Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	128.0	7732.0	60.0	-0.673	0.014	1000.0	-1000.0	-0.13	-1000.0
Ephrin A  reverse signaling	124.0	871.0	7.0	-0.146	-0.0	1000.0	-1000.0	-0.028	-1000.0
FOXM1 transcription factor network	97.0	4957.0	51.0	-0.41	0.025	1000.0	-1000.0	-0.164	-1000.0
TCGA08_retinoblastoma	93.0	747.0	8.0	-0.098	0.075	1000.0	-1000.0	-0.019	-1000.0
Aurora B signaling	86.0	5782.0	67.0	-0.337	0.014	1000.0	-1000.0	-0.067	-1000.0
IL12-mediated signaling events	83.0	7305.0	87.0	-0.561	0.121	1000.0	-1000.0	-0.123	-1000.0
E-cadherin signaling events	79.0	398.0	5.0	-0.123	0.014	1000.0	-1000.0	-0.042	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	78.0	5331.0	68.0	-0.481	0.23	1000.0	-1000.0	-0.112	-1000.0
Effects of Botulinum toxin	77.0	2022.0	26.0	-0.199	0.014	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by the Hedgehog family	73.0	3819.0	52.0	-0.189	0.152	1000.0	-1000.0	-0.059	-1000.0
TCR signaling in naïve CD8+ T cells	70.0	6532.0	93.0	-0.212	0.068	1000.0	-1000.0	-0.071	-1000.0
Syndecan-1-mediated signaling events	66.0	2266.0	34.0	-0.231	0.014	1000.0	-1000.0	-0.057	-1000.0
IL4-mediated signaling events	62.0	5680.0	91.0	-0.61	0.436	1000.0	-1000.0	-0.137	-1000.0
Syndecan-4-mediated signaling events	57.0	3820.0	67.0	-0.178	0.037	1000.0	-1000.0	-0.091	-1000.0
Glypican 2 network	56.0	224.0	4.0	-0.059	-0.016	1000.0	-1000.0	-0.041	-1000.0
Signaling events regulated by Ret tyrosine kinase	55.0	4511.0	82.0	-0.175	0.014	1000.0	-1000.0	-0.077	-1000.0
Thromboxane A2 receptor signaling	54.0	5675.0	105.0	-0.211	0.057	1000.0	-1000.0	-0.067	-1000.0
Reelin signaling pathway	54.0	3030.0	56.0	-0.28	0.014	1000.0	-1000.0	-0.072	-1000.0
Aurora C signaling	53.0	372.0	7.0	-0.158	-0.0	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	53.0	4396.0	82.0	-0.23	0.014	1000.0	-1000.0	-0.07	-1000.0
a4b1 and a4b7 Integrin signaling	52.0	260.0	5.0	-0.076	-0.033	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-alpha and p38-beta	51.0	2277.0	44.0	-0.148	0.014	1000.0	-1000.0	-0.052	-1000.0
FOXA2 and FOXA3 transcription factor networks	50.0	2300.0	46.0	-0.268	0.02	1000.0	-1000.0	-0.05	-1000.0
Endothelins	49.0	4741.0	96.0	-0.189	0.014	1000.0	-1000.0	-0.078	-1000.0
Caspase cascade in apoptosis	48.0	3562.0	74.0	-0.187	0.043	1000.0	-1000.0	-0.052	-1000.0
Visual signal transduction: Cones	47.0	1805.0	38.0	-0.153	0.017	1000.0	-1000.0	-0.059	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	45.0	3835.0	85.0	-0.147	0.014	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	45.0	774.0	17.0	-0.126	0.023	1000.0	-1000.0	-0.037	-1000.0
HIF-1-alpha transcription factor network	43.0	3310.0	76.0	-0.189	0.086	1000.0	-1000.0	-0.093	-1000.0
Glypican 1 network	43.0	2108.0	48.0	-0.166	0.03	1000.0	-1000.0	-0.05	-1000.0
Calcium signaling in the CD4+ TCR pathway	43.0	1335.0	31.0	-0.178	0.014	1000.0	-1000.0	-0.074	-1000.0
Visual signal transduction: Rods	43.0	2266.0	52.0	-0.203	0.014	1000.0	-1000.0	-0.079	-1000.0
Arf6 signaling events	42.0	2646.0	62.0	-0.198	0.014	1000.0	-1000.0	-0.054	-1000.0
PDGFR-alpha signaling pathway	42.0	1880.0	44.0	-0.171	0.027	1000.0	-1000.0	-0.052	-1000.0
p75(NTR)-mediated signaling	41.0	5161.0	125.0	-0.159	0.014	1000.0	-1000.0	-0.089	-1000.0
PLK1 signaling events	39.0	3353.0	85.0	-0.17	0.041	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	39.0	4522.0	114.0	-0.429	0.234	1000.0	-1000.0	-0.061	-1000.0
PLK2 and PLK4 events	38.0	115.0	3.0	-0.018	-0.013	1000.0	-1000.0	-0.016	-1000.0
Osteopontin-mediated events	38.0	1465.0	38.0	-0.133	0.016	1000.0	-1000.0	-0.09	-1000.0
IL1-mediated signaling events	38.0	2356.0	62.0	-0.188	0.064	1000.0	-1000.0	-0.089	-1000.0
Nongenotropic Androgen signaling	37.0	1969.0	52.0	-0.108	0.037	1000.0	-1000.0	-0.051	-1000.0
LPA receptor mediated events	37.0	3850.0	102.0	-0.184	0.019	1000.0	-1000.0	-0.075	-1000.0
BCR signaling pathway	37.0	3687.0	99.0	-0.169	0.03	1000.0	-1000.0	-0.083	-1000.0
EGFR-dependent Endothelin signaling events	37.0	783.0	21.0	-0.114	0.014	1000.0	-1000.0	-0.06	-1000.0
Wnt signaling	36.0	254.0	7.0	-0.034	-0.013	1000.0	-1000.0	-0.017	-1000.0
TCGA08_p53	34.0	242.0	7.0	-0.074	0.049	1000.0	-1000.0	-0.015	-1000.0
IL6-mediated signaling events	33.0	2534.0	75.0	-0.149	0.064	1000.0	-1000.0	-0.074	-1000.0
BMP receptor signaling	32.0	2662.0	81.0	-0.174	0.05	1000.0	-1000.0	-0.085	-1000.0
Fc-epsilon receptor I signaling in mast cells	32.0	3129.0	97.0	-0.187	0.04	1000.0	-1000.0	-0.08	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	32.0	1684.0	52.0	-0.19	0.027	1000.0	-1000.0	-0.049	-1000.0
Angiopoietin receptor Tie2-mediated signaling	32.0	2868.0	88.0	-0.183	0.019	1000.0	-1000.0	-0.11	-1000.0
Coregulation of Androgen receptor activity	31.0	2358.0	76.0	-0.139	0.027	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	31.0	1181.0	37.0	-0.134	0.014	1000.0	-1000.0	-0.053	-1000.0
ErbB2/ErbB3 signaling events	30.0	1989.0	65.0	-0.167	0.023	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	30.0	1754.0	58.0	-0.187	0.016	1000.0	-1000.0	-0.072	-1000.0
Rapid glucocorticoid signaling	30.0	614.0	20.0	-0.174	0.014	1000.0	-1000.0	-0.038	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	29.0	3545.0	120.0	-0.211	0.13	1000.0	-1000.0	-0.07	-1000.0
Syndecan-2-mediated signaling events	28.0	1991.0	69.0	-0.158	0.034	1000.0	-1000.0	-0.05	-1000.0
FAS signaling pathway (CD95)	28.0	1325.0	47.0	-0.148	0.016	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	27.0	324.0	12.0	-0.052	0.014	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	27.0	3703.0	136.0	-0.223	0.219	1000.0	-1000.0	-0.066	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	27.0	1482.0	54.0	-0.159	0.029	1000.0	-1000.0	-0.087	-1000.0
Presenilin action in Notch and Wnt signaling	27.0	1676.0	61.0	-0.275	0.03	1000.0	-1000.0	-0.069	-1000.0
IL2 signaling events mediated by STAT5	27.0	607.0	22.0	-0.093	0.019	1000.0	-1000.0	-0.04	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	26.0	885.0	34.0	-0.062	0.014	1000.0	-1000.0	-0.063	-1000.0
Noncanonical Wnt signaling pathway	26.0	683.0	26.0	-0.113	0.014	1000.0	-1000.0	-0.05	-1000.0
JNK signaling in the CD4+ TCR pathway	25.0	427.0	17.0	-0.071	0.014	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by HDAC Class III	25.0	1025.0	40.0	-0.122	0.103	1000.0	-1000.0	-0.042	-1000.0
Syndecan-3-mediated signaling events	25.0	903.0	35.0	-0.158	0.014	1000.0	-1000.0	-0.055	-1000.0
Canonical Wnt signaling pathway	24.0	1256.0	51.0	-0.275	0.096	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in the nascent adherens junction	24.0	1848.0	76.0	-0.122	0.014	1000.0	-1000.0	-0.076	-1000.0
Cellular roles of Anthrax toxin	23.0	932.0	39.0	-0.158	0.019	1000.0	-1000.0	-0.026	-1000.0
IL2 signaling events mediated by PI3K	23.0	1375.0	58.0	-0.093	0.032	1000.0	-1000.0	-0.074	-1000.0
IL27-mediated signaling events	23.0	1201.0	51.0	-0.16	0.019	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by PTP1B	22.0	1722.0	76.0	-0.141	0.02	1000.0	-1000.0	-0.074	-1000.0
Ceramide signaling pathway	22.0	1716.0	76.0	-0.153	0.022	1000.0	-1000.0	-0.055	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	21.0	1556.0	74.0	-0.165	0.064	1000.0	-1000.0	-0.085	-1000.0
ErbB4 signaling events	20.0	1442.0	69.0	-0.15	0.041	1000.0	-1000.0	-0.076	-1000.0
TCGA08_rtk_signaling	20.0	540.0	26.0	-0.146	0.028	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1634.0	78.0	-0.062	0.04	1000.0	-1000.0	-0.06	-1000.0
S1P1 pathway	19.0	707.0	36.0	-0.102	0.014	1000.0	-1000.0	-0.054	-1000.0
Sphingosine 1-phosphate (S1P) pathway	18.0	507.0	28.0	-0.131	0.024	1000.0	-1000.0	-0.039	-1000.0
S1P5 pathway	18.0	318.0	17.0	-0.131	0.052	1000.0	-1000.0	-0.039	-1000.0
Ephrin B reverse signaling	18.0	911.0	48.0	-0.1	0.076	1000.0	-1000.0	-0.063	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	18.0	1508.0	83.0	-0.19	0.053	1000.0	-1000.0	-0.068	-1000.0
Aurora A signaling	17.0	1068.0	60.0	-0.135	0.032	1000.0	-1000.0	-0.059	-1000.0
Integrins in angiogenesis	17.0	1465.0	84.0	-0.094	0.014	1000.0	-1000.0	-0.088	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	17.0	785.0	45.0	-0.153	0.031	1000.0	-1000.0	-0.083	-1000.0
Insulin-mediated glucose transport	16.0	522.0	32.0	-0.11	0.034	1000.0	-1000.0	-0.054	-1000.0
TRAIL signaling pathway	16.0	795.0	48.0	-0.047	0.029	1000.0	-1000.0	-0.065	-1000.0
EPHB forward signaling	16.0	1380.0	85.0	-0.1	0.035	1000.0	-1000.0	-0.081	-1000.0
Regulation of Telomerase	16.0	1685.0	102.0	-0.138	0.045	1000.0	-1000.0	-0.092	-1000.0
E-cadherin signaling in keratinocytes	16.0	701.0	43.0	-0.122	0.026	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-gamma and p38-delta	15.0	236.0	15.0	-0.027	0.026	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	14.0	804.0	57.0	-0.052	0.029	1000.0	-1000.0	-0.061	-1000.0
Regulation of p38-alpha and p38-beta	14.0	788.0	54.0	-0.116	0.014	1000.0	-1000.0	-0.057	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1219.0	86.0	-0.056	0.033	1000.0	-1000.0	-0.077	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	14.0	466.0	33.0	-0.103	0.041	1000.0	-1000.0	-0.056	-1000.0
Regulation of Androgen receptor activity	14.0	987.0	70.0	-0.127	0.032	1000.0	-1000.0	-0.068	-1000.0
ceramide signaling pathway	13.0	676.0	49.0	-0.153	0.02	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	13.0	484.0	36.0	-0.134	0.03	1000.0	-1000.0	-0.069	-1000.0
S1P4 pathway	13.0	341.0	25.0	-0.131	0.03	1000.0	-1000.0	-0.051	-1000.0
EPO signaling pathway	12.0	680.0	55.0	-0.114	0.057	1000.0	-1000.0	-0.082	-1000.0
p38 MAPK signaling pathway	12.0	553.0	44.0	-0.071	0.02	1000.0	-1000.0	-0.063	-1000.0
Nectin adhesion pathway	11.0	726.0	63.0	-0.123	0.048	1000.0	-1000.0	-0.071	-1000.0
Canonical NF-kappaB pathway	10.0	404.0	39.0	-0.153	0.086	1000.0	-1000.0	-0.081	-1000.0
IFN-gamma pathway	10.0	717.0	68.0	-0.23	0.058	1000.0	-1000.0	-0.083	-1000.0
Class I PI3K signaling events	10.0	785.0	73.0	-0.106	0.03	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by PRL	10.0	351.0	34.0	-0.064	0.021	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	9.0	206.0	22.0	-0.018	0.033	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class I	9.0	1007.0	104.0	-0.153	0.058	1000.0	-1000.0	-0.057	-1000.0
Class IB PI3K non-lipid kinase events	9.0	27.0	3.0	-0.004	0.004	1000.0	-1000.0	-0.017	-1000.0
HIF-2-alpha transcription factor network	8.0	352.0	43.0	-0.097	0.098	1000.0	-1000.0	-0.076	-1000.0
Atypical NF-kappaB pathway	8.0	260.0	31.0	-0.081	0.029	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	8.0	1055.0	125.0	-0.073	0.075	1000.0	-1000.0	-0.096	-1000.0
Insulin Pathway	7.0	542.0	74.0	-0.181	0.038	1000.0	-1000.0	-0.082	-1000.0
VEGFR1 specific signals	7.0	419.0	56.0	-0.092	0.04	1000.0	-1000.0	-0.073	-1000.0
S1P3 pathway	7.0	330.0	42.0	-0.033	0.031	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class II	6.0	500.0	75.0	-0.174	0.038	1000.0	-1000.0	-0.057	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	434.0	65.0	-0.043	0.064	1000.0	-1000.0	-0.061	-1000.0
PDGFR-beta signaling pathway	6.0	617.0	97.0	-0.055	0.063	1000.0	-1000.0	-0.08	-1000.0
FoxO family signaling	5.0	350.0	64.0	-0.11	0.12	1000.0	-1000.0	-0.065	-1000.0
Arf6 trafficking events	5.0	366.0	71.0	-0.112	0.047	1000.0	-1000.0	-0.072	-1000.0
IGF1 pathway	5.0	311.0	57.0	-0.048	0.053	1000.0	-1000.0	-0.086	-1000.0
Arf6 downstream pathway	4.0	212.0	43.0	-0.027	0.028	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	335.0	68.0	-0.11	0.054	1000.0	-1000.0	-0.054	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	51.0	23.0	-0.014	0.05	1000.0	-1000.0	-0.061	-1000.0
Alternative NF-kappaB pathway	2.0	28.0	13.0	-0.005	0.014	1000.0	-1000.0	-0.052	-1000.0
mTOR signaling pathway	1.0	87.0	53.0	-0.005	0.036	1000.0	-1000.0	-0.056	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	20.0	27.0	-0.004	0.036	1000.0	-1000.0	-0.053	-1000.0
Arf1 pathway	0.0	25.0	54.0	-0.003	0.037	1000.0	-1000.0	-0.04	-1000.0
Total	4033	221000	7203	-19.6527588674	5.52073666802	131000	-131000	-8.22575340719	-131000