rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(1), HRAS(1), NGFR(1), NTRK1(4), SHC1(2), SOS1(6)	8403199	24	24	24	1	1	6	3	13	1	0	0.00904	0.00385	1.000
2	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(1), PDXP(1), PSAT1(1)	2946049	10	10	10	0	1	1	0	6	2	0	0.144	0.0160	1.000
3	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(4), EGFR(7), HGS(2), RAB5A(1)	7898260	19	19	18	0	3	1	5	5	5	0	0.0101	0.0219	1.000
4	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(5), STAT1(4)	5136758	16	16	16	2	1	0	1	10	4	0	0.398	0.0252	1.000
5	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(7), PIK3R1(2), RAC1(1), WASL(6)	7015144	21	20	21	2	0	4	1	13	3	0	0.116	0.0273	1.000
6	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(3), TYR(3)	5954630	15	15	15	1	1	2	5	5	2	0	0.0766	0.0325	1.000
7	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(2), GOT2(2), TYR(3)	2929848	9	9	9	1	0	0	3	2	4	0	0.444	0.0328	1.000
8	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(4), AKT1(2), ATM(15), CDKN1A(1), CSNK1A1(1), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1)	11769948	29	26	29	1	0	4	5	10	10	0	0.00936	0.0414	1.000
9	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(7), ERBB3(3), NRG1(4), UBE2D1(2)	6368227	20	20	19	3	2	1	4	8	5	0	0.241	0.0453	1.000
10	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(7), MAP3K1(4), MAPK14(1), NCOR2(4), RARA(4), THRA(2)	10677896	26	26	25	2	1	3	7	8	7	0	0.0341	0.0498	1.000
11	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(5), GLS(4), GOT1(2)	4816366	13	13	13	1	0	2	1	7	3	0	0.207	0.0514	1.000
12	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(1), GOT1(2), GOT2(2), LDHB(1), LDHC(1), MPST(2)	4180017	13	13	13	2	1	0	2	6	4	0	0.471	0.0584	1.000
13	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	2522169	9	9	9	2	0	1	3	2	3	0	0.523	0.0622	1.000
14	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NNMT(1), NNT(6), NT5M(2), QPRT(1)	8974205	20	20	20	1	0	3	3	12	2	0	0.0354	0.0850	1.000
15	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(2), HLA-DRA(1)	1276465	4	4	4	0	1	1	0	1	1	0	0.324	0.0863	1.000
16	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(4)	3264531	10	10	10	2	1	1	1	4	3	0	0.529	0.0996	1.000
17	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(4), GNB1(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1)	9330868	22	22	22	2	2	2	1	14	3	0	0.126	0.107	1.000
18	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(3), AASDHPPT(2), AASS(4), KARS(1)	4362596	10	10	10	1	0	2	0	3	5	0	0.418	0.111	1.000
19	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3E(2), CD3G(1), CD4(2)	2024848	6	5	6	0	1	2	1	2	0	0	0.121	0.121	1.000
20	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(4), KARS(1)	2965715	7	7	7	1	0	1	0	2	4	0	0.574	0.129	1.000
21	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	724975	3	2	3	0	0	1	1	1	0	0	0.376	0.150	1.000
22	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(2), MAPK3(1), POLR2A(6), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	7845704	19	18	19	2	4	2	2	9	2	0	0.0923	0.150	1.000
23	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(2), NDUFA13(2)	2543806	6	6	6	0	2	1	0	2	1	0	0.182	0.153	1.000
24	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1), TOB1(2), TOB2(3)	6625463	17	16	17	2	1	3	4	7	2	0	0.167	0.156	1.000
25	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2)	3715075	12	11	12	2	1	3	1	6	1	0	0.241	0.157	1.000
26	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1)	6208875	13	13	13	1	2	2	2	7	0	0	0.107	0.158	1.000
27	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(2)	1638319	4	4	4	1	0	0	2	0	2	0	0.685	0.169	1.000
28	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(6), NCOA3(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RARA(4)	12711401	27	27	27	2	2	1	7	16	1	0	0.0208	0.171	1.000
29	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), IDS(2), IDUA(1), LCT(2)	8830693	22	18	20	2	4	2	4	10	2	0	0.0329	0.175	1.000
30	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(2), HLA-DRA(1), IL4(1)	2269336	5	5	5	1	1	1	1	1	1	0	0.491	0.179	1.000
31	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(6)	5348304	11	11	11	1	0	0	4	6	1	0	0.206	0.191	1.000
32	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(3), MYC(1), SP3(1), WT1(3)	3721347	10	10	10	2	0	1	0	7	2	0	0.674	0.201	1.000
33	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD3E(2), CD3G(1), CD4(2), IL3(1), KITLG(2)	3881708	9	8	9	1	0	2	1	5	1	0	0.349	0.222	1.000
34	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(2), ECHS1(2), HADHA(1)	3351862	6	6	5	0	3	0	2	1	0	0	0.105	0.224	1.000
35	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), SPAM1(4)	12652402	34	27	32	4	6	5	5	15	3	0	0.0155	0.227	1.000
36	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), HBXIP(1), HRAS(1), PTK2B(2), SHC1(2), SOS1(6), SRC(2)	5343368	15	15	15	3	1	6	2	6	0	0	0.277	0.228	1.000
37	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	9796405	19	19	19	1	3	0	0	12	4	0	0.0483	0.245	1.000
38	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(4), PRODH(1)	3471066	7	7	7	0	0	1	2	3	1	0	0.179	0.252	1.000
39	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(2)	2752495	6	6	6	0	0	1	0	5	0	0	0.272	0.261	1.000
40	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAP2B(2)	8918662	21	21	21	3	2	1	2	11	5	0	0.363	0.274	1.000
41	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1)	6501222	12	12	12	1	1	1	1	5	4	0	0.250	0.277	1.000
42	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	450414	1	1	1	0	0	0	1	0	0	0	0.751	0.277	1.000
43	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), STX1A(1)	1996435	4	4	4	1	0	0	0	2	2	0	0.856	0.281	1.000
44	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(5), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(1), SRC(2)	12092696	33	31	32	5	1	6	4	16	6	0	0.124	0.302	1.000
45	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(1)	7386124	13	12	13	1	2	4	3	2	2	0	0.0801	0.302	1.000
46	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(1), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(3)	7260897	18	18	18	3	1	3	4	7	3	0	0.240	0.306	1.000
47	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH11(3)	2927708	6	6	6	0	1	0	1	4	0	0	0.234	0.306	1.000
48	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IL4(1), JUN(2), MAP3K1(4), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(1), TNFRSF9(1), TNFSF9(1)	12202915	23	22	23	2	0	3	1	13	6	0	0.170	0.319	1.000
49	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6)	13758110	34	29	34	3	2	5	2	22	3	0	0.0390	0.327	1.000
50	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6)	13758110	34	29	34	3	2	5	2	22	3	0	0.0390	0.327	1.000
51	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(2), AOC3(1), CES1(2)	3505264	10	9	10	2	0	2	2	6	0	0	0.360	0.338	1.000
52	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(2), LUM(1)	2235482	6	6	6	2	0	1	0	4	1	0	0.681	0.341	1.000
53	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PRF1(1)	5137727	11	9	11	1	1	3	2	4	1	0	0.141	0.353	1.000
54	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(3), AKT3(2), GRB2(1), ILK(1), MAPK3(1), PDK1(1), PTK2B(2), RBL2(2), SHC1(2), SOS1(6)	10618412	23	22	23	3	2	7	3	10	1	0	0.0690	0.354	1.000
55	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), GOT1(2), GOT2(2), PAH(3), YARS(1)	5167192	11	11	11	2	0	0	4	4	3	0	0.457	0.362	1.000
56	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(4)	7072431	19	17	19	3	1	0	1	13	4	0	0.445	0.362	1.000
57	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(1)	3042194	5	5	5	0	1	2	1	1	0	0	0.153	0.363	1.000
58	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(4), MMP9(1), RECK(1)	4647674	8	8	8	1	0	2	1	3	2	0	0.375	0.367	1.000
59	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(11), MAP2(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1), PRKCE(2)	11238170	24	23	24	3	4	1	0	15	4	0	0.232	0.373	1.000
60	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT1(1), GCNT2(4), ST8SIA1(2)	3625939	8	8	8	2	1	1	1	3	2	0	0.593	0.376	1.000
61	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	1069531	2	2	2	0	0	1	0	1	0	0	0.498	0.382	1.000
62	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(1), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(3)	7138474	17	17	17	3	1	3	3	7	3	0	0.287	0.384	1.000
63	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(2), CD3G(1), CD4(2), ITGAL(4), ITGB2(1), PTPRC(6)	6984514	17	15	17	3	2	3	2	9	1	0	0.253	0.391	1.000
64	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), RAC1(1), WASL(6)	5054098	11	11	11	2	0	3	0	8	0	0	0.439	0.403	1.000
65	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(3), TPI1(1)	2389282	6	6	6	4	0	0	1	1	4	0	0.993	0.404	1.000
66	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2)	3885215	10	10	10	2	0	1	0	8	1	0	0.676	0.411	1.000
67	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), MST1(1), MST1R(4)	3737496	6	6	5	1	0	0	4	1	1	0	0.523	0.419	1.000
68	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(2), SYT1(1)	7152685	12	12	12	0	1	1	1	7	2	0	0.0891	0.420	1.000
69	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), GNB1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	5851185	15	15	15	3	2	1	0	11	1	0	0.564	0.444	1.000
70	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(3), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(1), ULK3(3)	13185203	23	23	23	2	1	3	1	13	5	0	0.120	0.448	1.000
71	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), CD4(2), FYN(1), HLA-DRA(1), PTPRC(6)	5358108	13	11	13	2	0	2	1	8	2	0	0.424	0.453	1.000
72	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), UGP2(1), UXS1(1)	3135576	5	5	5	1	0	0	3	2	0	0	0.562	0.466	1.000
73	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1B(1), BMPR2(4)	3811083	7	6	7	0	0	0	1	4	2	0	0.162	0.466	1.000
74	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), UXS1(1)	2482167	4	4	4	1	0	0	2	2	0	0	0.701	0.475	1.000
75	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(4), HRAS(1), PAX3(1), PML(3), RARA(4), RB1(1), SIRT1(4), SP100(1), TNFRSF1A(1)	10885758	24	23	24	4	1	4	5	12	2	0	0.201	0.502	1.000
76	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ARPC1B(1), ARPC2(1), NCKAP1(1), NTRK1(4), RAC1(1), WASF2(1), WASF3(1), WASL(6)	9435096	17	17	17	2	0	3	1	12	1	0	0.229	0.510	1.000
77	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SEPHS1(1)	7505152	14	14	14	2	2	0	4	5	3	0	0.240	0.513	1.000
78	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(3), POLG(2), PRPS2(2), RRM1(2)	7707287	13	13	13	2	2	3	1	5	2	0	0.215	0.515	1.000
79	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(4), GLI3(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SHH(1), SMO(3)	9620228	22	21	22	4	4	1	2	13	2	0	0.291	0.533	1.000
80	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), HLA-DRA(1), IFNA1(2), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1)	7932143	14	14	14	2	0	5	1	7	1	0	0.172	0.535	1.000
81	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(6), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), TBXA2R(1)	6477318	17	17	17	4	1	2	4	7	3	0	0.473	0.536	1.000
82	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(2), CFTR(4), GNAS(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	7871603	20	20	20	4	2	2	0	13	3	0	0.602	0.539	1.000
83	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(3), PPP1R1B(1)	2194172	5	5	5	2	1	1	0	3	0	0	0.747	0.541	1.000
84	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), MARS(2), MARS2(3)	10707151	18	18	18	2	2	2	5	6	3	0	0.114	0.543	1.000
85	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(1), PON3(2), RDH11(3)	5499382	8	8	8	1	1	0	3	4	0	0	0.363	0.544	1.000
86	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(1), HLA-DRA(1), ITGAL(4), ITGB2(1), PTPRC(6)	9271803	20	19	20	3	2	1	1	12	4	0	0.339	0.549	1.000
87	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(2), HADHA(1), HADHB(2)	5239709	7	7	7	0	1	3	2	1	0	0	0.0751	0.554	1.000
88	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1)	5191321	8	7	8	0	1	1	4	2	0	0	0.0635	0.560	1.000
89	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), CREM(1), FHL5(2), GNAS(4), XPO1(6)	5753041	14	14	14	3	2	1	3	7	1	0	0.521	0.560	1.000
90	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PTPRC(6)	6594819	15	13	15	3	2	2	2	8	1	0	0.356	0.566	1.000
91	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD2(1), GGT1(2)	3484980	5	5	5	1	0	1	2	1	1	0	0.469	0.566	1.000
92	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), GBA(2), GBA3(2), MPO(4), TPO(3)	5150129	12	12	12	3	1	2	4	5	0	0	0.390	0.574	1.000
93	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(1), IL4(1), IL4R(2), IRS1(3), JAK1(4), JAK3(3), RPS6KB1(1), SHC1(2), STAT6(2)	8845567	21	21	21	4	3	3	2	9	4	0	0.271	0.585	1.000
94	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(1)	7829958	14	13	14	2	0	4	1	6	3	0	0.238	0.592	1.000
95	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(2)	3013227	4	4	4	0	1	0	1	0	2	0	0.467	0.593	1.000
96	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM7(1), GRM8(2)	11996305	25	25	25	4	4	5	1	13	2	0	0.125	0.596	1.000
97	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEP(1), LEPR(1), PRKAG1(1), PRKAG2(4)	9049850	12	12	12	1	0	3	3	3	3	0	0.0937	0.597	1.000
98	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(11)	5254489	12	9	12	2	1	5	2	4	0	0	0.249	0.598	1.000
99	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(1), AKR1B10(2), ALAS1(4), ALAS2(3), AOC2(2), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), GNMT(2), MAOA(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2), TARS2(3)	26493557	60	56	59	7	5	10	13	27	5	0	0.00239	0.600	1.000
100	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(2), HLA-DRA(1), IL4(1)	3130229	4	4	4	1	0	1	1	1	1	0	0.740	0.608	1.000
101	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), MARS(2), MARS2(3), MTAP(2)	12789093	20	20	20	2	2	2	6	7	3	0	0.0802	0.623	1.000
102	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI1(1), IDI2(2)	2721446	4	4	4	1	0	0	0	3	1	0	0.831	0.625	1.000
103	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), NFS1(2), TPK1(1)	4001753	5	5	5	0	2	0	0	3	0	0	0.310	0.628	1.000
104	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2)	3513076	6	6	5	2	1	0	0	3	2	0	0.896	0.638	1.000
105	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(1), ABCB4(1), ABCC1(2), ABCC3(7)	9082866	15	15	15	2	1	1	4	7	2	0	0.227	0.639	1.000
106	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(1), QPRT(1)	13268381	26	25	26	4	0	3	4	14	5	0	0.234	0.641	1.000
107	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(2), HADHA(1), SDHB(1)	4874713	6	6	6	0	1	2	2	1	0	0	0.110	0.643	1.000
108	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(2), IFNB1(2), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(2), JUN(2), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1), TRAF6(1)	18348027	34	33	33	4	4	8	0	15	7	0	0.0577	0.656	1.000
109	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(1), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(1), MPST(2), SULT1B1(1), SULT4A1(1)	7728778	18	18	18	4	1	0	2	9	6	0	0.707	0.656	1.000
110	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	953417	1	1	1	1	0	0	0	1	0	0	0.943	0.657	1.000
111	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NFKB1(1), NOX1(2), RELA(1), XDH(2)	6077631	8	8	8	1	0	2	2	4	0	0	0.251	0.657	1.000
112	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), EIF2S2(1), MAP3K14(1), NFKB1(1), RELA(1)	5723303	7	7	7	1	0	4	0	1	2	0	0.446	0.660	1.000
113	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1038575	1	1	1	0	0	0	0	1	0	0	0.838	0.660	1.000
114	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1)	6617914	11	11	11	2	0	3	2	3	3	0	0.443	0.662	1.000
115	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1)	8192549	16	16	16	3	0	1	2	8	5	0	0.536	0.668	1.000
116	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(2), IL3(1), KITLG(2), TGFB2(2), TGFB3(1)	5170275	9	9	9	2	0	1	1	6	1	0	0.663	0.674	1.000
117	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(1), RAB3A(1), RAB5A(1)	2650758	3	3	3	0	1	0	1	0	1	0	0.378	0.680	1.000
118	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(4), ARHGDIB(1), CASP1(1), CASP10(3), JUN(2), PRF1(1)	7740063	12	12	12	2	0	2	0	7	3	0	0.562	0.683	1.000
119	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(4), EGFR(7), GRB2(1), HRAS(1), MAPK3(1), PTPRB(3), RASA1(3), SHC1(2), SOS1(6), SPRY2(2), SPRY4(2), SRC(2)	15443263	35	32	34	5	4	11	5	10	5	0	0.0491	0.684	1.000
120	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2)	7709460	15	14	15	3	3	1	1	8	2	0	0.418	0.684	1.000
121	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	10184606	15	14	15	1	1	1	3	8	2	0	0.131	0.688	1.000
122	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), IL3(1)	1672187	2	2	2	0	0	0	0	1	1	0	0.825	0.690	1.000
123	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(2), GOT2(2), PAH(3), YARS(1)	5406809	9	9	9	2	0	0	3	3	3	0	0.568	0.696	1.000
124	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B4(1), HSD3B1(1)	5022413	6	6	6	1	1	0	3	2	0	0	0.435	0.698	1.000
125	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(4), C7(2)	7970191	12	12	12	2	1	2	1	6	2	0	0.330	0.700	1.000
126	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(5), COPA(4), GBF1(6), GPLD1(1), KDELR2(2), KDELR3(2)	10108847	21	20	21	4	0	1	4	11	4	1	0.455	0.705	1.000
127	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	3431600	11	11	11	4	0	1	3	4	3	0	0.757	0.706	1.000
128	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(6), RPE(1), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	10943629	21	17	19	3	1	5	4	5	6	0	0.171	0.706	1.000
129	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), FUT1(1), FUT6(1), GCNT2(4), ST3GAL6(1), ST8SIA1(2)	9346872	17	16	17	3	2	3	3	5	4	0	0.291	0.713	1.000
130	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(4), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3)	5009016	14	14	12	4	0	1	2	9	2	0	0.642	0.716	1.000
131	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), CHUK(1), GHR(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(1)	7390505	9	9	9	0	0	4	0	3	2	0	0.0607	0.718	1.000
132	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(2)	4389203	6	6	6	1	0	0	0	5	1	0	0.622	0.730	1.000
133	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), PER1(4)	5237843	6	6	6	1	0	0	2	3	0	1	0.422	0.736	1.000
134	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1)	2379318	2	2	2	1	0	0	1	0	1	0	0.893	0.747	1.000
135	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(1), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5), SYT1(1)	13786023	25	25	23	4	1	5	1	15	3	0	0.223	0.755	1.000
136	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), ARF3(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(2)	4563662	13	13	13	6	0	1	2	5	5	0	0.928	0.760	1.000
137	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	1401723	1	1	1	1	0	0	1	0	0	0	0.902	0.769	1.000
138	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1)	4223555	5	5	5	0	0	0	1	4	0	0	0.364	0.770	1.000
139	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDKN1A(1), NEK1(2), WEE1(1)	4601050	5	5	5	1	0	1	0	3	1	0	0.707	0.784	1.000
140	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CD28(1), CD4(2), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1)	12475000	18	17	18	2	3	2	2	10	1	0	0.0994	0.788	1.000
141	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(1)	8764661	12	11	12	2	3	1	3	5	0	0	0.205	0.789	1.000
142	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC2(2), AOC3(1), CES1(2), DDHD1(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	15496342	26	23	26	2	1	3	4	15	3	0	0.0494	0.794	1.000
143	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(2), HK1(4), PFKL(1), PGAM1(1), PGK1(2), TPI1(1)	5618781	14	12	14	4	2	2	2	4	4	0	0.551	0.799	1.000
144	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST5(1), NDST1(2), NDST2(2), NDST4(3)	12515265	16	16	16	1	2	3	5	6	0	0	0.0312	0.800	1.000
145	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(6), CDH1(2), CREBBP(4), EP300(6), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1)	15938463	25	25	25	3	1	3	7	13	1	0	0.0575	0.800	1.000
146	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(2), MAPK14(1), THBS1(6)	4457452	10	10	10	3	0	0	2	7	1	0	0.790	0.809	1.000
147	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), IDH1(2), MDH1(1), SDHB(1)	5550156	8	8	8	2	1	0	1	5	1	0	0.570	0.811	1.000
148	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(1), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1)	6247357	10	9	10	2	0	2	1	5	2	0	0.456	0.813	1.000
149	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1)	2048015	2	2	2	1	0	0	0	1	1	0	0.951	0.821	1.000
150	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(2)	15122744	26	25	26	3	3	2	7	10	4	0	0.0713	0.822	1.000
151	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2C1(5), NEU1(1)	9707266	17	16	17	3	2	2	2	10	1	0	0.305	0.828	1.000
152	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F5(4), F7(1), FGA(1), FGG(1), PROC(4), PROS1(4), TFPI(1)	10095035	19	19	19	4	0	2	1	11	5	0	0.573	0.829	1.000
153	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKG1(2), PRKG2(2)	19142752	33	31	33	4	4	5	3	18	3	0	0.0531	0.832	1.000
154	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(15), ATR(5), CDC25C(2), CHEK2(1)	9446744	23	20	23	4	0	2	3	10	8	0	0.487	0.837	1.000
155	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(1), CDC25C(2), MYT1(2), WEE1(1)	8602771	21	18	21	4	0	2	3	10	6	0	0.425	0.840	1.000
156	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1)	5427994	13	12	13	4	1	3	2	3	4	0	0.602	0.842	1.000
157	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1)	14511885	28	26	27	4	0	5	3	15	5	0	0.112	0.844	1.000
158	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1)	8180078	10	10	10	1	0	0	1	7	2	0	0.447	0.850	1.000
159	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	6086980	8	8	8	2	1	1	0	4	2	0	0.304	0.851	1.000
160	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(1), PIK3R1(2), RB1(1), RELA(1)	10865196	17	17	17	3	2	5	0	8	2	0	0.254	0.851	1.000
161	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1)	5188358	10	10	10	3	0	1	1	5	3	0	0.807	0.852	1.000
162	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(3), TRAF6(1)	9068511	12	12	12	2	0	3	0	6	3	0	0.500	0.853	1.000
163	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1)	8092237	15	14	15	3	0	4	3	4	4	0	0.252	0.853	1.000
164	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), GREB1(10), HSPB2(1), MTA1(1), MTA3(1)	6525181	15	14	14	4	0	1	2	11	1	0	0.654	0.856	1.000
165	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	1256994	1	1	1	1	0	0	0	1	0	0	0.940	0.857	1.000
166	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6518339	9	9	9	2	2	1	1	5	0	0	0.414	0.857	1.000
167	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), IDI1(1), LSS(2), PMVK(1), SC5DL(1)	6858053	8	8	8	1	0	0	1	6	1	0	0.517	0.857	1.000
168	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3)	6430629	15	15	15	4	1	0	2	7	5	0	0.754	0.857	1.000
169	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3)	6430629	15	15	15	4	1	0	2	7	5	0	0.754	0.857	1.000
170	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS2(1), ECHS1(2), EHHADH(2), ESCO1(2), ESCO2(1), FN3K(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1)	15997725	22	21	22	2	2	3	4	9	4	0	0.0835	0.861	1.000
171	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(1), MEF2D(1)	5073214	5	5	5	0	1	0	0	2	2	0	0.462	0.867	1.000
172	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(2), NAT1(1), NAT2(2), XDH(2)	4930345	10	10	10	3	1	1	2	5	1	0	0.592	0.868	1.000
173	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(2)	2390471	4	4	4	2	0	0	2	1	1	0	0.861	0.874	1.000
174	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5)	10216827	17	17	17	3	2	0	0	11	4	0	0.428	0.875	1.000
175	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(4), CDKN2A(3), E2F1(1), MYC(1), PIK3R1(2), POLR1A(2), POLR1B(2), POLR1C(3), RAC1(1), RB1(1)	10249825	20	20	19	4	1	6	0	10	3	0	0.295	0.877	1.000
176	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), HSPB2(1), MAP2K6(1), MAP3K1(4), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK14(1), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1)	22702665	44	42	44	6	4	3	2	27	8	0	0.103	0.880	1.000
177	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(1), FUT6(1), ST3GAL3(1)	2904083	4	4	4	2	2	0	0	0	2	0	0.905	0.881	1.000
178	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), CD86(1), GRB2(1), HLA-DRA(1), ITK(1), PIK3R1(2), PTPN11(1)	6397219	11	10	11	3	1	4	1	3	2	0	0.575	0.884	1.000
179	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1)	9112464	11	10	11	1	1	2	2	5	1	0	0.212	0.885	1.000
180	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	2114168	1	1	1	1	0	0	0	0	1	0	0.967	0.885	1.000
181	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5740192	6	6	6	0	0	0	1	5	0	0	0.303	0.886	1.000
182	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5740192	6	6	6	0	0	0	1	5	0	0	0.303	0.886	1.000
183	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP68(2), SRP72(2), SRP9(1)	4691704	7	7	7	2	0	2	1	4	0	0	0.635	0.895	1.000
184	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), PDHA1(1), PDHA2(1), SLC18A3(1)	4103632	4	4	4	1	0	0	0	2	2	0	0.868	0.899	1.000
185	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1)	5409612	10	9	10	3	1	2	1	2	4	0	0.675	0.904	1.000
186	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(1), RENBP(2)	17800239	30	28	30	4	5	3	5	13	4	0	0.0622	0.911	1.000
187	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2A(1), MEF2D(1), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(1)	12743303	14	14	14	1	2	1	1	7	3	0	0.172	0.912	1.000
188	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), JAK1(4), STAT1(4), STAT3(1)	7417728	12	12	12	3	1	0	0	7	4	0	0.769	0.912	1.000
189	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(1), IFNB1(2), JAK1(4), STAT1(4), STAT2(3), TYK2(3)	6655388	19	19	19	5	1	4	2	7	5	0	0.427	0.912	1.000
190	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(4), ITGAM(3), ITGB2(1), SELE(4)	6658595	13	13	13	4	1	4	3	3	2	0	0.583	0.914	1.000
191	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	1903259	1	1	1	0	0	0	0	1	0	0	0.855	0.915	1.000
192	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(1), NFATC2(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	6884313	19	19	19	5	4	0	1	13	1	0	0.468	0.918	1.000
193	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(1)	4324396	6	6	6	3	1	0	1	1	3	0	0.933	0.922	1.000
194	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), TOP2A(3), TOP2B(1)	6310068	5	5	5	0	2	1	0	2	0	0	0.278	0.924	1.000
195	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CSNK1A1(1), MAPT(1), PPP2CA(1)	5781880	5	5	5	0	0	0	1	1	3	0	0.368	0.927	1.000
196	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(3), EIF2B5(1), EIF2S2(1), EIF5(2)	7115245	9	9	9	2	1	1	2	3	2	0	0.563	0.929	1.000
197	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(6), AXIN1(2), BTRC(2), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(1)	18016701	28	27	27	4	2	3	5	16	2	0	0.0782	0.933	1.000
198	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT1(1), LCMT2(3), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1)	8602143	12	11	12	2	1	2	1	7	1	0	0.436	0.936	1.000
199	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(3)	6009360	10	10	10	3	0	3	0	4	3	0	0.725	0.938	1.000
200	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	ATM(15), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), PCNA(3), RB1(1)	10783238	26	22	26	5	1	4	4	9	8	0	0.359	0.938	1.000
201	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1)	1919062	1	1	1	1	0	0	0	1	0	0	0.937	0.938	1.000
202	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2)	10747686	18	18	18	4	2	5	1	8	2	0	0.345	0.940	1.000
203	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1)	12025433	19	17	19	3	2	2	3	11	1	0	0.223	0.945	1.000
204	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1)	5980500	12	12	12	4	0	5	1	6	0	0	0.533	0.947	1.000
205	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNE1(2), CDK2(2), CDK4(1), CDKN2A(3), E2F1(1), PRB1(2)	5508148	14	13	14	6	1	2	2	5	4	0	0.849	0.949	1.000
206	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(1), RB1(1)	5264017	10	9	10	4	1	2	1	2	4	0	0.852	0.951	1.000
207	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), EIF4E(1), FBL(1), GPT(1), LDHB(1), LDHC(1), MAPK14(1), NCL(3)	5538188	15	15	15	6	0	0	4	7	4	0	0.938	0.953	1.000
208	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2)	8506571	15	14	15	4	1	3	4	5	2	0	0.449	0.956	1.000
209	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), CHST12(1), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(2)	5320563	11	11	11	4	2	0	4	1	4	0	0.827	0.957	1.000
210	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(4), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), SYT1(1)	16701000	25	25	25	4	4	4	0	13	4	0	0.182	0.957	1.000
211	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(1), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(1), HRAS(1), MAPK14(1), MAPK3(1), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(6)	16488524	36	36	36	7	4	5	2	23	2	0	0.291	0.958	1.000
212	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1)	11432703	16	16	16	3	2	2	4	7	1	0	0.261	0.958	1.000
213	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1), SPAM1(4)	20800172	46	37	44	8	7	6	7	22	4	0	0.0524	0.959	1.000
214	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), IL3(1), IL4(1)	3759317	4	4	4	2	0	1	1	2	0	0	0.848	0.959	1.000
215	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	15436406	23	22	22	4	2	2	3	12	4	0	0.369	0.960	1.000
216	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), PRF1(1)	6511345	5	5	5	0	0	2	1	2	0	0	0.193	0.960	1.000
217	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2)	5230020	8	8	8	3	0	2	0	3	3	0	0.822	0.961	1.000
218	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(2)	3799740	8	8	8	3	1	0	4	1	2	0	0.701	0.965	1.000
219	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(2), ATIC(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3)	11147479	15	15	15	3	3	2	0	7	3	0	0.392	0.965	1.000
220	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(2), EGF(4), EGFR(7), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTK2(1), TLN1(4)	20377128	40	39	39	7	6	4	4	18	8	0	0.200	0.965	1.000
221	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(2)	3640818	4	4	4	2	1	2	0	1	0	0	0.656	0.966	1.000
222	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(2)	3640818	4	4	4	2	1	2	0	1	0	0	0.656	0.966	1.000
223	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(2), ATIC(1), FTCD(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3)	11799824	16	16	16	3	3	2	0	8	3	0	0.358	0.966	1.000
224	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(5), ACADM(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2)	16448248	33	31	33	7	3	5	11	10	4	0	0.163	0.968	1.000
225	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	DAXX(4), FAS(1), FASLG(1), HSPB2(1)	6815254	7	7	7	2	1	1	1	4	0	0	0.625	0.969	1.000
226	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2)	3382326	7	7	7	3	0	2	1	4	0	0	0.684	0.970	1.000
227	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), MAP3K1(4), MAP3K14(1), NFKB1(1), RELA(1), TRAF3(1), TRAF6(1)	11335637	12	12	12	2	0	3	0	3	6	0	0.446	0.970	1.000
228	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(3), FBP1(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(2), PKM2(1), RPE(1), TPI1(1)	10998103	23	22	23	6	0	3	4	6	10	0	0.608	0.974	1.000
229	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(6), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(2), GNAI1(1), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2)	17218456	28	28	28	5	2	7	4	12	3	0	0.0733	0.974	1.000
230	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(2), HRAS(1), KLK2(1), MAPK3(1), NGFR(1)	4965774	7	7	7	3	2	1	0	4	0	0	0.757	0.974	1.000
231	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TLR10(1), TLR2(2), TLR4(2), TLR6(1), TLR7(2), TLR9(1), TRAF6(1)	22241562	31	29	31	4	2	6	1	14	8	0	0.112	0.975	1.000
232	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(1), TPH1(1)	3613727	4	4	4	2	0	1	1	1	1	0	0.864	0.976	1.000
233	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(6), RPE(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), XYLB(1)	16942394	32	28	30	6	2	5	6	12	7	0	0.227	0.977	1.000
234	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LDLR(1), LPL(1)	3253171	3	3	3	2	0	2	0	1	0	0	0.850	0.979	1.000
235	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHB(1), SDHD(1)	4061439	4	4	4	2	1	0	1	2	0	0	0.799	0.980	1.000
236	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6143964	9	9	9	3	2	1	1	5	0	0	0.600	0.980	1.000
237	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), IFNB1(2), NFKB1(1), RELA(1), TRAF6(1)	6682612	6	6	6	2	0	4	0	1	1	0	0.664	0.982	1.000
238	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3R1(2), RAC1(1), RALBP1(1), RELA(1)	10574246	13	13	13	3	1	5	0	5	2	0	0.504	0.982	1.000
239	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(3), FBP1(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME3(2), PGK1(2), PKM2(1), RPE(1), TKTL1(1), TKTL2(3), TPI1(1)	12309174	25	25	25	6	0	2	4	8	11	0	0.612	0.982	1.000
240	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), DDC(2), EPX(1), GOT1(2), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TPO(3)	13461982	28	24	28	6	2	4	9	11	2	0	0.207	0.984	1.000
241	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(2), BCAR1(3), GRB2(1), ILK(1), ITGB1(3), MAPK3(1), PDK2(1), PIK3R1(2), PTK2(1), SHC1(2), SOS1(6)	9909567	23	21	23	6	2	5	2	12	2	0	0.537	0.984	1.000
242	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KA1(2), SRC(2)	12410831	27	26	27	6	4	3	0	18	2	0	0.389	0.984	1.000
243	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCR(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAP3K1(4), MAPK3(1), MYC(1), PIK3R1(2), SOS1(6), STAT1(4), STAT5B(1)	15645987	31	31	31	6	2	4	2	20	3	0	0.281	0.984	1.000
244	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), RIPK1(1), TNFRSF1A(1), TRADD(1)	4852865	6	6	6	3	0	3	1	1	1	0	0.770	0.985	1.000
245	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT3(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1)	4775395	4	4	4	4	0	0	1	1	2	0	0.986	0.985	1.000
246	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(2), ALOX5(2), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1)	9356670	20	19	19	5	1	3	6	6	4	0	0.386	0.986	1.000
247	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(2), JAK1(4), PTPRU(4), STAT1(4), STAT2(3), TYK2(3)	7631359	21	21	21	6	1	2	2	11	5	0	0.560	0.986	1.000
248	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), PER1(4), PER2(3), PER3(1)	10468412	10	10	10	2	0	0	4	4	1	1	0.399	0.986	1.000
249	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3R1(2), SYT1(1), TRAF3(1), TRAF5(3), TRAF6(1)	18912175	24	23	24	3	4	4	1	12	3	0	0.0545	0.987	1.000
250	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), PRKCE(2)	4893734	8	8	8	4	0	0	1	5	2	0	0.939	0.987	1.000
251	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(1), P2RY2(1)	3391119	3	3	3	5	0	0	0	2	1	0	0.994	0.988	1.000
252	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(1), CHST7(1), CHSY1(2), DSE(1), XYLT1(1), XYLT2(2)	7571863	13	13	13	4	2	4	0	5	2	0	0.433	0.989	1.000
253	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), ITPKA(1), ITPKB(1)	3566789	3	3	3	2	1	0	0	1	1	0	0.926	0.990	1.000
254	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(3)	10984503	16	16	16	4	1	5	1	6	3	0	0.495	0.991	1.000
255	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), B3GNT7(1), B4GALT3(1), B4GALT4(2), CHST1(1), CHST4(1), ST3GAL1(1), ST3GAL3(1)	7106875	10	10	10	4	0	3	2	1	4	0	0.798	0.991	1.000
256	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), DDC(2), EPX(1), ESCO1(2), ESCO2(1), GOT1(2), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), TPO(3)	20920218	40	35	40	7	3	5	10	18	4	0	0.0994	0.991	1.000
257	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSD(1), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	16843009	19	18	19	3	1	2	3	6	7	0	0.290	0.992	1.000
258	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), GRB2(1), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1)	10810069	22	21	22	5	3	3	3	11	2	0	0.377	0.992	1.000
259	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(3), MAPK3(1), STAT3(1), TYK2(3)	7221566	17	17	17	8	1	0	3	9	4	0	0.939	0.992	1.000
260	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2I(3), GTF2IRD1(1), STON1(1), TAF1(5), TAF13(1), TAF1L(4), TAF2(2), TAF4(2), TAF4B(2), TAF5(2), TAF5L(2), TAF6(1), TAF7L(4)	22125447	37	36	37	6	2	4	4	22	5	0	0.160	0.993	1.000
261	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT1(2), AKT2(3), AKT3(2), GRB2(1), GSK3A(2), IL4R(2), IRS1(3), JAK1(4), JAK3(3), MAP4K1(1), MAPK3(1), PDK1(1), PIK3R1(2), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), STAT6(2)	20284473	41	39	41	8	4	8	4	19	6	0	0.161	0.993	1.000
262	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(4), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(4), MAPK3(1), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1)	21689786	44	44	43	9	4	7	4	20	9	0	0.269	0.994	1.000
263	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), IDI1(1), IDI2(2), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1)	11924405	12	12	12	2	0	0	1	8	3	0	0.591	0.995	1.000
264	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(15), BMPR1B(1), CCND2(1), CDK4(1), EGR1(2), ESR2(1), GJA4(1), MLH1(1), NCOR1(3), NRIP1(6), PGR(1), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1)	21016551	39	34	39	6	2	6	6	16	9	0	0.0707	0.995	1.000
265	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(15), CDC25A(1), CDC25C(2), CDK2(2), CDK4(1), MYT1(2), RB1(1), WEE1(1)	10515183	25	22	25	7	0	3	4	11	7	0	0.669	0.995	1.000
266	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	4476618	5	5	5	3	0	1	0	3	1	0	0.949	0.995	1.000
267	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GFPT1(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2)	10526097	13	12	13	3	3	0	2	6	2	0	0.488	0.995	1.000
268	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BID(1), CASP8AP2(4), CES1(2)	7145394	8	8	8	3	0	1	0	4	3	0	0.874	0.996	1.000
269	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1)	4381376	9	9	9	4	0	0	1	7	1	0	0.921	0.996	1.000
270	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), PON3(2)	10895365	19	18	19	5	1	5	2	9	2	0	0.407	0.996	1.000
271	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	ELK1(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SLC2A4(1), SOS1(6), SRF(1)	14008267	28	27	28	7	3	9	3	12	1	0	0.276	0.996	1.000
272	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(4), EP300(6), MAP2K3(3), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR2(1), TLR2(2)	18349352	23	23	23	4	1	3	4	11	4	0	0.328	0.996	1.000
273	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(1), AGTR1(1), BDKRB2(1), KNG1(2), NOS3(2), REN(1)	5996482	10	9	10	4	1	2	2	4	1	0	0.701	0.996	1.000
274	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(1), RELN(3), VLDLR(2)	8652493	10	10	10	3	0	3	0	5	2	0	0.822	0.996	1.000
275	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(3), CRHR2(1), ELTD1(2), EMR1(1), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(2), LPHN3(7), SCTR(1), VIPR1(1)	17047766	30	28	30	6	3	4	3	16	4	0	0.186	0.996	1.000
276	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F2(3), FGA(1), FGG(1), PLAT(2), PLAU(4), PLG(5)	8404887	16	16	16	5	0	1	3	8	4	0	0.737	0.997	1.000
277	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(4), ALAS2(3), CPOX(1), FECH(2)	4773876	10	10	9	4	0	0	2	7	1	0	0.833	0.997	1.000
278	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1)	8252375	13	13	12	5	1	1	0	7	4	0	0.910	0.997	1.000
279	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(5), DDX20(4), E2F1(1), HRAS(1), JUN(2), NCOR2(4), RBL2(2), SIN3A(1), SIN3B(1)	16312283	21	21	21	4	0	3	2	12	4	0	0.290	0.997	1.000
280	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(4), ACSS1(3), ACSS2(3), IDH1(2), MDH1(1)	8259902	16	15	16	5	1	3	2	7	3	0	0.594	0.997	1.000
281	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(4), EP300(6), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1)	13582745	17	17	17	4	0	4	5	5	3	0	0.397	0.998	1.000
282	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	4892942	7	7	7	5	0	1	1	4	1	0	0.971	0.998	1.000
283	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	4892942	7	7	7	5	0	1	1	4	1	0	0.971	0.998	1.000
284	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK4(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(3), FGF2(1), GATA4(1), HRAS(1), MAPK14(1), MAPK3(1), MYH2(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NPPA(1), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KB1(1), SYT1(1)	29417816	52	48	52	9	6	6	5	25	10	0	0.0910	0.998	1.000
285	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(3), GRB2(1), GSK3A(2), IARS(4), INPP5D(1), PDK1(1), PPP1R13B(3), RPS6KA1(2), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), TEC(5), YWHAE(1)	20320776	42	37	42	9	2	9	4	19	8	0	0.293	0.998	1.000
286	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(3)	9325297	13	13	13	4	0	3	0	7	3	0	0.754	0.998	1.000
287	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(2), ITGB1(3), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(1), PIK3R1(2), PTK2B(2), PTPN6(3), RAC1(1), SYK(1), VAV1(2)	10216435	24	20	23	7	2	5	3	7	7	0	0.641	0.998	1.000
288	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(1), RELA(1)	5102963	3	3	3	3	0	2	0	0	1	0	0.921	0.998	1.000
289	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HARS(1), MAOA(1), PRPS1(1), PRPS2(2)	15001144	29	27	29	7	2	6	7	12	2	0	0.269	0.998	1.000
290	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(1)	4578285	7	6	7	5	1	0	2	3	1	0	0.951	0.998	1.000
291	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(4), MAPK3(1), PDGFRA(7), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1)	20119956	40	39	40	9	3	6	2	21	8	0	0.354	0.998	1.000
292	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(5), JAK3(3), PIAS1(2), PTPRU(4)	8521358	18	15	18	5	0	1	3	10	4	0	0.656	0.998	1.000
293	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), LTA(1), MAP3K1(4), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1)	13819333	14	14	14	3	1	3	0	4	6	0	0.455	0.998	1.000
294	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(15), ATR(5), BRCA1(6), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(6), MYT1(2), PRKDC(5), RPS6KA1(2), WEE1(1)	26213274	47	41	47	7	1	5	7	26	8	0	0.114	0.998	1.000
295	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), NFAT5(7), PDE6A(1), PDE6B(2), PDE6C(2), SLC6A13(2)	22326766	34	30	33	6	4	3	6	17	4	0	0.121	0.998	1.000
296	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), DLD(2), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HADHB(2), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	26726464	46	46	45	9	4	7	10	19	6	0	0.140	0.998	1.000
297	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	JUN(2), KEAP1(2), MAPK14(1), NFE2L2(6)	5381736	11	11	11	5	0	1	2	7	1	0	0.864	0.998	1.000
298	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(2), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(1), HARS(1), HARS2(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1)	24273581	42	36	42	7	3	10	8	17	4	0	0.0534	0.998	1.000
299	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), C8B(2), MASP1(1)	12799458	21	21	21	5	4	5	1	9	2	0	0.321	0.999	1.000
300	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(1)	9811377	18	17	18	7	1	3	2	7	5	0	0.818	0.999	1.000
301	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(2), AKT2(3), AKT3(2), BRD4(5), CBL(1), CDC42(1), CDKN2A(3), F2RL2(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), LNPEP(3), MAPK3(1), PARD3(2), PDK1(1), PIK3R1(2), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(1), YWHAE(1)	33426584	52	49	52	8	4	9	8	23	8	0	0.0456	0.999	1.000
302	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(6), AR(1), ASAH1(1), BRAF(1), EGFR(7), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3R1(2), PITX2(1), SRC(2)	31660609	48	41	47	7	5	10	8	21	4	0	0.0139	0.999	1.000
303	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(3)	7158734	10	10	10	4	1	3	1	2	3	0	0.785	0.999	1.000
304	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(1), CFL1(1), CHN1(2), MAP3K1(4), MYL2(1), MYLK(4), NCF2(1), PAK1(1), PDGFRA(7), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(2)	20338393	33	30	33	6	1	2	2	18	10	0	0.372	0.999	1.000
305	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1A(1), PDE1B(2), PLCB1(1), PLCB2(2)	6781922	8	8	8	5	1	1	0	4	2	0	0.932	0.999	1.000
306	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3R1(2), RELA(1), SYT1(1)	9632644	19	19	19	5	1	6	1	9	2	0	0.554	0.999	1.000
307	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNGR1(2), IFNGR2(1), JAK2(5), NFKB1(1), RB1(1), RELA(1), TNFRSF1A(1), USH1C(3), WT1(3)	10475201	19	19	19	8	0	4	2	8	5	0	0.900	0.999	1.000
308	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(4), GRIN2B(5), NOS1(8), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1)	15677959	33	32	33	9	6	7	1	19	0	0	0.362	0.999	1.000
309	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), MASP1(1), MASP2(1), MBL2(1)	13155421	21	21	21	5	3	6	1	9	2	0	0.307	0.999	1.000
310	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3E(2), CD3G(1), CD4(2), IL12RB1(1), IL12RB2(2), JAK2(5), STAT4(1), TYK2(3)	9171081	17	16	17	5	1	2	3	9	2	0	0.597	0.999	1.000
311	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), ECHS1(2), EHHADH(2), ESCO1(2), ESCO2(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1)	19051907	28	26	28	5	2	4	4	13	5	0	0.245	0.999	1.000
312	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(2), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2)	17731273	34	32	34	9	3	5	12	11	3	0	0.307	0.999	1.000
313	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	0.999	1.000
314	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	0.999	1.000
315	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	0.999	1.000
316	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), MDH1(1), ME1(1), PC(1), PDHA1(1)	5716800	8	8	8	4	0	3	0	4	1	0	0.761	0.999	1.000
317	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), ECHS1(2), EHHADH(2), HADHA(1), HADHB(2), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	22330728	40	40	39	9	3	7	8	17	5	0	0.270	0.999	1.000
318	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1)	14030803	32	31	32	7	2	3	6	17	4	0	0.290	0.999	1.000
319	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(4), JAK2(5), JAK3(3), PTPRU(4), SRC(2), STAT3(1)	9373255	19	17	19	8	0	2	2	11	4	0	0.917	0.999	1.000
320	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(1)	7410165	13	13	13	5	0	4	3	4	2	0	0.751	1.000	1.000
321	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), MDH1(1), OGDH(3)	5886443	5	5	5	5	0	1	0	3	1	0	0.990	1.000	1.000
322	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(1), PDK2(1), PIK3R1(2), PPP2CA(1), RPS6KB1(1), TSC1(2), TSC2(4)	15314405	26	25	26	6	1	4	3	13	5	0	0.353	1.000	1.000
323	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25C(2), CSK(2), GRB2(1), PTPRA(1), SRC(2)	5682399	9	9	9	4	0	4	0	5	0	0	0.731	1.000	1.000
324	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(4), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC5(1), ST8SIA1(2), ST8SIA5(1)	9926916	20	19	20	6	2	4	2	10	2	0	0.425	1.000	1.000
325	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY6(1), ADCY8(6), CACNA1A(5), CACNA1B(3), GNAS(4), GNB1(2), GNG3(1), GRM4(3), ITPR3(3), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(4), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(1)	35196925	68	60	67	11	13	4	7	29	15	0	0.0642	1.000	1.000
326	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD33(1), IFNA1(2), IFNB1(2), IL3(1), IL4(1), ITGAX(2), TLR2(2), TLR4(2), TLR7(2), TLR9(1)	11312503	22	22	22	7	2	5	5	9	1	0	0.568	1.000	1.000
327	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(4)	6297228	4	3	4	3	2	0	0	1	1	0	0.925	1.000	1.000
328	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9951143	13	13	13	6	0	1	3	5	4	0	0.924	1.000	1.000
329	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELE(4)	7632567	14	14	14	5	1	4	4	3	2	0	0.647	1.000	1.000
330	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(1), ASPH(3), COPS5(1), EP300(6), HIF1A(3), JUN(2), NOS3(2)	10317691	18	18	18	8	0	0	5	9	4	0	0.914	1.000	1.000
331	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(6), ATF2(1), AXIN1(2), BMP2(1), BMP5(1), BMP7(2), BMPR2(4), CHRD(2), CTNNB1(1), DVL1(1), FZD1(2), GATA4(1), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1)	22030650	37	35	37	7	2	6	3	23	3	0	0.168	1.000	1.000
332	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(1), TRAF6(1)	14751144	19	18	19	6	1	5	1	4	8	0	0.652	1.000	1.000
333	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(1), TPH1(1)	8603208	13	12	13	6	0	2	4	4	3	0	0.881	1.000	1.000
334	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), JUN(2), LTA(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1)	14782944	24	24	24	6	2	3	1	12	6	0	0.615	1.000	1.000
335	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2)	12255271	17	17	17	8	0	3	2	6	6	0	0.922	1.000	1.000
336	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), ROCK1(4)	12616665	21	21	21	7	0	1	0	14	6	0	0.835	1.000	1.000
337	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(2), PLCB1(1), VAV1(2)	6652765	7	7	7	8	1	2	1	2	1	0	0.990	1.000	1.000
338	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), GRB2(1), HRAS(1), MAPK3(1), MEF2A(1), MEF2D(1), NTRK1(4), PIK3R1(2), RPS6KA1(2), SHC1(2)	10437894	17	17	17	5	4	3	1	7	2	0	0.551	1.000	1.000
339	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PITX2(1), PLD1(2), PLD2(2), PLD3(3)	27547566	39	32	39	6	3	8	6	16	6	0	0.0323	1.000	1.000
340	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(6), AXIN1(2), CREBBP(4), CTNNB1(1), DVL1(1), EP300(6), FZD1(2), HDAC1(2), LDB1(1), LEF1(1), PITX2(1), TRRAP(3)	20298608	30	29	30	6	1	3	7	18	1	0	0.209	1.000	1.000
341	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(2), GHR(1), HRAS(1), PIK3R1(2), SHC1(2)	6681392	10	10	10	6	1	2	1	5	1	0	0.935	1.000	1.000
342	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(4), LCT(2), MPI(1), PYGL(1), PYGM(2), TPI1(1)	8385889	15	14	15	5	3	0	4	6	2	0	0.611	1.000	1.000
343	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(3), AKT3(2), BRAF(1), FIGF(2), HIF1A(3), MAPK3(1), PGF(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RICTOR(3), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(2), TSC2(4), ULK1(1), ULK2(1), ULK3(3)	31196174	46	44	45	8	5	8	5	20	8	0	0.0714	1.000	1.000
344	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(2), CBR1(2), CYP4F2(1), EPX(1), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(1), PTGS2(4), TBXAS1(1), TPO(3)	17084735	31	31	30	8	4	5	8	10	4	0	0.280	1.000	1.000
345	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(4), IMPA2(2)	7125667	6	5	6	4	3	0	0	2	1	0	0.924	1.000	1.000
346	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(6), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), NOTCH1(3)	12458770	18	18	17	5	1	3	3	11	0	0	0.477	1.000	1.000
347	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(1), SNX13(2), SRC(2)	7140864	7	7	7	5	0	3	0	3	1	0	0.948	1.000	1.000
348	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), PSMD11(1), PSMD2(2), PSMD6(1)	9978802	14	14	14	5	1	2	1	7	3	0	0.853	1.000	1.000
349	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), SELE(4), SELP(1)	10101136	18	18	18	7	1	5	5	4	3	0	0.750	1.000	1.000
350	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(1), EIF2S2(1), EIF4E(1), INPPL1(2), PDK2(1), PIK3R1(2), PPP2CA(1), RPS6KB1(1)	10284746	12	12	12	5	0	3	0	6	3	0	0.755	1.000	1.000
351	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), CS(1), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2)	7967216	14	14	14	5	3	1	1	8	1	0	0.670	1.000	1.000
352	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(4), C7(2), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELP(1), SELPLG(1), VCAM1(1)	15393560	24	24	24	7	2	4	4	10	4	0	0.507	1.000	1.000
353	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), HADHA(1)	7514224	12	12	12	5	1	3	2	5	1	0	0.764	1.000	1.000
354	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), CS(1), DLD(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(1), PCK1(4), SDHB(1), SUCLG1(5), SUCLG2(1)	12807968	24	23	24	8	2	1	3	13	5	0	0.753	1.000	1.000
355	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKL(1), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2), TKTL1(1), TKTL2(3)	14777530	22	22	22	8	0	4	2	9	7	0	0.818	1.000	1.000
356	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP3K1(4), MAPK3(1), NFKB1(1), NSMAF(3), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1)	12585853	14	14	14	5	1	4	1	3	5	0	0.598	1.000	1.000
357	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(15), ATR(5), CCNA1(3), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), E2F1(1), HDAC1(2), RB1(1), SKP2(1), TGFB2(2), TGFB3(1)	17966362	45	41	45	10	2	8	5	18	12	0	0.365	1.000	1.000
358	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(2), CD3G(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(3)	11604034	20	19	20	6	1	1	3	13	2	0	0.706	1.000	1.000
359	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), CS(1), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2)	8361460	14	14	14	5	3	1	1	8	1	0	0.668	1.000	1.000
360	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(2), ILVBL(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1), VARS(2), VARS2(1)	10458655	16	14	16	7	0	4	1	8	3	0	0.836	1.000	1.000
361	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), CRAT(1), DARS(1), GAD2(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), PC(1)	16111652	22	21	22	7	1	2	7	4	8	0	0.613	1.000	1.000
362	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT3(1), B4GALT5(1), DPAGT1(2), DPM1(1), MAN1A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), RPN1(2), RPN2(1)	11842267	17	17	17	9	0	4	0	9	4	0	0.951	1.000	1.000
363	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(1), ARHGEF1(1), F2(3), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3R1(2), PLCB1(1), PTK2B(2), ROCK1(4)	14491085	22	21	22	8	0	3	1	12	6	0	0.799	1.000	1.000
364	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), ILVBL(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2), VNN1(1)	10603495	17	16	17	6	1	3	4	6	3	0	0.710	1.000	1.000
365	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), FYN(1), ITGA1(3), ITGB1(3), L1CAM(4), SELP(1)	9750850	13	13	13	8	2	2	1	6	2	0	0.963	1.000	1.000
366	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(1), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1)	8078902	8	8	8	5	2	3	0	2	1	0	0.875	1.000	1.000
367	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), DPM2(1), GRB2(1), HRAS(1), KLK2(1), NTRK1(4), PIK3R1(2), SHC1(2), SOS1(6)	8152862	20	19	20	8	1	5	2	11	1	0	0.821	1.000	1.000
368	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(2)	11750482	19	19	19	6	1	3	2	13	0	0	0.630	1.000	1.000
369	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(4), FLT4(6), KDR(5), NOS3(2), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKG1(2), PRKG2(2), RYR2(9), SLC7A1(1), SYT1(1), TNNI1(1)	25547675	55	51	55	12	11	8	6	24	6	0	0.125	1.000	1.000
370	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3)	17764358	31	28	31	8	4	9	0	15	3	0	0.228	1.000	1.000
371	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	30876617	41	38	41	8	4	5	6	18	8	0	0.242	1.000	1.000
372	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(2), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(3), FLNC(4), FSCN1(3), MYH2(7), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6)	28974920	52	46	52	10	3	12	3	22	12	0	0.136	1.000	1.000
373	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(2), ABCC2(1), BCHE(2), CES1(2), CES2(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2)	14211148	17	15	17	5	1	3	3	5	5	0	0.688	1.000	1.000
374	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(2), SHC1(2), SOS1(6), SYK(1), VAV1(2), VAV2(4)	19485389	32	29	32	8	4	5	3	17	3	0	0.332	1.000	1.000
375	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(1), PIK3R1(2), RAC1(1), RB1(1), RELA(1)	11192094	18	17	18	6	2	5	1	7	3	0	0.660	1.000	1.000
376	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(1), AKT1(2), CSF2RB(1), IL3(1), KIT(3), KITLG(2), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	12056378	21	21	21	7	3	2	1	14	1	0	0.646	1.000	1.000
377	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(1), ALAS1(4), ALAS2(3), AOC2(2), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), MAOA(1), PISD(1), PLCB2(2), PLCG2(1), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2)	26059364	49	46	48	10	3	7	12	22	5	0	0.123	1.000	1.000
378	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(1), ADRB2(2), CHRM2(2), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1)	15295241	26	25	26	8	4	3	2	13	4	0	0.559	1.000	1.000
379	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(1), CDC42(1), CFL1(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(3), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(2), WASL(6)	41649360	70	58	70	11	3	18	8	30	11	0	0.0101	1.000	1.000
380	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), ATM(15), BID(1), CASP7(1), PTK2(1), STAT1(4), TLN1(4)	16583824	28	24	28	7	2	4	3	13	6	0	0.511	1.000	1.000
381	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ASL(1), CPS1(5), GATM(2), ODC1(1), OTC(1), PYCR1(1), SMS(2)	10815043	15	15	15	7	0	1	3	9	2	0	0.933	1.000	1.000
382	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(6), RARA(4), TBP(1)	15541685	26	23	26	9	1	4	6	9	6	0	0.600	1.000	1.000
383	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(6), ASAH1(1), DLG4(1), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PITX2(1), RAC1(1), RHO(1), RYR1(11)	28105820	42	39	42	9	7	6	6	19	4	0	0.124	1.000	1.000
384	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), CHRNB1(1), PIK3R1(2), PTK2(1), PTK2B(2), SRC(2), TERT(4)	8858446	14	14	14	5	2	7	0	4	1	0	0.603	1.000	1.000
385	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), RELA(1)	9302000	10	10	10	5	3	2	0	4	1	0	0.787	1.000	1.000
386	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(3), AKT3(2), GRB2(1), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(3), PPP1R13B(3), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT6(2), TYK2(3)	21260586	49	45	49	11	2	9	7	22	9	0	0.302	1.000	1.000
387	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(6), MAPK3(1), PELP1(1), SRC(2)	9176202	14	14	14	5	1	3	4	5	1	0	0.666	1.000	1.000
388	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), GOT1(2), GOT2(2), HGD(1), MAOA(1), TH(1), TPO(3), TYR(3)	19435512	45	39	44	12	3	5	8	20	9	0	0.533	1.000	1.000
389	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2), OPLAH(2), TXNDC12(1)	13487704	24	22	24	9	1	0	6	12	5	0	0.895	1.000	1.000
390	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), ILK(1), POLR1A(2), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(2), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TBP(1)	21473327	33	32	33	8	0	5	4	16	8	0	0.380	1.000	1.000
391	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), HADHB(2), SOAT2(3)	14365999	19	18	18	8	1	2	2	10	4	0	0.942	1.000	1.000
392	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(2)	13113172	19	19	19	6	1	3	2	13	0	0	0.628	1.000	1.000
393	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CPOX(1), EPRS(2), FECH(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	16974408	27	24	25	8	2	4	4	12	5	0	0.625	1.000	1.000
394	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADS(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(2), HADHA(1), PECR(1), SCP2(2)	10425285	12	12	11	5	2	4	2	3	1	0	0.624	1.000	1.000
395	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2)	10379706	13	12	13	6	1	2	1	8	1	0	0.797	1.000	1.000
396	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(3), JUN(2), MAPK3(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1)	14274671	26	25	26	9	3	4	2	13	4	0	0.743	1.000	1.000
397	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(3), FASN(3), OXSM(1)	9684314	11	11	11	5	1	0	4	5	1	0	0.827	1.000	1.000
398	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), ARF1(1), BTK(1), EEA1(5), GSK3A(2), PFKL(1), PFKM(2), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(4)	15614399	26	24	26	9	1	5	3	12	5	0	0.729	1.000	1.000
399	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1)	14356401	23	22	23	8	2	3	4	10	4	0	0.716	1.000	1.000
400	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), EDNRB(1), EGF(4), EGFR(7), HRAS(1), JUN(2), MYC(1), NFKB1(1), RELA(1)	12588662	20	20	19	8	1	3	4	9	3	0	0.802	1.000	1.000
401	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(3), AKT1(2), AKT2(3), AKT3(2), ATM(15), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(2), IRAK4(1), MAP3K14(1), NFKB1(1), NTRK1(4), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TRADD(1)	49795331	89	80	87	15	6	15	11	42	15	0	0.0336	1.000	1.000
402	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(1), DUSP4(1), DUSP9(1), EIF4E(1), GRB2(1), MAPK3(1), MKNK1(1), MKNK2(1), NFKB1(1), RAP1A(1), RPS6KA1(2), SHC1(2), SOS1(6), SOS2(1), TRAF3(1)	18245304	24	24	24	7	3	3	3	13	2	0	0.606	1.000	1.000
403	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), HADHB(2), RDH11(3), SLC27A5(2), SOAT2(3)	19572845	27	26	26	8	3	3	2	14	5	0	0.686	1.000	1.000
404	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(1), CFLAR(1), DAXX(4), JUN(2), LMNB1(1), MAP3K1(4), MAP3K7(1), PAK1(1), PRKDC(5), PTPN13(7), RB1(1), RIPK2(1), SPTAN1(5)	26303460	38	35	38	8	2	4	4	20	8	0	0.343	1.000	1.000
405	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(1), ESCO1(2), ESCO2(1), GOT1(2), GOT2(2), HGD(1), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(4), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(1), TPO(3), TYR(3), TYRP1(1)	36430512	72	60	71	15	5	8	13	34	12	0	0.201	1.000	1.000
406	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1)	15100204	24	23	24	9	2	4	4	11	2	1	0.736	1.000	1.000
407	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGT(1), AGTR1(1), ANPEP(6), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(3), REN(1)	13008111	25	23	24	9	1	2	8	12	2	0	0.794	1.000	1.000
408	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1)	15916381	22	21	21	8	4	3	4	7	4	0	0.676	1.000	1.000
409	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2A1(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), DAXX(4), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(4), PTPN13(7), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1)	26758848	34	33	34	8	2	4	4	18	6	0	0.453	1.000	1.000
410	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), LMNB1(1), PRF1(1)	11766669	14	14	14	5	0	4	2	7	1	0	0.724	1.000	1.000
411	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), CASP1(1), CASP7(1), INSR(3), MAGI1(2), MAGI2(3), RERE(2), WWP2(2)	14624161	15	15	14	7	2	2	2	6	3	0	0.932	1.000	1.000
412	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(7), ELK1(1), GNAS(4), GNB1(2), GRB2(1), HRAS(1), ITGB1(3), KLK2(1), MAPK3(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(3), RPS6KA1(2), SHC1(2), SOS1(6), SRC(2), STAT3(1)	20205250	50	47	49	13	4	10	6	25	5	0	0.342	1.000	1.000
413	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(2), EHMT1(1), EHMT2(3), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SHMT1(2), SHMT2(3), TMLHE(1)	21926674	42	39	42	11	4	8	4	16	10	0	0.356	1.000	1.000
414	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), ATF2(1), CALM2(1), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), MEF2A(1), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1)	20918023	39	36	38	10	5	9	5	16	4	0	0.374	1.000	1.000
415	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), GAS2(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFSF10(1), TRADD(1)	20635809	25	24	25	8	1	4	3	11	6	0	0.711	1.000	1.000
416	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3)	14822445	19	19	19	7	3	2	2	10	2	0	0.670	1.000	1.000
417	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(4), EP300(6), FYN(1), JAK1(4), JAK3(3), PIK3R1(2), PTK2B(2), STAT5B(1)	16024039	23	22	23	9	0	4	5	11	3	0	0.849	1.000	1.000
418	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(2), CFLAR(1), JUN(2), MAP3K7(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1)	16105509	18	18	18	8	0	5	3	7	3	0	0.803	1.000	1.000
419	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(10), SCARB1(2)	16773628	23	23	23	8	2	4	3	10	4	0	0.761	1.000	1.000
420	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(2), ARHGEF11(3), CDC42(1), DLG4(1), GNA13(4), LPA(2), MAP3K1(4), MAP3K5(5), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(1)	30052384	53	48	53	11	2	6	6	27	12	0	0.254	1.000	1.000
421	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1)	13158828	23	22	23	8	2	4	3	12	2	0	0.729	1.000	1.000
422	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(2), AKT2(3), AKT3(2), CCL3(1), CD86(1), CHUK(1), CXCL11(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IKBKE(1), IRAK1(3), IRAK4(1), JUN(2), LBP(1), LY96(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(1), RIPK1(1), SPP1(2), STAT1(4), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(2), TLR8(4), TLR9(1), TRAF3(1), TRAF6(1)	53299594	85	77	84	14	6	15	10	47	7	0	0.0196	1.000	1.000
423	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(9), B3GALT4(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(2), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), SLC36A2(1), TSPAN9(1), UBC(2)	32558147	61	56	60	12	5	5	15	25	11	0	0.0998	1.000	1.000
424	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(2), NFATC3(3), NR2C2(1), PAPPA(1), SHC1(2), TRAF6(1), ZAK(1)	30246434	54	49	53	11	4	4	9	27	10	0	0.244	1.000	1.000
425	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(15), ATR(5), BRCA1(6), BRCA2(8), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), RAD17(1), RAD50(4), RAD51(2), TREX1(1)	26859995	56	47	56	11	2	10	7	26	11	0	0.271	1.000	1.000
426	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5M(2), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2)	35180639	55	52	55	11	2	10	11	19	13	0	0.0717	1.000	1.000
427	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(1), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(1), HERPUD1(1), HSPA8(6), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(6)	22468697	50	45	50	12	1	8	10	19	11	1	0.286	1.000	1.000
428	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), JUN(2), LMNB1(1), MADD(4), MAP3K1(4), MAP3K7(1), PAK1(1), PRKDC(5), RB1(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1)	24293467	30	29	30	8	1	6	4	12	7	0	0.490	1.000	1.000
429	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(15), BRCA1(6), CDKN1A(1), CHEK2(1), JUN(2), NFKB1(1), RAD50(4), RAD51(2), RELA(1), TP73(3)	17676268	40	35	40	10	2	7	5	18	8	0	0.478	1.000	1.000
430	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(1), CAD(4), CPS1(5), EPRS(2), GAD2(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(2), GOT1(2), GOT2(2), GPT(1), GPT2(1), GSR(1), GSS(1), NAGK(2)	24484622	32	28	32	9	2	4	7	14	5	0	0.495	1.000	1.000
431	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(4), ALAS2(3), BLVRA(1), COX15(1), CPOX(1), EPRS(2), FECH(2), FTMT(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	26178342	48	44	45	12	3	7	7	24	7	0	0.371	1.000	1.000
432	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(4), CPS1(5), EPRS(2), GAD2(1), GFPT1(1), GLS(4), GLS2(2), GOT1(2), GOT2(2), GPT(1), GPT2(1), GSS(1)	20557233	28	25	28	9	1	4	5	13	5	0	0.663	1.000	1.000
433	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM2(1), EP300(6), HDAC1(2), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1)	14635976	20	19	20	8	3	2	3	11	1	0	0.764	1.000	1.000
434	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADS(2), ACOX1(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1)	30408563	42	42	40	10	5	6	8	16	7	0	0.250	1.000	1.000
435	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLG(2), POLG2(4), POLH(4), POLI(3), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM1(2), PRIM2(3), REV1(1), REV3L(2), RFC5(1)	25562950	43	41	43	10	4	3	4	21	11	0	0.485	1.000	1.000
436	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(4), DARS(1), EPRS(2), HARS(1), IARS(4), KARS(1), LARS(1), LARS2(1), MARS(2), MARS2(3), SARS(3), TARS(2), WARS2(1), YARS(1)	19909360	28	27	28	9	0	4	5	16	3	0	0.659	1.000	1.000
437	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(1), CHUK(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK9(2), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(1), PAK1(1), RAC1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KB1(1), RPS6KB2(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1)	59454728	95	82	94	17	11	10	7	46	21	0	0.0667	1.000	1.000
438	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), CPEB1(3), EGFR(7), ERBB2(4), ERBB4(6), ETV6(1), FMN2(5), GRB2(1), KRAS(1), MAPK3(1), NOTCH1(3), NOTCH2(7), NOTCH3(6), NOTCH4(1), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), SOS1(6), SOS2(1), SPIRE1(1), SPIRE2(1)	30577295	64	58	63	16	6	8	7	33	10	0	0.415	1.000	1.000
439	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), CABIN1(5), CALM2(1), CAMK1(1), INSR(3), MAP2K6(1), MAPK14(1), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(1), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1)	19725780	23	23	23	9	3	5	2	10	3	0	0.736	1.000	1.000
440	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(3), BDKRB1(1), BDKRB2(1), C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C3AR1(1), C4BPA(2), C5(4), C7(2), C8B(2), C8G(1), CD55(1), CFB(1), CFH(5), CR1(7), CR2(1), F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(4), PLAUR(2), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(5)	55525696	103	92	103	21	8	17	9	54	15	0	0.0747	1.000	1.000
441	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(6), AXIN1(2), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(1), GSK3A(2), LRP1(10), MVP(3), NKD1(2), NKD2(1), PTPRA(1), WIF1(1)	24960163	45	43	45	12	4	8	7	21	5	0	0.375	1.000	1.000
442	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(2), ASAH1(1), BRAF(1), DRD2(1), EGFR(7), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PIK3CB(1), PITX2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT3(1)	36079091	59	52	58	14	7	11	8	28	5	0	0.136	1.000	1.000
443	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNAI1(1), GNB1(2), GRB2(1), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(1), MYLK(4), PTK2B(2), SHC1(2), SOS1(6), STAT1(4), STAT3(1), SYT1(1)	25864845	44	41	44	12	4	6	6	23	5	0	0.464	1.000	1.000
444	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	ATM(15), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNG2(1), CD82(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(6), TP53I3(4), TP73(3), TSC2(4)	38923039	77	66	77	17	6	11	12	27	21	0	0.197	1.000	1.000
445	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASS1(2), CAD(4), CRAT(1), DARS(1), DLAT(2), DLD(2), GAD2(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHA2(1), PDHB(1)	23391226	37	31	37	10	2	2	9	12	12	0	0.486	1.000	1.000
446	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), LPA(2), PLAT(2), PLAU(4), PLG(5), SERPINF2(2), VWF(5)	21610381	40	40	40	12	2	3	8	19	8	0	0.551	1.000	1.000
447	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), DUSP10(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1)	20630113	37	34	37	10	2	6	0	23	6	0	0.519	1.000	1.000
448	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ALG6(1), CCKBR(2), CELSR1(7), CELSR2(4), CELSR3(4), CHRM2(2), CHRM3(2), CIDEB(1), EMR2(2), EMR3(5), GPR116(3), GPR133(2), GPR17(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(2), LPHN2(2), LPHN3(7), NTSR1(1), OR8G1(2), OR8G2(2), P2RY11(1), P2RY13(1), PTGFR(2), SMO(3)	39661521	68	58	68	16	9	14	6	30	9	0	0.0913	1.000	1.000
449	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(3), GAB1(1), ITPR1(2), ITPR2(8), ITPR3(3), PDK1(1), PHF11(1), PITX2(1), PLCG2(1), PPP1R13B(3), PREX1(6), PTPRC(6), RPS6KA1(2), RPS6KB1(1), SAG(2), SYK(1), TEC(5), VAV1(2)	32391646	59	53	59	15	5	12	7	25	10	0	0.201	1.000	1.000
450	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(3), F5(4), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), PROC(4), PROS1(4), SERPING1(2)	27873892	46	43	46	14	4	12	3	19	8	0	0.478	1.000	1.000
451	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(1), GMPPB(1), HK1(4), KHK(4), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(2), PGM2(2), PMM1(1), RDH11(3), SORD(2), TPI1(1)	23117498	37	36	37	11	5	3	6	14	9	0	0.569	1.000	1.000
452	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GANC(1), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(2), PFKL(1), PFKM(2), RDH11(3), UGP2(1)	23600941	33	30	33	10	3	3	6	14	7	0	0.595	1.000	1.000
453	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(3), ACSS1(3), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1)	28772098	47	43	47	13	0	7	10	15	15	0	0.532	1.000	1.000
454	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DAK(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GK2(1), GLB1(4), GPAM(1), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2)	36385524	50	46	49	13	5	8	8	19	10	0	0.372	1.000	1.000
455	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(2), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3R1(2), PLCG2(1), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2)	30553940	44	38	43	12	4	11	4	20	5	0	0.270	1.000	1.000
456	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(2), EHMT1(1), EHMT2(3), HADH(1), HADHA(1), HSD17B4(1), NSD1(4), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(3), SETD1A(2), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(3), TMLHE(1)	34935687	65	59	65	18	6	14	9	23	13	0	0.319	1.000	1.000
457	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(3), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GALM(2), GAPDHS(1), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TPI1(1)	35889358	59	52	58	16	4	5	7	25	18	0	0.599	1.000	1.000
458	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(2), CTSB(3), CTSL1(2), CTSS(1), HLA-C(2), HLA-DPA1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB5(2), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), KIR2DS4(1), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), RFX5(1)	25594534	55	50	54	17	4	8	7	27	9	0	0.756	1.000	1.000
459	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BFAR(1), BTK(1), CAD(4), CASP10(3), CASP8AP2(4), CSNK1A1(1), DAXX(4), DEDD(2), EGFR(7), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(4), MAP3K5(5), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(3), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TPX2(1)	44495974	75	65	73	17	6	7	7	40	15	0	0.282	1.000	1.000
460	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(1), ARHGEF1(1), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), CFL1(1), DIAPH1(1), GSN(1), MYL2(1), MYLK(4), OPHN1(1), PIP5K1A(2), ROCK1(4), SRC(2), TLN1(4), VCL(2)	28107592	37	36	37	10	1	6	2	19	9	0	0.578	1.000	1.000
461	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(4), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), CTNNB1(1), DIAPH1(1), DOCK1(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), FARP2(2), FIGF(2), FLNA(3), FLNB(2), FLNC(4), FLT1(4), FN1(4), FYN(1), GRB2(1), GRLF1(6), HGF(1), HRAS(1), IBSP(1), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), JUN(2), KDR(5), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), MAPK10(1), MAPK3(1), MAPK9(2), MET(3), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARVG(1), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PGF(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(1), PRKCG(1), PTK2(1), RAC1(1), RAC3(1), RAP1A(1), RAPGEF1(2), RELN(3), ROCK1(4), ROCK2(3), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SPP1(2), SRC(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TLN1(4), TLN2(6), TNC(4), TNN(3), TNR(8), TNXB(1), VAV1(2), VAV2(4), VCL(2), VTN(1), VWF(5), ZYX(1)	225773349	383	236	381	139	38	59	47	170	69	0	0.947	1.000	1.000
462	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(3), ADCY3(3), ADCY8(6), ADCY9(3), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), ATP2A1(6), ATP2A2(4), ATP2B1(1), ATP2B3(1), ATP2B4(1), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(6), CACNA1H(3), CACNA1I(4), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(7), ERBB2(4), ERBB3(3), ERBB4(6), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(4), GRM1(4), GRM5(4), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(1), PDE1A(1), PDE1B(2), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTAFR(1), PTGFR(2), PTK2B(2), RYR1(11), RYR2(9), RYR3(10), SLC25A4(2), SLC25A5(1), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), TRHR(2), TRPC1(1)	167992818	292	215	290	88	43	37	27	139	46	0	0.383	1.000	1.000
463	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(4), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ATF2(1), ATF4(1), BRAF(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(6), CACNA1H(3), CACNA1I(4), CACNA1S(7), CACNA2D1(3), CACNA2D2(1), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CDC42(1), CHUK(1), DAXX(4), DUSP10(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(7), ELK1(1), ELK4(1), FAS(1), FASLG(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(4), FGFR4(3), FLNA(3), FLNB(2), FLNC(4), GNG12(1), GRB2(1), HRAS(1), IL1R1(1), JUN(2), KRAS(1), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), MAPT(1), MAX(3), MKNK1(1), MKNK2(1), MRAS(1), MYC(1), NF1(7), NFATC2(1), NFATC4(3), NFKB1(1), NTRK1(4), PAK1(1), PDGFRA(7), PDGFRB(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAP1A(1), RAPGEF2(6), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA6(1), SOS1(6), SOS2(1), SRF(1), TAOK2(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TRAF6(1), ZAK(1)	177775510	296	213	293	83	27	39	35	140	55	0	0.390	1.000	1.000
464	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), APC(6), APC2(4), ARHGEF1(1), ARHGEF6(1), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(1), C3orf10(2), CDC42(1), CFL1(1), CHRM2(2), CHRM3(2), CHRM5(2), CSK(2), CYFIP1(4), CYFIP2(5), DIAPH1(1), DIAPH2(2), DIAPH3(3), DOCK1(1), EGF(4), EGFR(7), F2(3), FGD1(3), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(4), FGFR4(3), FN1(4), GIT1(2), GNA13(4), GNG12(1), GRLF1(6), GSN(1), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(1), LIMK2(2), MAPK3(1), MRAS(1), MSN(2), MYH14(3), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PPP1R12A(1), PTK2(1), RAC1(1), RAC3(1), RDX(1), ROCK1(4), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(6), SOS2(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(1), VAV1(2), VAV2(4), VCL(2), WASF2(1), WASL(6)	171379036	279	197	275	82	21	38	38	132	50	0	0.534	1.000	1.000
465	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), CHAD(2), COL11A1(9), COL11A2(2), COL17A1(3), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), DSC2(3), DSG1(3), DSG2(2), DSG3(1), DSG4(1), FN1(4), GJA10(1), GJA3(1), GJA4(1), GJA5(3), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(1), KRT19(1), KRT2(3), KRT23(1), KRT24(1), KRT27(1), KRT28(1), KRT3(1), KRT31(1), KRT35(1), KRT36(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(3), KRT77(1), KRT78(1), KRT79(2), KRT82(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), LMNB1(1), NES(5), PRPH(1), RELN(3), SPP1(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(4), TNN(3), TNR(8), TNXB(1), VTN(1), VWF(5)	150895233	267	193	265	100	30	38	30	110	59	0	0.936	1.000	1.000
466	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD44(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), FN1(4), FNDC1(1), FNDC3A(2), HMMR(1), HSPG2(8), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), RELN(3), SDC3(1), SPP1(2), SV2C(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(4), TNN(3), TNR(8), TNXB(1), VTN(1), VWF(5)	136421267	225	173	225	85	26	32	27	91	49	0	0.939	1.000	1.000
467	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(2), CHRM2(2), CHRM3(2), CHRM5(2), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2(3), F2RL1(1), F2RL2(1), FPR1(1), GABBR1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(4), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA2(1), GLRB(1), GPR35(1), GPR50(1), GPR63(1), GPR83(1), GRIA1(4), GRIA2(3), GRIA4(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRIN3B(2), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM6(1), GRM7(1), GRM8(2), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), LEP(1), LEPR(1), MAS1(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(2), P2RX1(2), P2RX2(3), P2RX3(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY8(2), PARD3(2), PRLR(2), PRSS3(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), THRA(2), TRHR(2), VIPR1(1)	133299208	228	172	228	73	35	38	20	103	32	0	0.434	1.000	1.000
468	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ADRA1A(1), ADRB2(2), ANXA6(1), ATP1A4(3), ATP2A2(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1S(7), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM2(2), CHRM3(2), CHRM5(2), GJA4(1), GJA5(3), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MYCBP(1), PKIA(1), PLCB3(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RYR1(11), RYR2(9), RYR3(10), SLC8A1(1), SLC8A3(3), USP5(1)	118094932	197	153	197	54	29	23	17	90	38	0	0.269	1.000	1.000
469	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(2), CXCL11(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(7), FAS(1), FASLG(1), FLT1(4), FLT3(2), FLT4(6), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1R1(1), IL1RAP(4), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(2), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(3), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF14(1), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(3), XCL1(2), XCR1(1)	108952487	186	150	184	46	11	32	23	98	22	0	0.137	1.000	1.000
470	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(3), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(3), KRAS(1), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(3), MAGI3(4), MLLT4(5), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH11(6), MYH13(4), MYH14(3), MYH15(2), MYH2(7), MYH3(5), MYH4(6), MYH6(3), MYH7(2), MYH7B(4), MYH8(1), MYH9(2), MYL2(1), MYL7(1), MYL9(1), PARD3(2), PARD6B(3), PPM1J(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), SPTAN1(5), SRC(2), TJAP1(1), TJP1(2), TJP2(2), YES1(1), ZAK(1)	119898906	189	147	189	68	19	22	14	83	50	1	0.959	1.000	1.000
471	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(3), ABLIM3(2), CDC42(1), CFL1(1), CXCR4(1), DCC(3), DPYSL2(2), EFNA3(1), EPHA1(3), EPHA3(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(4), LIMK2(2), MAPK3(1), MET(3), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NRP1(1), NTN4(2), NTNG1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(2), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(5), RND1(3), ROBO1(2), ROBO2(4), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6C(1), SEMA6D(2), SLIT1(1), SLIT2(3), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(2), UNC5C(1), UNC5D(2)	119700033	181	144	179	65	17	27	18	86	33	0	0.918	1.000	1.000
472	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ATF1(2), ATF2(1), ATF4(1), ATF5(1), ATP2A2(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), DGKZ(2), GABPA(1), GBA2(4), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(8), NOS3(2), PDE4B(2), PDE4D(1), PKIA(1), PLCB3(1), PLCG2(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RLN1(1), RYR1(11), RYR2(9), RYR3(10), SLC8A1(1), TNXB(1), USP5(1)	106310346	170	142	170	50	23	24	16	80	27	0	0.545	1.000	1.000
473	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(6), APC2(4), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(2), CREBBP(4), CSNK1A1(1), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(1), DAAM1(2), DKK2(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), JUN(2), LEF1(1), LRP5(2), LRP6(2), MAP3K7(1), MAPK10(1), MAPK9(2), MYC(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SFRP4(2), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), VANGL1(1), VANGL2(1), WIF1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	97175053	157	130	155	53	12	14	25	79	27	0	0.844	1.000	1.000
474	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(4), ACACB(3), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CALM2(1), CBL(1), CBLB(2), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FBP1(1), FOXO1(2), G6PC(2), GRB2(1), GYS1(1), GYS2(1), HRAS(1), INPP5D(1), INSR(3), IRS1(3), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(1), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(2), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPN1(1), PTPRF(3), PYGB(2), PYGL(1), PYGM(2), RAPGEF1(2), RHOQ(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC3(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(4)	95972254	154	128	153	30	14	24	18	77	21	0	0.0178	1.000	1.000
475	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(3), AKT3(2), CBL(1), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(4), CSF2RA(3), CSF2RB(1), CSF3R(2), EP300(6), GH2(1), GHR(1), GRB2(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(2), PIAS2(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS4(1), SOS1(6), SOS2(1), SPRED1(5), SPRED2(1), SPRY2(2), SPRY4(2), STAM(2), STAT1(4), STAT2(3), STAT3(1), STAT4(1), STAT5B(1), STAT6(2), TPO(3), TYK2(3)	88105275	155	126	154	46	8	27	25	77	18	0	0.481	1.000	1.000
476	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM3(1), CD22(1), CD28(1), CD34(1), CD4(2), CD6(2), CD86(1), CD99(1), CDH1(2), CDH2(5), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(5), CNTNAP2(4), ESAM(1), F11R(1), GLG1(4), HLA-C(2), HLA-DPA1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB5(2), HLA-E(2), HLA-F(1), ITGA4(1), ITGA6(4), ITGA9(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(4), MPZL1(1), NCAM1(1), NCAM2(2), NEGR1(2), NEO1(2), NFASC(4), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(3), PTPRC(6), PTPRF(3), PTPRM(3), PVRL2(2), PVRL3(2), SDC3(1), SELE(4), SELP(1), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(6)	88453477	147	122	147	62	11	21	22	72	21	0	0.971	1.000	1.000
477	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(2), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(3), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PFAS(1), PKM2(1), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(2)	101616272	143	121	142	32	10	20	15	66	32	0	0.151	1.000	1.000
478	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ATF4(1), CACNA1C(8), CACNA1D(4), CACNA1F(3), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), EGFR(7), ELK1(1), GNAS(4), GRB2(1), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), KRAS(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MMP14(1), MMP2(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLD1(2), PLD2(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCD(2), PTK2B(2), SOS1(6), SOS2(1), SRC(2)	80046947	144	116	143	40	18	20	14	74	18	0	0.347	1.000	1.000
479	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(4), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), EGFR(7), EP300(6), ERBB2(4), FARP2(2), FGFR1(4), FYN(1), INSR(3), IQGAP1(5), LEF1(1), LMO7(4), MAP3K7(1), MAPK3(1), MET(3), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(3), PTPRJ(4), PTPRM(3), PVRL2(2), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(1), WASF3(1), WASL(6), YES1(1)	74430827	136	112	135	39	11	15	24	65	21	0	0.505	1.000	1.000
480	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), DRD1(1), DRD2(1), EGF(4), EGFR(7), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(1), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), NPR1(3), NPR2(2), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(2), SOS1(6), SOS2(1), SRC(2), TJP1(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1)	81467808	140	112	138	38	15	19	15	68	23	0	0.372	1.000	1.000
481	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), ATM(15), ATR(5), BUB3(1), CCNA1(3), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDC14A(3), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(2), CDC7(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(3), E2F1(1), EP300(6), ESPL1(7), FZR1(4), HDAC1(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(5), RB1(1), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), WEE1(1), YWHAE(1)	84463184	141	110	141	36	7	21	20	62	31	0	0.289	1.000	1.000
482	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN11(1), CAPN3(3), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(1), CSK(2), DOCK1(1), FYN(1), GIT2(1), GRB2(1), ILK(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K3(3), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), RAC1(1), RAC3(1), RAPGEF1(2), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(2), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(4), TNS1(5), VAV2(4), VCL(2), ZYX(1)	83668064	128	109	128	45	9	22	19	60	18	0	0.782	1.000	1.000
483	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(3), ASH2L(2), CTCFL(1), DOT1L(2), EHMT1(1), EHMT2(3), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(2), JMJD4(1), JMJD6(4), KDM6A(4), MEN1(1), MLL(5), MLL2(13), MLL3(15), MLL4(3), MLL5(6), NSD1(4), OGT(4), PRDM2(1), PRDM6(1), PRDM7(2), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), RBBP5(3), SETD1A(2), SETD1B(1), SETDB1(4), SETMAR(1), SUV39H2(3), SUZ12(5), WHSC1(2), WHSC1L1(5)	72362582	121	108	121	37	7	15	18	42	39	0	0.651	1.000	1.000
484	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(3), ACTN3(1), ACTN4(1), DMD(5), FAM48A(1), MYBPC1(1), MYBPC2(3), MYBPC3(1), MYH3(5), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL2(1), MYL9(1), MYOM1(3), NEB(11), TMOD1(2), TNNI1(1), TNNT1(2), TNNT3(1), TPM2(1), TTN(75)	87431342	126	107	126	35	12	22	10	57	23	2	0.427	1.000	1.000
485	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(2), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE6B(2), PDE6C(2), PDE8A(2), PFAS(1), PKM2(1), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1)	79097280	121	105	121	24	13	14	12	57	25	0	0.0778	1.000	1.000
486	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR6(1), CCR9(1), CHML(1), CHRM2(2), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2RL1(1), F2RL2(1), FPR1(1), GALR1(1), GALT(2), GPR17(1), GPR173(2), GPR174(2), GPR35(1), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(1), GPR85(2), HCRTR2(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(2), OPRM1(2), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(1), OR8B8(2), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2)	71443225	119	104	119	36	22	13	15	54	15	0	0.318	1.000	1.000
487	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ARHGAP5(4), BCAR1(3), CD99(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(4), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), VAV1(2), VAV2(4), VCAM1(1), VCL(2)	75500430	125	103	124	48	10	19	13	54	29	0	0.913	1.000	1.000
488	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), AKAP1(2), AKAP11(1), AKAP12(3), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(11), ARHGEF1(1), CALM2(1), CHMP1B(2), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKD3(2), SLC9A1(2), USP5(1)	72519872	123	100	123	30	12	17	5	65	24	0	0.283	1.000	1.000
489	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(5), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(1), GRIA1(4), GRIA2(3), GRID2(4), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(3), NPR2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCG(1), PRKG1(2), PRKG2(2), RYR1(11)	68427272	115	100	115	43	17	13	11	55	19	0	0.883	1.000	1.000
490	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), ENPP3(1), EP400(5), ERCC2(1), ERCC3(1), G6PC(2), GAA(1), GANC(1), GBA(2), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), IFIH1(2), MGAM(2), MOV10L1(3), PYGB(2), PYGL(1), PYGM(2), RAD54L(2), RUVBL2(2), SETX(5), SI(6), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), UXS1(1)	77200858	117	95	115	37	5	20	21	43	28	0	0.607	1.000	1.000
491	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(4), ABCA12(7), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(5), ABCA5(6), ABCA6(1), ABCA7(6), ABCA8(3), ABCA9(2), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(3), ABCB6(1), ABCC1(2), ABCC10(3), ABCC11(1), ABCC12(3), ABCC2(1), ABCC3(7), ABCC4(3), ABCC5(4), ABCC6(4), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(3), ABCG5(1), ABCG8(2), CFTR(4)	72984357	119	94	118	36	6	20	17	60	15	1	0.468	1.000	1.000
492	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	BID(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), FYN(1), GRB2(1), HLA-C(2), HLA-E(2), HRAS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), ITGAL(4), ITGB2(1), KIR3DL1(1), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK1(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SYK(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(4)	67507057	106	93	103	43	5	20	16	53	12	0	0.952	1.000	1.000
493	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(1), ALG8(2), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT3(1), B4GALT4(2), B4GALT5(1), CHST1(1), CHST11(1), CHST12(1), CHST4(1), CHST7(1), CHSY1(2), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST5(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST2(2), NDST4(3), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2)	66116349	105	91	105	34	4	20	14	46	21	0	0.718	1.000	1.000
494	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(4), ACVR1C(1), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(3), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), MYC(1), PITX2(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMAD9(1), SMURF2(3), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(6), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(4)	60246080	105	91	104	28	5	10	14	54	22	0	0.532	1.000	1.000
495	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(4), CBL(1), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(1), FYN(1), GRAP2(1), GRB2(1), HRAS(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIB(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(3), PTPN6(3), PTPRC(6), SOS1(6), SOS2(1), TEC(5), VAV1(2), VAV2(4)	60656340	108	91	106	27	4	19	13	60	12	0	0.369	1.000	1.000
496	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(1), ARHGEF7(3), BCAR1(3), BRAF(1), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(1), FYN(1), GRB2(1), GRB7(2), GRLF1(6), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CB(1), PLCG2(1), PTK2(1), RHO(1), ROCK1(4), ROCK2(3), SHC1(2), SOS1(6), SOS2(1), SRC(2), TLN1(4), TLN2(6), ZYX(1)	73715100	115	91	115	38	8	25	13	51	18	0	0.664	1.000	1.000
497	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(4), ABL2(2), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), ERBB3(3), ERBB4(6), GAB1(1), GRB2(1), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NRG1(4), NRG2(2), NRG3(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SRC(2), STAT5B(1)	61756298	107	90	105	29	9	23	12	53	10	0	0.285	1.000	1.000
498	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(1), CREBBP(4), CTNNB1(1), DCT(4), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), TCF7L2(1), TYR(3), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	65676689	104	90	104	28	9	10	13	56	16	0	0.421	1.000	1.000
499	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(6), ATF4(1), BRAF(1), CACNA1C(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(4), EP300(6), GRIA1(4), GRIA2(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRM1(4), GRM5(4), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAP1A(1), RAPGEF3(2), RPS6KA1(2), RPS6KA6(1)	62722718	102	89	102	23	13	14	10	53	12	0	0.105	1.000	1.000
500	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(4), AKT1(2), AURKB(1), BMPR2(4), CDS2(1), CLK1(4), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A2(1), CSNK2B(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PAK4(2), PIK3C2B(3), PIK3C2G(2), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1), PLK3(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKG1(2), RPS6KA1(2), RPS6KB1(1), STK11(1)	69166442	100	88	99	30	8	19	5	47	21	0	0.574	1.000	1.000
501	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(4), ATM(15), BUB3(1), CCNA1(3), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDAN1(3), CDC14A(3), CDC20(1), CDC25A(1), CDC25C(2), CDC7(1), CDH1(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK2(1), E2F1(1), E2F5(1), EP300(6), ESPL1(7), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(5), PTPRA(1), RB1(1), SKP2(1), SMAD4(1), TBC1D8(1), WEE1(1)	68397250	106	86	106	34	6	18	20	45	17	0	0.517	1.000	1.000
502	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM2(1), CDS2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), OCRL(1), PI4KA(8), PI4KB(1), PIK3C2B(3), PIK3C2G(2), PIK3C3(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PRKCG(1), PTPMT1(1), SYNJ1(4), SYNJ2(5)	76112879	98	86	95	35	8	17	9	44	20	0	0.800	1.000	1.000
503	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	CABIN1(5), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(1), EGR3(1), EP300(6), GATA4(1), GRLF1(6), GSK3A(2), HRAS(1), IFNA1(2), IFNB1(2), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKBIB(1), NPPB(1), NUP214(2), OPRD1(2), PAK1(1), PPP3CC(1), PTPRC(6), RELA(1), SP3(1), TRPV6(4), VAV1(2), VAV2(4), XPO5(2)	55354822	96	84	95	26	8	15	13	47	13	0	0.348	1.000	1.000
504	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK2(2), CLK4(2), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(2), CPSF4(2), CSTF2T(1), CSTF3(3), DDX1(1), DDX20(4), DHX15(3), DHX8(1), DHX9(3), DICER1(2), FUS(4), LSM7(1), METTL3(4), NONO(2), NXF1(1), PAPOLA(3), POLR2A(6), PRPF3(1), PRPF4B(1), PRPF8(7), PSKH1(2), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(1), SNRPN(2), SRPK2(2), SRRM1(1), SUPT5H(5), TXNL4A(1), U2AF2(1), XRN2(3)	65315822	101	84	101	28	4	25	10	44	17	1	0.371	1.000	1.000
505	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(6), CD19(1), CD1D(3), CD1E(1), CD22(1), CD24(1), CD33(1), CD34(1), CD38(1), CD3E(2), CD3G(1), CD4(2), CD44(1), CD55(1), CR1(7), CR2(1), CSF1R(5), CSF2RA(3), CSF3R(2), DNTT(2), FLT3(2), GYPA(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL9R(2), ITGA1(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(3), ITGB3(1), KIT(3), KITLG(2), MME(3), TPO(3)	50449603	85	75	85	22	5	9	16	42	13	0	0.438	1.000	1.000
506	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(2), CHUK(1), CPT1A(1), G6PC(2), IRS1(3), IRS4(1), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), PPARGC1A(3), PRKAG1(1), PRKAG2(4), PRKCQ(3), PTPN11(1), RELA(1), RXRB(3), RXRG(2), SLC2A4(1), STAT3(1), STK11(1), TNFRSF1A(1), TRADD(1), TYK2(3)	49830098	79	72	79	22	3	15	12	34	15	0	0.443	1.000	1.000
507	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(3), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), MET(3), MYC(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARD3(2), PDK1(1), PPP1R13B(3), PREX1(6), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(6), SOS2(1), TSC1(2), TSC2(4), YWHAE(1)	44559976	76	68	76	21	6	12	7	39	12	0	0.543	1.000	1.000
508	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(3), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(1)	50635943	74	67	73	18	2	14	13	28	17	0	0.150	1.000	1.000
509	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(4), CD19(1), CD22(1), CHUK(1), CR2(1), HRAS(1), INPP5D(1), JUN(2), KRAS(1), LILRB3(3), MALT1(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIB(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(4)	44212145	72	66	70	20	2	14	8	38	10	0	0.476	1.000	1.000
510	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(15), CCNA1(3), CCND2(1), CCNE1(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(1), E2F1(1), E2F5(1), GBA2(4), MCM2(3), MCM5(1), MCM6(2), MCM7(4), MYC(1), MYT1(2), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(1), RPA2(1), RPA3(1), TFDP2(5), TNXB(1), WEE1(1)	45649123	76	64	76	23	3	10	10	36	17	0	0.659	1.000	1.000
511	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(1), GAB2(1), GRB2(1), HRAS(1), IL3(1), IL4(1), INPP5D(1), KRAS(1), LCP2(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCD(2), PRKCE(2), RAC1(1), RAC3(1), SOS1(6), SOS2(1), SYK(1), VAV1(2), VAV2(4)	43332918	67	63	66	26	7	13	9	33	5	0	0.800	1.000	1.000
512	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(1), CPT1A(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FADS2(2), GK2(1), HMGCS2(1), ILK(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(1), RXRB(3), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(1), UBC(2), UCP1(1)	39806181	69	62	69	21	5	10	11	31	12	0	0.585	1.000	1.000
513	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(1), BMP6(1), BMP7(2), BTRC(2), CSNK1A1(1), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(4), GLI3(3), HHIP(2), LRP2(13), PRKACA(1), PRKACB(4), PRKACG(2), PTCH1(7), PTCH2(1), SHH(1), SMO(3), STK36(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	35583288	67	60	65	21	6	8	7	39	7	0	0.736	1.000	1.000
514	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(2), AKT2(3), AKT3(2), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCG(1), PTGS2(4), PTK2(1), RAC1(1), RAC3(1), SHC2(1), SPHK2(1), SRC(2)	42678338	67	60	65	30	4	12	8	36	7	0	0.942	1.000	1.000
515	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(1), PI4KA(8), PI4KB(1), PIK3C3(1), PIK3CB(1), PIK3CG(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PTPMT1(1), SYNJ1(4), SYNJ2(5)	43954320	63	59	62	21	4	9	6	27	17	0	0.817	1.000	1.000
516	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), EP400(5), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(5), SMARCA2(4), SMARCA5(1)	38574277	66	58	66	17	1	18	10	21	16	0	0.227	1.000	1.000
517	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(2), DVL1(1), EP300(6), HDAC1(2), JAG1(1), JAG2(2), MAML1(4), MAML2(2), MAML3(5), NCOR2(4), NCSTN(1), NOTCH1(3), NOTCH2(7), NOTCH3(6), NOTCH4(1), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1)	40444145	67	57	67	24	5	7	13	30	12	0	0.763	1.000	1.000
518	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(1), CREBBP(4), EHHADH(2), EP300(6), FABP1(1), HSD17B4(1), JUN(2), LPL(1), MAPK3(1), ME1(1), MYC(1), NCOA1(2), NCOR1(3), NCOR2(4), NR1H3(1), NRIP1(6), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTGS2(4), RB1(1), RELA(1), SRA1(1), STAT5B(1)	37203229	56	53	56	16	4	11	9	30	2	0	0.348	1.000	1.000
519	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(1), CR2(1), CSK(2), GRB2(1), GSK3A(2), INPP5D(1), ITPR1(2), ITPR2(8), ITPR3(3), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3R1(2), PLCG2(1), PPP1R13B(3), PPP3CA(1), PPP3CC(1), PTPRC(6), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2)	43801019	62	53	62	16	6	13	6	28	9	0	0.202	1.000	1.000
520	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1A2(1), EEF1D(1), EEF1G(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(9), PABPC3(6), PAIP1(2), SLC35A4(2)	27332007	58	53	58	19	7	11	9	21	10	0	0.582	1.000	1.000
521	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(4), ATP4A(3), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), PPA2(2), SDHB(1), SDHD(1), UQCRC2(1)	34655460	54	52	54	22	4	6	8	26	10	0	0.941	1.000	1.000
522	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), CDC42(1), CHUK(1), CSK(2), EGFR(7), F11R(1), GIT1(2), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(3), NFKB1(1), NOD1(1), PAK1(1), PLCG2(1), PTPN11(1), PTPRZ1(8), RAC1(1), RELA(1), SRC(2), TJP1(2)	43767104	61	51	60	20	3	11	9	30	8	0	0.775	1.000	1.000
523	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(6), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), FZD1(2), FZD10(2), FZD3(1), FZD5(1), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1)	35605677	55	51	55	22	5	11	6	26	7	0	0.817	1.000	1.000
524	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CFLAR(1), CHUK(1), DAXX(4), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(4), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(1), PRKCD(2), PRKDC(5), PSEN2(3), PTK2(1), RASA1(3), RB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1)	42948439	57	50	57	19	2	15	7	25	8	0	0.652	1.000	1.000
525	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(4), EGF(4), EGFR(7), HRAS(1), JUN(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), RELA(1), RIPK1(1), TNFRSF1A(1)	30112622	52	50	51	17	5	5	3	25	14	0	0.812	1.000	1.000
526	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), DDC(2), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), TPH1(1), TPH2(1), WARS2(1)	37332426	56	49	56	16	4	11	9	25	7	0	0.505	1.000	1.000
527	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT2(2), B3GALT4(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), B4GALT6(1), FUT1(1), FUT6(1), GBGT1(2), GCNT2(4), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(1), ST8SIA1(2), ST8SIA5(1)	29538729	51	48	51	17	5	8	8	19	10	1	0.670	1.000	1.000
528	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(2), AOC3(1), ARG1(1), ASL(1), CPS1(5), DAO(1), GATM(2), GOT1(2), GOT2(2), MAOA(1), NOS1(8), NOS3(2), ODC1(1), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2)	27134161	52	47	52	19	2	4	13	24	9	0	0.805	1.000	1.000
529	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(2), CDC27(2), CUL1(3), CUL2(1), CUL3(5), FBXW11(1), FBXW7(1), FZR1(4), SKP2(1), SMURF2(3), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D3(1), UBE2E2(1), WWP2(2)	24992736	46	46	44	13	2	5	5	22	12	0	0.743	1.000	1.000
530	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	31677284	52	46	52	23	3	12	9	22	6	0	0.917	1.000	1.000
531	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	31677284	52	46	52	23	3	12	9	22	6	0	0.917	1.000	1.000
532	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(4), CARS2(2), DARS(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), KARS(1), LARS(1), LARS2(1), MARS(2), MARS2(3), NARS2(4), PARS2(2), SARS(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS2(1), YARS(1)	32597040	47	45	47	13	1	9	6	25	6	0	0.457	1.000	1.000
533	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(2), GAA(1), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), MGAM(2), PYGB(2), PYGL(1), PYGM(2), RNPC3(1), SI(6), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1)	35652492	52	45	50	15	4	6	11	19	12	0	0.494	1.000	1.000
534	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1C1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTM1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	35849687	50	44	49	17	5	6	7	21	11	0	0.766	1.000	1.000
535	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(2), FYN(1), GRB2(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAPK3(1), PTK2(1), RAP1A(1), ROCK1(4), SHC1(2), SOS1(6), SRC(2), TLN1(4), VCL(2), ZYX(1)	28961613	48	44	48	15	5	8	2	24	9	0	0.737	1.000	1.000
536	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CSK(2), EPHB2(1), FBXW7(1), GRAP2(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(1), LCP2(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PTPRC(6), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(1), VAV1(2)	34244885	50	44	49	17	6	9	4	25	6	0	0.735	1.000	1.000
537	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLD1(3), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBC(2)	31494222	47	43	47	17	3	6	6	22	10	0	0.785	1.000	1.000
538	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(2), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(2), HADHA(1), MAOA(1), TPH1(1), WARS2(1)	33897692	51	43	51	19	4	10	6	26	5	0	0.776	1.000	1.000
539	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GAPDHS(1), GOT1(2), GOT2(2), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TNFAIP1(1), TPI1(1)	26101135	47	42	47	15	2	4	6	17	18	0	0.748	1.000	1.000
540	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT6(1), CDS2(1), CHKB(1), CHPT1(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(1), LCAT(1), LYPLA1(1), MYST3(4), MYST4(4), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(1)	40535957	47	42	47	11	6	5	9	22	5	0	0.239	1.000	1.000
541	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(2), ASAH1(1), ATF1(2), BRAF(1), CREBBP(4), EGR1(2), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(3), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(4), PIK3C2G(2), PIK3R1(2), PTPN11(1), SHC1(2), SRC(2), TH(1)	30087867	45	42	45	15	6	9	3	20	7	0	0.618	1.000	1.000
542	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), CD3E(2), CD3G(1), ELK1(1), FYN(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), PIK3R1(2), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RASA1(3), RELA(1), SHC1(2), SOS1(6), SYT1(1), VAV1(2)	27569795	45	42	45	16	5	11	5	19	5	0	0.704	1.000	1.000
543	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1)	30105215	47	41	46	17	4	2	5	22	14	0	0.905	1.000	1.000
544	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1)	30105215	47	41	46	17	4	2	5	22	14	0	0.905	1.000	1.000
545	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(3), ACADM(1), ACSS1(3), ACSS2(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(2), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1)	24582680	42	41	42	13	2	5	12	14	9	0	0.590	1.000	1.000
546	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR6(1), CXCR4(1), CXCR6(1), EDNRB(1), FPR1(1), GALR1(1), GALT(2), GPR77(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(2), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2)	31235819	46	40	46	16	11	5	5	20	5	0	0.517	1.000	1.000
547	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CREBBP(4), EP300(6), ERCC3(1), GTF2A1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(4), NRIP1(6), PELP1(1), POLR2A(6), SRA1(1), TBP(1)	28772970	43	39	43	14	0	7	10	20	6	0	0.529	1.000	1.000
548	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(1), ASS1(2), CPS1(5), DAO(1), EPRS(2), GATM(2), GOT1(2), GOT2(2), LAP3(2), NOS1(8), NOS3(2), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(2), PRODH(1), PYCR1(1), PYCR2(1)	22160264	41	39	41	15	2	3	11	18	7	0	0.762	1.000	1.000
549	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	20081807	41	39	41	15	1	6	8	20	6	0	0.845	1.000	1.000
550	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(2), GPX4(1), GPX6(1), LTA4H(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1)	24062020	42	39	41	15	5	5	10	16	6	0	0.625	1.000	1.000
551	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	BID(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), CHUK(1), FAS(1), FASLG(1), HELLS(2), JUN(2), LTA(1), MAP3K1(4), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP73(3), TRADD(1), TRAF3(1)	34112386	38	38	38	14	0	7	5	18	8	0	0.812	1.000	1.000
552	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(4), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PIK3R1(2), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2)	24592633	38	37	38	16	5	7	4	17	5	0	0.849	1.000	1.000
553	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), CBL(1), CFLAR(1), E2F1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(3), MAPK3(1), MYC(1), PIK3R1(2), PTPN6(3), RPS6KB1(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1)	20429438	38	37	38	13	4	8	4	15	7	0	0.622	1.000	1.000
554	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), ATP7A(1), ATP7B(5), COX6A2(1), COX7A2(1), NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1), PPA2(2), SDHB(1), SHMT1(2)	23852880	37	37	37	15	1	7	6	17	6	0	0.874	1.000	1.000
555	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GLB1(4), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PPAP2B(1), PPAP2C(2)	29842836	39	36	38	14	5	8	4	15	7	0	0.728	1.000	1.000
556	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(1), ALG6(1), ALG8(2), B4GALT3(1), DOLPP1(2), DPAGT1(2), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), RPN2(1), STT3B(2)	25918113	37	36	37	12	0	8	1	18	10	0	0.765	1.000	1.000
557	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	DOCK1(1), ELK1(1), GAB1(1), GRB2(1), HGF(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAP4K1(1), MAPK3(1), MET(3), PAK1(1), PIK3R1(2), PTK2(1), PTK2B(2), PTPN11(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(1)	26045794	39	36	39	17	2	12	2	17	6	0	0.935	1.000	1.000
558	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(4), DIAPH1(1), FYN(1), GSN(1), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PIK3R1(2), PTK2(1), ROCK1(4), SHC1(2), SRC(2), TLN1(4)	21704849	35	35	35	13	4	7	2	15	7	0	0.836	1.000	1.000
559	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), ARG1(1), ASL(1), ASS1(2), CPS1(5), GATM(2), MAOA(1), ODC1(1), OTC(1), SAT1(1), SAT2(1), SMS(2)	18081719	35	34	35	13	0	5	8	18	4	0	0.822	1.000	1.000
560	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(1), ESR2(1), NR1D2(1), NR1H3(1), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(1), NR4A2(1), NR5A2(2), PGR(1), PPARD(1), PPARG(1), RARA(4), RARB(2), RORA(1), RXRB(3), RXRG(2), THRA(2), VDR(1)	24907020	36	34	36	12	3	3	11	12	7	0	0.695	1.000	1.000
561	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1)	22738541	38	34	38	12	0	5	7	14	12	0	0.719	1.000	1.000
562	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK14(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), RAC1(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2)	23043913	36	33	36	19	5	6	4	16	5	0	0.967	1.000	1.000
563	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(3), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(9), PDK2(1), PIK3R1(2), RPS6KB1(1)	15370974	34	33	34	13	4	8	4	16	2	0	0.721	1.000	1.000
564	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), ELK1(1), FPR1(1), GNA15(1), GNB1(2), HRAS(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(1), SYT1(1)	23572453	38	33	38	12	5	5	3	17	8	0	0.659	1.000	1.000
565	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), CALM2(1), ELK1(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1)	20771360	34	33	34	13	5	4	2	19	4	0	0.861	1.000	1.000
566	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(4), CLYBL(2), CS(1), DLD(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), OGDHL(2), PC(1), PCK1(4), PCK2(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1)	18584106	36	33	36	13	3	5	3	18	7	0	0.803	1.000	1.000
567	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), FLT1(4), FLT4(6), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3R1(2), PTK2(1), SHC1(2)	19545727	34	33	34	14	5	4	4	15	6	0	0.897	1.000	1.000
568	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GHR(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JAK2(5), MAPK3(1), PIK3R1(2), PTPN6(3), RPS6KA1(2), SHC1(2), SLC2A4(1), SOS1(6), SRF(1), STAT5B(1)	18774900	33	32	33	13	4	6	5	16	2	0	0.745	1.000	1.000
569	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(1), ECHS1(2), EHHADH(2), GAD2(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), RDH11(3)	25117682	34	32	33	12	5	4	5	14	6	0	0.725	1.000	1.000
570	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1)	20524915	33	32	33	12	2	3	9	13	6	0	0.767	1.000	1.000
571	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), DEGS1(2), ENPP7(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(1), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2)	21162933	32	31	32	11	5	5	5	12	5	0	0.634	1.000	1.000
572	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), GRB2(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), SHC1(2), SOS1(6), SRF(1), STAT3(1)	14453573	32	31	32	12	2	4	5	17	4	0	0.860	1.000	1.000
573	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(3), MAP3K1(4), MAPK14(1), MAPK3(1), PAK1(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1)	17464944	32	30	32	13	4	7	1	16	4	0	0.870	1.000	1.000
574	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RASAL1(1), SRC(2), TEC(5), VAV1(2)	16974757	30	29	29	12	2	3	5	15	5	0	0.890	1.000	1.000
575	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), STAT1(4), STAT3(1), STAT5B(1)	17063047	29	29	29	11	3	5	2	17	2	0	0.822	1.000	1.000
576	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), FAS(1), FASLG(1), JUN(2), MAP3K1(4), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(2), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TRADD(1)	22139733	28	28	28	14	0	7	5	11	5	0	0.954	1.000	1.000
577	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), AKT1(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(1), PIK3C2G(2), PIK3R1(2)	29001960	32	28	32	12	4	6	3	15	4	0	0.642	1.000	1.000
578	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDS2(1), CHKB(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG2(1), PPAP2B(1), PPAP2C(2)	30852637	29	27	29	12	5	6	3	11	4	0	0.745	1.000	1.000
579	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(3), ITGB1(3), ITGB3(1), PTK2(1), RAC1(1), SPTAN1(5), SRC(2), TLN1(4)	17808646	27	27	27	11	3	4	1	12	7	0	0.932	1.000	1.000
580	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(3), ADCY9(3), ARF1(1), ARF3(1), ARF6(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ERO1L(1), GNAS(4), PLCG2(1), SEC61B(1), TRIM23(2)	22897173	27	26	27	15	1	3	4	14	5	0	0.993	1.000	1.000
581	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(1), PIK3C2B(3), PIK3C2G(2), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1)	26567356	30	26	29	16	2	3	1	16	8	0	0.994	1.000	1.000
582	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(1), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3R1(2), PLCB1(1), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2)	15601544	26	25	26	14	1	5	2	12	6	0	0.977	1.000	1.000
583	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMPPB(1), HK1(4), KHK(4), MPI(1), PFKFB3(1), PFKM(2), PMM1(1), SORD(2), TPI1(1)	14906325	26	25	26	11	3	2	4	9	8	0	0.875	1.000	1.000
584	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLAT(2), DLD(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1)	17658030	28	25	28	11	1	3	4	15	5	0	0.833	1.000	1.000
585	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), EGFR(7), MYC(1), POLR2A(6), PPP2CA(1), RB1(1), TEP1(2), TERT(4), TNKS(1), XRCC5(2)	16845003	27	25	26	11	3	7	5	9	3	0	0.637	1.000	1.000
586	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	ELK1(1), GRB2(1), HRAS(1), IRS1(3), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SOS1(6), SRF(1)	13546031	24	24	24	11	3	8	1	11	1	0	0.827	1.000	1.000
587	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A3(2)	16050674	25	24	25	10	3	10	1	8	3	0	0.692	1.000	1.000
588	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(2), PFKM(2)	19923975	25	23	25	10	2	2	4	10	7	0	0.868	1.000	1.000
589	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA1(1), JAK1(4), JAK2(5), JAK3(3), STAT1(4), STAT3(1), STAT5B(1), TYK2(3)	11362682	23	23	23	12	1	0	4	14	4	0	0.980	1.000	1.000
590	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), REN(1)	16040168	23	21	23	10	3	9	1	6	4	0	0.786	1.000	1.000
591	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(4), CTNNB1(1), PTK2(1), SRC(2), VCL(2)	11855282	22	21	22	12	4	4	1	10	3	0	0.966	1.000	1.000
592	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), PLA2G4A(1), PLCB1(1), PTGS1(1), PTK2(1), SRC(2), SYK(1), TBXAS1(1)	15086673	22	21	22	13	2	3	3	7	7	0	0.979	1.000	1.000
593	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), PTGS1(1), PTGS2(4), TBXAS1(1)	12538726	20	20	20	12	1	3	3	8	5	0	0.971	1.000	1.000
594	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(6), ASAH1(1), EPHB2(1), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	17169842	20	20	20	10	4	2	3	10	1	0	0.867	1.000	1.000
595	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	DPM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3R1(2), SHC1(2), SOS1(6)	10137276	19	19	19	7	2	5	1	11	0	0	0.758	1.000	1.000
596	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2)	11232717	19	18	19	10	1	0	5	10	3	0	0.978	1.000	1.000
597	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), GRB2(1), HRAS(1), IRS1(3), MAPK3(1), PIK3R1(2), SHC1(2), SOS1(6)	10055390	18	18	18	8	3	5	1	9	0	0	0.757	1.000	1.000
598	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(2), PLCB1(1), PTK2(1), ROCK2(3)	15794685	19	17	19	11	1	2	0	12	4	0	0.993	1.000	1.000
599	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4)	9070518	17	17	17	11	0	1	6	6	4	0	0.993	1.000	1.000
600	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3R1(2), PTK2(1), PTK2B(2), RELA(1)	15976816	18	16	18	15	1	5	1	9	2	0	0.997	1.000	1.000
601	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PPAP2B(1), PPAP2C(2)	14415375	17	16	17	9	1	2	4	10	0	0	0.912	1.000	1.000
602	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), SP3(1), SYT1(1)	12257733	14	14	14	11	2	3	2	5	2	0	0.992	1.000	1.000
603	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG2(2), NRG3(2)	5666673	10	10	10	5	1	3	0	6	0	0	0.850	1.000	1.000
604	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2)	6430723	9	9	9	5	2	1	2	4	0	0	0.805	1.000	1.000
605	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CXCR4(1), JUN(2), MAPK14(1), PTK2B(2), SYT1(1)	8428473	9	8	9	7	1	3	1	4	0	0	0.965	1.000	1.000
606	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BID(1), BIRC2(3), BIRC3(2), CASP7(1)	8384011	7	7	7	4	0	2	1	4	0	0	0.862	1.000	1.000
607	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(3)	5132206	4	4	4	3	0	1	0	3	0	0	0.946	1.000	1.000
608	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(1), NR1H4(1)	3221997	3	3	3	3	0	1	0	2	0	0	0.974	1.000	1.000
609	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PTK2B(2)	4134066	3	3	3	6	0	2	0	1	0	0	0.997	1.000	1.000
610	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), SNCAIP(1), UBE2E2(1)	3943564	3	3	3	3	0	2	1	0	0	0	0.906	1.000	1.000
611	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(1), SP3(1)	4177849	2	2	2	2	0	2	0	0	0	0	0.962	1.000	1.000
612	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(1)	3394881	2	2	2	2	1	1	0	0	0	0	0.902	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	993669	1	1	1	2	0	0	1	0	0	0	0.982	1.000	1.000
614	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	1301999	1	1	1	2	0	0	0	1	0	0	0.989	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		316078	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4		3004629	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
