rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(7), ATR(6), CHEK1(1), CHEK2(2), TP53(63), YWHAH(1) 4627970 80 72 67 4 22 18 9 6 25 0 4.99e-05 1.55e-15 3.01e-13 2 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(5), AXIN1(10), BTRC(1), CREBBP(6), CSNK2A1(1), CTNNB1(52), DVL1(1), FZD1(1), GSK3B(2), MAP3K7(1), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(1), WNT1(2) 8805327 91 78 64 6 33 8 23 8 18 1 1.04e-05 2.33e-15 3.01e-13 3 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(5), ATM(7), BAX(1), CDKN1A(5), CPB2(2), HIF1A(1), IGFBP3(1), MDM2(1), TP53(63) 6314867 86 76 73 7 26 19 9 7 25 0 0.000244 2.89e-15 3.01e-13 4 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(6), PAX3(3), PML(1), RARA(1), RB1(16), TNF(2), TNFRSF1A(1), TP53(63) 5503411 93 82 80 4 29 17 7 5 34 1 8.92e-07 3.22e-15 3.01e-13 5 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(7), BAX(1), BCL2(1), CCNE1(1), CDKN1A(5), E2F1(1), MDM2(1), RB1(16), TP53(63) 5292075 99 80 86 6 24 19 11 7 37 1 2.79e-05 3.89e-15 3.01e-13 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), NFKB1(2), NFKBIA(2), RELA(1), TP53(63) 3002721 70 68 57 6 24 16 4 3 23 0 0.000609 4.33e-15 3.01e-13 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN1A(5), CDKN2A(1), CFL1(1), E2F1(1), MDM2(1), TP53(63) 2400548 72 68 59 2 20 17 7 5 23 0 1.71e-06 4.33e-15 3.01e-13 8 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(1), SP1(2), SP3(3), TP53(63), WT1(3) 2072209 72 70 59 1 26 15 4 4 23 0 1.12e-07 4.66e-15 3.01e-13 9 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(1), E2F1(1), MDM2(1), MYC(1), PIK3CA(7), PIK3R1(2), POLR1A(1), RB1(16), TBX2(3), TP53(63) 5835542 96 84 82 5 27 18 8 6 36 1 4.81e-06 4.77e-15 3.01e-13 10 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(7), CHEK1(1), MYT1(4), RB1(16), TP53(63), WEE1(2), YWHAH(1) 5188043 94 83 81 6 24 18 9 6 36 1 5.81e-05 4.88e-15 3.01e-13 11 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(4), APC(5), AXIN1(10), BTRC(1), CTNNB1(52), DVL1(1), FZD1(1), GSK3B(2), NOTCH1(1), PSEN1(1), WNT1(2) 6301745 80 72 53 4 28 6 21 9 15 1 7.79e-06 6.33e-15 3.54e-13 12 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(2), IFNGR1(2), IKBKB(3), JAK2(4), NFKB1(2), NFKBIA(2), RB1(16), RELA(1), TNF(2), TNFRSF1A(1), TP53(63), USH1C(2), WT1(3) 5649068 103 84 90 6 31 18 11 5 37 1 2.86e-06 8.44e-15 4.33e-13 13 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(7), ATR(6), CCNA1(1), CCNE1(1), CDKN1A(5), CDKN2A(1), E2F1(1), GSK3B(2), RB1(16), SKP2(1), TFDP1(1), TGFB2(2), TGFB3(2), TP53(63) 8784671 109 86 96 9 27 20 16 7 38 1 0.000109 2.89e-14 1.37e-12 14 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(3), ATM(7), BAX(1), BCL2(1), BID(1), CASP6(1), CASP7(1), PRKCA(1), PTK2(6), PXN(1), STAT1(2), TLN1(3), TP53(63) 7978199 91 78 78 6 33 20 10 4 24 0 8.93e-06 3.11e-14 1.37e-12 15 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 BCL2(1), EGFR(4), IGF1R(6), MYC(1), POLR2A(5), PPP2CA(1), PRKCA(1), RB1(16), TEP1(5), TERF1(4), TNKS(3), TP53(63), XRCC5(1) 8095154 111 90 98 10 32 17 15 5 41 1 4.70e-05 2.80e-12 1.15e-10 16 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(2), BCAR1(2), CTNNA1(1), CTNNA2(3), CTNNB1(52), PECAM1(1), PTK2(6), PXN(1), SRC(1), VCL(3) 5695977 75 63 48 6 29 11 22 7 5 1 0.000152 6.32e-12 2.43e-10 17 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(7), BRCA1(4), CDKN1A(5), CHEK1(1), CHEK2(2), JUN(1), MDM2(1), NFKB1(2), NFKBIA(2), RAD50(1), RAD51(3), RBBP8(2), RELA(1), TP53(63), TP73(1) 8655948 96 83 83 8 31 20 11 7 27 0 0.000163 4.69e-11 1.70e-09 18 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(10), CREBBP(6), CTNNB1(52), DVL1(1), EP300(3), FZD1(1), GSK3B(2), LDB1(1), LEF1(2), TRRAP(4), WNT1(2) 9652790 89 75 62 8 34 6 24 8 16 1 0.000107 6.96e-10 2.38e-08 19 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT2(3), AKT3(1), ANKRD6(1), APC(5), AXIN1(10), AXIN2(3), CER1(2), CTNNB1(52), DACT1(3), DKK1(1), DKK2(2), DKK3(1), DVL1(1), GSK3B(2), LRP1(12), NKD1(1), NKD2(1), PIN1(1), PSEN1(1), PTPRA(2), SENP2(4), WIF1(1) 11904601 110 89 83 10 37 14 28 9 21 1 4.98e-05 3.11e-06 0.000101 20 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(5), AXIN1(10), CTNNB1(52), DVL1(1), FZD1(1), GJA1(2), GNAI1(2), GSK3B(2), IRAK1(2), LBP(2), LEF1(2), LY96(1), MYD88(1), NFKB1(2), PIK3CA(7), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2), WNT1(2) 9140343 100 85 72 11 41 9 22 8 19 1 0.000173 7.56e-05 0.00233 21 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(16), SP1(2), SP3(3) 1965831 22 21 22 3 3 0 3 2 13 1 0.361 0.000123 0.00361 22 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(1), CCND2(1), CCNE1(1), CCNH(1), CDK7(1), CDKN1A(5), CDKN2A(1), E2F1(1), RB1(16), RBL1(3), TFDP1(1) 4638102 33 29 33 3 6 4 6 2 14 1 0.0868 0.000275 0.00770 23 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CKS1B(1), CUL1(1), E2F1(1), RB1(16), SKP2(1), TFDP1(1) 2518903 22 21 22 3 2 0 4 1 14 1 0.427 0.000532 0.0142 24 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(5), AXIN1(10), BMP2(1), BMP5(3), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(1), CTNNB1(52), DVL1(1), FZD1(1), GSK3B(2), MAP3K7(1), MEF2C(1), NOG(1), RFC1(3), TGFB2(2), TGFB3(2), TGFBR1(1), WNT1(2) 10685809 96 79 69 10 37 8 25 8 17 1 0.000155 0.000840 0.0216 25 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(5) 206449 5 5 5 0 3 1 1 0 0 0 0.196 0.000910 0.0224 26 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CUL1(1), E2F1(1), FBXW7(1), RB1(16), TFDP1(1) 2491366 21 20 21 4 1 1 4 1 13 1 0.737 0.00139 0.0330 27 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(1), CUL1(1), E2F1(1), RB1(16), SKP2(1), TFDP1(1) 2555129 22 21 22 3 3 0 4 1 13 1 0.418 0.00179 0.0409 28 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PTEN(7), PTK2(6), SHC1(2), SOS1(4) 5794059 33 28 32 1 17 5 2 2 7 0 0.00126 0.00199 0.0438 29 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(8), MAPK1(1), MAPK14(2), NFE2L2(5), PRKCA(1) 2685919 20 17 20 0 10 3 2 2 3 0 0.00422 0.00245 0.0520 30 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(7), ATR(6), BRCA1(4), CCNB1(1), CDKN1A(5), CHEK1(1), CHEK2(2), EP300(3), MDM2(1), MYT1(4), PRKDC(12), RPS6KA1(1), TP53(63), WEE1(2), YWHAH(1) 12693448 113 97 99 12 37 23 15 9 29 0 0.000191 0.00413 0.0848 31 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(7), CCNA1(1), CCNB1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDK7(1), CDKN1A(5), CDKN2A(1), CREB3(1), CREB3L1(2), CREB3L3(2), E2F1(1), E2F3(2), E2F6(2), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), MYC(1), MYT1(4), NACA(2), POLA2(1), POLE(3), POLE2(2), RB1(16), RBL1(3), TFDP1(1), TFDP2(2), TNXB(8), TP53(63), WEE1(2) 22815110 148 104 135 13 45 30 21 10 41 1 1.02e-06 0.00475 0.0943 32 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(7), JUND(1), PPP1R1B(1) 1097157 9 9 9 1 6 1 2 0 0 0 0.169 0.00505 0.0972 33 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(4), PIK3CA(7), PIK3R1(2), PTK2(6), PTK2B(4), RAPSN(1), SRC(1), YWHAH(1) 4891704 26 24 25 2 12 3 4 1 6 0 0.0214 0.00594 0.111 34 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL16(2), IL18(2), IL4(1), IL6(2), LTA(1), TNF(2) 2913639 19 19 19 2 7 1 7 2 2 0 0.0792 0.00648 0.117 35 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(7), ATR(6), BRCA1(4), BRCA2(6), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(2), FANCE(1), FANCG(1), HUS1(1), RAD1(2), RAD50(1), RAD51(3), RAD9A(1), TP53(63), TREX1(1) 12880397 107 88 94 10 37 21 16 5 28 0 7.87e-05 0.0118 0.208 36 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(2), RXRA(5), TNF(2) 1684442 10 10 10 1 4 1 3 2 0 0 0.249 0.0212 0.362 37 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR0B2(2), NR1H3(2), RXRA(5) 1561481 10 10 10 0 5 3 0 2 0 0 0.0499 0.0256 0.425 38 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), JAK1(2), JAK2(4), STAT1(2) 2415080 12 12 12 0 4 0 4 2 2 0 0.0724 0.0286 0.455 39 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(3), FH(2), IDH1(3), IDH2(4), SDHB(1) 2632793 14 13 12 1 9 0 4 1 0 0 0.0527 0.0288 0.455 40 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(2), IL12A(5), IL12B(1), IL18(2) 906619 10 10 10 2 3 1 4 0 2 0 0.431 0.0342 0.527 41 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(3), MPO(5), PRDX1(1), PRDX2(1), TPO(9), TYR(4) 2869824 25 23 25 4 10 5 5 0 5 0 0.113 0.0530 0.797 42 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(9), SDS(2) 1439908 12 7 12 1 6 2 2 1 1 0 0.119 0.0584 0.857 43 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(3), AKT3(1), MAPK1(1), PIK3CA(7), PIK3CD(4), PTEN(7), PTK2B(4), RBL2(5), SHC1(2), SOS1(4) 5922125 38 31 37 4 21 4 2 2 9 0 0.0113 0.0599 0.858 44 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(1), ACAT2(4), ECHS1(1), EHHADH(9), HADHB(1), SDS(2) 2494031 19 14 19 2 9 3 4 1 2 0 0.0699 0.0618 0.865 45 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), CPS1(6), GLS(1), GLUD1(2) 2268970 11 11 11 0 7 1 1 0 2 0 0.0423 0.0654 0.895 46 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(3), BAX(1), BCL2(1), BID(1), BIRC2(1), BIRC3(1), CASP6(1), CASP7(1), CASP8(1), FADD(2), FASLG(1), GZMB(1), JUN(1), MAP2K4(3), MAP3K1(2), MAPK10(3), MCL1(1), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), PRF1(3), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TP53(63), TRAF1(1) 11108410 104 86 91 13 37 21 12 4 30 0 0.000831 0.0674 0.902 47 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(3), MPO(5), TPO(9) 2477193 19 17 19 3 9 5 1 0 4 0 0.114 0.0691 0.906 48 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACAT2(4), ECHS1(1), EHHADH(9), SDHB(1), SDS(2) 2294765 18 13 18 2 9 2 4 1 2 0 0.0821 0.0725 0.931 49 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(4), SHC1(2), SOS1(4), SRC(1) 2538395 11 11 11 0 7 0 2 1 1 0 0.0298 0.0750 0.943 50 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1) 3170618 17 17 17 2 8 5 2 1 1 0 0.0916 0.0873 1.000 51 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCNE1(1), CDKN1A(5), E2F1(1), MAPK1(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3CA(7), PIK3R1(2), RAF1(1), RB1(16), RELA(1), TFDP1(1) 5965512 41 36 40 6 11 4 7 2 16 1 0.182 0.102 1.000 52 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), CDC42(2), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), WASL(1) 3974373 21 20 20 2 13 3 1 1 3 0 0.0450 0.110 1.000 53 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(1), EIF4G1(4), EIF4G2(5), EIF4G3(4), MKNK1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PPP2CA(1), PTEN(7), RPS6KB1(1), TSC1(7), TSC2(9) 8316609 50 41 49 5 25 3 3 1 18 0 0.00440 0.118 1.000 54 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PDXK(1), PSAT1(2) 1403073 7 7 7 0 5 0 1 1 0 0 0.0980 0.125 1.000 55 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 148121 1 1 1 0 0 0 1 0 0 0 0.861 0.127 1.000 56 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(7), GNB1(1), PRKACB(1), PRKAR2B(1), PRKCA(1) 2881981 12 12 10 1 6 2 1 0 3 0 0.168 0.128 1.000 57 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(10), GLI3(6), GSK3B(2), PRKACB(1), PRKAR2B(1), SUFU(3) 4796862 26 25 26 4 5 8 7 2 4 0 0.185 0.138 1.000 58 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDK7(1), CDKN1A(5), CHEK1(1), WEE1(2) 2241496 9 8 9 0 2 3 1 1 2 0 0.172 0.143 1.000 59 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), ADRB2(3), CFTR(5), GNAS(7), PRKACB(1), PRKAR2B(1) 3841220 20 18 18 2 8 4 5 0 3 0 0.111 0.150 1.000 60 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), EPX(2), LPO(3), MPO(5), MTHFR(1), SHMT1(1), SHMT2(2), TPO(9) 3390207 24 20 24 4 11 6 1 0 6 0 0.106 0.150 1.000 61 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(2), IDH2(4), SDHA(3) 2790714 12 11 12 1 6 1 4 1 0 0 0.113 0.168 1.000 62 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(7), ATR(6), BAI1(4), BAX(1), BID(1), CASP8(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CDKN1A(5), CDKN2A(1), CHEK1(1), CHEK2(2), DDB2(1), EI24(2), GTSE1(1), IGFBP3(1), MDM2(1), PTEN(7), RFWD2(2), RPRM(1), SERPINE1(1), SESN1(1), SESN2(4), SESN3(2), SIAH1(4), STEAP3(2), THBS1(3), TP53(63), TP73(1), TSC2(9) 19321964 146 103 133 16 43 30 20 10 43 0 0.000123 0.186 1.000 63 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(3), PRKCA(1), PTK2B(4) 1952851 8 8 8 1 5 0 1 0 2 0 0.281 0.190 1.000 64 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(4), GREB1(4), HSPB2(3), MTA1(1), PDZK1(1), TUBA8(2) 3337310 16 16 16 2 11 0 3 0 2 0 0.0553 0.191 1.000 65 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(1), ACO2(3), FH(2), IDH1(3), IDH2(4) 3908854 15 14 13 1 10 0 4 1 0 0 0.0387 0.200 1.000 66 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB1A(1), RAB4A(2), RAB6A(1), RAB9A(1) 1265047 5 5 5 1 2 2 0 0 1 0 0.608 0.204 1.000 67 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(2), JAK1(2), JAK2(4), STAT1(2) 3370251 14 14 14 2 4 1 4 2 3 0 0.400 0.206 1.000 68 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP8(1), CFL1(1), CFLAR(1) 1118316 4 4 4 1 1 0 1 0 2 0 0.690 0.214 1.000 69 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3), GPX1(1) 1927366 17 16 17 4 6 5 2 1 3 0 0.502 0.214 1.000 70 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA4(2), PSMA7(3), PSMB10(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMB9(1) 2573799 12 10 12 1 5 2 5 0 0 0 0.133 0.220 1.000 71 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD1(2), GLUD2(3) 1294013 6 6 6 1 5 0 1 0 0 0 0.313 0.226 1.000 72 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP6(1), CASP7(1), CASP8(1), CFLAR(1), DFFB(1), FADD(2), FAF1(2), JUN(1), LMNA(2), LMNB1(1), LMNB2(2), MAP2K4(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(12), PTPN13(11), RB1(16), RIPK2(1), SPTAN1(4) 12690303 67 57 66 8 23 10 9 3 21 1 0.0125 0.240 1.000 73 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(2), GLS(1), GLUD1(2), OAT(2) 1712301 7 7 7 0 6 0 1 0 0 0 0.0734 0.254 1.000 74 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), HMBS(2) 2296292 8 8 8 0 3 1 2 0 2 0 0.109 0.255 1.000 75 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), CAMK2A(3), CAMK2B(1), GNAS(7), MAPK1(1), MAPK14(2), PIK3CA(7), PIK3R1(2), PRKACB(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(4) 8666303 35 32 32 3 20 6 4 0 5 0 0.00603 0.275 1.000 76 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(1), MAP2K2(2), MAP3K1(2), MAPK1(1), MAPK14(2), NFKB1(2), PIK3CA(7), PIK3R1(2), RB1(16), RELA(1), SP1(2) 5810046 38 32 37 8 16 2 4 1 14 1 0.285 0.297 1.000 77 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(4), JAK3(3), MAPK1(1), STAT3(3), TYK2(2) 3547214 15 15 15 2 9 0 3 2 1 0 0.139 0.321 1.000 78 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2), SNAP25(1) 914461 3 3 3 1 1 0 1 1 0 0 0.780 0.330 1.000 79 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 NTRK1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), SHC1(2), SOS1(4) 4606812 21 21 20 3 15 2 0 1 3 0 0.0739 0.334 1.000 80 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MYC(1), PIK3CA(7), PIK3R1(2), RAF1(1), SOS1(4), STAT1(2), STAT5A(2), STAT5B(1) 8152897 35 33 34 4 18 3 5 1 8 0 0.0328 0.342 1.000 81 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(1), EIF4G1(4), EIF4G2(5), EIF4G3(4), GHR(1), MAPK1(1), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PRKCA(1), PTEN(7), RPS6KB1(1) 8387003 39 32 38 4 25 2 3 0 9 0 0.00510 0.348 1.000 82 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(2), BIRC3(1), CASP8(1), FADD(2), RIPK1(2), TNF(2), TNFRSF1A(1) 2418304 11 11 11 2 5 3 1 1 1 0 0.337 0.364 1.000 83 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(1), F3(1), F5(4), FGA(6), PROC(1), PROS1(2), SERPINC1(2) 4889018 20 20 19 2 9 4 4 0 3 0 0.0543 0.365 1.000 84 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), IL6(2), LDLR(1), LPL(1) 1548631 5 5 5 1 2 1 2 0 0 0 0.533 0.373 1.000 85 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(2), CTH(1), MUT(1) 1444692 5 5 5 1 2 0 1 0 2 0 0.596 0.375 1.000 86 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(3), HDC(2), TH(2), TPH1(2) 1743742 9 9 9 2 5 1 0 1 2 0 0.429 0.386 1.000 87 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(1), HGD(1) 647836 2 2 2 1 0 1 1 0 0 0 0.881 0.391 1.000 88 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), GATM(1), GLUD1(2), NAGS(1), OAT(2), ODC1(1) 5495739 19 19 19 2 12 2 2 1 2 0 0.0589 0.412 1.000 89 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(3), IL6(2), JAK1(2), STAT1(2), STAT3(3), STAT5A(2), TNF(2) 3627792 18 16 18 3 5 2 10 1 0 0 0.337 0.417 1.000 90 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD80(1), CD86(1), CTLA4(1), LCK(3), PIK3CA(7), PIK3R1(2), PTPN11(1) 3762261 16 14 15 2 7 4 3 0 2 0 0.182 0.437 1.000 91 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1), SQLE(1) 980074 3 3 3 1 1 0 0 1 1 0 0.671 0.455 1.000 92 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), ALAS2(1), FECH(1), HMBS(2) 2507639 7 7 7 0 3 0 2 0 2 0 0.133 0.473 1.000 93 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 442329 1 1 1 0 0 1 0 0 0 0 0.880 0.483 1.000 94 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(4), FURIN(3), NOTCH1(1), PSEN1(1) 2773353 9 9 9 1 6 1 0 1 1 0 0.145 0.484 1.000 95 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(2), CYP11A1(1), CYP11B1(1), CYP11B2(6), CYP17A1(1), CYP21A2(1) 2678385 12 11 12 2 7 4 1 0 0 0 0.174 0.484 1.000 96 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(2), CYP11A1(1), CYP11B1(1), CYP11B2(6), CYP17A1(1), CYP21A2(1) 2678385 12 11 12 2 7 4 1 0 0 0 0.174 0.484 1.000 97 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(1), ACAT1(1), ECHS1(1) 1600071 4 4 4 1 1 1 1 0 1 0 0.747 0.489 1.000 98 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(4), ERBB3(6), NRG1(2) 2976010 16 15 16 3 5 3 4 0 4 0 0.349 0.491 1.000 99 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2D3(2), UBE2J1(3), UBE2J2(1), UBE2L3(1), UBE2N(4), UBE2S(1), UBE3A(1) 3065851 13 12 13 2 6 4 2 0 1 0 0.228 0.501 1.000 100 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), OPRK1(1), POLR2A(5), PRKACB(1), PRKAR2B(1) 3714962 11 11 11 0 4 0 5 0 2 0 0.0807 0.529 1.000 101 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), GGPS1(1), IDI1(1), SQLE(1) 1293264 4 4 4 1 2 0 0 1 1 0 0.528 0.544 1.000 102 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(2), FUT9(2), GCNT2(1), ST8SIA1(1) 1800286 6 5 6 1 0 2 3 0 1 0 0.551 0.552 1.000 103 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ6(2) 1256106 3 3 3 1 1 0 0 1 1 0 0.809 0.565 1.000 104 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(1), SPCS3(1) 910568 2 2 2 1 2 0 0 0 0 0 0.802 0.585 1.000 105 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(4), EGFR(4), PDGFRA(4), PRKCA(1), SH3GLB1(1), SH3KBP1(1), SRC(1) 5682635 17 16 17 2 7 0 5 1 4 0 0.119 0.586 1.000 106 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGB(1), PIGC(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(4), PIGS(2), PIGV(1), PIGW(1), PIGZ(2) 7309488 19 18 19 1 6 4 3 1 5 0 0.0482 0.594 1.000 107 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), EPX(2), LPO(3), MPO(5), PRDX1(1), PRDX2(1), SHMT1(1), SHMT2(2), TPO(9) 3479243 25 21 25 5 10 6 2 0 7 0 0.199 0.611 1.000 108 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), AOC2(2), AOC3(1), CES1(1) 1778939 6 6 6 0 4 0 2 0 0 0 0.130 0.613 1.000 109 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(2), JAK2(4), MAP2K1(1), PTPN6(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1) 5300798 19 18 19 2 11 2 2 2 2 0 0.0762 0.619 1.000 110 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(4), ACPT(1), ENPP3(1), FLAD1(3), TYR(4) 2875643 14 12 14 3 6 1 5 1 1 0 0.384 0.622 1.000 111 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(3), SDHB(1) 1917179 5 5 5 0 2 1 2 0 0 0 0.260 0.622 1.000 112 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(4), NRG2(2), NRG3(2), PRKCA(1), PSEN1(1) 2651073 14 14 14 3 7 4 2 1 0 0 0.341 0.638 1.000 113 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1) 507526 1 1 1 1 1 0 0 0 0 0 0.886 0.643 1.000 114 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), CD4(1), IL1B(1), IL4(1), IL5RA(1), IL6(2) 1555243 8 7 8 2 1 4 2 0 1 0 0.593 0.643 1.000 115 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(2), IL6R(1), JAK1(2), JAK2(4), JAK3(3), SRC(1), STAT3(3) 4542489 18 17 18 3 7 1 5 2 3 0 0.321 0.650 1.000 116 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2) 1646154 4 4 4 1 1 1 0 0 2 0 0.735 0.655 1.000 117 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), ADRB2(3), GNAS(7), PLCE1(4), PRKACB(1), PRKAR2B(1) 4358835 19 15 17 2 10 4 4 0 1 0 0.0810 0.658 1.000 118 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(1), CAPNS1(1), GSK3B(2), MAPT(3), PPP2CA(1) 2880122 10 10 10 2 5 0 1 1 3 0 0.280 0.659 1.000 119 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), JUNB(1), MAPK14(2), NFATC2(3), PRKACB(1), PRKAR2B(1) 3491444 9 9 9 0 4 1 2 1 1 0 0.0961 0.663 1.000 120 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), CRY1(3), CSNK1E(2), PER1(2) 2474644 9 9 9 2 5 0 3 1 0 0 0.385 0.682 1.000 121 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 CHST11(1), CHST12(1), CHST13(1), SULT1A2(1), SULT2B1(2), SUOX(2) 3379204 8 8 8 1 4 2 0 0 2 0 0.289 0.687 1.000 122 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(2), NFKB1(2), NOX1(3), RELA(1), TNF(2), XDH(4) 2982163 15 14 15 3 9 2 4 0 0 0 0.224 0.687 1.000 123 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), FOS(2), IL6(2), IL6R(1), IL6ST(7), JAK1(2), JAK2(4), JAK3(3), JUN(1), MAP2K1(1), PTPN11(1), RAF1(1), SHC1(2), SOS1(4), STAT3(3) 7049578 35 32 35 5 16 1 6 3 9 0 0.0951 0.688 1.000 124 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1) 1506101 4 4 4 1 3 0 1 0 0 0 0.528 0.691 1.000 125 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(6), CYP17A1(1) 2037209 8 7 8 2 3 4 1 0 0 0 0.436 0.693 1.000 126 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 593087 1 1 1 0 1 0 0 0 0 0 0.664 0.702 1.000 127 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2) 3923945 12 12 12 2 5 2 2 0 3 0 0.319 0.716 1.000 128 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(3), AKT3(1), CDKN1A(5), MAP2K1(1), MAP2K2(2), NGFR(1), NTRK1(2), PIK3CA(7), PIK3CD(4), SHC1(2), SOS1(4) 4894195 32 26 31 5 19 6 3 2 2 0 0.0508 0.716 1.000 129 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3) 1972710 11 10 11 3 7 3 1 0 0 0 0.361 0.721 1.000 130 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(8), RANGAP1(2) 2364374 10 8 10 2 4 3 1 0 2 0 0.479 0.725 1.000 131 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(2), CTH(1), DNMT1(3), DNMT3A(2), MARS(3), MARS2(1), MAT1A(3), MTR(1) 5155431 16 13 16 2 3 4 2 4 3 0 0.193 0.731 1.000 132 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(2) 1150945 2 2 2 1 0 1 0 0 1 0 0.932 0.739 1.000 133 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1) 860076 2 2 2 0 0 2 0 0 0 0 0.610 0.742 1.000 134 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(2), CASP8(1), CRADD(1), DFFB(1), FADD(2), JUN(1), LMNA(2), LMNB1(1), LMNB2(2), MADD(1), MAP2K4(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(12), RB1(16), RIPK1(2), SPTAN1(4), TNF(2), TNFRSF1A(1) 11754126 58 54 57 9 17 8 7 4 21 1 0.0863 0.758 1.000 135 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(1), MBTPS1(2), MBTPS2(1), SCAP(2), SREBF1(4), SREBF2(2) 3628786 14 14 14 3 6 4 1 0 3 0 0.338 0.770 1.000 136 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(7), PIK3R1(2), PLCB1(5), PLCG1(3), PRKCA(1), VAV1(3) 3804343 21 20 20 4 11 5 2 0 3 0 0.249 0.775 1.000 137 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAPK1(1), MAPK14(2), PAK1(1), PLCG1(3), PRKCA(1), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), SRC(1) 8351072 31 30 31 4 18 2 5 1 5 0 0.0441 0.787 1.000 138 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(5), AKT2(3), AKT3(1), BTK(1), CDKN2A(1), DAPP1(1), GSK3B(2), IARS(1), INPP5D(1), PIK3CA(7), PPP1R13B(5), PTEN(7), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SHC1(2), SOS1(4), SOS2(2), YWHAE(2), YWHAH(1), YWHAZ(1) 10485159 58 47 57 8 28 6 9 4 11 0 0.0118 0.797 1.000 139 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(6), FOS(2), GAB1(4), HGF(5), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(1), MAP2K2(2), MAP4K1(1), MAPK1(1), PAK1(1), PIK3CA(7), PIK3R1(2), PTEN(7), PTK2(6), PTK2B(4), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(4), SOS1(4), SRC(1), STAT3(3) 13403724 70 50 69 8 37 9 11 2 11 0 0.00111 0.798 1.000 140 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 2152263 4 4 4 1 0 1 1 0 2 0 0.750 0.801 1.000 141 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), TYR(4) 1371416 5 5 5 2 1 0 4 0 0 0 0.834 0.818 1.000 142 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(7), GNB1(1), PRKACA(1) 1934829 12 11 10 3 6 3 2 0 1 0 0.530 0.824 1.000 143 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), UGDH(1) 1187791 2 2 2 0 1 0 0 0 1 0 0.556 0.825 1.000 144 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(4), MPI(1), PYGL(1), PYGM(5) 4080705 12 12 12 2 8 2 0 0 2 0 0.198 0.826 1.000 145 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), HTR2C(4), PLCB1(5), TUB(1) 2093699 11 11 11 3 3 2 3 0 3 0 0.637 0.836 1.000 146 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 GH1(1), GHR(1), IGF1R(6), PIK3CA(7), PIK3R1(2), SHC1(2) 3838313 19 18 18 4 11 2 2 1 3 0 0.227 0.848 1.000 147 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(1), LUM(1) 1052911 4 4 4 2 2 0 1 0 1 0 0.926 0.851 1.000 148 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(4), EGFR(4), HGS(4), TF(1), TFRC(1) 3742601 16 15 16 4 3 2 5 0 6 0 0.672 0.863 1.000 149 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA4(2), PSMA7(3), PSMB5(2), PSMB6(1), PSMB7(1), PSMD14(1), UBE3A(1) 3907545 12 9 12 2 5 2 5 0 0 0 0.286 0.869 1.000 150 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1) 6830089 15 15 15 1 7 2 2 1 3 0 0.0701 0.873 1.000 151 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), ACAT2(4) 1001643 5 5 5 3 2 0 2 0 1 0 0.892 0.874 1.000 152 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAX(1), BCL2(1), BID(1), BIK(1), BIRC2(1), BIRC3(1), CASP6(1), CASP7(1), CASP8(1), DFFB(1), ENDOG(1) 3956668 14 13 14 3 6 2 1 2 3 0 0.429 0.875 1.000 153 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), CHST1(1), CHST2(3), FUT8(1), ST3GAL1(1), ST3GAL3(1) 3444297 12 12 12 3 5 1 3 0 3 0 0.477 0.889 1.000 154 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(3), BCL2(1), FASLG(1), HSPB2(3), MAPKAPK2(1), MAPKAPK3(1), TNF(2) 3250488 12 12 12 3 5 2 2 0 3 0 0.395 0.892 1.000 155 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(9), HADH(1), SIRT2(2), VNN2(2) 3502517 15 10 15 2 10 2 2 1 0 0 0.0951 0.894 1.000 156 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), HEMK1(2), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT6(2), PRMT7(1), PRMT8(1) 4082724 17 16 17 3 9 4 2 1 1 0 0.270 0.894 1.000 157 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFA5(1), NDUFV2(1) 2079183 3 3 3 1 1 2 0 0 0 0 0.737 0.898 1.000 158 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), CNR2(1), DNMT1(3), MTNR1A(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2) 3229046 12 11 12 3 7 2 1 1 1 0 0.292 0.898 1.000 159 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(3), POLG(4), POLQ(7) 4895348 16 16 16 3 8 5 1 1 1 0 0.250 0.901 1.000 160 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), UGDH(1) 1491522 2 2 2 0 1 0 0 0 1 0 0.556 0.908 1.000 161 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(3), BAX(1), BCL2(1), BID(1), BIRC2(1), BIRC3(1), CASP10(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CHUK(2), DFFB(1), FADD(2), FASLG(1), GZMB(1), IKBKB(3), IRF1(1), IRF2(3), IRF3(1), IRF4(1), JUN(1), LTA(1), MAP2K4(3), MAP3K1(2), MAPK10(3), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), PLEKHG5(1), PRF1(3), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TP53(63), TP73(1), TRAF1(1) 17125234 125 94 112 18 46 24 15 6 34 0 0.000941 0.919 1.000 162 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(7), CHEK1(1), MYT1(4), WEE1(2), YWHAH(1) 4056924 15 14 15 3 4 3 4 2 2 0 0.417 0.920 1.000 163 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), CFL1(1), GNAS(7), GNB1(1), MAP2K1(1), MAPK1(1), NOX1(3), PIK3C2G(5), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2(6), RAF1(1), ROCK2(3) 7554889 38 34 36 5 20 8 7 1 2 0 0.0341 0.922 1.000 164 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(2), IL6(2), KITLG(2), TGFB2(2), TGFB3(2) 2539008 11 11 11 3 6 0 3 0 2 0 0.437 0.929 1.000 165 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(1), RDH12(1), RDH13(1) 1351019 4 4 4 2 2 0 1 0 1 0 0.870 0.931 1.000 166 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(1), EIF2B5(1), EIF2S3(1), GSK3B(2), PPP1CA(2) 3375726 9 9 9 2 6 0 0 1 2 0 0.307 0.933 1.000 167 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(2), IMPDH1(2), POLD1(2), POLG(4), PRPS2(1), RRM1(1), SRM(2) 3783007 15 12 15 3 8 3 3 0 1 0 0.227 0.933 1.000 168 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT3(1), GALNT4(2), GALNT6(3), GALNT8(2), ST3GAL1(1), WBSCR17(5) 4298000 16 15 16 3 6 4 3 2 1 0 0.271 0.936 1.000 169 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), CDC42(2), WASL(1) 2421908 7 7 7 2 5 1 0 0 1 0 0.528 0.937 1.000 170 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1), SHMT2(2) 1275936 3 3 3 2 1 1 0 0 1 0 0.901 0.939 1.000 171 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(1), FPGS(2) 2020809 6 6 6 2 3 2 0 0 1 0 0.712 0.940 1.000 172 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(1), GALNT1(2), GALNT11(1), GALNT12(2), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(3), GALNT8(2), GALNTL5(2), GCNT3(1), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(5) 9431722 30 29 29 4 14 8 5 2 1 0 0.0462 0.942 1.000 173 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), DUSP14(1), IFNG(2), IFRD1(1), IL18(2), IL1R1(3), JUND(1), NR4A3(2) 3243137 13 12 13 3 5 1 5 0 2 0 0.388 0.944 1.000 174 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(1), CFLAR(1), E2F1(1), FOS(2), IL2RB(3), JAK1(2), JAK3(3), MAPK1(1), MYC(1), NMI(2), PIK3CA(7), PIK3R1(2), PTPN6(1), RAF1(1), RPS6KB1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1), SYK(1) 10643774 40 38 39 5 24 5 5 2 4 0 0.00940 0.944 1.000 175 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(1), BMPR2(3) 1813138 5 4 5 2 3 0 0 0 2 0 0.636 0.945 1.000 176 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(2), CTH(1), DNMT1(3), DNMT3A(2), MARS(3), MARS2(1), MAT1A(3), MTAP(1), MTR(1), SRM(2) 6152937 19 16 19 3 5 4 2 4 4 0 0.178 0.946 1.000 177 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(3), C6(1), C7(1), C9(2) 3762282 15 14 15 5 6 1 2 1 5 0 0.710 0.949 1.000 178 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(3), ESR1(4), MAPK1(1), PELP1(4), SRC(1) 4411433 19 16 19 4 12 1 4 0 2 0 0.172 0.951 1.000 179 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), JAK1(2), JAK2(4), JAK3(3), STAT1(2), STAT3(3), STAT5A(2), STAT5B(1), TYK2(2) 5610370 22 20 22 4 10 2 6 2 2 0 0.224 0.951 1.000 180 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), EIF2S3(1), GSK3B(2), IGF1R(6), INPPL1(2), PDK2(1), PIK3CA(7), PIK3R1(2), PPP2CA(1), PTEN(7), RPS6KB1(1) 6001708 31 26 30 6 13 3 4 1 10 0 0.186 0.955 1.000 181 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS3(1), DHRS7(1), HEMK1(2), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1) 4348313 16 15 16 3 9 4 2 0 1 0 0.280 0.956 1.000 182 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(2), FYN(1), JUN(1), MAPK14(2), THBS1(3) 2078065 10 10 10 3 5 1 3 1 0 0 0.551 0.958 1.000 183 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP2E1(1), PTGS1(1), PTGS2(1) 1543342 3 3 3 2 1 0 0 1 1 0 0.932 0.959 1.000 184 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AKT2(3), AKT3(1), APAF1(3), ATM(7), BAX(1), BCL2(1), BID(1), BIRC2(1), BIRC3(1), CAPN1(1), CASP10(1), CASP6(1), CASP7(1), CASP8(1), CFLAR(1), CHUK(2), CSF2RB(1), DFFB(1), ENDOG(1), FADD(2), FASLG(1), IKBKB(3), IL1B(1), IL1R1(3), IRAK1(2), IRAK3(3), IRAK4(2), MYD88(1), NFKB1(2), NFKBIA(2), NTRK1(2), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PPP3CA(4), PRKACA(1), PRKACB(1), PRKAR2B(1), RELA(1), RIPK1(2), TNF(2), TNFRSF10D(1), TNFRSF1A(1), TP53(63) 24911369 152 111 138 18 66 29 16 6 35 0 5.38e-06 0.960 1.000 185 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA2B(2), ADORA3(2), LTB4R(1), P2RY1(4), P2RY6(1) 1643211 11 11 11 4 2 3 5 1 0 0 0.697 0.961 1.000 186 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), EPX(2), HPD(2), LPO(3), MAOA(2), MAOB(2), MPO(5), PRDX1(1), PRDX2(1), TPO(9) 6479720 35 30 35 7 16 6 7 0 6 0 0.107 0.966 1.000 187 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCA(1), SNCAIP(1), UBE2L3(1) 1815180 5 5 5 2 3 1 1 0 0 0 0.680 0.968 1.000 188 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(2), CTH(1), MARS(3), MARS2(1), MAT1A(3), SCLY(2), SEPHS1(1) 3680358 13 10 13 3 4 4 1 3 1 0 0.486 0.969 1.000 189 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), GPI(2), HK1(1), PFKL(1), PGAM1(1) 2697414 7 7 7 3 3 1 0 0 3 0 0.823 0.969 1.000 190 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP72(2) 2205265 4 3 4 2 1 1 0 0 2 0 0.925 0.970 1.000 191 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 CDC42(2), DLD(1), DUSP8(1), GAB1(4), IL1R1(3), JUN(1), MAP2K4(3), MAP3K1(2), MAP3K11(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAPK10(3), MAPK7(4), MAPK9(1), MYEF2(1), NFATC3(1), NR2C2(1), PAPPA(3), SHC1(2), TP53(63), TRAF6(1), ZAK(1) 14719900 111 88 98 17 41 19 13 6 32 0 0.00324 0.972 1.000 192 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(2), FUT3(1), ST3GAL3(1) 1483211 4 3 4 3 1 0 2 0 1 0 0.944 0.972 1.000 193 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 SULT1A2(1), SUOX(2) 2497699 3 3 3 0 3 0 0 0 0 0 0.304 0.972 1.000 194 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), NCKAP1(2), NTRK1(2), PSMA7(3), WASF2(2), WASF3(2), WASL(1) 4513810 16 14 16 3 13 2 1 0 0 0 0.124 0.972 1.000 195 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), IFNG(2), IFNGR1(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18(2), IL18R1(1), IL4(1), IL4R(1) 3720452 23 21 23 5 9 2 6 1 5 0 0.276 0.973 1.000 196 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT9(2), GBGT1(1), GLA(1), HEXA(1), NAGA(2), ST3GAL1(1), ST8SIA1(1) 2904994 11 10 11 3 1 1 7 0 2 0 0.711 0.973 1.000 197 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(2), JAK2(4), TYK2(2) 3062068 12 11 12 3 5 0 3 2 2 0 0.553 0.974 1.000 198 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(2), JAK2(4), TYK2(2) 3062068 12 11 12 3 5 0 3 2 2 0 0.553 0.974 1.000 199 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), ACAT2(4), BDH1(1), BDH2(1), HMGCS1(2) 2237166 9 9 9 3 4 1 2 1 1 0 0.639 0.975 1.000 200 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(1), ST3GAL1(1), ST3GAL3(1) 2243377 7 7 7 3 3 1 1 0 2 0 0.839 0.978 1.000 201 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(1), ITPKB(1) 1737280 3 3 3 5 2 0 0 0 1 0 0.999 0.979 1.000 202 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(1), PDHA1(1), PDHA2(3), PDHB(1) 2944139 8 8 8 2 6 2 0 0 0 0 0.402 0.980 1.000 203 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), LDHA(1) 1955458 2 2 2 1 2 0 0 0 0 0 0.750 0.980 1.000 204 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), SHMT1(1), SHMT2(2) 1705440 4 4 4 2 2 1 0 0 1 0 0.816 0.981 1.000 205 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR6(2), NFS1(1), PHPT1(1), TPK1(1) 1869867 7 7 7 5 3 2 0 1 1 0 0.967 0.982 1.000 206 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), FUT1(2), FUT3(1), ST3GAL3(1) 2100062 5 4 5 2 1 0 3 0 1 0 0.812 0.982 1.000 207 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(1), CYP2A7(3), XDH(4) 2366780 10 9 10 3 4 3 3 0 0 0 0.568 0.982 1.000 208 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(1), IL1B(1), IL6R(1), SELL(1), SPN(1), TGFB2(2), TNF(2), TNFRSF1A(1), TNFRSF8(1) 4094494 13 12 13 3 4 2 2 2 3 0 0.476 0.982 1.000 209 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHPT1(1), ENPP2(1), ENPP6(2), PAFAH2(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(3), PPAP2C(3) 6951113 36 31 36 6 21 6 4 1 4 0 0.0261 0.982 1.000 210 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3), GPHN(5), SRC(1), UBQLN1(1) 3754073 23 22 23 6 6 6 6 1 4 0 0.601 0.983 1.000 211 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 CLTB(1), COPA(4), GBF1(2) 4752734 7 7 7 1 5 1 1 0 0 0 0.269 0.984 1.000 212 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), BAX(1), BCL2(1), CSF2RB(1), IGF1R(6), KIT(5), KITLG(2), PIK3CA(7), PIK3R1(2), PRKACB(1), PRKAR2B(1), YWHAH(1) 6426341 31 25 30 6 12 5 5 1 8 0 0.191 0.985 1.000 213 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), PRKCA(1), PTPRA(2), SRC(1) 2716276 5 5 5 2 2 0 2 0 1 0 0.757 0.985 1.000 214 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), FOS(2), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), PDGFA(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2) 10354864 48 45 47 8 24 3 8 4 9 0 0.0674 0.985 1.000 215 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), LCT(4), MAN2C1(2), NEU1(3), NEU2(3), NEU3(2) 4977294 19 17 19 4 12 2 5 0 0 0 0.175 0.985 1.000 216 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), GZMB(1), ICAM1(1), ITGAL(3), ITGB2(2), PRF1(3) 2505960 11 11 11 4 5 2 2 0 2 0 0.569 0.986 1.000 217 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD4(1), IL6(2), KITLG(2) 1840363 5 5 5 3 2 1 1 0 1 0 0.914 0.987 1.000 218 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(4), AASS(2) 2030586 7 7 7 4 4 0 1 1 1 0 0.890 0.988 1.000 219 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2), STAT5B(1) 8865450 41 37 40 7 22 3 5 3 8 0 0.0922 0.989 1.000 220 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(4), EGFR(4), FOS(2), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2) 11089109 51 49 50 9 23 3 10 3 12 0 0.101 0.990 1.000 221 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CXCR3(1), IFNG(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18(2), IL18R1(1), JAK2(4), JUN(1), MAPK14(2), STAT4(3), TYK2(2) 5547864 31 29 31 6 16 3 6 2 4 0 0.111 0.990 1.000 222 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CHUK(2), GH1(1), GHR(1), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3R1(2), PPP2CA(1), RELA(1), YWHAH(1) 4323935 20 19 19 7 11 3 1 1 4 0 0.639 0.992 1.000 223 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2B15(1), UGT2B4(4) 5102912 17 14 17 7 7 1 3 1 5 0 0.883 0.992 1.000 224 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), PRKACB(1), PRKAR2B(1) 2967227 9 9 9 4 4 1 1 1 2 0 0.821 0.992 1.000 225 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(4), MAP2K1(1), MAP3K1(2), MAPK14(2), NCOR2(6), RARA(1), RXRA(5) 5137363 25 23 25 5 13 2 5 1 4 0 0.202 0.993 1.000 226 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), RPL10A(1), RPL10L(1), RPL11(1), RPL13(1), RPL18(1), RPL23A(1), RPL27(1), RPL3(1), RPS10(1), RPS23(1), RPS3(1), RPS4Y1(2), RPS9(1) 6305597 16 15 16 3 9 2 1 1 3 0 0.267 0.993 1.000 227 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4) 3080098 10 10 10 3 8 0 2 0 0 0 0.460 0.994 1.000 228 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(1), BIRC3(1), CASP10(1), CASP7(1), CASP8(1), DFFB(1), GZMB(1), PRF1(3), SCAP(2), SREBF1(4), SREBF2(2) 5481130 21 18 21 5 6 6 2 1 6 0 0.479 0.994 1.000 229 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(1), MMP2(1), MMP9(1), RECK(2), TIMP4(3) 2206197 8 7 8 3 3 2 2 0 1 0 0.776 0.994 1.000 230 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(2), CASP10(1), CASP8(1), GZMB(1), JUN(1), PRF1(3) 3717936 12 12 12 4 3 4 2 0 3 0 0.732 0.994 1.000 231 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS3(1), DHRS7(1), HSD3B7(1), PON3(1), RDH12(1), RDH13(1) 2593667 6 5 6 2 2 1 2 0 1 0 0.777 0.994 1.000 232 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADH(1), HADHB(1), PPT2(2) 2535795 5 5 5 2 3 1 1 0 0 0 0.682 0.994 1.000 233 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), BIRC3(1), CASP10(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), DFFB(1), GZMB(1), LMNA(2), LMNB1(1), LMNB2(2), PRF1(3) 5690472 22 21 22 5 6 5 4 1 6 0 0.405 0.995 1.000 234 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE1(1), CCNE2(1), CDKN2A(1), E2F1(1) 2605762 5 5 5 2 1 0 4 0 0 0 0.828 0.995 1.000 235 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(2), JAK2(4), JAK3(3) 4151864 11 11 11 3 5 1 1 2 2 0 0.616 0.995 1.000 236 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(6), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), RAF1(1), SHC1(2), SOS1(4), YWHAH(1) 5502682 25 22 24 5 16 2 3 2 2 0 0.150 0.996 1.000 237 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 DDX20(1), E2F1(1), ETS1(1), ETS2(1), ETV3(1), FOS(2), HDAC2(1), JUN(1), NCOR2(6), RBL1(3), RBL2(5), SIN3A(2), SIN3B(1) 7915380 26 21 26 4 14 1 5 1 5 0 0.0913 0.996 1.000 238 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), ARHGEF1(1), F2(1), F2RL3(1), GNA13(2), GNAI1(2), GNB1(1), MAP3K7(1), PIK3CA(7), PIK3R1(2), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2B(4), ROCK1(3) 7570219 35 29 34 6 15 8 5 2 5 0 0.136 0.996 1.000 239 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(2), ABCB4(2), ABCC3(5), GSTP1(2) 4276100 16 13 16 4 7 5 2 1 1 0 0.391 0.996 1.000 240 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(3), DLD(1), DLST(2), FH(2), IDH1(3), IDH2(4), IDH3G(1), PC(4), PCK1(5), SDHA(3), SDHB(1), SUCLG1(2) 6065298 32 29 30 7 20 4 5 1 2 0 0.130 0.996 1.000 241 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2B(1), GTF2E1(1), HDAC3(1), NCOA1(2), NCOA2(4), NCOA3(6), NCOR2(6), POLR2A(5), RARA(1), RXRA(5) 7390105 35 30 35 7 16 6 5 2 6 0 0.172 0.996 1.000 242 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(1), MST1(3), MST1R(2), TNF(2) 1877861 8 7 8 4 5 0 2 0 1 0 0.732 0.996 1.000 243 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(4), ESR2(1), PDE1A(1), PDE1B(1), PLCB1(5), PLCB2(2), PRL(2) 3252940 16 15 16 7 7 4 3 0 2 0 0.778 0.997 1.000 244 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), NFKBIA(2), PLCB1(5), PRKCA(1), RELA(1) 2456755 11 11 11 5 6 2 2 0 1 0 0.815 0.997 1.000 245 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), IL18(2), ITGB1(1), MAP2K1(1), PAK1(1), PIK3CA(7), PIK3R1(2), PTK2B(4), PTPN6(1), SYK(1), VAV1(3) 5587751 24 21 23 8 12 4 2 1 5 0 0.624 0.997 1.000 246 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 4760344 8 8 8 2 3 2 2 0 1 0 0.486 0.997 1.000 247 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CDKN1A(5), NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKCA(1), SP1(2), SP3(3) 5899245 26 21 26 5 14 3 3 3 3 0 0.185 0.997 1.000 248 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(5), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(2), NFKBIA(2), RELA(1) 3830633 18 16 18 5 8 2 3 2 3 0 0.609 0.997 1.000 249 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(2), EPHB2(4), F2(1), F2RL3(1), JUN(1), MAPK1(1), MAPK7(4), MYEF2(1), PLD1(2), PLD2(2), PLD3(3), PTK2(6), RAF1(1), RASAL1(3), SRC(1), VAV1(3) 8095072 37 31 37 6 19 6 10 1 1 0 0.0532 0.997 1.000 250 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDPS(1), HMGCR(4), IDI1(1), LSS(1), MVK(1), PMVK(2), SQLE(1) 3266679 11 9 11 4 2 3 1 2 3 0 0.801 0.998 1.000 251 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(2), JUN(1), MAPK14(2), PLCG1(3), PRKCA(1), PTK2B(4) 3962562 14 14 14 4 9 0 3 0 2 0 0.443 0.998 1.000 252 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(2) 3199729 9 9 9 3 3 0 3 2 1 0 0.727 0.998 1.000 253 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), FDXR(1), SHMT1(1) 4722513 12 12 12 3 2 1 4 1 4 0 0.765 0.998 1.000 254 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(7), BUB1(1), BUB1B(1), CCNA1(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDAN1(2), CDC14B(2), CDC7(3), CDH1(2), CDKN1A(5), CDKN2A(1), CHEK1(1), CHEK2(2), E2F1(1), E2F3(2), E2F6(2), EP300(3), ESPL1(1), GSK3B(2), HDAC2(1), HDAC3(1), HDAC4(2), HDAC8(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), MPEG1(3), PLK1(1), PRKDC(12), PTPRA(2), PTTG2(2), RB1(16), RBL1(3), SKP2(1), TBC1D8(2), TFDP1(1), TP53(63), WEE1(2) 32928431 174 119 160 23 54 24 33 11 51 1 5.97e-05 0.998 1.000 255 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(6), MEF2A(2), MEF2C(1), MEF2D(1), MYOD1(3), YWHAH(1) 2526001 14 14 14 5 5 4 3 1 1 0 0.638 0.998 1.000 256 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IFNG(2), IL4(1), TGFB2(2), TGFB3(2), TGFBR1(1), TOB1(1) 3170549 9 9 9 3 3 0 5 0 1 0 0.750 0.998 1.000 257 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(1), INSR(6), JAK2(4), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SHC1(2), SLC2A4(1), SOS1(4), STAT5A(2), STAT5B(1) 9788207 40 34 39 7 24 5 2 2 7 0 0.0438 0.998 1.000 258 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(2), CPOX(1), EPRS(3), FECH(1), GUSB(3), HCCS(1), HMBS(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2B15(1), UGT2B4(4) 7995806 28 25 28 9 8 3 8 1 8 0 0.767 0.998 1.000 259 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1) 3918647 8 8 8 4 1 3 1 0 3 0 0.916 0.998 1.000 260 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), GPT(1), LDHA(1), MAPK14(2), NCL(1) 2675956 7 6 7 3 3 0 2 1 1 0 0.795 0.998 1.000 261 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), CAMP(1), CREB3(1), CREB5(1), MAPK1(1), RAF1(1), SNX13(2), SRC(1) 3399579 9 9 9 3 4 1 3 0 1 0 0.714 0.999 1.000 262 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(4), MAP2(5), PPP1CA(2), PPP2CA(1), PRKACB(1), PRKAR2B(1) 4928429 14 14 14 3 7 1 3 0 3 0 0.444 0.999 1.000 263 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(1), CTH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), SDS(2), SULT1C4(1) 3679992 8 8 8 3 3 2 0 1 2 0 0.750 0.999 1.000 264 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4(1), IL4R(1), JAK1(2), JAK3(3), RPS6KB1(1), SHC1(2), STAT6(1) 4322510 11 11 11 3 5 0 3 2 1 0 0.571 0.999 1.000 265 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(6), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), NME1(1), PRF1(3) 3124411 16 15 16 6 7 2 4 1 2 0 0.695 0.999 1.000 266 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(2), ADH1B(2), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(4), DCT(1), DDC(1), GSTZ1(1), HGD(1), HPD(2), MAOA(2), MAOB(2), TH(2), TPO(9), TYR(4) 9312601 40 37 40 8 19 7 9 1 4 0 0.0952 0.999 1.000 267 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAX(1), BCL10(1), BCL2(1), BID(1), CASP8AP2(3), CES1(1) 3424506 11 11 11 5 6 3 0 0 2 0 0.767 0.999 1.000 268 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(2), ASS1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), DAO(5), EPRS(3), GATM(1), GLUD1(2), GLUD2(3), LAP3(1), NOS1(9), NOS3(2), OAT(2), P4HA1(1), P4HA2(2), P4HA3(1), PARS2(1) 10937130 46 39 46 8 23 10 7 1 5 0 0.0370 0.999 1.000 269 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), FUT1(2), FUT9(2), GBGT1(1), GLA(1), HEXA(1), NAGA(2), ST3GAL1(1), ST8SIA1(1) 3079349 12 11 12 4 1 1 8 0 2 0 0.801 0.999 1.000 270 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(3), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2A1(2), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2) 7606465 23 21 23 8 8 4 3 1 7 0 0.830 0.999 1.000 271 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR161(3), GPR34(1), GPR45(1), GPR65(1), GPR68(1) 2856796 9 9 9 6 4 1 2 1 1 0 0.947 0.999 1.000 272 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1) 4451255 11 11 11 3 1 1 4 1 4 0 0.844 0.999 1.000 273 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1) 4451255 11 11 11 3 1 1 4 1 4 0 0.844 0.999 1.000 274 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1) 4451255 11 11 11 3 1 1 4 1 4 0 0.844 0.999 1.000 275 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(1), APOC3(1), CYP7A1(1), DGAT1(2), HMGCR(4), LDLR(1), LIPC(2), LPL(1), LRP1(12), SCARB1(1) 7940072 32 28 32 5 18 6 4 1 3 0 0.0571 0.999 1.000 276 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(3), AKT3(1), CISH(2), IARS(1), IL13RA1(2), IL4(1), IL4R(1), INPP5D(1), JAK1(2), JAK2(4), JAK3(3), NR0B2(2), PIK3CA(7), PPP1R13B(5), RPS6KB1(1), SHC1(2), SOS1(4), SOS2(2), SRC(1), STAT6(1), TYK2(2) 10833832 48 43 47 8 28 5 6 4 5 0 0.0298 0.999 1.000 277 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), CDK7(1), ERCC3(3), GTF2B(1), GTF2E1(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3B(1), POLR3D(1), POLR3E(1), TAF5(1) 10440897 24 23 24 4 10 4 2 1 7 0 0.160 0.999 1.000 278 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(2), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), RDH12(1), RDH13(1) 7175361 29 28 29 8 10 6 4 3 6 0 0.460 0.999 1.000 279 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), COASY(1), DPYD(3), ENPP3(1), PANK4(1), PPCS(1), UPB1(1) 4074560 10 10 10 3 7 2 1 0 0 0 0.520 0.999 1.000 280 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), FOS(2), INSR(6), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(4), SHC1(2), SLC2A4(1), SOS1(4) 7470481 33 29 32 7 18 4 3 2 6 0 0.156 0.999 1.000 281 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(1), FASN(10), PECR(2) 4488218 17 15 17 9 10 1 0 3 3 0 0.886 0.999 1.000 282 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACPP(4), ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), DHRS3(1), DHRS7(1), PON3(1) 5417451 20 19 20 7 7 2 4 3 4 0 0.761 0.999 1.000 283 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(2), F13A1(1), F2(1), FGA(6), PLAU(1), SERPINB2(1), SERPINE1(1) 3933839 13 13 13 5 8 2 1 0 2 0 0.639 0.999 1.000 284 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(2), ENPP3(1), NADSYN1(1) 4300366 8 7 8 2 5 0 1 2 0 0 0.542 0.999 1.000 285 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), FOS(2), JUN(1), MAP2K1(1), NGFR(1), PIK3CA(7), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(4) 5603454 25 24 24 6 15 2 3 1 4 0 0.302 0.999 1.000 286 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(4), CHST11(1), CHST12(1), CHST13(1), CHST3(3), CHST7(1), CHSY1(1), DSE(5), UST(1) 4033660 21 19 21 7 6 7 5 1 2 0 0.581 0.999 1.000 287 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(2), GUSB(3), HEXA(1), IDUA(2), LCT(4), NAGLU(1) 4270926 13 12 13 7 7 1 3 0 2 0 0.820 0.999 1.000 288 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDPS(1), HMGCR(4), HMGCS1(2), IDI1(1), LSS(1), MVK(1), NSDHL(1), PMVK(2), SQLE(1) 3902562 14 12 14 4 4 4 1 2 3 0 0.614 0.999 1.000 289 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2A(3), CAMK2B(1) 3492392 4 4 4 3 1 1 0 0 2 0 0.912 1.000 1.000 290 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(1), HK2(4), HK3(3), IMPA1(1), PGM3(2) 3089987 11 10 11 6 6 2 0 2 1 0 0.819 1.000 1.000 291 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), BDKRB2(3), NOS3(2) 2945175 7 6 7 3 3 1 2 1 0 0 0.732 1.000 1.000 292 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), LRP8(3), RELN(5), VLDLR(1) 4098742 10 10 10 9 3 1 3 1 2 0 0.991 1.000 1.000 293 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(3), AKT3(1), BCL2(1), GSK3B(2), IL4R(1), IRS2(1), JAK1(2), JAK3(3), MAP4K1(1), MAPK1(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(4), SOS2(2), STAT6(1) 10644364 44 40 43 9 26 4 3 4 7 0 0.0697 1.000 1.000 294 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD4(1), CXCR3(1), IFNG(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(3), TYK2(2) 4420412 26 25 26 7 12 4 6 1 3 0 0.374 1.000 1.000 295 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ICAM1(1), ITGAL(3), ITGAM(1), ITGB2(2), PECAM1(1), SELE(1), SELL(1) 3161303 11 9 11 4 7 2 1 0 1 0 0.582 1.000 1.000 296 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(1), CA12(1), CA4(2), CA6(1), CA8(1), CA9(2), CPS1(6), CTH(1), GLS(1), GLUD1(2), GLUL(1) 5517736 23 22 23 9 11 2 4 2 4 0 0.745 1.000 1.000 297 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), SDS(2) 3573992 15 10 15 5 6 4 3 1 1 0 0.622 1.000 1.000 298 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), ASAH1(1), CAMP(1), CREB3(1), CREB5(1), EPHB2(4), FOS(2), ITPKB(1), JUN(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1) 8340844 26 23 26 7 11 2 5 1 7 0 0.523 1.000 1.000 299 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), AXIN1(10), CCND2(1), CSNK1E(2), CTNNB1(52), DVL1(1), DVL2(4), FBXW2(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD5(1), FZD9(2), GSK3B(2), JUN(1), LDLR(1), MAPK10(3), MAPK9(1), MYC(1), PLAU(1), PPP2R5C(1), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(2), SFRP4(1), TCF7(3), WNT1(2), WNT2(1), WNT4(1), WNT6(2) 16788376 117 87 90 20 42 18 27 11 18 1 0.00917 1.000 1.000 300 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(2), BIRC2(1), BIRC3(1), CASP8(1), CFLAR(1), FADD(2), JUN(1), MAP2K4(3), MAP3K7(1), NFKB1(2), NFKBIA(2), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(2), TNF(2), TNFRSF1A(1) 8294071 25 25 25 9 11 4 2 1 7 0 0.752 1.000 1.000 301 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), CRY1(3), CSNK1E(2), NPAS2(4), NR1D1(1), PER1(2), PER2(4), PER3(1) 5015120 19 18 19 5 9 1 5 1 3 0 0.393 1.000 1.000 302 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(6), EP300(3), NCOA3(6), PRKACB(1), PRKAR2B(1), RARA(1), RXRA(5) 6067310 23 19 23 5 12 2 5 2 2 0 0.271 1.000 1.000 303 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(3), AKT3(1), BRD4(4), CBL(1), CDC42(2), CDKN2A(1), FLOT1(3), FLOT2(1), GSK3B(2), INPPL1(2), IRS2(1), IRS4(5), LNPEP(4), MAPK1(1), PARD3(4), PIK3CA(7), PIK3CD(4), PIK3R1(2), PPYR1(1), PTEN(7), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SERPINB6(2), SHC1(2), SLC2A4(1), SORBS1(2), SOS1(4), SOS2(2), YWHAE(2), YWHAH(1), YWHAZ(1) 17154583 85 69 84 13 44 11 12 4 14 0 0.00226 1.000 1.000 304 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), GNAS(7), GNB1(1), NFKB1(2), NOS3(2), NR3C1(2), PIK3CA(7), PIK3R1(2), RELA(1) 5359819 27 27 24 9 15 4 4 1 3 0 0.654 1.000 1.000 305 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(1), CHAT(4), DDC(1), GAD1(3), GAD2(1), HDC(2), MAOA(2), TH(2), TPH1(2) 4159826 20 19 20 7 11 2 4 1 2 0 0.550 1.000 1.000 306 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), GNA13(2), GNB1(1), PLCB1(5), PPP1R12B(1), PRKCA(1), ROCK1(3) 6086756 16 15 16 4 6 4 1 2 3 0 0.530 1.000 1.000 307 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), FOS(2), IL2RB(3), JAK1(2), JAK3(3), JUN(1), LCK(3), MAP2K1(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1), SYK(1) 7068414 27 23 27 5 15 3 5 2 2 0 0.133 1.000 1.000 308 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2) 5881360 15 15 15 7 7 3 1 0 4 0 0.749 1.000 1.000 309 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACPP(4), ACPT(1), ENPP3(1), FLAD1(3), LHPP(1), MTMR1(1), MTMR6(2), PHPT1(1), TYR(4) 4458857 19 17 19 7 8 2 5 2 2 0 0.765 1.000 1.000 310 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPNS1(1), CXCR3(1), EGF(4), EGFR(4), ITGA1(3), ITGB1(1), MAPK1(1), PRKACB(1), PRKAR2B(1), PTK2(6), PXN(1), TLN1(3) 9870847 28 27 28 5 11 3 8 1 5 0 0.182 1.000 1.000 311 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CXCR4(1), GNAI1(2), GNB1(1), MAP2K1(1), MAPK1(1), NFKB1(2), PIK3C2G(5), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(6), PTK2B(4), PXN(1), RAF1(1), RELA(1) 8303257 41 38 40 9 24 6 5 1 5 0 0.134 1.000 1.000 312 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(1), HK2(4), HK3(3), IMPA1(1), IMPA2(2), PGM3(2) 3494066 13 12 13 7 6 4 0 2 1 0 0.845 1.000 1.000 313 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), FOS(2), IGF1R(6), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4) 7259161 32 29 31 8 19 2 4 2 5 0 0.263 1.000 1.000 314 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(3), AKT3(1), BCR(1), BTK(1), CD19(1), CDKN2A(1), DAPP1(1), FLOT1(3), FLOT2(1), GAB1(4), ITPR1(6), ITPR2(3), ITPR3(8), LYN(1), NR0B2(2), PHF11(1), PIK3CA(7), PLCG2(5), PPP1R13B(5), PREX1(8), PTEN(7), PTPRC(4), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SAG(1), SYK(1), VAV1(3) 16350181 90 71 89 13 45 18 14 2 11 0 0.000989 1.000 1.000 315 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), COPS5(1), EDN1(2), EP300(3), HIF1A(1), JUN(1), LDHA(1), NOS3(2), P4HB(1) 4987132 14 13 14 4 7 0 6 1 0 0 0.503 1.000 1.000 316 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(7), GNB1(1), PPP2CA(1), PRKAA1(3), PRKAB2(1), PRKACB(1), PRKAG2(1), PRKAR2B(1) 4544761 19 18 17 6 10 4 3 0 2 0 0.598 1.000 1.000 317 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), PLCG1(3), PTPN6(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1) 6470624 23 21 23 5 14 1 2 2 4 0 0.286 1.000 1.000 318 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), EPX(2), ESCO1(2), ESCO2(2), HPD(2), LPO(3), MAOA(2), MAOB(2), MPO(5), PNPLA3(1), SH3GLB1(1), TPO(9) 9957420 39 33 39 8 18 7 8 0 6 0 0.0963 1.000 1.000 319 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), DPYD(3), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), HIBCH(4), SRM(2), UPB1(1) 7844069 33 28 33 7 16 6 5 4 2 0 0.130 1.000 1.000 320 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(1), ITGB2(2), PECAM1(1), SELE(1), SELL(1) 3604557 13 12 13 5 7 2 1 2 1 0 0.675 1.000 1.000 321 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(1), ACADVL(1), ACSL1(1), CPT1A(3), EHHADH(9), PECR(2) 4912783 18 11 18 7 7 6 2 1 2 0 0.795 1.000 1.000 322 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(3), AKT3(1), CAB39(1), HIF1A(1), MAPK1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PRKAA1(3), RICTOR(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), TSC1(7), TSC2(9), ULK1(1), ULK2(6), VEGFC(3) 15924968 76 58 75 10 37 10 8 2 19 0 0.00211 1.000 1.000 323 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(3), CCNB1(1), GNAI1(2), GNAS(7), GNB1(1), MAPK1(1), MYT1(4), PIN1(1), PRKACB(1), PRKAR2B(1), RPS6KA1(1), SRC(1) 6074458 24 23 22 5 10 7 5 0 2 0 0.271 1.000 1.000 324 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(2) 3673005 9 9 9 5 3 0 3 2 1 0 0.932 1.000 1.000 325 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD5(1), IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL4(1), ITGAX(1), TLR2(1), TLR4(2), TLR7(2), TLR9(2) 5456072 21 19 21 5 6 2 7 3 3 0 0.351 1.000 1.000 326 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), ASRGL1(1), CA1(1), CA12(1), CA4(2), CA6(1), CA8(1), CA9(2), CPS1(6), CTH(1), GLS(1), GLUD1(2), GLUD2(3), GLUL(1) 6163092 27 26 27 9 14 2 5 2 4 0 0.566 1.000 1.000 327 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(3), C6(1), C7(1), ICAM1(1), IL6(2), ITGA4(2), ITGAL(3), ITGB1(1), ITGB2(2), SELP(1), TNF(2), VCAM1(1) 7291166 28 25 28 9 12 1 7 3 5 0 0.607 1.000 1.000 328 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), ARG1(2), ASS1(2), CPS1(6), GATM(1), MAOA(2), MAOB(2), NAGS(1), ODC1(1), SRM(2) 8669754 30 26 30 6 12 7 6 1 4 0 0.189 1.000 1.000 329 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ANPEP(2), CTSG(1), ENPEP(1), LNPEP(4), MME(5), THOP1(1) 6193306 16 13 16 5 6 1 2 3 4 0 0.638 1.000 1.000 330 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(4), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), RPS6KA1(1), SHC1(2) 5843622 26 25 25 7 15 4 3 1 3 0 0.351 1.000 1.000 331 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR24(1), FDPS(1), GGPS1(1), HMGCR(4), IDI1(1), LSS(1), MVK(1), NSDHL(1), PMVK(2), SQLE(1) 5733388 14 11 14 5 4 3 1 2 4 0 0.701 1.000 1.000 332 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(2), ABCG2(2), BCHE(1), CES1(1), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1) 6761514 17 16 17 5 9 1 2 1 4 0 0.460 1.000 1.000 333 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(2), CTH(1), HEMK1(2), LCMT1(1), LCMT2(3), MARS(3), MARS2(1), MAT1A(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), SCLY(2), SEPHS1(1), SEPHS2(1) 7315632 28 23 28 6 13 7 3 3 2 0 0.269 1.000 1.000 334 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), AMT(1), FTCD(2), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2) 5631919 12 11 12 4 5 2 2 0 3 0 0.662 1.000 1.000 335 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(3), ACTN2(2), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(1), CAV1(1), FYN(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), PPP1R12B(1), PTK2(6), PXN(1), RAF1(1), RAP1A(1), ROCK1(3), SHC1(2), SOS1(4), SRC(1), TLN1(3), VCL(3), ZYX(1) 13975262 48 35 48 8 24 10 7 4 3 0 0.0383 1.000 1.000 336 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(1), GNE(1), HEXA(1), HK1(1), HK2(4), HK3(3), PGM3(2) 5054845 14 12 14 8 7 2 1 2 2 0 0.886 1.000 1.000 337 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(2), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(3), RPS6KA1(1), RPS6KA3(6), SHC1(2), SOS1(4), SYK(1), VAV1(3), VAV2(1), VAV3(4) 9430943 37 34 37 7 20 5 8 2 2 0 0.0809 1.000 1.000 338 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), CD36(1), CITED2(1), CPT1B(3), CREBBP(6), DUSP1(1), EHHADH(9), EP300(3), FABP1(1), JUN(1), LPL(1), MAPK1(1), MRPL11(1), MYC(1), NCOA1(2), NCOR1(2), NCOR2(6), NFKBIA(2), NR0B2(2), NR1H3(2), PDGFA(1), PIK3CA(7), PIK3R1(2), PPARA(2), PRKACB(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(16), RELA(1), RXRA(5), SP1(2), STAT5A(2), STAT5B(1), TNF(2) 18835439 93 68 92 13 39 10 14 7 22 1 0.00672 1.000 1.000 339 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(6), CR2(5), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4) 5004576 22 22 22 7 11 2 6 1 2 0 0.525 1.000 1.000 340 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(6), EP300(3), FYN(1), IL7(1), IL7R(1), JAK1(2), JAK3(3), LCK(3), NMI(2), PIK3CA(7), PIK3R1(2), PTK2B(4), STAT5A(2), STAT5B(1) 8281872 39 35 38 9 19 6 7 2 5 0 0.190 1.000 1.000 341 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(1), ASAH1(1), GALC(3), GLA(1), GLB1(2), LCT(4), NEU1(3), NEU2(3), NEU3(2), PPAP2A(3), PPAP2C(3), SMPD2(2), SPTLC2(2) 7109705 31 28 31 7 19 2 7 0 3 0 0.151 1.000 1.000 342 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL4(1), IL6(2), IL7(1), LTA(1), PDGFA(1), TGFB2(2), TGFB3(2), TNF(2) 4038854 22 22 22 6 8 3 9 1 1 0 0.437 1.000 1.000 343 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B4GALT2(1), B4GALT3(2), FUT1(2), FUT3(1), FUT9(2), GCNT2(1), ST3GAL6(1), ST8SIA1(1) 4602203 12 10 12 5 1 3 5 1 2 0 0.907 1.000 1.000 344 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(2), GUSB(3), HEXA(1), HGSNAT(2), HPSE(1), HPSE2(1), HYAL1(1), IDUA(2), LCT(4), NAGLU(1), SPAM1(3) 6156795 21 20 21 9 10 3 5 0 3 0 0.750 1.000 1.000 345 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACAT2(4), DHRS3(1), DHRS7(1), ECHS1(1), EHHADH(9), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 7544037 23 18 23 5 10 4 6 1 2 0 0.220 1.000 1.000 346 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD4(1), CREBBP(6), GNAS(7), GNB1(1), LCK(3), PRKACB(1), PRKAR2B(1), PTPRC(4), ZAP70(1) 6763993 28 24 26 6 13 6 7 0 2 0 0.280 1.000 1.000 347 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD4(1), CREBBP(6), GNAS(7), GNB1(1), LCK(3), PRKACB(1), PRKAR2B(1), PTPRC(4), ZAP70(1) 6763993 28 24 26 6 13 6 7 0 2 0 0.280 1.000 1.000 348 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(2), ARSD(1), CYP11B1(1), CYP11B2(6), HSD17B3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2B15(1), UGT2B4(4) 8003615 22 21 22 7 11 3 2 1 5 0 0.613 1.000 1.000 349 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(2), JUN(1), MAP2K1(1), MAPK1(1), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(5), PRKCA(1), RAF1(1), RELA(1), TNF(2) 4502795 22 21 22 7 14 2 5 0 1 0 0.474 1.000 1.000 350 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(1), MAP2K4(3), MAP3K1(2), MAP4K2(1), MAPK14(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1) 7342117 26 25 26 6 13 4 5 0 4 0 0.336 1.000 1.000 351 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), GLB1(2), HEXA(1), LCT(4), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(2), ST8SIA1(1) 4787287 16 15 16 5 11 0 4 0 1 0 0.425 1.000 1.000 352 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(2), IFNG(2), IKBKB(3), IL4(1), JUN(1), MAP3K1(2), MAP3K5(2), MAP4K5(3), MAPK14(2), NFKB1(2), NFKBIA(2), RELA(1) 5819879 23 22 23 7 12 3 6 0 2 0 0.508 1.000 1.000 353 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(3), PLCB1(5), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(1), PRKAR2B(1) 4703206 19 16 19 6 12 3 3 0 1 0 0.468 1.000 1.000 354 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(2), ALOX5(2), LTA4H(1), PLA2G6(1), PTGES(1), PTGS1(1), PTGS2(1), TBXAS1(1) 4593030 10 10 10 7 4 2 1 2 1 0 0.972 1.000 1.000 355 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC1(1), ANAPC5(1), ANAPC7(1), ATM(7), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDC14B(2), CDC27(1), CDC7(3), CDK7(1), CDKN1A(5), CDKN2A(1), CHEK1(1), CHEK2(2), CREBBP(6), CUL1(1), E2F1(1), E2F3(2), EP300(3), ESPL1(1), FZR1(2), GSK3B(2), HDAC2(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), PKMYT1(1), PLK1(1), PRKDC(12), PTTG2(2), RB1(16), RBL1(3), RBL2(5), SKP2(1), SMAD3(2), SMC1A(1), SMC1B(1), TFDP1(1), TGFB2(2), TGFB3(2), TP53(63), WEE1(2), YWHAE(2), YWHAH(1), YWHAZ(1) 40482195 195 125 181 25 61 31 37 14 51 1 2.59e-05 1.000 1.000 356 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 CREB3(1), CREB5(1), DUSP6(3), DUSP9(1), EEF2K(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MKNK1(1), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), SHC1(2), SOS1(4), SOS2(2) 8785471 35 29 35 7 23 5 4 1 2 0 0.0592 1.000 1.000 357 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ADH1A(2), ADH1B(2), ADH5(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 7252042 15 15 15 4 6 3 2 0 4 0 0.486 1.000 1.000 358 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 BAIAP2(1), CASP7(1), CASP8(1), INSR(6), MAGI1(1), MAGI2(5), WWP2(2) 6903469 17 15 17 6 7 3 2 2 3 0 0.650 1.000 1.000 359 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), PECAM1(1), SELE(1), SELL(1), SELP(1) 4797194 15 12 15 6 8 2 2 2 1 0 0.690 1.000 1.000 360 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA4(2), PSMA7(3), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(6), PSMD13(2), PSMD2(1) 4729783 20 17 20 5 9 5 5 1 0 0 0.346 1.000 1.000 361 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), GOSR2(3), SNAP25(1), SNAP29(1), STX10(1), STX12(1), STX16(1), STX19(2), STX2(1), STX6(1), TSNARE1(1), USE1(1), VAMP1(1), VAMP3(1) 4998913 17 17 17 9 7 3 4 2 1 0 0.916 1.000 1.000 362 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), FYN(1), GSN(1), ITGA1(3), ITGB1(1), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), PTK2(6), PXN(1), RAF1(1), ROCK1(3), SHC1(2), SRC(1), TLN1(3) 11101529 36 33 35 7 17 5 5 4 5 0 0.158 1.000 1.000 363 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(1), HS2ST1(2), NDST1(1), NDST2(2), NDST3(1), NDST4(6) 6152795 18 15 18 9 9 2 3 2 2 0 0.840 1.000 1.000 364 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(2), BECN1(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNG(2), PIK3R4(2), PRKAA1(3), ULK1(1), ULK2(6) 6339728 30 25 30 8 12 5 7 4 2 0 0.395 1.000 1.000 365 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), FPGT(2), GMPPA(3), HK1(1), HK2(4), HK3(3), MPI(1), PFKFB1(3), PFKFB3(2), PFKP(2), PMM1(1), SORD(1) 7146160 25 23 25 7 14 6 0 2 3 0 0.304 1.000 1.000 366 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), GPT(1), ME2(1), ME3(1) 5319012 5 5 5 4 1 1 2 0 1 0 0.969 1.000 1.000 367 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(4), ADRBK2(1), ARRB2(1), CAMK2A(3), CAMK2B(1), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(6), CNGA4(2), CNGB1(1), GNAL(2), GUCA1B(1), PDE1C(5), PRKACA(1), PRKACB(1), PRKG1(4), PRKX(2) 9157508 43 33 43 9 19 14 5 0 5 0 0.143 1.000 1.000 368 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNB1(1), IKBKB(3), IL1B(1), IL1R1(3), IL6(2), IRAK1(2), IRAK3(3), JUN(1), MAP3K1(2), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(2), TNF(2), TRAF6(1) 8737181 36 33 36 8 18 4 10 1 3 0 0.182 1.000 1.000 369 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1R(1), C1S(1), C2(1), C3(8), C4A(1), C5(3), C6(1), C7(1), C9(2) 9191871 21 19 21 8 8 2 3 3 5 0 0.779 1.000 1.000 370 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), AMT(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2) 5256640 10 9 10 4 5 2 2 0 1 0 0.662 1.000 1.000 371 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), GORASP1(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKB1(2), NFKBIA(2), NFKBIL1(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), TRAF5(1), TRAF6(1) 10445897 35 33 34 9 20 3 4 2 6 0 0.290 1.000 1.000 372 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), COASY(1), DPYD(3), ENPP3(1), PANK4(1), PPCS(1), UPB1(1) 5074800 11 11 11 4 7 2 2 0 0 0 0.658 1.000 1.000 373 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BCL2(1), BID(1), BIRC2(1), BIRC3(1), CASP10(1), CASP6(1), CASP7(1), CASP8(1), CFLAR(1), CHUK(2), DFFB(1), FADD(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), SPTAN1(4), TNFRSF25(1) 9854953 32 29 32 9 14 8 4 1 5 0 0.437 1.000 1.000 374 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(1), IARS2(2), PDHA1(1), PDHA2(3), PDHB(1) 5465959 11 11 11 6 6 2 2 0 1 0 0.888 1.000 1.000 375 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(2), NFKB1(2), NFKBIA(2), RELA(1), TRAF6(1) 5614978 16 16 16 7 8 2 4 1 1 0 0.801 1.000 1.000 376 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(2), AP2M1(1), BIN1(2), EPS15(1), NME1(1), PPP3CA(4), SYNJ1(3), SYNJ2(1) 6673355 19 17 19 6 9 6 1 1 2 0 0.484 1.000 1.000 377 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(2), GPX1(1), GSTA2(1), GSTA4(1), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(3), IDH2(4), PGD(1) 5673037 17 16 15 5 8 2 4 2 1 0 0.491 1.000 1.000 378 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPNS1(1), EP300(3), HDAC2(1), MEF2D(1), NFATC2(3), PPP3CA(4), PRKCA(1) 7052228 19 17 19 5 11 0 5 1 2 0 0.295 1.000 1.000 379 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), GPT(1), ME3(1), PGK2(2), TKTL1(2), TKTL2(3) 5936993 11 11 11 4 3 3 4 0 1 0 0.739 1.000 1.000 380 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2A(3), CAMK2B(1), ESRRA(1), MEF2A(2), MEF2C(1), MEF2D(1), PPARA(2), PPP3CA(4), SLC2A4(1), YWHAH(1) 6245869 17 16 17 6 6 6 1 2 2 0 0.606 1.000 1.000 381 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 EGFR(4), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAPK1(1), MEF2A(2), MEF2C(1), MEF2D(1), PAK1(1), PRKCA(1), PTK2(6), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), SRC(1) 10070090 38 35 38 9 20 3 9 1 5 0 0.257 1.000 1.000 382 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2B(1), GTF2E1(1), GTF2IRD1(1), STON1(2), TAF1(6), TAF1L(3), TAF2(2), TAF4B(2), TAF5(1), TAF6L(1), TAF7L(1), TAF9B(1), TBPL1(2), TBPL2(1) 10975808 25 22 25 7 14 2 3 0 5 1 0.445 1.000 1.000 383 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2A(3), CAMK2B(1), F2(1), FYN(1), GNAI1(2), GNB1(1), JAK2(4), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK14(2), MAPT(3), PLCG1(3), PRKCA(1), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2) 12530357 44 38 44 9 25 2 7 3 7 0 0.0765 1.000 1.000 384 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1R(1), C1S(1), C2(1), C3(8), C4A(1), C5(3), C6(1), C7(1), C8B(1), C9(2) 10153955 22 20 22 9 9 2 3 3 5 0 0.812 1.000 1.000 385 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(2), AKR1D1(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), BAAT(1), CEL(1), CYP27A1(3), CYP7A1(1), HADHB(1), SOAT2(1) 6810986 18 18 18 5 10 5 1 0 2 0 0.390 1.000 1.000 386 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AP2A1(2), AP2M1(1), BTK(1), EEA1(2), GSK3B(2), LYN(1), PFKL(1), PFKP(2), PLCG1(3), PRKCZ(1), RPS6KB1(1), VAV2(1) 7236747 18 17 18 8 9 3 2 2 2 0 0.797 1.000 1.000 387 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(2), ENPP3(1), NADSYN1(1), NMNAT3(1), NT5C1B(1), NT5C2(1), NUDT12(1) 6328678 13 12 13 5 8 0 2 2 1 0 0.641 1.000 1.000 388 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(2), AOC2(2), AOC3(1), CES1(1), DDHD1(2), ESCO1(2), ESCO2(2), LIPA(2), PNPLA3(1), SH3GLB1(1) 7432758 19 16 19 6 7 5 5 0 2 0 0.514 1.000 1.000 389 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH5(1), AKR1D1(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(3), CYP7A1(1), HADHB(1), HSD3B7(1), LIPA(2), RDH12(1), RDH13(1), SOAT2(1) 9363823 26 25 26 7 14 6 2 0 4 0 0.322 1.000 1.000 390 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADL(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), DPYD(3), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), SDS(2), UPB1(1) 8434888 30 25 30 9 15 6 5 2 2 0 0.444 1.000 1.000 391 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4) 7580532 20 17 20 9 8 4 3 2 3 0 0.855 1.000 1.000 392 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4), P4HB(1), SLC23A2(2), SLC2A3(1) 7614741 24 19 24 9 10 5 4 2 3 0 0.735 1.000 1.000 393 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), NFAT5(4), PDE6A(3), PDE6B(3), SLC6A13(2), TF(1) 10740624 35 31 35 8 17 7 3 2 6 0 0.230 1.000 1.000 394 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), DUSP1(1), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TRAF1(1) 6834268 19 19 19 6 10 2 5 1 1 0 0.545 1.000 1.000 395 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), MAP3K1(2), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLD1(2), PPP1R12B(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(3) 10324424 28 27 27 9 13 4 5 2 4 0 0.504 1.000 1.000 396 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(2), GPX1(1), GSR(2), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(3), IDH2(4), OPLAH(3) 6906765 22 19 20 7 11 4 4 2 1 0 0.497 1.000 1.000 397 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(1), GNAI1(2), GNB1(1), ITGA1(3), ITGB1(1), MAP2K1(1), MAPK1(1), PLA2G4A(5), PLCB1(5), PRKCA(1), PTGS1(1), PTK2(6), RAF1(1), SRC(1), SYK(1), TBXAS1(1) 7147151 33 30 33 9 16 7 7 2 1 0 0.409 1.000 1.000 398 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), HARS(1), HDC(2), MAOA(2), MAOB(2), PRPS2(1) 7180267 18 14 18 6 8 3 6 0 1 0 0.570 1.000 1.000 399 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(1), BAX(1), BTK(1), CAD(2), CASP10(1), CASP8(1), CASP8AP2(3), DEDD2(1), EGFR(4), EPHB2(4), FADD(2), FAF1(2), FAIM2(1), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIL1(1), NR0B2(2), PTPN13(11), RALBP1(1), RIPK1(2), ROCK1(3), TNFRSF6B(1), TP53(63), TPX2(2) 22002886 131 99 118 24 51 26 13 5 36 0 0.0127 1.000 1.000 400 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(3), DIAPH2(1), GMNN(1), MCM10(4), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), NACA(2), POLA2(1), POLD1(2), POLE(3), POLE2(2), RFC1(3), RFC3(1), RFC4(1), RFC5(2), RPS27A(1), UBC(1) 15003830 37 31 37 7 15 8 10 3 1 0 0.121 1.000 1.000 401 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(2), FADD(2), IKBKB(3), IL1R1(3), IRAK1(2), MAP3K1(2), MAP3K7(1), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TLR4(2), TNF(2), TNFRSF1A(1), TRAF6(1) 7381095 29 28 29 8 16 5 7 0 1 0 0.356 1.000 1.000 402 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ACY3(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDH7A1(1), AMDHD1(1), AOC2(2), AOC3(1), DDC(1), FTCD(2), HARS(1), HARS2(1), HDC(2), HEMK1(2), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), PRPS2(1), UROC1(2) 11669126 39 27 39 9 20 6 8 1 4 0 0.206 1.000 1.000 403 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(5), AR(2), ASAH1(1), CAMP(1), CCL13(1), CCL15(1), EGFR(4), GNA15(1), GNAI1(2), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), MAPK10(3), MAPK14(2), PHKA2(2), PIK3CA(7), PIK3CD(4), PIK3R1(2), PTX3(1), RAF1(1), SRC(1) 15942728 61 50 60 11 33 8 10 2 8 0 0.0313 1.000 1.000 404 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(3), GARS(1), HARS(1), IARS(1), MARS(3), MARS2(1), SARS(1), TARS(1) 9346326 12 10 12 6 4 3 1 2 2 0 0.828 1.000 1.000 405 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(3), ACTN2(2), CAPN1(1), CAPNS1(1), ITGA1(3), ITGB1(1), PTK2(6), PXN(1), SPTAN1(4), SRC(1), TLN1(3) 8511117 26 22 26 7 11 9 4 1 1 0 0.434 1.000 1.000 406 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(4), ADCY9(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1D(1), ATP6V1F(2), GNAS(7), PLCG1(3), PLCG2(5), PRKCA(1) 10962943 35 32 33 9 16 11 4 0 4 0 0.365 1.000 1.000 407 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CYP2C9(1), DHRS3(1), DHRS7(1), ECHS1(1), EHHADH(9), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1) 9013995 22 17 22 7 9 6 5 1 1 0 0.481 1.000 1.000 408 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(3), AKT3(1), BCL2(1), BCR(1), BLNK(2), BTK(1), CD19(1), CD22(3), CD81(1), CR2(5), FLOT1(3), FLOT2(1), GSK3B(2), INPP5D(1), ITPR1(6), ITPR2(3), ITPR3(8), LYN(1), MAP4K1(1), MAPK1(1), NFATC2(3), NR0B2(2), PIK3CA(7), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), PPP3CA(4), PTPRC(4), RAF1(1), SHC1(2), SOS1(4), SOS2(2), SYK(1), VAV1(3) 21644038 95 77 94 17 54 15 13 5 8 0 0.00401 1.000 1.000 409 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(3), BMP7(2), BTRC(1), CSNK1A1L(3), CSNK1E(2), CSNK1G1(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(10), GLI3(6), GSK3B(2), HHIP(4), LRP2(12), PRKACA(1), PRKACB(1), PRKX(2), PTCH1(1), PTCH2(3), RAB23(1), STK36(1), SUFU(3), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1) 17483490 73 60 73 14 35 15 14 2 7 0 0.0299 1.000 1.000 410 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 CABIN1(5), IGF1R(6), INSR(6), MAPK14(2), MAPK7(4), MEF2A(2), MEF2C(1), MEF2D(1), MYOD1(3), NFATC2(3), PIK3CA(7), PIK3R1(2), PPP3CA(4), YWHAH(1) 10189356 47 37 46 10 28 6 7 2 4 0 0.0562 1.000 1.000 411 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(4), CDC42(2), CDH1(2), CLDN1(1), CTNNB1(52), CTTN(2), EZR(2), FYN(1), ITGB1(1), KRT18(1), LY96(1), NCL(1), OCLN(1), PRKCA(1), ROCK1(3), ROCK2(3), TLR4(2), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(2), WAS(1), WASL(1), YWHAZ(1) 15418637 102 79 75 21 39 11 33 10 8 1 0.0848 1.000 1.000 412 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(4), CDC42(2), CDH1(2), CLDN1(1), CTNNB1(52), CTTN(2), EZR(2), FYN(1), ITGB1(1), KRT18(1), LY96(1), NCL(1), OCLN(1), PRKCA(1), ROCK1(3), ROCK2(3), TLR4(2), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(2), WAS(1), WASL(1), YWHAZ(1) 15418637 102 79 75 21 39 11 33 10 8 1 0.0848 1.000 1.000 413 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(1), ARHGEF11(1), ARHGEF5(1), ARPC1A(1), ARPC1B(1), ARPC2(1), BAIAP2(1), CFL1(1), GSN(1), PIP5K1B(1), PPP1R12B(1), ROCK1(3), SRC(1), TLN1(3), VCL(3) 14113691 25 20 25 8 10 5 3 3 4 0 0.693 1.000 1.000 414 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(1), CAMP(1), CREB3(1), CREB5(1), CREBBP(6), JUN(1), MAP1B(7), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), NTRK1(2), PIK3C2G(5), PIK3CA(7), PIK3CD(4), PIK3R1(2), PTPN11(1), RPS6KA3(6), SHC1(2), SRC(1), TH(2) 15426918 59 49 58 12 34 6 8 3 8 0 0.0501 1.000 1.000 415 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(4), GNAS(7), GNB1(1), IGF1R(6), ITGB1(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(4), PPP2CA(1), PTPRR(1), RAF1(1), RPS6KA1(1), RPS6KA5(1), SHC1(2), SOS1(4), SRC(1), STAT3(3) 9878130 46 38 44 10 26 2 12 4 2 0 0.128 1.000 1.000 416 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(3), AKT3(1), CDC42(2), CDKN2A(1), CREB3(1), CREB5(1), ERBB4(4), GAB1(4), GSK3B(2), INPPL1(2), IRS2(1), IRS4(5), MYC(1), NOLC1(2), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PARD3(4), PIK3CA(7), PIK3CD(4), PPP1R13B(5), PREX1(8), PTEN(7), PTK2(6), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(4), SOS2(2), TSC1(7), TSC2(9), YWHAE(2), YWHAH(1), YWHAZ(1) 22383089 125 80 124 24 59 18 18 6 24 0 0.00534 1.000 1.000 417 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ASAH1(1), B4GALT6(2), DEGS1(2), GALC(3), GLA(1), GLB1(2), LCT(4), NEU1(3), NEU2(3), NEU3(2), PPAP2A(3), PPAP2C(3), SGPP1(1), SGPP2(1), SMPD2(2), SMPD4(2), SPHK1(2), SPHK2(1), SPTLC2(2), UGT8(1) 10461594 43 38 43 10 27 3 9 0 4 0 0.106 1.000 1.000 418 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(1), ACOX1(2), ACOX2(3), ACOX3(1), ACSL1(1), ACSL5(1), ACSL6(1), APOC3(1), CD36(1), CPT1A(3), CPT1B(3), CPT1C(2), CYP27A1(3), CYP4A11(1), CYP4A22(2), CYP7A1(1), CYP8B1(2), EHHADH(9), FABP1(1), GK2(2), LPL(1), NR1H3(2), PCK1(5), PLTP(1), PPARA(2), PPARD(1), RXRA(5), RXRB(2), RXRG(1), SLC27A2(1), SLC27A6(3), SORBS1(2), UBC(1), UCP1(2) 19298555 71 52 71 15 36 11 11 5 8 0 0.0522 1.000 1.000 419 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), AGMAT(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), ARG1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), DAO(5), GATM(1), GLUD1(2), MAOA(2), MAOB(2), NOS1(9), NOS3(2), OAT(2), ODC1(1), P4HA1(1), P4HA2(2), P4HA3(1), P4HB(1) 13280513 51 41 51 11 24 11 10 1 5 0 0.110 1.000 1.000 420 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(1), ACTN1(3), ACTN2(2), AKT2(3), AKT3(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), CAV1(1), CAV2(1), CCND2(1), CDC42(2), COL11A1(9), COL11A2(1), COL1A1(1), COL1A2(2), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), CTNNB1(52), DOCK1(6), EGF(4), EGFR(4), FARP2(2), FLNA(4), FLNB(5), FLNC(3), FLT1(4), FN1(7), FYN(1), GSK3B(2), HGF(5), IBSP(2), IGF1R(6), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(5), ITGB1(1), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), JUN(1), KDR(8), LAMA1(11), LAMA2(5), LAMA3(6), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(3), MAP2K1(1), MAPK1(1), MAPK10(3), MAPK9(1), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDGFA(1), PDGFB(1), PDGFC(1), PDGFD(2), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PRKCA(1), PRKCG(1), PTEN(7), PTK2(6), PXN(1), RAC2(1), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(5), ROCK1(3), ROCK2(3), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SPP1(1), SRC(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TLN1(3), TLN2(2), TNC(4), TNN(5), TNR(3), TNXB(8), VASP(1), VAV1(3), VAV2(1), VAV3(4), VCL(3), VEGFC(3), VTN(1), VWF(5), ZYX(1) 111262789 481 160 452 133 203 76 108 28 64 2 0.0673 1.000 1.000 421 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(1), ACVR1C(1), AKT2(3), AKT3(1), ARRB1(1), ARRB2(1), BDNF(1), CACNA1A(6), CACNA1B(6), CACNA1C(4), CACNA1D(3), CACNA1E(18), CACNA1F(1), CACNA1G(1), CACNA1H(5), CACNA1I(2), CACNA1S(2), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNA2D4(6), CACNB1(1), CACNB4(3), CACNG1(1), CACNG2(4), CACNG3(1), CACNG4(2), CACNG7(1), CDC42(2), CHUK(2), DDIT3(1), DUSP1(1), DUSP14(1), DUSP2(1), DUSP6(3), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(4), ELK4(2), FASLG(1), FGF11(1), FGF13(1), FGF14(1), FGF20(1), FGF3(1), FGF6(2), FGFR2(3), FGFR3(1), FGFR4(1), FLNA(4), FLNB(5), FLNC(3), FOS(2), GNG12(1), IKBKB(3), IL1B(1), IL1R1(3), JUN(1), JUND(1), KRAS(4), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(3), MAPK14(2), MAPK7(4), MAPK8IP3(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAPT(3), MEF2C(1), MKNK1(1), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(6), NFATC2(3), NFATC4(4), NFKB1(2), NLK(1), NR4A1(2), NRAS(1), NTRK1(2), NTRK2(2), PAK1(1), PDGFA(1), PDGFB(1), PDGFRA(4), PDGFRB(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PPM1B(1), PPP3CA(4), PPP5C(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PTPN5(2), PTPRR(1), RAC2(1), RAF1(1), RAP1A(1), RAPGEF2(4), RASA1(4), RASGRF1(5), RASGRF2(3), RASGRP1(3), RASGRP2(2), RASGRP4(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KA5(1), RPS6KA6(5), SOS1(4), SOS2(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(2), TAOK3(2), TGFB2(2), TGFB3(2), TGFBR1(1), TNF(2), TNFRSF1A(1), TP53(63), TRAF6(1), ZAK(1) 87663219 391 156 378 98 178 64 68 17 64 0 0.00326 1.000 1.000 422 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY7(1), ADCY8(5), ADCY9(1), ADORA2A(1), ADORA2B(2), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), ATP2A1(1), ATP2A3(1), ATP2B1(1), ATP2B2(4), ATP2B4(4), AVPR1B(1), BDKRB2(3), BST1(1), CACNA1A(6), CACNA1B(6), CACNA1C(4), CACNA1D(3), CACNA1E(18), CACNA1F(1), CACNA1G(1), CACNA1H(5), CACNA1I(2), CACNA1S(2), CAMK2A(3), CAMK2B(1), CCKBR(3), CD38(2), CHRM2(4), CHRM3(3), CHRM5(2), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRA(3), EDNRB(1), EGFR(4), ERBB3(6), ERBB4(4), GNA15(1), GNAL(2), GNAS(7), GRIN1(3), GRIN2A(2), GRIN2D(1), GRM1(3), GRM5(3), HRH2(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), LHCGR(4), MYLK2(1), NOS1(9), NOS3(2), OXTR(1), P2RX1(1), P2RX3(1), PDE1A(1), PDE1B(1), PDE1C(5), PDGFRA(4), PDGFRB(1), PHKA1(2), PHKA2(2), PHKB(5), PHKG2(3), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), PPP3CA(4), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PTGER3(2), PTK2B(4), RYR1(9), RYR2(24), RYR3(13), SLC25A5(1), SLC8A1(4), SLC8A2(1), SPHK1(2), SPHK2(1), TACR1(2), TACR2(2), TACR3(4), TNNC2(1), TRHR(4), TRPC1(2) 82069367 350 150 348 125 153 75 67 17 38 0 0.729 1.000 1.000 423 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 145 APC(5), APC2(2), AXIN1(10), AXIN2(3), BTRC(1), CAMK2A(3), CAMK2B(1), CCND2(1), CER1(2), CHD8(3), CREBBP(6), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CTBP2(2), CTNNB1(52), CUL1(1), DAAM1(2), DAAM2(1), DKK1(1), DKK2(2), DVL1(1), DVL2(4), EP300(3), FBXW11(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(1), FZD5(1), FZD9(2), GSK3B(2), JUN(1), LEF1(2), LRP5(2), LRP6(1), MAP3K7(1), MAPK10(3), MAPK9(1), MMP7(2), MYC(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NKD1(1), NKD2(1), NLK(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2B(1), PPP2R2C(2), PPP3CA(4), PRICKLE1(4), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PSEN1(1), RAC2(1), ROCK1(3), ROCK2(3), SENP2(4), SFRP2(1), SFRP4(1), SIAH1(4), SMAD3(2), TBL1XR1(1), TBL1Y(1), TCF7(3), TCF7L1(3), TCF7L2(2), TP53(63), VANGL2(1), WIF1(1), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1) 47325061 304 141 264 49 113 48 58 20 64 1 9.43e-06 1.000 1.000 424 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(1), ADORA2A(1), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA1B(1), ADRB2(3), AVPR1B(1), BDKRB2(3), C3AR1(1), CALCR(1), CCKBR(3), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CNR1(2), CNR2(1), CRHR1(3), CRHR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), DRD5(2), EDNRA(3), EDNRB(1), F2(1), F2RL3(1), FPR1(1), GABBR1(5), GABBR2(1), GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3), GABRB1(1), GABRB3(1), GABRG1(4), GABRG2(2), GABRG3(2), GABRQ(4), GABRR1(1), GABRR2(2), GALR1(1), GH1(1), GH2(4), GHR(1), GHSR(2), GLP1R(2), GLP2R(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(1), GPR156(1), GPR35(1), GPR50(2), GPR63(4), GPR83(1), GRIA1(5), GRIA2(7), GRIA3(5), GRIA4(7), GRID1(1), GRID2(2), GRIK1(1), GRIK2(3), GRIK3(2), GRIK4(2), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), GRIN3A(3), GRIN3B(3), GRM1(3), GRM2(2), GRM3(5), GRM4(2), GRM5(3), GRM6(2), GRM7(3), GRM8(5), GZMA(1), HCRTR1(1), HRH2(1), HRH3(2), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), LEP(1), LEPR(3), LHB(2), LHCGR(4), LTB4R(1), MC2R(1), MC3R(1), MC4R(1), MC5R(2), MCHR1(1), MTNR1A(1), NMBR(2), NMUR1(1), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR1(1), NPFFR2(1), NPY2R(2), NPY5R(4), NR3C1(2), OPRK1(1), OPRL1(1), OPRM1(6), OXTR(1), P2RX1(1), P2RX3(1), P2RY1(4), P2RY10(1), P2RY4(2), P2RY6(1), PARD3(4), PPYR1(1), PRL(2), PRLHR(2), PRSS1(1), PRSS3(1), PTGDR(1), PTGER2(1), PTGER3(2), PTGER4(1), PTGIR(2), PTH2R(2), RXFP1(1), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(1), TACR1(2), TACR2(2), TACR3(4), TRHR(4), TRPV1(1), TSHR(1), UTS2R(1), VIPR2(1) 64624790 316 136 315 121 119 75 67 19 36 0 0.891 1.000 1.000 425 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN1(3), ACTN2(2), APC(5), APC2(2), ARAF(2), ARHGEF1(1), ARHGEF12(3), ARHGEF4(4), ARHGEF6(3), ARHGEF7(3), ARPC1A(1), ARPC1B(1), ARPC2(1), BAIAP2(1), BCAR1(2), BDKRB2(3), CDC42(2), CFL1(1), CFL2(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CYFIP2(3), DIAPH2(1), DIAPH3(2), DOCK1(6), EGF(4), EGFR(4), EZR(2), F2(1), FGD3(2), FGF11(1), FGF13(1), FGF14(1), FGF20(1), FGF3(1), FGF6(2), FGFR2(3), FGFR3(1), FGFR4(1), FN1(7), GNA13(2), GNG12(1), GSN(1), IQGAP1(3), IQGAP2(3), IQGAP3(1), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(6), ITGAE(1), ITGAL(3), ITGAM(1), ITGAV(5), ITGAX(1), ITGB1(1), ITGB2(2), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), KRAS(4), LIMK2(2), MAP2K1(1), MAP2K2(2), MAPK1(1), MOS(1), MRAS(1), MSN(2), MYH10(3), MYH14(3), MYH9(2), MYLK2(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDGFA(1), PDGFB(1), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PPP1R12B(1), PTK2(6), PXN(1), RAC2(1), RAF1(1), ROCK1(3), ROCK2(3), SCIN(2), SOS1(4), SOS2(2), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(4), VAV1(3), VAV2(1), VAV3(4), VCL(3), WAS(1), WASF2(2), WASL(1) 83242327 298 135 296 84 153 45 51 12 37 0 0.0424 1.000 1.000 426 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(1), COL11A1(9), COL11A2(1), COL1A1(1), COL1A2(2), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), DES(1), DSC2(2), DSG2(1), DSG3(2), DSG4(1), FN1(7), GJA1(2), GJA5(1), GJA8(4), GJB1(1), GJB4(1), GJB5(1), GJC1(1), GJD2(1), IBSP(2), ITGB4(5), KRT1(4), KRT10(1), KRT14(2), KRT15(1), KRT16(1), KRT17(1), KRT18(1), KRT19(2), KRT2(1), KRT23(1), KRT25(1), KRT27(4), KRT28(1), KRT3(1), KRT31(2), KRT32(2), KRT33A(1), KRT33B(3), KRT34(3), KRT35(3), KRT36(2), KRT37(1), KRT38(3), KRT39(2), KRT4(1), KRT40(2), KRT5(3), KRT6A(1), KRT6B(1), KRT6C(2), KRT7(2), KRT71(1), KRT72(3), KRT73(2), KRT75(2), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(1), KRT81(3), KRT83(2), KRT84(1), KRT85(2), KRT86(3), KRT9(1), LAMA1(11), LAMA2(5), LAMA3(6), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(3), LMNA(2), LMNB1(1), LMNB2(2), NES(5), RELN(5), SPP1(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNC(4), TNN(5), TNR(3), TNXB(8), VIM(3), VTN(1), VWF(5) 74471764 303 132 303 105 113 63 73 10 43 1 0.755 1.000 1.000 427 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(1), ACTN1(3), ACTN2(2), AKT2(3), AKT3(1), AMOTL1(2), ASH1L(2), CDC42(2), CGN(1), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CSNK2A1(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTNNB1(52), CTTN(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC3(3), EXOC4(4), GNAI1(2), GNAI2(1), IGSF5(2), INADL(7), JAM2(1), JAM3(3), KRAS(4), MAGI1(1), MAGI2(5), MAGI3(1), MLLT4(3), MPDZ(4), MRAS(1), MYH1(5), MYH10(3), MYH11(4), MYH13(1), MYH14(3), MYH15(10), MYH2(3), MYH3(1), MYH4(6), MYH6(3), MYH7(8), MYH7B(2), MYH8(3), MYH9(2), NRAS(1), OCLN(1), PARD3(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R4(3), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PTEN(7), SPTAN1(4), SRC(1), TJAP1(1), TJP1(6), TJP2(2), YES1(2), ZAK(1) 57177199 238 128 211 68 99 38 54 16 30 1 0.302 1.000 1.000 428 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CD44(1), CD47(1), COL11A1(9), COL11A2(1), COL1A1(1), COL1A2(2), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), FN1(7), FNDC1(3), FNDC3A(1), GP6(2), HMMR(3), HSPG2(6), IBSP(2), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(5), ITGB1(1), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), LAMA1(11), LAMA2(5), LAMA3(6), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(3), RELN(5), SPP1(1), SV2A(2), SV2C(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNC(4), TNN(5), TNR(3), TNXB(8), VTN(1), VWF(5) 67627948 252 123 251 91 99 47 58 13 34 1 0.842 1.000 1.000 429 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(2), ABLIM2(2), ARHGEF12(3), CDC42(2), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(1), DPYSL5(2), EFNA3(1), EFNA4(1), EFNA5(2), EFNB2(2), EPHA1(4), EPHA2(2), EPHA3(6), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(3), EPHA8(3), EPHB1(3), EPHB2(4), EPHB3(4), FES(1), FYN(1), GNAI1(2), GNAI2(1), GSK3B(2), ITGB1(1), KRAS(4), L1CAM(3), LIMK2(2), LRRC4C(4), MAPK1(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NGEF(2), NRAS(1), NRP1(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNB3(6), PLXNC1(2), PPP3CA(4), PTK2(6), RAC2(1), RASA1(4), RGS3(1), ROBO1(8), ROBO2(9), ROBO3(1), ROCK1(3), ROCK2(3), SEMA3A(6), SEMA3C(3), SEMA3D(6), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4D(2), SEMA4F(2), SEMA5B(2), SEMA6A(5), SEMA6B(1), SEMA6C(3), SEMA6D(9), SEMA7A(4), SLIT1(2), SLIT2(8), SLIT3(1), SRGAP1(1), SRGAP2(1), SRGAP3(4), UNC5D(4) 58589345 248 121 248 83 111 53 44 14 24 2 0.550 1.000 1.000 430 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(3), ATP1B3(1), ATP2A3(1), ATP2B1(1), ATP2B2(4), CACNA1A(6), CACNA1B(6), CACNA1C(4), CACNA1D(3), CACNA1E(18), CACNA1S(2), CACNB1(1), CALR(3), CAMK2A(3), CAMK2B(1), CASQ1(2), CASQ2(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), GJA1(2), GJA5(1), GJB1(1), GJB4(1), GJB5(1), GNAI2(1), GNB1(1), GNB2(1), GNB4(1), GNB5(3), GNG12(1), GNG5(1), GRK6(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MIB1(2), PLCB3(2), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(2), RGS11(1), RGS14(1), RGS16(2), RGS18(2), RGS20(1), RGS3(1), RGS4(1), RGS7(4), RGS9(2), RYR1(9), RYR2(24), RYR3(13), SLC8A1(4), USP5(3), YWHAH(1) 56813080 229 119 229 81 86 57 49 10 27 0 0.803 1.000 1.000 431 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 252 ACVR1(1), ACVR1B(1), ACVR2A(6), ACVR2B(1), AMH(1), AMHR2(1), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(3), CCL11(1), CCL13(1), CCL14(1), CCL15(1), CCL18(1), CCL25(1), CCL3(1), CCL8(1), CCR1(2), CCR2(3), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CCR9(1), CD27(1), CD70(1), CLCF1(1), CRLF2(1), CSF2RB(1), CXCL1(1), CXCL14(1), CXCL16(1), CXCR3(1), CXCR4(1), CXCR6(1), EDA(1), EDAR(1), EGF(4), EGFR(4), FASLG(1), FLT1(4), FLT3(2), FLT3LG(2), FLT4(4), GDF5(2), GH1(1), GH2(4), GHR(1), HGF(5), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), IFNW1(2), IL10RA(3), IL11RA(1), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL18(2), IL18R1(1), IL18RAP(4), IL1B(1), IL1R1(3), IL20RA(2), IL21(1), IL21R(5), IL23A(1), IL23R(2), IL2RB(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(7), IL7(1), IL7R(1), IL9R(2), INHBA(2), INHBE(1), KDR(8), KIT(5), KITLG(2), LEP(1), LEPR(3), LIF(1), LIFR(2), LTA(1), NGFR(1), PDGFB(1), PDGFC(1), PDGFRA(4), PDGFRB(1), PF4V1(1), PLEKHO2(1), PPBP(1), PRL(2), RELT(1), TGFB2(2), TGFB3(2), TGFBR1(1), TNF(2), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(5), TNFRSF18(1), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(3), TNFRSF6B(1), TNFRSF8(1), TNFSF13B(1), TPO(9), TSLP(1), VEGFC(3) 52495633 250 119 250 58 93 47 56 15 38 1 0.0137 1.000 1.000 432 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(3), ACTN2(2), ARHGAP5(2), BCAR1(2), CD99(1), CDC42(2), CDH5(2), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTNNB1(52), CTNND1(2), CXCR4(1), CYBA(1), EZR(2), GNAI1(2), GNAI2(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), JAM2(1), JAM3(3), MAPK14(2), MLLT4(3), MMP2(1), MMP9(1), MSN(2), NCF2(1), NCF4(1), NOX1(3), NOX3(4), OCLN(1), PECAM1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PRKCA(1), PRKCG(1), PTK2(6), PTK2B(4), PTPN11(1), PXN(1), RAC2(1), RAP1A(1), RAPGEF3(2), RHOH(1), ROCK1(3), ROCK2(3), TXK(2), VASP(1), VAV1(3), VAV2(1), VAV3(4), VCAM1(1), VCL(3) 37040725 190 117 162 35 93 28 39 12 17 1 0.000511 1.000 1.000 433 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(3), ACACB(6), AKT2(3), AKT3(1), ARAF(2), CBL(1), CBLB(2), EXOC7(1), FASN(10), FLOT1(3), FLOT2(1), G6PC(1), GSK3B(2), GYS1(2), GYS2(1), IKBKB(3), INPP5D(1), INSR(6), IRS2(1), IRS4(5), KRAS(4), LIPE(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK10(3), MAPK9(1), MKNK1(1), MKNK2(1), NRAS(1), PCK1(5), PDE3A(5), PFKL(1), PFKP(2), PHKA1(2), PHKA2(2), PHKB(5), PHKG2(3), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PPARGC1A(3), PPP1CA(2), PPP1CC(1), PPP1R3A(5), PPP1R3B(1), PRKAA1(3), PRKAB2(1), PRKACA(1), PRKACB(1), PRKAG2(1), PRKAR2B(1), PRKCZ(1), PRKX(2), PTPRF(1), PYGB(1), PYGL(1), PYGM(5), RAF1(1), RAPGEF1(4), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC4(3), SLC2A4(1), SORBS1(2), SOS1(4), SOS2(2), SREBF1(4), TRIP10(1), TSC1(7), TSC2(9) 47787489 192 114 191 42 104 25 22 7 34 0 0.00243 1.000 1.000 434 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ARRB1(1), ARRB2(1), ATF5(1), ATP2A3(1), CALCA(1), CAMK2A(3), CAMK2B(1), CORIN(3), CREB3(1), CRHR1(3), DGKZ(1), ETS2(1), FOS(2), GJA1(2), GNB1(1), GNB2(1), GNB4(1), GNB5(3), GNG12(1), GNG5(1), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(1), IL6(2), ITPR1(6), ITPR2(3), ITPR3(8), JUN(1), MIB1(2), MYLK2(1), NFKB1(2), NOS1(9), NOS3(2), OXTR(1), PDE4B(2), PDE4D(3), PLCB3(2), PLCD1(1), PLCG1(3), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(2), RGS11(1), RGS14(1), RGS16(2), RGS18(2), RGS20(1), RGS3(1), RGS4(1), RGS7(4), RGS9(2), RYR1(9), RYR2(24), RYR3(13), SLC8A1(4), SP1(2), TNXB(8), USP5(3), YWHAH(1) 52146524 209 114 209 64 89 44 42 10 24 0 0.330 1.000 1.000 435 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), CAMK2A(3), CAMK2B(1), CREB3(1), CREB3L1(2), CREB3L3(2), CREBBP(6), CTNNB1(52), DCT(1), DVL1(1), DVL2(4), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(1), FZD5(1), FZD9(2), GNAI1(2), GNAI2(1), GNAS(7), GSK3B(2), KIT(5), KITLG(2), KRAS(4), LEF1(2), MAP2K1(1), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), POMC(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), RAF1(1), TCF7(3), TCF7L1(3), TCF7L2(2), TYR(4), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1) 32028194 195 113 166 44 86 33 39 13 23 1 0.0140 1.000 1.000 436 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTG1(1), ACTN1(3), ACTN2(2), ACVR1B(1), ACVR1C(1), BAIAP2(1), CDC42(2), CDH1(2), CREBBP(6), CSNK2A1(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTNNB1(52), CTNND1(2), EGFR(4), EP300(3), FARP2(2), FER(1), FYN(1), IGF1R(6), INSR(6), IQGAP1(3), LEF1(2), LMO7(4), MAP3K7(1), MAPK1(1), MLLT4(3), NLK(1), PARD3(4), PTPN6(1), PTPRB(6), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(1), PVRL2(2), RAC2(1), SMAD3(2), SNAI1(2), SORBS1(2), SRC(1), SSX2IP(1), TCF7(3), TCF7L1(3), TCF7L2(2), TGFBR1(1), TJP1(6), VCL(3), WAS(1), WASF2(2), WASF3(2), WASL(1), YES1(2) 35593914 178 111 151 44 83 21 40 11 22 1 0.0422 1.000 1.000 437 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 AKT2(3), AKT3(1), CBL(1), CBLB(2), CCND2(1), CISH(2), CLCF1(1), CREBBP(6), CRLF2(1), CSF2RB(1), EP300(3), GH1(1), GH2(4), GHR(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), IFNW1(2), IL10RA(3), IL11RA(1), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL20RA(2), IL21(1), IL21R(5), IL23A(1), IL23R(2), IL2RB(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(7), IL7(1), IL7R(1), IL9R(2), IRF9(1), JAK1(2), JAK2(4), JAK3(3), LEP(1), LEPR(3), LIF(1), LIFR(2), MYC(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PRL(2), PTPN11(1), PTPN6(1), SOCS5(1), SOS1(4), SOS2(2), SPRY2(1), SPRY3(1), STAM(1), STAT1(2), STAT2(1), STAT3(3), STAT4(3), STAT5A(2), STAT5B(1), STAT6(1), TPO(9), TSLP(1), TYK2(2) 43048348 178 106 177 42 76 32 32 11 27 0 0.0561 1.000 1.000 438 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(5), CD22(3), CD276(1), CD4(1), CD6(2), CD80(1), CD86(1), CD8B(1), CD99(1), CDH1(2), CDH15(4), CDH2(1), CDH3(1), CDH4(2), CDH5(2), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CNTN1(2), CNTN2(3), CNTNAP2(5), CTLA4(1), GLG1(3), HLA-B(1), HLA-DMA(1), HLA-DMB(2), HLA-DPB1(1), HLA-E(3), HLA-G(1), ICAM1(1), ICAM3(1), ITGA4(2), ITGA8(3), ITGA9(4), ITGAL(3), ITGAM(1), ITGAV(5), ITGB1(1), ITGB2(2), ITGB7(1), ITGB8(2), JAM2(1), JAM3(3), L1CAM(3), MAG(2), NCAM1(4), NCAM2(2), NEGR1(1), NEO1(4), NFASC(3), NLGN1(8), NLGN3(2), NRCAM(2), NRXN1(4), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PECAM1(1), PTPRC(4), PTPRF(1), PTPRM(8), PVR(1), PVRL1(1), PVRL2(2), SELE(1), SELL(1), SELP(1), SIGLEC1(3), SPN(1), VCAM1(1), VCAN(12) 43601172 166 104 166 62 81 34 27 7 17 0 0.760 1.000 1.000 439 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BID(1), CD244(2), FASLG(1), FCGR3B(3), FYN(1), GZMB(1), HLA-B(1), HLA-E(3), HLA-G(1), ICAM1(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR2DL3(4), KRAS(4), LCK(3), LCP2(3), MAP2K1(1), MAP2K2(2), MAPK1(1), MICA(2), NCR1(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NRAS(1), PAK1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PPP3CA(4), PRF1(3), PRKCA(1), PRKCG(1), PTK2B(4), PTPN11(1), PTPN6(1), RAC2(1), RAF1(1), SH3BP2(2), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SYK(1), TNF(2), TNFRSF10D(1), VAV1(3), VAV2(1), VAV3(4), ZAP70(1) 33482480 150 102 149 35 75 22 27 12 14 0 0.0262 1.000 1.000 440 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), DRD2(1), EGF(4), EGFR(4), GJA1(2), GJD2(1), GNAI1(2), GNAI2(1), GNAS(7), GRM1(3), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), HTR2C(4), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), MAP2K1(1), MAP2K2(2), MAP3K2(1), MAPK1(1), MAPK7(4), NPR1(2), NPR2(1), NRAS(1), PDGFA(1), PDGFB(1), PDGFC(1), PDGFD(2), PDGFRA(4), PDGFRB(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKG1(4), PRKX(2), RAF1(1), SOS1(4), SOS2(2), SRC(1), TJP1(6), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(2) 39436688 172 99 170 51 81 33 34 4 20 0 0.236 1.000 1.000 441 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 AKT2(3), AKT3(1), ARAF(2), CAMK2A(3), CAMK2B(1), CBL(1), CBLB(2), CDKN1A(5), EGF(4), EGFR(4), ERBB3(6), ERBB4(4), GAB1(4), GSK3B(2), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK9(1), MYC(1), NRAS(1), NRG1(2), NRG2(2), NRG3(2), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PRKCA(1), PRKCG(1), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SRC(1), STAT5A(2), STAT5B(1), TGFA(1) 30597800 137 96 136 28 64 24 24 4 21 0 0.0150 1.000 1.000 442 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(4), CAPN3(2), CAPN6(1), CAPN9(2), CAPNS1(1), CAV1(1), CAV2(1), CDC42(2), DOCK1(6), FYN(1), GIT2(1), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(6), ITGAE(1), ITGAL(3), ITGAM(1), ITGAV(5), ITGAX(1), ITGB1(1), ITGB2(2), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), MAP2K1(1), MAP2K2(2), MAPK10(3), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(6), PXN(1), RAC2(1), RAPGEF1(4), RHO(1), ROCK1(3), ROCK2(3), SDCCAG8(3), SEPP1(1), SHC1(2), SORBS1(2), SOS1(4), SRC(1), TLN1(3), TNS1(3), VASP(1), VAV2(1), VAV3(4), VCL(3), ZYX(1) 40636285 158 94 157 49 76 25 26 8 23 0 0.378 1.000 1.000 443 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), CACNA1A(6), CRHR1(3), GNA13(2), GNAI1(2), GNAI2(1), GNAS(7), GRIA1(5), GRIA2(7), GRIA3(5), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), IGF1R(6), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), LYN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), NOS1(9), NOS3(2), NPR1(2), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2B(1), PPP2R2C(2), PRKCA(1), PRKCG(1), PRKG1(4), RAF1(1), RYR1(9) 33124467 159 93 157 49 77 36 30 2 14 0 0.235 1.000 1.000 444 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), CACNA1C(4), CACNA1D(3), CACNA1F(1), CACNA1S(2), CAMK2A(3), CAMK2B(1), CDC42(2), EGFR(4), GNAS(7), GNRH2(1), ITPR1(6), ITPR2(3), ITPR3(8), JUN(1), KRAS(4), LHB(2), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K2(1), MAP3K4(4), MAPK1(1), MAPK10(3), MAPK14(2), MAPK7(4), MAPK9(1), MMP14(1), MMP2(1), NRAS(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLD1(2), PLD2(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKX(2), PTK2B(4), RAF1(1), SOS1(4), SOS2(2), SRC(1) 38707887 158 92 156 42 75 32 25 4 22 0 0.105 1.000 1.000 445 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(2), DES(1), DMD(14), MYBPC1(2), MYBPC2(2), MYBPC3(3), MYH3(1), MYH6(3), MYH7(8), MYH8(3), MYOM1(2), NEB(11), TCAP(1), TNNC2(1), TNNI2(2), TNNT2(1), TNNT3(1), TPM1(2), TPM2(3), TPM4(1), TTN(82), VIM(3) 41737524 149 92 148 53 64 21 43 9 12 0 0.839 1.000 1.000 446 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ADSL(1), ADSS(2), ADSSL1(1), AK2(1), AK5(1), AK7(2), ALLC(1), AMPD1(3), AMPD2(1), AMPD3(1), ENPP3(1), ENTPD1(3), ENTPD6(1), GART(1), GMPS(2), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), GUK1(1), IMPDH1(2), IMPDH2(2), NME1(1), NME6(1), NPR1(2), NPR2(1), NT5C1B(1), NT5C2(1), PAICS(1), PDE10A(4), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(3), PDE7A(1), PDE7B(1), PDE8A(4), PDE9A(1), PFAS(1), POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1), PPAT(1), PRIM2(2), PRPS1L1(1), PRPS2(1), RFC5(2), RRM1(1), XDH(4) 48625911 140 89 140 52 59 29 27 6 19 0 0.764 1.000 1.000 447 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(3), ACTR3(1), AKT2(3), AKT3(1), ARHGEF6(3), ARHGEF7(3), BCAR1(2), CAV1(1), CDC42(2), CDKN2A(1), DOCK1(6), EPHB2(4), FYN(1), GRB7(2), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGB3BP(1), MAP2K4(3), MAP3K11(2), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK2(1), P4HB(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CB(1), PLCG1(3), PLCG2(5), PTEN(7), PTK2(6), RAF1(1), RHO(1), ROCK1(3), ROCK2(3), SHC1(2), SOS1(4), SOS2(2), SRC(1), TLN1(3), TLN2(2), VASP(1), WAS(1), ZYX(1) 36401368 146 89 145 32 68 24 26 7 21 0 0.0304 1.000 1.000 448 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(1), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), AVPR1B(1), BDKRB2(3), C3AR1(1), CCKBR(3), CCR1(2), CCR2(3), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CCR9(1), CHML(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CMKLR1(1), CNR1(2), CNR2(1), CXCR3(1), CXCR4(1), DRD2(1), DRD3(1), DRD5(2), EDNRA(3), EDNRB(1), F2RL3(1), FPR1(1), GALR1(1), GALT(1), GHSR(2), GNB2L1(1), GPR17(2), GPR173(2), GPR174(2), GPR3(1), GPR35(1), GPR37(1), GPR50(2), GPR63(4), GPR83(1), GPR85(2), HCRTR1(1), HRH2(1), HRH3(2), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), LHCGR(4), LTB4R(1), MC3R(1), MC4R(1), MC5R(2), MTNR1A(1), NMBR(2), NMUR1(1), NMUR2(1), NPY2R(2), NPY5R(4), OPRK1(1), OPRL1(1), OPRM1(6), OR10A5(1), OR11A1(2), OR12D3(3), OR1C1(1), OR5V1(2), OR7A5(1), OR8B8(2), OXTR(1), P2RY1(4), P2RY10(1), P2RY12(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2), RHO(1), SSTR2(1), SSTR3(2), SSTR4(2), SUCNR1(1), TRHR(4) 34832889 170 88 170 60 67 41 43 9 10 0 0.467 1.000 1.000 449 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(3), ADCY8(5), ARAF(2), CACNA1C(4), CAMK2A(3), CAMK2B(1), CREBBP(6), EP300(3), GRIA1(5), GRIA2(7), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), GRM1(3), GRM5(3), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), MAP2K1(1), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PPP3CA(4), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5) 30250454 131 88 131 49 70 18 24 4 15 0 0.624 1.000 1.000 450 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDIPT(1), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), IMPA1(1), IMPA2(2), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), INPP5D(1), INPPL1(2), ITPK1(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), OCRL(2), PI4KA(2), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(7), SYNJ1(3), SYNJ2(1) 37536110 130 86 129 49 69 22 15 4 20 0 0.715 1.000 1.000 451 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(2), DOT1L(4), EED(2), EHMT1(2), EHMT2(2), EZH1(1), FBXO11(1), HSF4(1), JMJD6(1), KDM6A(1), MEN1(1), MLL(6), MLL2(11), MLL3(14), MLL4(9), MLL5(5), NSD1(6), PPP1CA(2), PPP1CC(1), PRDM2(7), PRDM7(1), PRDM9(1), PRMT1(2), PRMT6(2), PRMT7(1), PRMT8(1), RBBP5(2), SATB1(4), SETD1A(5), SETD1B(2), SETD2(8), SETD8(2), SETDB1(1), SETDB2(2), SUV39H1(1), SUV39H2(1), SUV420H1(3), WHSC1(2), WHSC1L1(2) 37288254 122 85 122 36 51 19 14 13 25 0 0.336 1.000 1.000 452 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADSL(1), ADSS(2), AK2(1), AK5(1), ALLC(1), AMPD1(3), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(3), ATP5C1(1), ATP5G3(1), ENPP3(1), ENTPD1(3), GART(1), GMPS(2), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), GUK1(1), IMPDH1(2), IMPDH2(2), NME1(1), NPR1(2), NPR2(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(3), PDE6B(3), PDE7B(1), PDE8A(4), PDE9A(1), PFAS(1), POLD1(2), POLE(3), POLG(4), POLQ(7), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), PPAT(1), PRPS1L1(1), PRPS2(1), RRM1(1) 38049270 123 85 123 41 59 28 21 3 12 0 0.435 1.000 1.000 453 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT2(3), AKT3(1), CASP8(1), CCL3(1), CD80(1), CD86(1), CHUK(2), FADD(2), FOS(2), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IKBKB(3), IL12A(5), IL12B(1), IL1B(1), IL6(2), IRAK1(2), IRAK4(2), IRF3(1), JUN(1), LBP(2), LY96(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K7(1), MAPK1(1), MAPK10(3), MAPK14(2), MAPK9(1), MYD88(1), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), RELA(1), RIPK1(2), SPP1(1), STAT1(2), TBK1(1), TICAM1(2), TLR2(1), TLR3(1), TLR4(2), TLR5(1), TLR7(2), TLR8(5), TLR9(2), TNF(2), TRAF6(1) 26462120 116 82 115 34 59 15 21 7 14 0 0.317 1.000 1.000 454 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT2(3), AKT3(1), BCL10(1), CARD11(8), CBL(1), CBLB(2), CD4(1), CD8B(1), CDC42(2), CHUK(2), CTLA4(1), FOS(2), FYN(1), GRAP2(2), IFNG(2), IKBKB(3), IL4(1), JUN(1), KRAS(4), LCK(3), LCP2(3), MALT1(3), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDCD1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PPP3CA(4), PRKCQ(2), PTPN6(1), PTPRC(4), RASGRP1(3), SOS1(4), SOS2(2), TNF(2), VAV1(3), VAV2(1), VAV3(4), ZAP70(1) 29987871 135 82 134 32 70 19 25 6 15 0 0.0556 1.000 1.000 455 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(2), ABCA12(7), ABCA13(24), ABCA2(2), ABCA3(3), ABCA4(10), ABCA5(1), ABCA6(3), ABCA7(5), ABCA8(1), ABCA9(2), ABCB1(5), ABCB10(2), ABCB11(2), ABCB4(2), ABCB5(9), ABCB6(1), ABCB7(1), ABCC10(3), ABCC11(2), ABCC2(2), ABCC3(5), ABCC4(4), ABCC5(2), ABCC6(1), ABCC8(6), ABCC9(4), ABCD1(1), ABCD2(3), ABCG1(1), ABCG2(2), ABCG5(1), CFTR(5), TAP1(2) 35491477 132 81 132 37 50 28 27 6 21 0 0.212 1.000 1.000 456 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1B(1), ACVR1C(1), ACVR2A(6), ACVR2B(1), ACVRL1(2), AMH(1), AMHR2(1), BMP2(1), BMP5(3), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(3), CHRD(1), CREBBP(6), CUL1(1), DCN(2), EP300(3), GDF5(2), IFNG(2), INHBA(2), INHBE(1), LTBP1(4), MAPK1(1), MYC(1), NOG(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2B(1), PPP2R2C(2), RBL1(3), RBL2(5), ROCK1(3), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD3(2), SMAD5(2), SMAD7(1), SMAD9(1), SMURF1(2), SP1(2), TFDP1(1), TGFB2(2), TGFB3(2), TGFBR1(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNF(2), ZFYVE16(3), ZFYVE9(3) 29024049 108 81 108 29 53 11 19 5 18 2 0.147 1.000 1.000 457 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), ACVR1B(1), ACVRL1(2), BMPR1A(1), BMPR2(3), BUB1(1), CDIPT(1), CDKL2(1), CLK2(1), CLK4(3), COL4A3BP(1), CSNK2A1(1), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(1), MOS(1), OCRL(2), PAK4(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CG(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(2), PRKG1(4), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KB1(1), TGFBR1(1) 33950049 116 81 115 51 60 20 19 2 15 0 0.929 1.000 1.000 458 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY2(6), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), AKAP1(3), AKAP11(3), AKAP12(2), AKAP3(3), AKAP4(5), AKAP6(2), AKAP8(3), AKAP9(4), ARHGEF1(1), GNA13(2), GNA15(1), GNAI2(1), GNAL(2), GNB1(1), GNB2(1), GNB5(3), GNG12(1), GNG5(1), ITPR1(6), KCNJ3(1), KRAS(4), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(5), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(3), PDE7A(1), PDE7B(1), PDE8A(4), PLCB3(2), PPP3CA(4), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(2), USP5(3) 34373821 121 80 121 36 58 28 15 3 17 0 0.327 1.000 1.000 459 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(3), AKT3(1), CDC42(2), KDR(8), KRAS(4), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK14(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NOS3(2), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCG1(3), PLCG2(5), PPP3CA(4), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(6), PXN(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK1(2), SPHK2(1), SRC(1) 21387138 106 80 105 22 58 16 15 2 15 0 0.0140 1.000 1.000 460 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT2(3), AKT3(1), BCL10(1), BLNK(2), BTK(1), CARD11(8), CD19(1), CD22(3), CD81(1), CHUK(2), CR2(5), FOS(2), GSK3B(2), IKBKB(3), INPP5D(1), JUN(1), KRAS(4), LYN(1), MALT1(3), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG2(5), PPP3CA(4), PTPN6(1), RAC2(1), SYK(1), VAV1(3), VAV2(1), VAV3(4) 22047851 103 75 102 23 57 15 15 4 12 0 0.0423 1.000 1.000 461 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(6), ACSL1(1), ACSL5(1), ACSL6(1), ADIPOR1(1), ADIPOR2(1), AKT2(3), AKT3(1), CD36(1), CHUK(2), CPT1A(3), CPT1B(3), CPT1C(2), G6PC(1), IKBKB(3), IRS2(1), IRS4(5), JAK1(2), JAK2(4), JAK3(3), LEP(1), LEPR(3), MAPK10(3), MAPK9(1), NFKB1(2), NFKBIA(2), PCK1(5), POMC(2), PPARA(2), PPARGC1A(3), PRKAA1(3), PRKAB2(1), PRKAG2(1), PRKCQ(2), PTPN11(1), RELA(1), RXRA(5), RXRB(2), RXRG(1), SLC2A4(1), STAT3(3), TNF(2), TNFRSF1A(1), TYK2(2) 24621081 95 75 95 36 45 17 20 6 7 0 0.781 1.000 1.000 462 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT2(3), AKT3(1), BTK(1), FYN(1), IL4(1), INPP5D(1), KRAS(4), LCP2(3), LYN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK9(1), MS4A2(3), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCG1(3), PLCG2(5), PRKCA(1), RAC2(1), RAF1(1), SOS1(4), SOS2(2), SYK(1), TNF(2), VAV1(3), VAV2(1), VAV3(4) 21024581 96 74 95 20 49 17 15 4 11 0 0.0380 1.000 1.000 463 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(3), BAG4(2), BCL2(1), BID(1), BIRC2(1), BIRC3(1), CASP6(1), CASP7(1), CASP8(1), CFLAR(1), CHUK(2), CRADD(1), DFFB(1), FADD(2), GSN(1), LMNA(2), LMNB1(1), LMNB2(2), MAP3K1(2), MAP3K5(2), MDM2(1), NFKB1(2), NFKBIA(2), NUMA1(2), PRKDC(12), PSEN1(1), PTK2(6), RASA1(4), RB1(16), RELA(1), RIPK1(2), SPTAN1(4), TNF(2), TNFRSF1A(1), TRAF1(1) 20729147 87 73 86 19 30 12 11 7 26 1 0.153 1.000 1.000 464 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(3), AMY2A(2), AMY2B(1), ASCC3(6), ATP13A2(1), DDX18(1), DDX4(1), DDX41(1), DDX47(1), DDX50(4), DDX56(1), ENPP3(1), EP400(2), ERCC2(2), ERCC3(3), G6PC(1), GAA(1), GPI(2), GUSB(3), GYS1(2), GYS2(1), HK1(1), HK2(4), HK3(3), LYZL1(1), MGAM(5), MOV10L1(1), PGM3(2), PYGB(1), PYGL(1), PYGM(5), RAD54B(3), SETX(3), SI(4), SKIV2L2(1), SMARCA2(3), SMARCA5(1), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2A1(2), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2) 39246536 99 72 99 37 50 18 8 7 16 0 0.779 1.000 1.000 465 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG1(1), ALG10B(1), ALG13(2), ALG2(1), ALG3(1), ALG6(1), ALG8(1), ALG9(3), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), CHPF(4), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST2(3), CHST3(3), CHST7(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT8(1), GALNT1(2), GALNT11(1), GALNT12(2), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(3), GALNT8(2), GALNTL5(2), GANAB(1), GCNT3(1), HS2ST1(2), MAN1A1(1), MAN1A2(2), MAN1C1(1), MAN2A1(3), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2), MGAT5B(2), NDST1(1), NDST2(2), NDST3(1), NDST4(6), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(3), UST(1), WBSCR17(5) 32301272 100 72 99 34 49 23 13 5 10 0 0.379 1.000 1.000 466 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 CHUK(2), FOS(2), IKBKB(3), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K11(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAP4K5(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK4(1), MAPK6(2), MAPK7(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(2), NFKBIA(2), PAK1(1), RAF1(1), RELA(1), RIPK1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KA5(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB2(2), TGFB3(2), TGFBR1(1) 29104479 96 72 96 31 47 11 23 2 13 0 0.457 1.000 1.000 467 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(2), BDKRB2(3), C1QA(2), C1QC(1), C1R(1), C1S(1), C2(1), C3(8), C3AR1(1), C4A(1), C4BPA(1), C5(3), C6(1), C7(1), C8B(1), C9(2), CD46(2), CD55(1), CFB(1), CFH(4), CFI(2), CPB2(2), CR1(6), CR2(5), F10(3), F13A1(1), F13B(1), F2(1), F3(1), F5(4), F8(2), FGA(6), KLKB1(2), MASP2(1), PLAU(1), PROC(1), PROS1(2), SERPINC1(2), SERPIND1(1), SERPINE1(1), THBD(1), VWF(5) 31229856 89 67 88 32 39 11 13 9 17 0 0.693 1.000 1.000 468 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(2), CD19(1), CD1B(1), CD1C(1), CD1D(1), CD1E(3), CD22(3), CD36(1), CD37(1), CD38(2), CD4(1), CD44(1), CD5(1), CD55(1), CD8B(1), CD9(1), CR1(6), CR2(5), DNTT(1), FCGR1A(2), FLT3(2), FLT3LG(2), GYPA(1), IL11RA(1), IL1B(1), IL1R1(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7(1), IL7R(1), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGAM(1), KIT(5), KITLG(2), MME(5), TFRC(1), TNF(2), TPO(9) 24864788 91 67 91 30 34 15 20 6 16 0 0.629 1.000 1.000 469 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(1), CLK2(1), CLK3(1), CLK4(3), COL2A1(4), CPSF1(3), CPSF3(1), CPSF4(1), CSTF2(1), DDIT3(1), DDX20(1), DHX15(1), DHX16(4), DHX9(6), DICER1(4), DNAJC8(1), FUS(2), GIPC1(1), LOC440563(1), NCBP1(1), NONO(1), NUDT21(1), NXF1(3), PAPOLA(1), POLR2A(5), PRPF4(1), PRPF4B(2), PRPF8(5), PSKH1(1), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A1(2), SF3A3(1), SF3B1(3), SF3B2(1), SNRPA1(1), SNRPB(1), SNRPN(1), SPOP(4), SRPK1(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(1) 31363250 86 66 86 28 39 16 18 4 8 1 0.599 1.000 1.000 470 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BCL2(1), CABIN1(5), CAMK2B(1), CD69(2), CDKN1A(5), CNR1(2), CREBBP(6), CSNK2A1(1), CTLA4(1), EP300(3), FOS(2), GSK3B(2), IFNB1(1), IFNG(2), IL1B(1), IL4(1), IL6(2), JUNB(1), KPNA5(1), MAPK14(2), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NUP214(3), PAK1(1), PIN1(1), PTPRC(4), RELA(1), SP1(2), SP3(3), TNF(2), TRPV6(1), VAV1(3), VAV2(1), VAV3(4), XPO5(1) 26748250 86 65 86 23 35 10 20 8 13 0 0.297 1.000 1.000 471 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), IMPA2(2), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), INPPL1(2), ITPK1(1), ITPKB(1), MINPP1(1), OCRL(2), PI4KA(2), PI4KB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), PTEN(7), SYNJ1(3), SYNJ2(1) 22057731 80 63 79 30 42 15 8 2 13 0 0.694 1.000 1.000 472 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), CDC42(2), CHUK(2), CXCL1(1), EGFR(4), IGSF5(2), IKBKB(3), JAM2(1), JAM3(3), JUN(1), LYN(1), MAP2K4(3), MAPK10(3), MAPK14(2), MAPK9(1), NFKB1(2), NFKBIA(2), PAK1(1), PLCG1(3), PLCG2(5), PTPN11(1), PTPRZ1(5), RELA(1), SRC(1), TJP1(6) 21060388 75 60 75 17 30 13 16 3 13 0 0.258 1.000 1.000 473 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(4), AVPR1B(1), BDKRB2(3), C3AR1(1), CCKBR(3), CCR1(2), CCR2(3), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(3), EDNRB(1), FPR1(1), GALR1(1), GALT(1), GHSR(2), GNB2L1(1), LHCGR(4), MC2R(1), MC3R(1), MC4R(1), MC5R(2), NMBR(2), NPY2R(2), NPY5R(4), OPRK1(1), OPRL1(1), OPRM1(6), OXTR(1), PPYR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR1(2), TACR2(2), TACR3(4), TRHR(4), TSHR(1) 14952380 85 60 85 29 35 19 19 5 7 0 0.452 1.000 1.000 474 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR3(1), AKT2(3), AKT3(1), ARHGEF11(1), BTK(1), CDC42(2), CFL1(1), CFL2(1), INPPL1(2), ITPR1(6), ITPR2(3), ITPR3(8), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CD(4), PIK3CG(2), PIK3R1(2), PPP1R13B(5), PTEN(7), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(3), SAG(1), WASL(1) 20909973 82 58 81 21 40 12 10 4 16 0 0.187 1.000 1.000 475 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(2), ADCY8(5), CACNA1A(6), CACNA1B(6), GNAS(7), GNAT3(1), GNB1(1), GRM4(2), ITPR3(8), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(1), PRKX(2), SCNN1A(2), SCNN1G(2), TAS1R1(2), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R10(1), TAS2R16(2), TAS2R3(1), TAS2R39(2), TAS2R41(1), TAS2R46(2), TAS2R7(1), TAS2R9(1), TRPM5(2) 17135617 71 57 69 25 33 14 11 2 11 0 0.611 1.000 1.000 476 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(4), CREBBP(6), CTBP2(2), DLL3(1), DTX3(4), DTX3L(2), DVL1(1), DVL2(4), EP300(3), HDAC2(1), HES1(2), JAG2(3), LFNG(2), MAML2(1), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(1), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMB(1), PSEN1(1), RBPJ(1), RBPJL(1), SNW1(2) 20995210 69 54 69 22 34 11 15 5 4 0 0.444 1.000 1.000 477 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(3), AKT3(1), ASAH1(1), DRD2(1), EGFR(4), EPHB2(4), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), PIK3CB(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(4), SOS2(2), SRC(1), STAT3(3) 17312297 65 54 65 23 32 10 15 3 5 0 0.729 1.000 1.000 478 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), CDIPT(1), CHAT(4), CHKA(1), CHPT1(1), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), ESCO1(2), ESCO2(2), GNPAT(1), GPAM(3), GPD1L(1), PCYT1A(1), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLD1(2), PLD2(2), PNPLA3(1), PPAP2A(3), PPAP2C(3), PTDSS1(1), SH3GLB1(1) 19680834 64 53 64 21 35 14 7 1 7 0 0.316 1.000 1.000 479 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 CPEB1(1), EGFR(4), ERBB4(4), ETS1(1), ETS2(1), FMN2(4), KRAS(4), MAP2K1(1), MAPK1(1), NOTCH1(1), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(2), PIWIL3(1), PIWIL4(7), RAF1(1), SOS1(4), SOS2(2), SPIRE1(3), SPIRE2(1) 15524113 59 53 59 17 28 13 12 1 5 0 0.389 1.000 1.000 480 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), ALG6(1), CCKBR(3), CCR2(3), CCR3(1), CELSR1(8), CELSR2(6), CELSR3(3), CHRM2(4), CHRM3(3), CXCR3(1), EDNRA(3), EMR2(1), EMR3(4), GPR116(3), GPR132(3), GPR133(2), GPR135(2), GPR17(2), GPR56(1), GPR61(1), GPR84(4), GRM1(3), HRH4(1), LGR6(2), LPHN2(2), LPHN3(4), OR8G2(1), SSTR2(1), TAAR5(1), TSHR(1) 19440019 77 52 77 36 38 15 14 1 9 0 0.927 1.000 1.000 481 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(2), ADH1B(2), ADH5(1), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(4), DCT(1), DDC(1), ECH1(1), ESCO1(2), ESCO2(2), GSTZ1(1), HEMK1(2), HGD(1), HPD(2), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT6(2), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(2), TPO(9), TYR(4) 17361228 62 51 62 14 30 11 13 1 7 0 0.108 1.000 1.000 482 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(3), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(1), EPHB2(4), ITPKB(1), LYN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIL1(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(4), SOS2(2), SYK(1), VAV1(3) 15534272 64 51 63 16 38 9 8 2 7 0 0.159 1.000 1.000 483 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(2), ABP1(2), ACAT1(1), ACAT2(4), AFMID(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), AOX1(4), ASMT(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(9), HADH(1), HEMK1(2), KMO(1), KYNU(1), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), NFX1(1), OGDHL(1), PRMT6(2), PRMT7(1), PRMT8(1), TDO2(1), TPH1(2), TPH2(2) 17743092 63 49 63 20 29 11 14 2 7 0 0.409 1.000 1.000 484 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP4A(1), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(1), OCRL(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CG(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5) 13395128 58 49 57 22 31 8 9 2 8 0 0.697 1.000 1.000 485 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(2), CDA(1), DHODH(2), DPYD(3), ENTPD1(3), ENTPD6(1), NME1(1), NME6(1), NT5C1B(1), NT5C2(1), POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1), PRIM2(2), RFC5(2), RRM1(1), TK1(1), TK2(1), TXNRD1(1), UCK2(1), UMPS(1), UPB1(1), UPRT(1) 24148757 54 48 54 19 23 9 11 5 6 0 0.617 1.000 1.000 486 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH5(1), AGK(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CEL(1), DAK(1), DGAT1(2), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), GK2(2), GLA(1), GLB1(2), GPAM(3), LCT(4), LIPA(2), LIPC(2), LPL(1), MGLL(1), PNLIP(1), PNLIPRP1(1), PNPLA3(1), PPAP2A(3), PPAP2C(3) 17556327 57 48 57 26 31 11 7 0 8 0 0.888 1.000 1.000 487 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 BDKRB2(3), CAV1(1), CHRNA1(2), FLT1(4), FLT4(4), KDR(8), NOS3(2), PDE3A(5), PRKACB(1), PRKAR2B(1), PRKG1(4), RYR2(24) 12433882 59 47 59 20 24 8 15 6 6 0 0.681 1.000 1.000 488 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CTLA4(1), EPHB2(4), FBXW7(1), GRAP2(2), ITPKB(1), LCK(3), LCP2(3), MAPK1(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIL1(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PLCG1(3), PTPRC(4), RAF1(1), RASGRP1(3), RASGRP2(2), RASGRP4(3), SOS1(4), SOS2(2), VAV1(3), ZAP70(1) 16867917 66 47 66 22 35 8 14 2 7 0 0.560 1.000 1.000 489 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(2), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), AOX1(4), ASMT(1), CYP2A13(2), CYP2A6(1), CYP2A7(3), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(1), DDC(1), ECHS1(1), EHHADH(9), KMO(1), KYNU(1), MAOA(2), MAOB(2), SDS(2), TDO2(1), TPH1(2) 16221304 58 47 58 15 23 8 12 4 11 0 0.240 1.000 1.000 490 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(2), ADH5(1), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH3A1(1), ALDH3B2(1), CYP1B1(1), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), DHDH(1), EPHX1(2), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTP1(2), GSTZ1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2A1(2), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2) 16963332 50 46 50 17 16 9 5 6 14 0 0.808 1.000 1.000 491 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(2), EGF(4), EGFR(4), ETS1(1), ETS2(1), FOS(2), IKBKB(3), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK14(2), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(1), PRKCG(1), PRKCH(2), PRKCQ(2), RAF1(1), RELA(1), RIPK1(2), SP1(2), TNF(2), TNFRSF1A(1) 13947059 50 46 50 19 23 5 13 0 9 0 0.794 1.000 1.000 492 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), ITGA9(4), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), MAP2K1(1), MAPK1(1), PAK1(1), PDE3A(5), PIK3C2G(5), PIK3CA(7), PIK3CD(4), PIK3R1(2), RIPK3(2), SGCB(1), VASP(1) 14634300 53 46 52 18 31 12 5 2 3 0 0.555 1.000 1.000 493 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 FOS(2), FYN(1), JUN(1), LCK(3), MAP2K1(1), MAP2K4(3), MAP3K1(2), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PPP3CA(4), PRKCA(1), RAF1(1), RASA1(4), RELA(1), SHC1(2), SOS1(4), VAV1(3), ZAP70(1) 13988959 58 46 57 17 30 6 9 4 9 0 0.432 1.000 1.000 494 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASS(2), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BBOX1(1), DLST(2), DOT1L(4), ECHS1(1), EHHADH(9), EHMT1(2), EHMT2(2), HADH(1), HSD3B7(1), NSD1(6), OGDHL(1), PIPOX(1), PLOD1(2), PLOD2(2), PLOD3(1), RDH12(1), RDH13(1), SETD1A(5), SETDB1(1), SHMT1(1), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(1) 16906044 62 45 62 18 28 14 7 6 7 0 0.264 1.000 1.000 495 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), AR(2), ESR1(4), ESR2(1), ESRRA(1), HNF4A(1), NPM1(1), NR1D1(1), NR1H2(1), NR1H3(2), NR1I2(1), NR2C2(1), NR2F2(2), NR3C1(2), NR4A1(2), NR4A2(3), NR5A2(1), PGR(3), PPARA(2), PPARD(1), RARA(1), RARG(3), ROR1(4), RXRA(5), RXRB(2), RXRG(1) 12475862 54 44 54 14 26 12 5 4 7 0 0.257 1.000 1.000 496 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(3), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GAA(1), GANAB(1), GPI(2), GUSB(3), GYS1(2), GYS2(1), HK1(1), HK2(4), HK3(3), MGAM(5), PGM3(2), PYGB(1), PYGL(1), PYGM(5), SI(4), UCHL1(1), UCHL3(1), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2B15(1), UGT2B4(4) 19817810 58 44 58 22 30 9 4 5 10 0 0.746 1.000 1.000 497 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B2(2), EIF2B5(1), EIF2S3(1), ELAVL1(3), FLT1(4), FLT4(4), HIF1A(1), KDR(8), NOS3(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(6), PXN(1), SHC1(2) 10250255 48 44 47 14 21 8 9 3 7 0 0.477 1.000 1.000 498 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAPK1(1), NFATC2(3), NFATC3(1), NFATC4(4), PIK3CA(7), PIK3R1(2), PLA2G4A(5), PLCG1(3), PPP3CA(4), RAF1(1), SHC1(2), SOS1(4), SYK(1), VAV1(3) 12482902 52 43 51 13 29 8 7 2 6 0 0.223 1.000 1.000 499 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), CDIPT(1), CHAT(4), CHKA(1), CPT1B(3), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), GNPAT(1), PAFAH2(1), PCYT1A(1), PCYT1B(1), PLA2G2E(1), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB2(2), PLCG1(3), PLCG2(5), PPAP2A(3), PPAP2C(3) 15048453 54 42 54 18 34 9 7 0 4 0 0.307 1.000 1.000 500 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 CALR(3), CREBBP(6), EDN1(2), ELSPBP1(2), F2(1), GSK3B(2), HAND2(1), LIF(1), MAP2K1(1), MAPK1(1), MAPK14(2), MEF2C(1), MYH2(3), NFATC2(3), NFATC3(1), NFATC4(4), PIK3CA(7), PIK3R1(2), PPP3CA(4), PRKACB(1), PRKAR2B(1), RAF1(1), RPS6KB1(1) 14706669 51 42 50 13 28 4 9 4 6 0 0.211 1.000 1.000 501 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CDA(1), DHODH(2), DPYD(3), ENTPD1(3), NME1(1), POLD1(2), POLE(3), POLG(4), POLQ(7), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), RRM1(1), TK1(1), TK2(1), TXNRD1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1) 17004868 48 42 48 15 23 12 6 2 5 0 0.400 1.000 1.000 502 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(2), ARSD(1), CYP11B1(1), CYP11B2(6), HEMK1(2), HSD17B3(1), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), SULT2B1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2A1(2), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2) 14350372 46 41 46 13 22 10 5 1 8 0 0.451 1.000 1.000 503 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(3), CANX(1), CD4(1), CD8B(1), CTSB(2), HLA-B(1), HLA-DMA(1), HLA-DMB(2), HLA-DPB1(1), HLA-E(3), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(3), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), KIR2DL1(1), KIR2DL3(4), LTA(1), NFYA(1), PSME2(1), RFX5(1), RFXAP(1), TAP1(2) 13930299 48 41 48 19 18 8 9 4 9 0 0.836 1.000 1.000 504 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 94 ANK2(4), DGKI(1), FAU(1), IL6ST(7), RPL11(1), RPL13(1), RPL18(1), RPL22(1), RPL27(1), RPL3(1), RPL4(1), RPL5(1), RPL7A(1), RPS10(1), RPS23(1), RPS27A(1), RPS3(1), RPS4Y1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS9(1), SLC36A2(3), UBC(1) 15290729 50 41 50 11 22 6 8 1 13 0 0.186 1.000 1.000 505 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), BCL2(1), CASP10(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CRADD(1), DFFB(1), FADD(2), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(11), RIPK1(2), TNF(2), TNFRSF1A(1), TRAF1(1), TRAF6(1) 12902028 46 40 46 14 22 8 10 2 4 0 0.444 1.000 1.000 506 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(4), ATP4A(5), ATP5A1(1), ATP5B(3), ATP5C1(1), ATP5G3(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), COX15(2), COX5A(2), COX5B(1), COX6B1(1), LHPP(1), NDUFA10(1), NDUFA5(1), NDUFV2(1), SDHA(3), SDHB(1), UQCRB(1) 16700317 45 40 45 20 22 8 9 3 3 0 0.876 1.000 1.000 507 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT2(3), AKT3(1), ARHGEF11(1), BCL2(1), CDC42(2), DLG4(2), GNA13(2), LPA(2), MAP2K4(3), MAP3K1(2), MAP3K5(2), NFKB1(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(6), ROCK1(3), ROCK2(3) 14972068 48 40 48 16 22 6 6 3 11 0 0.628 1.000 1.000 508 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), ASAH1(1), GNAI1(2), GNB1(1), ITGAV(5), MAPK1(1), PDGFA(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLCB1(5), PRKCA(1), PTK2(6), SMPD2(2), SPHK1(2), SRC(1) 7972604 44 39 43 10 21 8 8 1 6 0 0.240 1.000 1.000 509 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT(2), ALAS1(1), ALAS2(1), AMT(1), AOC2(2), AOC3(1), CBS(2), CHDH(2), CHKA(1), CTH(1), DAO(5), DLD(1), GARS(1), GATM(1), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), MAOB(2), PHGDH(2), PIPOX(1), PSAT1(2), RDH12(1), RDH13(1), SARDH(2), SARS(1), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(1) 12741427 52 39 52 14 30 7 7 2 6 0 0.149 1.000 1.000 510 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(4), AASS(2), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), BBOX1(1), DLST(2), DOT1L(4), ECHS1(1), EHHADH(9), EHMT1(2), EHMT2(2), PLOD1(2), PLOD2(2), PLOD3(1), SDS(2), SHMT1(1), SHMT2(2) 10729567 46 39 46 15 19 12 7 3 5 0 0.506 1.000 1.000 511 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(4), CREBBP(6), EP300(3), ERCC3(3), ESR1(4), GRIP1(3), GTF2E1(1), HDAC2(1), HDAC3(1), HDAC4(2), MEF2C(1), NCOR2(6), PELP1(4), POLR2A(5) 14064054 44 38 44 10 23 4 9 0 8 0 0.113 1.000 1.000 512 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(3), ACACB(6), ACAT1(1), ACAT2(4), ACOT12(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), DLAT(1), DLD(1), GLO1(2), HAGHL(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), ME2(1), ME3(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1) 13583621 45 38 45 18 23 7 7 3 5 0 0.712 1.000 1.000 513 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(2), DDIT3(1), HSPB2(3), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAPK14(2), MAPKAPK2(1), MAPKAPK5(2), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(5), RIPK1(2), RPS6KA5(1), SHC1(2), STAT1(2), TGFB2(2), TGFB3(2), TGFBR1(1) 11032671 44 38 44 12 22 5 10 1 6 0 0.370 1.000 1.000 514 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), AGPAT1(2), AGPAT3(2), AGPAT4(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), CEL(1), DGAT1(2), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), GLA(1), GLB1(2), LCT(4), LIPC(2), LPL(1), PNLIP(1), PNLIPRP1(1), PPAP2A(3), PPAP2C(3) 14469299 42 37 42 19 25 7 5 0 5 0 0.814 1.000 1.000 515 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT(2), ALAS1(1), ALAS2(1), AMT(1), AOC2(2), AOC3(1), CBS(2), CHDH(2), CHKA(1), CPT1B(3), CTH(1), DAO(5), DLD(1), GARS(1), GATM(1), GCAT(1), GLDC(2), MAOA(2), MAOB(2), PLCB2(2), PLCG1(3), PLCG2(5), SARDH(2), SARS(1), SHMT1(1), SHMT2(2), TARS(1) 12505561 51 37 51 13 31 6 8 1 5 0 0.100 1.000 1.000 516 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(1), ACADS(1), ACADVL(1), ACAT1(1), ACAT2(4), ACOX1(2), ACOX3(1), ACSL1(1), ACSL5(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CPT1A(3), CPT1B(3), CPT1C(2), CYP4A11(1), CYP4A22(2), ECHS1(1), EHHADH(9), HADH(1), HADHB(1) 14367857 46 37 46 13 19 11 8 2 6 0 0.384 1.000 1.000 517 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX15(2), CP(2), CPOX(1), EPRS(3), FECH(1), FTMT(2), GUSB(3), HCCS(1), HMBS(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A8(1), UGT1A9(1), UGT2A1(2), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2) 11956195 42 37 42 11 15 7 9 1 10 0 0.471 1.000 1.000 518 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(1), DLD(1), G6PC(1), GAPDHS(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), LDHAL6B(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PFKL(1), PFKP(2), PGAM1(1), PGK2(2) 12318377 39 36 39 15 22 7 2 1 7 0 0.664 1.000 1.000 519 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), FOS(2), GNAI1(2), GNAS(7), GNB1(1), JUN(1), MAP2K1(1), NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKACB(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(6) 10153159 42 36 40 10 23 5 8 1 5 0 0.201 1.000 1.000 520 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDH7A1(1), ALDOB(2), DLAT(1), DLD(1), G6PC(1), GAPDHS(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PDHB(1), PFKL(1), PFKP(2), PGAM1(1), PGK2(2), PGM3(2) 17096138 41 36 41 17 18 10 3 2 8 0 0.821 1.000 1.000 521 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(1), ACADS(1), ACAT1(1), ACAT2(4), ACSM1(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), HADH(1), HMGCS1(2), HSD3B7(1), PDHA1(1), PDHA2(3), PDHB(1), RDH12(1), RDH13(1) 12090847 44 36 44 16 19 12 7 3 3 0 0.634 1.000 1.000 522 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(5), ASAH1(1), CAMP(1), DLG4(2), EPHB2(4), GNAI1(2), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), PTX3(1), RHO(1), RYR1(9) 13691268 45 36 45 10 23 10 5 1 6 0 0.0939 1.000 1.000 523 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(1), AZIN1(1), CBX3(1), CLOCK(1), CRY1(3), DNAJA1(1), EIF4G2(5), GFRA1(1), GSTP1(2), HSPA8(1), IDI1(1), KLF9(1), NCKAP1(2), PER1(2), PER2(4), PPP2CB(1), PSMA4(2), SF3A3(1), TOB1(1), UCP3(2), ZFR(2) 10680501 36 35 36 10 22 2 6 2 4 0 0.221 1.000 1.000 524 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOX1(4), BCAT1(2), BCAT2(1), DBT(1), DLD(1), ECHS1(1), EHHADH(9), HADH(1), HADHB(1), HIBADH(1), HIBCH(4), HMGCS1(2), MCCC1(1), MUT(1), PCCB(2) 12926174 43 35 43 11 20 9 7 4 3 0 0.262 1.000 1.000 525 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(3), ACACB(6), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), ECHS1(1), EHHADH(9), HIBCH(4), LDHA(1), LDHAL6A(1), LDHAL6B(1), MUT(1), PCCB(2), SUCLG1(2) 11640485 40 35 40 11 18 8 8 3 3 0 0.296 1.000 1.000 526 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4), F10(3), F2(1), F5(4), F8(2), FGA(6), KLKB1(2), PROC(1), PROS1(2), SERPINC1(2) 13262023 43 35 42 12 18 9 8 2 6 0 0.410 1.000 1.000 527 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX5(2), CYP4F3(1), EPX(2), LPO(3), LTA4H(1), MPO(5), PLA2G2E(1), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PRDX1(1), PRDX2(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(9) 8350760 39 35 39 15 16 11 3 2 7 0 0.724 1.000 1.000 528 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP3K1(2), MAPK14(2), NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKCA(1), RAF1(1), SHC1(2), SOS1(4), SYK(1), VAV1(3) 11067845 39 34 39 10 26 4 6 2 1 0 0.184 1.000 1.000 529 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(2), MAP3K1(2), MAPK1(1), MAPK14(2), NCF2(1), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(5), PLCB1(5), PPP3CA(4), RAF1(1), RELA(1) 11489855 41 34 41 16 24 4 8 3 2 0 0.722 1.000 1.000 530 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(3), ABAT(1), ACY3(1), ADSL(1), ADSS(2), ADSSL1(1), AGXT(2), ASNS(3), ASRGL1(1), ASS1(2), CAD(2), CRAT(2), DDO(1), DLAT(1), DLD(1), GAD1(3), GAD2(1), GPT(1), PC(4), PDHA1(1), PDHA2(3), PDHB(1) 11177313 38 34 38 15 21 8 7 1 1 0 0.678 1.000 1.000 531 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(2), ALOX15B(2), ALOX5(2), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP4A11(1), CYP4A22(2), CYP4F3(1), DHRS4(1), EPHX2(1), GPX1(1), LTA4H(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PTGES(1), PTGS1(1), PTGS2(1), TBXAS1(1) 11793272 37 34 37 18 15 7 5 3 7 0 0.953 1.000 1.000 532 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GALT1(1), B3GNT2(1), B4GALNT1(1), B4GALT2(1), B4GALT3(2), B4GALT6(2), FUT1(2), FUT3(1), FUT9(2), GBGT1(1), GCNT2(1), PIGB(1), PIGC(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(4), PIGS(2), PIGV(1), PIGZ(2), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC5(2), ST8SIA1(1) 14419753 42 34 42 12 14 7 12 2 7 0 0.512 1.000 1.000 533 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLG(4), POLK(1), POLQ(7), PRIM2(2), REV1(4), REV3L(7), RFC5(2) 12181519 36 34 36 12 15 7 6 2 6 0 0.667 1.000 1.000 534 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR3(1), CDC42(2), CFL1(1), CFL2(1), FLNA(4), FLNC(3), FSCN1(2), MYH2(3), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), RHO(1), ROCK1(3), ROCK2(3), VASP(1), WASL(1) 14228555 42 34 42 16 21 5 10 1 5 0 0.723 1.000 1.000 535 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(1), ASCC3(6), ATP13A2(1), DDX18(1), DDX4(1), DDX41(1), DDX47(1), DDX50(4), DDX56(1), EP400(2), ERCC2(2), ERCC3(3), FPGS(2), MOV10L1(1), PTS(1), RAD54B(3), SETX(3), SKIV2L2(1), SMARCA2(3), SMARCA5(1) 18603789 42 33 42 15 23 8 4 2 5 0 0.644 1.000 1.000 536 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(2), FOS(2), IKBKB(3), IRAK1(2), JUN(1), LY96(1), MAP2K4(3), MAP3K1(2), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), PPARA(2), RELA(1), TLR10(1), TLR2(1), TLR3(1), TLR4(2), TLR7(2), TLR9(2), TRAF6(1) 10958129 37 33 37 11 18 6 7 2 4 0 0.493 1.000 1.000 537 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(2), AKT2(3), AKT3(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), NFKB1(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3) 13647504 39 32 39 15 19 8 5 2 5 0 0.698 1.000 1.000 538 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(1), ACO2(3), CLYBL(1), DLD(1), DLST(2), FH(2), IDH1(3), IDH2(4), IDH3G(1), OGDHL(1), PC(4), PCK1(5), SDHA(3), SDHB(1), SUCLG1(2) 8735404 36 31 34 10 22 5 5 2 2 0 0.250 1.000 1.000 539 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT2(1), G6PC(1), GAA(1), GALK1(2), GALT(1), GLA(1), GLB1(2), HK1(1), HK2(4), HK3(3), HSD3B7(1), LALBA(1), LCT(4), MGAM(5), PFKL(1), PFKP(2), PGM3(2), RDH12(1), RDH13(1) 11348662 35 31 35 18 20 5 2 3 5 0 0.892 1.000 1.000 540 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(1), DLST(2), FH(2), IDH2(4), IDH3G(1), PC(4), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PDK2(1), PDK3(2), PDK4(1), SDHA(3), SDHB(1), SUCLG1(2) 8408916 34 31 34 12 19 5 4 4 2 0 0.506 1.000 1.000 541 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(6), DUSP1(1), EP300(3), IKBKB(3), IL1B(1), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TLR2(1), TNF(2) 8714546 31 31 31 10 16 3 8 2 2 0 0.530 1.000 1.000 542 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDOB(2), DLAT(1), DLD(1), G6PC(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), PDHA1(1), PDHA2(3), PDHB(1), PFKP(2), PGAM1(1), PGM3(2) 14320385 34 30 34 17 17 7 1 2 7 0 0.911 1.000 1.000 543 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDOB(2), DLAT(1), DLD(1), G6PC(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), PDHA1(1), PDHA2(3), PDHB(1), PFKP(2), PGAM1(1), PGM3(2) 14320385 34 30 34 17 17 7 1 2 7 0 0.911 1.000 1.000 544 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(2), FPGT(2), GMPPA(3), HK1(1), HK2(4), HK3(3), HSD3B7(1), LHPP(1), MPI(1), MTMR1(1), MTMR6(2), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(1), PFKP(2), PGM2(1), PHPT1(1), PMM1(1), RDH12(1), RDH13(1), SORD(1) 11115344 36 30 36 14 20 7 1 3 5 0 0.679 1.000 1.000 545 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), DRD2(1), DRD3(1), DRD5(2), HRH2(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5) 7442989 37 30 37 14 16 5 9 3 4 0 0.605 1.000 1.000 546 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(2), CCR2(3), CCR3(1), CCR7(4), CD4(1), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18R1(1), IL4(1), IL4R(1), TGFB2(2), TGFB3(2) 5940840 38 30 38 11 14 6 13 1 4 0 0.403 1.000 1.000 547 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), EDN1(2), EDNRA(3), EDNRB(1), EGF(4), EGFR(4), FOS(2), JUN(1), MYC(1), NFKB1(2), PLCG1(3), PRKCA(1), RELA(1) 5976978 31 29 31 11 17 2 6 1 5 0 0.602 1.000 1.000 548 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CD97(1), CRHR1(3), CRHR2(3), ELTD1(6), EMR1(2), EMR2(1), GLP1R(2), GLP2R(3), GPR64(1), LPHN1(5), LPHN2(2), LPHN3(4), VIPR2(1) 8256113 36 29 36 12 15 10 6 0 5 0 0.542 1.000 1.000 549 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), CAD(2), CPS1(6), EPRS(3), GAD1(3), GAD2(1), GFPT2(1), GLS(1), GLUD1(2), GLUD2(3), GLUL(1), GMPS(2), GPT(1), GSR(2), NADSYN1(1), NAGK(1), PPAT(1) 11587680 33 29 33 11 16 6 6 2 3 0 0.530 1.000 1.000 550 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(1), FUCA2(1), GLB1(2), GUSB(3), HEXA(1), HGSNAT(2), HPSE(1), HPSE2(1), HYAL1(1), IDUA(2), LCT(4), MAN2B2(2), MAN2C1(2), NAGLU(1), NEU1(3), NEU2(3), NEU3(2), SPAM1(3) 10426778 35 29 35 13 18 6 8 0 3 0 0.586 1.000 1.000 551 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(4), ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), ATP7A(2), ATP7B(3), COX5A(2), COX5B(1), COX6B1(1), NDUFA10(1), NDUFA5(1), NDUFV2(1), SDHA(3), SDHB(1), SHMT1(1), UQCRB(1) 11283338 32 29 32 10 14 4 8 2 4 0 0.576 1.000 1.000 552 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(3), ACAT1(1), ACAT2(4), ADH5(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), DLAT(1), DLD(1), GLO1(2), HAGHL(1), LDHA(1), ME2(1), ME3(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1) 10749373 34 29 34 15 19 4 5 1 5 0 0.826 1.000 1.000 553 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CDC42(2), CREB3(1), CREB5(1), DUSP1(1), EEF2K(1), IL1R1(3), MAP2K4(3), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK14(2), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(1) 10066325 32 29 32 15 17 2 2 2 9 0 0.871 1.000 1.000 554 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), G6PC(1), GAA(1), GALK1(2), GALT(1), GANAB(1), GLA(1), GLB1(2), HK1(1), HK2(4), HK3(3), LALBA(1), LCT(4), MGAM(5), PFKP(2), PGM3(2) 9588272 32 28 32 16 19 5 1 3 4 0 0.831 1.000 1.000 555 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(4), GABBR1(5), GPRC5A(1), GPRC5B(1), GRM1(3), GRM2(2), GRM3(5), GRM4(2), GRM5(3), GRM7(3), GRM8(5) 6086864 34 28 33 11 15 9 7 0 3 0 0.411 1.000 1.000 556 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG13(2), ALG2(1), ALG3(1), ALG5(1), ALG6(1), ALG8(1), ALG9(3), B4GALT2(1), B4GALT3(2), DPAGT1(1), FUT8(1), GANAB(1), MAN1A1(1), MAN1A2(2), MAN1C1(1), MAN2A1(3), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2), MGAT5B(2) 12594480 33 28 33 15 18 7 2 1 5 0 0.724 1.000 1.000 557 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(2), CREBBP(6), EP300(3), FADD(2), HDAC3(1), IKBKB(3), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TRAF6(1) 6732620 28 28 28 12 16 4 6 0 2 0 0.757 1.000 1.000 558 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(4), EGFR(4), MAP2K1(1), MAPK1(1), PTPRB(6), RAF1(1), RASA1(4), SHC1(2), SOS1(4), SPRY2(1), SPRY3(1), SRC(1) 7377395 31 28 31 12 13 2 8 2 6 0 0.782 1.000 1.000 559 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(6), EEF1A2(1), EEF1G(1), EEF2K(1), EIF2AK2(1), EIF2AK3(2), EIF2B2(2), EIF2B5(1), EIF2S3(1), EIF4A2(1), EIF4G1(4), EIF4G3(4), EIF5A(2), ETF1(1), PABPC1(1), PABPC3(2) 13048773 31 28 31 10 16 3 6 1 5 0 0.521 1.000 1.000 560 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOX1(4), BCAT1(2), ECHS1(1), EHHADH(9), HADHB(1), HIBADH(1), MCCC1(1), MUT(1), PCCB(2), SDS(2) 10693893 35 28 35 13 15 8 6 2 4 0 0.757 1.000 1.000 561 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1), SDS(2) 7562825 33 27 33 11 16 8 5 2 2 0 0.542 1.000 1.000 562 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(3), ACADL(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), LDHA(1), MUT(1), PCCB(2), SDS(2), SUCLG1(2) 9727258 31 26 31 11 16 5 6 1 3 0 0.613 1.000 1.000 563 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA3(2), ANXA4(1), ANXA6(2), CYP11A1(1), EDN1(2), EDNRA(3), EDNRB(1), HPGD(2), PLA2G4A(5), PRL(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2), PTGS1(1), PTGS2(1), TBXAS1(1) 6427300 29 26 29 12 13 8 5 2 1 0 0.805 1.000 1.000 564 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(7), BMPR1B(1), CCND2(1), ESR2(1), INHA(2), LHCGR(4), MLH1(1), MSH5(3), NCOR1(2), PGR(3), PTGER2(1), ZP2(1) 10070766 27 25 27 14 8 4 7 2 6 0 0.966 1.000 1.000 565 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(2), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), NOS1(9), PPP3CA(4), PRKACB(1), PRKAR2B(1), PRKCA(1) 7556725 27 24 27 15 17 3 3 0 4 0 0.906 1.000 1.000 566 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(4), ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP2A13(2), CYP2A6(1), CYP2A7(3), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(1) 8745353 26 23 26 13 10 3 4 2 7 0 0.933 1.000 1.000 567 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CDH1(2), CREBBP(6), EP300(3), MAP2K1(1), MAP3K7(1), SKIL(1), TGFB2(2), TGFB3(2), TGFBR1(1) 7548373 24 23 24 10 12 1 7 0 4 0 0.703 1.000 1.000 568 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 21 F10(3), F13B(1), F2(1), F5(4), F8(2), FGA(6), LPA(2), PLAU(1), SERPINB2(1), SERPINE1(1), VWF(5) 10615945 27 22 26 12 13 4 5 2 3 0 0.831 1.000 1.000 569 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), CAD(2), CPS1(6), EPRS(3), GAD1(3), GAD2(1), GLS(1), GLUD1(2), GLUL(1), GMPS(2), GPT(1), NADSYN1(1), PPAT(1) 9793942 25 22 25 10 12 5 3 2 3 0 0.731 1.000 1.000 570 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(2), MAP3K1(2), MYC(1), NFATC2(3), NFKB1(2), NFKBIA(2), PLCG1(3), PPP3CA(4), PRKACB(1), PRKAR2B(1), RELA(1), VIPR2(1) 8071783 23 22 23 10 14 1 4 1 3 0 0.777 1.000 1.000 571 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ADSL(1), ADSS(2), AGXT(2), ASNS(3), CAD(2), CRAT(2), DDO(1), GAD1(3), GAD2(1), GPT(1), PC(4) 7664034 23 21 23 12 13 4 5 1 0 0 0.892 1.000 1.000 572 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC27(1), CUL1(1), CUL2(1), FBXW11(1), FBXW7(1), FZR1(2), SKP2(1), SMURF1(2), UBA1(3), UBE2D3(2), WWP2(2) 12212683 21 21 21 11 11 2 2 1 5 0 0.913 1.000 1.000 573 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(3), ACACB(6), FASN(10), MCAT(1), OXSM(2) 4815743 22 20 22 12 13 3 2 1 3 0 0.864 1.000 1.000 574 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CDC42(2), CHUK(2), MAP2K1(1), NFKB1(2), PIK3CA(7), PIK3R1(2), RAF1(1), RALBP1(1), RALGDS(1), RELA(1) 5762407 20 20 19 12 12 3 1 0 4 0 0.959 1.000 1.000 575 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1R(1), C1S(1), C2(1), C3(8), C4A(1), C5(3), C6(1), C7(1), C9(2), MASP2(1) 10352733 22 19 22 10 9 2 3 3 5 0 0.888 1.000 1.000 576 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), LCT(4), MAN2B2(2), MAN2C1(2), NEU1(3), NEU2(3), NEU3(2) 6114788 21 19 21 6 13 3 5 0 0 0 0.331 1.000 1.000 577 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(1), CMAS(1), CYB5R3(1), GFPT2(1), GNE(1), HEXA(1), HK1(1), HK2(4), HK3(3), LHPP(1), MTMR1(1), MTMR6(2), NAGK(1), NPL(1), PGM3(2), PHPT1(1) 8484062 23 19 23 15 11 3 2 3 4 0 0.979 1.000 1.000 578 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(3), LPL(1), NCOA1(2), NCOA2(4), RXRA(5) 5375278 21 19 21 6 12 3 5 1 0 0 0.415 1.000 1.000 579 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(1), CASP8(1), FADD(2), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAPK1(1), NFKB1(2), RAF1(1), RELA(1), RIPK1(2), TNFRSF1A(1) 5951797 19 18 19 10 10 2 2 0 5 0 0.919 1.000 1.000 580 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(3), CARS2(1), EPRS(3), FARSB(1), GARS(1), HARS(1), HARS2(1), IARS(1), IARS2(2), MARS(3), MARS2(1), PARS2(1), SARS(1), SARS2(3), TARS(1), TARS2(1) 15877614 25 18 25 13 9 4 5 4 3 0 0.927 1.000 1.000 581 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), GPI(2), H6PD(1), PFKL(1), PFKP(2), PGD(1), PGM3(2), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL1(2), TKTL2(3) 7153744 19 17 19 11 7 4 3 2 3 0 0.938 1.000 1.000 582 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(2), EPHB1(3), FYN(1), ITGA1(3), ITGB1(1), L1CAM(3), LYN(1), SELP(1) 4626865 15 15 15 7 6 3 3 3 0 0 0.872 1.000 1.000 583 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(3), CPT1A(3), LEP(1), LEPR(3), PRKAA1(3), PRKAB2(1), PRKAG2(1) 4223612 15 15 15 9 9 2 3 1 0 0 0.898 1.000 1.000 584 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), GPI(2), H6PD(1), PFKP(2), PGD(1), PGM3(2), PRPS1L1(1), PRPS2(1), TALDO1(1) 5904190 13 12 13 12 4 2 2 2 3 0 0.996 1.000 1.000 585 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD4(1), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4) 3256581 11 11 11 5 8 1 2 0 0 0 0.737 1.000 1.000 586 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), GNAS(7), XPO1(1) 2811750 11 10 9 5 5 3 3 0 0 0 0.875 1.000 1.000 587 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(1), ENDOG(1), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(3) 3123031 10 10 10 4 4 2 2 2 0 0 0.794 1.000 1.000 588 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(2), NFKB1(2), RELA(1), TNFSF13B(1), TRAF5(1), TRAF6(1) 4238242 10 10 10 6 9 1 0 0 0 0 0.824 1.000 1.000 589 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD4(1), FYN(1), LCK(3), PTPRC(4), ZAP70(1) 2674023 10 10 10 4 3 3 3 1 0 0 0.785 1.000 1.000 590 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(3), AFMID(2), MTHFD1(1), MTHFD1L(1) 3926346 8 8 8 5 4 1 3 0 0 0 0.886 1.000 1.000 591 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), IFNAR1(1), IFNB1(1), NFKB1(2), RELA(1), TNFRSF11A(1), TRAF6(1) 3169787 9 8 9 7 6 0 2 1 0 0 0.951 1.000 1.000 592 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), PC(4), PDHA1(1) 2671601 7 7 7 6 6 1 0 0 0 0 0.928 1.000 1.000 593 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(3), MTHFD1(1), MTHFD1L(1) 3743736 6 6 6 3 3 1 2 0 0 0 0.805 1.000 1.000 594 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(3), GAD2(1) 1733721 6 6 6 5 3 1 0 2 0 0 0.966 1.000 1.000 595 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 MAP2K1(1), MAP2K2(2), MAPK1(1), NGFR(1), RAF1(1) 2444746 6 5 6 4 3 0 3 0 0 0 0.910 1.000 1.000 596 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), IL4(1), IL6(2), IL7(1) 1849957 5 5 5 3 1 2 2 0 0 0 0.900 1.000 1.000 597 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(1), ST8SIA1(1) 1624124 4 4 4 3 2 0 2 0 0 0 0.913 1.000 1.000 598 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), UGDH(1) 2493019 4 4 4 3 1 2 1 0 0 0 0.912 1.000 1.000 599 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDK7(1), XPO1(1) 2539181 4 4 4 2 2 1 1 0 0 0 0.850 1.000 1.000 600 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1B1(1), ALDH3A1(1) 2329340 3 3 3 4 0 2 1 0 0 0 0.987 1.000 1.000 601 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(1), IL4(1) 1163127 3 3 3 2 0 1 2 0 0 0 0.946 1.000 1.000 602 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1B1(1), ALDH3A1(1) 2329340 3 3 3 4 0 2 1 0 0 0 0.987 1.000 1.000 603 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASS(2) 1381915 3 3 3 2 3 0 0 0 0 0 0.852 1.000 1.000 604 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1), BCMO1(2) 1106116 3 3 3 2 1 2 0 0 0 0 0.901 1.000 1.000 605 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(1), HSD17B3(1) 2373995 3 3 3 3 2 1 0 0 0 0 0.923 1.000 1.000 606 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1) 691339 1 1 1 2 0 1 0 0 0 0 0.988 1.000 1.000 607 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1) 1939112 1 1 1 4 0 0 1 0 0 0 0.998 1.000 1.000 608 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1) 1939112 1 1 1 4 0 0 1 0 0 0 0.998 1.000 1.000 609 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(1) 2539865 1 1 1 4 1 0 0 0 0 0 0.998 1.000 1.000 610 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD4(1) 951949 1 1 1 2 0 1 0 0 0 0 0.989 1.000 1.000 611 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 491727 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 765703 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 629422 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 478914 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 2396715 0 0 0 5 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 340238 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000