Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	42.0	339.0	8.0	-0.298	0.134	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by the Hedgehog family	36.0	1912.0	52.0	-0.535	0.237	1000.0	-1000.0	-0.079	-1000.0
FOXA2 and FOXA3 transcription factor networks	31.0	1444.0	46.0	-0.759	0.011	1000.0	-1000.0	-0.103	-1000.0
p75(NTR)-mediated signaling	17.0	2181.0	125.0	-0.245	0.011	1000.0	-1000.0	-0.099	-1000.0
Glypican 1 network	17.0	844.0	48.0	-0.291	0.046	1000.0	-1000.0	-0.046	-1000.0
TCGA08_p53	17.0	119.0	7.0	-0.228	0.126	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	17.0	1074.0	60.0	-0.47	0.011	1000.0	-1000.0	-0.158	-1000.0
IL4-mediated signaling events	16.0	1462.0	91.0	-0.755	0.569	1000.0	-1000.0	-0.164	-1000.0
Ephrin B reverse signaling	14.0	703.0	48.0	-0.166	0.091	1000.0	-1000.0	-0.064	-1000.0
Wnt signaling	13.0	95.0	7.0	-0.128	0.0	1000.0	-1000.0	-0.031	-1000.0
Glucocorticoid receptor regulatory network	12.0	1443.0	114.0	-0.564	0.308	1000.0	-1000.0	-0.074	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	832.0	68.0	-0.31	0.14	1000.0	-1000.0	-0.127	-1000.0
BMP receptor signaling	11.0	947.0	81.0	-0.251	0.033	1000.0	-1000.0	-0.09	-1000.0
S1P5 pathway	11.0	198.0	17.0	-0.181	0.119	1000.0	-1000.0	-0.052	-1000.0
Syndecan-1-mediated signaling events	10.0	340.0	34.0	-0.137	0.011	1000.0	-1000.0	-0.06	-1000.0
Ephrin A  reverse signaling	10.0	75.0	7.0	-0.049	0.0	1000.0	-1000.0	-0.033	-1000.0
HIF-1-alpha transcription factor network	10.0	803.0	76.0	-0.321	0.018	1000.0	-1000.0	-0.168	-1000.0
Endothelins	10.0	1010.0	96.0	-0.254	0.012	1000.0	-1000.0	-0.083	-1000.0
LPA receptor mediated events	10.0	1055.0	102.0	-0.173	0.023	1000.0	-1000.0	-0.085	-1000.0
BCR signaling pathway	10.0	1073.0	99.0	-0.167	0.014	1000.0	-1000.0	-0.077	-1000.0
IL12-mediated signaling events	9.0	835.0	87.0	-0.234	0.065	1000.0	-1000.0	-0.13	-1000.0
Visual signal transduction: Cones	9.0	378.0	38.0	-0.174	0.011	1000.0	-1000.0	-0.062	-1000.0
Noncanonical Wnt signaling pathway	9.0	241.0	26.0	-0.128	0.011	1000.0	-1000.0	-0.086	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	883.0	97.0	-0.19	0.025	1000.0	-1000.0	-0.091	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	412.0	44.0	-0.142	0.011	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	9.0	875.0	93.0	-0.16	0.087	1000.0	-1000.0	-0.077	-1000.0
EPHB forward signaling	9.0	832.0	85.0	-0.134	0.104	1000.0	-1000.0	-0.079	-1000.0
EGFR-dependent Endothelin signaling events	9.0	205.0	21.0	-0.13	0.011	1000.0	-1000.0	-0.068	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1188.0	120.0	-0.36	0.143	1000.0	-1000.0	-0.077	-1000.0
Visual signal transduction: Rods	9.0	518.0	52.0	-0.22	0.011	1000.0	-1000.0	-0.077	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	289.0	34.0	-0.085	0.011	1000.0	-1000.0	-0.056	-1000.0
Osteopontin-mediated events	8.0	313.0	38.0	-0.172	0.014	1000.0	-1000.0	-0.092	-1000.0
Thromboxane A2 receptor signaling	8.0	866.0	105.0	-0.13	0.02	1000.0	-1000.0	-0.063	-1000.0
amb2 Integrin signaling	8.0	704.0	82.0	-0.138	0.011	1000.0	-1000.0	-0.073	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	735.0	82.0	-0.117	0.011	1000.0	-1000.0	-0.083	-1000.0
Glypican 2 network	8.0	33.0	4.0	-0.04	-1000.0	1000.0	-1000.0	-0.031	-1000.0
Syndecan-2-mediated signaling events	7.0	538.0	69.0	-0.165	0.03	1000.0	-1000.0	-0.05	-1000.0
Arf6 signaling events	7.0	493.0	62.0	-0.13	0.011	1000.0	-1000.0	-0.071	-1000.0
Effects of Botulinum toxin	7.0	207.0	26.0	-0.105	0.011	1000.0	-1000.0	-0.057	-1000.0
Syndecan-4-mediated signaling events	7.0	535.0	67.0	-0.165	0.015	1000.0	-1000.0	-0.082	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.027	-1000.0	1000.0	-1000.0	-0.013	-1000.0
ErbB4 signaling events	6.0	441.0	69.0	-0.192	0.043	1000.0	-1000.0	-0.082	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	179.0	28.0	-0.181	0.011	1000.0	-1000.0	-0.06	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	414.0	65.0	-0.509	0.038	1000.0	-1000.0	-0.065	-1000.0
EPO signaling pathway	6.0	332.0	55.0	-0.167	0.011	1000.0	-1000.0	-0.092	-1000.0
Reelin signaling pathway	6.0	390.0	56.0	-0.135	0.011	1000.0	-1000.0	-0.08	-1000.0
IL1-mediated signaling events	6.0	384.0	62.0	-0.176	0.054	1000.0	-1000.0	-0.085	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	209.0	31.0	-0.206	0.012	1000.0	-1000.0	-0.09	-1000.0
IGF1 pathway	6.0	388.0	57.0	-0.098	0.019	1000.0	-1000.0	-0.09	-1000.0
Plasma membrane estrogen receptor signaling	6.0	534.0	86.0	-0.095	0.024	1000.0	-1000.0	-0.076	-1000.0
S1P4 pathway	6.0	169.0	25.0	-0.181	0.014	1000.0	-1000.0	-0.055	-1000.0
LPA4-mediated signaling events	5.0	68.0	12.0	-0.063	0.017	1000.0	-1000.0	-0.03	-1000.0
Caspase cascade in apoptosis	5.0	384.0	74.0	-0.074	0.022	1000.0	-1000.0	-0.052	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	309.0	61.0	-0.181	0.036	1000.0	-1000.0	-0.076	-1000.0
Nectin adhesion pathway	5.0	357.0	63.0	-0.078	0.011	1000.0	-1000.0	-0.065	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	293.0	52.0	-0.137	0.013	1000.0	-1000.0	-0.06	-1000.0
S1P1 pathway	5.0	215.0	36.0	-0.082	0.011	1000.0	-1000.0	-0.053	-1000.0
Syndecan-3-mediated signaling events	5.0	182.0	35.0	-0.128	0.011	1000.0	-1000.0	-0.068	-1000.0
Integrins in angiogenesis	5.0	440.0	84.0	-0.176	0.016	1000.0	-1000.0	-0.079	-1000.0
Canonical Wnt signaling pathway	5.0	288.0	51.0	-0.182	0.048	1000.0	-1000.0	-0.063	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	440.0	88.0	-0.129	0.035	1000.0	-1000.0	-0.097	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	180.0	33.0	-0.306	0.032	1000.0	-1000.0	-0.061	-1000.0
FOXM1 transcription factor network	5.0	304.0	51.0	-0.312	0.106	1000.0	-1000.0	-0.18	-1000.0
ErbB2/ErbB3 signaling events	4.0	304.0	65.0	-0.117	0.029	1000.0	-1000.0	-0.064	-1000.0
Coregulation of Androgen receptor activity	4.0	353.0	76.0	-0.365	0.02	1000.0	-1000.0	-0.049	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	240.0	54.0	-0.099	0.023	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by PTP1B	4.0	377.0	76.0	-0.159	0.017	1000.0	-1000.0	-0.073	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	175.0	37.0	-0.169	0.025	1000.0	-1000.0	-0.055	-1000.0
FAS signaling pathway (CD95)	4.0	228.0	47.0	-0.113	0.012	1000.0	-1000.0	-0.046	-1000.0
Retinoic acid receptors-mediated signaling	4.0	281.0	58.0	-0.138	0.011	1000.0	-1000.0	-0.076	-1000.0
Nongenotropic Androgen signaling	4.0	214.0	52.0	-0.055	0.021	1000.0	-1000.0	-0.063	-1000.0
IL27-mediated signaling events	4.0	248.0	51.0	-0.095	0.017	1000.0	-1000.0	-0.065	-1000.0
S1P3 pathway	4.0	186.0	42.0	-0.064	0.012	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	4.0	311.0	70.0	-0.37	0.023	1000.0	-1000.0	-0.061	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	518.0	136.0	-0.282	0.087	1000.0	-1000.0	-0.071	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	54.0	17.0	-0.029	0.026	1000.0	-1000.0	-0.054	-1000.0
Cellular roles of Anthrax toxin	3.0	150.0	39.0	-0.053	0.015	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	276.0	85.0	-0.06	0.029	1000.0	-1000.0	-0.071	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.018	0.021	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	3.0	174.0	58.0	-0.108	0.033	1000.0	-1000.0	-0.08	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	287.0	74.0	-0.161	0.058	1000.0	-1000.0	-0.082	-1000.0
Regulation of Telomerase	3.0	341.0	102.0	-0.131	0.039	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	279.0	78.0	-0.167	0.03	1000.0	-1000.0	-0.08	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.027	0.011	1000.0	-1000.0	-0.043	-1000.0
Circadian rhythm pathway	2.0	46.0	22.0	-0.065	0.033	1000.0	-1000.0	-0.059	-1000.0
IFN-gamma pathway	2.0	198.0	68.0	-0.119	0.032	1000.0	-1000.0	-0.099	-1000.0
Ceramide signaling pathway	2.0	222.0	76.0	-0.13	0.032	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class III	2.0	111.0	40.0	-0.174	0.02	1000.0	-1000.0	-0.041	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	118.0	45.0	-0.062	0.027	1000.0	-1000.0	-0.091	-1000.0
Regulation of p38-alpha and p38-beta	2.0	147.0	54.0	-0.127	0.011	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	2.0	208.0	75.0	-0.08	0.054	1000.0	-1000.0	-0.092	-1000.0
IL2 signaling events mediated by STAT5	2.0	55.0	22.0	-0.054	0.032	1000.0	-1000.0	-0.061	-1000.0
Class I PI3K signaling events	2.0	212.0	73.0	-0.127	0.013	1000.0	-1000.0	-0.065	-1000.0
PDGFR-beta signaling pathway	2.0	257.0	97.0	-0.08	0.046	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by PRL	2.0	90.0	34.0	-0.142	0.023	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling events	2.0	12.0	5.0	-0.016	0.011	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	2.0	102.0	44.0	-0.119	0.015	1000.0	-1000.0	-0.064	-1000.0
Canonical NF-kappaB pathway	1.0	61.0	39.0	-0.053	0.057	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class II	1.0	94.0	75.0	-0.054	0.026	1000.0	-1000.0	-0.062	-1000.0
BARD1 signaling events	1.0	75.0	57.0	-0.016	0.05	1000.0	-1000.0	-0.067	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.011	0.007	1000.0	-1000.0	-0.037	-1000.0
Aurora A signaling	1.0	80.0	60.0	-0.048	0.025	1000.0	-1000.0	-0.053	-1000.0
Arf6 downstream pathway	1.0	83.0	43.0	-0.063	0.028	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	98.0	68.0	-0.051	0.035	1000.0	-1000.0	-0.065	-1000.0
TRAIL signaling pathway	1.0	63.0	48.0	-0.026	0.039	1000.0	-1000.0	-0.063	-1000.0
ceramide signaling pathway	1.0	66.0	49.0	-0.062	0.025	1000.0	-1000.0	-0.046	-1000.0
HIF-2-alpha transcription factor network	1.0	78.0	43.0	-0.057	0.046	1000.0	-1000.0	-0.095	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	152.0	83.0	-0.14	0.041	1000.0	-1000.0	-0.074	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	37.0	36.0	-0.02	0.02	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	231.0	125.0	-0.046	0.055	1000.0	-1000.0	-0.095	-1000.0
TCGA08_rtk_signaling	1.0	43.0	26.0	-0.034	0.036	1000.0	-1000.0	-0.022	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	134.0	76.0	-0.064	0.049	1000.0	-1000.0	-0.077	-1000.0
Insulin Pathway	1.0	136.0	74.0	-0.109	0.033	1000.0	-1000.0	-0.081	-1000.0
VEGFR1 specific signals	1.0	64.0	56.0	-0.019	0.036	1000.0	-1000.0	-0.082	-1000.0
Rapid glucocorticoid signaling	1.0	36.0	20.0	-0.021	0.011	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling in keratinocytes	1.0	79.0	43.0	-0.031	0.034	1000.0	-1000.0	-0.062	-1000.0
Aurora B signaling	1.0	89.0	67.0	-0.109	0.029	1000.0	-1000.0	-0.071	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.004	0.039	1000.0	-1000.0	-0.067	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.006	0.016	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.01	0.011	1000.0	-1000.0	-0.043	-1000.0
PLK1 signaling events	0.0	66.0	85.0	-0.012	0.025	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	0.0	21.0	32.0	-0.051	0.028	1000.0	-1000.0	-0.067	-1000.0
PDGFR-alpha signaling pathway	0.0	39.0	44.0	-0.055	0.033	1000.0	-1000.0	-0.063	-1000.0
mTOR signaling pathway	0.0	13.0	53.0	-0.021	0.021	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class I	0.0	96.0	104.0	-0.081	0.049	1000.0	-1000.0	-0.065	-1000.0
FoxO family signaling	0.0	61.0	64.0	-0.088	0.117	1000.0	-1000.0	-0.091	-1000.0
Atypical NF-kappaB pathway	0.0	20.0	31.0	-0.02	0.035	1000.0	-1000.0	-0.049	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.006	0.026	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	0.0	67.0	71.0	-0.048	0.035	1000.0	-1000.0	-0.06	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.009	0.026	1000.0	-1000.0	-0.04	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.004	0.011	1000.0	-1000.0	-0.055	-1000.0
Total	739	44964	7203	-18.7318982132	-1994.81954016	131000	-131000	-9.01840519805	-131000