Clustering of miRseq mature expression: consensus NMF
Kidney Chromophobe (Primary solid tumor)
17 October 2014
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analyses__2014_10_17
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
Clustering of miRseq mature expression: consensus NMF.
Broad Institute of MIT and Harvard.
doi:10.7908/C1DJ5DJB
Overview
Introduction
Summary
We filtered the data to 647 most variable miRs. Consensus NMF clustering of 48 samples and 647 miRs identified 2 subtypes with the stability of the clustering increasing for k = 2 to k = 8 and the average silhouette width calculation for selecting the robust clusters.
Results
Silhouette width of each sample in robust cluster
miR expression patterns of molecular subtype
Consensus and correlation matrix
Samples assignment with silhouette width
Marker miRs of each subtype
Methods & Data
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Broad Institute TCGA GDAC as part of the TCGA Research Network.
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