rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(9), CDKN2A(30), E2F1(3), MDM2(6), MYC(2), PIK3CA(94), PIK3R1(7), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), RAC1(4), RB1(73), TBX2(7), TP53(226)	11787713	493	271	310	38	182	13	102	37	151	8	<1.00e-15	<1.00e-15	<1.48e-13
2	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(7), ATM(65), BAX(2), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), CDKN1A(38), E2F1(3), GADD45A(1), MDM2(6), PCNA(4), RB1(73), TP53(226)	10569238	439	266	312	31	118	9	95	30	173	14	1.07e-12	<1.00e-15	<1.48e-13
3	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), RB1(73), SKP2(5), TFDP1(2)	4966858	111	101	99	9	29	1	8	5	62	6	0.000161	<1.00e-15	<1.48e-13
4	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(3), HSPA1A(3), IFNG(2), IFNGR1(1), IFNGR2(6), IKBKB(11), JAK2(8), LIN7A(3), NFKB1(3), NFKBIA(6), RB1(73), RELA(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226), USH1C(10), WT1(4)	10415274	380	237	263	31	112	7	91	22	140	8	6.85e-14	1.33e-15	1.48e-13
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(4), MYC(2), SP1(10), SP3(3), TP53(226), WT1(4)	4101874	249	205	141	21	69	6	80	21	71	2	3.73e-09	1.33e-15	1.48e-13
6	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(16), AKT1(3), ATM(65), BAX(2), CDKN1A(38), CPB2(5), CSNK1A1(6), CSNK1D(3), FHL2(4), GADD45A(1), HIF1A(6), HSPA1A(3), IGFBP3(1), MAPK8(5), MDM2(6), NFKBIB(6), TP53(226)	12077203	396	261	276	37	124	11	102	32	119	8	2.30e-09	1.44e-15	1.48e-13
7	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(50), DAXX(9), HRAS(21), PAX3(11), PML(14), RARA(6), RB1(73), SIRT1(9), SP100(13), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226)	10972480	447	258	318	32	119	5	124	30	160	9	<1.00e-15	2.11e-15	1.86e-13
8	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(65), ATR(32), CDC25C(2), CHEK1(3), CHEK2(11), TP53(226), YWHAH(2)	9369284	341	240	229	22	113	10	92	34	88	4	1.12e-10	3.00e-15	2.13e-13
9	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CDK2(1), CDK4(6), CHEK1(3), MYT1(10), RB1(73), TP53(226), WEE1(10), YWHAH(2)	10260649	405	252	287	31	112	10	93	32	149	9	8.30e-12	3.11e-15	2.13e-13
10	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(9), ATM(65), ATR(32), CCNA1(4), CCND1(4), CCNE1(3), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), E2F1(3), GSK3B(5), HDAC1(4), RB1(73), SKP2(5), TFDP1(2), TGFB1(3), TGFB3(1), TP53(226)	17514723	533	279	396	42	158	15	113	39	193	15	2.11e-15	4.22e-15	2.45e-13
11	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(7), DNAJC3(6), EIF2S1(5), EIF2S2(1), NFKB1(3), NFKBIA(6), RELA(6), TP53(226)	5652096	260	206	152	13	82	5	81	17	73	2	2.19e-13	4.66e-15	2.45e-13
12	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CCND1(4), CDK2(1), CDK4(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CFL1(1), E2F1(3), E2F2(4), MDM2(6), PRB1(2), TP53(226)	4836827	328	232	203	24	89	7	93	18	114	7	6.20e-13	4.77e-15	2.45e-13
13	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), FBXW7(38), RB1(73), TFDP1(2)	4802111	140	119	118	11	36	1	18	5	74	6	2.71e-05	6.00e-15	2.84e-13
14	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), E2F1(3), RB1(73), RBL1(9), TFDP1(2)	9246340	219	158	193	22	60	6	24	9	109	11	6.34e-05	3.59e-12	1.58e-10
15	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN1B(6), E2F1(3), HRAS(21), MAPK3(8), NFKB1(3), NFKBIA(6), PAK1(4), PIK3CA(94), PIK3R1(7), RAC1(4), RAF1(4), RB1(73), RELA(6), TFDP1(2)	11750042	301	205	217	31	125	7	29	24	105	11	1.30e-07	8.32e-08	3.42e-06
16	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(1), CDKN1B(6), CUL1(19), E2F1(3), NEDD8(2), RB1(73), RBX1(1), SKP2(5), TFDP1(2), UBE2M(3)	4996097	118	100	106	14	32	1	8	6	65	6	0.00299	2.30e-07	8.85e-06
17	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(5), AKT3(8), CDKN1A(38), ELK1(1), GRB2(3), HRAS(21), MAP2K1(3), MAP2K2(5), NGFR(4), NTRK1(7), PIK3CA(94), PIK3CD(7), SHC1(8), SOS1(23)	9361623	230	160	154	27	122	4	35	26	38	5	1.77e-06	7.98e-06	0.000289
18	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(9), ATM(65), BRCA1(23), CDKN1A(38), CHEK1(3), CHEK2(11), GADD45A(1), JUN(4), MAPK8(5), MDM2(6), MRE11A(7), NFKB1(3), NFKBIA(6), RAD50(13), RAD51(7), RBBP8(11), RELA(6), TP53(226), TP73(6)	17377980	450	276	327	39	163	10	107	35	127	8	8.39e-10	1.28e-05	0.000439
19	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(5), CDC25B(2), CDK7(6), CDKN1A(38), CHEK1(3), NEK1(5), WEE1(10)	3964352	69	57	61	8	24	5	3	0	32	5	0.415	9.16e-05	0.00297
20	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), NFYB(1), NFYC(1), RB1(73), SP1(10), SP3(3)	3897027	90	81	83	12	12	2	1	6	63	6	0.0694	0.000157	0.00484
21	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), CASP3(3), CASP6(1), CASP7(5), CASP9(6), CYCS(1), EIF2S1(5), PRKCA(3), PTK2(15), PXN(3), STAT1(13), TLN1(17), TP53(226)	15945862	384	249	271	42	134	14	103	31	99	3	1.72e-09	0.000301	0.00884
22	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(9), GH1(3), GHR(6), HRAS(21), IGF1(2), IGF1R(11), PIK3CA(94), PIK3R1(7), SHC1(8), SOD1(4), SOD2(1), SOD3(1)	7753212	170	134	103	22	93	3	36	22	16	0	2.95e-05	0.00167	0.0467
23	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), EGFR(7), IGF1R(11), MYC(2), POLR2A(13), PPP2CA(2), PRKCA(3), RB1(73), TEP1(14), TERF1(5), TERT(4), TNKS(6), TP53(226), XRCC5(1)	16355141	370	235	255	48	97	6	102	24	133	8	3.71e-09	0.00239	0.0641
24	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(7), RAC1(4), WASL(2)	7841607	151	125	92	17	95	5	15	19	17	0	0.000102	0.0219	0.562
25	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(4), CD3E(2), CD3G(2), CD80(2), CD86(6), CTLA4(1), GRB2(3), HLA-DRA(4), HLA-DRB1(1), ICOS(2), IL2(1), ITK(6), LCK(2), PIK3CA(94), PIK3R1(7), PTPN11(4)	7502326	141	115	82	16	91	4	18	21	7	0	4.49e-05	0.0249	0.615
26	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(50), EP300(77), ESR1(5), MAPK3(8), PELP1(5), SRC(5)	8473831	150	120	142	22	46	6	27	17	52	2	0.00182	0.0580	1.000
27	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(3), CHRNB1(6), CHRNG(2), MUSK(9), PIK3CA(94), PIK3R1(7), PTK2(15), PTK2B(6), RAPSN(2), SRC(5), TERT(4), YWHAH(2)	9421423	158	122	99	21	96	11	19	19	13	0	4.99e-06	0.105	1.000
28	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(3), CASP9(6), CHUK(7), GH1(3), GHR(6), NFKB1(3), NFKBIA(6), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), RELA(6), YWHAH(2)	8186059	150	115	91	18	99	7	15	16	13	0	0.000246	0.206	1.000
29	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(5), AKT3(8), BPNT1(2), GRB2(3), ILK(3), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PTEN(16), PTK2B(6), RBL2(9), SHC1(8), SOS1(23)	11890301	197	149	136	25	126	6	23	25	17	0	6.85e-06	0.418	1.000
30	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(8)	1005449	8	8	8	0	3	0	3	0	2	0	0.130	0.493	1.000
31	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(3)	1188571	10	10	10	2	3	0	6	0	1	0	0.372	0.587	1.000
32	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(6), CDKN1B(6), GRB2(3), ILK(3), ITGB1(3), MAPK3(8), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PTEN(16), PTK2(15), SHC1(8), SOS1(23)	11221555	199	150	138	24	125	8	22	22	22	0	6.47e-05	0.656	1.000
33	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(3), HRAS(21), PTK2B(6), SHC1(8), SOS1(23), SRC(5)	5118084	66	53	57	9	28	1	21	7	9	0	0.0160	0.680	1.000
34	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), GRB2(3), HRAS(21), KLK2(1), NTRK1(7), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), SHC1(8), SOS1(23)	9107325	182	145	114	29	110	4	32	22	14	0	0.000571	0.690	1.000
35	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(94), PIK3R1(7), PLCB1(17), PLCG1(12), PRKCA(3), VAV1(8)	7511540	144	120	85	21	98	4	18	17	7	0	0.000732	0.702	1.000
36	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(5), LIPT1(1)	897135	6	5	6	0	4	1	1	0	0	0	0.293	0.735	1.000
37	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NFS1(5), THTPA(2), TPK1(4)	3725882	35	32	35	4	20	0	5	5	5	0	0.0696	0.750	1.000
38	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(65), ATR(32), BRCA1(23), CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CDC34(1), CDKN1A(38), CDKN2D(1), CHEK1(3), CHEK2(11), EP300(77), GADD45A(1), MDM2(6), MYT1(10), PRKDC(35), RPS6KA1(5), TP53(226), WEE1(10), YWHAH(2), YWHAQ(3)	24351420	563	290	438	59	195	21	125	52	160	10	2.56e-10	0.763	1.000
39	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4)	3308380	25	24	25	3	11	1	6	2	5	0	0.0653	0.784	1.000
40	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	299386	1	1	1	0	1	0	0	0	0	0	0.748	0.790	1.000
41	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(3), FMOD(3), KERA(7), LUM(2)	2112006	17	16	17	2	9	0	5	2	1	0	0.0853	0.802	1.000
42	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(9), IFNG(2), IL12A(1), IL12B(3), IL2(1)	1737741	16	16	16	3	9	0	4	1	2	0	0.326	0.837	1.000
43	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(2), TAT(5), TYR(12)	2741084	27	23	27	4	12	1	9	1	4	0	0.0860	0.846	1.000
44	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(3), GNB1(7), HTR2C(1), PLCB1(17), TUB(4)	4164702	34	31	33	4	19	2	9	3	1	0	0.0217	0.876	1.000
45	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(3), CCND1(4), CCNE1(3), CCNE2(8), CDK2(1), CDK4(6), CDKN1B(6), CDKN2A(30), E2F1(3), E2F2(4), E2F4(2), PRB1(2)	5142241	76	60	67	11	32	5	13	2	24	0	0.0308	0.877	1.000
46	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(12), SPCS3(1)	1788894	15	15	15	4	7	1	4	1	2	0	0.394	0.887	1.000
47	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4E(2), EIF4EBP1(1), GSK3B(5), IGF1(2), IGF1R(11), INPPL1(11), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4)	11452183	190	143	130	26	118	4	26	18	23	1	5.08e-05	0.902	1.000
48	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(4), CD4(3), HLA-DRA(4), HLA-DRB1(1)	1383675	12	12	12	4	6	1	3	2	0	0	0.498	0.946	1.000
49	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(4), BIRC3(3), CASP8(14), FADD(7), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	4817772	57	49	55	9	36	1	7	4	9	0	0.0280	0.946	1.000
50	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(6), IDI1(2), SQLE(4)	1843674	12	12	12	2	6	0	3	2	1	0	0.313	0.969	1.000
51	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	664914	4	3	4	3	1	0	2	0	1	0	0.943	0.975	1.000
52	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(6), CES1(4), ESD(3)	3501402	18	18	18	3	7	0	5	4	2	0	0.191	0.988	1.000
53	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(5)	1526099	7	7	7	2	4	0	0	1	2	0	0.615	0.989	1.000
54	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(7), CPS1(13), GLS(4), GLUD1(6), GOT1(2)	4538906	34	28	32	5	18	1	5	5	5	0	0.0719	0.992	1.000
55	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL5(1)	1774605	10	10	10	4	3	0	4	2	1	0	0.723	0.996	1.000
56	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(10), NR0B2(2), NR1H3(4), NR1H4(4), RXRA(25)	3161192	46	41	33	10	22	3	10	2	9	0	0.0802	0.998	1.000
57	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(2), HGD(4)	1306225	9	9	9	4	5	0	0	2	2	0	0.814	0.998	1.000
58	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(7), CYP11A1(1), CYP11B2(13), CYP17A1(3), HSD11B2(3), HSD3B1(5), HSD3B2(5)	4025170	37	32	37	8	19	1	13	4	0	0	0.0452	0.998	1.000
59	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDPS(6), HMGCR(7), IDI1(2), LSS(7), MVD(4), NQO2(3), PMVK(1), SQLE(4), VKORC1(4)	6362305	41	36	41	5	22	2	7	5	5	0	0.0123	0.999	1.000
60	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5)	5333840	48	39	48	9	24	3	15	5	1	0	0.0186	0.999	1.000
61	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5)	5333840	48	39	48	9	24	3	15	5	1	0	0.0186	0.999	1.000
62	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(5), CCL2(1), CSF1(4), IL6(4), LDLR(10), LPL(4)	3116487	28	28	28	7	14	0	4	2	8	0	0.364	0.999	1.000
63	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(2)	1229445	5	5	5	3	1	1	2	1	0	0	0.889	0.999	1.000
64	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(3), ANXA1(5), CALM1(2), CALM2(2), GNAS(12), GNB1(7), NFKB1(3), NOS3(11), NPPA(2), NR3C1(6), PIK3CA(94), PIK3R1(7), RELA(6), SYT1(6)	10354522	169	135	108	27	118	8	15	17	11	0	0.00395	0.999	1.000
65	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(3), UGDH(5), UGP2(9), UXS1(3)	2849723	23	21	21	5	9	3	3	3	5	0	0.411	1.000	1.000
66	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(38), EPO(2), EPOR(5), GRIN1(9), HIF1A(6), JAK2(8), NFKB1(3), NFKBIA(6), RELA(6), SOD2(1)	7299863	93	80	84	15	40	3	9	3	33	5	0.214	1.000	1.000
67	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(6), JAK1(9), JAK2(8), STAT1(13)	4799687	39	35	38	7	17	1	7	3	11	0	0.182	1.000	1.000
68	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), KLK2(1), MAP2K1(3), MAPK3(8), MAPK8(5), NGFR(4), PIK3CA(94), PIK3R1(7), PLCG1(12), RAF1(4), SHC1(8), SOS1(23)	11130377	213	153	143	30	124	7	33	28	21	0	4.00e-05	1.000	1.000
69	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(2), SNAP25(4), STX1A(1), VAMP2(1)	1901498	10	10	10	4	5	1	3	1	0	0	0.634	1.000	1.000
70	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(4), GLUD1(6), GLUD2(10)	2657960	24	22	23	6	10	1	7	2	4	0	0.481	1.000	1.000
71	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(65), ATR(32), BRCA1(23), BRCA2(49), CHEK1(3), CHEK2(11), FANCA(18), FANCC(9), FANCD2(19), FANCE(3), FANCF(4), FANCG(5), HUS1(1), MRE11A(7), RAD1(3), RAD17(6), RAD50(13), RAD51(7), RAD9A(2), TP53(226), TREX1(8)	25798997	514	268	399	53	208	21	119	49	112	5	1.24e-09	1.000	1.000
72	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(4), CD4(3), CD80(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(1)	2318348	16	16	16	5	9	1	4	2	0	0	0.422	1.000	1.000
73	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(7), ITGB1(3), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(3), MAPK3(8), PAK1(4), PIK3CA(94), PIK3R1(7), PTK2B(6), PTPN6(2), RAC1(4), SYK(8), VAV1(8)	10835754	166	134	106	28	100	5	19	22	20	0	0.00351	1.000	1.000
74	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(5), ACAT2(1), HMGCL(1), OXCT1(4)	1983004	11	10	11	7	7	1	0	1	2	0	0.975	1.000	1.000
75	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT2(6), FUT3(3), FUT5(5), FUT6(2), ST3GAL3(3)	2957408	22	21	21	6	13	0	7	0	2	0	0.230	1.000	1.000
76	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(5), BLVRB(1), HMOX1(3), IL10(1), IL10RA(9), IL10RB(9), IL1A(1), IL6(4), JAK1(9), STAT1(13), STAT3(6), STAT5A(1), TNF(4)	7122262	66	56	65	12	29	0	12	3	22	0	0.0107	1.000	1.000
77	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), RAC1(4), WASF1(5), WASL(2)	4739468	39	35	39	7	19	3	5	4	8	0	0.207	1.000	1.000
78	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(3), BCL2L1(4), CASP9(6), CDC42(4), CHUK(7), ELK1(1), H2AFX(3), HRAS(21), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(7), RAC1(4), RAF1(4), RALA(2), RALBP1(2), RALGDS(4), RELA(6), RHOA(19)	11021344	208	149	136	33	119	8	32	24	25	0	0.000491	1.000	1.000
79	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(3), GGT1(5), SHMT1(3), SHMT2(2)	2375220	13	11	13	9	5	0	5	0	3	0	0.936	1.000	1.000
80	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(3), HRAS(21), MAPK3(8), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), NTRK1(7), PIK3CA(94), PIK3R1(7), PLCG1(12), RPS6KA1(5), SHC1(8)	10984337	189	145	122	32	110	7	37	17	18	0	0.000149	1.000	1.000
81	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TPO(16), TYR(12)	5592311	63	50	62	14	30	3	19	4	6	1	0.0579	1.000	1.000
82	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(1), RAB3A(2), RAB5A(2), RAB6A(5), RAB9A(1)	2475444	17	15	17	6	7	2	2	3	3	0	0.791	1.000	1.000
83	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(6), AKT1(3), BAD(3), BAX(2), BCL2L1(4), CSF2RB(5), IGF1(2), IGF1R(11), IL3RA(6), KIT(9), KITLG(5), PIK3CA(94), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), YWHAH(2)	12778665	181	136	121	30	97	8	27	23	26	0	0.000106	1.000	1.000
84	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(3), FDPS(6), HMGCR(7), HMGCS1(9), IDI1(2), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4)	7606406	50	44	50	8	28	2	8	8	4	0	0.0289	1.000	1.000
85	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(50), EP300(77), FYN(7), IL2RG(5), IL7(1), IL7R(7), JAK1(9), JAK3(12), LCK(2), NMI(4), PIK3CA(94), PIK3R1(7), PTK2B(6), STAT5A(1), STAT5B(5)	16206499	287	197	221	46	127	11	43	36	68	2	3.46e-05	1.000	1.000
86	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(6), GOT1(2), PAH(11), TAT(5), YARS(5), YARS2(8)	5069669	40	37	40	9	17	2	5	7	9	0	0.201	1.000	1.000
87	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(3), UGDH(5), UXS1(3)	2231739	14	13	14	5	4	2	3	3	2	0	0.770	1.000	1.000
88	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(1), EHHADH(6), HADHA(4), SDS(2)	2817763	15	15	15	8	11	1	0	0	3	0	0.918	1.000	1.000
89	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(3), B3GALT5(3), B3GNT5(8), FUT1(3), FUT2(6), FUT3(3), ST3GAL3(3), ST3GAL4(1)	4212211	32	23	32	9	22	0	7	1	2	0	0.265	1.000	1.000
90	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(13), GABARAP(3), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPHN(5), NSF(6), SRC(5), UBQLN1(5)	6922805	88	70	87	18	29	4	25	19	11	0	0.0798	1.000	1.000
91	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(6), GGPS1(1), IDI1(2), IDI2(4), SQLE(4)	2479141	17	17	17	5	7	0	6	3	1	0	0.587	1.000	1.000
92	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(50), EP300(77), LPL(4), NCOA1(25), NCOA2(12), PPARG(13), RXRA(25)	10761211	206	148	183	31	78	8	34	20	64	2	0.00273	1.000	1.000
93	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(6), ACAT1(5), ECHS1(1), HADHA(4)	3151489	19	19	19	8	11	0	3	2	3	0	0.874	1.000	1.000
94	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(6), ALDOB(3), ALDOC(2), TPI1(1)	2282528	12	12	12	9	5	1	3	2	1	0	0.979	1.000	1.000
95	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPX1(2), PRKCE(5), SOD1(4)	4593551	62	54	62	15	16	3	20	15	8	0	0.234	1.000	1.000
96	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IGF1(2), IGF1R(11), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4)	14437897	234	172	164	34	133	6	40	32	23	0	4.38e-05	1.000	1.000
97	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(17), EGFR(7), ERBB3(48), NRG1(18), UBE2D1(2)	6010906	92	79	81	19	41	7	25	11	8	0	0.112	1.000	1.000
98	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(6), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST3GAL5(5), ST6GALNAC4(2), ST8SIA1(3)	3277672	21	19	21	9	7	1	3	7	3	0	0.692	1.000	1.000
99	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(4), FOSL1(3), FOSL2(5), IFNAR1(2), IFNAR2(6), IFNB1(1), MAPK8(5), NFKB1(3), RELA(6), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	6421901	38	34	37	9	19	1	5	1	11	1	0.548	1.000	1.000
100	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(7), SRP19(1), SRP54(3), SRP68(12), SRP72(6), SRP9(1), SRPR(3)	4424152	33	30	33	9	19	1	2	5	6	0	0.547	1.000	1.000
101	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA(4), LPO(8), MPO(4), PRDX6(5), TPO(16)	4842840	43	38	43	11	19	2	14	4	4	0	0.192	1.000	1.000
102	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5)	3476319	20	20	20	6	10	1	5	4	0	0	0.479	1.000	1.000
103	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(14), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(3), APOBEC3F(1), APOBEC4(7)	4289239	33	29	33	9	23	2	6	2	0	0	0.359	1.000	1.000
104	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(7), RB1(73), RELA(6), SP1(10)	11271904	232	176	166	36	105	7	18	21	75	6	0.00294	1.000	1.000
105	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAA2(2), ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), SDS(2)	4887057	29	25	28	9	19	2	0	1	7	0	0.674	1.000	1.000
106	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(3), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(4), IL6(4)	3126878	23	20	23	9	11	1	5	4	2	0	0.680	1.000	1.000
107	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(3), CAT(9), EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16)	6839783	69	56	68	16	36	2	17	6	7	1	0.0516	1.000	1.000
108	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(4), GLUD1(6), OAT(1), PRODH(3)	3204178	20	19	19	7	12	2	3	1	2	0	0.742	1.000	1.000
109	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(3), GRB2(3), HRAS(21), IGF1R(11), IRS1(9), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(7), RAF1(4), SHC1(8), SOS1(23), YWHAH(2)	11104597	199	151	131	32	113	6	33	27	20	0	0.000627	1.000	1.000
110	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), P2RY1(3), P2RY2(1), P2RY6(2)	3479393	17	15	17	9	5	1	4	6	1	0	0.696	1.000	1.000
111	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(6), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2)	5836285	37	32	37	7	20	1	6	3	7	0	0.283	1.000	1.000
112	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(28), RANGAP1(4)	4925357	35	32	35	8	19	4	5	2	5	0	0.710	1.000	1.000
113	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL16(13), IL1A(1), IL2(1), IL5(1), IL6(4), LTA(1), TNF(4)	5783775	35	31	35	9	22	0	7	2	4	0	0.222	1.000	1.000
114	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), FADD(7), FAS(1), FASLG(1), GZMB(2), JUN(4), MAP2K4(4), MAP3K1(10), MAPK10(9), MCL1(2), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), PARP1(14), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5)	21671424	399	249	286	64	158	11	107	29	92	2	4.68e-06	1.000	1.000
115	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), CTH(5), GOT1(2), LDHB(2), LDHC(4), MPST(1)	3992401	19	19	19	9	10	2	4	1	2	0	0.894	1.000	1.000
116	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3)	8771309	81	65	80	17	40	6	12	11	12	0	0.0400	1.000	1.000
117	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3)	8771309	81	65	80	17	40	6	12	11	12	0	0.0400	1.000	1.000
118	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3)	8771309	81	65	80	17	40	6	12	11	12	0	0.0400	1.000	1.000
119	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CRK(4), CXCL12(6), CXCR4(4), GNAI1(4), GNAQ(3), GNB1(7), HRAS(21), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3C2G(11), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PTK2B(6), PXN(3), RAF1(4), RELA(6)	15949164	230	158	162	37	132	14	36	27	21	0	5.44e-05	1.000	1.000
120	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(3), CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IL6(4), IL6R(4), IL6ST(9), JAK1(9), JAK2(8), JAK3(12), JUN(4), MAP2K1(3), MAPK3(8), PTPN11(4), RAF1(4), SHC1(8), SOS1(23), SRF(4), STAT3(6)	13848961	153	115	142	29	72	5	34	18	24	0	0.0138	1.000	1.000
121	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(9), LDLR(10), MBTPS1(13), MBTPS2(7), SCAP(9), SREBF1(6), SREBF2(8)	6841875	62	55	61	17	30	1	14	4	13	0	0.187	1.000	1.000
122	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(1), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(6), PPT1(1)	4925239	29	22	27	9	21	3	1	1	3	0	0.544	1.000	1.000
123	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREBBP(50), EP300(77), NCOA3(16), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RARA(6), RXRA(25)	12026063	202	144	181	35	68	10	35	21	66	2	0.00676	1.000	1.000
124	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC3(5), RPN1(3), RPN2(5), UBE2A(2), UBE3A(10)	7496769	59	53	58	12	37	1	9	7	5	0	0.138	1.000	1.000
125	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(7), CREBBP(50), EP300(77), FADD(7), HDAC3(1), IKBKB(11), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1)	12947961	193	138	184	33	76	6	28	18	63	2	0.00450	1.000	1.000
126	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TAT(5), TPO(16)	12703476	104	78	103	24	50	3	26	9	15	1	0.0123	1.000	1.000
127	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(11), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF5(9), GSK3B(5), PPP1CA(8)	6762412	68	52	68	13	36	1	15	6	10	0	0.174	1.000	1.000
128	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), FDXR(5), SHMT1(3)	9323680	86	68	85	20	45	6	12	11	12	0	0.0620	1.000	1.000
129	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(1), JAK1(9), JAK2(8), PLA2G2A(2), PTPRU(7), REG1A(8), STAT1(13)	6688362	51	46	50	12	23	0	15	4	9	0	0.228	1.000	1.000
130	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(11), CD44(2), CSF1(4), FCGR3A(3), IL1B(3), IL6R(4), SPN(6), TGFB1(3), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFRSF8(8), TNFSF8(4)	7576664	63	47	60	15	31	0	19	4	9	0	0.0975	1.000	1.000
131	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(9), EPX(6), LPO(8), MPO(4), MTHFR(4), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16)	6743191	58	49	58	16	27	3	17	5	6	0	0.199	1.000	1.000
132	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28)	9755657	77	68	77	17	34	5	16	7	15	0	0.134	1.000	1.000
133	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(6), ADRB2(3), CFTR(18), GNAS(12), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7603732	61	49	61	14	27	3	14	10	7	0	0.172	1.000	1.000
134	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(29), CDH1(15), CREBBP(50), EP300(77), MAP2K1(3), MAP3K7(8), MAPK3(8), SKIL(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8)	14971808	224	149	216	31	79	8	32	22	79	4	0.00165	1.000	1.000
135	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(3), IARS(6), IARS2(10), ILVBL(3), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2), VARS(5), VARS2(12)	10782385	70	59	70	12	37	3	18	3	9	0	0.0409	1.000	1.000
136	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7)	7687900	50	45	50	13	21	2	11	5	11	0	0.222	1.000	1.000
137	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(3), AKT2(5), AKT3(8), BAD(3), BTK(5), CDKN2A(30), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(5), IARS(6), IGFBP1(4), INPP5D(5), PDK1(2), PIK3CA(94), PPP1R13B(7), PTEN(16), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SOS1(23), SOS2(8), TEC(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	20890972	302	181	233	45	176	13	34	34	43	2	5.13e-05	1.000	1.000
138	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(6), AKT1(3), ASAH1(4), GNAI1(4), GNB1(7), ITGAV(13), ITGB3(9), MAPK3(8), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLCB1(17), PRKCA(3), PTK2(15), RAC1(4), SMPD1(7), SMPD2(2), SPHK1(1), SRC(5)	15998412	225	164	165	40	132	12	34	29	18	0	0.000270	1.000	1.000
139	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(29), AXIN1(4), CREBBP(50), CTNNB1(15), DVL1(5), EP300(77), FZD1(4), GSK3B(5), HDAC1(4), LDB1(3), LEF1(4), PITX2(7), TRRAP(40)	19295421	247	169	233	39	100	10	43	24	68	2	0.000213	1.000	1.000
140	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(3), AKT1(3), AKT2(5), AKT3(8), ARRB1(4), ARRB2(4), ATF2(1), ATF4(3), BDNF(3), BRAF(9), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CACNA2D1(19), CACNA2D2(6), CACNA2D3(8), CACNA2D4(8), CACNB1(5), CACNB2(9), CACNB3(5), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(4), CACNG4(8), CACNG5(7), CACNG6(3), CACNG7(8), CACNG8(3), CASP3(3), CD14(3), CDC25B(2), CDC42(4), CHUK(7), CRK(4), CRKL(1), DAXX(9), DDIT3(1), DUSP1(3), DUSP10(4), DUSP14(4), DUSP16(6), DUSP2(2), DUSP4(3), DUSP5(1), DUSP6(7), DUSP7(4), DUSP8(6), DUSP9(3), ECSIT(4), EGF(17), EGFR(7), ELK1(1), ELK4(6), FAS(1), FASLG(1), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FLNA(14), FLNB(23), FLNC(18), FOS(4), GADD45A(1), GADD45G(1), GNA12(3), GNG12(2), GRB2(3), HRAS(21), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), JUN(4), JUND(2), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MAPT(10), MEF2C(5), MKNK1(6), MKNK2(3), MOS(2), MRAS(2), MYC(2), NF1(39), NFATC2(13), NFATC4(5), NFKB1(3), NFKB2(3), NLK(6), NR4A1(2), NRAS(7), NTF3(1), NTRK1(7), NTRK2(7), PAK1(4), PAK2(9), PDGFB(3), PDGFRA(16), PDGFRB(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PPM1A(6), PPM1B(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PPP5C(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTPN5(2), PTPN7(1), PTPRR(8), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(16), RASA1(8), RASA2(6), RASGRF1(12), RASGRF2(9), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KA6(11), RRAS(2), RRAS2(2), SOS1(23), SOS2(8), SRF(4), STK3(7), STK4(6), TAOK1(11), TAOK2(16), TAOK3(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF1A(5), TP53(226), TRAF2(5), TRAF6(1), ZAK(11)	164604592	1657	367	1473	520	730	59	404	179	279	6	0.341	1.000	1.000
141	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), ARHGAP5(12), BAD(3), BCAR1(6), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(2), CAV2(1), CAV3(1), CCND1(4), CCND2(1), CCND3(8), CDC42(4), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), CRK(4), CRKL(1), CTNNB1(15), DIAPH1(5), DOCK1(11), EGF(17), EGFR(7), ELK1(1), ERBB2(54), FARP2(7), FIGF(2), FLNA(14), FLNB(23), FLNC(18), FLT1(8), FN1(21), FYN(7), GRB2(3), GSK3B(5), HGF(12), HRAS(21), IBSP(4), IGF1(2), IGF1R(11), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), JUN(4), KDR(19), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), MAP2K1(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MET(19), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARVA(1), PARVB(6), PARVG(3), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PRKCA(3), PRKCG(7), PTEN(16), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(36), RHOA(19), ROCK1(8), ROCK2(15), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SPP1(2), SRC(5), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TLN1(17), TLN2(13), TNC(19), TNN(20), TNR(12), TNXB(38), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCL(4), VEGFA(7), VEGFB(3), VEGFC(6), VTN(3), VWF(21), ZYX(4)	214658828	1888	363	1758	568	922	86	436	202	242	0	0.482	1.000	1.000
142	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(7), ACTN1(7), ACTN2(10), ACTN4(13), APC(29), APC2(6), ARAF(2), ARHGEF1(8), ARHGEF12(14), ARHGEF4(5), ARHGEF6(7), ARHGEF7(9), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), ARPC5(5), BAIAP2(5), BCAR1(6), BDKRB1(4), BDKRB2(3), BRAF(9), CD14(3), CDC42(4), CFL1(1), CFL2(4), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CRK(4), CRKL(1), CSK(7), CYFIP1(8), CYFIP2(9), DIAPH1(5), DIAPH2(22), DIAPH3(7), DOCK1(11), EGF(17), EGFR(7), EZR(12), F2(3), F2R(2), FGD1(6), FGD3(4), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FN1(21), GIT1(6), GNA12(3), GNA13(12), GNG12(2), GSN(2), HRAS(21), IQGAP1(11), IQGAP2(10), IQGAP3(12), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), KRAS(14), LIMK1(6), LIMK2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MOS(2), MRAS(2), MSN(1), MYH10(24), MYH14(7), MYH9(35), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), NCKAP1(12), NCKAP1L(10), NRAS(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDGFB(3), PDGFRA(16), PDGFRB(7), PFN1(4), PFN2(1), PFN3(1), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP1R12B(10), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RDX(4), RHOA(19), ROCK1(8), ROCK2(15), RRAS(2), RRAS2(2), SCIN(1), SLC9A1(7), SOS1(23), SOS2(8), SSH1(8), SSH2(18), SSH3(17), TIAM1(17), TIAM2(18), VAV1(8), VAV2(8), VAV3(7), VCL(4), WAS(4), WASF1(5), WASF2(7), WASL(2)	159672928	1497	358	1348	434	779	60	297	175	185	1	0.0660	1.000	1.000
143	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY7(4), ADCY8(18), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), AGTR1(3), ATP2A1(9), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), ATP2B4(15), AVPR1A(4), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(4), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CCKAR(3), CCKBR(9), CD38(1), CHRM1(2), CHRM2(5), CHRM3(8), CHRM5(3), CHRNA7(2), CYSLTR2(2), DRD1(2), EDNRA(4), EDNRB(8), EGFR(7), ERBB2(54), ERBB3(48), ERBB4(11), F2R(2), GNA11(3), GNA14(3), GNA15(5), GNAL(4), GNAQ(3), GNAS(12), GRIN1(9), GRIN2A(14), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), GRPR(1), HRH1(9), HRH2(1), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), LHCGR(7), LTB4R2(3), MYLK(15), MYLK2(7), NOS1(15), NOS3(11), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), PDE1A(8), PDE1B(4), PDE1C(15), PDGFRA(16), PDGFRB(7), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PLN(2), PPID(2), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTAFR(1), PTGER3(5), PTGFR(7), PTK2B(6), RYR1(54), RYR2(83), RYR3(54), SLC25A4(2), SLC25A6(1), SLC8A1(8), SLC8A2(11), SLC8A3(6), SPHK1(1), SPHK2(11), TACR1(3), TACR2(1), TACR3(5), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(9), VDAC1(3), VDAC2(3)	155176749	1353	339	1298	580	629	71	359	134	158	2	0.997	1.000	1.000
144	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(9), ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), ATM(65), ATR(32), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDC14A(5), CDC14B(10), CDC16(4), CDC20(4), CDC23(1), CDC25A(5), CDC25B(2), CDC25C(2), CDC27(13), CDC6(9), CDC7(4), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), CHEK1(3), CHEK2(11), CREBBP(50), CUL1(19), DBF4(11), E2F1(3), E2F2(4), E2F3(5), EP300(77), ESPL1(17), FZR1(5), GADD45A(1), GADD45G(1), GSK3B(5), HDAC1(4), HDAC2(3), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), PCNA(4), PKMYT1(2), PLK1(5), PRKDC(35), PTTG1(2), RB1(73), RBL1(9), RBL2(9), RBX1(1), SFN(1), SKP1(7), SKP2(5), SMAD2(5), SMAD3(6), SMAD4(8), SMC1A(16), SMC1B(9), TFDP1(2), TGFB1(3), TGFB3(1), TP53(226), WEE1(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	78745666	1128	338	972	177	445	38	200	102	323	20	1.77e-10	1.000	1.000
145	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(29), APC2(6), AXIN1(4), AXIN2(19), BTRC(4), CACYBP(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CCND1(4), CCND2(1), CCND3(8), CER1(4), CHD8(18), CREBBP(50), CSNK1A1(6), CSNK1A1L(4), CSNK1E(3), CSNK2A1(11), CSNK2B(5), CTBP1(6), CTBP2(10), CTNNB1(15), CTNNBIP1(1), CUL1(19), CXXC4(1), DAAM1(10), DAAM2(9), DKK1(2), DKK2(5), DKK4(2), DVL1(5), DVL2(9), DVL3(4), EP300(77), FBXW11(1), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LEF1(4), LRP5(8), LRP6(15), MAP3K7(8), MAPK10(9), MAPK8(5), MAPK9(5), MMP7(1), MYC(2), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKD1(3), NKD2(1), NLK(6), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PORCN(2), PPARD(6), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRICKLE1(7), PRICKLE2(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PSEN1(8), RAC1(4), RAC2(1), RAC3(3), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RUVBL1(7), SENP2(1), SFRP1(2), SFRP2(4), SFRP4(5), SIAH1(3), SKP1(7), SMAD2(5), SMAD3(6), SMAD4(8), SOX17(3), TBL1X(5), TBL1XR1(8), TBL1Y(3), TCF7(3), TCF7L2(1), TP53(226), VANGL1(5), VANGL2(3), WIF1(6), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2)	93550978	1107	332	971	287	480	47	251	104	221	4	0.0155	1.000	1.000
146	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), AMOTL1(8), ASH1L(35), CASK(9), CDC42(4), CDK4(6), CGN(10), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTTN(10), EPB41(9), EPB41L1(8), EPB41L2(8), EPB41L3(18), EXOC3(8), EXOC4(13), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), HCLS1(5), HRAS(21), IGSF5(4), INADL(16), JAM2(1), JAM3(4), KRAS(14), LLGL1(4), LLGL2(6), MAGI1(15), MAGI2(17), MAGI3(16), MLLT4(15), MPDZ(20), MPP5(5), MRAS(2), MYH1(16), MYH10(24), MYH11(22), MYH13(21), MYH14(7), MYH15(22), MYH2(22), MYH3(19), MYH4(21), MYH6(14), MYH7(19), MYH7B(20), MYH8(17), MYH9(35), MYL2(4), MYL5(2), MYLPF(3), NRAS(7), OCLN(4), PARD3(23), PARD6A(7), PARD6B(5), PARD6G(1), PPM1J(3), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP2R3A(14), PPP2R3B(4), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PTEN(16), RAB13(2), RAB3B(5), RHOA(19), RRAS(2), RRAS2(2), SPTAN1(68), SRC(5), SYMPK(11), TJAP1(2), TJP1(9), TJP2(13), TJP3(4), VAPA(6), YES1(7), ZAK(11)	112809305	1131	328	1093	323	559	62	222	94	192	2	0.170	1.000	1.000
147	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(7), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(3), CCKBR(9), CGA(2), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CNR1(4), CNR2(6), CRHR1(4), CRHR2(3), CTSG(4), CYSLTR2(2), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2(3), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHB(1), FSHR(5), GABBR1(7), GABBR2(6), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GABRB1(7), GABRB2(7), GABRB3(10), GABRD(3), GABRE(6), GABRG1(9), GABRG2(5), GABRG3(6), GABRP(3), GABRQ(6), GABRR1(6), GABRR2(2), GALR1(3), GALR2(4), GALR3(3), GH1(3), GH2(4), GHR(6), GHRHR(5), GHSR(8), GIPR(3), GLP1R(3), GLP2R(3), GLRA1(6), GLRA2(4), GLRA3(5), GLRB(3), GNRHR(2), GPR156(7), GPR35(2), GPR50(15), GPR63(3), GPR83(3), GRIA1(16), GRIA2(7), GRIA3(6), GRIA4(23), GRID1(12), GRID2(12), GRIK1(12), GRIK2(15), GRIK3(15), GRIK4(7), GRIK5(14), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRIN3A(5), GRIN3B(2), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM6(9), GRM7(12), GRM8(8), GRPR(1), GZMA(4), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HRH4(3), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LEP(1), LEPR(8), LHB(2), LHCGR(7), LTB4R2(3), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MCHR1(3), MCHR2(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPBWR2(4), NPFFR1(2), NPFFR2(6), NPY1R(7), NPY2R(4), NPY5R(5), NR3C1(6), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), P2RY1(3), P2RY10(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(23), PRL(3), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER3(5), PTGER4(5), PTGFR(7), PTGIR(2), PTH2R(8), RXFP1(8), RXFP2(4), SCTR(4), SSTR1(3), SSTR3(4), SSTR4(6), SSTR5(1), TAAR1(3), TAAR5(2), TAAR6(3), TAAR8(4), TACR1(3), TACR2(1), TACR3(5), THRA(2), THRB(1), TRHR(9), TRPV1(3), TSHR(8), UTS2R(1), VIPR1(1), VIPR2(4)	128714603	1105	322	1094	500	454	50	326	144	130	1	0.981	1.000	1.000
148	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(9), ATM(65), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDAN1(6), CDC14A(5), CDC14B(10), CDC20(4), CDC25A(5), CDC25B(2), CDC25C(2), CDC6(9), CDC7(4), CDH1(15), CDK2(1), CDK4(6), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), DTX4(3), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), EP300(77), ESPL1(17), GADD45A(1), GSK3B(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), HDAC8(4), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MPEG1(12), MPL(7), PCNA(4), PLK1(5), PRKDC(35), PTPRA(2), PTTG1(2), RB1(73), RBL1(9), SKP2(5), SMAD4(8), TBC1D8(7), TFDP1(2), TGFB1(3), TP53(226), WEE1(10)	63548681	916	320	774	153	346	30	158	83	283	16	9.10e-09	1.000	1.000
149	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(20), ACTG1(11), CHAD(3), COL11A1(30), COL11A2(13), COL17A1(8), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), DES(2), DSC1(9), DSC2(4), DSC3(10), DSG1(12), DSG2(11), DSG3(7), DSG4(9), FN1(21), GJA1(3), GJA10(4), GJA3(3), GJA4(2), GJA5(5), GJA8(4), GJA9(6), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(4), GJD4(4), IBSP(4), INA(2), ITGA6(9), ITGB4(15), KRT1(2), KRT10(6), KRT12(4), KRT13(4), KRT14(3), KRT15(5), KRT16(5), KRT17(1), KRT18(5), KRT19(8), KRT2(4), KRT20(7), KRT23(2), KRT24(7), KRT25(2), KRT27(4), KRT28(4), KRT3(4), KRT31(2), KRT32(3), KRT33A(3), KRT33B(9), KRT34(3), KRT35(3), KRT36(5), KRT37(1), KRT38(6), KRT39(5), KRT4(4), KRT40(4), KRT5(7), KRT6A(6), KRT6B(3), KRT6C(6), KRT7(2), KRT71(6), KRT72(3), KRT73(4), KRT74(2), KRT75(6), KRT76(5), KRT77(4), KRT78(5), KRT79(6), KRT8(6), KRT82(3), KRT83(5), KRT84(10), KRT85(3), KRT9(4), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), LMNA(5), LMNB1(4), LMNB2(7), NES(20), PRPH(4), RELN(36), SPP1(2), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VIM(7), VTN(3), VWF(21)	144100947	1150	320	1128	426	553	52	301	101	142	1	1.000	1.000	1.000
150	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(12), CD36(2), CD44(2), CD47(2), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), DAG1(3), FN1(21), FNDC1(17), FNDC3A(12), GP5(1), GP6(5), GP9(3), HMMR(2), HSPG2(33), IBSP(4), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), RELN(36), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SPP1(2), SV2A(6), SV2B(6), SV2C(6), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VTN(3), VWF(21)	129159742	1018	315	1005	359	476	48	255	99	140	0	0.998	1.000	1.000
151	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(9), ABLIM1(7), ABLIM2(4), ABLIM3(2), ARHGEF12(14), CDC42(4), CDK5(3), CFL1(1), CFL2(4), CXCL12(6), CXCR4(4), DCC(26), DPYSL2(4), DPYSL5(1), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB2(6), EFNB3(4), EPHA1(4), EPHA2(20), EPHA3(20), EPHA4(2), EPHA5(23), EPHA6(14), EPHA7(12), EPHA8(10), EPHB1(14), EPHB2(10), EPHB3(12), EPHB4(7), EPHB6(11), FES(3), FYN(7), GNAI1(4), GNAI2(5), GNAI3(6), GSK3B(5), HRAS(21), ITGB1(3), KRAS(14), L1CAM(8), LIMK1(6), LIMK2(5), LRRC4C(8), MAPK3(8), MET(19), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NGEF(6), NRAS(7), NRP1(8), NTN1(5), NTN4(4), NTNG1(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLXNA1(8), PLXNA2(17), PLXNA3(7), PLXNB1(13), PLXNB2(23), PLXNB3(10), PLXNC1(9), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTK2(15), RAC1(4), RAC2(1), RAC3(3), RASA1(8), RGS3(4), RHOA(19), RND1(4), ROBO1(17), ROBO2(22), ROBO3(6), ROCK1(8), ROCK2(15), SEMA3A(11), SEMA3C(9), SEMA3D(18), SEMA3E(13), SEMA3F(6), SEMA3G(8), SEMA4A(9), SEMA4B(6), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA4G(6), SEMA5A(7), SEMA5B(16), SEMA6A(5), SEMA6B(6), SEMA6C(8), SEMA6D(12), SEMA7A(3), SLIT1(9), SLIT2(17), SLIT3(11), SRGAP1(7), SRGAP2(10), SRGAP3(7), UNC5A(5), UNC5B(10), UNC5C(17), UNC5D(10)	113686802	1019	314	992	323	437	50	287	114	129	2	0.423	1.000	1.000
152	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(4), AKT1(3), AKT2(5), AKT3(8), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CAPN1(5), CAPN2(2), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(5), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL3RA(6), IRAK1(3), IRAK2(5), IRAK3(9), IRAK4(7), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), NTRK1(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), RIPK1(7), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF1A(5), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5)	48377566	715	311	541	136	333	23	146	66	144	3	1.10e-06	1.000	1.000
153	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(65), CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG2(4), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), CREB3(5), CREB3L3(8), CREB3L4(7), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), GADD45A(1), GBA2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MNAT1(4), MYC(2), MYT1(10), NACA(14), PCNA(4), POLA2(11), POLE(27), POLE2(4), RB1(73), RBL1(9), RPA2(1), RPA3(4), TFDP1(2), TFDP2(5), TNXB(38), TP53(226), WEE1(10)	44759364	731	308	591	119	266	24	152	51	224	14	1.16e-07	1.000	1.000
154	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(9), ABL2(7), AKT1(3), AKT2(5), AKT3(8), ARAF(2), AREG(2), BAD(3), BRAF(9), BTC(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CBL(8), CBLB(13), CBLC(3), CDKN1A(38), CDKN1B(6), CRK(4), CRKL(1), EGF(17), EGFR(7), EIF4EBP1(1), ELK1(1), ERBB2(54), ERBB3(48), ERBB4(11), EREG(1), GAB1(7), GRB2(3), GSK3B(5), HBEGF(1), HRAS(21), JUN(4), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MYC(2), NCK1(2), NCK2(5), NRAS(7), NRG1(18), NRG2(3), NRG3(8), NRG4(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), RAF1(4), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SRC(5), STAT5A(1), STAT5B(5)	59691762	711	306	583	179	353	36	150	70	96	6	0.0341	1.000	1.000
155	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(5), AKT3(8), BCL2L1(4), CBL(8), CBLB(13), CBLC(3), CCND1(4), CCND2(1), CCND3(8), CISH(1), CLCF1(3), CNTF(5), CNTFR(1), CREBBP(50), CRLF2(2), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), EP300(77), EPO(2), EPOR(5), GH1(3), GH2(4), GHR(6), GRB2(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL19(2), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), IRF9(6), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), LIF(2), LIFR(9), MPL(7), MYC(2), OSM(5), OSMR(9), PIAS1(3), PIAS2(1), PIAS3(6), PIAS4(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIM1(1), PRL(3), PRLR(4), PTPN11(4), PTPN6(2), SOCS3(1), SOCS4(1), SOCS5(3), SOCS7(5), SOS1(23), SOS2(8), SPRED1(4), SPRED2(6), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), STAM(4), STAM2(6), STAT1(13), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(5), STAT6(9), TPO(16), TSLP(3), TYK2(9)	84415300	803	305	729	195	386	28	144	93	148	4	0.00255	1.000	1.000
156	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(28), ACACB(21), AKT1(3), AKT2(5), AKT3(8), ARAF(2), BAD(3), BRAF(9), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CBL(8), CBLB(13), CBLC(3), CRK(4), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(8), FASN(12), FBP1(3), FBP2(2), FLOT1(4), FLOT2(5), FOXO1(2), G6PC(2), G6PC2(2), GCK(1), GRB2(3), GSK3B(5), GYS1(12), GYS2(13), HRAS(21), IKBKB(11), INPP5D(5), INSR(10), IRS1(9), IRS2(5), IRS4(18), KRAS(14), LIPE(14), MAP2K1(3), MAP2K2(5), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MKNK1(6), MKNK2(3), NRAS(7), PCK1(9), PCK2(2), PDE3A(11), PDE3B(9), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PKLR(8), PPARGC1A(18), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R3A(18), PPP1R3B(3), PPP1R3C(4), PPP1R3D(3), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(1), PTPN1(5), PTPRF(14), PYGB(8), PYGL(4), PYGM(13), RAF1(4), RAPGEF1(6), RHEB(4), RHOQ(1), RPS6(5), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SLC2A4(4), SOCS3(1), SOCS4(1), SORBS1(10), SOS1(23), SOS2(8), SREBF1(6), TRIP10(6), TSC1(34), TSC2(11)	92696070	891	305	804	275	453	29	182	96	130	1	0.383	1.000	1.000
157	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), ANXA6(6), ARRB1(4), ARRB2(4), ATP1A4(11), ATP1B1(1), ATP1B2(5), ATP1B3(2), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1S(12), CACNB1(5), CACNB3(5), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CASQ1(7), CASQ2(5), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), GJA1(3), GJA4(2), GJA5(5), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GNA11(3), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), ITPR1(21), ITPR2(33), ITPR3(9), KCNB1(8), KCNJ3(4), KCNJ5(2), MIB1(9), NME7(3), PEA15(2), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLN(2), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SLC8A3(6), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3)	108011816	921	297	907	420	422	47	221	97	133	1	1.000	1.000	1.000
158	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(7), ATM(65), ATR(32), BAI1(5), BAX(2), BID(2), CASP3(3), CASP8(14), CASP9(6), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG1(2), CCNG2(4), CD82(3), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), CYCS(1), DDB2(8), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(5), IGF1(2), IGFBP3(1), MDM2(6), MDM4(2), PERP(2), PMAIP1(1), PPM1D(5), PTEN(16), RCHY1(2), RFWD2(6), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(3), SERPINE1(6), SESN1(10), SESN2(2), SESN3(11), SFN(1), SIAH1(3), STEAP3(3), THBS1(8), TNFRSF10B(6), TP53(226), TP53I3(4), TP73(6), TSC2(11), ZMAT3(3)	37787823	650	294	515	111	261	24	141	50	165	9	6.81e-06	1.000	1.000
159	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), ACVR1B(2), ACVR1C(3), BAIAP2(5), CDC42(4), CDH1(15), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), EGFR(7), EP300(77), ERBB2(54), FARP2(7), FER(12), FGFR1(6), FYN(7), IGF1R(11), INSR(10), IQGAP1(11), LEF1(4), LMO7(13), MAP3K7(8), MAPK3(8), MET(19), MLLT4(15), NLK(6), PARD3(23), PTPN1(5), PTPN6(2), PTPRB(17), PTPRF(14), PTPRJ(8), PTPRM(17), PVRL1(10), PVRL2(5), PVRL3(5), PVRL4(4), RAC1(4), RAC2(1), RAC3(3), RHOA(19), SMAD2(5), SMAD3(6), SMAD4(8), SNAI1(4), SNAI2(3), SORBS1(10), SRC(5), SSX2IP(3), TCF7(3), TCF7L2(1), TGFBR1(7), TGFBR2(8), TJP1(9), VCL(4), WAS(4), WASF1(5), WASF2(7), WASF3(5), WASL(2), YES1(7)	69697310	740	293	684	183	341	38	139	79	138	5	0.0256	1.000	1.000
160	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(7), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADM(3), ARRB1(4), ARRB2(4), ATF1(2), ATF2(1), ATF4(3), ATP2A2(10), ATP2A3(5), CACNB3(5), CALCA(1), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CNN1(3), CNN2(4), CORIN(7), CREB3(5), CRHR1(4), DGKZ(3), ETS2(5), FOS(4), GABPA(6), GABPB2(2), GBA2(1), GJA1(3), GNAQ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), GSTO1(2), GUCY1A3(12), IGFBP1(4), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(3), IL6(4), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), MIB1(9), MYL2(4), MYLK2(7), NFKB1(3), NOS1(15), NOS3(11), OXT(1), OXTR(1), PDE4B(7), PDE4D(4), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLCD1(6), PLCG1(12), PLCG2(6), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RLN1(2), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SP1(10), TNXB(38), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3)	99781943	853	293	839	356	403	42	198	83	125	2	0.998	1.000	1.000
161	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(5), CADM1(6), CADM3(4), CD2(2), CD22(4), CD226(5), CD274(5), CD276(1), CD28(4), CD34(3), CD4(3), CD40(5), CD40LG(2), CD58(1), CD6(3), CD80(2), CD86(6), CD8A(2), CD99(4), CDH1(15), CDH15(8), CDH2(14), CDH3(7), CDH4(18), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(11), CNTN2(9), CNTNAP1(12), CNTNAP2(25), CTLA4(1), ESAM(1), F11R(5), GLG1(9), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), ICAM1(7), ICAM2(1), ICAM3(5), ICOS(2), ICOSLG(3), ITGA4(19), ITGA6(9), ITGA8(20), ITGA9(9), ITGAL(17), ITGAM(13), ITGAV(13), ITGB1(3), ITGB2(7), ITGB7(3), ITGB8(11), JAM2(1), JAM3(4), L1CAM(8), MADCAM1(1), MAG(4), MPZ(5), MPZL1(3), NCAM1(9), NCAM2(16), NEGR1(2), NEO1(12), NFASC(11), NLGN1(11), NLGN2(3), NLGN3(6), NRCAM(16), NRXN1(25), NRXN2(11), NRXN3(10), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(19), PTPRF(14), PTPRM(17), PVR(4), PVRL1(10), PVRL2(5), PVRL3(5), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SELE(7), SELP(7), SELPLG(3), SIGLEC1(12), SPN(6), VCAM1(14), VCAN(37)	85441016	787	291	774	264	356	43	176	95	115	2	0.674	1.000	1.000
162	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(7), ACVR1B(2), ACVR2A(3), ACVR2B(2), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(3), BMPR1B(5), BMPR2(9), CCL1(3), CCL13(2), CCL14(2), CCL15(1), CCL16(1), CCL17(1), CCL2(1), CCL21(2), CCL22(2), CCL23(1), CCL25(2), CCL26(1), CCL27(1), CCL28(1), CCL3(2), CCL5(1), CCL7(3), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CD27(6), CD40(5), CD40LG(2), CD70(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF1(4), CSF1R(11), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), CX3CL1(9), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL12(6), CXCL13(2), CXCL14(2), CXCL16(1), CXCL2(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(3), CXCR4(4), CXCR6(4), EDA(6), EDA2R(1), EDAR(4), EGF(17), EGFR(7), EPO(2), EPOR(5), FAS(1), FASLG(1), FLT1(8), FLT3(10), FLT3LG(1), FLT4(10), GDF5(2), GH1(3), GH2(4), GHR(6), HGF(12), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17B(3), IL17RA(4), IL17RB(2), IL18R1(4), IL18RAP(9), IL19(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL1RAP(5), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), INHBA(3), INHBB(3), INHBC(1), INHBE(6), KDR(19), KIT(9), KITLG(5), LEP(1), LEPR(8), LIF(2), LIFR(9), LTA(1), LTB(3), LTBR(3), MET(19), MPL(7), NGFR(4), OSM(5), OSMR(9), PDGFB(3), PDGFC(5), PDGFRA(16), PDGFRB(7), PF4V1(2), PLEKHO2(5), PPBP(2), PRL(3), PRLR(4), RELT(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(3), TNFRSF14(2), TNFRSF17(2), TNFRSF18(2), TNFRSF19(3), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(5), TNFSF11(1), TNFSF13(2), TNFSF13B(5), TNFSF14(1), TNFSF18(4), TNFSF4(1), TNFSF8(4), TNFSF9(2), TPO(16), TSLP(3), VEGFA(7), VEGFB(3), VEGFC(6), XCL2(1)	102687070	814	287	809	268	374	30	184	96	128	2	0.465	1.000	1.000
163	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BID(2), BRAF(9), CASP3(3), CD244(6), CD247(1), CD48(1), FAS(1), FASLG(1), FCER1G(1), FCGR3A(3), FCGR3B(8), FYN(7), GRB2(3), GZMB(2), HCST(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-E(5), HLA-G(3), HRAS(21), ICAM1(7), ICAM2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), ITGAL(17), ITGB2(7), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRD1(1), KLRK1(2), KRAS(14), LAT(1), LCK(2), LCP2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MICA(2), MICB(3), NCR1(4), NCR2(4), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NRAS(7), PAK1(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRF1(7), PRKCA(3), PRKCG(7), PTK2B(6), PTPN11(4), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D1A(1), SH2D1B(3), SH3BP2(2), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SYK(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFSF10(5), TYROBP(1), ULBP1(2), ULBP3(2), VAV1(8), VAV2(8), VAV3(7), ZAP70(3)	65745066	649	286	568	190	330	24	138	71	85	1	0.156	1.000	1.000
164	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRB1(3), CSNK1D(3), DRD1(2), DRD2(5), EGF(17), EGFR(7), GJA1(3), GJD2(4), GNA11(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAQ(3), GNAS(12), GRB2(3), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(21), HTR2A(2), HTR2B(5), HTR2C(1), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK3(8), MAPK7(3), NPR1(8), NPR2(6), NRAS(7), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), PRKX(1), RAF1(4), SOS1(23), SOS2(8), SRC(5), TJP1(9), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4)	76853148	666	283	637	238	309	30	177	70	80	0	0.722	1.000	1.000
165	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(7), ACTN2(10), ACTN4(13), ARHGAP5(12), BCAR1(6), CD99(4), CDC42(4), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), CXCL12(6), CXCR4(4), CYBA(2), CYBB(1), ESAM(1), EZR(12), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), ITK(6), JAM2(1), JAM3(4), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MLLT4(15), MMP2(7), MMP9(6), MSN(1), MYL2(4), MYL5(2), MYLPF(3), NCF1(1), NCF2(6), NCF4(3), NOX1(4), NOX3(5), OCLN(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAC1(4), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(9), RASSF5(2), RHOA(19), RHOH(3), ROCK1(8), ROCK2(15), SIPA1(5), THY1(3), TXK(10), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCAM1(14), VCL(4)	71941691	691	281	619	181	358	32	138	81	82	0	0.00895	1.000	1.000
166	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(7), ACTN2(10), ACTN4(13), DES(2), DMD(41), MYBPC1(17), MYBPC2(8), MYBPC3(5), MYH3(19), MYH6(14), MYH7(19), MYH8(17), MYL2(4), MYOM1(17), NEB(54), TCAP(1), TMOD1(4), TNNC2(1), TNNI1(5), TNNI2(2), TNNI3(1), TNNT1(7), TNNT2(1), TNNT3(1), TPM1(3), TPM2(2), TPM3(1), TPM4(3), TTN(389), VIM(7)	78391260	679	279	674	206	326	30	154	98	65	6	0.894	1.000	1.000
167	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ASIP(1), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CREB3(5), CREB3L2(5), CREB3L3(8), CREB3L4(7), CREBBP(50), CTNNB1(15), DCT(9), DVL1(5), DVL2(9), DVL3(4), EDN1(2), EDNRB(8), EP300(77), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GSK3B(5), HRAS(21), KIT(9), KITLG(5), KRAS(14), LEF1(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MC1R(2), MITF(8), NRAS(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), POMC(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), TCF7(3), TCF7L2(1), TYR(12), TYRP1(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2)	63097402	633	276	599	222	265	29	162	68	107	2	0.610	1.000	1.000
168	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADK(3), ADSL(4), ADSS(4), ADSSL1(4), AK1(1), AK2(3), AK5(3), AK7(7), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), FHIT(4), GART(7), GDA(7), GMPR(2), GMPR2(4), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NPR1(8), NPR2(6), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT5(3), NUDT9(4), PAICS(4), PAPSS1(4), PAPSS2(2), PDE10A(8), PDE11A(19), PDE1A(8), PDE1C(15), PDE2A(2), PDE3B(9), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6H(1), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PDE9A(7), PFAS(7), PKLR(8), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PPAT(4), PRIM2(1), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), XDH(11)	94682952	719	275	707	265	366	37	155	62	97	2	0.971	1.000	1.000
169	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(9), ACTN1(7), ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGEF6(7), ARHGEF7(9), BCAR1(6), BRAF(9), CDC42(4), CDKN2A(30), CRK(4), CSE1L(12), DOCK1(11), EPHB2(10), FYN(7), GRB2(3), GRB7(1), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGB3BP(2), MAP2K4(4), MAP2K7(3), MAP3K11(5), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MRAS(2), MYLK(15), MYLK2(7), P4HB(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CA(94), PIK3CB(11), PKLR(8), PLCG1(12), PLCG2(6), PTEN(16), PTK2(15), RAF1(4), RALA(2), RHO(3), ROCK1(8), ROCK2(15), SHC1(8), SOS1(23), SOS2(8), SRC(5), TERF2IP(4), TLN1(17), TLN2(13), VASP(1), WAS(4), ZYX(4)	70782261	670	272	597	160	349	31	112	86	91	1	0.00422	1.000	1.000
170	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(9), CACNA1A(25), CRHR1(4), GNA11(3), GNA12(3), GNA13(12), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GNAZ(3), GRIA1(16), GRIA2(7), GRIA3(6), GRID2(12), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(21), IGF1(2), IGF1R(11), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), LYN(5), MAP2K1(3), MAP2K2(5), MAPK3(8), NOS1(15), NOS3(11), NPR1(8), NPR2(6), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), RAF1(4), RYR1(54)	63815252	596	271	568	211	280	24	158	65	68	1	0.744	1.000	1.000
171	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(5), AKT3(8), BCL10(3), CARD11(14), CBL(8), CBLB(13), CBLC(3), CD247(1), CD28(4), CD3E(2), CD3G(2), CD4(3), CD40LG(2), CD8A(2), CDC42(4), CDK4(6), CHUK(7), CTLA4(1), FOS(4), FYN(7), GRAP2(3), GRB2(3), HRAS(21), ICOS(2), IFNG(2), IKBKB(11), IL10(1), IL2(1), IL5(1), ITK(6), JUN(4), KRAS(14), LAT(1), LCK(2), LCP2(5), MALT1(8), MAP3K8(5), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDCD1(3), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCQ(10), PTPN6(2), PTPRC(19), RASGRP1(6), RHOA(19), SOS1(23), SOS2(8), TEC(10), TNF(4), VAV1(8), VAV2(8), VAV3(7), ZAP70(3)	58939510	633	270	548	149	335	25	127	69	77	0	0.00439	1.000	1.000
172	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(6), ADCY8(18), ARAF(2), ATF4(3), BRAF(9), CACNA1C(14), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CREBBP(50), EP300(77), GNAQ(3), GRIA1(16), GRIA2(7), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), HRAS(21), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), MAP2K1(3), MAP2K2(5), MAPK3(8), NRAS(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11)	57533505	604	270	573	198	245	32	144	73	108	2	0.543	1.000	1.000
173	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(7), BAD(3), BAK1(2), BAX(2), BCL2L1(4), BCL2L11(3), BID(2), BIRC2(3), BIRC3(3), BIRC5(2), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), GZMB(2), HELLS(5), IKBKB(11), IRF1(1), IRF2(6), IRF3(6), IRF4(3), IRF5(4), IRF6(4), IRF7(3), JUN(4), LTA(1), MAP2K4(4), MAP3K1(10), MAPK10(9), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PLEKHG5(7), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF10B(6), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFSF10(5), TP53(226), TP73(6), TRADD(2), TRAF2(5), TRAF3(2)	33184169	506	269	391	100	213	17	129	36	109	2	0.000159	1.000	1.000
174	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(5), BAK1(2), BAX(2), BFAR(7), BTK(5), CAD(16), CASP10(1), CASP3(3), CASP8(14), CD7(3), CSNK1A1(6), DAXX(9), DEDD(6), DFFA(6), DIABLO(3), EGFR(7), EPHB2(10), FADD(7), FAF1(4), HSPB1(1), IL1A(1), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MET(19), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR0B2(2), PFN1(4), PFN2(1), PTPN13(19), RALBP1(2), RIPK1(7), ROCK1(8), SMPD1(7), TNFRSF6B(1), TP53(226), TPX2(7), TRAF2(5), TUFM(3)	41985811	537	266	426	110	223	12	149	42	109	2	0.000630	1.000	1.000
175	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(2), CALML3(1), CALML6(3), CDIPT(3), CDS1(5), CDS2(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(11), ITPK1(4), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), OCRL(4), PI4KA(11), PI4KB(13), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PRKCA(3), PRKCG(7), PTEN(16), PTPMT1(3), SYNJ1(20), SYNJ2(8)	71982084	641	265	575	203	351	26	119	64	81	0	0.420	1.000	1.000
176	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(2), APOA2(5), CD36(2), CITED2(3), CPT1B(4), CREBBP(50), DUSP1(3), DUT(2), EHHADH(6), EP300(77), FABP1(2), HSD17B4(5), HSPA1A(3), JUN(4), LPL(4), MAPK3(8), ME1(5), MRPL11(2), MYC(2), NCOA1(25), NCOR1(42), NCOR2(19), NFKBIA(6), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(7), PIK3CA(94), PIK3R1(7), PPARA(1), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PTGS2(6), RB1(73), RELA(6), RXRA(25), SP1(10), SRA1(4), STAT5A(1), STAT5B(5), TNF(4)	36680787	565	263	476	99	245	20	73	54	165	8	4.14e-06	1.000	1.000
177	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(5), AKT3(8), BAD(3), BCL2L1(4), CDC42(4), CDK2(1), CDKN1B(6), CDKN2A(30), CREB3(5), CREB5(11), EBP(1), ERBB4(11), F2RL2(2), GAB1(7), GADD45A(1), GRB2(3), GSK3A(2), GSK3B(5), IGF1(2), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), MET(19), MYC(2), NOLC1(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARD3(23), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PPP1R13B(7), PREX1(15), PTEN(16), PTK2(15), PTPN1(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SLC2A4(4), SOS1(23), SOS2(8), TSC1(34), TSC2(11), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	44922071	548	263	471	113	270	19	99	54	103	3	0.000582	1.000	1.000
178	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(20), BAD(3), CABIN1(10), CALM1(2), CALM2(2), CAMK2B(5), CAMK4(4), CD3E(2), CD3G(2), CDKN1A(38), CEBPB(3), CNR1(4), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTLA4(1), EGR2(3), EGR3(3), EP300(77), FCER1A(5), FCGR3A(3), FOS(4), FOSL1(3), GATA3(8), GATA4(1), GSK3A(2), GSK3B(5), HRAS(21), ICOS(2), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL1B(3), IL2(1), IL2RA(1), IL6(4), ITK(6), JUNB(5), KPNA5(5), MAP2K7(3), MAPK14(3), MAPK8(5), MAPK9(5), MEF2A(7), MEF2B(3), MEF2D(3), MYF5(9), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB2(3), NFKBIB(6), NFKBIE(7), NPPB(1), NUP214(17), OPRD1(5), P2RX7(5), PAK1(4), PPIA(1), PPP3CB(7), PPP3CC(4), PPP3R1(1), PTPRC(19), RELA(6), SFN(1), SLA(2), SP1(10), SP3(3), TGFB1(3), TNF(4), TRAF2(5), TRPV6(5), VAV1(8), VAV2(8), VAV3(7), XPO5(10)	52836945	585	261	557	153	234	24	117	50	153	7	0.156	1.000	1.000
179	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(7), ACVR1B(2), ACVR1C(3), ACVR2A(3), ACVR2B(2), ACVRL1(5), AMHR2(2), BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BMPR1A(3), BMPR1B(5), BMPR2(9), CDKN2B(3), CHRD(8), COMP(8), CREBBP(50), CUL1(19), DCN(3), E2F4(2), E2F5(3), EP300(77), FST(4), GDF5(2), GDF6(4), ID1(7), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(3), INHBC(1), INHBE(6), LEFTY2(2), LTBP1(20), MAPK3(8), MYC(2), NODAL(3), NOG(2), PITX2(7), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), RBL1(9), RBL2(9), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RPS6KB1(4), RPS6KB2(1), SKP1(7), SMAD1(6), SMAD2(5), SMAD3(6), SMAD4(8), SMAD6(2), SMAD7(3), SMAD9(3), SMURF1(8), SMURF2(8), SP1(10), TFDP1(2), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNF(4), ZFYVE16(14), ZFYVE9(26)	57515988	565	261	544	162	239	25	123	57	117	4	0.575	1.000	1.000
180	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(1), CDC42(4), DLD(7), DUSP10(4), DUSP4(3), DUSP8(6), GAB1(7), GADD45A(1), GCK(1), IL1R1(1), JUN(4), MAP2K4(4), MAP2K5(4), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK10(9), MAPK7(3), MAPK8(5), MAPK9(5), MYEF2(5), NFATC3(14), NR2C2(7), PAPPA(15), SHC1(8), TP53(226), TRAF6(1), ZAK(11)	29209597	466	260	355	85	178	15	136	36	99	2	0.000337	1.000	1.000
181	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ATF4(3), CACNA1C(14), CACNA1D(18), CACNA1F(11), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDC42(4), CGA(2), EGFR(7), ELK1(1), FSHB(1), GNA11(3), GNAQ(3), GNAS(12), GNRH1(3), GNRHR(2), GRB2(3), HBEGF(1), HRAS(21), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), KRAS(14), LHB(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK9(5), MMP14(4), MMP2(7), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLD1(9), PLD2(3), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCD(8), PRKX(1), PTK2B(6), RAF1(4), SOS1(23), SOS2(8), SRC(5)	73445578	596	259	568	264	272	25	151	65	83	0	1.000	1.000	1.000
182	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), AKAP1(8), AKAP10(6), AKAP11(15), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(29), AKAP7(3), AKAP8(3), AKAP9(49), ARHGEF1(8), CALM1(2), CALM2(2), CHMP1B(3), GNA11(3), GNA12(3), GNA13(12), GNA14(3), GNA15(5), GNAI2(5), GNAI3(6), GNAL(4), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB5(2), GNG12(2), GNG3(3), GNG4(5), GNG5(1), GNGT2(1), HRAS(21), IL18BP(2), ITPR1(21), KCNJ3(4), KRAS(14), NRAS(7), PALM2(3), PDE1A(8), PDE1B(4), PDE1C(15), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PLCB3(11), PPP3CA(7), PPP3CC(4), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKD3(13), RHOA(19), RRAS(2), SLC9A1(7), USP5(3)	67981034	622	256	584	200	309	31	129	68	84	1	0.652	1.000	1.000
183	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(7), ACVR1B(2), ACVRL1(5), AKT1(3), AURKB(2), BMPR1A(3), BMPR2(9), BUB1(18), CDIPT(3), CDKL1(2), CDKL2(5), CDS1(5), CDS2(3), CLK1(7), CLK2(10), CLK4(3), COL4A3BP(8), CSNK2A1(11), CSNK2B(5), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MAP3K10(2), MOS(2), NEK1(5), NEK3(4), OCRL(4), PAK4(1), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PIM2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6), PLK3(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKG1(10), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KB1(4), TGFBR1(7), VRK1(3)	65148191	621	256	557	190	328	34	101	76	80	2	0.447	1.000	1.000
184	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(5), AKT3(8), BAD(3), CASP9(6), CDC42(4), HRAS(21), KDR(19), KRAS(14), MAP2K1(3), MAP2K2(5), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPKAPK2(1), MAPKAPK3(3), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NOS3(11), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCA(3), PRKCG(7), PTGS2(6), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D2A(6), SHC2(3), SPHK1(1), SPHK2(11), SRC(5), VEGFA(7)	41681082	478	251	401	112	237	22	102	53	64	0	0.00218	1.000	1.000
185	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(8), BCAR1(6), CAPN1(5), CAPN10(2), CAPN11(2), CAPN2(2), CAPN3(7), CAPN5(4), CAPN6(3), CAPN7(4), CAPN9(6), CAV2(1), CAV3(1), CDC42(4), CRK(4), CSK(7), DOCK1(11), FYN(7), GIT2(6), GRB2(3), ILK(3), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAPK10(9), MAPK12(2), MAPK4(5), MAPK6(4), MAPK7(3), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PDPK1(2), PIK3R2(4), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(8), ROCK2(15), SDCCAG8(8), SEPP1(4), SHC1(8), SHC3(1), SORBS1(10), SOS1(23), SRC(5), TLN1(17), TNS1(20), VASP(1), VAV2(8), VAV3(7), VCL(4), ZYX(4)	77266507	605	249	601	205	295	27	130	80	73	0	0.820	1.000	1.000
186	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CCRL2(4), CHML(6), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CNR2(6), CX3CR1(4), CXCR3(3), CXCR4(4), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GPR17(3), GPR173(2), GPR174(4), GPR27(1), GPR35(2), GPR37(6), GPR37L1(5), GPR4(4), GPR50(15), GPR6(5), GPR63(3), GPR83(3), GPR85(4), GPR87(3), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LHCGR(7), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(5), OPRK1(4), OPRL1(2), OR10A5(2), OR11A1(4), OR12D3(1), OR1C1(2), OR1F1(2), OR1Q1(2), OR2H1(3), OR5V1(5), OR7A5(6), OR7C1(6), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(2), P2RY12(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), RGR(3), RHO(3), RRH(4), SSTR1(3), SSTR3(4), SSTR4(6), SUCNR1(3), TRHR(9)	70712238	548	246	543	302	225	28	166	71	58	0	0.994	1.000	1.000
187	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(5), AKT3(8), CASP8(14), CCL3(2), CCL5(1), CD14(3), CD40(5), CD80(2), CD86(6), CHUK(7), CXCL10(2), CXCL11(1), CXCL9(3), FADD(7), FOS(4), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IKBKB(11), IKBKE(6), IL12A(1), IL12B(3), IL1B(3), IL6(4), IRAK1(3), IRAK4(7), IRF3(6), IRF5(4), IRF7(3), JUN(4), LBP(2), LY96(1), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K7(8), MAP3K8(5), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), RAC1(4), RELA(6), RIPK1(7), SPP1(2), STAT1(13), TBK1(7), TICAM1(9), TLR1(3), TLR2(3), TLR3(10), TLR4(6), TLR5(11), TLR6(6), TLR7(9), TLR8(9), TLR9(12), TNF(4), TOLLIP(3), TRAF3(2), TRAF6(1)	51991140	513	245	449	132	293	23	79	52	65	1	0.0119	1.000	1.000
188	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(5), AKT3(8), BCL10(3), BLNK(8), BTK(5), CARD11(14), CD19(4), CD22(4), CD72(2), CD79A(4), CD79B(2), CD81(2), CHUK(7), CR2(17), FCGR2B(2), FOS(4), GSK3B(5), HRAS(21), IKBKB(11), INPP5D(5), JUN(4), KRAS(14), LILRB3(12), LYN(5), MALT1(8), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RASGRP3(5), SYK(8), VAV1(8), VAV2(8), VAV3(7)	43152671	486	245	407	110	241	24	98	54	69	0	0.00171	1.000	1.000
189	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(19), AMY2A(3), AMY2B(9), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENPP1(7), ENPP3(6), ENTPD7(5), EP400(23), ERCC2(39), ERCC3(7), G6PC(2), G6PC2(2), GAA(5), GANC(7), GBA(4), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), IFIH1(8), LYZL1(1), MGAM(16), MOV10L1(7), NUDT5(3), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SI(23), SKIV2L2(9), SMARCA2(24), SMARCA5(4), TREH(5), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UXS1(3)	71874261	584	244	560	188	274	34	117	87	72	0	0.841	1.000	1.000
190	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADK(3), ADSL(4), ADSS(4), AK1(1), AK2(3), AK5(3), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), FHIT(4), GART(7), GDA(7), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NPR1(8), NPR2(6), NT5C(1), NT5E(6), PAICS(4), PAPSS1(4), PAPSS2(2), PDE1A(8), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6B(5), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(7), PFAS(7), PKLR(8), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), PPAT(4), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RRM1(4), RRM2(4)	74370900	566	242	557	212	269	31	129	54	81	2	0.960	1.000	1.000
191	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(35), ASH2L(1), CARM1(6), CTCFL(5), DOT1L(21), EED(5), EHMT1(8), EHMT2(12), EZH1(6), EZH2(6), FBXO11(6), HCFC1(4), HSF4(4), JMJD4(4), JMJD6(4), KDM6A(107), MEN1(3), NSD1(23), OGT(5), PAXIP1(8), PPP1CA(8), PPP1CB(4), PPP1CC(2), PRDM2(18), PRDM7(5), PRDM9(13), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), RBBP5(4), SATB1(6), SETD1A(9), SETD2(32), SETD7(3), SETD8(3), SETDB1(14), SETDB2(3), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(1), SUV39H2(1), SUV420H1(20), SUV420H2(2), SUZ12(9), WHSC1(18), WHSC1L1(16)	68945194	499	241	477	133	235	14	63	52	129	6	0.881	1.000	1.000
192	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(13), ABCA10(9), ABCA12(31), ABCA13(45), ABCA2(11), ABCA3(8), ABCA4(15), ABCA5(10), ABCA6(20), ABCA7(11), ABCA8(19), ABCA9(17), ABCB1(16), ABCB10(6), ABCB11(4), ABCB4(11), ABCB5(24), ABCB6(6), ABCB7(5), ABCB8(10), ABCB9(1), ABCC1(10), ABCC10(10), ABCC11(14), ABCC12(14), ABCC2(12), ABCC3(16), ABCC4(11), ABCC5(25), ABCC6(6), ABCC8(10), ABCC9(16), ABCD1(5), ABCD2(9), ABCD3(9), ABCD4(2), ABCG1(5), ABCG2(10), ABCG4(7), ABCG5(4), ABCG8(3), CFTR(18), TAP1(3), TAP2(2)	68236069	513	241	509	166	241	29	99	60	82	2	0.113	1.000	1.000
193	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(5), AKT3(8), BTK(5), FCER1A(5), FCER1G(1), FYN(7), GAB2(8), GRB2(3), HRAS(21), IL5(1), INPP5D(5), KRAS(14), LAT(1), LCP2(5), LYN(5), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MS4A2(6), NRAS(7), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PRKCA(3), PRKCD(8), PRKCE(5), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SOS1(23), SOS2(8), SYK(8), TNF(4), VAV1(8), VAV2(8), VAV3(7)	41767716	451	235	374	123	228	14	98	63	48	0	0.0954	1.000	1.000
194	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(4), ATF1(2), BRAF(9), CAMP(1), CREB3(5), CREB5(11), CREBBP(50), CRKL(1), DAG1(3), EGR1(7), EGR2(3), EGR3(3), EGR4(5), ELK1(1), FRS2(10), GNAQ(3), JUN(4), MAP1B(19), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), NTRK1(7), OPN1LW(5), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(7), PTPN11(4), RPS6KA3(9), SHC1(8), SRC(5), TERF2IP(4), TH(2)	29577944	358	232	294	83	187	16	68	38	48	1	0.0152	1.000	1.000
195	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(11), APAF1(7), ARHGDIB(1), BAG4(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), GSN(2), LMNA(5), LMNB1(4), LMNB2(7), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK8(5), MDM2(6), NFKB1(3), NFKBIA(6), NUMA1(16), PAK2(9), PRKCD(8), PRKDC(35), PSEN1(8), PSEN2(2), PTK2(15), RASA1(8), RB1(73), RELA(6), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	39982194	438	231	428	116	205	18	55	20	134	6	0.446	1.000	1.000
196	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(5), AKT3(8), BRD4(15), CAP1(12), CBL(8), CDC42(4), CDKN2A(30), F2RL2(2), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), LNPEP(7), MAPK3(8), PARD3(23), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PTEN(16), PTPN1(5), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SERPINB6(4), SFN(1), SHC1(8), SLC2A4(4), SORBS1(10), SOS1(23), SOS2(8), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	34604802	439	230	367	92	247	16	62	51	60	3	0.00251	1.000	1.000
197	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG6(3), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(5), B3GNT6(1), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT7(1), C1GALT1(4), C1GALT1C1(3), CHPF(4), CHST1(2), CHST11(2), CHST12(3), CHST14(3), CHST2(1), CHST4(3), CHST6(1), CHST7(2), CHSY1(9), DDOST(1), DPAGT1(6), EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), FUT11(2), FUT8(7), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GANAB(16), GCNT1(5), GCNT3(3), GCNT4(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), NDST1(2), NDST2(2), NDST3(7), NDST4(13), OGT(5), RPN1(3), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(8), STT3B(5), UST(4), WBSCR17(9), XYLT1(6), XYLT2(6)	63726999	430	227	425	183	215	22	86	57	49	1	0.994	1.000	1.000
198	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5E(1), INPPL1(11), IPMK(2), ISYNA1(2), ITPK1(4), ITPKA(4), ITPKB(5), MINPP1(5), MIOX(2), OCRL(4), PI4KA(11), PI4KB(13), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PTEN(16), PTPMT1(3), SYNJ1(20), SYNJ2(8)	43092798	408	225	344	113	237	12	75	46	38	0	0.0790	1.000	1.000
199	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(8), CDC40(2), CLK2(10), CLK3(2), CLK4(3), COL2A1(14), CPSF1(9), CPSF2(3), CPSF3(8), CPSF4(3), CSTF1(2), CSTF2(6), CSTF2T(5), CSTF3(4), DDIT3(1), DDX1(8), DDX20(10), DHX15(12), DHX16(9), DHX38(6), DHX8(12), DHX9(21), DICER1(19), DNAJC8(1), FUS(9), GIPC1(2), LSM2(2), LSM7(1), METTL3(22), NCBP1(2), NCBP2(1), NONO(4), NUDT21(1), NXF1(10), PABPN1(4), PAPOLA(10), PHF5A(2), POLR2A(13), PPM1G(10), PRPF18(6), PRPF3(10), PRPF4(5), PRPF4B(8), PRPF8(8), PSKH1(3), PTBP1(2), PTBP2(8), RBM17(11), RBM5(12), RNGTT(4), RNMT(4), RNPS1(2), SF3A1(6), SF3A3(7), SF3B1(24), SF3B2(5), SF3B4(3), SF3B5(2), SNRPA(6), SNRPA1(3), SNRPB(8), SNRPB2(3), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNRPE(2), SNRPG(2), SNRPN(5), SPOP(6), SRPK1(2), SRPK2(6), SRRM1(5), SUPT5H(11), U2AF1(9), U2AF2(4), XRN2(7)	61451614	483	225	467	140	259	29	83	43	68	1	0.895	1.000	1.000
200	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CD22(4), CD81(2), CR2(17), CSK(7), DAG1(3), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), INPP5D(5), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP4K1(8), MAPK3(8), NFATC1(14), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PTPRC(19), RAF1(4), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8)	42972563	428	225	367	124	236	22	73	49	48	0	0.172	1.000	1.000
201	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGAP1(1), ARHGAP4(3), ARHGEF11(11), BTK(5), CDC42(4), CFL1(1), CFL2(4), GDI1(3), GDI2(5), INPPL1(11), ITPR1(21), ITPR2(33), ITPR3(9), LIMK1(6), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3CG(10), PIK3R1(7), PITX2(7), PPP1R13B(7), PTEN(16), RACGAP1(6), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), SAG(2), WASF1(5), WASL(2)	40775820	393	222	329	99	224	14	56	50	49	0	0.0351	1.000	1.000
202	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK1G(4), CAMK4(4), CREBBP(50), CSNK1A1(6), EDN1(2), ELSPBP1(3), F2(3), FKBP1A(1), GATA4(1), GSK3B(5), HAND1(4), HAND2(2), HRAS(21), IGF1(2), LIF(2), MAP2K1(3), MAPK14(3), MAPK3(8), MAPK8(5), MEF2C(5), MYH2(22), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKX2-5(5), NPPA(2), PIK3CA(94), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAF1(4), RPS6KB1(4), SYT1(6)	29510952	387	220	316	83	181	22	77	42	63	2	0.00271	1.000	1.000
203	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(9), CHUK(7), DAXX(9), ELK1(1), FOS(4), GRB2(3), HRAS(21), IKBKB(11), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP3K9(11), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAP4K5(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK4(5), MAPK6(4), MAPK7(3), MAPK8(5), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(6), PAK1(4), PAK2(9), RAC1(4), RAF1(4), RELA(6), RIPK1(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KB1(4), RPS6KB2(1), SHC1(8), SP1(10), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5)	54792449	472	219	460	159	232	20	89	47	81	3	0.915	1.000	1.000
204	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), APH1A(3), CREBBP(50), CTBP1(6), CTBP2(10), DLL1(9), DLL3(4), DLL4(5), DTX1(5), DTX2(6), DTX3(4), DTX3L(9), DTX4(3), DVL1(5), DVL2(9), DVL3(4), EP300(77), HDAC1(4), HDAC2(3), HES1(12), JAG1(13), JAG2(1), LFNG(2), MAML1(3), MAML2(6), MAML3(5), NCOR2(19), NCSTN(10), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), NUMB(3), NUMBL(1), PSEN1(8), PSEN2(2), RBPJ(3), RBPJL(6), RFNG(1), SNW1(11)	39655372	383	216	373	105	152	16	84	35	92	4	0.208	1.000	1.000
205	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(15), BDKRB1(4), BDKRB2(3), C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C3AR1(4), C4BPA(8), C4BPB(3), C5(9), C5AR1(3), C6(9), C7(4), C8A(7), C8B(3), C8G(2), C9(8), CD46(8), CD55(2), CFB(10), CFH(13), CFI(3), CPB2(5), CR1(14), CR2(17), F10(6), F11(10), F12(3), F13A1(8), F13B(9), F2(3), F2R(2), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), KNG1(5), MASP1(12), MASP2(5), MBL2(1), PLAT(6), PLAU(2), PLAUR(7), PLG(4), PROC(2), PROS1(14), SERPINA1(1), SERPINA5(5), SERPINC1(7), SERPIND1(6), SERPINE1(6), SERPING1(3), THBD(4), VWF(21)	52489557	426	215	420	145	190	23	109	51	53	0	0.901	1.000	1.000
206	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(5), AKT3(8), BRAF(9), CAB39(3), DDIT4(2), EIF4B(4), EIF4EBP1(1), FIGF(2), HIF1A(6), IGF1(2), MAPK3(8), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PRKAA1(9), PRKAA2(7), RHEB(4), RICTOR(19), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), TSC1(34), TSC2(11), ULK1(9), ULK2(9), ULK3(1), VEGFA(7), VEGFB(3), VEGFC(6)	30655982	362	211	298	83	196	14	53	41	57	1	0.0298	1.000	1.000
207	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(21), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ADIPOR1(8), ADIPOR2(1), AGRP(2), AKT1(3), AKT2(5), AKT3(8), CAMKK1(3), CAMKK2(5), CD36(2), CHUK(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), G6PC(2), G6PC2(2), IKBKB(11), IRS1(9), IRS2(5), IRS4(18), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), MAPK10(9), MAPK8(5), MAPK9(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NPY(2), PCK1(9), PCK2(2), POMC(1), PPARA(1), PPARGC1A(18), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3), PRKCQ(10), PTPN11(4), RELA(6), RXRA(25), RXRB(4), RXRG(8), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TYK2(9)	48088678	396	211	380	124	192	21	82	38	63	0	0.353	1.000	1.000
208	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(5), AKT3(8), BCR(3), BTK(5), CD19(4), CDKN2A(30), DAPP1(2), FLOT1(4), FLOT2(5), GAB1(7), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(94), PITX2(7), PLCG2(6), PPP1R13B(7), PREX1(15), PTEN(16), PTPRC(19), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SAG(2), SYK(8), TEC(10), VAV1(8)	31925957	373	209	303	84	210	14	54	41	53	1	0.00252	1.000	1.000
209	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(6), CD14(3), CD19(4), CD1A(7), CD1B(3), CD1C(2), CD1D(14), CD1E(13), CD2(2), CD22(4), CD33(6), CD34(3), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(3), CD44(2), CD5(3), CD55(2), CD7(3), CD8A(2), CD9(3), CR1(14), CR2(17), CSF1(4), CSF1R(11), CSF2RA(7), CSF3(1), CSF3R(5), DNTT(11), EPO(2), EPOR(5), FCGR1A(2), FLT3(10), FLT3LG(1), GP5(1), GP9(3), GYPA(5), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL2RA(1), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL7(1), IL7R(7), IL9R(3), ITGA1(7), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGAM(13), ITGB3(9), KIT(9), KITLG(5), MME(13), MS4A1(5), TFRC(9), THPO(6), TNF(4), TPO(16)	47265011	406	208	403	129	161	21	107	57	60	0	0.487	1.000	1.000
210	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(2), CD3E(2), CD3G(2), ELK1(1), FOS(4), FYN(7), GRB2(3), HRAS(21), JUN(4), LAT(1), LCK(2), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PIK3CA(94), PIK3R1(7), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), PTPN7(1), RAC1(4), RAF1(4), RASA1(8), RELA(6), SHC1(8), SOS1(23), SYT1(6), VAV1(8), ZAP70(3)	27835098	341	203	271	77	186	16	65	35	39	0	0.0281	1.000	1.000
211	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(4), CRKL(1), DOCK1(11), ELK1(1), FOS(4), GAB1(7), GRB2(3), HGF(12), HRAS(21), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP4K1(8), MAPK3(8), MAPK8(5), MET(19), PAK1(4), PIK3CA(94), PIK3R1(7), PTEN(16), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAF1(4), RAP1A(1), RAP1B(2), RASA1(8), SOS1(23), SRC(5), STAT3(6)	25525835	328	202	255	51	181	13	53	39	42	0	2.66e-05	1.000	1.000
212	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(5), CALM1(2), CALM2(2), ELK1(1), FCER1A(5), FCER1G(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PAK2(9), PIK3CA(94), PIK3R1(7), PLA2G4A(1), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8)	25068407	330	201	260	64	177	16	59	40	38	0	0.00243	1.000	1.000
213	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(29), AR(5), ASAH1(4), BRAF(9), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(3), EGFR(7), GNA11(3), GNA15(5), GNAI1(4), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), MAPK10(9), MAPK14(3), PHKA2(8), PIK3CA(94), PIK3CD(7), PIK3R1(7), PITX2(7), PTX3(6), RAF1(4), SRC(5)	30973378	311	197	249	87	182	11	42	41	35	0	0.158	1.000	1.000
214	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(11), EGF(17), EGFR(7), ELK1(1), FOS(4), GRB2(3), HRAS(21), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1)	21866273	290	193	219	51	160	10	53	31	36	0	0.000396	1.000	1.000
215	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(4), ACADL(2), ACADM(1), ACOX1(7), ACOX2(9), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ANGPTL4(6), APOA1(2), APOA2(5), APOA5(4), APOC3(1), AQP7(7), CD36(2), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP27A1(9), CYP4A11(5), CYP4A22(7), CYP7A1(10), CYP8B1(5), DBI(2), EHHADH(6), FABP1(2), FABP2(1), FABP5(1), FABP6(1), FADS2(2), GK(2), GK2(6), HMGCS2(7), ILK(3), LPL(4), ME1(5), MMP1(3), NR1H3(4), PCK1(9), PCK2(2), PDPK1(2), PLTP(7), PPARA(1), PPARD(6), PPARG(13), RXRA(25), RXRB(4), RXRG(8), SCD(2), SCP2(4), SLC27A1(6), SLC27A2(10), SLC27A4(2), SLC27A5(9), SLC27A6(6), SORBS1(10), UBC(9), UCP1(4)	37986717	324	193	302	109	158	17	80	24	45	0	0.545	1.000	1.000
216	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1)	20366460	282	191	211	49	153	9	52	31	37	0	0.000249	1.000	1.000
217	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CFLAR(2), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAF1(4), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), PTPN13(19), RB1(73), RIPK2(5), SPTAN1(68)	23432912	314	188	303	73	129	9	33	15	121	7	0.401	1.000	1.000
218	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(29), AXIN1(4), CCND1(4), CCND2(1), CCND3(8), CSNK1E(3), CTNNB1(15), DVL1(5), DVL2(9), DVL3(4), FBXW2(5), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LDLR(10), MAPK10(9), MAPK9(5), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(6), PPP2R5E(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), RAC1(4), RHOA(19), SFRP4(5), TCF7(3), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1)	34801725	318	188	304	105	173	17	55	26	47	0	0.539	1.000	1.000
219	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(4), CASP2(2), CASP3(3), CASP8(14), CRADD(1), DFFA(6), DFFB(1), FADD(7), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MADD(12), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), RB1(73), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5)	22382147	310	186	298	63	132	11	27	16	118	6	0.0430	1.000	1.000
220	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(23), CARM1(6), CCND1(4), CREBBP(50), EP300(77), ERCC3(7), ESR1(5), GRIP1(12), GTF2A1(3), GTF2E1(7), GTF2F1(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), MEF2C(5), NCOR2(19), NR0B1(4), NRIP1(7), PELP1(5), POLR2A(13), SRA1(4), TBP(2)	26423386	286	184	275	71	123	11	52	29	69	2	0.129	1.000	1.000
221	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CSK(7), DAG1(3), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), LYN(5), MAP2K1(3), MAP2K2(5), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PI3(1), PIK3CA(94), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), RAF1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8)	30626932	308	184	247	73	176	10	53	41	28	0	0.0313	1.000	1.000
222	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(14), ADAM17(7), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), CASP3(3), CCL5(1), CDC42(4), CHUK(7), CSK(7), CXCL1(1), EGFR(7), F11R(5), GIT1(6), HBEGF(1), IGSF5(4), IKBKB(11), JAM2(1), JAM3(4), JUN(4), LYN(5), MAP2K4(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK8(5), MAPK9(5), MET(19), NFKB1(3), NFKB2(3), NFKBIA(6), NOD1(6), PAK1(4), PLCG1(12), PLCG2(6), PTPN11(4), PTPRZ1(20), RAC1(4), RELA(6), SRC(5), TCIRG1(6), TJP1(9)	40872207	330	182	325	87	174	13	68	27	48	0	0.0956	1.000	1.000
223	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(4), EIF4A2(11), EIF4B(4), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), FKBP1A(1), MKNK1(6), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4), TSC1(34), TSC2(11)	16056976	263	181	198	45	132	11	38	26	55	1	0.00503	1.000	1.000
224	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(9), CPEB1(8), EGFR(7), ERBB2(54), ERBB4(11), ETS1(5), ETS2(5), ETV6(12), ETV7(4), FMN2(26), GRB2(3), KRAS(14), MAP2K1(3), MAPK3(8), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), PIWIL1(12), PIWIL2(8), PIWIL3(6), PIWIL4(8), RAF1(4), SOS1(23), SOS2(8), SPIRE1(2), SPIRE2(9)	30169663	303	180	261	84	146	19	69	33	34	2	0.375	1.000	1.000
225	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BAD(3), BCL2L1(4), CBL(8), CFLAR(2), CRKL(1), E2F1(3), FOS(4), GRB2(3), HRAS(21), IL2RA(1), IL2RB(2), IL2RG(5), IRS1(9), JAK1(9), JAK3(12), MAPK3(8), MYC(2), NMI(4), PIK3CA(94), PIK3R1(7), PPIA(1), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(8), SOCS3(1), SOS1(23), STAT5A(1), STAT5B(5), SYK(8)	20983934	262	180	193	67	135	10	48	31	37	1	0.0992	1.000	1.000
226	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(5), ALG6(3), CCKBR(9), CCR3(3), CCR5(6), CELSR1(20), CELSR2(18), CELSR3(29), CHRM2(5), CHRM3(8), CIDEB(2), CXCR3(3), DRD4(1), EDNRA(4), EMR2(6), EMR3(4), F2R(2), FSHR(5), GHRHR(5), GNRHR(2), GPR116(10), GPR132(4), GPR133(12), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(2), GPR61(7), GPR84(2), GPR88(3), GRM1(22), GRPR(1), HRH4(3), LGR6(8), LPHN2(23), LPHN3(21), LTB4R2(3), NTSR1(2), OR2M4(3), P2RY13(3), PTGFR(7), SMO(8), TAAR5(2), TSHR(8), VN1R1(2)	38569589	305	179	298	129	127	14	88	38	37	1	0.658	1.000	1.000
227	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(3), DGKA(9), GCA(1), ITGA9(9), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAPK3(8), NR1I3(4), PAK1(4), PDE3A(11), PDE3B(9), PI3(1), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(7), PSME1(2), RIPK3(6), RPS4X(4), SGCB(1), VASP(1)	28205598	278	179	216	86	163	14	41	29	31	0	0.430	1.000	1.000
228	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PRIM2(1), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), TK1(3), TK2(1), TXNRD1(6), TXNRD2(1), TYMS(3), UCK1(3), UMPS(4), UPB1(4), UPP2(3), UPRT(5)	47018508	327	178	324	128	173	20	53	37	43	1	0.985	1.000	1.000
229	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(11), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MPL(7), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), THPO(6)	17521128	259	178	188	43	152	10	38	27	32	0	0.000347	1.000	1.000
230	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF1(1), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), ELAVL1(7), FLT1(8), FLT4(10), HIF1A(6), HRAS(21), KDR(19), NOS3(11), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PXN(3), SHC1(8), VHL(2)	19756305	276	178	208	55	155	12	43	29	37	0	0.00202	1.000	1.000
231	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(1), CHN1(3), LIMK1(6), MAP3K1(10), MYL2(4), MYLK(15), NCF2(6), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLD1(9), PPP1R12B(10), RAC1(4), RALBP1(2), RPS6KB1(4), TRIO(36), VAV1(8), WASF1(5)	20347679	254	177	194	63	149	9	35	28	32	1	0.134	1.000	1.000
232	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6)	30660327	287	176	274	81	155	12	59	25	35	1	0.339	1.000	1.000
233	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6)	30660327	287	176	274	81	155	12	59	25	35	1	0.339	1.000	1.000
234	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6)	25917403	276	176	215	76	163	9	45	31	28	0	0.167	1.000	1.000
235	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(5), AKT3(8), BAD(3), GRB2(3), GSK3A(2), GSK3B(5), IL4R(6), IRS1(9), IRS2(5), JAK1(9), JAK3(12), MAP4K1(8), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PPP1R13B(7), RAF1(4), SHC1(8), SOS1(23), SOS2(8), STAT6(9)	21257169	255	175	195	56	146	7	39	36	27	0	0.0186	1.000	1.000
236	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(5), ALPL(4), ALPP(3), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENTPD7(5), EP400(23), ERCC2(39), ERCC3(7), FPGS(4), GCH1(2), GGH(3), IFIH1(8), MOV10L1(7), NUDT5(3), QDPR(3), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SKIV2L2(9), SMARCA2(24), SMARCA5(4)	36425321	311	172	292	99	152	13	65	49	32	0	0.698	1.000	1.000
237	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(12), DIAPH1(5), FYN(7), GSN(2), HRAS(21), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), MYL2(4), MYLK(15), PFN1(4), PIK3CA(94), PIK3R1(7), PTK2(15), PXN(3), RAF1(4), ROCK1(8), SHC1(8), SRC(5), TLN1(17)	21777703	252	170	185	43	137	9	47	33	26	0	0.000867	1.000	1.000
238	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(6), GRB2(3), HRAS(21), INSR(10), IRS1(9), JAK2(8), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTPN6(2), RAF1(4), RPS6KA1(5), SHC1(8), SLC2A4(4), SOS1(23), SRF(4), STAT5A(1), STAT5B(5)	19321316	243	170	175	58	140	6	43	29	25	0	0.0297	1.000	1.000
239	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), INSR(10), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SLC2A4(4), SOS1(23), SRF(4)	14807904	235	170	165	42	138	6	38	31	22	0	0.00103	1.000	1.000
240	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(6), AKT1(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), GNAS(12), GRB2(3), HRAS(21), MAPK14(3), MAPK3(8), PIK3CA(94), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAC1(4), RPS6KA1(5), RPS6KA5(9), SOS1(23)	16966243	242	168	174	52	143	6	43	28	22	0	0.0155	1.000	1.000
241	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), AFMID(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CARM1(6), CAT(9), CYP1A1(2), CYP1A2(4), CYP1B1(3), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADH(5), HADHA(4), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(1), LCMT1(2), LCMT2(12), LNX1(4), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), NFX1(8), OGDH(21), OGDHL(10), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), TDO2(3), TPH1(3), TPH2(4), WARS(5), WARS2(2), WBSCR22(7)	35180634	249	168	241	77	130	10	43	26	40	0	0.374	1.000	1.000
242	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), GHR(6), IRS1(9), MAPK14(3), MAPK3(8), MKNK1(6), PABPC1(7), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PRKCA(3), PTEN(16), RPS6KB1(4)	16448621	242	167	181	48	134	11	35	29	32	1	0.0511	1.000	1.000
243	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(8), CD28(4), CSK(7), CTLA4(1), DAG1(3), EPHB2(10), FBXW7(38), GRAP2(3), GRB2(3), ITK(6), ITPKA(4), ITPKB(5), LAT(1), LCK(2), LCP2(5), NCK1(2), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLCG1(12), PTPRC(19), RAF1(4), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), SOS1(23), SOS2(8), VAV1(8), ZAP70(3)	32312362	271	166	259	80	132	8	63	29	39	0	0.513	1.000	1.000
244	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(18), ATP4A(5), ATP4B(2), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5E(1), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), COX10(4), COX15(4), COX17(2), COX4I2(1), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX7B2(3), COX8A(1), CYC1(7), LHPP(2), NDUFA1(1), NDUFA10(5), NDUFA12(1), NDUFA13(3), NDUFA5(1), NDUFA6(2), NDUFA7(2), NDUFA8(4), NDUFA9(4), NDUFAB1(2), NDUFB10(2), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFB9(3), NDUFS1(5), NDUFS2(3), NDUFS3(4), NDUFS4(3), NDUFS6(1), NDUFS7(3), NDUFS8(1), NDUFV1(4), NDUFV2(6), NDUFV3(4), PPA1(1), PPA2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(4), UQCRFS1(3), UQCRH(2)	32357592	295	165	289	91	148	13	59	32	43	0	0.355	1.000	1.000
245	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(3), CRKL(1), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MYC(2), PIK3CA(94), PIK3R1(7), RAF1(4), SOS1(23), STAT1(13), STAT5A(1), STAT5B(5)	16384918	226	163	155	44	131	7	33	25	30	0	0.0105	1.000	1.000
246	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(10), CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), HDAC5(6), IGF1(2), IGF1R(11), INSR(10), MAP2K6(1), MAPK14(3), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), NFATC1(14), NFATC2(13), PIK3CA(94), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYT1(6), YWHAH(2)	20104042	235	163	176	57	134	14	35	26	26	0	0.0275	1.000	1.000
247	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(2), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), CYP1A1(2), CYP1A2(4), CYP1B1(3), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2F1(4), CYP2S1(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHDH(3), EPHX1(5), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), MGST1(1), MGST2(1), MGST3(1), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2)	33419411	250	162	249	91	120	14	49	30	37	0	0.743	1.000	1.000
248	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(7), ADCY6(15), ADCY8(18), CACNA1A(25), CACNA1B(20), GNAS(12), GNAT3(2), GNB1(7), GNB3(5), GNG3(3), GRM4(9), ITPR3(9), KCNB1(8), PDE1A(8), PLCB2(6), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), SCNN1A(12), SCNN1B(6), SCNN1G(5), TAS1R1(2), TAS1R2(7), TAS1R3(20), TAS2R1(1), TAS2R13(2), TAS2R14(1), TAS2R16(4), TAS2R3(3), TAS2R39(3), TAS2R4(1), TAS2R40(2), TAS2R41(3), TAS2R43(1), TAS2R46(3), TAS2R5(1), TAS2R50(3), TAS2R60(5), TAS2R7(1), TAS2R8(1), TAS2R9(6), TRPM5(6)	32728290	262	161	249	119	141	16	60	23	22	0	0.762	1.000	1.000
249	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(5), AKT3(8), CISH(1), GRB2(3), IARS(6), IL13RA1(2), IL2RG(5), IL4R(6), INPP5D(5), JAK1(9), JAK2(8), JAK3(12), NR0B2(2), PI3(1), PIK3CA(94), PPP1R13B(7), RPS6KB1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT6(9), TYK2(9)	21390961	245	161	185	52	146	7	36	33	22	1	0.0108	1.000	1.000
250	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(45), B3GALT4(6), CDR1(4), DGKI(9), FAU(2), IL6ST(9), MRPL19(2), PIGK(4), RPL10(3), RPL11(2), RPL13(3), RPL15(3), RPL17(1), RPL19(2), RPL23(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL3L(3), RPL4(5), RPL41(1), RPL5(3), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS12(3), RPS13(2), RPS15(1), RPS16(4), RPS18(6), RPS19(1), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS27A(1), RPS29(1), RPS3(1), RPS3A(1), RPS4X(4), RPS4Y1(1), RPS5(1), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), RPS7(2), RPS8(2), RPS9(3), RPSA(4), SLC36A2(1), TBC1D10C(5), TSPAN9(2), UBA52(7), UBC(9)	30355677	262	160	258	100	129	20	55	26	31	1	0.924	1.000	1.000
251	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(5), AKT3(8), ASAH1(4), BRAF(9), DAG1(3), DRD2(5), EGFR(7), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PI3(1), PIK3CB(11), PITX2(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), RAF1(4), RGS20(3), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT3(6), TERF2IP(4)	34007869	262	160	257	93	136	9	54	33	30	0	0.791	1.000	1.000
252	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BTRC(4), CSNK1A1(6), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(6), CSNK1G3(3), FBXW11(1), GLI1(10), GLI2(16), GLI3(19), GSK3B(5), HHIP(10), IHH(3), LRP2(46), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), PTCH1(19), PTCH2(5), RAB23(2), SHH(6), SMO(8), STK36(13), SUFU(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2), ZIC2(7)	35144072	278	159	275	113	120	13	77	22	46	0	0.980	1.000	1.000
253	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(19), AMY2A(3), AMY2B(9), ENPP1(7), ENPP3(6), G6PC(2), GAA(5), GANAB(16), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), MGAM(16), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RNPC3(1), SI(23), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UXS1(3)	33041540	262	156	260	96	118	17	58	32	37	0	0.940	1.000	1.000
254	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(29), AXIN1(4), CCND1(4), CD14(3), CTNNB1(15), DVL1(5), FZD1(4), GJA1(3), GNAI1(4), GSK3B(5), IRAK1(3), LBP(2), LEF1(4), LY96(1), MYD88(2), NFKB1(3), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), RELA(6), TLR4(6), TOLLIP(3)	17815899	214	155	150	41	133	6	28	20	27	0	0.0165	1.000	1.000
255	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(7), DAXX(9), EGF(17), EGFR(7), ETS1(5), ETS2(5), FOS(4), HOXA7(5), HRAS(21), IKBKB(11), JUN(4), MAP2K1(3), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), NFKB1(3), NFKBIA(6), PPP2CA(2), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), RAF1(4), RELA(6), RIPK1(7), SP1(10), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRAF2(5)	28517290	253	154	242	94	120	14	58	17	44	0	0.909	1.000	1.000
256	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(2), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(10), KDR(19), NOS3(11), PDE2A(2), PDE3A(11), PDE3B(9), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKG1(10), PRKG2(8), RYR2(83), SLC7A1(8), SYT1(6), TNNI1(5)	23210929	230	154	229	92	95	13	56	33	32	1	0.968	1.000	1.000
257	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(12), AR(5), ESR1(5), ESR2(4), ESRRA(2), HNF4A(5), NPM1(1), NR0B1(4), NR1D1(3), NR1D2(10), NR1H2(6), NR1H3(4), NR1I2(5), NR1I3(4), NR2C2(7), NR2E1(1), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(6), NR5A1(1), NR5A2(6), PGR(8), PPARA(1), PPARD(6), PPARG(13), RARA(6), RARB(9), RARG(21), ROR1(6), RORA(6), RORC(7), RXRA(25), RXRB(4), RXRG(8), THRA(2), THRB(1), VDR(2)	24214692	233	153	214	81	123	12	51	20	27	0	0.640	1.000	1.000
258	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(3), GORASP1(2), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK5(3), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PIK3CA(94), PIK3CD(7), PIK3R1(7), SYT1(6), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1)	19379493	221	153	161	47	133	13	33	23	19	0	0.00527	1.000	1.000
259	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(36), EEF1A2(3), EEF1B2(2), EEF1D(2), EEF1G(4), EEF2(5), EEF2K(7), EIF2AK1(5), EIF2AK2(7), EIF2AK3(12), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(17), EIF4G3(27), EIF5(9), EIF5A(5), EIF5B(11), ETF1(2), GSPT2(6), PABPC1(7), PABPC3(8), PAIP1(11), SLC35A4(3)	25401472	250	153	247	55	126	12	47	28	37	0	0.128	1.000	1.000
260	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), CARM1(6), COMT(3), DBH(4), DCT(9), DDC(8), ECH1(8), ESCO1(3), ESCO2(3), FAH(3), GOT1(2), GSTZ1(2), HEMK1(1), HGD(4), HPD(4), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), MIF(1), NAT6(1), PNPLA3(4), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SH3GLB1(1), TAT(5), TH(2), TPO(16), TYR(12), TYRP1(2), WBSCR22(7)	34515087	228	150	224	64	105	6	56	26	35	0	0.191	1.000	1.000
261	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(9), CDC7(4), CDK2(1), CDT1(3), DIAPH2(22), GMNN(1), MCM10(15), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), NACA(14), PCNA(4), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), RFC1(9), RFC2(5), RFC3(1), RFC4(10), RFC5(5), RPA2(1), RPA3(4), RPA4(1), RPS27A(1), UBA52(7), UBC(9)	29496490	222	149	213	63	128	10	35	22	26	1	0.349	1.000	1.000
262	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(5), ARSD(7), ARSE(2), CARM1(6), CYP11B1(6), CYP11B2(13), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(1), HSD17B12(3), HSD17B2(6), HSD17B3(1), HSD17B7(3), HSD17B8(4), HSD3B1(5), HSD3B2(5), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), SULT2B1(2), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), WBSCR22(7)	29200143	224	149	219	64	111	12	48	31	22	0	0.195	1.000	1.000
263	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASS(11), ACAT1(5), ACAT2(1), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(23), OGDH(21), OGDHL(10), PIPOX(4), PLOD1(3), PLOD2(5), PLOD3(5), RDH12(2), RDH13(1), SETD1A(9), SETD7(3), SETDB1(14), SHMT1(3), SHMT2(2), SPCS3(1), SUV39H1(1), SUV39H2(1), TMLHE(2)	33573987	232	149	226	114	129	9	41	20	33	0	1.000	1.000	1.000
264	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CHPT1(6), CRLS1(1), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(3), ETNK1(4), ETNK2(1), GNPAT(4), GPAM(5), GPD1(6), GPD1L(3), GPD2(10), LCAT(3), LYPLA1(2), LYPLA2(2), NAT6(1), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(7), PTDSS2(1), SH3GLB1(1)	37665706	247	149	246	91	118	15	52	24	38	0	0.893	1.000	1.000
265	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AKR1A1(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CEL(8), DAK(4), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), GK(2), GK2(6), GLA(3), GLB1(5), GPAM(5), LCT(16), LIPA(3), LIPC(6), LIPF(6), LIPG(4), LPL(4), MGLL(3), PNLIP(5), PNLIPRP1(8), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1)	33796651	255	148	253	90	120	14	54	27	40	0	0.619	1.000	1.000
266	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), BTRC(4), CDC16(4), CDC20(4), CDC23(1), CDC27(13), CUL1(19), CUL2(13), CUL3(9), FBXW11(1), FBXW7(38), FZR1(5), ITCH(12), RBX1(1), SKP1(7), SKP2(5), SMURF1(8), SMURF2(8), TCEB1(1), TCEB2(1), UBA1(1), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E1(1), UBE2E2(1), UBE2E3(1), VHL(2), WWP1(5), WWP2(5)	23333351	238	148	220	43	118	7	50	18	44	1	0.0183	1.000	1.000
267	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), AGTR2(4), ATP8A1(12), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CX3CR1(4), CXCR3(3), CXCR4(4), CXCR6(4), EDNRA(4), EDNRB(8), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GNRHR(2), GRPR(1), LHCGR(7), MC1R(2), MC3R(4), MC4R(3), MC5R(3), NMBR(6), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), SSTR1(3), SSTR3(4), SSTR4(6), TAC4(1), TACR1(3), TACR2(1), TACR3(5), TRHR(9), TSHR(8)	30531920	240	148	239	129	98	6	73	35	28	0	0.974	1.000	1.000
268	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CAT(9), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADHA(4), KMO(1), KYNU(1), MAOA(4), MAOB(2), SDS(2), TDO2(3), TPH1(3), WARS(5), WARS2(2)	32067281	228	148	225	84	111	10	46	27	34	0	0.687	1.000	1.000
269	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(7), ACSS2(3), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), G6PC2(2), GALM(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGAM4(4), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1)	33826358	219	147	217	98	99	11	50	23	36	0	0.979	1.000	1.000
270	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(7), CREBBP(50), DUSP1(3), EP300(77), IKBKB(11), IL1B(3), MAP2K3(6), MAP2K6(1), MAP3K7(8), MAPK11(5), MAPK14(3), MYD88(2), NFKB1(3), NFKBIA(6), NR3C1(6), RELA(6), TGFBR1(7), TGFBR2(8), TLR2(3), TNF(4)	17198705	219	146	211	43	82	9	32	19	74	3	0.0338	1.000	1.000
271	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(8), BTK(5), CALM1(2), CALM2(2), CD79A(4), CD79B(2), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8)	22254545	230	145	219	60	103	12	53	25	37	0	0.266	1.000	1.000
272	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(29), AXIN1(4), BTRC(4), CCND1(4), CREBBP(50), CSNK1A1(6), CSNK1D(3), CSNK2A1(11), CTBP1(6), CTNNB1(15), DVL1(5), FZD1(4), GSK3B(5), HDAC1(4), MAP3K7(8), MYC(2), NLK(6), PPARD(6), PPP2CA(2), TLE1(7), WIF1(6)	16992324	187	145	179	48	85	7	33	17	44	1	0.408	1.000	1.000
273	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(65), BMPR1B(5), CCND2(1), CDK4(6), CDKN1B(6), CEBPB(3), DAZL(3), DMC1(2), EGR1(7), ESR2(4), FSHR(5), GJA4(2), INHA(3), LHCGR(7), MLH1(9), NCOR1(42), NR5A1(1), NRIP1(7), PGR(8), PRLR(4), PTGER2(7), SMPD1(7), VDR(2), ZP2(8)	20364106	214	143	211	51	90	8	41	26	48	1	0.186	1.000	1.000
274	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(6), ARHGEF1(8), F2(3), F2R(2), F2RL3(2), GNA12(3), GNA13(12), GNAI1(4), GNAQ(3), GNB1(7), MAP3K7(8), PIK3CA(94), PIK3R1(7), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2B(6), ROCK1(8)	15005558	203	143	137	40	131	8	22	26	16	0	0.00648	1.000	1.000
275	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(3), APC(29), ASAH1(4), CAMP(1), CAV3(1), DAG1(3), DLG4(6), EPHB2(10), GNAI1(4), GNAQ(3), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PITX2(7), PTX3(6), RAC1(4), RHO(3), RYR1(54)	26624248	213	143	209	76	110	10	40	19	34	0	0.639	1.000	1.000
276	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(7), BAD(3), BAX(2), BCL2A1(1), BCL2L1(4), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CD40(5), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKE(6), LTA(1), MCL1(2), NFKB1(3), NFKBIA(6), NGFR(4), NR3C1(6), NTRK1(7), PTPN13(19), RIPK1(7), TFG(11), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TRAF3(2), TRAF6(1)	25113586	194	141	189	68	109	7	36	11	31	0	0.919	1.000	1.000
277	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), F10(6), F11(10), F12(3), F2(3), F2R(2), F5(24), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), PROC(2), PROS1(14), SERPINC1(7), SERPING1(3)	25660356	195	141	192	62	101	11	45	19	19	0	0.958	1.000	1.000
278	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ITPA(1), NME1(1), NME2(3), NT5C(1), NT5E(6), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), RRM1(4), RRM2(4), TK1(3), TK2(1), TXNRD1(6), TYMS(3), UCK1(3), UMPS(4), UNG(1), UPB1(4)	33291369	231	141	230	95	115	13	37	31	34	1	0.983	1.000	1.000
279	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), ELK1(1), FPR1(3), GNA15(5), GNB1(7), HRAS(21), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NCF1(1), NCF2(6), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PAK1(4), PIK3C2G(11), PLCB1(17), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAC1(4), RAF1(4), RELA(6), SYT1(6)	22140035	218	140	209	63	99	15	49	21	34	0	0.508	1.000	1.000
280	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CLC(2), CPT1B(4), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), ETNK1(4), GNPAT(4), GPD1(6), GPD2(10), LCAT(3), LGALS13(3), LYPLA1(2), LYPLA2(2), PAFAH1B1(2), PAFAH2(4), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB2(6), PLCG1(12), PLCG2(6), PPAP2A(5), PPAP2B(3), PPAP2C(1)	28674293	228	139	227	80	109	10	49	20	40	0	0.565	1.000	1.000
281	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDK5(3), F2(3), FYN(7), GNA11(3), GNAI1(4), GNB1(7), GRB2(3), HRAS(21), JAK2(8), MAP2K1(3), MAP2K2(5), MAPK14(3), MAPK3(8), MAPK8(5), MAPT(10), MYLK(15), PLCG1(12), PRKCA(3), PTK2B(6), RAF1(4), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), SYT1(6)	24219076	220	138	209	84	104	10	49	24	33	0	0.943	1.000	1.000
282	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(3), B3GALT4(6), B3GALT5(3), B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALNT1(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT6(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGZ(3), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2), UGCG(3)	28060482	203	138	200	81	100	4	47	27	25	0	0.692	1.000	1.000
283	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(28), ACACB(21), ACAT1(5), ACAT2(1), ACOT12(6), ACSS1(7), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PCK2(2), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8)	27167995	186	137	183	70	97	6	38	19	26	0	0.844	1.000	1.000
284	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(11), ACTG2(2), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(4), CFL1(1), CFL2(4), FLNA(14), FLNC(18), FSCN1(5), FSCN2(3), FSCN3(3), GDI1(3), GDI2(5), LIMK1(6), MYH2(22), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PFN1(4), PFN2(1), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), VASP(1), WASF1(5), WASL(2)	27858435	212	137	210	70	97	8	54	25	28	0	0.564	1.000	1.000
285	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(5), AKT3(8), ANKRD6(4), APC(29), AXIN1(4), AXIN2(19), CER1(4), CSNK1A1(6), CTNNB1(15), DACT1(6), DKK1(2), DKK2(5), DKK3(5), DKK4(2), DVL1(5), FSTL1(4), GSK3A(2), GSK3B(5), LRP1(36), MVP(11), NKD1(3), NKD2(1), PSEN1(8), PTPRA(2), SENP2(1), SFRP1(2), WIF1(6)	23332724	203	137	198	49	106	6	41	18	31	1	0.0897	1.000	1.000
286	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1)	28427706	199	136	196	80	89	9	48	21	32	0	0.903	1.000	1.000
287	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AKR1A1(2), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), CEL(8), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), GK(2), GLA(3), GLB1(5), LCT(16), LIPC(6), LIPF(6), LIPG(4), LPL(4), PNLIP(5), PNLIPRP1(8), PPAP2A(5), PPAP2B(3), PPAP2C(1)	27691993	226	136	223	77	108	9	48	24	37	0	0.512	1.000	1.000
288	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1)	28427706	199	136	196	80	89	9	48	21	32	0	0.903	1.000	1.000
289	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG5(3), ALG6(3), ALG8(2), ALG9(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DHDDS(7), DOLPP1(1), DPAGT1(6), DPM1(3), FUT8(7), GANAB(16), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), RFT1(4), RPN1(3), RPN2(5), ST6GAL1(4), STT3B(5)	24433056	193	134	192	68	98	9	32	30	24	0	0.699	1.000	1.000
290	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(5), AKT3(8), ARHGEF11(11), CDC42(4), DLG4(6), GNA13(12), LPA(11), MAP2K4(4), MAP3K1(10), MAP3K5(14), MAPK8(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PI3(1), PIK3CB(11), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RDX(4), ROCK1(8), ROCK2(15), SERPINA4(2), SRF(4)	28584013	206	134	199	60	107	14	32	22	31	0	0.601	1.000	1.000
291	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(7), ACTN2(10), BCAR1(6), BCR(3), CAPN1(5), CAPNS2(1), CRKL(1), CSK(7), FYN(7), GRB2(3), HRAS(21), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MAPK8(5), PPP1R12B(10), PTK2(15), PXN(3), RAF1(4), RAP1A(1), ROCK1(8), SHC1(8), SOS1(23), SRC(5), TLN1(17), VCL(4), ZYX(4)	27325846	212	132	201	63	101	10	53	20	28	0	0.466	1.000	1.000
292	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(4), CARS(5), CARS2(7), DARS(3), DARS2(10), EARS2(3), EPRS(12), FARS2(1), FARSA(2), FARSB(6), GARS(6), HARS(6), HARS2(1), IARS(6), IARS2(10), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), MTFMT(2), NARS(4), NARS2(7), PARS2(4), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(6), TARS(9), TARS2(14), VARS(5), VARS2(12), WARS(5), WARS2(2), YARS(5), YARS2(8)	31619530	225	131	222	54	128	15	36	14	32	0	0.0603	1.000	1.000
293	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(4), CANX(6), CD4(3), CD74(2), CD8A(2), CIITA(9), CTSB(6), CTSS(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), HSP90AA1(27), HSP90AB1(11), HSPA5(11), IFI30(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(1), LTA(1), NFYA(2), NFYB(1), NFYC(1), PDIA3(6), PSME1(2), RFX5(6), RFXANK(1), RFXAP(2), TAP1(3), TAP2(2), TAPBP(4)	26881897	211	130	203	77	100	11	40	20	40	0	0.775	1.000	1.000
294	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(4), DAXX(9), DDIT3(1), ELK1(1), GRB2(3), HMGN1(2), HRAS(21), HSPB1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MYC(2), PLA2G4A(1), RAC1(4), RIPK1(7), RPS6KA5(9), SHC1(8), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5)	21222612	188	130	179	59	91	9	44	12	31	1	0.756	1.000	1.000
295	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(7), APC(29), ATF2(1), AXIN1(4), BMP10(3), BMP2(1), BMP4(1), BMP5(6), BMP7(4), BMPR1A(3), BMPR2(9), CHRD(8), CTNNB1(15), DVL1(5), FZD1(4), GATA4(1), GSK3B(5), MAP3K7(8), MEF2C(5), MYL2(4), NKX2-5(5), NOG(2), NPPA(2), NPPB(1), RFC1(9), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10)	21144259	171	128	165	47	92	7	27	13	31	1	0.542	1.000	1.000
296	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(7), BID(2), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), GAS2(3), LMNA(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), SPTAN1(68), TNFRSF10A(5), TNFRSF10B(6), TNFRSF25(3), TNFSF10(5), TRADD(2), TRAF2(5)	19334317	193	128	191	58	111	8	22	7	45	0	0.694	1.000	1.000
297	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLG(8), POLG2(6), POLH(10), POLI(5), POLK(13), POLL(1), POLM(9), POLQ(28), PRIM2(1), REV1(8), REV3L(30), RFC5(5)	23539553	195	128	194	41	99	12	32	22	30	0	0.115	1.000	1.000
298	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(6), F11(10), F12(3), F13B(9), F2(3), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), LPA(11), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6), VWF(21)	20485546	170	127	167	48	85	8	39	20	18	0	0.430	1.000	1.000
299	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACADVL(2), ACAT1(5), ACAT2(1), ACOX1(7), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP4A11(5), CYP4A22(7), ECHS1(1), EHHADH(6), GCDH(6), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5)	28516176	175	127	173	64	90	8	31	13	33	0	0.769	1.000	1.000
300	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(8), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), AMDHD1(4), AOC2(5), AOC3(6), ASPA(2), CARM1(6), CNDP1(4), DDC(8), FTCD(4), HAL(7), HARS(6), HARS2(1), HDC(6), HEMK1(1), HNMT(3), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), PRPS1(3), PRPS2(1), UROC1(8), WBSCR22(7)	22963508	178	127	174	52	80	7	41	19	31	0	0.167	1.000	1.000
301	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F1(5), GTF2F2(2), GTF2H1(4), GTF2H3(5), GTF2H4(1), GTF2I(16), GTF2IRD1(9), STON1(13), TAF1(10), TAF10(1), TAF12(2), TAF13(2), TAF1L(21), TAF2(10), TAF4(6), TAF4B(6), TAF5(4), TAF5L(3), TAF6(8), TAF6L(6), TAF7(3), TAF7L(6), TAF9(7), TAF9B(2), TBPL1(2)	21011536	170	126	166	51	83	9	32	19	27	0	0.823	1.000	1.000
302	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), ATP7A(7), ATP7B(9), COX10(4), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX8A(1), NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6), PPA2(2), SDHA(9), SDHB(2), SHMT1(3), UQCRB(1), UQCRC1(2), UQCRFS1(3), UQCRH(2)	22214490	198	126	192	53	106	8	39	20	25	0	0.133	1.000	1.000
303	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(5), AZIN1(5), BTG1(3), CBX3(1), CEBPB(3), CLDN5(3), CLOCK(8), CRY1(3), CRY2(4), DAZAP2(5), DNAJA1(4), EIF4G2(10), ETV6(12), GFRA1(4), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(5), NCKAP1(12), NCOA4(6), NR1D2(10), PER1(6), PER2(6), PIGF(4), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(5), SF3A3(7), SUMO3(2), TOB1(5), TUBB3(5), UGP2(9), VAPA(6), ZFR(5)	21198935	193	124	186	58	99	11	33	18	32	0	0.808	1.000	1.000
304	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(2), AKR1B10(1), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), GNMT(3), HSD3B7(2), MAOA(4), MAOB(2), PEMT(1), PHGDH(3), PIPOX(4), PISD(3), PSAT1(6), PSPH(7), RDH12(2), RDH13(1), SARDH(4), SARS(5), SARS2(6), SDS(2), SHMT1(3), SHMT2(2), TARS(9), TARS2(14)	24615860	172	124	169	66	85	9	31	15	32	0	0.803	1.000	1.000
305	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(3), BLNK(8), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK3(8), MAPK8IP3(11), PAPPA(15), RAC1(4), RPS6KA1(5), RPS6KA3(9), SHC1(8), SOS1(23), SYK(8), VAV1(8), VAV2(8), VAV3(7)	18512847	177	124	166	50	83	3	47	21	23	0	0.372	1.000	1.000
306	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(7), ELK1(1), GNAS(12), GNB1(7), GRB2(3), HRAS(21), IGF1R(11), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), MKNK1(6), MKNK2(3), MYC(2), NGFR(4), PDGFRA(16), PPP2CA(2), PTPRR(8), RAF1(4), RPS6KA1(5), RPS6KA5(9), SHC1(8), SOS1(23), SRC(5), STAT3(6)	19270645	183	123	173	55	83	7	50	23	20	0	0.506	1.000	1.000
307	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(6), CALM1(2), CALM2(2), ELK1(1), FOS(4), GNAI1(4), GNAQ(3), GNAS(12), GNB1(7), HRAS(21), JUN(4), MAP2K1(3), MAPK3(8), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAF1(4), RPS6KA3(9), SYT1(6)	20306863	197	123	186	51	81	15	50	20	31	0	0.201	1.000	1.000
308	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(1), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), FUK(9), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), KHK(1), LHPP(2), MPI(7), MTMR1(8), MTMR2(6), MTMR6(8), PFKFB1(5), PFKFB2(3), PFKFB3(8), PFKL(2), PFKM(5), PFKP(4), PGM2(3), PMM1(6), PMM2(2), RDH12(2), RDH13(1), SORD(1), TPI1(1), TSTA3(2)	21450419	165	123	162	67	85	5	32	21	22	0	0.836	1.000	1.000
309	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(4), ACAA2(2), ACADM(1), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOX1(8), AUH(2), BCAT1(4), BCAT2(3), BCKDHA(4), BCKDHB(1), DBT(6), DLD(7), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HADHB(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), OXCT2(2), PCCA(4), PCCB(4)	25068080	173	123	170	54	99	8	20	19	27	0	0.678	1.000	1.000
310	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH4A1(4), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), GOT1(2), MAOA(4), MAOB(2), NOS1(15), NOS3(11), OAT(1), ODC1(4), OTC(2), P4HA1(8), P4HA3(3), P4HB(6), PYCR1(3), RARS(6), SMS(1)	25549625	173	122	168	57	94	4	30	21	23	1	0.441	1.000	1.000
311	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(3), ATF2(1), CALM1(2), CALM2(2), EGFR(7), ELK1(1), GNAQ(3), GRB2(3), HRAS(21), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PAK1(4), PRKCA(3), PTK2(15), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6)	19422997	181	122	170	49	78	12	41	21	29	0	0.378	1.000	1.000
312	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(1), ARHGAP4(3), ARHGAP5(12), ARHGAP6(10), ARHGEF1(8), ARHGEF11(11), ARHGEF5(6), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), BAIAP2(5), CFL1(1), DIAPH1(5), GSN(2), LIMK1(6), MYL2(4), MYLK(15), OPHN1(8), PFN1(4), PIP5K1A(8), PIP5K1B(3), PPP1R12B(10), ROCK1(8), SRC(5), TLN1(17), VCL(4)	26229374	176	122	174	55	88	6	38	22	22	0	0.614	1.000	1.000
313	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), ATP6V0C(3), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CPT1B(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), MAOA(4), MAOB(2), PEMT(1), PISD(3), PLCB2(6), PLCG1(12), PLCG2(6), PSPH(7), SARDH(4), SARS(5), SHMT1(3), SHMT2(2), TARS(9)	24201048	159	120	156	59	78	7	33	12	29	0	0.717	1.000	1.000
314	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(12), ALAS2(5), BLVRA(5), BLVRB(1), COX10(4), COX15(4), CP(5), CPOX(5), EARS2(3), EPRS(12), FECH(3), FTH1(8), FTMT(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), MMAB(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UROD(4), UROS(4)	24518901	173	119	171	57	83	7	25	25	33	0	0.795	1.000	1.000
315	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(28), ACAT1(5), ACAT2(1), ADH5(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8)	21467689	155	117	152	57	83	3	32	15	22	0	0.838	1.000	1.000
316	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(11), ACTG2(2), ADCY3(5), ADCY9(8), AK1(1), ARF3(1), ARF4(1), ARF5(2), ARF6(1), ARL4D(1), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), ERO1L(4), GNAS(12), PDIA4(5), PLCG1(12), PLCG2(6), PRKCA(3), SEC61A1(5), SEC61A2(7), TRIM23(5)	21561162	166	116	166	58	86	11	29	19	21	0	0.598	1.000	1.000
317	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(6), ALDOB(3), ALDOC(2), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(3), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGK1(2), PKLR(8), TNFAIP1(2), TPI1(1)	24702421	162	115	160	75	79	5	42	16	20	0	0.970	1.000	1.000
318	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(6), ALDH4A1(4), CAD(16), CPS1(13), EARS2(3), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GFPT2(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), GMPS(5), GNPNAT1(3), GOT1(2), GPT(2), GPT2(1), GSR(2), GSS(7), NADSYN1(6), NAGK(5), PPAT(4), QARS(6)	22982504	160	115	157	59	81	11	34	16	18	0	0.819	1.000	1.000
319	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(2), ALOX12B(3), ALOX15(5), ALOX15B(3), ALOX5(4), CBR1(2), CBR3(1), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP2U1(2), CYP4A11(5), CYP4A22(7), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), LTA4H(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3)	22520009	151	115	151	70	64	9	40	16	22	0	0.921	1.000	1.000
320	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(4), ARSD(7), ARSE(2), ASAH1(4), B4GALT6(2), CERK(2), DEGS1(3), ENPP7(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(3), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(7), SMPD2(2), SMPD3(5), SMPD4(9), SPHK1(1), SPHK2(11), SPTLC1(4), SPTLC2(5), UGCG(3), UGT8(6)	20576642	156	115	156	54	69	5	46	18	18	0	0.493	1.000	1.000
321	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM1(2), CALM2(2), CRKL(1), GNAQ(3), GRB2(3), HRAS(21), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), PAK1(4), PLCG1(12), PRKCA(3), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6)	16554880	161	115	150	47	73	7	40	16	25	0	0.511	1.000	1.000
322	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ACSM1(2), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BDH2(3), DDHD1(11), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADH(5), HADHA(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(3), L2HGDH(4), OXCT1(4), OXCT2(2), PDHA1(5), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(5), RDH12(2), RDH13(1)	23540402	155	114	154	63	83	10	24	19	19	0	0.939	1.000	1.000
323	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(13), AASS(11), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ATP6V0C(3), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(5), SDS(2), SHMT1(3), SHMT2(2), TMLHE(2)	21430958	157	114	156	73	84	7	30	15	21	0	0.995	1.000	1.000
324	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(5), AKT3(8), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PIK3CB(11), PITX2(7), PLD1(9), PLD2(3), PLD3(5), VN1R1(2)	26038876	172	114	168	67	93	8	31	15	25	0	0.863	1.000	1.000
325	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(10), CALM1(2), CALM2(2), CAPN2(2), CAPNS2(1), EP300(77), HDAC1(4), HDAC2(3), MEF2D(3), NFATC1(14), NFATC2(13), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SYT1(6)	14201552	158	113	154	39	59	14	23	20	41	1	0.311	1.000	1.000
326	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(17), EGFR(7), GRB2(3), HRAS(21), MAP2K1(3), MAPK3(8), PTPRB(17), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), SRC(5)	14534008	148	112	139	35	69	6	40	15	18	0	0.166	1.000	1.000
327	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(3), BRAF(9), CREB3(5), CREB5(11), DUSP4(3), DUSP6(7), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(3), MAP2K2(5), MAP3K8(5), MAPK3(8), MKNK1(6), MKNK2(3), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), SHC1(8), SOS1(23), SOS2(8), TRAF3(2)	17148106	156	110	154	45	79	5	28	19	25	0	0.614	1.000	1.000
328	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(28), ACACB(21), ACADM(1), ACAT1(5), ACAT2(1), ACSS1(7), ACSS2(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SUCLA2(2), SUCLG1(2), SUCLG2(3)	23121877	144	108	143	49	74	6	22	19	23	0	0.711	1.000	1.000
329	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), PON1(6)	17021974	150	107	145	63	74	10	35	13	18	0	0.724	1.000	1.000
330	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(2), ARG2(3), ASL(7), ASS1(2), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), EPRS(12), GATM(3), GLUD1(6), GLUD2(10), GOT1(2), LAP3(4), NOS1(15), NOS3(11), OAT(1), OTC(2), P4HA1(8), P4HA3(3), PARS2(4), PRODH(3), PYCR1(3), PYCR2(1), PYCRL(3), RARS(6), RARS2(6)	20764080	154	107	147	47	92	7	26	12	16	1	0.417	1.000	1.000
331	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(4), ABAT(4), ACY3(8), ADSL(4), ADSS(4), ADSSL1(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), ASRGL1(3), ASS1(2), CAD(16), CRAT(10), DARS(3), DARS2(10), DDO(1), DLAT(6), DLD(7), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), NARS2(7), PC(10), PDHA1(5), PDHA2(6), PDHB(2)	21969274	157	106	155	56	87	9	31	12	18	0	0.763	1.000	1.000
332	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IL2(1), IL2RA(1), IL2RB(2), IL2RG(5), JAK1(9), JAK3(12), JUN(4), LCK(2), MAP2K1(3), MAPK3(8), MAPK8(5), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5), SYK(8)	13446116	141	106	130	41	56	5	39	18	23	0	0.336	1.000	1.000
333	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(2), CDC42(4), CREB3(5), CREB5(11), DUSP1(3), DUSP10(4), EEF2K(7), EIF4E(2), ELK1(1), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K10(2), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(6), MKNK2(3), MYEF2(5), NFKB1(3), NR2C2(7), SRF(4), TRAF6(1)	19295118	146	106	144	48	73	7	32	13	21	0	0.762	1.000	1.000
334	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOX1(8), BCAT1(4), BCKDHA(4), BCKDHB(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), HMGCL(1), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), PCCA(4), PCCB(4), SDS(2)	20998937	140	106	137	55	79	8	16	15	22	0	0.962	1.000	1.000
335	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(2), CDKN1A(38), GNAQ(3), MARCKS(2), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SP1(10), SP3(3), SYT1(6)	12217340	145	105	137	36	57	11	23	10	39	5	0.560	1.000	1.000
336	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(5), CAPN2(2), CAPNS2(1), CXCR3(3), EGF(17), EGFR(7), HRAS(21), ITGA1(7), ITGB1(3), MAPK3(8), MYL2(4), MYLK(15), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTK2(15), PXN(3), TLN1(17)	18950043	154	105	146	48	63	11	44	12	24	0	0.512	1.000	1.000
337	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(9), CALCRL(8), CD97(5), CRHR1(4), CRHR2(3), ELTD1(10), EMR1(6), EMR2(6), GHRHR(5), GIPR(3), GLP1R(3), GLP2R(3), GPR64(7), LPHN1(9), LPHN2(23), LPHN3(21), SCTR(4), VIPR1(1), VIPR2(4)	15363566	141	104	141	67	52	7	41	15	26	0	0.940	1.000	1.000
338	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(10), ACO1(4), ACO2(5), CLYBL(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), OGDHL(10), PC(10), PCK1(9), PCK2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3)	17417733	142	104	138	57	77	4	31	13	17	0	0.836	1.000	1.000
339	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(3), CHUK(7), ELK1(1), FOS(4), IKBKB(11), IRAK1(3), JUN(4), LY96(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), PPARA(1), RELA(6), TLR10(12), TLR2(3), TLR3(10), TLR4(6), TLR6(6), TLR7(9), TLR9(12), TOLLIP(3), TRAF6(1)	21134052	151	104	149	49	79	8	24	11	29	0	0.700	1.000	1.000
340	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), CFL1(1), GNAQ(3), GNAS(12), GNB1(7), HRAS(21), LIMK1(6), MAP2K1(3), MAPK3(8), MYL2(4), NOX1(4), PIK3C2G(11), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2(15), RAF1(4), ROCK2(15)	14578472	147	103	137	39	71	8	34	18	16	0	0.453	1.000	1.000
341	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(21), BAIAP2(5), CASP1(9), CASP3(3), CASP7(5), CASP8(14), GAPDH(3), INSR(10), ITCH(12), MAGI1(15), MAGI2(17), RERE(16), WWP1(5), WWP2(5)	13988690	140	103	136	37	80	4	27	13	16	0	0.302	1.000	1.000
342	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(3), GTF2B(2), GTF2E1(7), GTF2F1(5), HDAC3(1), NCOA1(25), NCOA2(12), NCOA3(16), NCOR2(19), POLR2A(13), RARA(6), RXRA(25), TBP(2)	14408276	143	103	127	44	80	5	26	9	23	0	0.664	1.000	1.000
343	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), COMT(3), DBH(4), DCT(9), DDC(8), FAH(3), GOT1(2), GSTZ1(2), HGD(4), HPD(4), MAOA(4), MAOB(2), TAT(5), TH(2), TPO(16), TYR(12)	18344190	141	103	141	43	59	3	40	14	25	0	0.227	1.000	1.000
344	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(7), ACTN2(10), CAPN1(5), CAPNS2(1), ITGA1(7), ITGB1(3), ITGB3(9), PTK2(15), PXN(3), RAC1(4), SPTAN1(68), SRC(5), TLN1(17)	16549937	158	103	157	43	79	7	24	9	39	0	0.284	1.000	1.000
345	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(5), ARSB(8), ARSD(7), ARSE(2), CYP11B1(6), CYP11B2(13), HSD11B2(3), HSD17B2(6), HSD17B3(1), HSD17B8(4), HSD3B1(5), HSD3B2(5), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4)	15863593	127	102	127	35	61	8	30	16	12	0	0.163	1.000	1.000
346	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(4), CSF1R(11), DDX20(10), E2F1(3), E2F4(2), ETS1(5), ETS2(5), ETV3(1), FOS(4), HDAC2(3), HDAC5(6), HRAS(21), JUN(4), NCOR2(19), RBL1(9), RBL2(9), SIN3A(12), SIN3B(5)	14959461	133	101	123	36	58	1	36	14	24	0	0.242	1.000	1.000
347	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3)	13350597	140	100	136	41	50	6	36	14	33	1	0.399	1.000	1.000
348	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3)	13350597	140	100	136	41	50	6	36	14	33	1	0.399	1.000	1.000
349	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(8), FUCA1(2), FUCA2(6), GALNS(3), GBA(4), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NAGLU(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5), SPAM1(2)	19832019	133	100	132	43	71	3	26	19	14	0	0.387	1.000	1.000
350	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAA2(2), ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(1), AKR1C4(5), AKR1D1(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), HSD3B7(2), LIPA(3), RDH12(2), RDH13(1), SLC27A5(9), SOAT1(5), SOAT2(1), SRD5A1(5)	18295273	137	99	131	47	69	8	27	10	23	0	0.428	1.000	1.000
351	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(11), ELK1(1), EPO(2), EPOR(5), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PLCG1(12), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5)	12505991	130	98	119	33	63	5	27	13	22	0	0.213	1.000	1.000
352	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(6), CHIA(7), CHIT1(7), CMAS(2), CTBS(2), CYB5R1(4), CYB5R3(4), GFPT1(5), GFPT2(5), GNE(8), GNPDA1(3), GNPDA2(2), GNPNAT1(3), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NAGK(5), NPL(2), PGM3(2), RENBP(4), UAP1(5)	16623480	139	97	138	48	76	7	26	15	15	0	0.752	1.000	1.000
353	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(4), CDK7(6), ERCC3(7), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F2(2), GTF2H1(4), GTF2H4(1), ILK(3), MNAT1(4), POLR1A(18), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3B(6), POLR3D(1), POLR3E(4), POLR3H(2), TAF12(2), TAF13(2), TAF5(4), TAF6(8), TAF7(3), TAF9(7), TBP(2)	20384628	145	97	143	56	87	8	17	12	21	0	0.971	1.000	1.000
354	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(1), B4GALT1(4), B4GALT2(1), G6PC(2), G6PC2(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANC(7), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), LCT(16), MGAM(16), PFKL(2), PFKM(5), PFKP(4), PGM1(3), PGM3(2), RDH12(2), RDH13(1), UGP2(9)	22312520	134	96	131	68	69	5	26	14	20	0	0.989	1.000	1.000
355	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(29), ASAH1(4), CAMP(1), CASP3(3), CERK(2), CREB3(5), CREB5(11), CXCL2(1), DAG1(3), EPHB2(10), FOS(4), GNAQ(3), ITPKA(4), ITPKB(5), JUN(4), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5)	16506815	132	96	129	41	65	4	30	12	21	0	0.644	1.000	1.000
356	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(4), CAD(16), CPS1(13), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), GMPS(5), GOT1(2), GPT(2), GPT2(1), GSS(7), NADSYN1(6), PPAT(4), QARS(6)	19339820	126	95	125	50	63	10	24	13	16	0	0.923	1.000	1.000
357	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), HRH1(9), HRH2(1), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5)	14857312	119	95	116	67	59	5	34	11	10	0	0.847	1.000	1.000
358	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(28), ACADL(2), ACADM(1), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SDS(2), SUCLA2(2), SUCLG1(2), SUCLG2(3)	19322692	127	95	126	45	68	5	19	16	19	0	0.855	1.000	1.000
359	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(2), CHUK(7), EGR2(3), EGR3(3), GNAQ(3), MAP3K1(10), MYC(2), NFATC1(14), NFATC2(13), NFKB1(3), NFKBIA(6), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), SYT1(6), VIPR2(4)	16257616	136	95	136	44	64	12	29	8	23	0	0.658	1.000	1.000
360	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(3), COPS5(1), EDN1(2), EP300(77), EPO(2), HIF1A(6), JUN(4), NOS3(11), P4HB(6), VHL(2)	9849708	123	94	117	29	54	6	11	16	35	1	0.409	1.000	1.000
361	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(3), ARRB2(4), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CLCA1(8), CLCA2(5), CLCA4(12), CNGA3(4), CNGB1(13), GNAL(4), GUCA1B(1), GUCA1C(2), PDE1C(15), PRKACA(2), PRKACB(4), PRKACG(2), PRKG1(10), PRKG2(8), PRKX(1)	17727032	130	94	130	57	67	5	24	14	20	0	0.969	1.000	1.000
362	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SDS(2), SMS(1), UPB1(4)	16930150	121	93	120	47	54	9	25	18	15	0	0.884	1.000	1.000
363	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(16), C5(9), C6(9), C7(4), ICAM1(7), IL1A(1), IL6(4), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELP(7), SELPLG(3), TNF(4), VCAM1(14)	14431991	124	93	124	42	66	7	25	11	15	0	0.668	1.000	1.000
364	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(2), DLG4(6), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), NOS1(15), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), SYT1(6)	14795900	127	93	124	43	49	12	31	17	17	1	0.511	1.000	1.000
365	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), GCK(1), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), KHK(1), MPI(7), PFKFB1(5), PFKFB3(8), PFKM(5), PFKP(4), PMM1(6), PMM2(2), SORD(1), TPI1(1)	13797654	117	92	114	50	59	4	24	14	16	0	0.827	1.000	1.000
366	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(2), ALOX15(5), ALOX5(4), CBR1(2), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(6), GGT1(5), LPO(8), LTA4H(3), MPO(4), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3), TPO(16)	16145160	124	92	123	47	59	5	30	11	18	1	0.564	1.000	1.000
367	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), DAG1(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFAT5(15), PDE6A(4), PDE6B(5), PDE6C(5), PDE6H(1), SLC6A13(2), TF(4)	20732514	130	92	128	64	76	5	23	9	17	0	0.993	1.000	1.000
368	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), F2RL3(2), GNAI1(4), GNB1(7), HRAS(21), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), PLA2G4A(1), PLCB1(17), PRKCA(3), PTGS1(2), PTK2(15), RAF1(4), SRC(5), SYK(8), TBXAS1(3)	14171759	118	91	109	43	48	9	32	13	16	0	0.880	1.000	1.000
369	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(4), B4GALT2(1), FBP2(2), G6PC(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANAB(16), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), LCT(16), MGAM(16), PFKM(5), PFKP(4), PGM1(3), PGM3(2)	18802492	126	90	125	59	64	4	28	12	18	0	0.959	1.000	1.000
370	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ACAA2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), SOAT2(1), SRD5A1(5)	13483670	116	89	111	32	53	8	26	10	19	0	0.154	1.000	1.000
371	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(7), GPRC5A(2), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM7(12), GRM8(8)	12244303	110	89	109	46	46	6	31	13	14	0	0.591	1.000	1.000
372	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(3), DLAT(6), DLD(7), DLST(1), FH(7), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), PC(10), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PDK1(2), PDK2(2), PDK3(1), PDK4(1), PDP2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3)	16514949	124	89	119	43	67	5	29	10	13	0	0.698	1.000	1.000
373	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(7), APC(29), AXIN1(4), BTRC(4), CTNNB1(15), DLL1(9), DVL1(5), FZD1(4), GSK3B(5), NOTCH1(17), PSEN1(8)	12262160	107	89	103	27	56	3	21	4	21	2	0.437	1.000	1.000
374	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(4), BIRC2(3), BIRC3(3), CASP3(3), CASP8(14), CFLAR(2), FADD(7), JUN(4), MAP2K4(4), MAP3K3(3), MAP3K7(8), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR2C2(7), RALBP1(2), RIPK1(7), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	15779448	126	89	121	34	78	5	17	8	18	0	0.277	1.000	1.000
375	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(4), ARSB(8), ARSD(7), ARSE(2), ASAH1(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(7), SMPD2(2), SPTLC1(4), SPTLC2(5), UGCG(3)	13934575	109	88	109	34	52	5	26	14	12	0	0.396	1.000	1.000
376	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(6), CAP1(12), CCNB1(5), CDC25C(2), GNAI1(4), GNAS(12), GNB1(7), HRAS(21), MAPK3(8), MYT1(10), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RPS6KA1(5), SRC(5)	11955968	123	88	114	30	49	6	39	13	16	0	0.111	1.000	1.000
377	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(6), AP2M1(2), BIN1(5), CALM1(2), CALM2(2), DNM1(13), EPN1(1), EPS15(10), NME1(1), NME2(3), PICALM(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYNJ1(20), SYNJ2(8), SYT1(6)	12615416	111	88	111	32	60	5	13	14	19	0	0.610	1.000	1.000
378	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), AOC2(5), AOC3(6), ASPA(2), CNDP1(4), DDC(8), HAL(7), HARS(6), HDC(6), HNMT(3), MAOA(4), MAOB(2), PRPS1(3), PRPS2(1)	14173380	101	86	100	33	41	4	28	10	18	0	0.440	1.000	1.000
379	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(7), IFNA1(1), IFNB1(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL1RN(1), IL6(4), IRAK1(3), IRAK2(5), IRAK3(9), JUN(4), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), TGFB1(3), TGFB3(1), TNF(4), TOLLIP(3), TRAF6(1)	17179234	118	86	116	39	64	3	17	9	25	0	0.727	1.000	1.000
380	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(6), EPHB2(10), F2(3), F2RL1(5), F2RL2(2), F2RL3(2), JUN(4), MAP2K5(4), MAPK7(3), MAPK8(5), MYEF2(5), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RAF1(4), RASAL1(8), SRC(5), TEC(10), VAV1(8)	15908002	121	86	119	43	58	12	21	15	15	0	0.754	1.000	1.000
381	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(17), EGFR(7), MAP2K1(3), MAP3K1(10), MAPK14(3), NCOR2(19), RARA(6), RXRA(25), THRA(2), THRB(1)	9957695	93	85	80	25	43	4	24	5	17	0	0.314	1.000	1.000
382	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(6), CBS(2), CTH(5), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(12), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), METTL2B(3), METTL6(5), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SCLY(2), SEPHS1(2), SEPHS2(1), WBSCR22(7)	14482008	101	85	97	38	55	4	22	9	11	0	0.719	1.000	1.000
383	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(5), DARS(3), EPRS(12), FARS2(1), GARS(6), HARS(6), IARS(6), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), NARS(4), QARS(6), RARS(6), SARS(5), TARS(9), WARS(5), WARS2(2), YARS(5)	18745148	118	83	118	39	70	6	17	8	17	0	0.734	1.000	1.000
384	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), AGT(3), AGTR2(4), EDN1(2), EDNRA(4), EDNRB(8), EGF(17), EGFR(7), FOS(4), HRAS(21), JUN(4), MYC(2), NFKB1(3), PLCG1(12), PRKCA(3), RELA(6)	11964577	106	83	96	38	46	8	32	5	15	0	0.743	1.000	1.000
385	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(2)	12766161	105	83	105	47	48	4	26	8	19	0	0.875	1.000	1.000
386	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(5), ALOX5(4), CYP1A2(4), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), HSD3B7(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), RDH12(2), RDH13(1)	13924185	97	83	97	40	44	4	21	12	16	0	0.801	1.000	1.000
387	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(13), APOA1(2), APOA4(4), APOC1(1), APOC2(1), APOC3(1), APOE(2), CETP(2), CYP7A1(10), DGAT1(3), HMGCR(7), LCAT(3), LDLR(10), LIPC(6), LPL(4), LRP1(36), SCARB1(3), SOAT1(5)	15957453	113	83	113	46	57	5	22	10	19	0	0.806	1.000	1.000
388	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(11), EGF(17), EGFR(7), GRB2(3), MET(19), PDGFRA(16), PRKCA(3), SH3GLB1(1), SH3GLB2(1), SH3KBP1(8), SRC(5)	11321290	99	82	98	38	42	5	30	12	10	0	0.888	1.000	1.000
389	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(3), BAX(2), CASP8(14), CYCS(1), FADD(7), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFKB1(3), NSMAF(12), RAF1(4), RELA(6), RIPK1(7), SMPD1(7), TNFRSF1A(5), TRADD(2), TRAF2(5)	11874769	108	82	105	30	60	4	11	11	22	0	0.385	1.000	1.000
390	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ACADM(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SMS(1), SRM(3), UPB1(4)	15706845	106	82	106	39	45	8	22	16	15	0	0.796	1.000	1.000
391	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(7), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), GZMB(2), LMNA(5), LMNB1(4), LMNB2(7), PRF1(7)	11239631	93	81	93	34	53	4	16	7	13	0	0.920	1.000	1.000
392	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), ESCO1(3), ESCO2(3), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MIF(1), MPO(4), NAT6(1), PNPLA3(4), PRDX6(5), SH3GLB1(1), TAT(5), TPO(16)	19882147	105	81	105	27	47	4	30	9	15	0	0.166	1.000	1.000
393	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), C1GALT1(4), C1GALT1C1(3), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GCNT1(5), GCNT3(3), GCNT4(5), OGT(5), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(8), WBSCR17(9)	18825856	116	81	116	35	55	8	28	11	14	0	0.501	1.000	1.000
394	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(10), ABCC2(12), ABCG2(10), BCHE(9), CES1(4), CES2(7), CYP3A4(9), CYP3A5(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3)	13357273	97	81	97	31	47	4	23	11	12	0	0.404	1.000	1.000
395	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(5), BLVRB(1), CP(5), CPOX(5), EPRS(12), FECH(3), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UROD(4), UROS(4)	15967504	103	81	103	39	47	4	18	14	20	0	0.919	1.000	1.000
396	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), HMGCL(1), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(6), PDHB(2), SDHB(2), SDS(2)	15013646	104	80	103	48	54	6	17	13	14	0	0.982	1.000	1.000
397	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(7), FADD(7), IKBKB(11), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(10), MAP3K7(8), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TLR4(6), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1)	14056195	103	80	101	29	59	3	13	5	23	0	0.495	1.000	1.000
398	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(49), MAP2(16), PPP1CA(8), PPP2CA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5), PRKCE(5)	10617251	99	79	97	19	58	4	13	15	9	0	0.259	1.000	1.000
399	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(4), GRB2(3), HRAS(21), IL3RA(6), JAK2(8), MAP2K1(3), MAPK3(8), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5)	10322024	101	79	92	28	42	3	23	10	23	0	0.393	1.000	1.000
400	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(3), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), ILVBL(3), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCDC(1), PPCS(9), UPB1(4), VNN1(3)	10082732	95	78	91	41	43	5	20	17	10	0	0.968	1.000	1.000
401	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(2), MRPS7(5), RPL10A(3), RPL10L(3), RPL11(2), RPL13(3), RPL19(2), RPL22L1(2), RPL23A(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL3L(3), RPL41(1), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPS12(3), RPS13(2), RPS16(4), RPS18(6), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1), RPS5(1), RPS6(5), RPS7(2), RPS8(2), RPS9(3), RPSA(4)	13137032	108	78	107	40	55	9	26	5	13	0	0.552	1.000	1.000
402	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(2), CHUK(7), CRADD(1), IKBKB(11), JUN(4), LTA(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP4K2(5), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5)	13892378	103	78	100	34	66	4	11	4	18	0	0.648	1.000	1.000
403	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(14), CR2(17), FCGR2B(2), HLA-DRA(4), HLA-DRB1(1), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19)	8820248	90	77	89	30	38	5	23	10	14	0	0.597	1.000	1.000
404	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2)	8041527	99	77	96	22	43	6	14	13	22	1	0.405	1.000	1.000
405	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(8), GNA12(3), GNA13(12), GNAQ(3), GNB1(7), MYL2(4), MYLK(15), PLCB1(17), PPP1R12B(10), PRKCA(3), ROCK1(8)	12072772	102	77	95	31	57	3	19	15	8	0	0.701	1.000	1.000
406	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), XYLB(8)	15913885	102	76	98	29	49	7	13	16	17	0	0.484	1.000	1.000
407	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), P4HB(6), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(6)	14352855	85	76	84	40	40	6	22	6	11	0	0.999	1.000	1.000
408	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(10), BCAR1(6), CSK(7), CTNNA1(6), CTNNA2(22), CTNNB1(15), PTK2(15), PXN(3), SRC(5), VCL(4)	11096019	100	75	96	23	47	8	24	11	10	0	0.112	1.000	1.000
409	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(6), F2(3), F2R(2), F5(24), F7(8), FGA(17), FGB(5), FGG(7), PROC(2), PROS1(14), SERPINC1(7)	9579714	95	75	93	22	54	4	18	9	10	0	0.208	1.000	1.000
410	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), ADC(6), AGMAT(1), ALDH18A1(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), ASS1(2), CPS1(13), GATM(3), MAOA(4), MAOB(2), NAGS(1), ODC1(4), OTC(2), SAT2(3), SMS(1), SRM(3)	17041271	98	75	95	28	48	3	18	14	15	0	0.202	1.000	1.000
411	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5)	11757472	85	75	84	28	44	1	20	10	10	0	0.492	1.000	1.000
412	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(6), AP2M1(2), BAD(3), BTK(5), EEA1(13), GRASP(3), GSK3A(2), GSK3B(5), LYN(5), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PLCG1(12), PRKCE(5), PRKCZ(4), RAB5A(2), RAC1(4), RPS6KB1(4), VAV2(8)	14514204	99	75	99	32	57	5	10	13	13	1	0.471	1.000	1.000
413	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(6), APEX1(1), CREBBP(50), DFFA(6), DFFB(1), GZMA(4), GZMB(2), HMGB2(6), NME1(1), PRF1(7), SET(3)	6128157	87	75	84	24	28	2	20	9	27	1	0.481	1.000	1.000
414	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(3), DRD1(2), DRD2(5), GRM1(22), PLCB1(17), PPP1CA(8), PPP1R1B(5), PPP2CA(2), PPP3CA(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	9327568	101	74	101	26	50	3	24	12	12	0	0.128	1.000	1.000
415	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(6), ALDOB(3), ALDOC(2), DERA(3), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKL(2), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1), TKTL1(7), TKTL2(5)	14132949	90	74	90	50	37	4	27	12	10	0	0.994	1.000	1.000
416	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), PON1(6), PON2(2), PON3(3)	10449981	96	73	92	40	42	4	28	7	15	0	0.841	1.000	1.000
417	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DPAGT1(6), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(9), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), RPN1(3), RPN2(5), ST6GAL1(4)	11514005	89	73	89	34	42	4	19	15	9	0	0.747	1.000	1.000
418	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), PC(10), PCK1(9), SDHA(9), SDHB(2), SUCLA2(2), SUCLG1(2), SUCLG2(3)	12013419	88	72	87	29	50	2	20	6	10	0	0.529	1.000	1.000
419	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(5), PGAP1(5), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGW(5), PIGZ(3)	13765901	94	72	93	33	46	2	26	5	15	0	0.393	1.000	1.000
420	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AGPS(5), CHPT1(6), ENPP2(7), ENPP6(3), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(4), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PPAP2A(5), PPAP2B(3), PPAP2C(1)	13463168	89	72	89	45	47	2	11	11	18	0	0.994	1.000	1.000
421	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(4), BECN1(2), GABARAP(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNG(2), PIK3C3(11), PIK3R4(11), PRKAA1(9), PRKAA2(7), ULK1(9), ULK2(9), ULK3(1)	12161636	90	72	89	26	54	7	17	7	5	0	0.478	1.000	1.000
422	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), ESRRA(2), HDAC5(6), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PPARA(1), PPP3CA(7), PPP3CB(7), PPP3CC(4), SLC2A4(4), SYT1(6), YWHAH(2)	11670640	93	72	93	43	49	9	9	12	14	0	0.970	1.000	1.000
423	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA2(2), ANXA3(3), ANXA4(1), ANXA5(4), ANXA6(6), CYP11A1(1), EDN1(2), EDNRA(4), EDNRB(8), HPGD(1), HSD11B2(3), PLA2G4A(1), PRL(3), PTGDR(3), PTGDS(1), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(6), S100A6(2), TBXAS1(3)	12021185	84	72	84	37	35	5	32	3	9	0	0.892	1.000	1.000
424	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(3), AGTR1(3), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), REN(3)	14486384	84	71	83	34	34	6	27	5	12	0	0.996	1.000	1.000
425	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(4), HRAS(21), JUN(4), MAP2K1(3), MAPK3(8), MYC(2), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RAF1(4), RELA(6), TNF(4)	9053064	88	71	78	26	38	3	24	8	15	0	0.446	1.000	1.000
426	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(12), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CYP2C19(7), CYP2C9(3), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1)	18013869	85	71	84	28	37	2	26	5	15	0	0.700	1.000	1.000
427	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(1), ASRGL1(3), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), HAL(7)	12378382	87	71	86	27	39	6	20	9	13	0	0.598	1.000	1.000
428	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), RFK(1), TYR(12)	8779717	88	69	86	28	45	4	19	8	12	0	0.756	1.000	1.000
429	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), SELE(7), SELP(7)	9229964	82	69	81	31	46	3	17	6	10	0	0.816	1.000	1.000
430	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCS(9), UPB1(4)	8119133	85	69	81	35	38	5	16	16	10	0	0.963	1.000	1.000
431	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(7), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP7(5), CASP8(14), CASP9(6), DFFA(6), DFFB(1), GZMB(2), PRF1(7), SCAP(9), SREBF1(6), SREBF2(8)	10509336	81	69	81	28	42	4	16	6	13	0	0.723	1.000	1.000
432	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), NDST1(2), NDST2(2), NDST3(7), NDST4(13)	11958635	77	68	77	36	40	5	15	8	9	0	0.920	1.000	1.000
433	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(9), IL22(1), IL22RA1(4), IL22RA2(3), JAK1(9), JAK2(8), JAK3(12), SOCS3(1), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), TYK2(9)	10651332	81	68	80	32	31	4	14	7	25	0	0.844	1.000	1.000
434	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(7), IFNG(2), IKBKB(11), IL2(1), JUN(4), MAP3K1(10), MAP3K5(14), MAP4K5(4), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), TNFRSF9(2), TNFSF9(2), TRAF2(5)	11162507	86	67	84	28	53	2	12	3	16	0	0.767	1.000	1.000
435	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(4), ADSL(4), ADSS(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), CAD(16), CRAT(10), DARS(3), DDO(1), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), PC(10)	15154734	93	67	92	40	53	3	18	10	9	0	0.907	1.000	1.000
436	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8), MASP1(12), MASP2(5), MBL2(1)	12378608	87	67	87	29	34	5	28	10	10	0	0.718	1.000	1.000
437	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), PGD(5)	10468473	90	67	90	36	45	3	22	5	15	0	0.710	1.000	1.000
438	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(9), DYRK1B(5), GLI2(16), GLI3(19), GSK3B(5), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), SHH(6), SMO(8), SUFU(2)	9663705	92	67	91	24	33	4	34	5	16	0	0.210	1.000	1.000
439	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), LTA(1), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNFAIP3(7), TNFRSF1B(6), TRAF2(5), TRAF3(2)	13016567	87	67	87	22	53	4	12	3	15	0	0.261	1.000	1.000
440	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(28), ACACB(21), FASN(12), MCAT(2), OLAH(4), OXSM(8)	9087372	75	66	73	20	42	6	10	10	7	0	0.161	1.000	1.000
441	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2)	13668577	90	66	89	40	55	4	13	8	10	0	0.978	1.000	1.000
442	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(5), AGT(3), AGTR1(3), AGTR2(4), ANPEP(6), CMA1(1), CPA3(7), CTSA(3), CTSG(4), ENPEP(9), LNPEP(7), MAS1(2), MME(13), NLN(2), REN(3), THOP1(6)	12312028	89	66	87	34	41	3	20	12	13	0	0.752	1.000	1.000
443	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7)	8727356	78	65	73	24	40	2	18	9	9	0	0.379	1.000	1.000
444	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(6), CHAT(5), COMT(3), DBH(4), DDC(8), GAD1(8), GAD2(6), HDC(6), MAOA(4), PAH(11), SLC18A3(5), TH(2), TPH1(3)	8271059	73	64	73	39	25	3	25	8	12	0	0.982	1.000	1.000
445	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C8B(3), C9(8), MASP1(12)	12095257	84	64	84	28	34	5	27	9	9	0	0.717	1.000	1.000
446	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5)	9523377	69	63	69	21	35	1	16	9	8	0	0.472	1.000	1.000
447	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(6), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PCYT1A(2), PCYT1B(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7)	8144103	73	62	69	22	42	3	12	8	8	0	0.458	1.000	1.000
448	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(1), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), HAL(7)	11083784	74	62	73	21	35	4	14	9	12	0	0.426	1.000	1.000
449	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(4), GCK(1), GFPT1(5), GNE(8), GNPDA1(3), GNPDA2(2), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), PGM3(2), RENBP(4), UAP1(5)	9831287	75	61	74	34	37	6	17	5	10	0	0.966	1.000	1.000
450	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTFMT(2), MTR(7), SRM(3), TAT(5)	11994594	71	61	71	28	35	4	16	8	8	0	0.817	1.000	1.000
451	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), ST3GAL6(6), ST8SIA1(3)	9371057	79	61	77	29	39	1	18	12	9	0	0.599	1.000	1.000
452	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), BST1(4), CD38(1), ENPP1(7), ENPP3(6), NADK(4), NADSYN1(6), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(8), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT12(3), QPRT(4)	12532409	74	61	73	29	42	5	11	4	12	0	0.894	1.000	1.000
453	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(28), CPT1A(7), LEP(1), LEPR(8), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3)	8483238	67	61	67	21	34	4	9	10	10	0	0.701	1.000	1.000
454	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1)	11903459	73	61	73	41	30	3	23	10	7	0	0.991	1.000	1.000
455	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(3), GOSR1(2), GOSR2(1), SNAP23(3), SNAP25(4), SNAP29(4), STX10(3), STX11(2), STX12(3), STX16(2), STX18(2), STX19(2), STX2(5), STX3(5), STX4(3), STX5(2), STX6(2), STX7(2), STX8(2), TSNARE1(4), USE1(4), VAMP1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(3), VAMP8(2), VTI1A(1), VTI1B(6), YKT6(1)	9641982	78	60	78	28	46	3	16	7	6	0	0.731	1.000	1.000
456	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(7), ARHGAP5(12), ARHGDIB(1), CASP1(9), CASP10(1), CASP3(3), CASP8(14), CASP9(6), CYCS(1), GZMB(2), JUN(4), PRF1(7)	7525762	67	59	65	22	30	4	12	10	11	0	0.844	1.000	1.000
457	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(7), CYP51A1(4), DHCR24(3), DHCR7(3), EBP(1), FDPS(6), GGCX(7), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(4), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4), TM7SF2(1), VKORC1(4)	11122542	72	59	72	19	38	3	15	8	8	0	0.178	1.000	1.000
458	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), NAGLU(5), SPAM1(2)	11836355	70	59	70	23	40	3	11	11	5	0	0.453	1.000	1.000
459	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(9), PSMC3(5), PSMD1(7), PSMD11(4), PSMD12(4), PSMD2(6), PSMD6(3)	9340626	72	59	71	23	44	1	13	8	6	0	0.702	1.000	1.000
460	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3E(2), CD3G(2), CXCR3(3), ETV5(4), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), JAK2(8), JUN(4), MAP2K6(1), MAPK14(3), MAPK8(5), STAT4(9), TYK2(9)	10798436	74	59	72	38	36	2	15	6	15	0	0.997	1.000	1.000
461	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(4), IL6R(4), JAK1(9), JAK2(8), JAK3(12), PIAS3(6), PTPRU(7), REG1A(8), SRC(5), STAT3(6)	8831183	70	59	70	18	33	2	21	4	10	0	0.155	1.000	1.000
462	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(5), F13A1(8), F2(3), F2R(2), FGA(17), FGB(5), FGG(7), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6)	7811469	68	58	67	19	31	2	16	10	9	0	0.504	1.000	1.000
463	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(3), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), NAGS(1), OAT(1), ODC1(4), OTC(2), PYCR1(3), SMS(1)	10130109	72	58	70	24	40	2	12	9	9	0	0.590	1.000	1.000
464	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), NCK1(2), NCKAP1(12), NTRK1(7), PIR(2), RAC1(4), WASF1(5), WASF2(7), WASF3(5), WASL(2)	8905019	70	57	68	23	37	3	14	5	11	0	0.802	1.000	1.000
465	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(4), ARFGEF2(18), CLTA(3), CLTB(1), COPA(12), GBF1(16), GPLD1(5), KDELR2(4), KDELR3(1)	9493504	68	56	68	22	44	6	7	1	10	0	0.502	1.000	1.000
466	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(6), GNAS(12), GNB1(7), PPP2CA(2), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	8942055	72	56	71	16	33	6	17	8	8	0	0.174	1.000	1.000
467	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD2(2), CD33(6), CD5(3), CD7(3), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL5(1), ITGAX(3), TLR2(3), TLR4(6), TLR7(9), TLR9(12)	10838493	63	55	63	28	30	5	14	6	8	0	0.813	1.000	1.000
468	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL5(1), JUNB(5), MAF(3), MAP2K3(6), MAPK14(3), NFATC1(14), NFATC2(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7020066	75	55	75	28	27	5	24	7	12	0	0.675	1.000	1.000
469	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(6), B4GALNT1(2), GLB1(5), HEXA(3), HEXB(2), LCT(16), SLC33A1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL5(5), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2)	9619087	64	55	64	30	33	3	13	11	4	0	0.906	1.000	1.000
470	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TKTL1(7), TKTL2(5), TPI1(1)	11714053	63	55	63	31	29	1	20	9	4	0	0.941	1.000	1.000
471	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIK(1), BIRC2(3), BIRC3(3), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), DIABLO(3)	7837497	64	55	63	24	34	4	13	1	12	0	0.938	1.000	1.000
472	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(4), CD3E(2), CD3G(2), CD8A(2), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3)	6263281	65	55	65	25	31	3	16	5	10	0	0.605	1.000	1.000
473	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(4), CD3E(2), CD3G(2), CD4(3), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3)	6570969	66	55	66	26	32	2	16	6	10	0	0.647	1.000	1.000
474	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8)	10164025	69	54	69	25	29	5	22	5	8	0	0.837	1.000	1.000
475	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELE(7)	7028740	62	54	61	21	34	1	13	5	9	0	0.677	1.000	1.000
476	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTR(7)	10102031	61	54	61	23	30	3	15	7	6	0	0.726	1.000	1.000
477	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR7(3), CD28(4), CD4(3), CXCR3(3), CXCR4(4), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL4R(6), IL5(1), TGFB1(3), TGFB3(1)	11623419	69	54	69	34	28	2	16	13	10	0	0.943	1.000	1.000
478	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(5), FYN(7), LRP8(7), RELN(36), VLDLR(6)	8197876	69	54	69	20	33	4	18	9	5	0	0.601	1.000	1.000
479	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), TNFAIP3(7), TRAF3(2), TRAF6(1)	10519839	66	53	66	18	41	3	7	1	14	0	0.469	1.000	1.000
480	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1D(3), CSNK1E(3), NPAS2(8), NR1D1(3), PER1(6), PER2(6), PER3(12)	9864281	61	53	61	26	30	1	16	4	10	0	0.951	1.000	1.000
481	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(2), CCL2(1), CCR5(6), CXCL12(6), CXCR4(4), FOS(4), GNAQ(3), JUN(4), MAPK14(3), MAPK8(5), PLCG1(12), PRKCA(3), PTK2B(6), SYT1(6)	8024865	67	52	65	24	29	5	11	11	11	0	0.699	1.000	1.000
482	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(13), EGF(17), EGFR(7), HGS(11), RAB5A(2), TF(4), TFRC(9)	7521093	63	52	62	22	35	4	11	6	7	0	0.887	1.000	1.000
483	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(5), AFMID(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6)	7826098	59	52	58	19	28	3	19	2	7	0	0.498	1.000	1.000
484	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(3), ATIC(2), FTCD(4), GART(7), MTFMT(2), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3)	11036760	64	52	64	26	30	4	14	6	10	0	0.875	1.000	1.000
485	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(4), ITPKA(4), PDE1A(8), PDE1B(4), PLCB1(17), PLCB2(6), PRL(3), TRH(6)	6429814	57	52	56	19	27	2	16	8	4	0	0.619	1.000	1.000
486	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(7), BRAF(9), CAMP(1), CREB3(5), CREB5(11), RAF1(4), SNX13(5), SRC(5), TERF2IP(4)	6451866	55	51	55	20	24	3	8	11	9	0	0.880	1.000	1.000
487	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(5), ACAT2(1), ACOT11(12), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), FN3K(2), GCDH(6), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1)	15167842	65	50	64	23	35	1	16	3	10	0	0.856	1.000	1.000
488	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(3), IL2RG(5), IL4R(6), IRS1(9), JAK1(9), JAK3(12), RPS6KB1(4), SHC1(8), STAT6(9)	8545155	68	50	68	26	31	1	17	9	9	1	0.760	1.000	1.000
489	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(3), ATIC(2), ATP6V0C(3), GART(7), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3)	10448764	61	50	61	25	32	3	14	4	8	0	0.859	1.000	1.000
490	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4)	10241286	61	50	61	22	27	3	11	11	9	0	0.796	1.000	1.000
491	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(2), EPHB1(14), FYN(7), ITGA1(7), ITGB1(3), L1CAM(8), LYN(5), RAP1B(2), SELP(7)	9223404	59	49	59	18	26	3	17	6	7	0	0.563	1.000	1.000
492	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1)	14554566	61	49	60	18	28	2	18	5	8	0	0.579	1.000	1.000
493	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(2), CD3E(2), CD3G(2), CD4(3), CXCR3(3), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), JAK2(8), STAT4(9), TYK2(9)	8489089	58	49	58	28	22	3	15	6	12	0	0.975	1.000	1.000
494	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(9), JAK2(8), JAK3(12), PIAS1(3), PIAS3(6), PTPRU(7), REG1A(8), SOAT1(5)	7938106	59	49	59	19	26	2	18	3	10	0	0.516	1.000	1.000
495	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(4), NR3C1(6), PPARG(13), RXRA(25), TNF(4)	3385167	52	49	36	18	29	2	9	3	9	0	0.643	1.000	1.000
496	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(5), EGR1(7), HRAS(21), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), NGFR(4), RAF1(4)	4755257	61	48	53	23	17	3	22	7	12	0	0.688	1.000	1.000
497	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(7), ICAM1(7), ITGAL(17), ITGB2(7), PRF1(7)	5075094	54	48	53	22	20	0	16	7	11	0	0.651	1.000	1.000
498	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(15), KHK(1), LCT(16), MPI(7), PGM1(3), PYGL(4), PYGM(13), TPI1(1), TREH(5)	7756453	65	48	64	28	33	4	16	5	7	0	0.752	1.000	1.000
499	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6)	7473972	54	48	53	19	25	2	19	2	6	0	0.644	1.000	1.000
500	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(5), B3GAT3(3), B4GALT7(1), CHPF(4), CHST11(2), CHST12(3), CHST14(3), CHST7(2), CHSY1(9), DSE(6), UST(4), XYLT1(6), XYLT2(6)	7961671	55	48	52	30	29	2	13	5	6	0	0.936	1.000	1.000
501	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(7), ITGAL(17), ITGAM(13), ITGB2(7), SELE(7)	5987153	53	48	52	23	29	1	14	3	6	0	0.772	1.000	1.000
502	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), RFK(1), TYR(12)	5664987	62	48	60	22	30	3	15	4	10	0	0.808	1.000	1.000
503	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME2(1), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TPI1(1)	10461276	52	47	52	26	25	1	16	7	3	0	0.941	1.000	1.000
504	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), IDS(4), IDUA(1), LCT(16), NAGLU(5)	8306878	52	47	52	15	31	3	8	7	3	0	0.304	1.000	1.000
505	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(10), ACO1(4), ACO2(5), ACSS1(7), ACSS2(3), FH(7), IDH1(9), IDH2(2), MDH1(3), SUCLA2(2)	7760514	52	47	52	31	26	3	6	9	8	0	0.989	1.000	1.000
506	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), AOC2(5), AOC3(6), CES1(4), DDHD1(11), ESCO1(3), ESCO2(3), LIPA(3), NAT6(1), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(1)	14716988	53	47	53	13	29	4	9	7	4	0	0.371	1.000	1.000
507	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(16), ABCB11(4), ABCB4(11), ABCC1(10), ABCC3(16), GSTP1(2)	8339112	59	47	58	20	35	4	10	5	5	0	0.332	1.000	1.000
508	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(21), MMP14(4), MMP2(7), MMP9(6), RECK(8), TIMP1(2), TIMP2(4), TIMP4(3)	4372162	55	47	47	21	20	3	21	4	7	0	0.760	1.000	1.000
509	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(9), JAK2(8), JAK3(12), MAPK3(8), STAT3(6), TYK2(9)	6769111	52	47	52	24	20	4	12	3	13	0	0.937	1.000	1.000
510	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(1), JAK1(9), PTPRU(7), REG1A(8), STAT1(13), STAT2(4), TYK2(9)	7270570	53	46	52	21	17	3	17	4	11	1	0.681	1.000	1.000
511	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(4), CD86(6), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL2RA(1), IL4R(6)	7382887	48	46	48	20	19	2	13	8	6	0	0.882	1.000	1.000
512	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8)	7318348	53	45	53	19	24	5	16	4	4	0	0.851	1.000	1.000
513	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(3), FOS(4), JUN(4), MAPK3(8), OPRK1(4), POLR2A(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7475395	58	45	56	21	30	3	13	3	9	0	0.678	1.000	1.000
514	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), NTAN1(2), SIRT1(9), SIRT2(2), SIRT5(3), SIRT7(4), VNN2(4)	6900744	48	45	46	15	32	3	3	3	7	0	0.753	1.000	1.000
515	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(3), FH(7), IDH2(2), MDH1(3), OGDH(21), SDHA(9), SUCLA2(2)	5497154	52	45	49	16	25	3	11	7	6	0	0.451	1.000	1.000
516	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(6), CTSD(6), ESR1(5), GREB1(17), HSPB1(1), HSPB2(4), MTA1(5), MTA3(1), PDZK1(2), TUBA8(2)	6210655	49	45	48	16	15	2	23	4	5	0	0.408	1.000	1.000
517	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT2(1), NNMT(3), NNT(8), NT5C(1), NT5E(6), QPRT(4)	8467349	51	45	50	19	30	3	7	4	7	0	0.797	1.000	1.000
518	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(9), FURIN(9), NOTCH1(17), PSEN1(8)	5199560	50	45	48	16	22	3	15	1	7	2	0.461	1.000	1.000
519	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(4), JUN(4), KEAP1(9), MAFG(1), MAFK(1), MAPK14(3), MAPK8(5), NFE2L2(25), PRKCA(3)	5084772	55	44	44	19	31	1	10	6	7	0	0.774	1.000	1.000
520	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(14), ANKRD1(1), CYR61(6), DUSP14(4), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(6), IL1A(1), IL1R1(1), JUND(2), MYOG(2), NR4A3(5), WDR1(3)	6208349	51	44	48	16	32	3	6	3	7	0	0.618	1.000	1.000
521	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(6), ADRB2(3), GNAS(12), PLCE1(11), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAP2B(1)	8621275	55	44	55	20	23	2	15	6	9	0	0.774	1.000	1.000
522	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(4), CD3E(2), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10), TOB1(5), TOB2(2)	6161601	48	44	48	21	23	3	9	2	10	1	0.926	1.000	1.000
523	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2A(2), UBE2B(2), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2H(3), UBE2I(1), UBE2J1(5), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2N(4), UBE2S(2), UBE3A(10)	6125902	53	44	51	17	30	5	5	8	5	0	0.730	1.000	1.000
524	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), SDS(2)	7052603	48	43	47	20	24	2	8	5	9	0	0.806	1.000	1.000
525	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(6), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(2), CPT1A(7), CPT2(5), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(3)	9805244	47	43	47	16	25	1	10	6	5	0	0.727	1.000	1.000
526	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(5), GALNT10(3), GALNT2(8), GALNT3(5), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), WBSCR17(9)	8417000	58	43	58	17	26	4	17	5	6	0	0.409	1.000	1.000
527	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CARS2(7), CDO1(2), CTH(5), GOT1(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MPST(1), SDS(2), SULT1B1(5), SULT1C2(4), SULT1C4(4)	7304186	47	42	46	17	23	5	10	2	7	0	0.757	1.000	1.000
528	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), IMPA2(4), ISYNA1(2), PGM1(3), PGM3(2), TGDS(3)	6757795	50	42	49	26	21	3	13	3	10	0	0.970	1.000	1.000
529	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(4), ACOX1(7), ACOX3(7), ELOVL2(2), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(2), FASN(12), HADHA(4), HSD17B12(3), SCD(2)	8249688	48	42	48	21	20	3	11	5	9	0	0.755	1.000	1.000
530	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(7), CASP3(3), CASP9(6), CYCS(1), DAXX(9), FAS(1), FASLG(1), HSPB1(1), HSPB2(4), IL1A(1), MAPKAPK2(1), MAPKAPK3(3), TNF(4)	6605523	46	42	46	26	21	5	12	1	7	0	0.994	1.000	1.000
531	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(4), HPRT1(1), IMPDH1(1), MTHFD2(6), NME2(3), OAZ1(4), POLD1(10), POLG(8), PRPS2(1), RRM1(4), SRM(3)	7223915	49	41	49	13	22	6	14	1	6	0	0.361	1.000	1.000
532	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(4), CNR2(6), DNMT1(11), MTNR1A(4), MTNR1B(1), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2)	6441056	51	41	51	25	22	4	17	2	6	0	0.695	1.000	1.000
533	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CAMKK1(3), CAMKK2(5), SYT1(6)	6669495	50	40	50	30	27	4	5	5	9	0	0.997	1.000	1.000
534	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(12), ALAS2(5), CPOX(5), FECH(3), PPOX(6), UROD(4), UROS(4)	4349525	44	40	44	19	20	3	4	7	10	0	0.946	1.000	1.000
535	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), NAT1(4), NAT2(1), XDH(11)	4683662	42	40	40	15	24	2	8	5	3	0	0.432	1.000	1.000
536	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(6), CAPN1(5), CAPNS2(1), CDK5(3), CDK5R1(5), CSNK1A1(6), CSNK1D(3), GSK3B(5), MAPT(10), PPP2CA(2)	5334023	46	40	46	29	23	1	10	3	9	0	0.999	1.000	1.000
537	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(2), GSS(7), NFKB1(3), NOX1(4), RELA(6), SOD1(4), TNF(4), XDH(11)	5747866	43	39	43	13	24	0	10	2	7	0	0.318	1.000	1.000
538	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(6), IFNB1(1), JAK1(9), STAT1(13), STAT2(4), TYK2(9)	6297014	45	39	44	16	16	3	9	3	13	1	0.625	1.000	1.000
539	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(3), AGTR1(3), AGTR2(4), BDKRB2(3), KNG1(5), NOS3(11), REN(3)	5659014	43	38	42	21	19	2	13	4	5	0	0.829	1.000	1.000
540	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(3), CASP7(5), DFFA(6), DFFB(1), GZMB(2), HMGB1(4), HMGB2(6), TOP2A(13), TOP2B(5)	5161152	45	38	45	13	28	2	6	5	4	0	0.818	1.000	1.000
541	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(7), ERBB4(11), NRG2(3), NRG3(8), PRKCA(3), PSEN1(8)	5238652	40	38	40	11	16	2	10	4	8	0	0.549	1.000	1.000
542	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(5), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), CHST1(2), CHST2(1), CHST4(3), CHST6(1), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1)	7249622	43	38	42	31	21	0	9	9	4	0	0.997	1.000	1.000
543	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(5), ALOX15B(3), ALOX5(4), DPEP1(2), GGT1(5), LTA4H(3), PLA2G2A(2), PLA2G6(4), PTGDS(1), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3)	8658093	44	37	44	24	20	2	10	5	7	0	0.915	1.000	1.000
544	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR161(8), GPR171(3), GPR18(3), GPR39(4), GPR45(4), GPR65(3), GPR68(5), GPR75(9)	5743118	41	37	40	18	19	3	9	5	5	0	0.461	1.000	1.000
545	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(13), AASS(11), KARS(11)	4073260	39	37	39	12	24	3	7	3	2	0	0.787	1.000	1.000
546	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(2)	5099611	41	37	40	13	25	1	8	5	2	0	0.647	1.000	1.000
547	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5)	7771103	48	37	48	25	30	2	5	6	5	0	0.984	1.000	1.000
548	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), PGM1(3), PGM3(2), TGDS(3)	5940854	44	37	43	23	19	3	11	2	9	0	0.970	1.000	1.000
549	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(12), GNB1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3)	5599472	48	36	47	12	22	5	11	5	5	0	0.373	1.000	1.000
550	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(12), ALAS2(5), CPO(3), FECH(3), GATA1(6), HBB(1), UROD(4), UROS(4)	4456460	43	36	43	15	19	4	4	5	11	0	0.771	1.000	1.000
551	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(7), FADS2(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4)	5864885	40	36	40	23	17	0	10	4	9	0	0.982	1.000	1.000
552	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(3), CSF1(4), CSF3(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(4), IL7(1), LTA(1), TGFB1(3), TGFB3(1), TNF(4)	7668150	40	36	40	16	23	0	10	3	4	0	0.571	1.000	1.000
553	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(9), HSD17B1(1), HSD17B2(6), HSD17B3(1), HSD17B4(5), HSD17B7(3), HSD3B1(5), HSD3B2(5)	4720980	38	36	38	15	22	2	5	5	4	0	0.775	1.000	1.000
554	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(3), MAPK8(5), NFKB1(3), RELA(6), TNFRSF13B(1), TNFRSF13C(3), TNFRSF17(2), TNFSF13(2), TNFSF13B(5), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1)	8408660	46	36	46	14	30	1	7	2	6	0	0.554	1.000	1.000
555	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(21), GNA12(3), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5)	5886779	43	35	43	12	22	1	8	5	7	0	0.591	1.000	1.000
556	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(4), HDAC9(8), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), YWHAH(2)	4358814	38	35	38	15	17	5	5	4	7	0	0.851	1.000	1.000
557	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(6), CREM(3), FHL5(4), FSHB(1), FSHR(5), GNAS(12), XPO1(7)	5604723	38	34	38	16	21	0	7	4	6	0	0.916	1.000	1.000
558	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(10), CS(3), MDH1(3), ME1(5), PC(10), PDHA1(5), SLC25A1(1), SLC25A11(2)	5386137	39	34	39	25	21	0	11	4	3	0	0.983	1.000	1.000
559	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RELA(6)	4778112	38	34	38	11	25	1	8	3	1	0	0.526	1.000	1.000
560	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(7), BAD(3), BAK1(2), BAX(2), BCL10(3), BCL2L1(4), BCL2L11(3), BID(2), CASP9(6), CES1(4)	6211003	36	34	35	11	9	5	9	2	11	0	0.857	1.000	1.000
561	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(2), CTH(5), GGT1(5), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(2), SEPHS1(2)	7181033	37	34	37	21	18	2	12	1	4	0	0.965	1.000	1.000
562	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7)	4626946	35	33	34	14	15	1	8	5	6	0	0.697	1.000	1.000
563	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(6), CHAT(5), CHKA(5), PCYT1A(2), PDHA1(5), PDHA2(6), PEMT(1), SLC18A3(5)	3996273	35	33	35	22	12	2	14	4	3	0	0.983	1.000	1.000
564	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7)	4626946	35	33	34	14	15	1	8	5	6	0	0.697	1.000	1.000
565	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(3), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST8SIA1(3)	6224947	35	33	35	17	15	1	12	3	4	0	0.874	1.000	1.000
566	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(4), IL1B(3), MST1(10), MST1R(16), TNF(4)	3802040	38	33	38	24	16	2	9	3	8	0	0.981	1.000	1.000
567	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(1), GPD2(10), NDUFA1(1), SDHA(9), SDHB(2), SDHC(2), SDHD(4), UQCRC1(2)	3866268	38	32	38	11	18	2	12	2	4	0	0.591	1.000	1.000
568	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(3), GPI(4), HK1(15), PFKL(2), PGAM1(1), PGK1(2), PKLR(8), TPI1(1)	5368723	39	32	39	22	17	1	12	4	5	0	0.946	1.000	1.000
569	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(2), ENO3(4), FARS2(1), GOT1(2), PAH(11), TAT(5), YARS(5)	4853154	33	32	33	12	11	1	5	7	9	0	0.692	1.000	1.000
570	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(5), CCNH(4), CDC25A(5), CDC25B(2), CDC25C(2), CDK7(6), MNAT1(4), SHH(6), XPO1(7)	5052462	41	32	40	16	28	2	5	1	5	0	0.929	1.000	1.000
571	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9)	6104608	34	32	34	16	9	2	9	6	8	0	0.957	1.000	1.000
572	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9)	6104608	34	32	34	16	9	2	9	6	8	0	0.957	1.000	1.000
573	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(3), FYN(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(19), ZAP70(3)	5270758	43	32	43	21	18	0	14	7	4	0	0.955	1.000	1.000
574	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6)	4039204	38	32	36	12	24	0	8	2	4	0	0.737	1.000	1.000
575	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(2), CSF3(1), EPO(2), FLT3(10), IGF1(2), IL1A(1), IL6(4), KITLG(5), TGFB1(3), TGFB3(1)	4762675	31	31	31	11	19	1	7	0	4	0	0.597	1.000	1.000
576	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST8SIA1(3)	5858469	32	31	32	17	12	1	11	3	5	0	0.922	1.000	1.000
577	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(5), FH(7), IDH1(9), IDH2(2), MDH1(3), SDHB(2), SUCLA2(2)	5199412	34	31	34	14	19	2	5	5	3	0	0.820	1.000	1.000
578	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(5), ACAT2(1), BDH2(3), HMGCL(1), HMGCS1(9), HMGCS2(7), OXCT1(4), OXCT2(2)	4204082	32	30	32	12	16	2	6	5	3	0	0.827	1.000	1.000
579	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CSK(7), GRB2(3), PRKCA(3), PTPRA(2), SRC(5)	5374586	34	30	34	24	21	2	9	2	0	0	0.997	1.000	1.000
580	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), CKM(5), EIF4E(2), FBL(2), GPT(2), LDHB(2), LDHC(4), MAPK14(3), NCL(3)	5229814	29	29	29	15	18	2	6	1	2	0	0.953	1.000	1.000
581	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1E(3), PER1(6)	4876676	29	28	29	11	12	0	9	2	6	0	0.864	1.000	1.000
582	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(6), GNAS(12), GNB1(7), PRKACA(2), PRKAR1A(3)	3861208	30	28	29	14	15	3	7	2	3	0	0.887	1.000	1.000
583	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), MIOX(2), UGDH(5)	4923620	31	28	31	12	10	2	7	6	6	0	0.693	1.000	1.000
584	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(2), FOS(4), FYN(7), JUN(4), MAPK14(3), THBS1(8)	4319310	31	28	29	13	14	0	9	4	4	0	0.895	1.000	1.000
585	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HSD3B7(2), PON1(6), PON2(2), PON3(3), RDH12(2), RDH13(1)	5235485	32	27	30	18	11	0	13	2	6	0	0.949	1.000	1.000
586	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6)	3691193	26	26	24	17	13	2	6	1	4	0	0.903	1.000	1.000
587	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6)	3691193	26	26	24	17	13	2	6	1	4	0	0.903	1.000	1.000
588	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(3), FUT2(6), FUT9(3), GCNT2(10), ST8SIA1(3)	3559098	28	25	28	13	11	1	8	5	3	0	0.839	1.000	1.000
589	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASS(11), KARS(11)	2758501	26	25	26	11	19	1	4	1	1	0	0.947	1.000	1.000
590	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(2), CHST12(3), PAPSS1(4), PAPSS2(2), SULT1A1(3), SULT1A2(1), SULT1E1(1), SULT2A1(4), SULT2B1(2), SUOX(3)	5384806	27	25	26	20	16	2	4	4	1	0	0.997	1.000	1.000
591	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1)	4571457	28	25	28	13	14	0	6	5	3	0	0.834	1.000	1.000
592	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CDO1(2), CSAD(3), GAD1(8), GAD2(6), GGT1(5)	3329217	27	24	27	14	11	2	8	2	4	0	0.932	1.000	1.000
593	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(6), PARK2(4), SNCA(1), SNCAIP(8), UBE2E2(1), UBE2F(1), UBE2L3(2), UBE2L6(2)	3754340	25	23	25	10	11	3	3	3	5	0	0.859	1.000	1.000
594	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), GCDH(6), HADHA(4), SDHB(2), SDS(2)	4551112	27	22	27	12	18	1	2	1	5	0	0.910	1.000	1.000
595	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(3), CD3E(2), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL6(4), KITLG(5)	3612454	25	22	25	13	11	2	7	1	4	0	0.920	1.000	1.000
596	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(8), HDC(6), TH(2), TPH1(3)	3446149	23	22	23	12	11	1	6	1	4	0	0.913	1.000	1.000
597	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1)	9685560	27	21	26	12	10	1	11	2	3	0	0.948	1.000	1.000
598	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(7), BMPR1A(3), BMPR1B(5), BMPR2(9)	3642933	24	21	23	10	13	1	3	1	6	0	0.902	1.000	1.000
599	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(5), ALPL(4), ALPP(3), FPGS(4), GCH1(2), GGH(3)	3683789	21	20	21	12	10	0	8	1	2	0	0.845	1.000	1.000
600	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(12), PRKCA(3), PTK2B(6)	3907826	22	20	22	14	11	2	5	2	2	0	0.944	1.000	1.000
601	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(3), CASP8(14), CFL1(1), CFLAR(2)	2251441	20	20	20	10	10	1	2	2	5	0	0.907	1.000	1.000
602	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(4), NR1I3(4), PTGS1(2), PTGS2(6)	3136003	20	19	20	12	9	3	5	2	1	0	0.920	1.000	1.000
603	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(4), COQ5(5), COQ6(7), NDUFA12(1), NDUFA13(3)	2310212	22	19	22	12	13	3	2	1	3	0	0.972	1.000	1.000
604	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(3), GRIA2(7), JUND(2), PPP1R1B(5)	2161565	20	18	20	13	11	0	4	3	2	0	0.988	1.000	1.000
605	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(5), PNPO(2), PSAT1(6)	2831492	21	18	21	10	7	0	2	3	9	0	0.920	1.000	1.000
606	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(3), CD8A(2), CSF1(4), CSF3(1), EPO(2), IL2(1), IL5(1), IL6(4), IL7(1)	3489735	19	18	19	10	11	1	5	2	0	0	0.834	1.000	1.000
607	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(4), GGT1(5), SHMT1(3), SHMT2(2)	3137199	17	16	17	13	5	1	7	1	3	0	0.987	1.000	1.000
608	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(2), CTH(5), MUT(9)	2855059	17	16	17	5	11	1	2	3	0	0	0.620	1.000	1.000
609	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(4), SUOX(3)	3581651	17	16	17	12	9	1	4	2	1	0	0.994	1.000	1.000
610	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(6), BCMO1(3)	2281033	15	15	14	6	9	0	4	2	0	0	0.703	1.000	1.000
611	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(6), PRKCA(3), TGM2(2)	2861448	12	12	12	12	5	0	4	2	1	0	0.995	1.000	1.000
612	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(4), CD3E(2), CD3G(2), CD4(3)	1881739	17	12	17	11	6	1	4	4	2	0	0.948	1.000	1.000
613	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(2), RDH12(2), RDH13(1)	2776382	10	9	10	12	5	2	1	1	1	0	0.997	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(3)	1049299	6	6	6	5	3	2	1	0	0	0	0.957	1.000	1.000
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	960891	1	1	1	2	1	0	0	0	0	0	0.982	1.000	1.000
616	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		421699	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
