOCS3 -0.067 0.2 -9999 0 -0.85 6 6
gp130 (dimer)/JAK1/JAK1/LMO4 -0.038 0.16 -9999 0 -0.38 34 34
Rac1/GTP -0.072 0.2 -9999 0 -0.46 26 26
HCK -0.015 0.13 -9999 0 -0.62 9 9
MAPKKK cascade 0.012 0.074 -9999 0 -0.41 1 1
bone resorption -0.13 0.35 -9999 0 -0.87 27 27
IRF1 -0.091 0.29 -9999 0 -0.82 14 14
mol:GDP -0.078 0.19 -9999 0 -0.45 29 29
SOS1 0.013 0.003 -9999 0 -10000 0 0
VAV1 -0.08 0.2 -9999 0 -0.46 29 29
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.072 0.19 -9999 0 -0.61 15 15
PTPN11 -0.006 0.02 -9999 0 -10000 0 0
IL6/IL6RA -0.087 0.21 -9999 0 -0.45 47 47
gp130 (dimer)/TYK2/TYK2/LMO4 -0.041 0.15 -9999 0 -0.38 34 34
gp130 (dimer)/JAK2/JAK2/LMO4 -0.047 0.16 -9999 0 -0.39 36 36
IL6 -0.089 0.22 -9999 0 -0.56 37 37
PIAS3 0.013 0 -9999 0 -10000 0 0
PTPRE 0.001 0.072 -9999 0 -0.58 3 3
PIAS1 0.013 0 -9999 0 -10000 0 0
RAC1 0.013 0.001 -9999 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.078 0.18 -9999 0 -0.41 29 29
LMO4 0.009 0.057 -9999 0 -0.55 2 2
STAT3 (dimer)/PIAS3 -0.15 0.23 -9999 0 -0.66 20 20
MCL1 0.044 0.055 -9999 0 -10000 0 0
Osteopontin-mediated events

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.061 0.17 -9999 0 -0.5 9 9
NF kappa B1 p50/RelA/I kappa B alpha -0.037 0.16 -9999 0 -0.48 9 9
alphaV/beta3 Integrin/Osteopontin/Src -0.069 0.16 -9999 0 -0.4 36 36
AP1 -0.079 0.22 -9999 0 -0.51 27 27
ILK -0.07 0.18 -9999 0 -0.53 8 8
bone resorption -0.056 0.17 -9999 0 -0.52 11 11
PTK2B 0.013 0 -9999 0 -10000 0 0
PYK2/p130Cas -0.089 0.14 -9999 0 -0.54 7 7
ITGAV 0.009 0.062 -9999 0 -0.62 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 -0.011 0.11 -9999 0 -0.45 13 13
alphaV/beta3 Integrin/Osteopontin -0.11 0.18 -9999 0 -0.42 32 32
MAP3K1 -0.073 0.18 -9999 0 -0.38 30 30
JUN 0.01 0.044 -9999 0 -0.62 1 1
MAPK3 -0.062 0.17 -9999 0 -0.53 9 9
MAPK1 -0.062 0.17 -9999 0 -0.53 9 9
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
NFKB1 0.01 0.038 -9999 0 -0.54 1 1
MAPK8 -0.076 0.19 -9999 0 -0.54 13 13
ITGB3 -0.081 0.22 -9999 0 -0.57 34 34
NFKBIA -0.051 0.17 -9999 0 -0.53 9 9
FOS -0.041 0.17 -9999 0 -0.57 19 19
CD44 -0.002 0.095 -9999 0 -0.61 5 5
CHUK 0.013 0 -9999 0 -10000 0 0
PLAU -0.084 0.29 -9999 0 -1 14 14
NF kappa B1 p50/RelA -0.085 0.13 -9999 0 -0.5 9 9
BCAR1 0.013 0 -9999 0 -10000 0 0
RELA 0.013 0 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.069 0.17 -9999 0 -0.43 34 34
mol:GDP 0 0 -9999 0 -10000 0 0
SYK -0.075 0.18 -9999 0 -0.51 11 11
VAV3 -0.089 0.2 -9999 0 -0.57 17 17
MAP3K14 -0.073 0.18 -9999 0 -0.52 10 10
ROCK2 -0.012 0.12 -9999 0 -0.62 8 8
SPP1 -0.08 0.22 -9999 0 -0.56 34 34
RAC1 0.013 0 -9999 0 -10000 0 0
Rac1/GTP -0.076 0.19 -9999 0 -0.55 15 15
MMP2 -0.07 0.21 -9999 0 -0.52 21 21
Noncanonical Wnt signaling pathway

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 -0.051 0.19 -9999 0 -0.6 21 21
GNB1/GNG2 -0.072 0.17 -9999 0 -0.54 11 11
mol:DAG -0.059 0.15 -9999 0 -0.49 11 11
PLCG1 -0.061 0.16 -9999 0 -0.51 11 11
YES1 -0.08 0.17 -9999 0 -0.48 15 15
FZD3 -0.037 0.17 -9999 0 -0.59 17 17
FZD6 0.01 0.044 -9999 0 -0.62 1 1
G protein -0.062 0.16 -9999 0 -0.51 11 11
MAP3K7 -0.067 0.16 -9999 0 -0.45 14 14
mol:Ca2+ -0.057 0.15 -9999 0 -0.47 11 11
mol:IP3 -0.059 0.15 -9999 0 -0.49 11 11
NLK -0.005 0.008 -9999 0 -10000 0 0
GNB1 0.013 0 -9999 0 -10000 0 0
CAMK2A -0.079 0.17 -9999 0 -0.46 19 19
MAP3K7IP1 0 0 -9999 0 -10000 0 0
Noncanonical Wnts/FZD -0.093 0.18 -9999 0 -0.5 16 16
CSNK1A1 0.013 0 -9999 0 -10000 0 0
GNAS -0.08 0.17 -9999 0 -0.48 15 15
GO:0007205 -0.058 0.15 -9999 0 -0.48 11 11
WNT6 -0.043 0.17 -9999 0 -0.56 20 20
WNT4 -0.066 0.21 -9999 0 -0.61 26 26
NFAT1/CK1 alpha -0.087 0.18 -9999 0 -0.51 18 18
GNG2 0.01 0.038 -9999 0 -0.54 1 1
WNT5A -0.014 0.12 -9999 0 -0.6 9 9
WNT11 -0.086 0.22 -9999 0 -0.57 35 35
CDC42 -0.069 0.16 -9999 0 -0.51 11 11
Arf6 signaling events

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B -0.003 0.084 -9999 0 -0.36 11 11
ARNO/beta Arrestin1-2 -0.053 0.11 -9999 0 -0.52 2 2
EGFR -0.033 0.16 -9999 0 -0.62 15 15
EPHA2 -0.012 0.12 -9999 0 -0.62 8 8
USP6 0.01 0.038 -9999 0 -0.54 1 1
IQSEC1 0.013 0 -9999 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.084 0.19 -9999 0 -0.43 47 47
ARRB2 0.009 0.002 -9999 0 -10000 0 0
mol:GTP 0.008 0.036 -9999 0 -0.14 6 6
ARRB1 0.007 0.054 -9999 0 -0.54 2 2
FBXO8 0.013 0 -9999 0 -10000 0 0
TSHR -0.013 0.11 -9999 0 -0.54 9 9
EGF -0.081 0.21 -9999 0 -0.57 33 33
somatostatin receptor activity 0 0 -9999 0 -0.001 19 19
ARAP2 0.01 0.044 -9999 0 -0.62 1 1
mol:GDP -0.036 0.1 -9999 0 -0.32 15 15
mol:PI-3-4-5-P3 0 0 -9999 0 -0.001 9 9
ITGA2B -0.049 0.18 -9999 0 -0.6 21 21
ARF6 0.013 0 -9999 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.018 0.072 -9999 0 -0.34 8 8
ADAP1 -0.013 0.12 -9999 0 -0.58 9 9
KIF13B 0.007 0.058 -9999 0 -0.58 2 2
HGF/MET -0.037 0.15 -9999 0 -0.44 25 25
PXN 0.013 0 -9999 0 -10000 0 0
ARF6/GTP -0.047 0.11 -9999 0 -0.29 16 16
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.066 0.16 -9999 0 -0.36 47 47
ADRB2 -0.1 0.24 -9999 0 -0.61 38 38
receptor agonist activity 0 0 -9999 0 0 17 17
actin filament binding 0 0 -9999 0 -0.001 19 19
SRC 0.013 0 -9999 0 -10000 0 0
ITGB3 -0.084 0.22 -9999 0 -0.57 34 34
GNAQ 0.009 0.044 -9999 0 -0.62 1 1
EFA6/PI-4-5-P2 0 0 -9999 0 -0.001 12 12
ARF6/GDP 0.007 0.099 -9999 0 -0.39 7 7
ARF6/GDP/GULP/ACAP1 -0.087 0.14 -9999 0 -0.32 45 45
alphaIIb/beta3 Integrin/paxillin/GIT1 -0.059 0.16 -9999 0 -0.38 26 26
ACAP1 -0.02 0.14 -9999 0 -0.6 11 11
ACAP2 0.01 0.044 -9999 0 -0.62 1 1
LHCGR/beta Arrestin2 0.001 0.004 -9999 0 -10000 0 0
EFNA1 0.013 0 -9999 0 -10000 0 0
HGF -0.038 0.17 -9999 0 -0.59 17 17
CYTH3 0.009 0.028 -9999 0 -0.39 1 1
CYTH2 0.008 0.002 -9999 0 -10000 0 0
NCK1 0.013 0 -9999 0 -10000 0 0
fibronectin binding 0 0 -9999 0 0 20 20
endosomal lumen acidification 0 0 -9999 0 0 13 13
microtubule-based process 0 0 -9999 0 -10000 0 0
GULP1 -0.079 0.22 -9999 0 -0.62 30 30
GNAQ/ARNO 0.013 0.024 -9999 0 -10000 0 0
mol:Phosphatidic acid 0 0 -9999 0 -10000 0 0
PIP3-E 0 0 -9999 0 0 13 13
MET -0.012 0.12 -9999 0 -0.62 8 8
GNA14 -0.063 0.2 -9999 0 -0.56 27 27
GNA15 -0.039 0.17 -9999 0 -0.62 17 17
GIT1 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -0.001 12 12
GNA11 -0.009 0.12 -9999 0 -0.62 7 7
LHCGR 0.001 0.003 -9999 0 -10000 0 0
AGTR1 -0.032 0.15 -9999 0 -0.55 16 16
desensitization of G-protein coupled receptor protein signaling pathway 0.001 0.004 -9999 0 -10000 0 0
IPCEF1/ARNO -0.048 0.13 -9999 0 -0.54 1 1
alphaIIb/beta3 Integrin -0.097 0.21 -9999 0 -0.44 52 52
LPA receptor mediated events

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0 0.094 -9999 0 -0.43 6 6
NF kappa B1 p50/RelA/I kappa B alpha -0.026 0.14 -9999 0 -0.45 9 9
AP1 -0.086 0.16 -9999 0 -0.51 14 14
mol:PIP3 -0.084 0.17 -9999 0 -0.58 13 13
AKT1 0.026 0.084 -9999 0 -0.36 4 4
PTK2B -0.003 0.074 -9999 0 -0.33 5 5
RHOA 0.023 0.045 -9999 0 -0.35 1 1
PIK3CB 0.013 0.001 -9999 0 -10000 0 0
mol:Ca2+ -0.038 0.15 -9999 0 -0.47 12 12
MAGI3 0.006 0.062 -9999 0 -0.62 2 2
RELA 0.013 0 -9999 0 -10000 0 0
apoptosis -0.044 0.15 -9999 0 -0.36 34 34
HRAS/GDP 0.009 0 -9999 0 -10000 0 0
positive regulation of microtubule depolymerization -0.026 0.12 -9999 0 -0.34 14 14
NF kappa B1 p50/RelA -0.067 0.15 -9999 0 -0.52 11 11
endothelial cell migration -0.016 0.16 -9999 0 -0.53 16 16
ADCY4 -0.025 0.14 -9999 0 -0.48 11 11
ADCY5 -0.059 0.16 -9999 0 -0.43 20 20
ADCY6 -0.024 0.14 -9999 0 -0.46 12 12
ADCY7 -0.023 0.14 -9999 0 -0.47 11 11
ADCY1 -0.035 0.15 -9999 0 -0.44 15 15
ADCY2 -0.051 0.17 -9999 0 -0.48 18 18
ADCY3 -0.022 0.14 -9999 0 -0.47 11 11
ADCY8 -0.026 0.14 -9999 0 -0.47 11 11
ADCY9 -0.023 0.14 -9999 0 -0.49 11 11
GSK3B 0.004 0.071 -9999 0 -0.35 3 3
arachidonic acid secretion -0.015 0.13 -9999 0 -0.44 11 11
GNG2 0.01 0.038 -9999 0 -0.54 1 1
TRIP6 0.017 0.045 -9999 0 -0.42 2 2
GNAO1 -0.017 0.13 -9999 0 -0.41 18 18
HRAS 0.013 0 -9999 0 -10000 0 0
NFKBIA -0.034 0.16 -9999 0 -0.5 12 12
GAB1 0.006 0.062 -9999 0 -0.62 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
lamellipodium assembly -0.058 0.22 -9999 0 -0.89 14 14
JUN 0.009 0.044 -9999 0 -0.62 1 1
LPA/LPA2/NHERF2 -0.008 0.041 -9999 0 -0.32 3 3
TIAM1 -0.07 0.27 -9999 0 -1.1 14 14
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
mol:IP3 -0.039 0.15 -9999 0 -0.48 12 12
PLCB3 0.018 0.041 -9999 0 -0.28 3 3
FOS -0.041 0.17 -9999 0 -0.57 19 19
positive regulation of mitosis -0.015 0.13 -9999 0 -0.44 11 11
LPA/LPA1-2-3 -0.05 0.16 -9999 0 -0.38 35 35
mol:Ca ++ 0 0 -9999 0 -10000 0 0
JNK cascade 0 0.001 -9999 0 -10000 0 0
BCAR1 0.013 0 -9999 0 -10000 0 0
stress fiber formation -0.01 0.1 -9999 0 -0.39 6 6
GNAZ -0.042 0.15 -9999 0 -0.37 33 33
EGFR/PI3K-beta/Gab1 -0.088 0.18 -9999 0 -0.62 13 13
positive regulation of dendritic cell cytokine production -0.071 0.15 -9999 0 -0.38 35 35
LPA/LPA2/MAGI-3 -0.005 0.041 -9999 0 -0.38 2 2
ARHGEF1 0.015 0.083 -9999 0 -0.35 6 6
GNAI2 0 0.096 -9999 0 -0.36 11 11
GNAI3 0 0.096 -9999 0 -0.36 11 11
GNAI1 -0.021 0.14 -9999 0 -0.4 21 21
LPA/LPA3 -0.071 0.16 -9999 0 -0.46 30 30
LPA/LPA2 -0.004 0.022 -9999 0 -10000 0 0
LPA/LPA1 -0.029 0.11 -9999 0 -0.38 16 16
HB-EGF/EGFR -0.063 0.16 -9999 0 -0.36 45 45
HBEGF -0.044 0.16 -9999 0 -0.43 30 30
mol:DAG -0.039 0.15 -9999 0 -0.48 12 12
cAMP biosynthetic process -0.036 0.15 -9999 0 -0.48 13 13
NFKB1 0.01 0.038 -9999 0 -0.54 1 1
SRC 0.013 0 -9999 0 -10000 0 0
GNB1 0.013 0.001 -9999 0 -10000 0 0
LYN -0.036 0.16 -9999 0 -0.5 12 12
GNAQ -0.032 0.13 -9999 0 -0.34 30 30
LPAR2 0.013 0.001 -9999 0 -10000 0 0
LPAR3 -0.08 0.22 -9999 0 -0.62 30 30
LPAR1 -0.012 0.12 -9999 0 -0.63 7 7
IL8 -0.12 0.22 -9999 0 -0.46 50 50
PTK2 -0.036 0.15 -9999 0 -0.35 34 34
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
CASP3 -0.044 0.15 -9999 0 -0.36 34 34
EGFR -0.034 0.16 -9999 0 -0.62 15 15
PLCG1 -0.056 0.16 -9999 0 -0.41 30 30
PLD2 -0.036 0.15 -9999 0 -0.35 34 34
G12/G13 0.004 0.088 -9999 0 -0.37 7 7
PI3K-beta -0.025 0.078 -9999 0 -0.42 4 4
cell migration -0.032 0.081 -9999 0 -0.26 15 15
SLC9A3R2 0.005 0.066 -9999 0 -0.54 3 3
PXN -0.011 0.1 -9999 0 -0.4 6 6
HRAS/GTP -0.016 0.14 -9999 0 -0.45 11 11
RAC1 0.013 0 -9999 0 -10000 0 0
MMP9 -0.067 0.2 -9999 0 -0.59 27 27
PRKCE 0.013 0 -9999 0 -10000 0 0
PRKCD -0.03 0.14 -9999 0 -0.45 12 12
Gi(beta/gamma) -0.018 0.13 -9999 0 -0.45 11 11
mol:LPA -0.004 0.038 -9999 0 -0.2 4 4
TRIP6/p130 Cas/FAK1/Paxillin -0.052 0.14 -9999 0 -0.55 6 6
MAPKKK cascade -0.015 0.13 -9999 0 -0.44 11 11
contractile ring contraction involved in cytokinesis 0.023 0.045 -9999 0 -0.35 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
GNA14 -0.067 0.16 -9999 0 -0.35 42 42
GNA15 -0.06 0.17 -9999 0 -0.38 41 41
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
MAPT -0.027 0.12 -9999 0 -0.35 14 14
GNA11 -0.043 0.15 -9999 0 -0.36 34 34
Rac1/GTP -0.041 0.24 -9999 0 -0.95 14 14
MMP2 -0.016 0.16 -9999 0 -0.53 16 16
LPA4-mediated signaling events

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 0.011 0.052 -9999 0 -0.36 4 4
ADCY5 -0.078 0.16 -9999 0 -0.35 54 54
ADCY6 0.014 0.04 -9999 0 -0.39 2 2
ADCY7 0.016 0.028 -9999 0 -0.39 1 1
ADCY1 -0.014 0.11 -9999 0 -0.36 18 18
ADCY2 -0.058 0.15 -9999 0 -0.35 43 43
ADCY3 0.018 0 -9999 0 -10000 0 0
ADCY8 0.009 0.024 -9999 0 -0.33 1 1
PRKCE 0.011 0 -9999 0 -10000 0 0
ADCY9 0.016 0.028 -9999 0 -0.39 1 1
mol:DAG 0 0 -9999 0 -10000 0 0
cAMP biosynthetic process -0.031 0.089 -9999 0 -0.3 8 8
Caspase cascade in apoptosis

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.026 0.17 -10000 0 -0.45 23 23
ACTA1 -0.049 0.22 -10000 0 -0.59 23 23
NUMA1 -0.026 0.17 -10000 0 -0.44 24 24
SPTAN1 -0.044 0.21 -10000 0 -0.59 23 23
LIMK1 -0.044 0.21 -10000 0 -0.59 23 23
BIRC3 -0.038 0.16 -10000 0 -0.56 18 18
BIRC2 -0.014 0.12 -10000 0 -0.54 10 10
BAX 0.013 0 -10000 0 -10000 0 0
CASP10 -0.059 0.22 -10000 0 -0.55 31 31
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0.013 0 -10000 0 -10000 0 0
PTK2 -0.026 0.17 -10000 0 -0.45 23 23
DIABLO 0.013 0 -10000 0 -10000 0 0
apoptotic nuclear changes -0.043 0.21 -10000 0 -0.57 23 23
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.013 0 -10000 0 -10000 0 0
GSN -0.044 0.21 -10000 0 -0.59 23 23
MADD 0.013 0 -10000 0 -10000 0 0
TFAP2A -0.025 0.16 -10000 0 -0.66 11 11
BID -0.018 0.11 -10000 0 -0.3 24 24
MAP3K1 -0.007 0.075 -10000 0 -0.24 12 12
TRADD 0.013 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.016 0.033 -10000 0 -0.45 1 1
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.049 0.23 -10000 0 -0.61 24 24
CASP9 0.013 0.001 -10000 0 -10000 0 0
DNA repair -0.001 0.058 0.19 2 -0.18 3 5
neuron apoptosis 0.015 0.043 -10000 0 -0.51 1 1
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.037 0.21 -10000 0 -0.56 23 23
APAF1 0.01 0.044 -10000 0 -0.62 1 1
CASP6 -0.001 0.1 -10000 0 -0.35 11 11
TRAF2 0.013 0 -10000 0 -10000 0 0
ICAD/CAD -0.038 0.21 -10000 0 -0.56 23 23
CASP7 0.011 0.068 0.31 5 -10000 0 5
KRT18 -0.006 0.086 -10000 0 -0.55 4 4
apoptosis -0.026 0.18 -10000 0 -0.51 21 21
DFFA -0.044 0.21 -10000 0 -0.59 23 23
DFFB -0.046 0.21 -10000 0 -0.57 24 24
PARP1 0.001 0.058 0.18 3 -0.2 2 5
actin filament polymerization 0.033 0.2 0.53 23 -10000 0 23
TNF -0.041 0.17 -10000 0 -0.57 19 19
CYCS -0.011 0.079 -10000 0 -0.25 15 15
SATB1 -0.002 0.11 -10000 0 -0.43 4 4
SLK -0.044 0.21 -10000 0 -0.59 23 23
p15 BID/BAX -0.01 0.1 -10000 0 -0.35 10 10
CASP2 0.02 0.072 -10000 0 -0.38 1 1
JNK cascade 0.007 0.074 0.23 12 -10000 0 12
CASP3 -0.054 0.22 -10000 0 -0.61 24 24
LMNB2 0.019 0.067 -10000 0 -0.32 3 3
RIPK1 0.013 0 -10000 0 -10000 0 0
CASP4 0.007 0.058 -10000 0 -0.58 2 2
Mammalian IAPs/DIABLO -0.012 0.14 -10000 0 -0.48 12 12
negative regulation of DNA binding -0.024 0.16 -10000 0 -0.66 11 11
stress fiber formation -0.043 0.21 -10000 0 -0.57 23 23
GZMB -0.067 0.23 -10000 0 -0.61 29 29
CASP1 -0.01 0.11 -10000 0 -0.4 13 13
LMNB1 0.018 0.069 -10000 0 -0.32 3 3
APP 0.015 0.043 -10000 0 -0.51 1 1
TNFRSF1A 0.013 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 0.008 0.033 -10000 0 -0.46 1 1
VIM -0.029 0.18 0.22 2 -0.48 23 25
LMNA 0.019 0.067 -10000 0 -0.32 3 3
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.013 0.077 -10000 0 -0.41 1 1
LRDD 0.013 0 -10000 0 -10000 0 0
SREBF1 -0.044 0.21 -10000 0 -0.59 23 23
APAF-1/Caspase 9 0.011 0.085 0.38 7 -10000 0 7
nuclear fragmentation during apoptosis -0.025 0.16 -10000 0 -0.44 24 24
CFL2 -0.035 0.2 -10000 0 -0.55 23 23
GAS2 -0.094 0.25 -10000 0 -0.57 33 33
positive regulation of apoptosis 0.022 0.067 -10000 0 -0.34 2 2
PRF1 -0.038 0.17 -10000 0 -0.6 17 17
Coregulation of Androgen receptor activity

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.004 0.062 -9999 0 -0.62 2 2
SVIL 0.005 0.063 -9999 0 -0.63 2 2
ZNF318 0.015 0.045 -9999 0 -0.57 1 1
JMJD2C -0.005 0.028 -9999 0 -0.09 20 20
T-DHT/AR/Ubc9 -0.067 0.14 -9999 0 -0.35 38 38
CARM1 0.012 0.001 -9999 0 -10000 0 0
PRDX1 0.013 0.001 -9999 0 -10000 0 0
PELP1 0.013 0.003 -9999 0 -10000 0 0
CTNNB1 0.012 0.004 -9999 0 -10000 0 0
AKT1 0.014 0.006 -9999 0 -10000 0 0
PTK2B 0.012 0.004 -9999 0 -10000 0 0
MED1 0.014 0.006 -9999 0 -10000 0 0
MAK -0.1 0.23 -9999 0 -0.55 44 44
response to oxidative stress 0 0.001 -9999 0 -10000 0 0
HIP1 -0.014 0.12 -9999 0 -0.63 8 8
GSN 0.011 0.008 -9999 0 -10000 0 0
NCOA2 -0.059 0.2 -9999 0 -0.62 23 23
NCOA6 0.009 0.045 -9999 0 -0.64 1 1
DNA-PK 0.025 0.026 -9999 0 -10000 0 0
NCOA4 0.012 0.001 -9999 0 -10000 0 0
PIAS3 0.012 0.004 -9999 0 -10000 0 0
cell proliferation -0.092 0.17 -9999 0 -0.4 37 37
XRCC5 0.014 0.004 -9999 0 -10000 0 0
UBE3A 0.01 0.012 -9999 0 -10000 0 0
T-DHT/AR/SNURF -0.12 0.2 -9999 0 -0.42 58 58
FHL2 -0.034 0.19 -9999 0 -1.1 6 6
RANBP9 0.012 0.004 -9999 0 -10000 0 0
JMJD1A -0.02 0.062 -9999 0 -0.13 47 47
CDK6 -0.012 0.12 -9999 0 -0.62 8 8
TGFB1I1 -0.004 0.098 -9999 0 -0.62 5 5
T-DHT/AR/CyclinD1 -0.096 0.18 -9999 0 -0.38 51 51
XRCC6 0.014 0.004 -9999 0 -10000 0 0
T-DHT/AR -0.083 0.16 -9999 0 -0.36 41 41
CTDSP1 0.012 0.004 -9999 0 -10000 0 0
CTDSP2 0.016 0.014 -9999 0 -10000 0 0
BRCA1 0.011 0.006 -9999 0 -10000 0 0
TCF4 -0.002 0.1 -9999 0 -0.6 6 6
CDKN2A -0.01 0.12 -9999 0 -0.62 8 8
SRF 0.018 0.025 -9999 0 -10000 0 0
NKX3-1 -0.078 0.2 -9999 0 -0.84 9 9
KLK3 -0.016 0.13 -9999 0 -10000 0 0
TMF1 0.012 0.004 -9999 0 -10000 0 0
HNRNPA1 0.014 0.006 -9999 0 -10000 0 0
AOF2 -0.002 0.008 -9999 0 -10000 0 0
APPL1 0.025 0.013 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 -0.067 0.15 -9999 0 -0.36 39 39
AR -0.11 0.22 -9999 0 -0.57 38 38
UBA3 0.012 0.004 -9999 0 -10000 0 0
PATZ1 0.011 0.045 -9999 0 -0.62 1 1
PAWR 0.012 0.004 -9999 0 -10000 0 0
PRKDC 0.014 0.004 -9999 0 -10000 0 0
PA2G4 0.015 0.008 -9999 0 -10000 0 0
UBE2I 0.013 0 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 -0.059 0.13 -9999 0 -0.32 38 38
RPS6KA3 0.011 0.008 -9999 0 -10000 0 0
T-DHT/AR/ARA70 -0.068 0.14 -9999 0 -0.35 38 38
LATS2 0.014 0.007 -9999 0 -10000 0 0
T-DHT/AR/PRX1 -0.058 0.13 -9999 0 -0.32 38 38
Cyclin D3/CDK11 p58 0.01 0.001 -9999 0 -10000 0 0
VAV3 -0.038 0.17 -9999 0 -0.62 16 16
KLK2 -0.077 0.13 -9999 0 -0.53 5 5
CASP8 0.01 0.044 -9999 0 -0.62 1 1
T-DHT/AR/TIF2/CARM1 -0.095 0.17 -9999 0 -0.38 43 43
TMPRSS2 -0.19 0.38 -9999 0 -0.9 41 41
CCND1 -0.034 0.16 -9999 0 -0.58 16 16
PIAS1 0.01 0.012 -9999 0 -10000 0 0
mol:T-DHT -0.015 0.033 -9999 0 -0.072 41 41
CDC2L1 0 0.001 -9999 0 -10000 0 0
PIAS4 0.008 0.018 -9999 0 -10000 0 0
T-DHT/AR/CDK6 -0.082 0.17 -9999 0 -0.38 43 43
CMTM2 -0.022 0.14 -9999 0 -0.59 12 12
SNURF -0.073 0.21 -9999 0 -0.61 28 28
ZMIZ1 -0.004 0.055 -9999 0 -0.66 1 1
CCND3 0.013 0.001 -9999 0 -10000 0 0
TGIF1 0.014 0.006 -9999 0 -10000 0 0
FKBP4 0.012 0.004 -9999 0 -10000 0 0
Fc-epsilon receptor I signaling in mast cells

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.01 0.038 -9999 0 -0.54 1 1
LAT2 -0.053 0.16 -9999 0 -0.47 16 16
AP1 -0.11 0.18 -9999 0 -0.53 22 22
mol:PIP3 -0.068 0.21 -9999 0 -0.56 20 20
IKBKB -0.028 0.12 -9999 0 -0.32 16 16
AKT1 -0.064 0.17 -9999 0 -0.49 13 13
IKBKG -0.028 0.12 -9999 0 -0.31 18 18
MS4A2 -0.045 0.18 -9999 0 -0.6 19 19
mol:Sphingosine-1-phosphate 0 0 -9999 0 -10000 0 0
PIK3CA 0.009 0.044 -9999 0 -0.62 1 1
MAP3K1 -0.036 0.16 -9999 0 -0.47 17 17
mol:Ca2+ -0.046 0.15 -9999 0 -0.4 20 20
LYN 0.008 0.045 -9999 0 -0.64 1 1
CBLB -0.052 0.15 -9999 0 -0.47 15 15
SHC1 0.013 0 -9999 0 -10000 0 0
RasGAP/p62DOK 0.008 0.076 -9999 0 -0.33 10 10
positive regulation of cell migration 0 0 -9999 0 -10000 0 0
INPP5D 0.006 0.062 -9999 0 -0.62 2 2
PLD2 -0.087 0.19 -9999 0 -0.54 14 14
PTPN13 -0.062 0.17 -9999 0 -0.52 15 15
PTPN11 0.009 0.008 -9999 0 -10000 0 0
GO:0007205 0 0 -9999 0 -10000 0 0
regulation of mast cell degranulation -0.028 0.14 -9999 0 -0.36 12 12
SYK 0.005 0.063 -9999 0 -0.63 2 2
GRB2 0.012 0.001 -9999 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.11 0.19 -9999 0 -0.59 20 20
LAT -0.058 0.17 -9999 0 -0.53 15 15
PAK2 -0.048 0.18 -9999 0 -0.51 19 19
NFATC2 -0.09 0.17 -9999 0 -0.58 19 19
HRAS -0.06 0.2 -9999 0 -0.57 19 19
GAB2 0.01 0.038 -9999 0 -0.54 1 1
PLA2G1B 0.031 0.019 -9999 0 -10000 0 0
Fc epsilon R1 -0.13 0.2 -9999 0 -0.43 52 52
Antigen/IgE/Fc epsilon R1 -0.12 0.19 -9999 0 -0.4 52 52
mol:GDP -0.072 0.21 -9999 0 -0.63 19 19
JUN 0.01 0.044 -9999 0 -0.62 1 1
mol:Ca++ 0 0 -9999 0 -10000 0 0
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
FOS -0.041 0.17 -9999 0 -0.57 19 19
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.061 0.16 -9999 0 -0.42 23 23
CHUK -0.028 0.12 -9999 0 -0.31 18 18
KLRG1 -0.056 0.15 -9999 0 -0.48 13 13
VAV1 -0.063 0.18 -9999 0 -0.53 18 18
calcium-dependent protein kinase C activity 0 0 -9999 0 -10000 0 0
CBL -0.054 0.15 -9999 0 -0.46 15 15
negative regulation of mast cell degranulation -0.048 0.15 -9999 0 -0.47 13 13
BTK -0.079 0.23 -9999 0 -0.61 23 23
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.085 0.2 -9999 0 -0.59 17 17
GAB2/PI3K/SHP2 -0.11 0.16 -9999 0 -0.54 13 13
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.064 0.16 -9999 0 -0.5 17 17
RAF1 0.021 0.022 -9999 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP -0.13 0.21 -9999 0 -0.67 16 16
FCER1G -0.014 0.13 -9999 0 -0.61 9 9
FCER1A -0.14 0.26 -9999 0 -0.59 50 50
Antigen/IgE/Fc epsilon R1/Fyn -0.12 0.18 -9999 0 -0.42 37 37
MAPK3 0.03 0.019 -9999 0 -10000 0 0
MAPK1 0.03 0.019 -9999 0 -10000 0 0
NFKB1 0.01 0.038 -9999 0 -0.54 1 1
MAPK8 -0.026 0.14 -9999 0 -0.59 10 10
DUSP1 -0.007 0.11 -9999 0 -0.57 7 7
NF-kappa-B/RelA -0.036 0.057 -9999 0 -0.24 1 1
actin cytoskeleton reorganization -0.049 0.15 -9999 0 -0.49 13 13
mol:Glucocorticoid Dexamethasone 0 0 -9999 0 -10000 0 0
PI3K -0.092 0.16 -9999 0 -0.52 19 19
FER -0.055 0.16 -9999 0 -0.49 14 14
RELA 0.013 0 -9999 0 -10000 0 0
ITK -0.047 0.12 -9999 0 -0.5 13 13
SOS1 0.013 0 -9999 0 -10000 0 0
PLCG1 -0.069 0.21 -9999 0 -0.61 20 20
cytokine secretion -0.027 0.041 -9999 0 -10000 0 0
SPHK1 -0.057 0.16 -9999 0 -0.49 14 14
PTK2 -0.051 0.16 -9999 0 -0.51 13 13
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.11 0.19 -9999 0 -0.6 20 20
EDG1 0 0 -9999 0 -10000 0 0
mol:DAG -0.063 0.2 -9999 0 -0.54 20 20
MAP2K2 0.026 0.019 -9999 0 -10000 0 0
MAP2K1 0.026 0.019 -9999 0 -10000 0 0
MAP2K7 0.013 0 -9999 0 -10000 0 0
KLRG1/SHP2 -0.074 0.13 -9999 0 -0.44 13 13
MAP2K4 0.012 0.075 -9999 0 -1.1 1 1
Fc epsilon R1/FcgammaRIIB -0.14 0.22 -9999 0 -0.47 44 44
mol:Choline -0.085 0.18 -9999 0 -0.53 14 14
SHC/Grb2/SOS1 -0.067 0.12 -9999 0 -0.45 13 13
FYN -0.001 0.088 -9999 0 -0.56 5 5
DOK1 0.013 0 -9999 0 -10000 0 0
PXN -0.041 0.15 -9999 0 -0.48 12 12
HCLS1 -0.063 0.17 -9999 0 -0.5 18 18
PRKCB -0.053 0.17 -9999 0 -0.44 20 20
FCGR2B -0.027 0.15 -9999 0 -0.61 13 13
IGHE -0.002 0.006 -9999 0 -10000 0 0
KLRG1/SHIP -0.049 0.15 -9999 0 -0.48 13 13
LCP2 0 0.085 -9999 0 -0.6 4 4
PLA2G4A -0.099 0.19 -9999 0 -0.43 36 36
RASA1 0.003 0.076 -9999 0 -0.62 3 3
mol:Phosphatidic acid -0.085 0.18 -9999 0 -0.53 14 14
IKK complex -0.008 0.094 -9999 0 -0.26 9 9
WIPF1 -0.005 0.1 -9999 0 -0.6 6 6
PDGFR-alpha signaling pathway

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.036 0.16 -9999 0 -0.6 16 16
PDGF/PDGFRA/CRKL -0.016 0.12 -9999 0 -0.42 16 16
positive regulation of JUN kinase activity 0.005 0.09 -9999 0 -0.32 11 11
CRKL 0.013 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 -0.026 0.12 -9999 0 -0.43 17 17
AP1 -0.08 0.21 -9999 0 -0.64 19 19
mol:IP3 -0.015 0.12 -9999 0 -0.43 16 16
PLCG1 -0.015 0.12 -9999 0 -0.43 16 16
PDGF/PDGFRA/alphaV Integrin -0.02 0.13 -9999 0 -0.42 18 18
RAPGEF1 0.013 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ -0.015 0.12 -9999 0 -0.43 16 16
CAV3 -0.001 0.038 -9999 0 -0.54 1 1
CAV1 -0.016 0.13 -9999 0 -0.57 10 10
SHC/Grb2/SOS1 0.006 0.091 -9999 0 -0.32 11 11
PDGF/PDGFRA/Shf -0.032 0.15 -9999 0 -0.46 22 22
FOS -0.044 0.22 -9999 0 -0.63 19 19
JUN -0.009 0.035 -9999 0 -0.46 1 1
oligodendrocyte development -0.02 0.12 -9999 0 -0.42 18 18
GRB2 0.013 0 -9999 0 -10000 0 0
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
mol:DAG -0.015 0.12 -9999 0 -0.43 16 16
PDGF/PDGFRA -0.036 0.16 -9999 0 -0.6 16 16
actin cytoskeleton reorganization -0.018 0.12 -9999 0 -0.42 17 17
SRF 0.022 0.007 -9999 0 -10000 0 0
SHC1 0.013 0 -9999 0 -10000 0 0
PI3K -0.02 0.13 -9999 0 -0.38 23 23
PDGF/PDGFRA/Crk/C3G -0.004 0.1 -9999 0 -0.35 16 16
JAK1 -0.013 0.12 -9999 0 -0.42 16 16
ELK1/SRF 0.01 0.09 -9999 0 -10000 0 0
SHB 0.01 0.044 -9999 0 -0.62 1 1
SHF -0.011 0.12 -9999 0 -0.59 8 8
CSNK2A1 0.007 0.016 -9999 0 -10000 0 0
GO:0007205 -0.015 0.12 -9999 0 -0.43 16 16
SOS1 0.013 0 -9999 0 -10000 0 0
Ras protein signal transduction 0.005 0.09 -9999 0 -0.32 11 11
PDGF/PDGFRA/SHB -0.018 0.12 -9999 0 -0.42 17 17
PDGF/PDGFRA/Caveolin-1 -0.037 0.15 -9999 0 -0.43 25 25
ITGAV 0.006 0.062 -9999 0 -0.62 2 2
ELK1 -0.007 0.11 -9999 0 -0.4 12 12
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
PDGF/PDGFRA/Crk -0.016 0.12 -9999 0 -0.42 16 16
JAK-STAT cascade -0.013 0.12 -9999 0 -0.42 16 16
cell proliferation -0.032 0.15 -9999 0 -0.46 22 22
Reelin signaling pathway

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.01 0.063 -9999 0 -0.44 4 4
VLDLR -0.015 0.13 -9999 0 -0.61 9 9
CRKL 0.013 0 -9999 0 -10000 0 0
LRPAP1 0.013 0 -9999 0 -10000 0 0
FYN -0.001 0.088 -9999 0 -0.56 5 5
ITGA3 -0.015 0.13 -9999 0 -0.61 9 9
RELN/VLDLR/Fyn -0.057 0.17 -9999 0 -0.38 42 42
MAPK8IP1/MKK7/MAP3K11/JNK1 -0.002 0.11 -9999 0 -0.59 1 1
AKT1 -0.03 0.12 -9999 0 -0.41 5 5
MAP2K7 0.013 0 -9999 0 -10000 0 0
RAPGEF1 0.013 0 -9999 0 -10000 0 0
DAB1 -0.015 0.11 -9999 0 -0.54 8 8
RELN/LRP8/DAB1 -0.051 0.15 -9999 0 -0.34 40 40
LRPAP1/LRP8 0.01 0.065 -9999 0 -0.46 4 4
RELN/LRP8/DAB1/Fyn -0.048 0.15 -9999 0 -0.39 22 22
DAB1/alpha3/beta1 Integrin -0.079 0.15 -9999 0 -0.56 9 9
long-term memory -0.11 0.19 -9999 0 -0.58 15 15
DAB1/LIS1 -0.07 0.14 -9999 0 -0.58 6 6
DAB1/CRLK/C3G -0.066 0.13 -9999 0 -0.56 6 6
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
DAB1/NCK2 -0.07 0.14 -9999 0 -0.59 6 6
ARHGEF2 0.013 0 -9999 0 -10000 0 0
mol:Src family inhibitors PP1 and PP2 0 0 -9999 0 -10000 0 0
GRIN2A -0.12 0.24 -9999 0 -0.56 49 49
CDK5R1 0.001 0.085 -9999 0 -0.6 4 4
RELN -0.078 0.21 -9999 0 -0.58 31 31
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
RELN/LRP8/Fyn -0.048 0.16 -9999 0 -0.37 38 38
GRIN2A/RELN/LRP8/DAB1/Fyn -0.11 0.2 -9999 0 -0.59 14 14
MAPK8 -0.015 0.13 -9999 0 -0.62 9 9
RELN/VLDLR/DAB1 -0.06 0.16 -9999 0 -0.35 44 44
ITGB1 0.013 0 -9999 0 -10000 0 0
MAP1B -0.079 0.18 -9999 0 -0.52 16 16
RELN/LRP8 -0.04 0.15 -9999 0 -0.37 34 34
GRIN2B/RELN/LRP8/DAB1/Fyn -0.053 0.16 -9999 0 -0.68 5 5
PI3K 0 0.089 -9999 0 -0.42 9 9
mol:PP2 0 0 -9999 0 -10000 0 0
alpha3/beta1 Integrin -0.001 0.095 -9999 0 -0.45 9 9
RAP1A -0.025 0.14 -9999 0 -0.52 6 6
PAFAH1B1 0.013 0 -9999 0 -10000 0 0
MAPK8IP1 -0.031 0.16 -9999 0 -0.59 15 15
CRLK/C3G 0.019 0 -9999 0 -10000 0 0
GRIN2B -0.008 0.075 -9999 0 -0.54 4 4
NCK2 0.013 0 -9999 0 -10000 0 0
neuron differentiation -0.024 0.12 -9999 0 -0.47 5 5
neuron adhesion -0.024 0.15 -9999 0 -0.49 9 9
LRP8 0 0.088 -9999 0 -0.62 4 4
GSK3B -0.021 0.11 -9999 0 -0.45 3 3
RELN/VLDLR/DAB1/Fyn -0.057 0.16 -9999 0 -0.39 25 25
MAP3K11 0.013 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/P13K -0.04 0.12 -9999 0 -0.3 28 28
CDK5 0.013 0 -9999 0 -10000 0 0
MAPT -0.059 0.18 -9999 0 -0.51 28 28
neuron migration -0.021 0.15 -9999 0 -0.54 6 6
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.024 0.12 -9999 0 -0.48 5 5
RELN/VLDLR -0.043 0.16 -9999 0 -0.4 24 24
IL1-mediated signaling events

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.014 0.005 -9999 0 -10000 0 0
PRKCZ 0.013 0 -9999 0 -10000 0 0
MAP3K7IP2 0 0 -9999 0 -10000 0 0
ERC1 0.01 0.044 -9999 0 -0.62 1 1
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.049 0.11 -9999 0 -0.5 6 6
IRAK/TOLLIP 0.028 0.004 -9999 0 -10000 0 0
IKBKB 0.013 0 -9999 0 -10000 0 0
IKBKG 0.013 0 -9999 0 -10000 0 0
IL1 alpha/IL1R2 -0.17 0.25 -9999 0 -0.46 80 80
IL1A -0.18 0.28 -9999 0 -0.58 67 67
IL1B -0.059 0.18 -9999 0 -0.45 35 35
IRAK/TRAF6/p62/Atypical PKCs -0.002 0.025 -9999 0 -10000 0 0
IL1R2 -0.056 0.18 -9999 0 -0.55 25 25
IL1R1 -0.006 0.11 -9999 0 -0.62 6 6
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.007 0.11 -9999 0 -0.55 4 4
TOLLIP 0.013 0 -9999 0 -10000 0 0
TICAM2 0.013 0.001 -9999 0 -10000 0 0
MAP3K3 0.013 0 -9999 0 -10000 0 0
TAK1/TAB1/TAB2 0.009 0 -9999 0 -10000 0 0
IKK complex/ELKS 0.059 0.03 -9999 0 -10000 0 0
JUN 0.007 0.1 -9999 0 -0.53 2 2
MAP3K7 0.013 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.059 0.18 -9999 0 -0.7 7 7
IL1 alpha/IL1R1/IL1RAP/MYD88 -0.11 0.21 -9999 0 -0.42 42 42
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 -0.1 0.2 -9999 0 -0.74 7 7
IL1 beta fragment/IL1R1/IL1RAP -0.066 0.18 -9999 0 -0.42 30 30
NFKB1 0.01 0.038 -9999 0 -0.54 1 1
MAPK8 0.001 0.1 -9999 0 -0.54 1 1
IRAK1 0.022 0.004 -9999 0 -10000 0 0
IL1RN/IL1R1 -0.055 0.17 -9999 0 -0.44 33 33
IRAK4 0.013 0 -9999 0 -10000 0 0
PRKCI 0.01 0.038 -9999 0 -0.54 1 1
TRAF6 0.013 0 -9999 0 -10000 0 0
PI3K 0 0.089 -9999 0 -0.42 9 9
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.027 0.14 -9999 0 -0.56 6 6
CHUK 0.013 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.066 0.18 -9999 0 -0.42 30 30
IL1 beta/IL1R2 -0.086 0.19 -9999 0 -0.38 56 56
IRAK/TRAF6/TAK1/TAB1/TAB2 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA -0.081 0.15 -9999 0 -0.64 7 7
IRAK3 -0.015 0.13 -9999 0 -0.62 9 9
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.046 0.17 -9999 0 -0.67 6 6
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.075 0.18 -9999 0 -0.8 7 7
IL1 alpha/IL1R1/IL1RAP -0.13 0.22 -9999 0 -0.39 78 78
RELA 0.013 0 -9999 0 -10000 0 0
MAP3K7IP1 0 0 -9999 0 -10000 0 0
SQSTM1 0.01 0.044 -9999 0 -0.62 1 1
MYD88 0.013 0 -9999 0 -10000 0 0
IRAK/TRAF6/MEKK3 0.035 0.003 -9999 0 -10000 0 0
IL1RAP -0.03 0.16 -9999 0 -0.61 14 14
UBE2N 0.013 0 -9999 0 -10000 0 0
IRAK/TRAF6 -0.063 0.12 -9999 0 -0.55 6 6
CASP1 -0.024 0.15 -9999 0 -0.62 12 12
IL1RN/IL1R2 -0.09 0.2 -9999 0 -0.45 48 48
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.054 0.18 -9999 0 -0.7 6 6
TMEM189-UBE2V1 0.007 0.006 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.048 0.15 -9999 0 -0.53 11 11
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
IL1RN -0.069 0.21 -9999 0 -0.61 27 27
TRAF6/TAK1/TAB1/TAB2 0 0 -9999 0 -10000 0 0
MAP2K6 0.009 0.082 -9999 0 -10000 0 0
Calcium signaling in the CD4+ TCR pathway

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.004 0.056 -9999 0 -0.43 2 2
NFATC2 -0.042 0.13 -9999 0 -0.4 21 21
NFATC3 0 0.036 -9999 0 -10000 0 0
CD40LG -0.19 0.34 -9999 0 -0.86 29 29
PTGS2 -0.21 0.35 -9999 0 -0.81 33 33
JUNB 0.013 0 -9999 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.011 0.015 -9999 0 -10000 0 0
CaM/Ca2+ -0.011 0.015 -9999 0 -10000 0 0
CALM1 0.007 0.011 -9999 0 -10000 0 0
JUN 0.004 0.045 -9999 0 -0.61 1 1
mol:Ca2+ -0.01 0.014 -9999 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0 0.004 -9999 0 -10000 0 0
FOSL1 -0.044 0.18 -9999 0 -0.6 19 19
CREM 0.013 0.001 -9999 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT -0.12 0.15 -9999 0 -0.49 13 13
FOS -0.047 0.17 -9999 0 -0.57 19 19
IFNG -0.22 0.37 -9999 0 -0.82 42 42
AP-1/NFAT1-c-4 -0.21 0.38 -9999 0 -0.89 32 32
FASLG -0.19 0.35 -9999 0 -0.86 31 31
NFAT1-c-4/ICER1 -0.062 0.13 -9999 0 -0.43 11 11
IL2RA -0.18 0.33 -9999 0 -0.85 27 27
FKBP12/FK506 0.009 0 -9999 0 -10000 0 0
CSF2 -0.2 0.34 -9999 0 -0.76 38 38
JunB/Fra1/NFAT1-c-4 -0.097 0.13 -9999 0 -0.41 19 19
IL4 -0.17 0.3 -9999 0 -0.79 22 22
IL2 -0.01 0.053 -9999 0 -0.43 3 3
IL3 -0.02 0.023 -9999 0 -10000 0 0
FKBP1A 0.013 0 -9999 0 -10000 0 0
BATF3 0.007 0.058 -9999 0 -0.58 2 2
mol:FK506 0 0 -9999 0 -10000 0 0
POU2F1 0.013 0.002 -9999 0 -10000 0 0
TCGA08_retinoblastoma

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B -0.002 0.092 -10000 0 -0.58 5 5
CDKN2C -0.006 0.11 -10000 0 -0.58 7 7
CDKN2A -0.01 0.12 -10000 0 -0.58 8 8
CCND2 0.009 0.081 0.27 12 -0.15 5 17
RB1 0 0.089 0.16 1 -0.3 12 13
CDK4 0.017 0.09 0.32 12 -10000 0 12
CDK6 0.01 0.094 0.32 11 -0.18 6 17
G1/S progression 0 0.089 0.3 12 -0.16 1 13
S1P5 pathway

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration 0.079 0.14 0.45 15 -10000 0 15
GNAI2 0.013 0 -10000 0 -10000 0 0
S1P/S1P5/G12 -0.056 0.16 -10000 0 -0.39 37 37
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 -0.016 0.13 -10000 0 -0.57 10 10
RhoA/GTP -0.055 0.15 -10000 0 -0.46 15 15
negative regulation of cAMP metabolic process -0.067 0.17 -10000 0 -0.5 15 15
GNAZ -0.055 0.19 -10000 0 -0.59 23 23
GNAI3 0.013 0 -10000 0 -10000 0 0
GNA12 0.013 0 -10000 0 -10000 0 0
S1PR5 -0.1 0.24 -10000 0 -0.62 37 37
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi -0.067 0.17 -10000 0 -0.51 15 15
RhoA/GDP 0.009 0 -10000 0 -10000 0 0
RHOA 0.013 0 -10000 0 -10000 0 0
GNAI1 -0.021 0.14 -10000 0 -0.62 11 11
Nongenotropic Androgen signaling

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.011 0 -10000 0 -10000 0 0
GNB1/GNG2 -0.039 0.13 -10000 0 -0.31 39 39
regulation of S phase of mitotic cell cycle -0.021 0.1 -10000 0 -0.3 15 15
GNAO1 -0.016 0.13 -10000 0 -0.57 10 10
HRAS 0.013 0.001 -10000 0 -10000 0 0
SHBG/T-DHT 0.008 0.002 -10000 0 -10000 0 0
PELP1 0.013 0.001 -10000 0 -10000 0 0
AKT1 0.011 0 -10000 0 -10000 0 0
MAP2K1 -0.014 0.11 -10000 0 -10000 0 0
T-DHT/AR -0.07 0.16 -10000 0 -0.41 38 38
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP 0 0.002 -10000 0 -0.006 19 19
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 -0.021 0.14 -10000 0 -0.62 11 11
mol:GDP -0.063 0.14 -10000 0 -0.32 38 38
cell proliferation -0.014 0.12 -10000 0 -0.35 7 7
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
FOS -0.025 0.18 -10000 0 -0.51 19 19
mol:Ca2+ -0.016 0.026 -10000 0 -0.071 28 28
MAPK3 -0.013 0.11 -10000 0 -10000 0 0
MAPK1 -0.002 0.063 -10000 0 -10000 0 0
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
mol:IP3 0 0.001 -10000 0 -0.004 19 19
cAMP biosynthetic process 0.016 0.025 -10000 0 -10000 0 0
GNG2 0.01 0.038 -10000 0 -0.54 1 1
potassium channel inhibitor activity 0 0.001 -10000 0 -0.004 19 19
HRAS/GTP -0.051 0.1 -10000 0 -0.3 11 11
actin cytoskeleton reorganization -0.012 0.056 -10000 0 -0.27 9 9
SRC 0.013 0.001 -10000 0 -10000 0 0
voltage-gated calcium channel activity 0 0.001 -10000 0 -0.004 19 19
PI3K 0.001 0.076 -10000 0 -0.36 9 9
apoptosis 0.008 0.11 0.38 7 -10000 0 7
T-DHT/AR/PELP1 -0.052 0.14 -10000 0 -0.34 38 38
HRAS/GDP -0.057 0.13 -10000 0 -0.48 12 12
CREB1 -0.01 0.11 -10000 0 -0.4 7 7
RAC1-CDC42/GTP -0.012 0.057 -10000 0 -0.28 9 9
AR -0.095 0.22 -10000 0 -0.56 38 38
GNB1 0.013 0 -10000 0 -10000 0 0
RAF1 -0.021 0.11 -10000 0 -0.28 11 11
RAC1-CDC42/GDP -0.053 0.12 -10000 0 -0.46 12 12
T-DHT/AR/PELP1/Src -0.038 0.13 -10000 0 -0.31 38 38
MAP2K2 -0.014 0.11 -10000 0 -10000 0 0
T-DHT/AR/PELP1/Src/PI3K -0.021 0.1 -10000 0 -0.3 15 15
GNAZ -0.055 0.19 -10000 0 -0.59 23 23
SHBG 0.012 0.003 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.018 0.11 -10000 0 -0.41 6 6
mol:T-DHT 0 0.001 -10000 0 -0.002 17 17
RAC1 0.013 0 -10000 0 -10000 0 0
GNRH1 0.006 0.047 -10000 0 -0.46 2 2
Gi family/GTP -0.044 0.12 -10000 0 -0.34 14 14
CDC42 0.013 0 -10000 0 -10000 0 0
EGFR-dependent Endothelin signaling events

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.013 0 -9999 0 -10000 0 0
EGFR -0.033 0.16 -9999 0 -0.62 15 15
EGF/EGFR -0.092 0.15 -9999 0 -0.35 36 36
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.039 0.14 -9999 0 -0.46 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA -0.02 0.14 -9999 0 -0.6 11 11
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF -0.081 0.21 -9999 0 -0.57 33 33
EGF/EGFR dimer/SHC -0.063 0.16 -9999 0 -0.36 47 47
mol:GDP -0.067 0.12 -9999 0 -0.58 1 1
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 -0.007 0.1 -9999 0 -0.56 7 7
GRB2/SOS1 0.019 0 -9999 0 -10000 0 0
HRAS/GTP -0.061 0.11 -9999 0 -0.54 1 1
SHC1 0.013 0 -9999 0 -10000 0 0
HRAS/GDP -0.062 0.12 -9999 0 -0.55 1 1
FRAP1 -0.038 0.13 -9999 0 -0.44 2 2
EGF/EGFR dimer -0.084 0.19 -9999 0 -0.43 47 47
SOS1 0.013 0 -9999 0 -10000 0 0
GRB2 0.013 0 -9999 0 -10000 0 0
ETA receptor/Endothelin-1 -0.02 0.12 -9999 0 -0.42 18 18
Visual signal transduction: Rods

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.013 0 -9999 0 -10000 0 0
GNAT1/GTP 0.002 0.039 -9999 0 -0.39 2 2
Metarhodopsin II/Arrestin 0.003 0.024 -9999 0 -0.33 1 1
PDE6G/GNAT1/GTP -0.014 0.1 -9999 0 -0.37 15 15
mol:GTP 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
GNAT1 0.003 0.054 -9999 0 -0.54 2 2
GRK1 0.003 0.005 -9999 0 -10000 0 0
CNG Channel -0.18 0.2 -9999 0 -0.59 25 25
mol:Na + -0.14 0.17 -9999 0 -0.53 17 17
mol:ADP 0.003 0.005 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.02 0.13 -9999 0 -0.35 25 25
mol:GDP 0 0 -9999 0 -10000 0 0
cGMP/CNG Channel -0.15 0.17 -9999 0 -0.55 17 17
CNGB1 -0.17 0.27 -9999 0 -0.58 63 63
RDH5 -0.02 0.13 -9999 0 -0.55 12 12
SAG -0.001 0.038 -9999 0 -0.54 1 1
mol:Ca2+ -0.12 0.18 -9999 0 -0.51 17 17
Na + (4 Units) -0.13 0.16 -9999 0 -0.49 17 17
RGS9 -0.029 0.15 -9999 0 -0.56 15 15
GNB1/GNGT1 -0.011 0.11 -9999 0 -0.44 12 12
GNAT1/GDP -0.015 0.12 -9999 0 -0.39 8 8
GUCY2D -0.034 0.16 -9999 0 -0.56 16 16
GNGT1 -0.027 0.14 -9999 0 -0.61 12 12
GUCY2F 0.001 0.004 -9999 0 -10000 0 0
GNB5 0.013 0 -9999 0 -10000 0 0
mol:GMP (4 units) -0.063 0.16 -9999 0 -0.35 36 36
mol:11-cis-retinal -0.02 0.13 -9999 0 -0.55 12 12
mol:cGMP -0.024 0.11 -9999 0 -0.34 3 3
GNB1 0.013 0 -9999 0 -10000 0 0
Rhodopsin -0.011 0.097 -9999 0 -0.4 12 12
SLC24A1 0.013 0 -9999 0 -10000 0 0
CNGA1 -0.044 0.17 -9999 0 -0.57 20 20
Metarhodopsin II 0.005 0.005 -9999 0 -10000 0 0
mol:Ca ++ 0 0 -9999 0 -10000 0 0
GC1/GCAP Family -0.027 0.12 -9999 0 -0.35 9 9
RGS9BP -0.019 0.13 -9999 0 -0.58 11 11
Metarhodopsin II/Transducin -0.002 0.073 -9999 0 -0.3 10 10
GCAP Family/Ca ++ -0.008 0.085 -9999 0 -0.31 15 15
PDE6A/B -0.073 0.18 -9999 0 -0.42 42 42
mol:Pi -0.02 0.13 -9999 0 -0.35 25 25
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
Transducin -0.005 0.095 -9999 0 -0.36 13 13
PDE6B -0.059 0.2 -9999 0 -0.6 24 24
PDE6A -0.041 0.16 -9999 0 -0.55 19 19
PDE6G -0.026 0.15 -9999 0 -0.6 13 13
RHO 0.005 0.006 -9999 0 -10000 0 0
PDE6 -0.11 0.17 -9999 0 -0.65 8 8
GUCA1A -0.015 0.11 -9999 0 -0.54 9 9
GC2/GCAP Family -0.007 0.085 -9999 0 -0.36 4 4
GUCA1C 0 0.038 -9999 0 -0.54 1 1
GUCA1B -0.002 0.095 -9999 0 -0.61 5 5
Signaling events mediated by PTP1B

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.093 -10000 0 -0.59 5 5
Jak2/Leptin Receptor -0.077 0.12 -10000 0 -0.49 5 5
PTP1B/AKT1 -0.01 0.075 0.18 1 -0.34 3 4
FYN -0.001 0.088 -10000 0 -0.56 5 5
p210 bcr-abl/PTP1B -0.017 0.082 0.19 2 -0.31 7 9
EGFR -0.035 0.16 -10000 0 -0.62 15 15
EGF/EGFR -0.083 0.14 -10000 0 -0.37 28 28
CSF1 -0.003 0.098 -10000 0 -0.62 5 5
AKT1 0.012 0.002 -10000 0 -10000 0 0
INSR 0.012 0.002 -10000 0 -10000 0 0
PTP1B/N-cadherin -0.08 0.16 0.18 1 -0.36 43 44
Insulin Receptor/Insulin -0.028 0.069 -10000 0 -0.42 3 3
HCK -0.015 0.13 -10000 0 -0.62 9 9
CRK 0.013 0 -10000 0 -10000 0 0
TYK2 -0.009 0.078 -10000 0 -0.5 1 1
EGF -0.082 0.21 -10000 0 -0.57 33 33
YES1 0.013 0 -10000 0 -10000 0 0
CAV1 -0.026 0.1 0.19 2 -0.4 5 7
TXN 0.011 0.005 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 -0.016 0.098 -10000 0 -0.38 7 7
cell migration 0.017 0.082 0.31 7 -0.19 2 9
STAT3 0.012 0.001 -10000 0 -10000 0 0
PRLR -0.18 0.28 -10000 0 -0.6 66 66
ITGA2B -0.05 0.18 -10000 0 -0.6 21 21
CSF1R -0.03 0.16 -10000 0 -0.62 14 14
Prolactin Receptor/Prolactin -0.15 0.22 -10000 0 -0.45 67 67
FGR 0.004 0.07 -10000 0 -0.57 3 3
PTP1B/p130 Cas -0.01 0.078 -10000 0 -0.34 3 3
Crk/p130 Cas -0.004 0.073 -10000 0 -0.48 1 1
DOK1 -0.008 0.092 0.19 1 -0.49 3 4
JAK2 -0.071 0.13 -10000 0 -0.42 7 7
Jak2/Leptin Receptor/Leptin -0.066 0.11 -10000 0 -0.54 5 5
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
PTPN1 -0.017 0.083 0.19 2 -0.31 7 9
LYN 0.01 0.044 -10000 0 -0.62 1 1
CDH2 -0.12 0.25 -10000 0 -0.57 48 48
SRC 0.009 0.033 -10000 0 -10000 0 0
ITGB3 -0.085 0.22 -10000 0 -0.57 34 34
CAT1/PTP1B -0.066 0.14 -10000 0 -0.42 13 13
CAPN1 0.013 0.003 -10000 0 -10000 0 0
CSK 0.013 0 -10000 0 -10000 0 0
PI3K -0.031 0.08 -10000 0 -0.55 1 1
mol:H2O2 -0.001 0.004 -10000 0 -10000 0 0
STAT3 (dimer) -0.059 0.11 -10000 0 -0.64 3 3
negative regulation of transcription -0.071 0.13 -10000 0 -0.41 7 7
FCGR2A 0 0.088 -10000 0 -0.62 4 4
FER 0.001 0.077 -10000 0 -0.63 3 3
alphaIIb/beta3 Integrin -0.1 0.2 -10000 0 -0.44 52 52
BLK -0.077 0.21 -10000 0 -0.57 31 31
Insulin Receptor/Insulin/Shc 0.008 0.06 -10000 0 -0.37 5 5
RHOA 0.013 0.003 -10000 0 -10000 0 0
LEPR 0.007 0.058 -10000 0 -0.58 2 2
BCAR1 0.013 0 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.013 0 -10000 0 -10000 0 0
mol:NADPH -0.001 0.003 -10000 0 -10000 0 0
TRPV6 -0.066 0.15 -10000 0 -0.43 15 15
PRL -0.005 0.066 -10000 0 -0.54 3 3
SOCS3 0.007 0.14 -10000 0 -1.3 2 2
SPRY2 -0.009 0.11 -10000 0 -0.6 7 7
Insulin Receptor/Insulin/IRS1 -0.008 0.097 -10000 0 -0.38 13 13
CSF1/CSF1R -0.034 0.13 -10000 0 -0.37 19 19
Ras protein signal transduction 0.019 0.025 -10000 0 -10000 0 0
IRS1 -0.012 0.12 -10000 0 -0.61 8 8
INS -0.014 0.094 -10000 0 -0.61 5 5
LEP -0.078 0.2 -10000 0 -0.54 32 32
STAT5B -0.036 0.081 -10000 0 -0.32 4 4
STAT5A -0.039 0.086 -10000 0 -0.32 6 6
GRB2 0.013 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.017 0.1 -10000 0 -0.39 9 9
CSN2 -0.05 0.097 -10000 0 -0.56 1 1
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
LAT -0.012 0.11 -10000 0 -0.53 8 8
YBX1 0.02 0.002 -10000 0 -10000 0 0
LCK -0.005 0.1 -10000 0 -0.6 6 6
SHC1 0.013 0 -10000 0 -10000 0 0
NOX4 -0.018 0.13 -10000 0 -0.59 10 10
Syndecan-3-mediated signaling events

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.013 0 -9999 0 -10000 0 0
Syndecan-3/Src/Cortactin -0.088 0.13 -9999 0 -0.86 1 1
Syndecan-3/Neurocan -0.015 0.068 -9999 0 -0.3 10 10
POMC -0.11 0.23 -9999 0 -0.56 44 44
EGFR -0.033 0.16 -9999 0 -0.62 15 15
Syndecan-3/EGFR -0.026 0.093 -9999 0 -0.34 15 15
AGRP -0.004 0.076 -9999 0 -0.54 4 4
NCSTN 0.01 0.044 -9999 0 -0.62 1 1
PSENEN 0.013 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.013 0 -9999 0 -10000 0 0
APH1A 0.013 0 -9999 0 -10000 0 0
NCAN -0.014 0.11 -9999 0 -0.54 9 9
long-term memory -0.009 0.055 -9999 0 -0.43 2 2
Syndecan-3/IL8 -0.06 0.12 -9999 0 -0.34 21 21
PSEN1 0.01 0.044 -9999 0 -0.62 1 1
Src/Cortactin 0.019 0 -9999 0 -10000 0 0
FYN -0.001 0.088 -9999 0 -0.56 5 5
limb bud formation -0.004 0.045 -9999 0 -0.64 1 1
MC4R 0.001 0.038 -9999 0 -0.54 1 1
SRC 0.013 0 -9999 0 -10000 0 0
PTN -0.18 0.28 -9999 0 -0.57 69 69
FGFR/FGF/Syndecan-3 -0.004 0.045 -9999 0 -0.64 1 1
neuron projection morphogenesis -0.072 0.15 -9999 0 -0.64 2 2
Syndecan-3/AgRP -0.009 0.056 -9999 0 -0.62 1 1
Syndecan-3/AgRP/MC4R -0.005 0.059 -9999 0 -0.6 1 1
Fyn/Cortactin 0.009 0.064 -9999 0 -0.4 5 5
SDC3 -0.004 0.046 -9999 0 -0.65 1 1
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.059 0.12 -9999 0 -0.33 21 21
IL8 -0.1 0.24 -9999 0 -0.58 40 40
Syndecan-3/Fyn/Cortactin 0.021 0.062 -9999 0 -0.44 2 2
Syndecan-3/CASK -0.004 0.043 -9999 0 -0.62 1 1
alpha-MSH/MC4R -0.079 0.17 -9999 0 -0.4 45 45
Gamma Secretase 0.034 0.035 -9999 0 -10000 0 0
Regulation of Androgen receptor activity

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.021 0.002 -9999 0 -10000 0 0
SMARCC1 0.009 0.011 -9999 0 -10000 0 0
REL -0.002 0.095 -9999 0 -0.6 5 5
HDAC7 -0.051 0.15 -9999 0 -0.47 6 6
JUN 0.009 0.044 -9999 0 -0.62 1 1
EP300 0.009 0.044 -9999 0 -0.62 1 1
KAT2B 0.009 0.044 -9999 0 -0.62 1 1
KAT5 0.013 0 -9999 0 -10000 0 0
MAPK14 -0.019 0.12 -9999 0 -0.44 15 15
FOXO1 0.009 0.044 -9999 0 -0.62 1 1
T-DHT/AR -0.057 0.16 -9999 0 -0.47 9 9
MAP2K6 -0.035 0.16 -9999 0 -0.6 15 15
BRM/BAF57 0.013 0.045 -9999 0 -0.44 2 2
MAP2K4 0.006 0.044 -9999 0 -0.62 1 1
SMARCA2 0.006 0.059 -9999 0 -0.59 2 2
PDE9A -0.19 0.4 -9999 0 -1.1 29 29
NCOA2 -0.059 0.2 -9999 0 -0.62 23 23
CEBPA -0.03 0.16 -9999 0 -0.62 14 14
EHMT2 0.012 0.004 -9999 0 -10000 0 0
cell proliferation -0.057 0.18 -9999 0 -0.51 11 11
NR0B1 -0.038 0.15 -9999 0 -0.54 17 17
EGR1 -0.014 0.12 -9999 0 -0.57 9 9
RXRs/9cRA 0.002 0.076 -9999 0 -0.3 12 12
AR/RACK1/Src -0.044 0.13 -9999 0 -0.41 13 13
AR/GR -0.042 0.13 -9999 0 -0.4 13 13
GNB2L1 0.012 0.001 -9999 0 -10000 0 0
PKN1 -0.005 0.1 -9999 0 -0.6 6 6
RCHY1 0.013 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity 0 0.002 -9999 0 -10000 0 0
MAPK8 -0.009 0.1 -9999 0 -0.46 10 10
T-DHT/AR/TIF2/CARM1 -0.069 0.19 -9999 0 -0.6 15 15
SRC -0.021 0.12 -9999 0 -0.39 8 8
NR3C1 0 0.088 -9999 0 -0.62 4 4
KLK3 -0.14 0.17 -9999 0 -0.53 12 12
APPBP2 0.01 0.007 -9999 0 -10000 0 0
TRIM24 0 0.088 -9999 0 -0.62 4 4
T-DHT/AR/TIP60 -0.039 0.13 -9999 0 -0.41 13 13
TMPRSS2 -0.22 0.42 -9999 0 -1.1 35 35
RXRG -0.018 0.12 -9999 0 -0.54 10 10
mol:9cRA 0 0.001 -9999 0 -10000 0 0
RXRA 0.006 0.062 -9999 0 -0.62 2 2
RXRB 0.012 0.001 -9999 0 -10000 0 0
CARM1 0.012 0.002 -9999 0 -10000 0 0
NR2C2 -0.015 0.13 -9999 0 -0.62 9 9
KLK2 -0.069 0.19 -9999 0 -0.56 16 16
AR -0.045 0.12 -9999 0 -0.36 16 16
SENP1 0.012 0.001 -9999 0 -10000 0 0
HSP90AA1 0.013 0 -9999 0 -10000 0 0
MDM2 0.011 0.043 -9999 0 -0.6 1 1
SRY 0.001 0.006 -9999 0 -10000 0 0
GATA2 -0.02 0.14 -9999 0 -0.61 11 11
MYST2 0.013 0.001 -9999 0 -10000 0 0
HOXB13 -0.19 0.28 -9999 0 -0.59 67 67
T-DHT/AR/RACK1/Src -0.033 0.13 -9999 0 -0.4 13 13
positive regulation of transcription -0.02 0.14 -9999 0 -0.61 11 11
DNAJA1 0.01 0.007 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.027 0.025 -9999 0 -0.33 1 1
NCOA1 0.017 0.005 -9999 0 -10000 0 0
SPDEF -0.28 0.3 -9999 0 -0.58 103 103
T-DHT/AR/TIF2 -0.039 0.18 -9999 0 -0.58 13 13
T-DHT/AR/Hsp90 -0.039 0.13 -9999 0 -0.42 12 12
GSK3B 0.011 0.004 -9999 0 -10000 0 0
NR2C1 0.013 0.001 -9999 0 -10000 0 0
mol:T-DHT -0.029 0.13 -9999 0 -0.36 23 23
SIRT1 0.006 0.062 -9999 0 -0.62 2 2
ZMIZ2 0.014 0.006 -9999 0 -10000 0 0
POU2F1 0.002 0.047 -9999 0 -10000 0 0
T-DHT/AR/DAX-1 -0.072 0.15 -9999 0 -0.44 17 17
CREBBP 0.013 0 -9999 0 -10000 0 0
SMARCE1 0.012 0.003 -9999 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.013 0 -9999 0 -10000 0 0
SPHK1 0.001 0.082 -9999 0 -0.58 4 4
GNAI2 0.013 0 -9999 0 -10000 0 0
mol:S1P 0.014 0.044 -9999 0 -0.3 2 2
GNAO1 -0.016 0.13 -9999 0 -0.57 10 10
mol:Sphinganine-1-P 0.013 0.061 -9999 0 -0.42 4 4
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.032 0.032 -9999 0 -10000 0 0
GNAI3 0.013 0 -9999 0 -10000 0 0
G12/G13 0.019 0 -9999 0 -10000 0 0
S1PR3 -0.023 0.14 -9999 0 -0.6 12 12
S1PR2 0.013 0 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
S1P1/S1P -0.006 0.034 -9999 0 -0.26 2 2
S1PR5 -0.1 0.24 -9999 0 -0.62 37 37
S1PR4 -0.016 0.13 -9999 0 -0.57 10 10
GNAI1 -0.021 0.14 -9999 0 -0.62 11 11
S1P/S1P5/G12 -0.041 0.15 -9999 0 -0.35 37 37
S1P/S1P3/Gq -0.039 0.14 -9999 0 -0.47 11 11
S1P/S1P4/Gi -0.021 0.13 -9999 0 -0.43 8 8
GNAQ 0.01 0.044 -9999 0 -0.62 1 1
GNAZ -0.055 0.19 -9999 0 -0.59 23 23
GNA14 -0.063 0.2 -9999 0 -0.56 27 27
GNA15 -0.039 0.17 -9999 0 -0.62 17 17
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
GNA11 -0.009 0.12 -9999 0 -0.62 7 7
ABCC1 0.005 0.066 -9999 0 -0.54 3 3
Visual signal transduction: Cones

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin -0.01 0.1 -9999 0 -0.34 18 18
RGS9BP -0.019 0.13 -9999 0 -0.58 11 11
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0.003 0.005 -9999 0 -10000 0 0
mol:Na + -0.042 0.13 -9999 0 -0.37 28 28
mol:ADP 0.006 0.051 -9999 0 -0.41 3 3
GNAT2 0.01 0.005 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.02 0.13 -9999 0 -0.35 25 25
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP 0.008 0.005 -9999 0 -10000 0 0
GRK7 0.003 0.07 -9999 0 -0.57 3 3
CNGB3 -0.064 0.2 -9999 0 -0.6 24 24
Cone Metarhodopsin II/X-Arrestin 0.002 0.004 -9999 0 -10000 0 0
mol:Ca2+ -0.038 0.12 -9999 0 -0.33 30 30
Cone PDE6 -0.014 0.11 -9999 0 -0.66 1 1
Cone Metarhodopsin II 0.004 0.04 -9999 0 -0.32 3 3
Na + (4 Units) -0.037 0.12 -9999 0 -0.33 30 30
GNAT2/GDP -0.011 0.11 -9999 0 -0.32 13 13
GNB5 0.013 0 -9999 0 -10000 0 0
mol:GMP (4 units) 0.009 0.005 -9999 0 -10000 0 0
Cone Transducin -0.01 0.11 -9999 0 -0.36 18 18
SLC24A2 0 0.054 -9999 0 -0.54 2 2
GNB3/GNGT2 -0.023 0.14 -9999 0 -0.46 18 18
GNB3 -0.014 0.12 -9999 0 -0.6 9 9
GNAT2/GTP 0.007 0.004 -9999 0 -10000 0 0
CNGA3 -0.003 0.076 -9999 0 -0.54 4 4
ARR3 0.003 0.005 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel -0.042 0.13 -9999 0 -0.37 28 28
mol:Pi -0.02 0.13 -9999 0 -0.35 25 25
Cone CNG Channel -0.041 0.1 -9999 0 -0.32 19 19
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + 0 0.054 -9999 0 -0.54 2 2
RGS9 -0.029 0.15 -9999 0 -0.56 15 15
PDE6C 0.003 0.005 -9999 0 -10000 0 0
GNGT2 -0.017 0.13 -9999 0 -0.61 10 10
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H 0.002 0.005 -9999 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 -0.019 0.18 -9999 0 -0.56 17 17
MAP4K1 -0.017 0.13 -9999 0 -0.61 10 10
MAP3K8 0.006 0.062 -9999 0 -0.62 2 2
PRKCB -0.029 0.15 -9999 0 -0.6 14 14
DBNL 0.013 0 -9999 0 -10000 0 0
CRKL 0.013 0 -9999 0 -10000 0 0
MAP3K1 0.005 0.14 -9999 0 -0.58 8 8
JUN -0.031 0.2 -9999 0 -0.62 19 19
MAP3K7 0.007 0.14 -9999 0 -0.58 8 8
GRAP2 -0.023 0.14 -9999 0 -0.6 12 12
CRK 0.013 0 -9999 0 -10000 0 0
MAP2K4 0.011 0.14 -9999 0 -0.56 9 9
LAT -0.002 0.095 -9999 0 -0.61 5 5
LCP2 0.001 0.085 -9999 0 -0.6 4 4
MAPK8 -0.039 0.2 -9999 0 -0.64 19 19
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family -0.001 0.14 -9999 0 -0.62 8 8
LAT/GRAP2/SLP76/HPK1/HIP-55 -0.012 0.17 -9999 0 -0.76 8 8
Cellular roles of Anthrax toxin

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.004 0.073 -10000 0 -0.6 3 3
ANTXR2 -0.014 0.13 -10000 0 -0.6 9 9
negative regulation of myeloid dendritic cell antigen processing and presentation -0.004 0.018 -10000 0 -0.077 12 12
monocyte activation -0.044 0.14 -10000 0 -0.44 20 20
MAP2K2 -0.002 0.007 -10000 0 -10000 0 0
MAP2K1 -0.004 0.015 -10000 0 -10000 0 0
MAP2K7 -0.004 0.015 -10000 0 -10000 0 0
MAP2K6 -0.027 0.087 -10000 0 -0.33 15 15
CYAA -0.005 0.079 -10000 0 -0.32 12 12
MAP2K4 -0.005 0.028 -10000 0 -0.34 1 1
IL1B -0.043 0.12 -10000 0 -0.32 29 29
Channel -0.005 0.084 -10000 0 -0.34 12 12
NLRP1 -0.025 0.085 -10000 0 -0.35 13 13
CALM1 0.013 0 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.005 0.021 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.004 0.018 0.077 12 -10000 0 12
MAPK3 -0.004 0.015 -10000 0 -10000 0 0
MAPK1 -0.004 0.015 -10000 0 -10000 0 0
PGR -0.078 0.14 -10000 0 -0.32 49 49
PA/Cellular Receptors -0.006 0.092 -10000 0 -0.38 12 12
apoptosis -0.004 0.018 -10000 0 -0.077 12 12
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) -0.003 0.078 -10000 0 -0.32 12 12
macrophage activation 0.014 0.017 -10000 0 -10000 0 0
TNF -0.041 0.17 -10000 0 -0.57 19 19
VCAM1 -0.044 0.14 -10000 0 -0.44 20 20
platelet activation -0.005 0.021 -10000 0 -10000 0 0
MAPKKK cascade -0.004 0.03 0.14 2 -10000 0 2
IL18 -0.019 0.1 -10000 0 -0.38 12 12
negative regulation of macrophage activation -0.004 0.018 -10000 0 -0.077 12 12
LEF -0.004 0.018 -10000 0 -0.077 12 12
CASP1 -0.021 0.068 -10000 0 -0.24 14 14
mol:cAMP -0.005 0.021 -10000 0 -10000 0 0
necrosis -0.004 0.018 -10000 0 -0.077 12 12
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) -0.004 0.079 -10000 0 -0.32 12 12
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Hedgehog signaling events mediated by Gli proteins

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.013 0.001 -9999 0 -10000 0 0
HDAC2 0.013 0.001 -9999 0 -10000 0 0
GNB1/GNG2 -0.028 0.13 -9999 0 -0.38 24 24
forebrain development -0.098 0.19 -9999 0 -0.49 25 25
GNAO1 -0.018 0.13 -9999 0 -0.57 10 10
SMO/beta Arrestin2 -0.038 0.15 -9999 0 -0.45 23 23
SMO -0.06 0.2 -9999 0 -0.62 23 23
ARRB2 0.01 0.006 -9999 0 -10000 0 0
GLI3/SPOP 0.031 0.1 -9999 0 -0.31 1 1
mol:GTP -0.001 0.003 -9999 0 -10000 0 0
GSK3B 0.013 0 -9999 0 -10000 0 0
GNAI2 0.011 0.005 -9999 0 -10000 0 0
SIN3/HDAC complex 0.034 0.004 -9999 0 -10000 0 0
GNAI1 -0.023 0.14 -9999 0 -0.62 11 11
XPO1 0.01 0.007 -9999 0 -10000 0 0
GLI1/Su(fu) -0.12 0.17 -9999 0 -0.57 13 13
SAP30 0.013 0.001 -9999 0 -10000 0 0
mol:GDP -0.06 0.2 -9999 0 -0.62 23 23
MIM/GLI2A -0.096 0.23 -9999 0 -0.63 31 31
IFT88 0.013 0 -9999 0 -10000 0 0
GNAI3 0.011 0.005 -9999 0 -10000 0 0
GLI2 0.016 0.065 -9999 0 -10000 0 0
GLI3 0.026 0.11 -9999 0 -0.33 2 2
CSNK1D 0.013 0 -9999 0 -10000 0 0
CSNK1E 0.013 0 -9999 0 -10000 0 0
SAP18 0.013 0.001 -9999 0 -10000 0 0
embryonic digit morphogenesis 0.013 0 -9999 0 -10000 0 0
GNG2 0.01 0.038 -9999 0 -0.54 1 1
Gi family/GTP -0.058 0.15 -9999 0 -0.35 28 28
SIN3B 0.013 0.001 -9999 0 -10000 0 0
SIN3A 0.013 0.001 -9999 0 -10000 0 0
GLI3/Su(fu) 0.027 0.072 -9999 0 -10000 0 0
GLI2/Su(fu) 0.002 0.08 -9999 0 -10000 0 0
FOXA2 -0.35 0.49 -9999 0 -1.1 60 60
neural tube patterning -0.098 0.19 -9999 0 -0.49 25 25
SPOP 0.013 0 -9999 0 -10000 0 0
Su(fu)/PIAS1 0 0.069 -9999 0 -10000 0 0
GNB1 0.013 0 -9999 0 -10000 0 0
CSNK1G2 0.013 0 -9999 0 -10000 0 0
CSNK1G3 0.013 0 -9999 0 -10000 0 0
MTSS1 -0.096 0.23 -9999 0 -0.63 31 31
embryonic limb morphogenesis -0.098 0.19 -9999 0 -0.49 25 25
SUFU -0.007 0.076 -9999 0 -10000 0 0
LGALS3 0.013 0 -9999 0 -10000 0 0
catabolic process 0.033 0.096 -9999 0 -10000 0 0
GLI3A/CBP -0.026 0.11 -9999 0 -0.35 12 12
KIF3A 0.01 0.044 -9999 0 -0.62 1 1
GLI1 -0.1 0.2 -9999 0 -0.5 25 25
RAB23 0.013 0 -9999 0 -10000 0 0
CSNK1A1 0.013 0 -9999 0 -10000 0 0
IFT172 0.01 0.044 -9999 0 -0.62 1 1
RBBP7 0.01 0.038 -9999 0 -0.54 1 1
Su(fu)/Galectin3 0 0.069 -9999 0 -10000 0 0
GNAZ -0.057 0.19 -9999 0 -0.59 23 23
RBBP4 0.001 0.088 -9999 0 -0.62 4 4
CSNK1G1 0.013 0 -9999 0 -10000 0 0
PIAS1 0.013 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GLI2/SPOP 0.022 0.06 -9999 0 -10000 0 0
STK36 0.01 0.007 -9999 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.042 0.13 -9999 0 -0.46 9 9
PTCH1 -0.098 0.22 -9999 0 -0.75 13 13
MIM/GLI1 -0.2 0.3 -9999 0 -0.59 63 63
CREBBP -0.026 0.11 -9999 0 -0.35 12 12
Su(fu)/SIN3/HDAC complex 0.037 0.04 -9999 0 -10000 0 0
Presenilin action in Notch and Wnt signaling

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) -0.049 0.14 -10000 0 -0.62 9 9
HDAC1 0.014 0.014 -10000 0 -10000 0 0
AES 0.014 0.006 -10000 0 -10000 0 0
FBXW11 0.013 0 -10000 0 -10000 0 0
DTX1 -0.002 0.095 -10000 0 -0.61 5 5
LRP6/FZD1 0.019 0 -10000 0 -10000 0 0
TLE1 0.012 0.005 -10000 0 -10000 0 0
AP1 -0.015 0.11 -10000 0 -0.32 16 16
NCSTN 0.01 0.044 -10000 0 -0.62 1 1
ADAM10 -0.015 0.13 -10000 0 -0.62 9 9
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.016 0.13 -10000 0 -0.39 15 15
NICD/RBPSUH -0.021 0.12 -10000 0 -0.6 9 9
WIF1 -0.11 0.24 -10000 0 -0.57 43 43
NOTCH1 -0.029 0.13 -10000 0 -0.64 9 9
PSENEN 0.013 0 -10000 0 -10000 0 0
KREMEN2 -0.058 0.19 -10000 0 -0.57 25 25
DKK1 -0.16 0.27 -10000 0 -0.58 59 59
beta catenin/beta TrCP1 0.023 0.049 -10000 0 -10000 0 0
APH1B 0.013 0 -10000 0 -10000 0 0
APH1A 0.013 0 -10000 0 -10000 0 0
AXIN1 -0.007 0.044 -10000 0 -10000 0 0
CtBP/CBP/TCF1/TLE1/AES 0.019 0.063 0.23 2 -0.28 1 3
PSEN1 0.01 0.044 -10000 0 -0.62 1 1
FOS -0.041 0.17 -10000 0 -0.57 19 19
JUN 0.01 0.044 -10000 0 -0.62 1 1
MAP3K7 0.013 0.006 -10000 0 -10000 0 0
CTNNB1 0.017 0.052 0.21 4 -10000 0 4
MAPK3 0.013 0 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.057 0.17 -10000 0 -0.44 21 21
HNF1A -0.059 0.18 -10000 0 -0.53 27 27
CTBP1 0.014 0.006 -10000 0 -10000 0 0
MYC -0.12 0.43 -10000 0 -1.4 21 21
NKD1 -0.031 0.16 -10000 0 -0.58 15 15
FZD1 0.013 0 -10000 0 -10000 0 0
NOTCH1 precursor/Deltex homolog 1 -0.029 0.13 -10000 0 -0.6 9 9
apoptosis -0.015 0.11 -10000 0 -0.32 16 16
Delta 1/NOTCHprecursor -0.043 0.14 -10000 0 -0.6 9 9
DLL1 -0.033 0.16 -10000 0 -0.57 16 16
PPARD 0.005 0.1 -10000 0 -1.4 1 1
Gamma Secretase 0.029 0.037 -10000 0 -10000 0 0
APC -0.008 0.045 -10000 0 -10000 0 0
DVL1 -0.001 0.029 -10000 0 -10000 0 0
CSNK2A1 0.012 0.002 -10000 0 -10000 0 0
MAP3K7IP1 0.001 0.006 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 -0.13 0.21 -10000 0 -0.44 42 42
LRP6 0.013 0 -10000 0 -10000 0 0
CSNK1A1 0.012 0.002 -10000 0 -10000 0 0
NLK 0.018 0.015 -10000 0 -10000 0 0
CCND1 -0.05 0.27 -10000 0 -1.1 10 10
WNT1 -0.011 0.11 -10000 0 -0.54 8 8
Axin1/APC/beta catenin 0.02 0.055 -10000 0 -10000 0 0
DKK2 -0.049 0.18 -10000 0 -0.58 21 21
NOTCH1 precursor/DVL1 -0.025 0.11 -10000 0 -0.55 9 9
GSK3B 0.013 0.001 -10000 0 -10000 0 0
FRAT1 0.013 0.003 -10000 0 -10000 0 0
NOTCH/Deltex homolog 1 -0.035 0.13 -10000 0 -0.62 9 9
PPP2R5D 0.014 0.073 0.27 15 -10000 0 15
MAPK1 0.013 0 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 -0.057 0.14 -10000 0 -0.34 17 17
RBPJ 0.013 0 -10000 0 -10000 0 0
CREBBP 0.014 0.006 -10000 0 -10000 0 0
Canonical Wnt signaling pathway

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.018 0.036 -10000 0 -10000 0 0
AES 0.022 0.028 -10000 0 -10000 0 0
FBXW11 0.013 0 -10000 0 -10000 0 0
mol:GTP 0 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.016 0.008 -10000 0 -10000 0 0
SMAD4 0.003 0.076 -10000 0 -0.62 3 3
DKK2 -0.049 0.18 -10000 0 -0.58 21 21
TLE1 0.022 0.029 -10000 0 -10000 0 0
MACF1 0.013 0 -10000 0 -10000 0 0
CTNNB1 0.04 0.084 0.31 2 -10000 0 2
WIF1 -0.11 0.24 -10000 0 -0.57 43 43
beta catenin/RanBP3 0.065 0.16 0.38 39 -10000 0 39
KREMEN2 -0.058 0.19 -10000 0 -0.57 25 25
DKK1 -0.16 0.27 -10000 0 -0.58 59 59
beta catenin/beta TrCP1 0.048 0.079 0.3 2 -10000 0 2
FZD1 0.013 0.001 -10000 0 -10000 0 0
AXIN2 -0.081 0.3 -10000 0 -1.3 11 11
AXIN1 0.013 0.001 -10000 0 -10000 0 0
RAN 0.013 0.001 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.021 0.036 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.039 0.11 -10000 0 -0.53 4 4
Axin1/APC/GSK3 0.023 0.052 0.24 3 -10000 0 3
Axin1/APC/GSK3/beta catenin/Macf1 0.048 0.057 -10000 0 -10000 0 0
HNF1A -0.05 0.18 -10000 0 -0.5 27 27
CTBP1 0.023 0.031 -10000 0 -10000 0 0
MYC -0.15 0.44 -10000 0 -1.4 21 21
RANBP3 0.013 0.001 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.062 0.17 -10000 0 -0.44 21 21
NKD1 -0.031 0.16 -10000 0 -0.58 15 15
TCF4 0.004 0.1 -10000 0 -0.57 6 6
TCF3 0.022 0.031 -10000 0 -10000 0 0
WNT1/LRP6/FZD1/Axin1 0.014 0.061 -10000 0 -10000 0 0
Ran/GTP 0.01 0.003 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.065 0.19 0.43 34 -0.51 2 36
LEF1 -0.007 0.13 -10000 0 -0.56 10 10
DVL1 0.049 0.038 -10000 0 -10000 0 0
CSNK2A1 0.013 0 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.007 0.14 -10000 0 -0.57 5 5
DKK1/LRP6/Kremen 2 -0.12 0.21 -10000 0 -0.44 42 42
LRP6 0.013 0.001 -10000 0 -10000 0 0
CSNK1A1 0.022 0.034 -10000 0 -10000 0 0
NLK 0.011 0.006 -10000 0 -10000 0 0
CCND1 -0.075 0.28 -10000 0 -1.1 11 11
WNT1 -0.01 0.11 -10000 0 -0.54 8 8
GSK3A 0.013 0.001 -10000 0 -10000 0 0
GSK3B 0.013 0.001 -10000 0 -10000 0 0
FRAT1 0.012 0.001 -10000 0 -10000 0 0
PPP2R5D 0.045 0.076 0.3 15 -10000 0 15
APC 0.024 0.06 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.051 0.087 0.23 25 -10000 0 25
CREBBP 0.022 0.031 -10000 0 -10000 0 0
Angiopoietin receptor Tie2-mediated signaling

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.011 0.24 -10000 0 -0.9 11 11
NCK1/PAK1/Dok-R -0.037 0.1 -10000 0 -0.44 11 11
NCK1/Dok-R -0.027 0.28 -10000 0 -1.1 11 11
PIK3CA 0.009 0.044 -10000 0 -0.62 1 1
mol:beta2-estradiol 0.004 0.052 0.23 7 -10000 0 7
RELA 0.013 0 -10000 0 -10000 0 0
SHC1 0.013 0.001 -10000 0 -10000 0 0
Rac/GDP 0.009 0 -10000 0 -10000 0 0
F2 -0.018 0.13 0.25 6 -0.55 10 16
TNIP2 0.013 0 -10000 0 -10000 0 0
NF kappa B/RelA -0.069 0.23 -10000 0 -0.98 11 11
FN1 -0.089 0.22 -10000 0 -0.57 36 36
PLD2 -0.018 0.27 -10000 0 -1.1 11 11
PTPN11 0.013 0 -10000 0 -10000 0 0
GRB14 -0.15 0.27 -10000 0 -0.59 55 55
ELK1 -0.003 0.25 -10000 0 -0.98 11 11
GRB7 0.004 0.073 -10000 0 -0.6 3 3
PAK1 0.013 0 -10000 0 -10000 0 0
Tie2/Ang1/alpha5/beta1 Integrin -0.12 0.27 -10000 0 -1.1 11 11
CDKN1A 0.029 0.19 -10000 0 -0.65 10 10
ITGA5 -0.01 0.11 -10000 0 -0.57 8 8
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.032 0.28 -10000 0 -1.1 11 11
CRK 0.013 0 -10000 0 -10000 0 0
mol:NO 0.024 0.19 -10000 0 -0.65 12 12
PLG -0.034 0.27 -10000 0 -1.1 11 11
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis 0.008 0.23 -10000 0 -0.86 11 11
GRB2 0.013 0 -10000 0 -10000 0 0
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
ANGPT2 0.008 0.17 -10000 0 -0.74 6 6
BMX -0.033 0.29 -10000 0 -1.1 11 11
ANGPT1 -0.038 0.26 -10000 0 -1.3 7 7
tube development 0.02 0.21 -10000 0 -0.67 14 14
ANGPT4 0.007 0.007 -10000 0 -10000 0 0
response to hypoxia -0.002 0.018 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.1 0.31 -10000 0 -1.2 11 11
alpha5/beta1 Integrin 0.002 0.083 -10000 0 -0.41 8 8
FGF2 -0.041 0.17 -10000 0 -0.57 19 19
STAT5A (dimer) 0.019 0.23 -10000 0 -0.79 12 12
mol:L-citrulline 0.024 0.19 -10000 0 -0.65 12 12
AGTR1 -0.031 0.15 -10000 0 -0.54 16 16
MAPK14 -0.011 0.28 -10000 0 -1.1 11 11
Tie2/SHP2 -0.04 0.18 -10000 0 -1.1 5 5
TEK -0.007 0.21 -10000 0 -1.3 5 5
RPS6KB1 0.014 0.23 -10000 0 -0.86 11 11
Angiotensin II/AT1 -0.02 0.11 -10000 0 -0.4 16 16
Tie2/Ang1/GRB2 -0.021 0.28 -10000 0 -1.1 11 11
MAPK3 -0.008 0.25 -10000 0 -1 11 11
MAPK1 -0.008 0.25 -10000 0 -1 11 11
Tie2/Ang1/GRB7 -0.026 0.28 -10000 0 -1.1 11 11
NFKB1 0.01 0.038 -10000 0 -0.54 1 1
MAPK8 -0.032 0.29 -10000 0 -1.1 11 11
PI3K 0 0.27 -10000 0 -1 11 11
FES -0.012 0.28 -10000 0 -1.1 11 11
Crk/Dok-R -0.027 0.28 -10000 0 -1.1 11 11
Tie2/Ang1/ABIN2 -0.021 0.28 -10000 0 -1.1 11 11
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity 0.016 0.22 -10000 0 -0.8 11 11
STAT5A 0.001 0.088 -10000 0 -0.62 4 4
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 0.014 0.23 -10000 0 -0.86 11 11
Tie2/Ang2 0.007 0.26 -10000 0 -0.91 13 13
Tie2/Ang1 -0.027 0.3 -10000 0 -1.2 11 11
FOXO1 0.017 0.22 -10000 0 -0.77 13 13
ELF1 0.015 0.047 -10000 0 -0.61 1 1
ELF2 -0.021 0.27 -10000 0 -1.1 11 11
mol:Choline -0.015 0.26 -10000 0 -1 11 11
cell migration -0.032 0.064 -10000 0 -0.24 13 13
FYN 0.014 0.23 -10000 0 -0.78 13 13
DOK2 -0.009 0.12 -10000 0 -0.62 7 7
negative regulation of cell cycle 0.032 0.18 -10000 0 -0.58 10 10
ETS1 -0.007 0.1 -10000 0 -0.59 5 5
PXN 0.026 0.2 -10000 0 -0.7 11 11
ITGB1 0.013 0 -10000 0 -10000 0 0
NOS3 0.02 0.21 -10000 0 -0.74 12 12
RAC1 0.013 0 -10000 0 -10000 0 0
TNF -0.045 0.18 -10000 0 -0.58 19 19
MAPKKK cascade -0.015 0.26 -10000 0 -1 11 11
RASA1 0.003 0.076 -10000 0 -0.62 3 3
Tie2/Ang1/Shc -0.02 0.28 -10000 0 -1.1 11 11
NCK1 0.013 0 -10000 0 -10000 0 0
vasculogenesis 0.027 0.17 -10000 0 -0.58 12 12
mol:Phosphatidic acid -0.015 0.26 -10000 0 -1 11 11
mol:Angiotensin II 0.001 0.004 -10000 0 -10000 0 0
mol:NADP 0.024 0.19 -10000 0 -0.65 12 12
Rac1/GTP -0.06 0.19 -10000 0 -0.8 11 11
MMP2 -0.031 0.29 -10000 0 -1.2 11 11
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.01 0.13 -10000 0 -0.4 12 12
CRKL -0.002 0.12 -10000 0 -0.42 9 9
HRAS 0.002 0.14 -10000 0 -0.49 7 7
mol:PIP3 -0.011 0.11 0.26 1 -0.38 9 10
SPRED1 0.013 0 -10000 0 -10000 0 0
SPRED2 0.003 0.076 -10000 0 -0.62 3 3
GAB1 -0.009 0.12 -10000 0 -0.41 12 12
FOXO3 0.002 0.11 -10000 0 -0.39 8 8
AKT1 -0.006 0.11 -10000 0 -0.41 9 9
BAD 0 0.11 -10000 0 -0.38 9 9
megakaryocyte differentiation -0.017 0.12 -10000 0 -0.39 14 14
GSK3B 0.002 0.11 -10000 0 -0.39 8 8
RAF1 0.013 0.11 -10000 0 -0.39 7 7
SHC1 0.013 0 -10000 0 -10000 0 0
STAT3 -0.006 0.11 -10000 0 -0.4 10 10
STAT1 -0.028 0.24 -10000 0 -0.87 12 12
HRAS/SPRED1 0.01 0.11 -10000 0 -0.39 7 7
cell proliferation -0.02 0.13 -10000 0 -0.35 19 19
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
TEC 0.013 0 -10000 0 -10000 0 0
RPS6KB1 -0.007 0.11 -10000 0 -0.41 10 10
HRAS/SPRED2 0.006 0.12 -10000 0 -0.39 7 7
LYN/TEC/p62DOK -0.034 0.093 -10000 0 -0.39 8 8
MAPK3 0.023 0.086 -10000 0 -0.27 7 7
STAP1 -0.03 0.14 -10000 0 -0.37 19 19
GRAP2 -0.023 0.14 -10000 0 -0.6 12 12
JAK2 -0.067 0.19 -10000 0 -0.74 12 12
STAT1 (dimer) -0.027 0.24 -10000 0 -0.85 12 12
mol:Gleevec -0.001 0.005 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.047 0.11 -10000 0 -0.4 10 10
actin filament polymerization -0.007 0.11 -10000 0 -0.38 11 11
LYN 0.01 0.044 -10000 0 -0.62 1 1
STAP1/STAT5A (dimer) -0.033 0.18 -10000 0 -0.55 13 13
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
CBL/CRKL/GRB2 0.009 0.11 -10000 0 -0.37 9 9
PI3K -0.008 0.12 -10000 0 -0.41 10 10
PTEN 0 0.088 -10000 0 -0.62 4 4
SCF/KIT/EPO/EPOR -0.041 0.3 -10000 0 -1.2 11 11
MAPK8 -0.021 0.13 -10000 0 -0.36 19 19
STAT3 (dimer) -0.006 0.11 -10000 0 -0.4 10 10
positive regulation of transcription 0.024 0.073 -10000 0 -0.24 1 1
mol:GDP -0.052 0.12 -10000 0 -0.51 8 8
PIK3C2B -0.006 0.11 -10000 0 -0.4 10 10
CBL/CRKL 0.003 0.11 -10000 0 -0.39 9 9
FER -0.011 0.12 -10000 0 -0.41 12 12
SH2B3 -0.006 0.11 -10000 0 -0.4 10 10
PDPK1 -0.007 0.11 -10000 0 -0.37 10 10
SNAI2 -0.052 0.17 -10000 0 -0.38 34 34
positive regulation of cell proliferation -0.018 0.19 -10000 0 -0.65 12 12
KITLG 0.012 0.046 -10000 0 -0.63 1 1
cell motility -0.018 0.19 -10000 0 -0.65 12 12
PTPN6 0.012 0.007 -10000 0 -10000 0 0
EPOR -0.004 0.17 -10000 0 -1.1 3 3
STAT5A (dimer) -0.015 0.16 -10000 0 -0.53 14 14
SOCS1 0.005 0.066 -10000 0 -0.54 3 3
cell migration 0.038 0.16 0.44 19 -10000 0 19
SOS1 0.013 0 -10000 0 -10000 0 0
EPO -0.001 0.085 -10000 0 -0.54 5 5
VAV1 -0.012 0.12 -10000 0 -0.62 8 8
GRB10 -0.014 0.13 -10000 0 -0.39 14 14
PTPN11 0.012 0.005 -10000 0 -10000 0 0
SCF/KIT -0.015 0.12 -10000 0 -0.42 11 11
GO:0007205 0 0.007 -10000 0 -10000 0 0
MAP2K1 0.02 0.093 -10000 0 -0.3 6 6
CBL 0.006 0.062 -10000 0 -0.62 2 2
KIT -0.04 0.28 -10000 0 -1.1 10 10
MAP2K2 0.02 0.093 -10000 0 -0.3 7 7
SHC/Grb2/SOS1 -0.032 0.091 -10000 0 -0.39 8 8
STAT5A -0.016 0.17 -10000 0 -0.54 14 14
GRB2 0.013 0 -10000 0 -10000 0 0
response to radiation -0.05 0.17 -10000 0 -0.37 35 35
SHC/GRAP2 -0.007 0.11 -10000 0 -0.43 12 12
PTPRO -0.018 0.13 -10000 0 -0.39 14 14
SH2B2 -0.008 0.12 -10000 0 -0.39 11 11
DOK1 0.013 0 -10000 0 -10000 0 0
MATK -0.039 0.16 -10000 0 -0.45 19 19
CREBBP 0.031 0.014 -10000 0 -10000 0 0
BCL2 0.015 0.097 -10000 0 -0.55 1 1
BARD1 signaling events

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 -0.032 0.15 -10000 0 -0.46 22 22
ATM 0.013 0 -10000 0 -10000 0 0
UBE2D3 0.013 0 -10000 0 -10000 0 0
PRKDC 0.013 0 -10000 0 -10000 0 0
ATR 0.013 0 -10000 0 -10000 0 0
UBE2L3 0.013 0 -10000 0 -10000 0 0
FANCD2 0.025 0 -10000 0 -10000 0 0
protein ubiquitination -0.033 0.097 -10000 0 -10000 0 0
XRCC5 0.013 0 -10000 0 -10000 0 0
XRCC6 0.013 0 -10000 0 -10000 0 0
M/R/N Complex 0.024 0.028 -10000 0 -0.38 1 1
MRE11A 0.013 0 -10000 0 -10000 0 0
DNA-PK 0.026 0 -10000 0 -10000 0 0
FA complex/FANCD2/Ubiquitin 0.037 0.042 -10000 0 -10000 0 0
FANCF -0.006 0.11 -10000 0 -0.62 6 6
BRCA1 0.013 0 -10000 0 -10000 0 0
CCNE1 0.013 0 -10000 0 -10000 0 0
CDK2/Cyclin E1 0.019 0 -10000 0 -10000 0 0
FANCG 0.013 0 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1 -0.032 0.15 -10000 0 -0.46 22 22
FANCE 0.013 0 -10000 0 -10000 0 0
FANCC 0.013 0 -10000 0 -10000 0 0
NBN 0.01 0.044 -10000 0 -0.62 1 1
FANCA 0.013 0 -10000 0 -10000 0 0
DNA repair 0.032 0.099 -10000 0 -10000 0 0
BRCA1/BARD1/ubiquitin -0.032 0.15 -10000 0 -0.46 22 22
BARD1/DNA-PK -0.007 0.12 -10000 0 -0.34 22 22
FANCL 0.013 0 -10000 0 -10000 0 0
mRNA polyadenylation 0.032 0.15 0.45 22 -10000 0 22
BRCA1/BARD1/CTIP/M/R/N Complex 0.006 0.093 -10000 0 -0.42 1 1
BRCA1/BACH1/BARD1/TopBP1 -0.018 0.13 -10000 0 -0.38 22 22
BRCA1/BARD1/P53 -0.009 0.12 -10000 0 -0.34 23 23
BARD1/CSTF1/BRCA1 -0.018 0.13 -10000 0 -0.38 22 22
BRCA1/BACH1 0.013 0 -10000 0 -10000 0 0
BARD1 -0.055 0.2 -10000 0 -0.62 22 22
PCNA 0.013 0 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH5C -0.018 0.13 -10000 0 -0.38 22 22
BRCA1/BARD1/UbcH7 -0.018 0.13 -10000 0 -0.38 22 22
BRCA1/BARD1/RAD51/PCNA -0.007 0.12 -10000 0 -0.34 22 22
BARD1/DNA-PK/P53 -0.002 0.11 -10000 0 -10000 0 0
BRCA1/BARD1/Ubiquitin -0.032 0.15 -10000 0 -0.46 22 22
BRCA1/BARD1/CTIP -0.008 0.12 -10000 0 -0.34 22 22
FA complex 0.031 0.042 -10000 0 -10000 0 0
BARD1/EWS -0.032 0.15 -10000 0 -0.46 22 22
RBBP8 0.022 0 -10000 0 -10000 0 0
TP53 0.01 0.044 -10000 0 -0.62 1 1
TOPBP1 0.013 0 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle 0.01 0.12 0.34 23 -10000 0 23
BRCA1/BARD1 0 0.11 -10000 0 -10000 0 0
CSTF1 0.013 0 -10000 0 -10000 0 0
BARD1/EWS-Fli1 -0.041 0.15 -10000 0 -0.46 22 22
CDK2 0.013 0 -10000 0 -10000 0 0
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.013 0 -10000 0 -10000 0 0
RAD50 0.013 0 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme -0.032 0.15 -10000 0 -0.46 22 22
EWSR1 0.013 0 -10000 0 -10000 0 0
TRAIL signaling pathway

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 -0.035 0.16 -10000 0 -0.6 16 16
positive regulation of NF-kappaB transcription factor activity -0.031 0.15 -10000 0 -0.47 21 21
MAP2K4 0.021 0.081 -10000 0 -0.57 1 1
IKBKB 0.013 0 -10000 0 -10000 0 0
TNFRSF10B 0.01 0.044 -10000 0 -0.62 1 1
TNFRSF10A 0.01 0.044 -10000 0 -0.62 1 1
SMPD1 -0.002 0.071 -10000 0 -0.24 14 14
IKBKG 0.013 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D -0.009 0.11 -10000 0 -0.61 7 7
TRAIL/TRAILR2 -0.019 0.13 -10000 0 -0.44 17 17
TRAIL/TRAILR3 -0.044 0.17 -10000 0 -0.48 26 26
TRAIL/TRAILR1 -0.019 0.13 -10000 0 -0.44 17 17
TRAIL/TRAILR4 -0.031 0.15 -10000 0 -0.48 21 21
TRAIL/TRAILR1/DAP3/GTP -0.005 0.099 -10000 0 -0.34 17 17
IKK complex -0.011 0.035 -10000 0 -10000 0 0
RIPK1 0.013 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP 0.009 0 -10000 0 -10000 0 0
MAPK3 -0.014 0.12 -10000 0 -0.44 16 16
MAP3K1 0.016 0.076 -10000 0 -10000 0 0
TRAILR4 (trimer) -0.008 0.11 -10000 0 -0.61 7 7
TRADD 0.013 0 -10000 0 -10000 0 0
TRAILR1 (trimer) 0.01 0.044 -10000 0 -0.62 1 1
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 0.012 0.076 -10000 0 -10000 0 0
CFLAR 0.013 0 -10000 0 -10000 0 0
MAPK1 -0.014 0.12 -10000 0 -0.44 16 16
TRAIL/TRAILR1/FADD/TRADD/RIP 0.008 0.096 -10000 0 -10000 0 0
mol:ceramide -0.002 0.07 -10000 0 -0.24 14 14
FADD 0.01 0.038 -10000 0 -0.54 1 1
MAPK8 0.013 0.11 -10000 0 -0.47 4 4
TRAF2 0.013 0 -10000 0 -10000 0 0
TRAILR3 (trimer) -0.026 0.15 -10000 0 -0.6 13 13
CHUK 0.013 0 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD -0.008 0.11 -10000 0 -0.36 18 18
DAP3 0.013 0 -10000 0 -10000 0 0
CASP10 -0.032 0.12 0.27 3 -0.43 14 17
JNK cascade -0.031 0.15 -10000 0 -0.47 21 21
TRAIL (trimer) -0.035 0.16 -10000 0 -0.6 16 16
TNFRSF10C -0.026 0.15 -10000 0 -0.6 13 13
TRAIL/TRAILR1/DAP3/GTP/FADD 0.001 0.096 -10000 0 -0.32 13 13
TRAIL/TRAILR2/FADD -0.008 0.11 -10000 0 -0.36 18 18
cell death -0.002 0.07 -10000 0 -0.24 14 14
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.012 0.076 -10000 0 -10000 0 0
TRAILR2 (trimer) 0.01 0.044 -10000 0 -0.62 1 1
CASP8 0.006 0.064 -10000 0 -0.77 1 1
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.008 0.096 -10000 0 -10000 0 0
Signaling mediated by p38-gamma and p38-delta

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K 0.026 0.029 -9999 0 -0.38 1 1
SNTA1 0.013 0 -9999 0 -10000 0 0
response to hypoxia 0 0 -9999 0 -10000 0 0
STMN1 0.024 0.04 -9999 0 -0.38 2 2
MAPK12 -0.011 0.11 -9999 0 -0.33 22 22
CCND1 -0.018 0.11 -9999 0 -0.44 9 9
p38 gamma/SNTA1 -0.004 0.11 -9999 0 -0.34 13 13
MAP2K3 0.013 0 -9999 0 -10000 0 0
PKN1 -0.005 0.1 -9999 0 -0.6 6 6
G2/M transition checkpoint -0.011 0.11 -9999 0 -0.33 22 22
MAP2K6 -0.013 0.11 -9999 0 -0.36 18 18
MAPT -0.015 0.094 -9999 0 -0.35 8 8
MAPK13 0.019 0.033 -9999 0 -0.46 1 1
hyperosmotic response 0 0 -9999 0 -10000 0 0
ZAK 0.007 0.057 -9999 0 -0.32 6 6
IL2 signaling events mediated by PI3K

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.001 0.16 -10000 0 -0.79 4 4
UGCG -0.039 0.19 -10000 0 -0.68 15 15
AKT1/mTOR/p70S6K/Hsp90/TERT -0.011 0.16 -10000 0 -0.44 13 13
mol:GTP 0 0.001 -10000 0 -10000 0 0
mol:glucosylceramide -0.038 0.18 -10000 0 -0.67 15 15
mol:DAG 0 0.014 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.066 0.15 -10000 0 -0.47 18 18
FRAP1 -0.011 0.21 -10000 0 -0.55 18 18
FOXO3 -0.008 0.2 -10000 0 -0.55 17 17
AKT1 -0.017 0.22 -10000 0 -0.51 27 27
GAB2 0.009 0.039 -10000 0 -0.55 1 1
SMPD1 0.008 0.064 -10000 0 -0.73 1 1
SGMS1 0.011 0.037 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP 0.002 0.077 -10000 0 -0.35 9 9
CALM1 0.013 0 -10000 0 -10000 0 0
cell proliferation -0.026 0.17 -10000 0 -0.32 35 35
EIF3A 0.013 0 -10000 0 -10000 0 0
PI3K 0.002 0.09 -10000 0 -0.42 9 9
RPS6KB1 0.011 0.047 -10000 0 -10000 0 0
mol:sphingomyelin 0 0.014 -10000 0 -10000 0 0
natural killer cell activation 0 0.003 -10000 0 -0.012 11 11
JAK3 -0.001 0.095 -10000 0 -0.6 5 5
PIK3R1 -0.009 0.11 -10000 0 -0.57 8 8
JAK1 0.014 0.005 -10000 0 -10000 0 0
NFKB1 0.01 0.038 -10000 0 -0.54 1 1
MYC -0.064 0.34 -10000 0 -0.91 26 26
MYB -0.016 0.23 -10000 0 -1.2 7 7
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.009 0.19 -10000 0 -0.54 16 16
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.023 0.047 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.008 0.18 -10000 0 -0.52 16 16
Rac1/GDP 0.009 0.07 -10000 0 -0.31 9 9
T cell proliferation 0.001 0.17 -10000 0 -0.55 11 11
SHC1 0.012 0.004 -10000 0 -10000 0 0
RAC1 0.013 0.001 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity 0.002 0.014 -10000 0 -0.06 9 9
PRKCZ -0.001 0.18 -10000 0 -0.58 11 11
NF kappa B1 p50/RelA -0.066 0.15 -10000 0 -0.49 14 14
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.007 0.16 -10000 0 -0.59 10 10
HSP90AA1 0.013 0 -10000 0 -10000 0 0
RELA 0.013 0 -10000 0 -10000 0 0
IL2RA -0.03 0.16 -10000 0 -0.6 14 14
IL2RB -0.019 0.14 -10000 0 -0.6 11 11
TERT -0.058 0.19 -10000 0 -0.59 24 24
E2F1 0.009 0.087 -10000 0 -0.39 9 9
SOS1 0.012 0.004 -10000 0 -10000 0 0
RPS6 0.01 0.038 -10000 0 -0.54 1 1
mol:cAMP -0.001 0.007 0.029 9 -10000 0 9
PTPN11 0.012 0.004 -10000 0 -10000 0 0
IL2RG -0.038 0.17 -10000 0 -0.58 18 18
actin cytoskeleton organization 0.001 0.17 -10000 0 -0.55 11 11
GRB2 0.012 0.004 -10000 0 -10000 0 0
IL2 -0.001 0.066 -10000 0 -0.54 3 3
PIK3CA 0.011 0.045 -10000 0 -0.63 1 1
Rac1/GTP 0.016 0.069 -10000 0 -0.3 9 9
LCK -0.004 0.1 -10000 0 -0.59 6 6
BCL2 0.005 0.17 -10000 0 -0.49 11 11
S1P4 pathway

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
GNAO1 -0.016 0.13 -9999 0 -0.57 10 10
CDC42/GTP -0.018 0.11 -9999 0 -0.42 6 6
PLCG1 -0.018 0.12 -9999 0 -0.44 6 6
mol:GTP 0 0 -9999 0 -10000 0 0
GNAI2 0.013 0 -9999 0 -10000 0 0
GNAI3 0.013 0 -9999 0 -10000 0 0
G12/G13 0.019 0 -9999 0 -10000 0 0
cell migration -0.045 0.096 -9999 0 -0.42 6 6
S1PR5 -0.1 0.24 -9999 0 -0.62 37 37
S1PR4 -0.016 0.13 -9999 0 -0.57 10 10
MAPK3 -0.018 0.12 -9999 0 -0.44 6 6
MAPK1 -0.018 0.12 -9999 0 -0.44 6 6
S1P/S1P5/Gi -0.067 0.17 -9999 0 -0.51 15 15
GNAI1 -0.021 0.14 -9999 0 -0.62 11 11
CDC42/GDP 0.009 0 -9999 0 -10000 0 0
S1P/S1P5/G12 -0.056 0.16 -9999 0 -0.39 37 37
RHOA 0.015 0.068 -9999 0 -0.32 4 4
S1P/S1P4/Gi -0.027 0.12 -9999 0 -0.38 11 11
mol:GDP 0 0 -9999 0 -10000 0 0
GNAZ -0.055 0.19 -9999 0 -0.59 23 23
S1P/S1P4/G12/G13 0.008 0.073 -9999 0 -0.31 10 10
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
Ras signaling in the CD4+ TCR pathway

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.014 0.19 -9999 0 -0.71 10 10
MAP3K8 0.006 0.062 -9999 0 -0.62 2 2
FOS -0.013 0.18 -9999 0 -0.73 10 10
PRKCA 0.004 0.073 -9999 0 -0.59 3 3
PTPN7 -0.017 0.14 -9999 0 -0.62 10 10
HRAS 0.013 0.001 -9999 0 -10000 0 0
PRKCB -0.029 0.15 -9999 0 -0.6 14 14
NRAS 0.013 0.001 -9999 0 -10000 0 0
RAS family/GTP 0.022 0.023 -9999 0 -0.29 1 1
MAPK3 -0.013 0.16 -9999 0 -0.7 10 10
MAP2K1 0.002 0.12 -9999 0 -0.45 12 12
ELK1 0.012 0.006 -9999 0 -10000 0 0
BRAF -0.003 0.11 -9999 0 -0.43 12 12
mol:GTP 0 0.002 -9999 0 -0.005 18 18
MAPK1 -0.013 0.16 -9999 0 -0.7 10 10
RAF1 -0.003 0.11 -9999 0 -0.43 12 12
KRAS 0.01 0.038 -9999 0 -0.54 1 1
Regulation of nuclear SMAD2/3 signaling

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.014 0.046 -10000 0 -0.62 1 1
HSPA8 0.012 0.004 -10000 0 -10000 0 0
SMAD3/SMAD4/ER alpha -0.047 0.17 0.21 7 -0.39 32 39
AKT1 0.014 0.012 -10000 0 -10000 0 0
GSC -0.16 0.36 -10000 0 -1.3 13 13
NKX2-5 -0.16 0.26 -10000 0 -0.57 60 60
muscle cell differentiation 0.054 0.099 0.47 4 -10000 0 4
SMAD2-3/SMAD4/SP1 0.025 0.09 -10000 0 -0.37 1 1
SMAD4 0 0.086 -10000 0 -0.64 3 3
CBFB 0.013 0 -10000 0 -10000 0 0
SAP18 0.012 0.001 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.006 0.094 -10000 0 -0.38 10 10
SMAD3/SMAD4/VDR 0.01 0.085 -10000 0 -10000 0 0
MYC -0.056 0.19 -10000 0 -0.62 22 22
CDKN2B 0.011 0.2 -10000 0 -1.3 4 4
AP1 0.018 0.11 -10000 0 -0.48 2 2
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.034 0.056 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 0.02 0.079 -10000 0 -0.44 3 3
SP3 0.012 0.044 -10000 0 -0.62 1 1
CREB1 0.013 0 -10000 0 -10000 0 0
FOXH1 -0.022 0.11 -10000 0 -0.56 7 7
SMAD3/SMAD4/GR -0.004 0.082 -10000 0 -0.38 7 7
GATA3 -0.064 0.2 -10000 0 -0.6 25 25
SKI/SIN3/HDAC complex/NCoR1 0.03 0.037 -10000 0 -10000 0 0
MEF2C/TIF2 -0.12 0.2 -10000 0 -0.61 13 13
endothelial cell migration 0.053 0.28 1.3 8 -10000 0 8
MAX 0.015 0.013 -10000 0 -10000 0 0
RBBP7 0.01 0.039 -10000 0 -0.54 1 1
RBBP4 0 0.088 -10000 0 -0.62 4 4
RUNX2 0 0.088 -10000 0 -0.62 4 4
RUNX3 -0.003 0.098 -10000 0 -0.62 5 5
RUNX1 0.01 0.044 -10000 0 -0.62 1 1
CTBP1 0.013 0 -10000 0 -10000 0 0
NR3C1 0.002 0.086 -10000 0 -0.6 4 4
VDR -0.009 0.12 -10000 0 -0.62 7 7
CDKN1A 0.039 0.12 -10000 0 -1.4 1 1
KAT2B 0.011 0.044 -10000 0 -0.62 1 1
SMAD2/SMAD2/SMAD4/FOXH1 -0.026 0.11 -10000 0 -0.41 9 9
DCP1A 0.013 0 -10000 0 -10000 0 0
SKI 0.012 0.001 -10000 0 -10000 0 0
SERPINE1 -0.053 0.28 -10000 0 -1.3 8 8
SMAD3/SMAD4/ATF2 -0.001 0.072 -10000 0 -0.39 4 4
SMAD3/SMAD4/ATF3 -0.015 0.1 -10000 0 -0.38 13 13
SAP30 0.012 0.001 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.026 0.049 -10000 0 -0.38 1 1
JUN 0.017 0.11 -10000 0 -0.48 2 2
SMAD3/SMAD4/IRF7 -0.002 0.077 -10000 0 -0.38 4 4
TFE3 0.016 0.013 -10000 0 -10000 0 0
COL1A2 -0.043 0.23 -10000 0 -0.66 21 21
mesenchymal cell differentiation 0.005 0.083 0.38 8 -10000 0 8
DLX1 -0.092 0.22 -10000 0 -0.56 37 37
TCF3 0.013 0 -10000 0 -10000 0 0
FOS -0.036 0.17 -10000 0 -0.56 19 19
SMAD3/SMAD4/Max 0.004 0.061 -10000 0 -0.35 4 4
Cbp/p300/SNIP1 0.027 0.032 -10000 0 -0.38 1 1
ZBTB17 0.012 0.008 -10000 0 -10000 0 0
LAMC1 0.035 0.059 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 -0.002 0.079 -10000 0 -0.39 6 6
IRF7 0.006 0.064 -10000 0 -0.62 2 2
ESR1 -0.081 0.22 -10000 0 -0.59 33 33
HNF4A -0.071 0.2 -10000 0 -0.54 30 30
MEF2C -0.094 0.19 -10000 0 -0.57 9 9
SMAD2-3/SMAD4 -0.005 0.073 -10000 0 -0.4 3 3
Cbp/p300/Src-1 0.03 0.036 -10000 0 -0.38 1 1
IGHV3OR16-13 -0.004 0.017 -10000 0 -10000 0 0
TGIF2/HDAC complex 0.003 0.076 -10000 0 -0.62 3 3
CREBBP 0.016 0.009 -10000 0 -10000 0 0
SKIL 0.01 0.044 -10000 0 -0.62 1 1
HDAC1 0.012 0.001 -10000 0 -10000 0 0
HDAC2 0.012 0.001 -10000 0 -10000 0 0
SNIP1 0.012 0.003 -10000 0 -10000 0 0
GCN5L2 0.003 0.011 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.038 0.069 -10000 0 -0.37 2 2
MSG1/HSC70 -0.006 0.091 -10000 0 -0.4 10 10
SMAD2 -0.003 0.053 -10000 0 -0.61 1 1
SMAD3 0.019 0.053 -10000 0 -0.59 1 1
SMAD3/E2F4-5/DP1/p107/SMAD4 0.019 0.089 -10000 0 -0.43 3 3
SMAD2/SMAD2/SMAD4 0.003 0.059 -10000 0 -0.38 4 4
NCOR1 0.012 0.001 -10000 0 -10000 0 0
NCOA2 -0.058 0.2 -10000 0 -0.62 23 23
NCOA1 0.013 0 -10000 0 -10000 0 0
MYOD/E2A 0.003 0.055 -10000 0 -0.38 4 4
SMAD2-3/SMAD4/SP1/MIZ-1 0.033 0.086 -10000 0 -10000 0 0
IFNB1 0.021 0.092 -10000 0 -0.49 3 3
SMAD3/SMAD4/MEF2C -0.078 0.18 -10000 0 -0.69 4 4
CITED1 -0.016 0.12 -10000 0 -0.56 10 10
SMAD2-3/SMAD4/ARC105 0.019 0.072 -10000 0 -0.38 2 2
RBL1 -0.003 0.098 -10000 0 -0.62 5 5
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB 0.037 0.096 -10000 0 -0.55 4 4
RUNX1-3/PEBPB2 0.014 0.069 -10000 0 -0.38 6 6
SMAD7 0.038 0.098 -10000 0 -10000 0 0
MYC/MIZ-1 -0.044 0.14 -10000 0 -0.45 22 22
SMAD3/SMAD4 0.027 0.13 0.28 8 -0.42 6 14
IL10 -0.027 0.19 -10000 0 -0.66 9 9
PIASy/HDAC complex 0.011 0.01 -10000 0 -10000 0 0
PIAS3 0.014 0.005 -10000 0 -10000 0 0
CDK2 0.016 0.009 -10000 0 -10000 0 0
IL5 -0.024 0.16 -10000 0 -0.5 7 7
CDK4 0.016 0.01 -10000 0 -10000 0 0
PIAS4 0.011 0.01 -10000 0 -10000 0 0
ATF3 -0.016 0.13 -10000 0 -0.57 10 10
SMAD3/SMAD4/SP1 0.025 0.088 -10000 0 -0.36 3 3
FOXG1 -0.04 0.14 -10000 0 -0.54 16 16
FOXO3 0.024 0.016 -10000 0 -10000 0 0
FOXO1 0.021 0.037 -10000 0 -0.45 1 1
FOXO4 0.024 0.016 -10000 0 -10000 0 0
heart looping -0.093 0.18 -10000 0 -0.56 9 9
CEBPB 0.013 0.006 -10000 0 -10000 0 0
SMAD3/SMAD4/DLX1 -0.061 0.15 -10000 0 -0.36 36 36
MYOD1 -0.009 0.075 -10000 0 -0.54 4 4
SMAD3/SMAD4/HNF4 -0.047 0.14 -10000 0 -0.37 32 32
SMAD3/SMAD4/GATA3 -0.051 0.15 -10000 0 -0.43 19 19
SnoN/SIN3/HDAC complex/NCoR1 0.01 0.044 -10000 0 -0.62 1 1
SMAD3/SMAD4/RUNX1-3/PEBPB2 0.029 0.087 -10000 0 -0.58 1 1
SMAD3/SMAD4/SP1-3 0.036 0.085 -10000 0 -10000 0 0
MED15 0.013 0 -10000 0 -10000 0 0
SP1 0.009 0.042 -10000 0 -10000 0 0
SIN3B 0.012 0.001 -10000 0 -10000 0 0
SIN3A 0.012 0.001 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 -0.11 0.19 -10000 0 -0.46 22 22
ITGB5 0.038 0.084 -10000 0 -0.57 1 1
TGIF/SIN3/HDAC complex/CtBP 0.039 0.031 -10000 0 -10000 0 0
SMAD3/SMAD4/AR -0.065 0.16 -10000 0 -0.36 41 41
AR -0.095 0.22 -10000 0 -0.56 38 38
negative regulation of cell growth 0.023 0.092 -10000 0 -0.38 5 5
SMAD3/SMAD4/MYOD -0.006 0.076 -10000 0 -0.35 6 6
E2F5 -0.013 0.12 -10000 0 -0.58 9 9
E2F4 0.013 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF -0.001 0.1 -10000 0 -0.49 3 3
SMAD2-3/SMAD4/FOXO1-3a-4 0.032 0.074 -10000 0 -0.36 4 4
TFDP1 0.013 0 -10000 0 -10000 0 0
SMAD3/SMAD4/AP1 0.02 0.11 -10000 0 -0.49 2 2
SMAD3/SMAD4/RUNX2 -0.005 0.084 -10000 0 -0.38 8 8
TGIF2 0.003 0.076 -10000 0 -0.62 3 3
TGIF1 0.013 0 -10000 0 -10000 0 0
ATF2 0.006 0.062 -10000 0 -0.62 2 2
a4b1 and a4b7 Integrin signaling

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.013 0 -9999 0 -10000 0 0
ITGB7 -0.003 0.098 -9999 0 -0.62 5 5
ITGA4 -0.009 0.11 -9999 0 -0.61 7 7
alpha4/beta7 Integrin -0.008 0.12 -9999 0 -0.48 11 11
alpha4/beta1 Integrin 0.003 0.084 -9999 0 -0.44 7 7
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0 0.092 -10000 0 -0.46 8 8
CRKL 0.002 0.096 -10000 0 -0.44 3 3
mol:PIP3 -0.008 0.078 0.54 4 -10000 0 4
AKT1 0.005 0.064 0.38 4 -0.37 2 6
PTK2B 0.013 0 -10000 0 -10000 0 0
RAPGEF1 0.009 0.092 -10000 0 -0.42 3 3
RANBP10 0.013 0 -10000 0 -10000 0 0
PIK3CA 0.01 0.044 -10000 0 -0.62 1 1
HGF/MET/SHIP2 -0.022 0.13 -10000 0 -0.37 25 25
MAP3K5 0.002 0.12 -10000 0 -0.46 6 6
HGF/MET/CIN85/CBL/ENDOPHILINS -0.016 0.13 -10000 0 -0.36 21 21
AP1 -0.024 0.12 -10000 0 -0.38 20 20
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.013 0 -10000 0 -10000 0 0
apoptosis -0.026 0.17 -10000 0 -0.82 8 8
STAT3 (dimer) 0.005 0.092 -10000 0 -10000 0 0
GAB1/CRKL/SHP2/PI3K -0.036 0.087 -10000 0 -0.37 6 6
INPP5D 0.006 0.062 -10000 0 -0.62 2 2
CBL/CRK 0.006 0.099 -10000 0 -0.4 5 5
PTPN11 0.013 0 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.013 0 -10000 0 -10000 0 0
PTEN 0 0.088 -10000 0 -0.62 4 4
ELK1 -0.008 0.043 -10000 0 -0.22 8 8
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 -0.02 0.061 -10000 0 -0.59 1 1
PAK1 0.011 0.059 0.35 4 -0.34 2 6
HGF/MET/RANBP10 -0.022 0.13 -10000 0 -0.37 25 25
HRAS -0.014 0.15 -10000 0 -0.66 8 8
DOCK1 0.006 0.099 -10000 0 -0.4 5 5
GAB1 -0.005 0.1 -10000 0 -0.34 10 10
CRK 0.002 0.096 -10000 0 -0.44 3 3
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP -0.054 0.16 -10000 0 -0.54 19 19
JUN 0.01 0.044 -10000 0 -0.62 1 1
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET -0.016 0.093 -10000 0 -0.27 19 19
PIK3R1 -0.01 0.11 -10000 0 -0.57 8 8
cell morphogenesis 0.016 0.11 -10000 0 -0.43 2 2
GRB2/SHC 0.001 0.084 -10000 0 -0.69 1 1
FOS -0.041 0.17 -10000 0 -0.57 19 19
GLMN 0 0 -10000 0 -10000 0 0
cell motility -0.008 0.043 -10000 0 -0.22 8 8
HGF/MET/MUC20 -0.031 0.13 -10000 0 -0.38 25 25
cell migration 0.001 0.082 -10000 0 -0.67 1 1
GRB2 0.013 0 -10000 0 -10000 0 0
CBL 0.006 0.062 -10000 0 -0.62 2 2
MET/RANBP10 0 0.092 -10000 0 -0.46 8 8
HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.002 0.095 -10000 0 -10000 0 0
MET/MUC20 -0.009 0.091 -10000 0 -0.46 8 8
RAP1B 0.016 0.087 -10000 0 -0.39 3 3
RAP1A 0.014 0.091 -10000 0 -0.38 4 4
HGF/MET/RANBP9 -0.022 0.13 -10000 0 -0.37 25 25
RAF1 -0.006 0.14 -10000 0 -0.61 8 8
STAT3 0.005 0.093 -10000 0 -10000 0 0
cell proliferation 0.005 0.13 -10000 0 -0.37 19 19
RPS6KB1 0.002 0.034 -10000 0 -0.23 1 1
MAPK3 -0.012 0.039 -10000 0 -0.2 7 7
MAPK1 -0.012 0.039 -10000 0 -10000 0 0
RANBP9 0.013 0 -10000 0 -10000 0 0
MAPK8 -0.003 0.16 -10000 0 -0.52 12 12
SRC 0.006 0.09 -10000 0 -10000 0 0
PI3K -0.012 0.1 -10000 0 -0.3 17 17
MET/Glomulin -0.004 0.081 -10000 0 -0.41 8 8
SOS1 0.013 0 -10000 0 -10000 0 0
MAP2K1 0.002 0.14 -10000 0 -0.56 8 8
MET -0.012 0.12 -10000 0 -0.62 8 8
MAP4K1 -0.001 0.12 -10000 0 -0.49 5 5
PTK2 0.013 0 -10000 0 -10000 0 0
MAP2K2 0.002 0.14 -10000 0 -0.56 8 8
BAD 0.01 0.069 0.35 4 -0.48 2 6
MAP2K4 0.008 0.11 -10000 0 -0.42 7 7
SHP2/GRB2/SOS1/GAB1 -0.031 0.091 -10000 0 -0.38 10 10
INPPL1 0.013 0 -10000 0 -10000 0 0
PXN 0.013 0 -10000 0 -10000 0 0
SH3KBP1 0.01 0.044 -10000 0 -0.62 1 1
HGS -0.007 0.087 -10000 0 -0.32 8 8
PLCgamma1/PKC 0.009 0 -10000 0 -10000 0 0
HGF -0.038 0.17 -10000 0 -0.59 17 17
RASA1 0.003 0.076 -10000 0 -0.62 3 3
NCK1 0.013 0 -10000 0 -10000 0 0
PTPRJ 0.01 0.044 -10000 0 -0.62 1 1
NCK/PLCgamma1 0.002 0.087 -10000 0 -0.68 1 1
PDPK1 -0.003 0.072 0.42 4 -0.4 2 6
HGF/MET/SHIP -0.026 0.13 -10000 0 -0.37 27 27
IFN-gamma pathway

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.041 0.14 -9999 0 -0.39 9 9
positive regulation of NF-kappaB transcription factor activity 0 0.001 -9999 0 -10000 0 0
CRKL 0.013 0 -9999 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 -0.013 0.15 -9999 0 -0.67 3 3
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.016 0.05 -9999 0 -0.39 3 3
antigen processing and presentation of peptide antigen via MHC class I -0.061 0.096 -9999 0 -0.36 10 10
CaM/Ca2+ -0.064 0.12 -9999 0 -0.45 4 4
RAP1A 0.01 0.044 -9999 0 -0.62 1 1
STAT1 (dimer)/SHP2 -0.032 0.14 -9999 0 -0.49 4 4
AKT1 -0.029 0.14 -9999 0 -0.48 5 5
MAP2K1 -0.025 0.13 -9999 0 -0.55 2 2
MAP3K11 -0.033 0.14 -9999 0 -0.46 4 4
IFNGR1 0.007 0.014 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKII -0.1 0.17 -9999 0 -0.53 21 21
Rap1/GTP -0.05 0.093 -9999 0 -0.49 2 2
CRKL/C3G 0.019 0 -9999 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP -0.043 0.15 -9999 0 -0.46 4 4
CEBPB -0.012 0.17 -9999 0 -0.58 8 8
STAT3 0.013 0 -9999 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.036 0.14 -9999 0 -0.59 2 2
STAT1 -0.032 0.14 -9999 0 -0.49 4 4
CALM1 0.013 0 -9999 0 -10000 0 0
IFN-gamma (dimer) -0.13 0.26 -9999 0 -0.59 49 49
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
STAT1 (dimer)/PIAS1 -0.024 0.13 -9999 0 -0.46 4 4
CEBPB/PTGES2/Cbp/p300 -0.044 0.096 -9999 0 -0.51 4 4
mol:Ca2+ -0.042 0.14 -9999 0 -0.39 9 9
MAPK3 -0.014 0.13 -9999 0 -0.53 2 2
STAT1 (dimer) -0.082 0.14 -9999 0 -0.52 10 10
MAPK1 -0.014 0.13 -9999 0 -0.66 1 1
JAK2 -0.001 0.073 -9999 0 -0.59 3 3
PIK3R1 -0.01 0.11 -9999 0 -0.57 8 8
JAK1 0.007 0.014 -9999 0 -10000 0 0
CAMK2D 0.01 0.044 -9999 0 -0.62 1 1
DAPK1 -0.007 0.16 -9999 0 -0.54 12 12
SMAD7 0 0.07 -9999 0 -0.21 1 1
CBL/CRKL/C3G -0.021 0.13 -9999 0 -0.51 2 2
PI3K -0.072 0.13 -9999 0 -0.47 7 7
IFNG -0.13 0.26 -9999 0 -0.59 49 49
apoptosis -0.012 0.12 -9999 0 -0.39 12 12
CAMK2G 0.013 0 -9999 0 -10000 0 0
STAT3 (dimer) 0.013 0 -9999 0 -10000 0 0
CAMK2A -0.052 0.19 -9999 0 -0.59 22 22
CAMK2B -0.12 0.25 -9999 0 -0.58 46 46
FRAP1 -0.026 0.13 -9999 0 -0.44 5 5
PRKCD -0.028 0.14 -9999 0 -0.49 5 5
RAP1B 0.013 0 -9999 0 -10000 0 0
negative regulation of cell growth -0.061 0.096 -9999 0 -0.36 10 10
PTPN2 0.013 0 -9999 0 -10000 0 0
EP300 0.01 0.044 -9999 0 -0.62 1 1
IRF1 -0.002 0.14 -9999 0 -0.64 5 5
STAT1 (dimer)/PIASy -0.026 0.13 -9999 0 -0.47 4 4
SOCS1 0.001 0.052 -9999 0 -10000 0 0
mol:GDP -0.057 0.1 -9999 0 -0.48 2 2
CASP1 -0.011 0.1 -9999 0 -0.34 12 12
PTGES2 0.013 0 -9999 0 -10000 0 0
IRF9 0.023 0.062 -9999 0 -0.4 1 1
mol:PI-3-4-5-P3 -0.07 0.12 -9999 0 -0.46 7 7
RAP1/GDP -0.05 0.094 -9999 0 -0.5 2 2
CBL -0.036 0.14 -9999 0 -0.46 4 4
MAP3K1 -0.034 0.14 -9999 0 -0.4 7 7
PIAS1 0.013 0 -9999 0 -10000 0 0
PIAS4 0.012 0.001 -9999 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.061 0.096 -9999 0 -0.36 10 10
PTPN11 -0.042 0.14 -9999 0 -0.39 9 9
CREBBP 0.013 0.001 -9999 0 -10000 0 0
RAPGEF1 0.013 0 -9999 0 -10000 0 0
RXR and RAR heterodimerization with other nuclear receptor

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.023 0.19 -10000 0 -1.2 5 5
VDR -0.009 0.12 -10000 0 -0.62 7 7
FAM120B 0.013 0 -10000 0 -10000 0 0
RXRs/LXRs/DNA/9cRA 0.026 0.085 -10000 0 -0.43 1 1
RXRs/LXRs/DNA/Oxysterols 0.026 0.11 -10000 0 -0.4 7 7
MED1 0.013 0 -10000 0 -10000 0 0
mol:9cRA 0.003 0.014 -10000 0 -10000 0 0
RARs/THRs/DNA/Src-1 -0.026 0.13 -10000 0 -0.6 3 3
RXRs/NUR77 -0.013 0.12 -10000 0 -0.36 8 8
RXRs/PPAR -0.015 0.11 -10000 0 -0.41 4 4
NCOR2 0.013 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 -0.007 0.086 -10000 0 -0.46 7 7
RARs/VDR/DNA/Vit D3 -0.026 0.13 -10000 0 -0.33 31 31
RARA 0.013 0 -10000 0 -10000 0 0
NCOA1 0.013 0 -10000 0 -10000 0 0
VDR/VDR/DNA -0.009 0.12 -10000 0 -0.62 7 7
RARs/RARs/DNA/9cRA -0.02 0.12 -10000 0 -0.33 26 26
RARG 0.01 0.044 -10000 0 -0.62 1 1
RPS6KB1 -0.001 0.069 -10000 0 -0.41 5 5
RARs/THRs/DNA/SMRT -0.026 0.13 -10000 0 -0.6 3 3
THRA 0.013 0 -10000 0 -10000 0 0
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA -0.007 0.086 -10000 0 -0.46 7 7
RXRs/PPAR/9cRA/PGJ2/DNA 0.017 0.089 0.3 3 -0.33 2 5
NR1H4 -0.013 0.091 -10000 0 -0.54 6 6
RXRs/LXRs/DNA 0.031 0.092 -10000 0 -0.46 1 1
NR1H2 0.016 0.01 -10000 0 -10000 0 0
NR1H3 0.013 0.044 -10000 0 -0.6 1 1
RXRs/VDR/DNA/Vit D3 0.008 0.12 -10000 0 -0.5 7 7
NR4A1 -0.046 0.17 -10000 0 -0.56 21 21
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 0.012 0.053 -10000 0 -10000 0 0
RXRG -0.015 0.12 -10000 0 -0.53 10 10
RXR alpha/CCPG 0.017 0.047 -10000 0 -0.45 2 2
RXRA 0.01 0.063 -10000 0 -0.62 2 2
RXRB 0.016 0.012 -10000 0 -10000 0 0
THRB -0.04 0.18 -10000 0 -0.62 17 17
PPARG -0.087 0.22 -10000 0 -0.56 36 36
PPARD 0.01 0.044 -10000 0 -0.62 1 1
TNF -0.004 0.23 -10000 0 -1 8 8
mol:Oxysterols 0.003 0.012 -10000 0 -10000 0 0
cholesterol transport 0.026 0.11 -10000 0 -0.4 7 7
PPARA 0.006 0.062 -10000 0 -0.62 2 2
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB -0.064 0.21 -10000 0 -0.62 25 25
RXRs/NUR77/BCL2 -0.006 0.082 -10000 0 -0.27 8 8
SREBF1 0.033 0.1 -10000 0 -0.51 1 1
RXRs/RXRs/DNA/9cRA 0.017 0.089 0.29 3 -0.33 2 5
ABCA1 0.03 0.13 -10000 0 -1.2 1 1
RARs/THRs -0.035 0.15 -10000 0 -0.34 39 39
RXRs/FXR 0.005 0.092 -10000 0 -0.34 2 2
BCL2 0.005 0.066 -10000 0 -0.54 3 3
S1P1 pathway

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.008 0.061 -9999 0 -0.42 4 4
PDGFRB -0.003 0.093 -9999 0 -0.59 5 5
SPHK1 -0.021 0.079 -9999 0 -0.77 2 2
mol:S1P -0.027 0.08 -9999 0 -0.52 4 4
S1P1/S1P/Gi -0.049 0.17 -9999 0 -0.52 13 13
GNAO1 -0.017 0.13 -9999 0 -0.58 10 10
PDGFB-D/PDGFRB/PLCgamma1 -0.042 0.16 -9999 0 -0.48 13 13
PLCG1 -0.042 0.17 -9999 0 -0.5 12 12
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB -0.003 0.093 -9999 0 -0.59 5 5
GNAI2 0.011 0.005 -9999 0 -10000 0 0
GNAI3 0.011 0.005 -9999 0 -10000 0 0
GNAI1 -0.023 0.14 -9999 0 -0.63 11 11
mol:GDP 0 0 -9999 0 -10000 0 0
EDG1 0.007 0.052 -9999 0 -0.35 4 4
S1P1/S1P -0.034 0.077 -9999 0 -0.42 4 4
negative regulation of cAMP metabolic process -0.047 0.17 -9999 0 -0.5 13 13
MAPK3 -0.06 0.21 -9999 0 -0.56 24 24
calcium-dependent phospholipase C activity -0.002 0.003 -9999 0 -10000 0 0
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
KDR 0 0.082 -9999 0 -0.58 4 4
PLCB2 -0.001 0.091 -9999 0 -0.49 3 3
RAC1 0.013 0 -9999 0 -10000 0 0
RhoA/GTP -0.028 0.064 -9999 0 -0.38 3 3
receptor internalization -0.032 0.072 -9999 0 -0.39 4 4
PTGS2 -0.1 0.33 -9999 0 -0.95 23 23
Rac1/GTP -0.028 0.064 -9999 0 -0.36 4 4
RHOA 0.013 0 -9999 0 -10000 0 0
VEGFA 0.012 0.003 -9999 0 -10000 0 0
negative regulation of T cell proliferation -0.047 0.17 -9999 0 -0.5 13 13
GO:0007205 0 0 -9999 0 -10000 0 0
GNAZ -0.056 0.19 -9999 0 -0.59 23 23
MAPK1 -0.06 0.21 -9999 0 -0.55 25 25
S1P1/S1P/PDGFB-D/PDGFRB -0.009 0.11 -9999 0 -0.4 6 6
ABCC1 0.004 0.067 -9999 0 -0.55 3 3
FAS signaling pathway (CD95)

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 0.005 0.037 -10000 0 -0.24 1 1
RFC1 0.005 0.037 -10000 0 -0.24 1 1
PRKDC 0.005 0.037 -10000 0 -0.24 1 1
RIPK1 0.014 0.003 -10000 0 -10000 0 0
CASP7 -0.018 0.083 0.25 1 -0.75 2 3
FASLG/FAS/FADD/FAF1 -0.022 0.11 0.23 11 -0.32 14 25
MAP2K4 -0.02 0.14 -10000 0 -0.53 6 6
mol:ceramide -0.029 0.16 -10000 0 -0.46 14 14
GSN 0.005 0.037 -10000 0 -0.24 1 1
FASLG/FAS/FADD/FAF1/Caspase 8 -0.012 0.12 -10000 0 -0.39 13 13
FAS -0.004 0.098 -10000 0 -0.62 5 5
BID 0.004 0.048 0.3 3 -0.4 1 4
MAP3K1 -0.004 0.1 0.2 1 -0.6 3 4
MAP3K7 0.012 0.003 -10000 0 -10000 0 0
RB1 -0.002 0.064 -10000 0 -0.35 5 5
CFLAR 0.014 0.003 -10000 0 -10000 0 0
HGF/MET -0.049 0.16 -10000 0 -0.39 37 37
ARHGDIB -0.001 0.047 -10000 0 -0.31 2 2
FADD 0.009 0.039 -10000 0 -0.54 1 1
actin filament polymerization -0.005 0.037 0.24 1 -10000 0 1
NFKB1 -0.036 0.062 -10000 0 -0.32 1 1
MAPK8 -0.041 0.18 -10000 0 -0.49 16 16
DFFA 0.005 0.037 -10000 0 -0.24 1 1
DNA fragmentation during apoptosis 0.003 0.046 -10000 0 -0.31 2 2
FAS/FADD/MET -0.005 0.1 -10000 0 -0.38 14 14
CFLAR/RIP1 0.015 0.007 -10000 0 -10000 0 0
FAIM3 -0.001 0.093 -10000 0 -0.59 5 5
FAF1 0.012 0.005 -10000 0 -10000 0 0
PARP1 0.005 0.037 -10000 0 -0.24 1 1
DFFB 0.003 0.046 -10000 0 -0.31 2 2
CHUK -0.03 0.053 -10000 0 -10000 0 0
FASLG -0.064 0.2 -10000 0 -0.59 26 26
FAS/FADD 0.003 0.078 -10000 0 -0.44 6 6
HGF -0.038 0.17 -10000 0 -0.59 17 17
LMNA 0.005 0.034 -10000 0 -10000 0 0
CASP6 0.005 0.037 -10000 0 -0.24 1 1
CASP10 -0.004 0.098 -10000 0 -0.62 5 5
CASP3 0.006 0.044 0.22 6 -0.28 1 7
PTPN13 -0.03 0.16 -10000 0 -0.62 14 14
CASP8 0.006 0.064 0.34 5 -0.47 1 6
IL6 -0.098 0.3 -10000 0 -1 15 15
MET -0.012 0.12 -10000 0 -0.62 8 8
ICAD/CAD 0.003 0.043 -10000 0 -0.34 1 1
FASLG/FAS/FADD/FAF1/Caspase 10 -0.029 0.16 -10000 0 -0.46 14 14
activation of caspase activity by cytochrome c 0.004 0.048 0.3 3 -0.4 1 4
PAK2 0.005 0.038 -10000 0 -0.25 1 1
BCL2 0.005 0.066 -10000 0 -0.54 3 3
IL2 signaling events mediated by STAT5

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.011 0.038 -9999 0 -0.54 1 1
ELF1 -0.006 0.098 -9999 0 -0.37 12 12
CCNA2 0.013 0 -9999 0 -10000 0 0
PIK3CA 0.01 0.044 -9999 0 -0.62 1 1
JAK3 -0.002 0.095 -9999 0 -0.6 5 5
PIK3R1 -0.009 0.11 -9999 0 -0.57 8 8
JAK1 0.013 0 -9999 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.014 0.16 -9999 0 -0.59 10 10
SHC1 0.013 0 -9999 0 -10000 0 0
SP1 0 0.076 -9999 0 -0.35 5 5
IL2RA -0.026 0.21 -9999 0 -0.74 15 15
IL2RB -0.019 0.14 -9999 0 -0.6 11 11
SOS1 0.013 0 -9999 0 -10000 0 0
IL2RG -0.039 0.17 -9999 0 -0.58 18 18
G1/S transition of mitotic cell cycle -0.009 0.17 -9999 0 -0.6 12 12
PTPN11 0.013 0 -9999 0 -10000 0 0
CCND2 -0.013 0.16 -9999 0 -0.6 14 14
LCK -0.004 0.1 -9999 0 -0.59 6 6
GRB2 0.013 0 -9999 0 -10000 0 0
IL2 -0.002 0.066 -9999 0 -0.54 3 3
CDK6 -0.012 0.12 -9999 0 -0.62 8 8
CCND3 0.025 0.14 -9999 0 -0.56 7 7
Regulation of Telomerase

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.12 0.33 -9999 0 -1 18 18
RAD9A 0.01 0.038 -9999 0 -0.54 1 1
AP1 -0.024 0.13 -9999 0 -0.42 20 20
IFNAR2 0.012 0.006 -9999 0 -10000 0 0
AKT1 -0.024 0.09 -9999 0 -0.24 21 21
ER alpha/Oestrogen -0.063 0.16 -9999 0 -0.44 33 33
NFX1/SIN3/HDAC complex 0.033 0.035 -9999 0 -10000 0 0
EGF -0.082 0.21 -9999 0 -0.57 33 33
SMG5 0.013 0 -9999 0 -10000 0 0
SMG6 0.013 0 -9999 0 -10000 0 0
SP3/HDAC2 0.015 0.034 -9999 0 -0.45 1 1
TERT/c-Abl -0.13 0.29 -9999 0 -0.99 17 17
SAP18 0.012 0.003 -9999 0 -10000 0 0
MRN complex 0.024 0.028 -9999 0 -0.38 1 1
WT1 -0.095 0.23 -9999 0 -0.58 37 37
WRN 0.013 0 -9999 0 -10000 0 0
SP1 0.012 0.009 -9999 0 -10000 0 0
SP3 0.009 0.044 -9999 0 -0.62 1 1
TERF2IP 0.013 0 -9999 0 -10000 0 0
Telomerase/Nucleolin -0.12 0.25 -9999 0 -0.94 14 14
Mad/Max 0.013 0.044 -9999 0 -0.42 2 2
TERT -0.13 0.35 -9999 0 -1.2 16 16
CCND1 -0.13 0.34 -9999 0 -1 20 20
MAX 0.012 0.005 -9999 0 -10000 0 0
RBBP7 0.009 0.038 -9999 0 -0.54 1 1
RBBP4 0 0.088 -9999 0 -0.62 4 4
TERF2 0.012 0 -9999 0 -10000 0 0
PTGES3 0.013 0 -9999 0 -10000 0 0
SIN3A 0.012 0.003 -9999 0 -10000 0 0
Telomerase/911 0.024 0.037 -9999 0 -10000 0 0
CDKN1B -0.065 0.18 -9999 0 -0.63 4 4
RAD1 0.013 0 -9999 0 -10000 0 0
XRCC5 0.013 0 -9999 0 -10000 0 0
XRCC6 0.013 0 -9999 0 -10000 0 0
SAP30 0.012 0.003 -9999 0 -10000 0 0
TRF2/PARP2 0 0 -9999 0 -10000 0 0
UBE3A 0.012 0.005 -9999 0 -10000 0 0
JUN 0.008 0.044 -9999 0 -0.62 1 1
E6 -0.001 0.004 -9999 0 -10000 0 0
HPV-16 E6/E6AP 0.009 0.006 -9999 0 -10000 0 0
FOS -0.042 0.17 -9999 0 -0.57 19 19
IFN-gamma/IRF1 -0.089 0.21 -9999 0 -0.44 51 51
PARP2 0.013 0 -9999 0 -10000 0 0
BLM 0.013 0 -9999 0 -10000 0 0
Telomerase 0.017 0.062 -9999 0 -0.32 1 1
IRF1 0 0.097 -9999 0 -0.62 5 5
ESR1 -0.085 0.22 -9999 0 -0.59 33 33
KU/TER 0.019 0 -9999 0 -10000 0 0
ATM/TRF2 0.02 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.038 0.037 -9999 0 -10000 0 0
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.037 0.038 -9999 0 -10000 0 0
HDAC1 0.012 0.003 -9999 0 -10000 0 0
HDAC2 0.012 0.009 -9999 0 -10000 0 0
ATM 0 0 -9999 0 -10000 0 0
SMAD3 0.009 0.08 -9999 0 -0.45 6 6
ABL1 0.01 0.044 -9999 0 -0.62 1 1
MXD1 0.006 0.058 -9999 0 -0.58 2 2
MRE11A 0.013 0 -9999 0 -10000 0 0
HUS1 0.013 0 -9999 0 -10000 0 0
RPS6KB1 0.013 0 -9999 0 -10000 0 0
TERT/NF kappa B1/14-3-3 -0.13 0.28 -9999 0 -1 16 16
NR2F2 0 0.094 -9999 0 -0.59 5 5
MAPK3 0.008 0.049 -9999 0 -0.39 3 3
MAPK1 0.008 0.049 -9999 0 -0.39 3 3
TGFB1/TGF beta receptor Type II -0.002 0.097 -9999 0 -0.62 5 5
NFKB1 0.01 0.038 -9999 0 -0.54 1 1
HNRNPC 0.013 0 -9999 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0 0 -9999 0 -10000 0 0
NBN 0.01 0.044 -9999 0 -0.62 1 1
EGFR -0.034 0.16 -9999 0 -0.62 15 15
mol:Oestrogen -0.001 0.003 -9999 0 -10000 0 0
EGF/EGFR -0.086 0.19 -9999 0 -0.43 47 47
MYC -0.056 0.2 -9999 0 -0.62 22 22
IL2 -0.004 0.067 -9999 0 -0.55 3 3
KU 0.019 0 -9999 0 -10000 0 0
RAD50 0.013 0 -9999 0 -10000 0 0
HSP90AA1 0.013 0 -9999 0 -10000 0 0
TGFB1 -0.002 0.098 -9999 0 -0.62 5 5
TRF2/BLM 0 0 -9999 0 -10000 0 0
FRAP1 0 0 -9999 0 -10000 0 0
KU/TERT -0.1 0.3 -9999 0 -1 15 15
SP1/HDAC2 0.019 0.015 -9999 0 -10000 0 0
PINX1 0.013 0 -9999 0 -10000 0 0
Telomerase/EST1A -0.12 0.25 -9999 0 -0.91 15 15
Smad3/Myc -0.028 0.16 -9999 0 -0.44 24 24
911 complex 0.024 0.024 -9999 0 -0.32 1 1
IFNG -0.13 0.25 -9999 0 -0.58 49 49
Telomerase/PinX1 -0.12 0.25 -9999 0 -0.94 14 14
Telomerase/AKT1/mTOR/p70S6K -0.004 0.076 -9999 0 -10000 0 0
SIN3B 0.012 0.003 -9999 0 -10000 0 0
YWHAE 0.013 0 -9999 0 -10000 0 0
Telomerase/EST1B -0.12 0.25 -9999 0 -0.94 14 14
response to DNA damage stimulus 0.003 0 -9999 0 -10000 0 0
MRN complex/TRF2/Rap1 -0.002 0.021 -9999 0 -10000 0 0
TRF2/WRN 0 0 -9999 0 -10000 0 0
Telomerase/hnRNP C1/C2 -0.12 0.25 -9999 0 -0.94 14 14
E2F1 0.012 0.006 -9999 0 -10000 0 0
ZNFX1 0.012 0.003 -9999 0 -10000 0 0
PIF1 0.01 0.044 -9999 0 -0.62 1 1
NCL 0.013 0 -9999 0 -10000 0 0
DKC1 0.013 0 -9999 0 -10000 0 0
telomeric DNA binding 0 0 -9999 0 -10000 0 0
S1P3 pathway

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.002 0.093 -9999 0 -0.59 5 5
mol:S1P 0.001 0.002 -9999 0 -10000 0 0
S1P1/S1P/Gi -0.022 0.12 -9999 0 -0.29 25 25
GNAO1 -0.015 0.13 -9999 0 -0.58 10 10
S1P/S1P3/G12/G13 0.006 0.085 -9999 0 -0.34 12 12
AKT1 -0.001 0.085 -9999 0 -0.53 3 3
AKT3 0.002 0.14 -9999 0 -0.76 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB -0.002 0.093 -9999 0 -0.59 5 5
GNAI2 0.014 0.002 -9999 0 -10000 0 0
GNAI3 0.014 0.002 -9999 0 -10000 0 0
GNAI1 -0.02 0.14 -9999 0 -0.62 11 11
mol:GDP 0 0 -9999 0 -10000 0 0
S1PR3 -0.022 0.14 -9999 0 -0.6 12 12
S1PR2 0.013 0 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.023 0.13 -9999 0 -0.45 9 9
MAPK3 -0.015 0.13 -9999 0 -0.47 7 7
MAPK1 -0.015 0.13 -9999 0 -0.47 7 7
JAK2 -0.025 0.14 -9999 0 -0.44 13 13
CXCR4 -0.038 0.16 -9999 0 -0.48 16 16
FLT1 0.007 0.071 -9999 0 -0.57 3 3
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
SRC -0.015 0.13 -9999 0 -0.47 7 7
S1P/S1P3/Gi -0.023 0.14 -9999 0 -0.46 9 9
RAC1 0.013 0 -9999 0 -10000 0 0
RhoA/GTP -0.016 0.12 -9999 0 -0.46 7 7
VEGFA 0.015 0.002 -9999 0 -10000 0 0
S1P/S1P2/Gi -0.011 0.11 -9999 0 -0.46 3 3
VEGFR1 homodimer/VEGFA homodimer 0.02 0.053 -9999 0 -0.41 3 3
RHOA 0.013 0 -9999 0 -10000 0 0
S1P/S1P3/Gq -0.05 0.15 -9999 0 -0.33 37 37
GNAQ 0.01 0.044 -9999 0 -0.62 1 1
GNAZ -0.053 0.19 -9999 0 -0.59 23 23
G12/G13 0.019 0 -9999 0 -10000 0 0
GNA14 -0.063 0.2 -9999 0 -0.56 27 27
GNA15 -0.039 0.17 -9999 0 -0.62 17 17
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
GNA11 -0.009 0.12 -9999 0 -0.62 7 7
Rac1/GTP -0.016 0.12 -9999 0 -0.46 7 7
ErbB2/ErbB3 signaling events

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 0.017 0.005 -10000 0 -10000 0 0
RAS family/GTP -0.013 0.1 -10000 0 -0.38 2 2
NFATC4 -0.018 0.11 -10000 0 -0.36 3 3
ERBB2IP 0.007 0.062 -10000 0 -0.62 2 2
HSP90 (dimer) 0.013 0 -10000 0 -10000 0 0
mammary gland morphogenesis -0.035 0.13 -10000 0 -0.49 3 3
JUN 0.014 0.075 -10000 0 -0.31 3 3
HRAS 0.013 0.001 -10000 0 -10000 0 0
DOCK7 -0.028 0.12 -10000 0 -0.46 3 3
ErbB2/ErbB3/neuregulin 1 beta/SHC -0.056 0.15 0.25 1 -0.36 27 28
AKT1 0.01 0.003 -10000 0 -10000 0 0
BAD 0.016 0.024 -10000 0 -0.32 1 1
MAPK10 -0.027 0.1 -10000 0 -0.3 9 9
mol:GTP 0 0.002 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta -0.036 0.14 -10000 0 -0.54 3 3
RAF1 -0.002 0.1 -10000 0 -0.36 2 2
ErbB2/ErbB3/neuregulin 2 -0.034 0.12 0.24 2 -0.32 28 30
STAT3 0.002 0.004 -10000 0 -10000 0 0
cell migration -0.011 0.086 -10000 0 -0.24 10 10
mol:PI-3-4-5-P3 -0.001 0.002 -10000 0 -10000 0 0
cell proliferation -0.032 0.2 -10000 0 -0.53 19 19
FOS -0.021 0.16 -10000 0 -0.4 18 18
NRAS 0.013 0.001 -10000 0 -10000 0 0
mol:Ca2+ -0.035 0.13 -10000 0 -0.49 3 3
MAPK3 -0.021 0.16 -10000 0 -0.43 17 17
MAPK1 -0.021 0.16 -10000 0 -0.43 17 17
JAK2 -0.031 0.13 -10000 0 -0.46 3 3
NF2 -0.002 0.005 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.032 0.12 -10000 0 -0.3 27 27
NRG1 -0.12 0.25 -10000 0 -0.59 44 44
GRB2/SOS1 0.019 0.001 -10000 0 -10000 0 0
MAPK8 -0.031 0.13 -10000 0 -0.33 14 14
MAPK9 0.001 0.071 -10000 0 -0.22 3 3
ERBB2 -0.008 0.079 0.4 2 -0.4 6 8
ERBB3 0.009 0.044 -10000 0 -0.63 1 1
SHC1 0.012 0.001 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
apoptosis 0.001 0.013 -10000 0 -10000 0 0
STAT3 (dimer) 0.017 0.006 -10000 0 -10000 0 0
RNF41 0.022 0.008 -10000 0 -10000 0 0
FRAP1 0.009 0.003 -10000 0 -10000 0 0
RAC1-CDC42/GTP -0.04 0.077 -10000 0 -0.32 3 3
ErbB2/ErbB2/HSP90 (dimer) -0.007 0.062 0.27 2 -0.33 6 8
CHRNA1 -0.035 0.2 -10000 0 -0.56 18 18
myelination -0.013 0.11 -10000 0 -0.36 3 3
PPP3CB -0.025 0.12 -10000 0 -0.43 3 3
KRAS 0.01 0.038 -10000 0 -0.54 1 1
RAC1-CDC42/GDP -0.015 0.1 -10000 0 -0.36 3 3
NRG2 -0.05 0.18 -10000 0 -0.56 22 22
mol:GDP -0.031 0.12 -10000 0 -0.3 27 27
SOS1 0.013 0.001 -10000 0 -10000 0 0
MAP2K2 0.003 0.11 -10000 0 -0.34 3 3
SRC 0.013 0 -10000 0 -10000 0 0
mol:cAMP -0.001 0.002 -10000 0 -10000 0 0
PTPN11 -0.027 0.12 -10000 0 -0.46 3 3
MAP2K1 -0.026 0.16 -10000 0 -0.46 8 8
heart morphogenesis -0.035 0.13 -10000 0 -0.49 3 3
RAS family/GDP -0.013 0.1 -10000 0 -0.38 2 2
GRB2 0.013 0.001 -10000 0 -10000 0 0
PRKACA -0.004 0.008 -10000 0 -10000 0 0
CHRNE 0.011 0.03 -10000 0 -0.2 3 3
HSP90AA1 0.013 0 -10000 0 -10000 0 0
activation of caspase activity -0.01 0.003 -10000 0 -10000 0 0
nervous system development -0.035 0.13 -10000 0 -0.49 3 3
CDC42 0.013 0 -10000 0 -10000 0 0
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.013 0 -9999 0 -10000 0 0
VLDLR -0.015 0.13 -9999 0 -0.61 9 9
LRPAP1 0.013 0 -9999 0 -10000 0 0
NUDC 0.013 0 -9999 0 -10000 0 0
RELN/LRP8 -0.04 0.15 -9999 0 -0.37 34 34
CaM/Ca2+ 0.009 0 -9999 0 -10000 0 0
KATNA1 0.013 0 -9999 0 -10000 0 0
GO:0030286 0 0 -9999 0 -10000 0 0
ABL1 -0.03 0.14 -9999 0 -0.38 19 19
IQGAP1/CaM 0.019 0 -9999 0 -10000 0 0
DAB1 -0.015 0.11 -9999 0 -0.54 8 8
IQGAP1 0.013 0 -9999 0 -10000 0 0
PLA2G7 -0.024 0.15 -9999 0 -0.61 12 12
CALM1 0.013 0 -9999 0 -10000 0 0
DYNLT1 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
LRPAP1/LRP8 0.01 0.065 -9999 0 -0.46 4 4
UniProt:Q4QZ09 0 0 -9999 0 -10000 0 0
CLIP1 0.013 0 -9999 0 -10000 0 0
CDK5R1 0.001 0.085 -9999 0 -0.6 4 4
LIS1/Poliovirus Protein 3A 0.016 0 -9999 0 -10000 0 0
CDK5R2 -0.033 0.14 -9999 0 -0.54 15 15
mol:PP1 0 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1 -0.066 0.17 -9999 0 -0.38 44 44
YWHAE 0.013 0 -9999 0 -10000 0 0
NDEL1/14-3-3 E -0.013 0.14 -9999 0 -0.53 5 5
MAP1B -0.025 0.073 -9999 0 -0.32 6 6
RAC1 0 0 -9999 0 -10000 0 0
p35/CDK5 -0.018 0.14 -9999 0 -0.75 2 2
RELN -0.078 0.21 -9999 0 -0.58 31 31
PAFAH/LIS1 0.002 0.093 -9999 0 -0.37 12 12
LIS1/CLIP170 0.025 0 -9999 0 -10000 0 0
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.04 0.088 -9999 0 -0.53 2 2
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.02 0.11 -9999 0 -0.54 2 2
GO:0005869 0 0 -9999 0 -10000 0 0
NDEL1 -0.022 0.14 -9999 0 -0.55 6 6
LIS1/IQGAP1 0.025 0 -9999 0 -10000 0 0
RHOA 0 0 -9999 0 -10000 0 0
PAFAH1B1 0.022 0 -9999 0 -10000 0 0
PAFAH1B3 0.013 0 -9999 0 -10000 0 0
PAFAH1B2 0.01 0.044 -9999 0 -0.62 1 1
MAP1B/LIS1/Dynein heavy chain 0.006 0.052 -9999 0 -10000 0 0
NDEL1/Katanin 60/Dynein heavy chain -0.007 0.13 -9999 0 -0.51 5 5
LRP8 0 0.088 -9999 0 -0.62 4 4
NDEL1/Katanin 60 -0.013 0.14 -9999 0 -0.53 5 5
P39/CDK5 -0.036 0.15 -9999 0 -0.61 6 6
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.025 0 -9999 0 -10000 0 0
CDK5 -0.02 0.13 -9999 0 -0.35 19 19
PPP2R5D 0.013 0 -9999 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.022 0 -9999 0 -10000 0 0
CSNK2A1 0.013 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.042 0.15 -9999 0 -0.6 4 4
RELN/VLDLR -0.043 0.16 -9999 0 -0.4 24 24
CDC42 0 0 -9999 0 -10000 0 0
Ceramide signaling pathway

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.011 0.069 -10000 0 -0.43 5 5
MAP4K4 0.015 0.083 -10000 0 -0.55 1 1
BAG4 -0.006 0.11 -10000 0 -0.62 6 6
PKC zeta/ceramide -0.007 0.036 0.16 2 -10000 0 2
NFKBIA 0.013 0 -10000 0 -10000 0 0
BIRC3 -0.038 0.16 -10000 0 -0.56 18 18
BAX 0 0.019 -10000 0 -10000 0 0
RIPK1 0.013 0 -10000 0 -10000 0 0
AKT1 0.018 0.008 -10000 0 -10000 0 0
BAD -0.009 0.042 0.17 2 -0.29 1 3
SMPD1 0.006 0.06 -10000 0 -0.21 8 8
RB1 -0.015 0.059 0.16 3 -0.35 4 7
FADD/Caspase 8 0.022 0.089 -10000 0 -0.46 3 3
MAP2K4 -0.004 0.046 -10000 0 -0.32 2 2
NSMAF 0.01 0.044 -10000 0 -0.62 1 1
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.004 0.045 -10000 0 -0.29 2 2
EGF -0.081 0.21 -10000 0 -0.57 33 33
mol:ceramide -0.017 0.039 0.17 3 -10000 0 3
MADD 0.013 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid 0.011 0.069 -10000 0 -0.43 5 5
ASAH1 0.013 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.015 0.059 0.16 3 -0.34 4 7
cell proliferation -0.043 0.11 -10000 0 -0.27 32 32
BID 0.013 0.058 -10000 0 -0.36 1 1
MAP3K1 -0.01 0.044 0.16 3 -0.35 1 4
EIF2A 0.006 0.033 -10000 0 -10000 0 0
TRADD 0.013 0 -10000 0 -10000 0 0
CRADD 0.013 0 -10000 0 -10000 0 0
MAPK3 0.007 0.042 -10000 0 -0.26 2 2
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 0.007 0.042 -10000 0 -0.3 1 1
Cathepsin D/ceramide -0.007 0.036 0.16 2 -10000 0 2
FADD 0.014 0.087 -10000 0 -0.46 2 2
KSR1 -0.011 0.047 0.17 2 -0.31 2 4
MAPK8 -0.009 0.071 0.17 2 -0.28 9 11
PRKRA -0.008 0.037 0.17 2 -10000 0 2
PDGFA -0.002 0.093 -10000 0 -0.59 5 5
TRAF2 0.013 0 -10000 0 -10000 0 0
IGF1 -0.12 0.25 -10000 0 -0.59 44 44
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.017 0.039 0.17 3 -10000 0 3
CTSD 0.013 0 -10000 0 -10000 0 0
regulation of nitric oxide biosynthetic process 0.017 0.028 -10000 0 -0.38 1 1
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.044 0.12 -10000 0 -0.29 32 32
PRKCD 0.013 0 -10000 0 -10000 0 0
PRKCZ 0.013 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine 0.011 0.069 -10000 0 -0.43 5 5
RelA/NF kappa B1 0.017 0.028 -10000 0 -0.38 1 1
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.013 0 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.008 0.087 -10000 0 -0.58 1 1
TNFR1A/BAG4/TNF-alpha -0.02 0.12 -10000 0 -0.35 25 25
mol:Sphingosine-1-phosphate 0.011 0.069 -10000 0 -0.43 5 5
MAP2K1 0.003 0.043 -10000 0 -0.3 1 1
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.013 0 -10000 0 -10000 0 0
CYCS -0.002 0.029 -10000 0 -10000 0 0
TNFRSF1A 0.013 0 -10000 0 -10000 0 0
NFKB1 0.01 0.038 -10000 0 -0.54 1 1
TNFR1A/BAG4 0.005 0.08 -10000 0 -0.46 6 6
EIF2AK2 -0.001 0.035 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/FAN -0.01 0.11 -10000 0 -0.34 20 20
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.02 0.068 -10000 0 -0.65 1 1
MAP2K2 0.003 0.043 -10000 0 -0.27 2 2
SMPD3 -0.009 0.1 -10000 0 -0.33 10 10
TNF -0.041 0.17 -10000 0 -0.57 19 19
PKC zeta/PAR4 0.019 0 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE 0.02 0.078 0.2 29 -10000 0 29
NF kappa B1/RelA/I kappa B alpha 0.036 0.021 -10000 0 -10000 0 0
AIFM1 -0.002 0.029 -10000 0 -10000 0 0
BCL2 0.005 0.066 -10000 0 -0.54 3 3
Paxillin-independent events mediated by a4b1 and a4b7

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels