rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(3), COPS5(1), EP300(16), HIF1A(4), JUN(2), NOS3(4), P4HB(2), VHL(245)	16864926	279	254	173	19	9	11	30	80	146	3	5.78e-08	1.55e-15	6.84e-13
2	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), FLT1(10), FLT4(14), HIF1A(4), HRAS(1), KDR(6), NOS3(4), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PXN(3), SHC1(4), VHL(245)	34047014	334	280	225	33	20	25	37	95	155	2	3.84e-07	2.89e-15	6.84e-13
3	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), BTRC(2), CDC16(4), CDC20(3), CDC23(2), CDC27(14), CUL1(5), CUL2(4), CUL3(13), FBXW11(2), FBXW7(6), FZR1(4), RBX1(1), SKP2(1), SMURF2(4), TCEB1(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(245), WWP1(8), WWP2(4)	40744239	356	305	248	31	18	24	45	105	162	2	1.09e-08	3.33e-15	6.84e-13
4	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(5), MYC(2), SP1(2), SP3(2), TP53(50), WT1(3)	6959343	66	56	57	4	5	7	5	21	25	3	0.000164	5.44e-15	8.38e-13
5	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(2), EIF2S2(2), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), TP53(50)	10030074	68	57	56	6	6	11	5	17	25	4	0.00132	7.96e-08	9.81e-06
6	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(4), AKT1(3), ATM(20), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIF1A(4), IGFBP3(1), NFKBIB(2), TP53(50)	20275174	97	81	84	6	8	10	10	29	35	5	1.54e-05	3.58e-07	3.68e-05
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(3), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2A(5), CFL1(1), E2F1(1), E2F2(1), PRB1(10), TP53(50)	8179625	84	66	67	11	5	7	8	21	38	5	0.0176	7.89e-07	6.94e-05
8	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(5), AKT3(3), GRB2(2), ILK(4), MAPK3(3), PDK1(1), PIK3CA(14), PIK3CD(2), PTEN(34), PTK2B(3), RBL2(5), SHC1(4), SOS1(9)	20233576	92	80	85	6	7	17	10	24	31	3	3.43e-05	2.42e-06	0.000186
9	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(9), CDKN2A(5), E2F1(1), MYC(2), PIK3CA(14), PIK3R1(5), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), RAC1(1), RB1(4), TP53(50)	19807798	105	87	90	12	8	21	8	33	30	5	0.000272	0.000539	0.0369
10	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(6), CDKN1B(1), GRB2(2), ILK(4), ITGB1(7), MAPK3(3), PDK2(3), PIK3CA(14), PIK3R1(5), PTEN(34), PTK2(3), SHC1(4), SOS1(9)	19180015	98	84	91	13	6	16	9	27	36	4	0.0201	0.00411	0.253
11	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(6)	2164498	18	17	12	3	1	4	1	2	9	1	0.547	0.0101	0.566
12	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(2), FUT1(1), FUT2(2), GCNT2(22), ST8SIA1(2)	5908503	30	29	14	2	3	1	1	6	19	0	0.277	0.0110	0.566
13	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4)	5419468	15	15	14	0	3	2	4	5	0	1	0.00868	0.0476	1.000
14	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(20), BAX(1), CCNE1(3), CDK2(2), CDK4(6), CDKN1A(3), E2F1(1), PCNA(4), RB1(4), TIMP3(4), TP53(50)	18256999	101	70	85	11	8	10	11	24	42	6	0.00296	0.0564	1.000
15	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3E(2), CD3G(2), CD4(10)	3265447	16	15	10	2	1	2	1	3	8	1	0.528	0.0584	1.000
16	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CDK2(2), CDK4(6), CHEK1(1), MYT1(5), RB1(4), TP53(50), WEE1(2)	17821606	95	74	82	13	7	11	12	28	32	5	0.0105	0.0628	1.000
17	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(3), GOT2(2), TAT(2), TYR(5)	4732052	15	15	15	1	2	1	3	4	5	0	0.149	0.0661	1.000
18	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(5), AKT3(3), CDKN1A(3), ELK1(1), GRB2(2), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(8), PIK3CA(14), PIK3CD(2), SHC1(4), SOS1(9)	15871468	57	52	51	6	4	14	6	25	7	1	0.00223	0.0677	1.000
19	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(3), EHHADH(6), HADHA(4)	4888973	15	15	14	1	1	3	4	4	3	0	0.0385	0.0777	1.000
20	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(20), ATR(12), CDC25C(3), CHEK1(1), CHEK2(2), TP53(50)	16160042	88	71	78	11	8	10	10	28	29	3	0.00999	0.0862	1.000
21	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLS(7), OAT(2), PRODH(4)	5565788	16	16	16	1	1	3	5	4	3	0	0.0626	0.0943	1.000
22	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(3), PDXP(2), PSAT1(2)	4789589	15	14	15	1	3	1	1	6	4	0	0.127	0.108	1.000
23	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(4), SHMT1(2), SHMT2(5)	4094910	14	14	14	2	1	1	4	5	3	0	0.253	0.118	1.000
24	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(9), KARS(1)	4802785	15	15	15	2	0	3	3	4	5	0	0.276	0.125	1.000
25	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(8), EGF(5), EGFR(10), GRB2(2), MET(22), PDGFRA(8), PRKCA(2), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(4)	19520947	71	63	65	8	5	13	10	27	16	0	0.00522	0.130	1.000
26	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(7), ITGB2(2), PRF1(1)	8328704	26	24	26	2	2	6	3	10	4	1	0.0199	0.131	1.000
27	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), KARS(1)	7059407	20	20	20	2	0	4	4	6	6	0	0.133	0.133	1.000
28	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), EGFR(10), IGF1R(3), MYC(2), POLR2A(13), PPP2CA(1), PRKCA(2), RB1(4), TEP1(9), TERF1(2), TERT(10), TNKS(6), TP53(50), XRCC5(4)	27945408	119	93	107	18	16	19	11	35	33	5	0.000755	0.136	1.000
29	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(1), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(3), PIK3CA(14), PIK3R1(5), PPP2CA(1), PTEN(34), RPS6KB1(2), TSC1(6), TSC2(13)	27738762	112	100	105	14	7	18	13	31	38	5	0.00241	0.142	1.000
30	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(3), IGF1R(3), INPPL1(4), PDK2(3), PIK3CA(14), PIK3R1(5), PPP2CA(1), PTEN(34), RPS6KB1(2)	19725098	81	72	74	11	5	13	7	20	33	3	0.0184	0.187	1.000
31	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4)	8443021	21	21	20	1	1	4	5	8	3	0	0.0143	0.188	1.000
32	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(2), CD3G(2), CD4(10), CD58(1), CD8A(1), IL3(1), KITLG(2)	6256192	23	20	17	2	1	3	2	6	10	1	0.294	0.193	1.000
33	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(10), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL4(1)	3769144	20	19	14	4	2	4	2	2	9	1	0.553	0.203	1.000
34	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(10), DAXX(6), HRAS(1), PAX3(2), PML(6), RARA(4), RB1(4), SIRT1(6), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(50)	18504901	94	78	85	16	10	13	11	25	30	5	0.0161	0.214	1.000
35	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(6), GLS(7), GOT1(3)	7769460	21	21	21	2	0	4	2	9	6	0	0.148	0.256	1.000
36	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(10), ERBB3(8), NRG1(6), UBE2D1(2)	10301766	31	31	29	4	5	3	4	11	8	0	0.106	0.262	1.000
37	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(2)	2651351	7	7	7	1	1	1	2	0	3	0	0.424	0.275	1.000
38	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(29), RANGAP1(1)	8187800	32	28	26	4	2	7	4	9	10	0	0.0658	0.298	1.000
39	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL3(1)	2792284	10	9	10	2	0	3	2	2	3	0	0.450	0.309	1.000
40	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(7), EGF(5), EGFR(10), HGS(3), RAB5A(1), TFRC(3)	12803255	29	28	27	0	5	1	6	9	8	0	0.00152	0.310	1.000
41	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(2), BHMT(7), CTH(2), DNMT1(25), DNMT3A(16), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), TAT(2)	20594276	74	66	55	10	5	7	13	17	32	0	0.127	0.336	1.000
42	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	513607	1	1	1	1	0	0	0	0	1	0	1.000	0.349	1.000
43	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	1171958	4	3	4	0	0	1	1	1	1	0	0.376	0.351	1.000
44	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(3), RAB3A(2), RAB4A(1), RAB5A(1), RAB6A(1)	4248633	10	10	10	1	1	1	2	3	3	0	0.261	0.352	1.000
45	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), GBA3(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TPO(4), TYR(5)	9594681	28	27	28	4	2	2	10	9	5	0	0.120	0.370	1.000
46	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(3), HADHA(4), SDHB(1)	7839298	19	19	16	1	1	3	4	6	5	0	0.0409	0.377	1.000
47	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), MECR(4), PPT1(1)	8470284	19	18	19	1	2	3	6	7	1	0	0.0185	0.377	1.000
48	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(3), GBA3(3), GGT1(4), SHMT1(2), SHMT2(5)	5522244	21	21	18	4	1	1	4	8	7	0	0.327	0.394	1.000
49	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD3G(2), CD80(1), CD86(3), CTLA4(3), GRB2(2), HLA-DRA(1), HLA-DRB1(6), ICOS(3), ITK(2), LCK(1), PIK3CA(14), PIK3R1(5), PTPN11(2)	12644259	48	46	42	7	4	15	5	13	11	0	0.0598	0.404	1.000
50	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ARPC1B(2), ARPC2(9), CDC42(1), PAK1(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), RAC1(1), WASL(7)	13531502	52	50	41	8	3	12	3	20	14	0	0.0897	0.422	1.000
51	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	726871	1	1	1	1	0	0	1	0	0	0	0.957	0.541	1.000
52	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(2), COQ7(1), NDUFA13(2), NDUFB11(1)	4130964	8	8	8	1	3	1	0	3	1	0	0.334	0.543	1.000
53	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	1538815	3	3	3	1	0	0	0	3	0	0	0.815	0.545	1.000
54	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	1715205	5	5	5	2	1	1	1	2	0	0	0.717	0.555	1.000
55	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(2), CD3G(2), CD4(10), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	11196822	37	33	31	5	3	5	3	12	13	1	0.183	0.556	1.000
56	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(7), CTH(2), DNMT1(25), DNMT3A(16), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1)	17236237	67	60	48	8	3	6	11	15	32	0	0.131	0.560	1.000
57	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), NDUFA1(1), SDHA(9), SDHB(1), SDHD(2), UQCRC1(1)	6536667	18	16	18	3	3	7	3	5	0	0	0.101	0.575	1.000
58	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(2), NFKBIA(2), RB1(4), RELA(6), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(50), USH1C(4), WT1(3)	18234504	90	74	78	17	7	11	8	27	31	6	0.118	0.591	1.000
59	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(3), ITGAL(7), ITGAM(9), ITGB2(2), SELE(6), SELL(2)	10626766	32	32	32	5	3	9	6	8	6	0	0.0562	0.593	1.000
60	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(5), ENO2(2), ENO3(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1)	8346172	23	21	23	3	2	2	6	6	7	0	0.122	0.605	1.000
61	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(2), NTAN1(1), SIRT1(6), SIRT5(1), SIRT7(2), VNN2(1)	11898675	29	27	28	4	3	6	6	6	8	0	0.0501	0.611	1.000
62	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(2), LEP(1), LEPR(5), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(5), PRKAG2(6)	14619347	33	32	30	3	2	6	8	6	11	0	0.00967	0.650	1.000
63	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	10584486	28	25	28	4	3	5	3	11	6	0	0.104	0.651	1.000
64	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(9), ATM(20), ATR(12), CCNA1(8), CCNE1(3), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(1), TGFB2(3), TGFB3(1), TP53(50)	30039333	136	103	118	23	11	16	15	38	50	6	0.0150	0.686	1.000
65	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), DFFB(1), HMGB1(3), HMGB2(3), TOP2A(5), TOP2B(7)	10113287	21	20	21	2	3	3	2	6	6	1	0.181	0.695	1.000
66	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(10), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(2)	5153677	23	22	17	5	1	5	3	2	11	1	0.684	0.701	1.000
67	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(5)	6194918	13	11	13	0	0	2	3	5	3	0	0.0167	0.706	1.000
68	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SDHB(1), SUCLA2(2)	8974879	21	20	18	3	1	3	1	7	9	0	0.210	0.709	1.000
69	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(3), SQLE(1)	4384154	8	8	8	1	1	1	0	4	2	0	0.494	0.710	1.000
70	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(4), CAMKK2(3), SYT1(1)	11606698	24	24	23	2	2	3	4	9	6	0	0.0623	0.713	1.000
71	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(5), EGFR(10), GRB2(2), HRAS(1), MAPK3(3), PTPRB(5), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SPRY1(1), SPRY2(3), SPRY4(10), SRC(4)	25040123	71	61	62	7	5	16	9	19	22	0	0.00455	0.721	1.000
72	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(3)	2260400	4	4	4	1	0	0	1	1	2	0	0.830	0.728	1.000
73	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), IL2RA(2), IL4(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), TOB1(5), TOB2(3)	10680453	26	25	26	4	1	4	6	10	5	0	0.151	0.741	1.000
74	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(3)	3085202	5	5	5	1	0	0	1	4	0	0	0.601	0.757	1.000
75	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(3), GOT2(2), LDHB(2), LDHC(3), MPST(2)	6773580	20	20	18	4	1	0	3	7	9	0	0.644	0.765	1.000
76	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(7), POLG(6), PRPS2(4), RRM1(3)	12380440	29	28	27	3	2	5	2	11	9	0	0.0886	0.768	1.000
77	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(1), GSS(1), NFKB1(2), NOX1(7), RELA(6), TNF(1), XDH(7)	9878723	27	24	22	3	1	3	6	6	10	1	0.193	0.769	1.000
78	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), IDS(2), IDUA(6), LCT(7), NAGLU(2)	14285623	44	37	39	7	7	5	6	17	9	0	0.0740	0.777	1.000
79	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(1), PTK2B(3), SHC1(4), SOS1(9), SRC(4)	8688524	24	22	24	4	1	8	2	8	5	0	0.172	0.777	1.000
80	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(3), AKT2(5), AKT3(3), BAD(1), BTK(1), CDKN2A(5), DAPP1(2), GRB2(2), GSK3A(3), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PIK3CA(14), PPP1R13B(4), PTEN(34), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SOS1(9), SOS2(7), TEC(6), YWHAE(1)	35861360	130	108	118	20	6	23	18	35	44	4	0.00854	0.789	1.000
81	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(3), MTMR6(1), NFS1(2), PHPT1(1), THTPA(1), TPK1(2)	6441584	12	12	12	2	2	2	2	6	0	0	0.290	0.789	1.000
82	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(3), IFNGR2(2), JAK1(7), JAK2(7), STAT1(6)	8316258	25	25	25	5	3	0	3	14	5	0	0.496	0.800	1.000
83	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GCNT2(22), ST3GAL6(1), ST8SIA1(2)	15127214	51	44	34	6	7	4	4	11	25	0	0.177	0.805	1.000
84	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(3), DNMT1(25), MTNR1B(1), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), TBXA2R(4)	10557747	47	44	32	9	3	4	7	11	22	0	0.477	0.807	1.000
85	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(4), PPP1R1B(1)	3691951	7	7	7	2	1	1	1	3	1	0	0.649	0.824	1.000
86	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(2)	6105520	22	20	22	6	4	5	4	7	2	0	0.233	0.826	1.000
87	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(8), ZAP70(1)	8778121	33	30	27	6	1	6	2	10	13	1	0.474	0.832	1.000
88	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1)	10131170	19	17	19	2	2	3	3	5	6	0	0.134	0.834	1.000
89	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(1)	3294606	5	5	5	1	0	1	0	2	2	0	0.743	0.835	1.000
90	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), RDH11(4), RDH13(1)	4715015	9	9	9	2	2	0	1	6	0	0	0.496	0.839	1.000
91	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELE(6), SELL(2)	12218157	33	32	33	6	2	9	7	8	7	0	0.131	0.848	1.000
92	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(3), ALDOB(3), ALDOC(1), TPI1(2)	3865278	9	9	9	5	0	0	3	1	5	0	0.982	0.848	1.000
93	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(8), CCNE1(3), CCNE2(4), CDK2(2), CDK4(6), CDKN1B(1), CDKN2A(5), E2F1(1), E2F2(1), PRB1(10)	8842785	41	32	29	9	1	4	4	7	24	1	0.668	0.854	1.000
94	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	2032463	2	2	2	1	0	0	0	1	1	0	0.774	0.872	1.000
95	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(3), UGDH(1), UXS1(1)	3998272	7	7	7	2	0	1	3	3	0	0	0.598	0.874	1.000
96	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(22), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3), PRKCE(4)	18075505	49	46	46	7	6	3	3	21	15	1	0.0990	0.876	1.000
97	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(2), FGG(6), PLAT(4), PLAU(5), PLG(8), SERPINB2(1)	13504810	45	42	40	9	6	4	5	19	11	0	0.220	0.882	1.000
98	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(3), WEE1(2)	7392778	11	10	11	1	0	2	0	5	3	1	0.314	0.883	1.000
99	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(1), CASP9(2), CHUK(2), GHR(1), NFKB1(2), NFKBIA(2), PIK3CA(14), PIK3R1(5), PPP2CA(1), RELA(6)	14209985	39	39	31	6	2	12	3	12	9	1	0.0817	0.890	1.000
100	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SLC2A4(3), SOS1(9), SRF(1)	24921860	74	69	67	11	8	19	8	25	14	0	0.0113	0.896	1.000
101	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(7), MMP9(1), RECK(1), TIMP2(1), TIMP3(4)	7482415	16	15	13	3	2	3	1	3	7	0	0.452	0.902	1.000
102	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(4), HSD17B1(1), HSD17B2(1), HSD17B4(2), HSD17B7(1), HSD3B1(1)	8078703	13	12	13	2	2	3	3	4	1	0	0.209	0.906	1.000
103	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(3), HTR2C(1), PLCB1(4), TUB(4)	7113832	14	13	14	2	1	2	0	10	1	0	0.283	0.906	1.000
104	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(1), CDC25B(1), CDC25C(3), MNAT1(1), SHH(3), XPO1(8)	8685207	19	19	19	4	1	2	7	7	2	0	0.275	0.912	1.000
105	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(3), UGDH(1), UGP2(1), UXS1(1)	5057310	8	8	8	2	0	1	4	3	0	0	0.496	0.913	1.000
106	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1643608	1	1	1	0	0	0	0	1	0	0	0.838	0.915	1.000
107	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3)	3068084	3	3	3	1	0	1	0	2	0	0	0.830	0.916	1.000
108	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(20), ATR(12), BRCA1(9), CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CDKN1A(3), CHEK1(1), CHEK2(2), EP300(16), MYT1(5), PRKDC(13), RPS6KA1(8), TP53(50), WEE1(2)	43039212	147	114	129	21	9	18	17	53	45	5	0.00231	0.918	1.000
109	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(1)	8675384	20	19	19	4	2	2	4	2	8	2	0.461	0.919	1.000
110	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(6), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HSD17B7(1), IDI1(1), IDI2(3), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1), TM7SF2(3), VKORC1(1)	19285921	38	35	36	2	2	6	2	17	11	0	0.0124	0.922	1.000
111	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), CASP7(1), CASP9(2), PRKCA(2), PTK2(3), PXN(3), STAT1(6), TLN1(14), TP53(50)	27491791	111	90	101	19	11	13	12	37	35	3	0.0185	0.929	1.000
112	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(2), FDPS(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), SC5DL(1), SQLE(1), VKORC1(1)	11094202	17	17	17	1	0	3	2	8	4	0	0.0993	0.930	1.000
113	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(5), GPRC5A(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM7(5), GRM8(4)	19738245	55	48	52	9	9	9	5	20	12	0	0.0552	0.933	1.000
114	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1)	7042130	24	24	23	7	0	1	3	11	9	0	0.808	0.942	1.000
115	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5)	5259683	13	13	13	4	2	1	2	4	3	1	0.702	0.944	1.000
116	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), FH(2), IDH2(6), MDH1(2), OGDH(8), SDHA(9), SUCLA2(2)	9450965	31	28	28	7	1	9	0	11	10	0	0.329	0.944	1.000
117	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(10), CD8A(1), IL3(1), IL4(1), IL9(1)	6013784	14	14	8	3	0	2	2	2	7	1	0.828	0.944	1.000
118	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCS1(2), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1)	13226697	23	20	23	1	0	5	2	9	7	0	0.0407	0.945	1.000
119	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(4), ABCB4(8), ABCC1(10), ABCC3(11), GSTP1(2)	14599913	39	32	33	6	2	7	8	10	12	0	0.0996	0.945	1.000
120	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2N(3), UBE3A(2)	10471665	19	19	19	3	1	2	2	9	5	0	0.296	0.945	1.000
121	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(4), APEX1(2), CREBBP(10), DFFA(1), DFFB(1), HMGB2(3), PRF1(1)	10462724	22	21	22	4	4	4	5	3	6	0	0.110	0.951	1.000
122	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), SELE(6), SELL(2), SELP(2)	16189587	44	42	44	9	3	11	9	12	9	0	0.144	0.952	1.000
123	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCNE1(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK3(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3CA(14), PIK3R1(5), RAC1(1), RAF1(4), RB1(4), RELA(6)	20238027	65	56	54	11	5	12	7	18	19	4	0.158	0.955	1.000
124	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(1), ACADS(3), ACSL1(4), ACSL3(13), ACSL4(1), CPT1A(2), CPT2(2), EHHADH(6), HADHA(4), PECR(4), SCP2(3)	16853828	46	42	34	9	2	9	7	21	6	1	0.0920	0.957	1.000
125	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4), STX1A(1), VAMP2(1)	3211172	8	7	8	4	0	1	0	4	3	0	0.913	0.957	1.000
126	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3)	17543882	46	43	45	7	6	4	8	18	10	0	0.0919	0.958	1.000
127	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), CAMP(1), DAG1(3), ITPKA(2), ITPKB(2)	5726775	11	10	11	3	2	1	2	1	5	0	0.736	0.961	1.000
128	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(8), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	15076622	40	38	40	8	5	6	3	16	10	0	0.260	0.966	1.000
129	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(3), GAD1(2), GAD2(2), GGT1(4)	5683713	13	13	13	4	2	2	5	2	2	0	0.505	0.967	1.000
130	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(6), ITGB1(7), KLRC1(3), KLRC2(5), KLRC3(1), LAT(1), MAPK3(3), PAK1(3), PIK3CA(14), PIK3R1(5), PTK2B(3), PTPN6(3), RAC1(1), SYK(2), VAV1(4)	18711135	64	56	58	11	3	15	8	19	18	1	0.109	0.967	1.000
131	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(3), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(2), NOS3(4), NPPA(1), NR3C1(4), PIK3CA(14), PIK3R1(5), RELA(6), SYT1(1)	17724491	52	50	44	9	5	14	5	18	9	1	0.123	0.968	1.000
132	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(1), FUT2(2), FUT3(2), FUT6(4), ST3GAL3(3)	4672695	13	12	11	4	5	1	0	3	4	0	0.692	0.968	1.000
133	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	15126373	42	40	39	7	5	3	2	18	14	0	0.179	0.968	1.000
134	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(1), DHRSX(5), PON2(2), PON3(5), RDH11(4), RDH13(1)	8884385	21	20	16	4	3	0	3	7	8	0	0.601	0.969	1.000
135	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(7), MST1R(4), TNF(1)	6032580	14	14	12	4	1	1	5	2	5	0	0.756	0.970	1.000
136	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG7(6), BECN1(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(1), PRKAA2(4), ULK1(2), ULK2(3), ULK3(3)	21182040	49	46	46	7	4	4	4	24	13	0	0.109	0.971	1.000
137	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), BCMO1(1), RDH5(4)	3854221	7	7	7	3	0	0	5	1	1	0	0.790	0.972	1.000
138	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(2), CYP17A1(3), HSD11B2(1), HSD3B1(1)	6759353	11	9	11	2	1	0	1	9	0	0	0.380	0.973	1.000
139	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), IL9(1), KITLG(2), TGFB2(3), TGFB3(1)	8353125	15	15	15	3	0	1	3	7	4	0	0.583	0.973	1.000
140	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(7), GLS2(4), GLUD2(7)	4425638	18	18	16	5	1	2	3	10	2	0	0.611	0.973	1.000
141	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4)	17550099	42	37	40	7	3	6	11	10	12	0	0.114	0.975	1.000
142	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), KERA(1), LUM(1)	3580606	8	8	8	3	0	1	0	5	2	0	0.790	0.976	1.000
143	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(5), MAPK14(1), MAPK3(3), MKNK1(2), PABPC1(18), PDK2(3), PIK3CA(14), PIK3R1(5), PRKCA(2), PTEN(34), RPS6KB1(2)	27947935	117	100	110	22	10	22	14	32	34	5	0.0530	0.978	1.000
144	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(3), IFNB1(3), JAK1(7), STAT1(6), STAT2(6), TYK2(7)	10778339	34	29	33	8	4	7	4	9	10	0	0.241	0.979	1.000
145	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	8049816	14	14	14	4	0	4	4	4	2	0	0.529	0.982	1.000
146	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1), OXCT1(2)	3424685	4	4	4	2	0	1	0	2	1	0	0.869	0.983	1.000
147	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(8), CCNE1(3), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(1)	8733824	24	23	21	5	2	3	4	3	10	2	0.389	0.984	1.000
148	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TKTL1(2), TKTL2(6), TPI1(2)	19919703	47	46	47	8	2	5	8	15	17	0	0.190	0.986	1.000
149	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(13), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	12685957	36	35	35	8	10	2	4	14	6	0	0.209	0.987	1.000
150	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(6), ELOVL6(1), FADS1(1), FADS2(2), FASN(9), HADHA(4), PECR(4)	14167301	38	32	35	6	4	8	4	16	6	0	0.0449	0.987	1.000
151	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5)	13160936	36	35	33	7	4	5	6	10	11	0	0.209	0.987	1.000
152	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1)	17532361	46	38	33	7	4	5	2	22	13	0	0.134	0.988	1.000
153	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TPI1(2)	17800341	41	39	41	7	2	5	8	10	16	0	0.199	0.988	1.000
154	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNGR1(3), JAK1(7), JAK2(7), PTPRU(5), STAT1(6)	11401408	30	28	30	6	4	0	3	18	5	0	0.421	0.989	1.000
155	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(3), IL10RA(4), JAK1(7), STAT1(6), STAT3(3), STAT5A(3), TNF(1)	12086486	28	28	27	5	4	0	1	13	10	0	0.587	0.989	1.000
156	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(5), GNB1(3), PRKACA(2), PRKAR1A(2)	6330917	14	14	14	4	2	1	1	9	1	0	0.732	0.989	1.000
157	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDK2(2), CUL1(5), E2F1(1), FBXW7(6), RB1(4)	8487807	21	20	21	5	2	3	5	2	7	2	0.503	0.990	1.000
158	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(4), NOS3(4), REN(1)	9667579	25	24	23	5	2	4	3	10	6	0	0.298	0.990	1.000
159	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11705473	30	29	30	6	2	3	9	10	6	0	0.264	0.991	1.000
160	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), MASP1(4), MASP2(1), MBL2(2)	21400601	53	45	40	8	6	6	3	24	14	0	0.0794	0.991	1.000
161	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CCL2(1), LDLR(3), LPL(3)	5223024	8	8	8	3	0	3	0	4	1	0	0.679	0.992	1.000
162	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(20), ATR(12), BAI1(6), BAX(1), BBC3(1), BID(2), CASP8(1), CASP9(2), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNG1(1), CCNG2(2), CD82(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN2A(5), CHEK1(1), CHEK2(2), FAS(2), GADD45B(1), GTSE1(4), IGFBP3(1), LRDD(1), PERP(1), PPM1D(2), PTEN(34), RCHY1(3), RFWD2(3), RRM2(1), SERPINB5(5), SESN1(2), SFN(1), STEAP3(2), THBS1(15), TNFRSF10B(1), TP53(50), TP53I3(6), TP73(4), TSC2(13), ZMAT3(1)	64756424	248	178	230	35	24	33	34	61	89	7	1.73e-05	0.992	1.000
163	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(4), F2R(2), F5(12), F7(1), FGA(4), FGB(2), FGG(6), PROC(4), PROS1(5), TFPI(2)	16338029	43	41	41	9	5	5	3	16	13	1	0.360	0.993	1.000
164	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(1), CHRNB1(4), MUSK(4), PIK3CA(14), PIK3R1(5), PTK2(3), PTK2B(3), RAPSN(1), SRC(4), TERT(10)	16372374	52	49	47	10	5	18	4	18	7	0	0.0617	0.994	1.000
165	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(3), CTSD(3), GREB1(18), HSPB2(2), MTA1(4), MTA3(3), PDZK1(1)	10599857	34	31	31	8	1	2	7	17	7	0	0.605	0.994	1.000
166	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), GCDH(3), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(11), SHMT1(2), SHMT2(5), TMLHE(1)	35905827	104	87	92	17	8	16	14	34	31	1	0.0290	0.994	1.000
167	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(5), AOC3(2), CES1(8), ESD(1)	5734455	21	20	19	6	0	3	4	9	5	0	0.553	0.994	1.000
168	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(6), C6(3), C7(4), C8A(1)	12856880	22	21	22	4	2	2	2	12	4	0	0.327	0.994	1.000
169	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(3), EPOR(3), GRIN1(2), HIF1A(4), JAK2(7), NFKB1(2), NFKBIA(2), RELA(6)	12667776	31	29	28	6	1	4	4	10	9	3	0.360	0.994	1.000
170	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(11), NRG2(4), NRG3(5), PRKCA(2)	9122312	24	24	24	6	3	5	3	10	3	0	0.421	0.995	1.000
171	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4)	12143248	30	30	27	7	2	5	7	10	6	0	0.337	0.996	1.000
172	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(3), GBA3(3), LPO(1), MPO(6), PRDX6(2), TPO(4)	8274972	22	21	22	5	2	2	7	8	3	0	0.336	0.996	1.000
173	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(5), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(2)	6617312	13	13	11	4	1	2	1	3	6	0	0.801	0.996	1.000
174	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(2), MUT(2)	4850611	5	5	5	2	1	0	1	1	2	0	0.890	0.996	1.000
175	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1), YARS2(1)	8708104	17	17	17	4	1	1	4	5	6	0	0.607	0.996	1.000
176	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(4), SP1(2), SP3(2)	6742291	11	11	11	3	0	3	0	2	4	2	0.835	0.996	1.000
177	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(3), JAK1(7), PTPRU(5), STAT1(6), STAT2(6), TYK2(7)	12301259	37	32	36	9	5	5	4	13	10	0	0.299	0.996	1.000
178	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), C8B(2), MASP1(4)	20846979	52	44	39	8	7	5	2	24	14	0	0.101	0.996	1.000
179	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(1), CASP9(2), CDC42(1), CHUK(2), ELK1(1), HRAS(1), MAPK3(3), NFKB1(2), PIK3CA(14), PIK3R1(5), RAC1(1), RAF1(4), RALA(2), RALBP1(2), RELA(6)	19189432	50	49	41	9	2	13	5	17	12	1	0.161	0.997	1.000
180	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SRP19(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1)	7594500	11	10	11	3	1	3	2	5	0	0	0.504	0.997	1.000
181	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1)	23473829	54	50	50	8	5	7	4	24	14	0	0.0735	0.997	1.000
182	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ARPC1B(2), ARPC2(9), CDC42(1), RAC1(1), WASF1(1), WASL(7)	8131288	24	24	18	6	1	5	0	11	7	0	0.526	0.997	1.000
183	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	17963465	33	32	33	5	3	6	3	15	6	0	0.110	0.997	1.000
184	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(10), HLA-DRA(1), HLA-DRB1(6), IFNA1(2), IFNB1(3), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(3), TGFB3(1), TNF(1)	12968985	31	29	25	6	0	9	3	8	10	1	0.361	0.997	1.000
185	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(15)	7214724	22	20	19	7	1	2	5	7	7	0	0.864	0.997	1.000
186	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(2), HDC(1), TH(4), TPH1(2)	5828899	11	11	11	4	2	2	3	2	2	0	0.692	0.998	1.000
187	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	3849704	3	3	3	2	0	0	2	0	1	0	0.942	0.998	1.000
188	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(5), GPI(3), HK1(5), PFKL(3), PGAM1(1), PGK1(3), PKLR(1), TPI1(2)	9044318	26	24	24	8	4	3	3	7	9	0	0.574	0.998	1.000
189	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(2), FUT3(2), ST3GAL3(3), ST3GAL4(2)	6991590	18	17	16	6	6	0	2	3	7	0	0.769	0.998	1.000
190	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(3), IFNB1(3), NFKB1(2), RELA(6), TRAF6(2)	10827165	18	18	15	4	2	6	0	2	7	1	0.502	0.998	1.000
191	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7)	10359495	27	26	26	8	3	0	5	9	10	0	0.714	0.998	1.000
192	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7)	10359495	27	26	26	8	3	0	5	9	10	0	0.714	0.998	1.000
193	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), GSR(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6), OPLAH(7), TXNDC12(1)	21902956	62	54	59	11	5	7	13	24	13	0	0.103	0.998	1.000
194	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1)	8480260	19	19	17	5	1	3	4	5	6	0	0.647	0.998	1.000
195	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(5), WEE1(2)	13884133	33	30	32	7	2	4	5	14	8	0	0.324	0.999	1.000
196	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), E2F1(1), RB1(4)	15905308	39	34	33	9	2	4	4	8	18	3	0.543	0.999	1.000
197	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(3), DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), KLK2(1), MAPK3(3), NGFR(1), PIK3CA(14), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(4), SOS1(9)	18750835	56	53	50	11	5	14	6	21	10	0	0.139	0.999	1.000
198	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	12849668	26	26	26	6	3	3	3	13	4	0	0.350	0.999	1.000
199	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), DHRSX(5), PON2(2), PON3(5)	17674096	43	41	37	9	4	7	4	14	14	0	0.307	0.999	1.000
200	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), NAGLU(2), SPAM1(8)	20450039	65	54	60	13	11	8	8	27	11	0	0.0742	0.999	1.000
201	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), GNA12(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3)	10017406	24	24	24	6	3	3	3	11	4	0	0.461	0.999	1.000
202	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(7), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(5), SOAT1(4)	13744220	37	32	35	8	2	3	8	14	10	0	0.329	0.999	1.000
203	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(4), ENPP3(2), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(7), NT5M(2), QPRT(1)	14586679	29	28	29	6	2	2	3	17	5	0	0.355	0.999	1.000
204	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(3), HDAC9(4), MEF2A(3), MEF2D(1)	8146447	14	14	13	4	2	1	2	3	6	0	0.590	0.999	1.000
205	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3)	5684384	11	11	10	6	1	0	0	8	2	0	0.972	0.999	1.000
206	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), EGF(5), EGFR(10), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3)	37411664	105	91	96	17	10	20	10	35	30	0	0.0375	0.999	1.000
207	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(10), HRAS(1), KLK2(1), MAP2K2(1), MAPK3(3), NGFR(1), RAF1(4)	8043076	22	22	15	6	2	1	2	8	9	0	0.827	0.999	1.000
208	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	13478748	26	26	26	6	3	3	3	13	4	0	0.349	0.999	1.000
209	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(8)	11734006	25	25	25	6	2	4	5	6	8	0	0.453	1.000	1.000
210	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(5), ACSS1(4), ACSS2(7), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SUCLA2(2)	13350534	37	31	33	9	1	6	3	11	15	1	0.556	1.000	1.000
211	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFKB1(2), PIK3CA(14), PIK3R1(5), RB1(4), RELA(6), SP1(2)	19684038	54	52	46	10	3	14	3	20	11	3	0.221	1.000	1.000
212	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), NDST1(2), NDST2(4), NDST3(1), NDST4(7)	20326473	48	44	42	8	5	4	7	17	15	0	0.133	1.000	1.000
213	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(1), FURIN(3), NOTCH1(12)	8454303	18	18	16	5	3	4	0	5	5	1	0.573	1.000	1.000
214	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RELA(6)	8271451	16	16	13	6	2	3	0	4	6	1	0.877	1.000	1.000
215	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRKL(1), DOCK1(3), ELK1(1), FOS(1), GAB1(2), GRB2(2), HGF(1), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAP4K1(5), MAPK3(3), MET(22), PAK1(3), PIK3CA(14), PIK3R1(5), PTEN(34), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAF1(4), RAP1A(1), RASA1(7), SOS1(9), SRC(4), STAT3(3)	45046157	156	125	146	28	7	31	17	49	49	3	0.0324	1.000	1.000
216	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), BAX(1), BCL10(1), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8)	11444024	27	27	25	7	1	2	4	9	11	0	0.658	1.000	1.000
217	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(2), IL4(1), IL4R(4), IRS1(5), JAK1(7), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(5)	14280336	37	35	37	9	6	3	5	14	9	0	0.381	1.000	1.000
218	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11498705	27	26	27	6	2	3	6	10	6	0	0.379	1.000	1.000
219	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(9), ATM(20), BRCA1(9), CDKN1A(3), CHEK1(1), CHEK2(2), JUN(2), MRE11A(3), NFKB1(2), NFKBIA(2), RAD50(4), RAD51(2), RBBP8(2), RELA(6), TP53(50), TP73(4)	29563356	121	97	108	23	13	15	12	41	35	5	0.0634	1.000	1.000
220	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13)	16460708	35	32	33	5	3	1	2	14	15	0	0.337	1.000	1.000
221	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2)	13783530	32	30	32	8	3	3	4	13	9	0	0.493	1.000	1.000
222	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CSK(4), GRB2(2), PRKCA(2), PTPRA(5), SRC(4)	9194770	23	21	23	6	0	8	4	8	3	0	0.353	1.000	1.000
223	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(2), GPR171(1), GPR18(2), GPR39(2), GPR45(3), GPR65(5), GPR75(1)	9703900	17	17	17	5	3	4	0	7	2	1	0.309	1.000	1.000
224	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(2)	4863301	5	5	5	3	0	1	0	2	2	0	0.962	1.000	1.000
225	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(5), AKT3(3), BAD(1), GRB2(2), GSK3A(3), GSK3B(3), IL4R(4), IRS1(5), JAK1(7), JAK3(4), MAP4K1(5), MAPK3(3), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), STAT6(5)	35073374	103	88	96	18	12	18	19	35	19	0	0.00884	1.000	1.000
226	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(3), ALOX5(4), DPEP1(1), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	15047940	37	34	34	9	4	5	9	10	8	1	0.314	1.000	1.000
227	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	8538360	17	17	17	5	1	1	1	8	6	0	0.804	1.000	1.000
228	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(4), SULT1E1(2), SULT2A1(1), SUOX(4)	6145351	14	14	14	5	1	2	5	3	3	0	0.674	1.000	1.000
229	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	7686861	14	14	13	8	2	0	2	4	6	0	0.973	1.000	1.000
230	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(4)	12513657	30	28	30	9	5	4	2	11	8	0	0.585	1.000	1.000
231	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(2), MDH1(2), ME1(1), PC(8), PDHA1(1), SLC25A1(1), SLC25A11(1)	9156149	22	21	22	9	1	3	1	10	7	0	0.885	1.000	1.000
232	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(2), CD3G(2), CD4(10), IL12RB1(4), IL12RB2(2), JAK2(7), STAT4(2), TYK2(7)	14775786	39	36	32	8	3	2	6	12	15	1	0.609	1.000	1.000
233	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3)	16429456	22	21	18	3	1	2	4	7	8	0	0.331	1.000	1.000
234	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(3), CSNK1A1(2), GSK3B(3), MAPT(4), PPP2CA(1)	9382975	14	13	12	8	0	1	2	2	9	0	0.987	1.000	1.000
235	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CTH(2), GGT1(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1)	12160401	31	30	31	9	3	5	8	8	7	0	0.474	1.000	1.000
236	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ENPP1(4), ENPP3(2), FLAD1(4), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5)	15026149	29	28	28	6	0	6	1	18	4	0	0.391	1.000	1.000
237	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
238	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
239	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
240	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), PER1(6)	8447097	17	17	16	5	2	1	4	5	4	1	0.658	1.000	1.000
241	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC2(5), AOC3(2), CES1(8), DDHD1(2), ESCO1(2), ESCO2(1), LIPA(1), MYST3(4), MYST4(3), PLA1A(3), PNPLA3(3), PRDX6(2), SH3GLB1(3)	25070993	45	40	43	6	2	5	7	18	13	0	0.0870	1.000	1.000
242	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(3), NR3C1(4), PPARG(2), RETN(1), TNF(1)	5591626	11	11	11	5	1	3	2	3	2	0	0.812	1.000	1.000
243	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(4), SREBF1(4), SREBF2(8)	17987606	38	37	38	8	1	7	7	13	10	0	0.277	1.000	1.000
244	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(2), CRKL(1), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(2), PIK3CA(14), PIK3R1(5), RAF1(4), SOS1(9), STAT1(6), STAT5A(3), STAT5B(3)	27642790	76	70	70	14	5	14	9	33	15	0	0.0916	1.000	1.000
245	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(3), MAF(2), MAP2K3(4), MAPK14(1), NFATC1(4), NFATC2(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	11365863	39	37	37	11	8	0	2	19	10	0	0.587	1.000	1.000
246	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(3)	6689394	11	11	10	7	1	3	1	2	4	0	0.973	1.000	1.000
247	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), THPO(1)	29869878	84	74	77	15	7	16	10	31	20	0	0.0888	1.000	1.000
248	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(1), HDAC5(3), MEF2A(3), MEF2D(1), PPP3CA(3), PPP3CC(3), SLC2A4(3), SYT1(1)	20534709	34	34	33	5	4	2	4	13	11	0	0.150	1.000	1.000
249	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR1H3(3), NR1H4(2)	5216943	8	8	8	5	0	3	0	4	1	0	0.886	1.000	1.000
250	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(2), HRAS(1), MAPK3(3), MAPK7(4), MEF2A(3), MEF2D(1), NTRK1(8), PIK3CA(14), PIK3R1(5), PLCG1(4), RPS6KA1(8), SHC1(4)	19052878	60	55	47	13	6	11	7	23	12	1	0.245	1.000	1.000
251	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(2), NFKB1(2), PLCG1(4), PRKCA(2), RELA(6)	20353047	47	41	41	9	5	5	5	18	13	1	0.325	1.000	1.000
252	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST8SIA1(2)	10462880	18	17	18	5	5	3	2	7	1	0	0.337	1.000	1.000
253	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(9), GNAS(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1)	12776536	33	33	33	9	4	2	2	17	8	0	0.725	1.000	1.000
254	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3)	34875916	98	86	91	17	9	19	8	35	27	0	0.0550	1.000	1.000
255	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(2), FTCD(2), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	19046794	36	35	36	8	3	6	3	18	6	0	0.360	1.000	1.000
256	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(2), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT1E1(2), SULT2A1(1), SUOX(4)	8895794	19	19	18	6	3	3	5	3	5	0	0.633	1.000	1.000
257	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(5), AKT3(3), BRAF(4), DDIT4(1), EIF4B(5), EIF4EBP1(1), FIGF(2), HIF1A(4), INS(1), MAPK3(3), PGF(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRKAA1(1), PRKAA2(4), RHEB(5), RICTOR(7), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(3), TSC1(6), TSC2(13), ULK1(2), ULK2(3), ULK3(3), VEGFC(2)	52905862	136	123	117	23	13	25	19	45	29	5	0.00475	1.000	1.000
258	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(2), MAPK14(1), NFKB1(2), RELA(6), TNFRSF13B(1), TNFRSF17(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	14523652	25	24	22	5	0	6	0	8	10	1	0.590	1.000	1.000
259	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(6), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(6)	24821920	55	51	55	11	6	7	8	25	9	0	0.164	1.000	1.000
260	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(10), ELK1(1), GNAS(5), GNB1(3), GRB2(2), HRAS(1), IGF1R(3), ITGB1(7), KLK2(1), MAP2K2(1), MAPK3(3), MKNK1(2), MKNK2(1), MYC(2), NGFR(1), PDGFRA(8), PPP2CA(1), PTPRR(5), RAF1(4), RPS6KA1(8), RPS6KA5(2), SHC1(4), SOS1(9), SRC(4), STAT3(3)	32793720	92	78	85	18	9	14	9	36	23	1	0.142	1.000	1.000
261	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR7(1), CD28(1), CD4(10), CXCR4(1), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL4(1), IL4R(4), TGFB2(3), TGFB3(1)	20042506	40	38	34	8	5	2	4	15	13	1	0.389	1.000	1.000
262	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2), P2RY6(2)	5565472	15	14	15	6	3	2	2	7	1	0	0.580	1.000	1.000
263	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP1(4), ENPP3(2), FLAD1(4), TYR(5)	9661735	19	18	19	5	0	4	0	11	4	0	0.646	1.000	1.000
264	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	15	14	15	7	1	0	2	8	4	0	0.838	1.000	1.000
265	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	15	14	15	7	1	0	2	8	4	0	0.838	1.000	1.000
266	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(1), EPOR(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(4), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3)	21357045	53	50	51	10	4	6	11	19	13	0	0.194	1.000	1.000
267	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(2), SNCAIP(4), UBE2E2(1), UBE2L3(1)	6336035	11	11	11	5	1	4	1	3	2	0	0.749	1.000	1.000
268	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF8(2)	13133143	25	24	23	6	2	7	3	5	8	0	0.371	1.000	1.000
269	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2)	25781060	45	41	38	6	2	5	8	13	17	0	0.138	1.000	1.000
270	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(1), OXCT1(2)	7281201	9	9	9	4	0	2	1	5	1	0	0.859	1.000	1.000
271	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(3), MPST(2), SULT1B1(2), SULT1C2(1), SULT1C4(3), SULT4A1(1)	12512961	31	31	29	8	2	1	5	12	11	0	0.760	1.000	1.000
272	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ARPC1B(2), ARPC2(9), NCK1(1), NCKAP1(3), NTRK1(8), PIR(1), PSMA7(1), RAC1(1), WASF1(1), WASF2(2), WASF3(3), WASL(7)	15201316	42	38	35	10	2	7	2	20	11	0	0.415	1.000	1.000
273	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(1), BRAF(4), CREB3(2), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(4), EIF4E(2), GRB2(2), MAP2K2(1), MAP3K8(1), MAPK3(3), MKNK1(2), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA1(8), RPS6KA3(3), SHC1(4), SOS1(9), SOS2(7), TRAF3(1)	29505379	69	64	64	13	7	11	15	21	13	2	0.0684	1.000	1.000
274	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), FDXR(2), SHMT1(2)	16061007	35	33	35	9	2	4	8	14	6	1	0.449	1.000	1.000
275	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), NAT1(1), NAT2(2), XDH(7)	7901121	25	24	25	8	4	3	4	10	4	0	0.648	1.000	1.000
276	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3)	7932985	17	17	15	6	1	2	4	6	4	0	0.821	1.000	1.000
277	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3)	7932985	17	17	15	6	1	2	4	6	4	0	0.821	1.000	1.000
278	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPX1(2), PRKCE(4)	7712784	15	15	15	9	0	1	3	9	2	0	0.978	1.000	1.000
279	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(6), ARHGDIB(1), CASP1(3), CASP10(4), CASP8(1), CASP9(2), JUN(2), PRF1(1)	12699345	23	22	23	6	0	4	2	9	8	0	0.710	1.000	1.000
280	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(3), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), CHST1(2), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	11591238	26	25	25	9	4	4	2	6	10	0	0.749	1.000	1.000
281	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	22322459	69	60	63	15	6	10	5	28	19	1	0.357	1.000	1.000
282	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	22322459	69	60	63	15	6	10	5	28	19	1	0.357	1.000	1.000
283	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST8SIA1(2)	5420228	11	11	11	6	1	2	1	6	1	0	0.798	1.000	1.000
284	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	4	1	0	0.806	1.000	1.000
285	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	4	1	0	0.806	1.000	1.000
286	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(3), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), CAD(13), CRAT(3), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), PC(8)	25927610	61	54	57	11	2	7	11	14	26	1	0.232	1.000	1.000
287	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), ATF3(1), EIF4E(2), EIF4EBP1(1), IFRD1(1), IL1R1(3), NR4A3(2), WDR1(2)	10856714	17	17	17	5	1	4	4	5	3	0	0.570	1.000	1.000
288	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2C1(5), MANBA(2), NEU1(1)	16037207	28	27	28	7	4	4	3	13	4	0	0.432	1.000	1.000
289	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(3), RPN2(1), UBE2A(2), UBE3A(2)	13232474	24	24	24	7	1	2	2	11	8	0	0.756	1.000	1.000
290	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(8)	9349842	21	21	21	6	5	1	4	7	4	0	0.676	1.000	1.000
291	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), PC(8), PCK1(5), SDHA(9), SDHB(1), SUCLA2(2), SUCLG1(5), SUCLG2(2)	20569521	61	54	58	15	3	10	7	22	18	1	0.368	1.000	1.000
292	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(3), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(1), PCYT1B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	13882855	25	23	25	6	1	2	4	9	9	0	0.580	1.000	1.000
293	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), RAF1(4), SNX13(4), SRC(4)	11545453	27	23	27	8	2	6	6	9	3	1	0.534	1.000	1.000
294	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(3), MYC(2), NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RAF1(4), RELA(6), TNF(1)	15171285	32	31	29	8	6	3	2	11	9	1	0.561	1.000	1.000
295	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(6), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF5(3), GSK3B(3), PPP1CA(1)	11555478	22	21	20	8	2	1	5	6	8	0	0.816	1.000	1.000
296	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), JUN(2), KEAP1(3), MAPK14(1), NFE2L2(11), PRKCA(2)	8751422	20	20	18	8	1	3	3	10	3	0	0.808	1.000	1.000
297	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(5), GNB1(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2)	9484817	27	26	27	8	4	3	0	15	5	0	0.723	1.000	1.000
298	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	14720858	26	24	22	5	1	2	5	6	12	0	0.479	1.000	1.000
299	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(2), MAOA(2), MAOB(2), PRPS1(1), PRPS2(4)	24203280	59	55	56	13	6	10	10	22	11	0	0.153	1.000	1.000
300	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(2), IFNB1(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TGFB2(3), TGFB3(1), TNF(1), TRAF6(2)	29600469	64	58	60	11	8	15	1	21	17	2	0.0982	1.000	1.000
301	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(4), FYN(2), ITGA1(8), ITGB1(7), L1CAM(5), LYN(1), SELP(2)	15696413	32	30	30	9	4	5	2	13	8	0	0.621	1.000	1.000
302	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(5), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HIBCH(1), MLYCD(3), SMS(2), UPB1(2)	26665905	69	63	66	16	4	9	17	21	17	1	0.191	1.000	1.000
303	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	7316523	15	14	15	8	3	0	5	6	1	0	0.913	1.000	1.000
304	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(20), BMPR1B(2), CCND2(1), CDK4(6), CDKN1B(1), DAZL(3), EGR1(10), ESR2(4), FSHR(2), GJA4(1), MLH1(3), NCOR1(7), NR5A1(1), NRIP1(7), PGR(5), PRLR(3), PTGER2(1), SMPD1(6), VDR(2), ZP2(6)	34185059	91	78	79	17	10	11	10	29	30	1	0.0991	1.000	1.000
305	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(5), PLCE1(6), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAP2B(2)	14475925	31	31	31	9	4	3	3	13	8	0	0.693	1.000	1.000
306	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1)	24204700	67	62	62	15	9	18	5	23	12	0	0.125	1.000	1.000
307	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CFL1(1), CHN1(2), LIMK1(7), MAP3K1(8), MYL2(1), MYLK(4), NCF2(1), PAK1(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(9), VAV1(4), WASF1(1)	35067461	79	73	71	14	4	13	7	30	25	0	0.127	1.000	1.000
308	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), TNFAIP3(2), TRAF3(1), TRAF6(2)	18573647	33	31	30	7	2	8	0	9	13	1	0.499	1.000	1.000
309	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NEU1(1)	19751506	31	29	31	7	5	4	4	14	4	0	0.299	1.000	1.000
310	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(7), FYN(2), LRP8(4), RELN(7), VLDLR(4)	14040613	24	23	19	7	2	5	0	6	11	0	0.905	1.000	1.000
311	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(2), APC(9), AXIN1(5), BTRC(2), CTNNB1(2), DLL1(1), DVL1(1), FZD1(4), GSK3B(3), NOTCH1(12), WNT1(2)	20334446	43	41	40	10	6	6	3	17	10	1	0.364	1.000	1.000
312	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(3), CASP9(2), DAXX(6), FAS(2), FASLG(3), HSPB2(2), MAPKAPK2(1), TNF(1)	10996543	21	19	21	6	2	5	2	7	5	0	0.599	1.000	1.000
313	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(2), CREBBP(10), EP300(16), MAP3K7(3), MAPK3(3), SKIL(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2)	25692930	52	48	49	10	3	6	10	20	12	1	0.140	1.000	1.000
314	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(3), ABAT(1), ACY3(1), ADSL(3), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), ASRGL1(4), ASS1(3), CAD(13), CRAT(3), DARS(3), DARS2(1), DDO(1), DLAT(2), DLD(4), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1)	37685397	92	74	85	16	5	10	15	25	35	2	0.0798	1.000	1.000
315	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(9), AR(5), ASAH1(3), BRAF(4), CAMP(1), DAG1(3), EGFR(10), GNA11(1), GNA15(1), GNAI1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), MAPK10(2), MAPK14(1), PHKA2(5), PIK3CA(14), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(4), SRC(4)	53265732	114	94	106	18	10	25	19	40	19	1	0.00249	1.000	1.000
316	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IL15(1), IL16(5), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1)	9777111	16	16	16	6	0	7	2	6	1	0	0.619	1.000	1.000
317	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(8), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(4), SOS1(9)	15437433	54	49	47	13	3	14	5	22	10	0	0.312	1.000	1.000
318	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2)	30758903	57	52	50	10	3	7	11	17	19	0	0.170	1.000	1.000
319	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(20), ATR(12), BRCA1(9), BRCA2(14), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(1), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(3), RAD17(2), RAD50(4), RAD51(2), TP53(50), TREX1(3)	44391929	138	109	128	24	11	21	17	52	34	3	0.0159	1.000	1.000
320	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(3), GLI2(4), GLI3(7), GSK3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SHH(3), SMO(4), SUFU(3)	15784321	44	39	41	12	5	5	3	17	14	0	0.596	1.000	1.000
321	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), MAPK3(3), PIK3CA(14), PIK3R1(5), RAF1(4), SHC1(4), SOS1(9)	18497862	54	49	49	13	7	13	6	20	8	0	0.182	1.000	1.000
322	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(3), MYL2(1), MYLK(4), PLCB1(4), PPP1R12B(2), PRKCA(2), ROCK1(5)	20532945	34	34	34	8	3	2	2	19	8	0	0.513	1.000	1.000
323	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), GTF2I(4), GTF2IRD1(2), STON1(3), TAF1(8), TAF10(1), TAF13(1), TAF1L(10), TAF2(6), TAF4(7), TAF4B(8), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(7), TAF9B(2), TBPL2(1)	36296949	84	75	80	16	5	13	13	33	20	0	0.0493	1.000	1.000
324	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), XYLB(2)	27074632	63	57	61	14	5	7	15	19	17	0	0.264	1.000	1.000
325	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6)	18274417	50	45	47	12	4	6	11	19	10	0	0.376	1.000	1.000
326	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TAT(2), TPO(4)	21679052	58	51	55	14	8	6	14	16	14	0	0.295	1.000	1.000
327	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	36204338	78	75	74	16	5	12	16	29	15	1	0.117	1.000	1.000
328	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(4), FH(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PDK1(1), PDK2(3), PDK3(2), PDK4(1), PDP2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2)	28412255	77	65	74	18	3	15	9	26	23	1	0.242	1.000	1.000
329	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(5), IMPA1(1), PGM1(1)	10177273	9	8	9	7	3	0	0	4	2	0	0.963	1.000	1.000
330	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(2), AKT1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(3), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAC1(1), RPS6KA1(8), RPS6KA5(2), SOS1(9)	28942909	78	74	68	17	7	15	6	34	15	1	0.230	1.000	1.000
331	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CPT1A(2), CPT1C(4), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(6), GCDH(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), PECI(1)	49080635	110	95	91	22	7	14	18	47	23	1	0.0747	1.000	1.000
332	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2)	9864830	16	16	16	7	3	2	1	8	2	0	0.735	1.000	1.000
333	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), AXIN1(5), BTRC(2), CREBBP(10), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(2), DVL1(1), FZD1(4), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2)	29096292	66	57	60	14	7	6	7	23	22	1	0.231	1.000	1.000
334	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GLS(7), GLS2(4), GLUL(2), GMPS(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(1)	33229940	69	60	65	13	5	9	12	25	17	1	0.162	1.000	1.000
335	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(3), CALCRL(2), CD97(6), CRHR1(2), CRHR2(3), ELTD1(4), EMR1(2), EMR2(4), GIPR(2), GLP1R(3), GLP2R(3), GPR64(3), LPHN1(5), LPHN2(4), LPHN3(10), SCTR(1), VIPR1(1), VIPR2(2)	27394928	62	54	61	14	11	7	10	24	10	0	0.156	1.000	1.000
336	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(1), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(4), HK1(5), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), NPL(6), PHPT1(1), RENBP(4)	28703491	58	56	55	11	8	6	8	20	15	1	0.0795	1.000	1.000
337	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(5), AKT3(3), CISH(2), GRB2(2), IARS(4), IL13RA1(2), IL4(1), IL4R(4), INPP5D(2), JAK1(7), JAK2(7), JAK3(4), PI3(1), PIK3CA(14), PPP1R13B(4), RPS6KB1(2), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT6(5), TYK2(7)	36548116	103	85	97	21	7	20	18	37	21	0	0.0512	1.000	1.000
338	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(7), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(2), RAF1(4), SHC1(4), SOS1(9), SRF(1), STAT3(3)	23498579	62	58	62	15	5	7	10	26	14	0	0.395	1.000	1.000
339	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), AXIN1(5), CREBBP(10), CTNNB1(2), DVL1(1), EP300(16), FZD1(4), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(12), WNT1(2)	32696619	73	64	64	15	6	5	10	29	23	0	0.256	1.000	1.000
340	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5)	10376815	19	19	18	8	3	4	2	8	2	0	0.677	1.000	1.000
341	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(10), ABCC2(4), ABCG2(2), BCHE(3), CES1(8), CES2(2), CYP3A5(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5)	22967930	51	43	46	13	3	5	10	15	18	0	0.593	1.000	1.000
342	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(5), IMPA1(1), IMPA2(3), PGM1(1)	11508127	12	11	12	8	4	0	0	5	3	0	0.962	1.000	1.000
343	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(2), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLG(6), POLG2(5), POLH(5), POLI(3), POLK(5), POLL(2), POLM(4), POLQ(13), PRIM1(3), PRIM2(7), REV1(5), REV3L(17), RFC5(3)	41235141	98	83	92	18	5	8	7	46	32	0	0.294	1.000	1.000
344	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(7), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3), SYK(2)	23192421	54	52	53	13	7	7	9	18	13	0	0.323	1.000	1.000
345	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(4), ALDH18A1(1), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), GATM(2), NAGS(1), OAT(2), ODC1(2), OTC(1), PYCR1(1), SMS(2)	17506301	30	29	30	9	1	2	5	14	8	0	0.815	1.000	1.000
346	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BAX(1), BID(2), BIK(1), BIRC2(3), BIRC3(5), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), DIABLO(1)	13557694	23	23	23	8	1	4	5	8	5	0	0.707	1.000	1.000
347	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(5), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), MLYCD(3), SMS(2), UPB1(2)	28727325	73	67	70	19	4	11	17	23	16	2	0.286	1.000	1.000
348	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(4), GNAI1(2), GNB1(3), MAP3K7(3), PIK3CA(14), PIK3R1(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2B(3), ROCK1(5)	25627043	59	56	54	13	8	12	5	22	11	1	0.156	1.000	1.000
349	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), LTA(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1), TRAF3(1)	22639343	36	33	33	9	3	8	0	11	13	1	0.589	1.000	1.000
350	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(2), CAP1(3), CCNB1(1), CDC25C(3), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), MAPK3(3), MYT1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RPS6KA1(8), SRC(4)	20081799	55	51	50	14	7	8	4	24	11	1	0.448	1.000	1.000
351	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IKBKB(3), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TNFRSF9(1), TNFSF9(1), TRAF2(1)	19715506	41	37	38	10	2	5	1	18	14	1	0.757	1.000	1.000
352	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), GNMT(2), MAOA(2), MAOB(2), PHGDH(3), PIPOX(3), PISD(2), PSAT1(2), RDH11(4), RDH13(1), SARDH(5), SARS(3), SARS2(1), SHMT1(2), SHMT2(5), TARS(6), TARS2(7)	42587499	110	98	106	24	13	18	18	37	23	1	0.0623	1.000	1.000
353	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(3), ACADM(1), ACADS(3), ACAT1(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(2), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	43391069	87	83	83	17	6	11	22	31	16	1	0.0584	1.000	1.000
354	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(7), FYN(2), GSN(5), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PIK3CA(14), PIK3R1(5), PTK2(3), PXN(3), RAF1(4), ROCK1(5), SHC1(4), SRC(4), TLN1(14)	37368121	100	89	94	21	7	18	11	36	28	0	0.178	1.000	1.000
355	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(7), JAK2(7), JAK3(4), PIAS3(3), PTPRU(5), SRC(4), STAT3(3)	15110643	37	33	37	10	2	5	5	15	10	0	0.628	1.000	1.000
356	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(5), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), MYST3(4), MYST4(3), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(2), TPO(4)	33768970	70	61	67	15	9	8	14	22	17	0	0.176	1.000	1.000
357	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), ATP7A(5), ATP7B(8), COX10(5), COX5A(1), COX6A2(1), COX7A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(2)	38390393	104	94	102	24	7	17	19	41	19	1	0.150	1.000	1.000
358	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(3), HDAC5(3), IGF1R(3), INS(1), INSR(6), MAP2K6(1), MAPK14(1), MAPK7(4), MEF2A(3), MEF2D(1), NFATC1(4), NFATC2(8), PIK3CA(14), PIK3R1(5), PPP3CA(3), PPP3CC(3), SYT1(1)	34121501	82	75	71	19	11	14	7	28	22	0	0.203	1.000	1.000
359	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(2), GFPT1(3), GNE(1), GNPDA1(1), HEXA(4), HK1(5), RENBP(4)	16947245	23	22	23	7	4	0	2	12	5	0	0.732	1.000	1.000
360	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JAK2(7), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(3), RAF1(4), RPS6KA1(8), SHC1(4), SLC2A4(3), SOS1(9), SRF(1), STAT5A(3), STAT5B(3)	32700934	89	78	75	20	7	15	15	29	22	1	0.246	1.000	1.000
361	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), NT5M(2), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(2)	57025029	118	96	109	21	9	15	17	34	41	2	0.0522	1.000	1.000
362	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(5), DBH(2), DDC(3), GAD1(2), GAD2(2), HDC(1), MAOA(2), PAH(6), SLC18A3(2), TH(4), TPH1(2)	13885177	32	31	30	10	3	5	8	8	8	0	0.632	1.000	1.000
363	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA1(2), FUCA2(1), GALNS(6), GBA(3), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NAGLU(2), NEU1(1), SPAM1(8)	33873228	83	69	78	19	13	10	11	37	12	0	0.113	1.000	1.000
364	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(4), AKT1(3), CALM2(1), CALR(2), CAMK1(3), CAMK1G(3), CAMK4(3), CREBBP(10), CSNK1A1(2), ELSPBP1(2), F2(4), FGF2(1), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), MAPK14(1), MAPK3(3), MYH2(9), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKX2-5(3), NPPA(1), PIK3CA(14), PIK3R1(5), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAF1(4), RPS6KB1(2), SYT1(1)	49735722	131	112	121	28	14	20	11	45	41	0	0.117	1.000	1.000
365	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), DAG1(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFAT5(10), PDE6A(1), PDE6B(6), PDE6C(3), SLC6A13(7)	35983094	65	59	64	13	6	7	14	27	11	0	0.0993	1.000	1.000
366	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(9), ATF2(2), AXIN1(5), BMP10(1), BMP2(2), BMP4(1), BMP5(1), BMP7(5), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(2), DVL1(1), FZD1(4), GATA4(2), GSK3B(3), MAP3K7(3), MYL2(1), NKX2-5(3), NOG(2), NPPA(1), NPPB(1), RFC1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), WNT1(2)	35696562	79	67	77	17	12	7	5	33	21	1	0.180	1.000	1.000
367	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(4), DAG1(3), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), LYN(1), MAP2K2(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4)	51640144	115	98	109	21	12	21	18	43	21	0	0.0101	1.000	1.000
368	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX5(4), CBR1(4), CYP4F2(4), CYP4F3(2), EPX(3), GGT1(4), LPO(1), LTA4H(4), MPO(6), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4)	27591028	66	61	63	16	8	6	19	19	13	1	0.276	1.000	1.000
369	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(4)	24467737	55	51	55	14	4	7	15	15	14	0	0.332	1.000	1.000
370	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(2), GHR(1), HRAS(1), IGF1R(3), PIK3CA(14), PIK3R1(5), SHC1(4)	13024190	33	31	28	10	3	9	3	13	5	0	0.560	1.000	1.000
371	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(2), EPHB2(2), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(4), MAPK7(4), MYEF2(1), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RAF1(4), RASAL1(8), SRC(4), TEC(6), VAV1(4)	27320060	66	61	59	16	9	7	8	26	16	0	0.386	1.000	1.000
372	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K14(2), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(6), TGFBR1(1), TGFBR2(2), TLR2(2), TNF(1)	29534966	64	54	58	14	5	9	7	20	21	2	0.345	1.000	1.000
373	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(10), CMA1(1), CTSA(1), ENPEP(7), LNPEP(4), MAS1(1), MME(6), REN(1), THOP1(1)	21043556	49	43	44	14	2	6	13	18	10	0	0.672	1.000	1.000
374	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(6), AKT1(3), AKT2(5), AKT3(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CAPN1(3), CAPN2(4), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CSF2RB(5), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), MAP3K14(2), NFKB1(2), NFKB2(3), NFKBIA(2), NTRK1(8), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF1A(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1)	83805472	255	195	231	42	25	36	32	95	63	4	0.000215	1.000	1.000
375	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22(1), IL22RA1(3), IL22RA2(1), JAK1(7), JAK2(7), JAK3(4), SOCS3(1), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), TYK2(7)	18363912	50	48	48	14	4	0	10	22	14	0	0.808	1.000	1.000
376	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), MAOA(2), MAOB(2), TAT(2), TH(4), TPO(4), TYR(5)	31347067	80	71	76	22	11	7	9	32	21	0	0.579	1.000	1.000
377	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	GORASP1(1), IKBKG(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK5(1), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PIK3CA(14), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	33129081	64	59	59	14	10	13	6	25	10	0	0.106	1.000	1.000
378	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(2), CD3G(2), ETV5(3), IL12RB1(4), IL12RB2(2), IL18R1(1), JAK2(7), JUN(2), MAP2K6(1), MAPK14(1), STAT4(2), TYK2(7)	18708322	35	34	34	10	3	2	6	16	8	0	0.714	1.000	1.000
379	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(2), NFATC1(4), NFATC2(8), NFKB1(2), NFKBIA(2), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), SYT1(1), VIPR2(2)	27229521	65	60	59	17	8	6	1	23	26	1	0.694	1.000	1.000
380	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IKBKG(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	22330282	50	45	44	13	3	8	7	12	19	1	0.574	1.000	1.000
381	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1B10(3), AKR1C4(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), LIPA(1), RDH11(4), RDH13(1), SLC27A5(3), SOAT1(4), SOAT2(4), SRD5A1(1)	31685848	68	63	63	17	7	5	7	30	19	0	0.515	1.000	1.000
382	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP1(1), ARHGAP5(6), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(3), ARPC1B(2), ARPC2(9), BAIAP2(2), CFL1(1), DIAPH1(7), GSN(5), LIMK1(7), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PIP5K1B(1), PPP1R12B(2), ROCK1(5), SRC(4), TLN1(14), VCL(2)	45557010	91	79	81	17	4	10	9	30	38	0	0.196	1.000	1.000
383	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), GPI(3), H6PD(3), PFKL(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TALDO1(2), TKT(2), TKTL1(2), TKTL2(6)	23959576	50	49	48	14	6	8	6	16	14	0	0.536	1.000	1.000
384	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(10), EP300(16), FYN(2), IL7R(1), JAK1(7), JAK3(4), LCK(1), PIK3CA(14), PIK3R1(5), PTK2B(3), STAT5A(3), STAT5B(3)	27958379	69	63	60	17	4	14	12	21	18	0	0.332	1.000	1.000
385	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2)	28654943	66	56	66	16	13	13	3	27	10	0	0.123	1.000	1.000
386	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(3), ALG5(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1B1(1), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), RPN1(3), RPN2(1), ST6GAL1(1)	19414258	37	35	37	10	2	9	1	13	12	0	0.446	1.000	1.000
387	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(1), CASP8(1), MAP3K1(8), MAPK3(3), NFKB1(2), NSMAF(7), RAF1(4), RELA(6), RIPK1(1), SMPD1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	20354567	44	40	40	12	4	7	6	13	13	1	0.522	1.000	1.000
388	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BAD(1), CBL(3), CFLAR(1), CRKL(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(5), JAK1(7), JAK3(4), MAPK3(3), MYC(2), PIK3CA(14), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(4), RPS6KB1(2), SHC1(4), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(3), SYK(2)	35397378	90	82	84	21	9	18	15	28	20	0	0.145	1.000	1.000
389	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(8), CLTA(1), CLTB(2), COPA(6), GBF1(13), GPLD1(2), KDELR2(2), KDELR3(6)	16342389	44	42	44	13	2	2	7	19	12	2	0.801	1.000	1.000
390	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(10), EP300(16), LPL(3), NCOA1(4), NCOA2(11), PPARG(2)	18385145	46	37	37	14	4	6	5	12	19	0	0.654	1.000	1.000
391	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3E(2), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), LAT(1), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3CA(14), PIK3R1(5), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PTPN7(1), RAC1(1), RAF1(4), RASA1(7), RELA(6), SHC1(4), SOS1(9), SYT1(1), VAV1(4), ZAP70(1)	47050549	122	106	111	27	12	26	10	38	35	1	0.196	1.000	1.000
392	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(3), AP2M1(1), BIN1(6), CALM2(1), DNM1(4), EPN1(1), EPS15(3), PICALM(3), PPP3CA(3), PPP3CC(3), SYNJ1(6), SYNJ2(6), SYT1(1)	22148223	45	44	43	13	2	6	8	20	9	0	0.570	1.000	1.000
393	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), ATF2(2), CALM2(1), EGFR(10), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK3(3), MEF2A(3), MEF2D(1), PAK1(3), PRKCA(2), PTK2(3), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1)	33840107	75	64	73	18	7	16	9	26	17	0	0.301	1.000	1.000
394	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(10), MAP3K1(8), MAPK14(1), NCOR2(7), RARA(4), THRA(2)	17113989	37	33	35	11	2	5	7	10	13	0	0.756	1.000	1.000
395	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(3), CAPN2(4), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(14)	32783740	81	72	78	20	9	7	7	36	22	0	0.485	1.000	1.000
396	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), BST1(2), CD38(1), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(2), QPRT(1)	21512856	42	40	41	12	3	3	4	24	8	0	0.657	1.000	1.000
397	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ACY3(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2)	39158508	86	74	83	20	8	15	14	30	19	0	0.156	1.000	1.000
398	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(6), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	24309100	48	44	44	14	4	9	6	18	10	1	0.588	1.000	1.000
399	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(9), AXIN1(5), CTNNB1(2), DVL1(1), FZD1(4), GNAI1(2), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(2), PIK3CA(14), PIK3R1(5), PPP2CA(1), RELA(6), TLR4(3), WNT1(2)	30077777	70	67	60	18	5	14	7	25	18	1	0.363	1.000	1.000
400	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), DAXX(6), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP2K6(1), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MYC(2), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(2), SHC1(4), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1)	36779176	78	68	76	18	8	6	5	38	20	1	0.446	1.000	1.000
401	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3)	24936921	39	35	34	10	2	4	4	18	11	0	0.702	1.000	1.000
402	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HMGCL(1), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1)	25781560	49	48	45	14	6	8	10	15	10	0	0.430	1.000	1.000
403	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(4), FLT1(10), FLT4(14), KDR(6), NOS3(4), PDE2A(3), PDE3A(4), PDE3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKG1(4), PRKG2(3), RYR2(17), SLC7A1(3), SYT1(1), TNNI1(1)	41123979	99	90	99	24	17	15	9	42	16	0	0.140	1.000	1.000
404	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD28(1), CSK(4), CTLA4(3), DAG1(3), DTYMK(1), EPHB2(2), FBXW7(6), GRAP2(1), GRB2(2), ITK(2), ITPKA(2), ITPKB(2), LAT(1), LCK(1), LCP2(3), NCK1(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLCG1(4), PTPRC(8), RAF1(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(9), SOS2(7), VAV1(4), ZAP70(1)	55484143	127	103	124	25	13	18	21	43	32	0	0.0515	1.000	1.000
405	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), GPI(3), H6PD(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TAL1(3), TALDO1(2), TKT(2)	19900363	42	40	40	13	5	5	6	13	13	0	0.726	1.000	1.000
406	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	20011083	43	38	40	13	5	5	3	10	19	1	0.831	1.000	1.000
407	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(3), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NCF1(1), NCF2(1), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3C2G(5), PLCB1(4), PPP3CA(3), PPP3CC(3), RAC1(1), RAF1(4), RELA(6), SYT1(1)	38247438	91	78	85	22	12	10	6	32	30	1	0.500	1.000	1.000
408	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(2), GNB1(3), GRB2(2), HRAS(1), JAK2(7), MAP2K2(1), MAPK14(1), MAPK3(3), MAPT(4), MYLK(4), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), SYT1(1)	41878239	86	76	84	19	6	11	11	36	22	0	0.312	1.000	1.000
409	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(8), ACADL(3), ACADM(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2)	33253878	70	66	66	18	4	9	17	23	15	2	0.326	1.000	1.000
410	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(4), ADC(2), AGMAT(3), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CPS1(6), GATM(2), MAOA(2), MAOB(2), NAGS(1), ODC1(2), OTC(1), SAT1(1), SAT2(2), SMS(2)	29254429	70	64	68	19	4	8	13	27	18	0	0.542	1.000	1.000
411	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(2), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GFPT2(1), GLS(7), GLS2(4), GLUD2(7), GLUL(2), GMPS(1), GNPNAT1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(1)	39509883	84	70	78	20	7	9	17	30	20	1	0.349	1.000	1.000
412	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(5), CLYBL(3), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), OGDHL(2), PC(8), PCK1(5), PCK2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2)	29805307	84	71	81	24	5	15	8	33	22	1	0.562	1.000	1.000
413	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT1(3), AKT2(5), AKT3(3), DAG1(3), IKBKG(1), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(5), PITX2(2), PLD1(3), PLD2(7), PLD3(3)	44709441	83	69	81	18	11	12	14	31	15	0	0.0695	1.000	1.000
414	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(2), ARRB2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA4(2), CNGA3(5), CNGA4(4), CNGB1(6), GUCA1B(2), PDC(1), PDE1C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKG1(4), PRKG2(3), PRKX(2)	30876627	60	57	57	16	8	7	5	28	12	0	0.511	1.000	1.000
415	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(3), AKT2(5), AKT3(3), BRD4(5), CAP1(3), CBL(3), CDC42(1), CDKN2A(5), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), LNPEP(4), MAPK3(3), PARD3(6), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PTEN(34), PTPN1(2), RAF1(4), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(3), SOS1(9), SOS2(7), YWHAE(1)	57220489	167	138	153	31	13	24	27	48	51	4	0.0269	1.000	1.000
416	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(10), APOA1(1), CETP(1), DGAT1(2), LCAT(5), LDLR(3), LIPC(1), LPL(3), LRP1(15), SCARB1(4), SOAT1(4)	26955573	49	45	47	13	4	10	5	19	11	0	0.355	1.000	1.000
417	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), SOAT2(4), SRD5A1(1)	23224668	47	44	44	15	4	3	6	22	12	0	0.855	1.000	1.000
418	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), REN(1)	25559695	43	40	43	14	4	12	5	16	6	0	0.433	1.000	1.000
419	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(6), BIRC2(3), BIRC3(5), BRAF(4), CAPN2(4), CAV2(2), CAV3(1), CCND2(1), CDC42(1), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), CRKL(1), CTNNB1(2), DIAPH1(7), DOCK1(3), EGF(5), EGFR(10), ELK1(1), ERBB2(8), FARP2(3), FIGF(2), FLNA(6), FLNB(7), FLNC(10), FLT1(10), FN1(8), FYN(2), GRB2(2), GRLF1(6), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(3), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), JUN(2), KDR(6), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), MAPK10(2), MAPK3(3), MAPK9(2), MET(22), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PGF(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PRKCA(2), PRKCG(6), PTEN(34), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF1(6), RELN(7), ROCK1(5), ROCK2(4), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SPP1(3), SRC(4), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TLN1(14), TLN2(12), TNC(13), TNN(3), TNR(9), TNXB(11), VAV1(4), VAV2(4), VAV3(1), VCL(2), VEGFC(2), VTN(1), VWF(15), ZYX(1)	367880941	862	433	831	232	86	117	119	312	220	8	0.139	1.000	1.000
420	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(4), ACVR1C(3), AKT1(3), AKT2(5), AKT3(3), ARRB1(3), ARRB2(1), ATF2(2), ATF4(2), BDNF(2), BRAF(4), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D4(5), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(2), CACNG3(2), CACNG4(1), CACNG5(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), CRKL(1), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(2), DUSP6(2), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(1), ELK4(3), FAS(2), FASLG(3), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FLNA(6), FLNB(7), FLNC(10), FOS(1), GADD45B(1), GNA12(1), GNG12(2), GRB2(2), HRAS(1), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1R2(8), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAPT(4), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(2), NF1(11), NFATC2(8), NFATC4(3), NFKB1(2), NFKB2(3), NLK(1), NR4A1(1), NRAS(2), NTRK1(8), NTRK2(2), PAK1(3), PAK2(4), PDGFRA(8), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(3), PPM1B(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PPP5C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(5), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF2(8), RASA1(7), RASA2(2), RASGRF1(8), RASGRF2(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KA6(1), RRAS2(8), SOS1(9), SOS2(7), SRF(1), STK3(1), TAOK2(4), TAOK3(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF1A(1), TP53(50), TRAF2(1), TRAF6(2), ZAK(4)	287633554	690	386	653	179	85	86	89	251	172	7	0.0699	1.000	1.000
421	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY7(1), ADCY8(13), ADCY9(7), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(8), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(4), CD38(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(8), ERBB4(11), F2R(2), GNA11(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(8), GRIN2D(2), GRM1(5), GRM5(9), GRPR(2), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), LTB4R2(1), MYLK(4), MYLK2(1), NOS1(10), NOS3(4), NTSR1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), PDE1A(1), PDE1B(5), PDE1C(2), PDGFRA(8), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTAFR(2), PTGER3(5), PTGFR(5), PTK2B(3), RYR1(23), RYR2(17), RYR3(17), SLC25A4(2), SLC25A5(4), SLC25A6(2), SLC8A1(3), SLC8A2(3), SLC8A3(5), SPHK1(2), SPHK2(1), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(3), VDAC2(1), VDAC3(2)	270534741	599	371	578	177	106	79	64	226	124	0	0.224	1.000	1.000
422	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), APC(9), APC2(5), ARAF(1), ARHGEF1(2), ARHGEF12(5), ARHGEF4(2), ARHGEF6(4), ARHGEF7(5), ARPC1B(2), ARPC2(9), ARPC5L(1), BAIAP2(2), BCAR1(6), BDKRB1(1), BDKRB2(1), BRAF(4), C3orf10(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CRKL(1), CSK(4), CYFIP1(7), CYFIP2(7), DIAPH1(7), DIAPH2(2), DIAPH3(7), DOCK1(3), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(3), FGD3(1), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FN1(8), GIT1(4), GNA12(1), GNA13(4), GNG12(2), GRLF1(6), GSN(5), HRAS(1), INS(1), IQGAP1(7), IQGAP2(7), IQGAP3(7), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(7), LIMK2(4), MAP2K2(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(3), MYH14(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), NCKAP1(3), NCKAP1L(5), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDGFRA(8), PDGFRB(3), PFN2(1), PFN3(1), PFN4(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R12B(2), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RDX(2), ROCK1(5), ROCK2(4), RRAS2(8), SCIN(4), SLC9A1(3), SOS1(9), SOS2(7), SSH1(2), SSH2(12), SSH3(2), TIAM1(9), TIAM2(1), VAV1(4), VAV2(4), VAV3(1), VCL(2), WAS(1), WASF1(1), WASF2(2), WASL(7)	278077848	640	368	599	155	63	85	86	240	162	4	0.0388	1.000	1.000
423	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(7), ACTG1(3), CHAD(3), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DES(1), DSC2(5), DSC3(3), DSG1(4), DSG2(3), DSG3(3), DSG4(5), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(2), GJA9(1), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GJC1(3), GJC2(1), GJD2(1), IBSP(1), ITGA6(6), ITGB4(6), KRT1(3), KRT10(2), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(3), KRT18(1), KRT19(2), KRT2(6), KRT20(1), KRT23(3), KRT24(1), KRT25(1), KRT27(4), KRT28(2), KRT3(2), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(2), KRT5(3), KRT6A(3), KRT6B(3), KRT6C(1), KRT7(1), KRT71(3), KRT72(2), KRT73(2), KRT74(2), KRT75(4), KRT76(4), KRT77(4), KRT78(3), KRT79(4), KRT81(1), KRT82(2), KRT83(2), KRT84(4), KRT85(6), KRT86(2), KRT9(2), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), LMNB1(3), LMNB2(1), NES(8), PRPH(3), RELN(7), SPP1(3), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15)	243650837	554	332	540	191	64	75	65	202	146	2	0.940	1.000	1.000
424	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(3), CALCR(3), CALCRL(2), CCKAR(4), CCKBR(4), CGA(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(3), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(5), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(3), GABRB2(3), GABRB3(2), GABRD(2), GABRE(5), GABRG1(3), GABRG2(6), GABRG3(3), GABRQ(8), GABRR1(2), GABRR2(1), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(3), GLRA1(3), GLRA2(2), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(8), GRIA2(4), GRIA3(2), GRIA4(4), GRID1(4), GRID2(9), GRIK1(4), GRIK2(5), GRIK3(6), GRIK5(5), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRIN3A(2), GRIN3B(5), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM6(2), GRM7(5), GRM8(4), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), LEP(1), LEPR(5), LTB4R2(1), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPBWR1(2), NPBWR2(1), NPFFR2(3), NPY1R(2), NPY2R(2), NR3C1(4), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(6), PRLR(3), PRSS1(6), PRSS3(12), PTAFR(2), PTGDR(2), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(5), PTGIR(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TAAR2(2), TAAR9(2), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(1), TSHR(2), TSPO(1), UTS2R(2), VIPR1(1), VIPR2(2)	215683005	495	311	479	160	79	69	70	184	93	0	0.451	1.000	1.000
425	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(10), CD36(1), CD44(3), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DAG1(3), FN1(8), FNDC1(3), FNDC3A(4), FNDC5(1), GP6(1), GP9(1), HMMR(1), HSPG2(14), IBSP(1), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), RELN(7), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SPP1(3), SV2A(1), SV2B(3), SV2C(3), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15)	220714199	475	309	462	144	50	62	61	168	131	3	0.636	1.000	1.000
426	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), AMOTL1(4), ASH1L(8), CASK(2), CDC42(1), CDK4(6), CGN(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CSDA(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(7), EXOC4(3), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), HCLS1(1), HRAS(1), IGSF5(5), INADL(10), JAM3(1), KRAS(3), LLGL1(5), LLGL2(3), MAGI1(5), MAGI2(6), MAGI3(4), MLLT4(11), MPDZ(4), MPP5(1), MRAS(1), MYH1(5), MYH10(3), MYH11(10), MYH13(7), MYH14(8), MYH15(5), MYH2(9), MYH3(7), MYH4(15), MYH6(7), MYH7(13), MYH7B(7), MYH8(6), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLPF(3), NRAS(2), OCLN(3), PARD3(6), PARD6B(8), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PTEN(34), RAB13(1), RAB3B(1), RRAS2(8), SPTAN1(12), SRC(4), SYMPK(1), TJAP1(4), TJP1(6), TJP2(4), TJP3(1), YES1(2), ZAK(4)	193783294	461	290	435	132	44	54	58	144	156	5	0.724	1.000	1.000
427	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADRA1A(4), ADRB2(2), ANXA6(3), ARRB1(3), ARRB2(1), ATP1A4(4), ATP1B1(5), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GNA11(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), ITPR1(7), ITPR2(13), ITPR3(5), KCNB1(2), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PKIB(1), PLCB3(3), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SLC8A3(5), USP5(4)	189765843	419	284	408	128	75	53	42	150	99	0	0.392	1.000	1.000
428	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(1), ACVR1B(4), ACVR2A(4), ACVR2B(1), AMHR2(9), BMP2(2), BMP7(5), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL2(1), CCL27(2), CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CD27(3), CD40(1), CLCF1(1), CNTF(1), CSF1R(8), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(2), CX3CR1(1), CXCL1(1), CXCL11(1), CXCL13(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(2), EDA2R(1), EGF(5), EGFR(10), EPOR(3), FAS(2), FASLG(3), FLT1(10), FLT3(6), FLT4(14), GDF5(5), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL17RA(1), IL17RB(4), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(8), IL1RAP(4), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), INHBA(2), INHBB(2), INHBC(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEP(1), LEPR(5), LIFR(5), LTA(1), LTB(1), LTBR(2), MET(22), NGFR(1), OSM(2), OSMR(1), PDGFC(1), PDGFRA(8), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(9), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFC(2), XCL1(3), XCR1(1)	175827295	400	284	382	76	37	56	52	167	88	0	0.000418	1.000	1.000
429	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(9), ABLIM1(5), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(4), EFNA1(2), EFNA3(1), EFNB1(1), EFNB2(1), EFNB3(12), EPHA1(4), EPHA2(1), EPHA3(5), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(2), EPHA8(7), EPHB1(4), EPHB2(2), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(2), GNAI2(2), GNAI3(2), GSK3B(3), HRAS(1), ITGB1(7), KRAS(3), L1CAM(5), LIMK1(7), LIMK2(4), LRRC4C(2), MAPK3(3), MET(22), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NGEF(1), NRAS(2), NRP1(2), NTN4(2), NTNG1(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLXNA1(4), PLXNA2(10), PLXNA3(5), PLXNB1(10), PLXNB2(6), PLXNB3(4), PLXNC1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTK2(3), RAC1(1), RAC2(1), RAC3(1), RASA1(7), RGS3(8), RND1(3), ROBO1(5), ROBO2(9), ROBO3(4), ROCK1(5), ROCK2(4), SEMA3A(4), SEMA3B(1), SEMA3C(2), SEMA3D(4), SEMA3E(3), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(7), SEMA4G(4), SEMA5A(6), SEMA5B(2), SEMA6A(3), SEMA6B(2), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(9), SLIT3(8), SRGAP1(10), SRGAP2(3), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(3), UNC5D(2)	193437899	445	279	406	119	47	55	52	163	126	2	0.420	1.000	1.000
430	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(9), APC2(5), AXIN1(5), AXIN2(1), BTRC(2), CACYBP(4), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(6), CREBBP(10), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(3), CTNNB1(2), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(1), DKK2(1), DVL1(1), DVL2(1), EP300(16), FBXW11(2), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(8), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKD1(4), NKD2(4), NLK(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRICKLE1(4), PRICKLE2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAC1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(5), ROCK2(4), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(2), SMAD2(2), SMAD3(2), SMAD4(3), TBL1X(3), TBL1XR1(5), TCF7L1(2), TCF7L2(1), TP53(50), VANGL1(5), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	158087262	392	271	370	88	40	41	53	138	116	4	0.0187	1.000	1.000
431	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(8), ACACB(5), AKT1(3), AKT2(5), AKT3(3), ARAF(1), BAD(1), BRAF(4), CALM2(1), CBL(3), CBLB(4), CBLC(2), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(6), FASN(9), FBP1(1), FLOT1(1), FLOT2(1), FOXO1(5), G6PC(3), GCK(2), GRB2(2), GSK3B(3), GYS1(3), GYS2(3), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(6), IRS1(5), IRS4(1), KRAS(3), LIPE(6), MAP2K2(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(1), NRAS(2), PCK1(5), PCK2(2), PDE3A(4), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PKLR(1), PKM2(1), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACA(2), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCI(5), PRKCZ(2), PRKX(2), PTPN1(2), PTPRF(8), PYGB(3), PYGL(2), PYGM(4), RAF1(4), RAPGEF1(6), RHEB(5), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SLC2A4(3), SOCS3(1), SOCS4(1), SORBS1(3), SOS1(9), SOS2(7), SREBF1(4), TRIP10(2), TSC1(6), TSC2(13)	157816448	369	266	349	77	35	60	52	143	76	3	0.00136	1.000	1.000
432	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ARRB1(3), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CREB3(2), CRHR1(2), DGKZ(5), ETS2(1), FOS(1), GABPA(2), GABPB2(1), GBA2(5), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(2), IGFBP6(3), IL1B(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), MIB1(1), MYL2(1), MYLK2(1), NFKB1(2), NOS1(10), NOS3(4), OXTR(1), PDE4B(2), PDE4D(2), PKIA(1), PKIB(1), PLCB3(3), PLCD1(3), PLCG1(4), PLCG2(4), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RLN1(1), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SP1(2), TNXB(11), USP5(4)	172236472	363	261	356	99	56	52	38	132	85	0	0.240	1.000	1.000
433	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(4), CADM1(3), CADM3(3), CD2(2), CD22(4), CD276(2), CD28(1), CD34(2), CD4(10), CD40(1), CD58(1), CD6(3), CD80(1), CD86(3), CD8A(1), CD99(2), CDH1(2), CDH15(1), CDH2(7), CDH3(3), CDH4(6), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CNTN1(7), CNTN2(3), CNTNAP1(9), CNTNAP2(5), CTLA4(3), ESAM(3), F11R(1), GLG1(5), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(6), ITGA8(3), ITGA9(3), ITGAL(7), ITGAM(9), ITGAV(1), ITGB1(7), ITGB2(2), ITGB7(4), ITGB8(1), JAM3(1), L1CAM(5), MADCAM1(3), MAG(1), MPZL1(2), NCAM1(3), NCAM2(6), NEGR1(2), NEO1(5), NFASC(8), NRCAM(5), NRXN1(10), NRXN2(6), NRXN3(5), OCLN(3), PDCD1(1), PTPRC(8), PTPRF(8), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SELE(6), SELL(2), SELP(2), SELPLG(3), SIGLEC1(5), SPN(1), VCAM1(6), VCAN(16)	143992420	378	258	366	131	36	47	55	156	83	1	0.935	1.000	1.000
434	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(8), ASH2L(3), CTCFL(5), DOT1L(9), EED(1), EHMT1(4), EHMT2(9), EZH1(3), EZH2(4), FBXO11(6), HCFC1(8), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(11), MEN1(1), MLL(6), MLL2(26), MLL3(38), MLL4(8), MLL5(9), NSD1(13), OGT(5), PAXIP1(4), PPP1CA(1), PPP1CC(2), PRDM2(4), PRDM6(1), PRDM7(5), PRDM9(8), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), RBBP5(5), SATB1(4), SETD1A(8), SETD1B(2), SETD2(72), SETD7(1), SETDB1(8), SETMAR(2), SMYD3(2), SUV39H2(5), SUV420H1(3), SUZ12(6), WHSC1(6), WHSC1L1(6)	121267645	351	253	346	70	27	40	42	112	125	5	0.0114	1.000	1.000
435	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(5), AKT3(3), CBL(3), CBLB(4), CBLC(2), CCND2(1), CISH(2), CLCF1(1), CNTF(1), CREBBP(10), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(16), EPOR(3), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), IRF9(2), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIFR(5), MYC(2), OSM(2), OSMR(1), PIAS1(5), PIAS2(3), PIAS3(3), PIAS4(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRLR(3), PTPN11(2), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(9), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(1), SPRY2(3), SPRY4(10), STAM(6), STAT1(6), STAT2(6), STAT3(3), STAT4(2), STAT5A(3), STAT5B(3), STAT6(5), TPO(4), TYK2(7)	144480171	350	240	329	79	27	53	58	130	82	0	0.0349	1.000	1.000
436	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADK(1), ADSL(3), ADSSL1(2), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), ENTPD5(3), ENTPD6(2), GART(4), GDA(3), GMPR(2), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NME7(2), NPR1(4), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(7), PDE1A(1), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PDE9A(10), PFAS(3), PKLR(1), PKM2(1), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PPAT(3), PRIM1(3), PRIM2(7), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(3), RRM1(3), RRM2(1), XDH(7)	163976468	330	231	315	76	32	46	37	128	87	0	0.0957	1.000	1.000
437	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(9), ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), ATM(20), ATR(12), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDC14A(5), CDC14B(1), CDC16(4), CDC20(3), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(3), CDC27(14), CDC6(2), CDC7(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(10), CUL1(5), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(13), FZR1(4), GADD45B(1), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), ORC1L(1), ORC2L(1), PCNA(4), PKMYT1(1), PLK1(1), PRKDC(13), PTTG2(1), RB1(4), RBL2(5), RBX1(1), SFN(1), SKP2(1), SMAD2(2), SMAD3(2), SMAD4(3), SMC1A(4), SMC1B(4), TGFB2(3), TGFB3(1), TP53(50), WEE1(2), YWHAE(1)	136939438	345	229	321	75	33	43	49	111	102	7	0.00827	1.000	1.000
438	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(3), BCAR1(6), CAPN1(3), CAPN10(2), CAPN11(5), CAPN2(4), CAPN3(8), CAPN5(3), CAPN6(2), CAPN7(4), CAPN9(3), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(3), FYN(2), GIT2(4), GRB2(2), ILK(4), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(1), MAPK7(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PIK3R2(3), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(5), ROCK2(4), SDCCAG8(1), SEPP1(4), SHC1(4), SHC3(2), SORBS1(3), SOS1(9), SRC(4), TLN1(14), TNS1(9), VAV2(4), VAV3(1), VCL(2), ZYX(1)	134851201	310	228	299	93	26	49	43	122	68	2	0.583	1.000	1.000
439	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), DRD1(1), DRD2(1), EGF(5), EGFR(10), GJD2(1), GNA11(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAS(5), GRB2(2), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAP2K5(4), MAP3K2(2), MAPK3(3), MAPK7(4), NPR1(4), NPR2(5), NRAS(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(9), SOS2(7), SRC(4), TJP1(6), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4)	131344298	295	213	288	92	36	46	30	120	63	0	0.695	1.000	1.000
440	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ACVR1B(4), ACVR1C(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(10), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(3), INSR(6), IQGAP1(7), LEF1(3), LMO7(12), MAP3K7(3), MAPK3(3), MET(22), MLLT4(11), NLK(1), PARD3(6), PTPN1(2), PTPN6(3), PTPRB(5), PTPRF(8), PTPRJ(12), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), RAC1(1), RAC2(1), RAC3(1), SMAD2(2), SMAD3(2), SMAD4(3), SNAI1(1), SNAI2(3), SORBS1(3), SRC(4), SSX2IP(5), TCF7L1(2), TCF7L2(1), TGFBR1(1), TGFBR2(2), TJP1(6), VCL(2), WAS(1), WASF1(1), WASF2(2), WASF3(3), WASL(7), YES1(2)	119883384	301	212	280	78	32	37	49	108	73	2	0.231	1.000	1.000
441	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BID(2), BRAF(4), CD48(1), FAS(2), FASLG(3), FCER1G(1), FCGR3B(2), FYN(2), GRB2(2), HCST(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), ITGAL(7), ITGB2(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(5), KLRC3(1), KRAS(3), LAT(1), LCK(1), LCP2(3), MAP2K2(1), MAPK3(3), MICA(1), MICB(4), NCR1(1), NCR2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NRAS(2), PAK1(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRF1(1), PRKCA(2), PRKCG(6), PTK2B(3), PTPN11(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D1B(1), SH3BP2(6), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFSF10(9), ULBP1(2), ULBP2(1), ULBP3(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	111508936	300	212	285	73	24	49	41	116	69	1	0.134	1.000	1.000
442	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ATF4(2), CACNA1C(18), CACNA1D(9), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(1), GNA11(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK9(2), MMP14(1), MMP2(7), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLD1(3), PLD2(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCD(5), PRKX(2), PTK2B(3), RAF1(4), SOS1(9), SOS2(7), SRC(4)	128842288	290	211	281	89	41	47	31	115	56	0	0.444	1.000	1.000
443	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(3), INPPL1(4), ITPK1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), OCRL(3), PI4KA(10), PI4KB(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3C3(4), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(6), PTEN(34), PTPMT1(2), SYNJ1(6), SYNJ2(6)	125629140	285	206	272	73	27	47	29	98	80	4	0.180	1.000	1.000
444	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(9), ACTN1(1), ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGEF6(4), ARHGEF7(5), BCAR1(6), BRAF(4), CDC42(1), CDKN2A(5), CSE1L(4), DOCK1(3), EPHB2(2), FYN(2), GRB2(2), GRB7(5), GRLF1(6), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGB3BP(1), MAP2K7(1), MAP3K11(2), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), P4HB(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CA(14), PIK3CB(5), PKLR(1), PLCG1(4), PLCG2(4), PTEN(34), PTK2(3), RAF1(4), RALA(2), RHO(1), ROCK1(5), ROCK2(4), SHC1(4), SOS1(9), SOS2(7), SRC(4), TLN1(14), TLN2(12), WAS(1), ZYX(1)	122144307	305	206	293	75	19	49	42	109	79	7	0.166	1.000	1.000
445	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADK(1), ADSL(3), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), ATP1B1(5), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G2(1), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), GART(4), GDA(3), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NPR1(4), NPR2(5), NT5M(2), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE6B(6), PDE6C(3), PDE7B(1), PDE8A(2), PDE9A(10), PFAS(3), PKLR(1), PKM2(1), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(3), RRM2(1)	127786456	279	204	267	56	32	36	32	103	76	0	0.0232	1.000	1.000
446	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ARHGAP5(6), BCAR1(6), CD99(2), CDC42(1), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), CXCR4(1), ESAM(3), EZR(2), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), GRLF1(6), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), ITK(2), JAM3(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(11), MMP2(7), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), MYLPF(3), NCF1(1), NCF2(1), NOX1(7), NOX3(6), OCLN(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(3), RAPGEF4(2), ROCK1(5), ROCK2(4), SIPA1(4), TXK(1), VAV1(4), VAV2(4), VAV3(1), VCAM1(6), VCL(2)	124181197	275	200	260	75	35	39	32	99	69	1	0.375	1.000	1.000
447	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(5), BUB1(2), CDKL1(1), CDKL2(4), CDS2(2), CLK1(5), CLK2(2), CLK4(5), COL4A3BP(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), NEK3(3), OCRL(3), PAK4(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CA(14), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4), PLK3(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKG1(4), RAF1(4), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KB1(2), STK11(3), TGFBR1(1), VRK1(1)	113730773	262	198	249	57	24	43	25	93	76	1	0.0355	1.000	1.000
448	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(4), CACNA1A(14), CRHR1(2), GNA11(1), GNA12(1), GNA13(4), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(8), GRIA2(4), GRIA3(2), GRID2(9), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), IGF1R(3), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), LYN(1), MAP2K2(1), MAPK3(3), NOS1(10), NOS3(4), NPR1(4), NPR2(5), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), RAF1(4), RYR1(23)	110431542	254	196	250	71	44	27	30	99	53	1	0.338	1.000	1.000
449	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCBP2(2), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CCRL1(2), CCRL2(1), CHML(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(3), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR77(1), GPR83(2), GPR85(3), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPY1R(2), NPY2R(2), NTSR1(3), OPN1SW(2), OPRD1(3), OPRK1(2), OPRM1(3), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR1Q1(1), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(2), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY6(2), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RHO(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(4), TRHR(2)	115924315	251	195	249	86	43	31	33	104	40	0	0.525	1.000	1.000
450	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(3), ACTN3(1), ACTN4(3), DES(1), DMD(13), FAM48A(1), MYBPC1(5), MYBPC2(4), MYBPC3(3), MYH3(7), MYH6(7), MYH7(13), MYH8(6), MYL1(4), MYL2(1), MYL9(1), MYOM1(6), NEB(23), TCAP(1), TMOD1(6), TNNI1(1), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(124), VIM(2)	140734031	245	194	239	75	23	42	28	99	49	4	0.588	1.000	1.000
451	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(9), ABL2(6), AKT1(3), AKT2(5), AKT3(3), ARAF(1), AREG(1), BAD(1), BRAF(4), BTC(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), CDKN1B(1), CRKL(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(8), ERBB4(11), GAB1(2), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(3), MAP2K2(1), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(2), NCK1(1), NCK2(2), NRAS(2), NRG1(6), NRG2(4), NRG3(5), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), RAF1(4), RPS6KB1(2), RPS6KB2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SRC(4), STAT5A(3), STAT5B(3), TGFA(1)	102262937	263	193	249	52	25	43	45	100	48	2	0.00456	1.000	1.000
452	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(3), AKT2(5), AKT3(3), BCL10(1), CARD11(10), CBL(3), CBLB(4), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(6), CHUK(2), CTLA4(3), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(3), IKBKB(3), IKBKG(1), IL4(1), ITK(2), JUN(2), KRAS(3), LAT(1), LCK(1), LCP2(3), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDCD1(1), PDK1(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCQ(5), PTPN6(3), PTPRC(8), RASGRP1(3), SOS1(9), SOS2(7), TEC(6), TNF(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	100777114	260	190	238	47	21	39	35	100	64	1	0.00759	1.000	1.000
453	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(7), AMY2A(1), AMY2B(2), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), G6PC(3), GAA(3), GANC(3), GBA(3), GBA3(3), GBE1(2), GCK(2), GPI(3), GUSB(7), GYS1(3), GYS2(3), HK1(5), IFIH1(4), MGAM(9), MOV10L1(6), NUDT5(4), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(4), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UXS1(1)	124157811	252	189	244	82	18	31	47	90	65	1	0.832	1.000	1.000
454	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(3), AKT2(5), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN1B(1), CDKN2A(5), CREB3(2), CREB5(3), ERBB4(11), F2RL2(2), GAB1(2), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), MET(22), MYC(2), NOLC1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARD3(6), PDK1(1), PIK3CA(14), PIK3CD(2), PPP1R13B(4), PREX1(8), PTEN(34), PTK2(3), PTPN1(2), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(9), SOS2(7), TSC1(6), TSC2(13), YWHAE(1)	75104622	236	186	218	45	21	35	38	71	65	6	0.00555	1.000	1.000
455	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(9), ATM(20), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDAN1(6), CDC14A(5), CDC14B(1), CDC20(3), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDH1(2), CDK2(2), CDK4(6), CDKN1A(3), CDKN2A(5), CHEK1(1), CHEK2(2), DTX4(5), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(16), ESPL1(13), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MPEG1(1), ORC1L(1), ORC2L(1), PCNA(4), PLK1(1), PRKDC(13), PTPRA(5), PTTG2(1), RB1(4), SKP2(1), SMAD4(3), TBC1D8(1), TP53(50), WEE1(2)	111101244	275	182	253	62	27	35	41	87	78	7	0.0201	1.000	1.000
456	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(7), AKAP3(3), AKAP4(3), AKAP5(1), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(22), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA11(1), GNA12(1), GNA13(4), GNA15(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(4), KRAS(3), NRAS(2), PALM2(1), PDE1A(1), PDE1B(5), PDE1C(2), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PLCB3(3), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKD3(4), SLC9A1(3), USP5(4)	117000085	254	182	247	71	26	37	16	103	71	1	0.501	1.000	1.000
457	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(10), ABCA10(6), ABCA12(16), ABCA13(23), ABCA2(4), ABCA3(4), ABCA4(11), ABCA5(10), ABCA6(5), ABCA7(11), ABCA8(6), ABCA9(3), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(8), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(10), ABCC10(7), ABCC11(7), ABCC12(4), ABCC2(4), ABCC3(11), ABCC4(7), ABCC5(7), ABCC6(7), ABCC8(5), ABCC9(5), ABCD1(3), ABCD2(2), ABCD3(2), ABCD4(4), ABCG1(1), ABCG2(2), ABCG4(7), ABCG5(3), ABCG8(5), CFTR(9), TAP1(1), TAP2(1)	118313684	252	182	241	77	16	43	36	102	54	1	0.484	1.000	1.000
458	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ASIP(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(10), CTNNB1(2), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(16), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KIT(3), KITLG(2), KRAS(3), LEF1(3), MAP2K2(1), MAPK3(3), MITF(5), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), POMC(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), TCF7L1(2), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	106042160	238	178	230	62	30	29	27	99	53	0	0.190	1.000	1.000
459	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(13), ARAF(1), ATF4(2), BRAF(4), CACNA1C(18), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(10), EP300(16), GRIA1(8), GRIA2(4), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRM1(5), GRM5(9), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R1A(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), RAP1A(1), RAPGEF3(3), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1)	100929497	230	173	216	58	31	33	25	89	50	2	0.139	1.000	1.000
460	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(2), CLK3(2), CLK4(5), COL2A1(6), CPSF1(4), CPSF2(2), CPSF3(5), CPSF4(2), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(7), DHX15(3), DHX16(2), DHX38(3), DHX8(3), DHX9(7), DICER1(4), FUS(6), GIPC1(3), LOC440563(2), LSM7(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(4), PHF5A(1), POLR2A(13), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4B(7), PRPF8(15), PSKH1(2), PTBP1(1), PTBP2(1), RBM17(3), RBM5(2), RNMT(4), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(16), SF3B2(5), SF3B4(1), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPA(1), SNRPB(3), SNRPB2(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(5), SUPT5H(9), TXNL4A(1), U2AF2(3), XRN2(4)	105751759	211	172	206	51	18	44	22	82	44	1	0.155	1.000	1.000
461	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG6(3), ALG8(2), ALG9(2), B3GNT1(2), B3GNT2(3), B3GNT6(4), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(2), CHST3(2), CHST4(1), CHST6(2), CHST7(2), CHSY1(9), DPAGT1(8), EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(4), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), NDST1(2), NDST2(4), NDST3(1), NDST4(7), OGT(5), RPN1(3), RPN2(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(6), XYLT1(5), XYLT2(2)	107807152	245	171	227	71	22	37	29	79	78	0	0.631	1.000	1.000
462	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(4), ACVR2B(1), ACVRL1(1), AMHR2(9), BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CHRD(5), CREBBP(10), CUL1(5), DCN(3), E2F5(1), EP300(16), GDF5(5), GDF6(2), GDF7(1), INHBA(2), INHBB(2), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(7), MAPK3(3), MYC(2), NODAL(2), NOG(2), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), RBL2(5), RBX1(1), ROCK1(5), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(2), SMAD3(2), SMAD4(3), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(1), SMURF2(4), SP1(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNF(1), ZFYVE16(1), ZFYVE9(7)	97460488	224	170	209	51	21	22	38	75	68	0	0.128	1.000	1.000
463	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(8), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C1S(17), C2(2), C3(8), C3AR1(3), C4BPA(3), C4BPB(3), C5(6), C5AR1(3), C6(3), C7(4), C8A(1), C8B(2), C8G(2), CD46(1), CD55(2), CD59(1), CFB(6), CFH(6), CFI(2), CPB2(6), CR1(8), CR2(4), F10(1), F11(2), F12(7), F13A1(3), F13B(4), F2(4), F2R(2), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), KNG1(4), MASP1(4), MASP2(1), MBL2(2), PLAT(4), PLAU(5), PLAUR(2), PLG(8), PROC(4), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(3), TFPI(2), THBD(1), VWF(15)	90044716	237	170	216	48	24	28	25	103	55	2	0.0214	1.000	1.000
464	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(7), BAD(1), CABIN1(11), CALM2(1), CAMK2B(1), CAMK4(3), CD3E(2), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(10), CSNK2A1(3), CSNK2B(1), CTLA4(3), EGR2(1), EGR3(2), EP300(16), FOS(1), GATA3(2), GATA4(2), GRLF1(6), GSK3A(3), GSK3B(3), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(3), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(3), MEF2D(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(8), OPRD1(3), P2RX7(2), PAK1(3), PPIA(1), PPP3CC(3), PTPRC(8), RELA(6), SFN(1), SLA(1), SP1(2), SP3(2), TNF(1), TRAF2(1), TRPV6(5), VAV1(4), VAV2(4), VAV3(1), XPO5(3)	89449954	211	161	199	50	20	25	32	72	60	2	0.186	1.000	1.000
465	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(10), CD19(1), CD1A(1), CD1B(1), CD1C(2), CD1D(3), CD1E(2), CD2(2), CD22(4), CD24(1), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(2), CD3G(2), CD4(10), CD44(3), CD5(1), CD55(2), CD59(1), CD8A(1), CR1(8), CR2(4), CSF1R(8), CSF2RA(5), CSF3R(4), DNTT(4), EPOR(3), FCER2(1), FCGR1A(2), FLT3(6), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(8), IL2RA(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL7R(1), IL9R(6), ITGA1(8), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(3), KIT(3), KITLG(2), MME(6), MS4A1(1), TFRC(3), THPO(1), TNF(1), TPO(4)	81530289	218	159	202	46	17	23	30	80	66	2	0.148	1.000	1.000
466	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BAX(1), BFAR(2), BTK(1), CAD(13), CASP10(4), CASP8(1), CASP8AP2(7), CSNK1A1(2), DAXX(6), DEDD(3), DFFA(1), DIABLO(1), EGFR(10), EPHB2(2), FAIM2(1), MAP2K7(1), MAP3K1(8), MAP3K5(5), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MET(22), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PFN2(1), PTPN13(9), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(6), TP53(50), TPX2(2), TRAF2(1)	72853538	201	157	180	38	23	24	22	75	53	4	0.00841	1.000	1.000
467	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(3), AKT2(5), AKT3(3), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IKBKB(3), IKBKE(3), IKBKG(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), RAC1(1), RELA(6), RIPK1(1), SPP1(3), STAT1(6), TBK1(3), TICAM1(3), TLR1(3), TLR2(2), TLR3(1), TLR4(3), TLR5(4), TLR6(2), TLR7(6), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2)	88541992	184	150	174	39	18	28	24	83	29	2	0.0375	1.000	1.000
468	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5E(3), INPPL1(4), IPMK(1), ITPK1(2), ITPKA(2), ITPKB(2), MINPP1(2), MIOX(2), OCRL(3), PI4KA(10), PI4KB(3), PIK3C3(4), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PTEN(34), PTPMT1(2), SYNJ1(6), SYNJ2(6)	73966672	187	149	176	46	14	27	19	61	62	4	0.303	1.000	1.000
469	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(2), BRAF(4), CHUK(2), DAXX(6), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP3K9(6), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAP4K5(4), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(2), MAPK6(1), MAPK7(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MKNK2(1), MYC(2), NFKB1(2), NFKBIA(2), PAK1(3), PAK2(4), RAC1(1), RAF1(4), RELA(6), RIPK1(1), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KB1(2), RPS6KB2(2), SHC1(4), SP1(2), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1)	95949060	201	147	189	45	20	20	23	77	57	4	0.215	1.000	1.000
470	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(20), CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), CREB3(2), CREB3L1(1), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(5), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MNAT1(1), MYC(2), MYT1(5), NACA(11), ORC1L(1), ORC2L(1), PCNA(4), POLE(5), POLE2(1), PRIM1(3), RB1(4), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(11), TP53(50), WEE1(2)	75493313	211	146	187	39	22	23	24	66	70	6	0.00789	1.000	1.000
471	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(3), AKT2(5), AKT3(3), BCL10(1), BLNK(1), BTK(1), CARD11(10), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), IKBKG(1), INPP5D(2), JUN(2), KRAS(3), LILRB3(5), LYN(1), MALT1(3), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(4), VAV2(4), VAV3(1)	73996460	174	146	159	41	18	26	18	70	42	0	0.161	1.000	1.000
472	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(3), AKT2(5), AKT3(3), CAMKK1(4), CAMKK2(3), CD36(1), CHUK(2), CPT1A(2), CPT1C(4), CPT2(2), G6PC(3), IKBKB(3), IKBKG(1), IRS1(5), IRS4(1), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NPY(1), PCK1(5), PCK2(2), POMC(2), PPARGC1A(4), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKCQ(5), PTPN11(2), RELA(6), RXRB(4), RXRG(2), SLC2A1(2), SLC2A4(3), SOCS3(1), STAT3(3), STK11(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TYK2(7)	81118222	184	143	165	45	14	24	29	67	49	1	0.254	1.000	1.000
473	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGAP1(1), ARHGEF11(5), BTK(1), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(7), ITPR2(13), ITPR3(5), LIMK1(7), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(4), PTEN(34), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(4), SAG(4), WASF1(1), WASL(7)	70183324	174	139	165	33	14	36	19	53	49	3	0.0114	1.000	1.000
474	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(5), AKT3(3), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(3), MAP2K2(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NOS3(4), NRAS(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCA(2), PRKCG(6), PTGS2(5), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D2A(3), SHC2(4), SPHK1(2), SPHK2(1), SRC(4)	71174711	175	138	163	47	16	29	23	71	36	0	0.316	1.000	1.000
475	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(5), AKT3(3), BCR(2), BTK(1), CD19(1), CDKN2A(5), DAPP1(2), FLOT1(1), FLOT2(1), GAB1(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), PDK1(1), PHF11(2), PIK3CA(14), PITX2(2), PLCG2(4), PPP1R13B(4), PREX1(8), PTEN(34), PTPRC(8), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SAG(4), SYK(2), TEC(6), VAV1(4)	55409321	158	136	148	31	9	27	20	49	49	4	0.0200	1.000	1.000
476	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(5), AKT3(3), BTK(1), FCER1G(1), FYN(2), GAB2(2), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(3), LAT(1), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(2), PDK1(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PRKCA(2), PRKCD(5), PRKCE(4), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SOS1(9), SOS2(7), SYK(2), TNF(1), VAV1(4), VAV2(4), VAV3(1)	72031924	155	135	146	44	14	31	23	64	23	0	0.277	1.000	1.000
477	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), INPP5D(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), MAP4K1(5), MAPK3(3), NFATC1(4), NFATC2(8), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), PPP3CA(3), PPP3CC(3), PTPRC(8), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4)	73169256	165	133	154	35	16	27	25	56	41	0	0.0356	1.000	1.000
478	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(4), ADAM17(2), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(2), CSK(4), CXCL1(1), EGFR(10), F11R(1), GIT1(4), IGSF5(5), IKBKB(3), IKBKG(1), JAM3(1), JUN(2), LYN(1), MAP3K14(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(22), NFKB1(2), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(3), PLCG1(4), PLCG2(4), PTPN11(2), PTPRZ1(15), RAC1(1), RELA(6), SRC(4), TCIRG1(2), TJP1(6)	70863498	164	129	151	43	15	23	22	68	34	2	0.454	1.000	1.000
479	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(3), BAD(1), BAK1(1), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(5), BIRC5(1), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(3), HELLS(4), IKBKB(3), IKBKG(1), IRF2(2), IRF5(3), IRF6(6), IRF7(1), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFSF10(9), TP53(50), TP73(4), TRADD(2), TRAF2(1), TRAF3(1)	56615232	168	128	149	35	13	24	24	51	52	4	0.0446	1.000	1.000
480	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(2), APH1A(1), CREBBP(10), CTBP1(2), CTBP2(3), DLL1(1), DLL3(1), DLL4(2), DTX1(5), DTX3(1), DTX3L(2), DTX4(5), DVL1(1), DVL2(1), EP300(16), HDAC1(2), JAG1(9), JAG2(4), MAML1(9), MAML2(6), MAML3(10), NCOR2(7), NCSTN(2), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), NUMB(3), NUMBL(1), PSEN2(3), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(8), SNW1(3)	66065555	168	127	157	79	15	20	21	52	56	4	1.000	1.000	1.000
481	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY4(3), ADCY6(2), ADCY8(13), CACNA1A(14), CACNA1B(5), GNAS(5), GNB1(3), GNB3(2), GNG3(1), GRM4(6), ITPR3(5), KCNB1(2), PDE1A(1), PLCB2(4), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), SCNN1A(4), SCNN1B(4), SCNN1G(2), TAS1R1(2), TAS1R2(9), TAS1R3(3), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R14(1), TAS2R16(1), TAS2R3(14), TAS2R38(4), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R43(8), TAS2R46(2), TAS2R50(2), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3)	56606413	153	127	142	36	33	15	17	59	29	0	0.0885	1.000	1.000
482	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), GCDH(3), HADH(1), HADHA(4), HSD17B4(2), NSD1(13), OGDH(8), OGDHL(2), PIPOX(3), PLOD1(3), PLOD2(5), PLOD3(11), RDH11(4), RDH13(1), SETD1A(8), SETD7(1), SETDB1(8), SHMT1(2), SHMT2(5), SPCS1(3), SUV39H2(5), TMLHE(1)	56859555	160	126	147	32	11	26	21	56	45	1	0.0659	1.000	1.000
483	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(2), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(3), JUN(2), MAP2K5(4), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK10(2), MAPK7(4), MAPK9(2), MYEF2(1), NFATC3(7), NR2C2(1), PAPPA(4), SHC1(4), TP53(50), TRAF6(2), ZAK(4)	49795709	154	125	140	31	12	19	19	58	41	5	0.0384	1.000	1.000
484	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(3), ENTPD6(2), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(7), RFC5(3), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP1(2), UPP2(2), UPRT(3)	81728932	155	124	145	38	12	24	18	53	46	2	0.248	1.000	1.000
485	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(6), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(1), ATP5G2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), COX10(5), COX15(3), COX17(1), COX5A(1), COX6A2(1), COX6B2(1), COX7A1(2), COX7A2(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB10(1), NDUFB11(1), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFC1(2), NDUFS1(7), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), PPA2(2), SDHA(9), SDHB(1), SDHD(2), TCIRG1(2), UQCRC1(1), UQCRC2(2), UQCRFS1(2)	55948858	139	120	137	37	13	18	24	57	26	1	0.339	1.000	1.000
486	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), FPGS(3), GGH(2), IFIH1(4), MOV10L1(6), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SKIV2L2(2), SMARCA2(5), SMARCA5(4)	62195910	143	119	140	42	10	26	28	46	32	1	0.330	1.000	1.000
487	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(2), ALG6(3), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CELSR1(18), CELSR2(9), CELSR3(10), CHRM2(6), CHRM3(3), CIDEB(2), EMR2(4), EMR3(9), F2R(2), FSHR(2), GPR116(5), GPR133(7), GPR135(2), GPR17(2), GPR18(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(4), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(10), LTB4R2(1), NTSR1(3), OR8G1(2), OR8G2(2), P2RY13(1), PTGFR(5), SMO(4), SSTR2(2), TSHR(2)	64070642	151	118	145	48	23	21	17	59	31	0	0.604	1.000	1.000
488	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(3), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(3), APOA1(1), APOA2(1), APOA5(2), AQP7(10), CD36(1), CPT1A(2), CPT1C(4), CPT2(2), CYP27A1(1), CYP4A11(5), CYP4A22(2), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(3), HMGCS2(1), ILK(4), LPL(3), ME1(1), MMP1(2), NR1H3(3), PCK1(5), PCK2(2), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(3), SLC27A1(4), SLC27A2(1), SLC27A5(3), SLC27A6(7), SORBS1(3), UBC(4), UCP1(1)	64574096	152	118	135	46	12	20	17	65	37	1	0.741	1.000	1.000
489	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(2), CANX(2), CD4(10), CD74(1), CD8A(1), CIITA(5), CTSB(4), CTSL1(3), CTSS(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC1(3), KLRC2(5), KLRC3(1), LTA(1), NFYA(1), NFYC(2), PSME2(3), RFX5(2), RFXAP(1), TAP1(1), TAP2(1)	43001311	156	118	148	52	8	26	17	63	40	2	0.914	1.000	1.000
490	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(18), B3GALT4(1), CDR1(4), DGKI(1), FAU(3), IL6ST(6), PIGK(1), RPL10(1), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22(3), RPL23(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(3), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS19(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(4)	51762032	132	117	124	34	9	13	26	47	35	2	0.438	1.000	1.000
491	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1E(3), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(2), GLI1(7), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(25), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), PTCH1(11), PTCH2(2), SHH(3), SMO(4), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1), ZIC2(1)	57935422	140	116	129	41	18	18	14	52	38	0	0.696	1.000	1.000
492	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(2), ETS2(1), ETV6(2), FMN2(9), GRB2(2), KRAS(3), MAPK3(3), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), PIWIL1(2), PIWIL2(2), PIWIL3(4), PIWIL4(3), RAF1(4), SOS1(9), SOS2(7), SPIRE1(1), SPIRE2(2)	50297264	134	113	130	37	21	15	20	47	28	3	0.458	1.000	1.000
493	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA1(1), APOA2(1), CD36(1), CITED2(1), CREBBP(10), EHHADH(6), EP300(16), FABP1(3), HSD17B4(2), INS(1), JUN(2), LPL(3), MAPK3(3), ME1(1), MRPL11(1), MYC(2), NCOA1(4), NCOR1(7), NCOR2(7), NFKBIA(2), NR1H3(3), NR2F1(1), NRIP1(7), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PTGS2(5), RB1(4), RELA(6), SP1(2), SRA1(1), STAT5A(3), STAT5B(3), TNF(1)	62570772	147	112	133	47	8	25	18	54	39	3	0.788	1.000	1.000
494	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AGK(6), AGPAT1(1), AGPAT6(1), AKR1A1(2), AKR1B1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CEL(3), DAK(3), DGAT1(2), DGAT2(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), GK(1), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(7), LIPA(1), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PNPLA3(3), PPAP2B(1), PPAP2C(3)	58826635	126	108	123	32	14	18	18	46	30	0	0.222	1.000	1.000
495	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(3), ATF1(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), CREBBP(10), CRKL(1), DAG1(3), EGR1(10), EGR2(1), EGR3(2), EGR4(1), ELK1(1), FRS2(2), JUN(2), MAP1B(12), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NTRK1(8), PIK3C2G(5), PIK3CA(14), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(4), SRC(4), TH(4)	50743771	129	108	115	32	16	29	15	40	28	1	0.134	1.000	1.000
496	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(4), ACSS2(7), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GALM(3), GAPDH(4), GAPDHS(5), GCK(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	57844581	129	106	119	35	11	9	19	44	44	2	0.613	1.000	1.000
497	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ABP1(5), ACAT1(1), ACMSD(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP1A1(1), CYP1A2(4), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(3), HAAO(2), HADH(1), HADHA(4), HSD17B4(2), KYNU(3), LCMT1(1), LCMT2(4), LNX1(1), MAOA(2), MAOB(2), METTL2B(1), NFX1(3), OGDH(8), OGDHL(2), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), TPH1(2), TPH2(2), WARS(1), WARS2(4)	60265649	124	105	117	30	10	20	23	44	27	0	0.165	1.000	1.000
498	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(3), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(5), LMNB1(3), LMNB2(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), NFKB1(2), NFKBIA(2), NUMA1(7), PAK2(4), PRKCD(5), PRKDC(13), PSEN2(3), PTK2(3), RASA1(7), RB1(4), RELA(6), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	69400667	134	104	131	39	6	26	19	42	38	3	0.565	1.000	1.000
499	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(10), EEF1A2(3), EEF1B2(3), EEF1D(2), EEF1G(2), EEF2(2), EEF2K(4), EIF1AX(1), EIF2AK1(5), EIF2AK2(4), EIF2AK3(3), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G3(7), EIF5(3), EIF5A(2), EIF5B(2), ETF1(3), GSPT2(1), KIAA0664(3), PABPC1(18), PABPC3(17), PAIP1(3), SLC35A4(2)	43920888	124	103	118	38	15	23	21	38	24	3	0.448	1.000	1.000
500	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), AXIN1(5), CCND2(1), CSNK1E(3), CTNNB1(2), DVL1(1), DVL2(1), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LDLR(3), MAPK10(2), MAPK9(2), MYC(2), PAFAH1B1(1), PLAU(5), PPP2R5C(3), PPP2R5E(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), RAC1(1), SFRP4(2), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT5B(2), WNT7B(1)	57268066	118	103	114	31	15	17	11	42	33	0	0.276	1.000	1.000
501	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), MYST3(4), MYST4(3), PNPLA3(3), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(2), TH(4), TPO(4), TYR(5), TYRP1(4)	58823389	123	102	119	29	13	12	18	48	32	0	0.266	1.000	1.000
502	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(3), BAK1(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(3), IKBKG(1), JUN(2), MAP3K1(8), MAP3K14(2), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), PARP1(5), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1)	37121383	124	101	109	30	7	20	17	36	40	4	0.223	1.000	1.000
503	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(5), AKT3(3), ASAH1(3), BRAF(4), DAG1(3), DRD2(1), EGFR(10), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PI3(1), PIK3CB(5), PITX2(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), RAF1(4), RGS20(1), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT3(3)	58297991	127	101	125	30	13	19	22	47	25	1	0.123	1.000	1.000
504	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(4), CYP1B1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(6), EPHX1(6), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	57730669	123	100	119	35	15	11	20	46	31	0	0.549	1.000	1.000
505	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT6(1), CDS2(2), CHAT(5), CHKB(2), CHPT1(3), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), ESCO1(2), ESCO2(1), ETNK1(3), ETNK2(1), GPAM(5), GPD1(1), GPD1L(3), GPD2(1), LCAT(5), LYPLA1(1), MYST3(4), MYST4(3), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PNPLA3(3), PPAP2B(1), PPAP2C(3), PTDSS1(2), SH3GLB1(3)	65536580	117	94	112	31	16	15	15	39	32	0	0.313	1.000	1.000
506	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(3), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(2), TPH1(2), WARS(1), WARS2(4)	54712976	122	94	115	31	16	16	16	51	23	0	0.234	1.000	1.000
507	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(3), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GBGT1(2), GCNT2(22), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	47664340	118	93	96	31	14	15	11	31	46	1	0.660	1.000	1.000
508	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(5), BLVRA(1), COX10(5), COX15(3), CP(4), CPOX(6), EPRS(5), FECH(2), FTMT(5), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UROD(2)	42004357	104	92	96	31	10	9	17	42	26	0	0.722	1.000	1.000
509	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2A(1), AMY2B(2), ENPP1(4), ENPP3(2), G6PC(3), GAA(3), GBA3(3), GBE1(2), GCK(2), GPI(3), GUSB(7), GYS1(3), GYS2(3), HK1(5), MGAM(9), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UXS1(1)	57501205	109	92	104	35	11	10	19	40	29	0	0.780	1.000	1.000
510	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM2(1), ELK1(1), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP2K7(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PAK2(4), PIK3CA(14), PIK3R1(5), PLA2G4A(2), PLCG1(4), PPP3CA(3), PPP3CC(3), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4)	42262344	104	91	96	30	10	18	11	36	29	0	0.573	1.000	1.000
511	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(2), ETS2(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), JUN(2), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(3), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), RAF1(4), RELA(6), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(1)	48453273	108	90	102	27	14	11	5	41	36	1	0.584	1.000	1.000
512	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7)	50890196	111	87	110	49	13	23	23	31	21	0	0.971	1.000	1.000
513	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7)	50890196	111	87	110	49	13	23	23	31	21	0	0.971	1.000	1.000
514	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), BCR(2), CAPN1(3), CRKL(1), CSK(4), FYN(2), GRB2(2), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAPK3(3), PPP1R12B(2), PTK2(3), PXN(3), RAF1(4), RAP1A(1), ROCK1(5), SHC1(4), SOS1(9), SRC(4), TLN1(14), VCL(2), ZYX(1)	46700891	100	87	99	27	8	14	8	45	24	1	0.566	1.000	1.000
515	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(2), MAOB(2), NOS1(10), NOS3(4), OAT(2), ODC1(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(3), SMS(2)	43864785	96	86	94	28	8	7	20	35	25	1	0.618	1.000	1.000
516	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), CEL(3), DGAT1(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), GK(1), GLA(1), GLB1(5), LCT(7), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PPAP2B(1), PPAP2C(3)	48269350	102	86	99	30	14	15	13	35	25	0	0.488	1.000	1.000
517	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(2), AGXT2(2), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), MAOA(2), MAOB(2), PISD(2), PLCB2(4), PLCG1(4), PLCG2(4), SARDH(5), SARS(3), SHMT1(2), SHMT2(5), TARS(6)	41967764	96	86	92	26	10	14	18	31	22	1	0.347	1.000	1.000
518	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(3), AKT2(5), AKT3(3), ARHGEF11(5), CDC42(1), DLG4(2), GNA13(4), IKBKG(1), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(5), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RDX(2), ROCK1(5), ROCK2(4), SRF(1), TBXA2R(4)	48951973	101	86	97	30	13	12	12	42	22	0	0.590	1.000	1.000
519	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), GPI(3), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	48536050	103	85	95	32	10	5	15	38	34	1	0.836	1.000	1.000
520	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), GPI(3), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	48536050	103	85	95	32	10	5	15	38	34	1	0.836	1.000	1.000
521	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), F10(1), F11(2), F12(7), F2(4), F2R(2), F5(12), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), PROC(4), PROS1(5), SERPING1(3)	44687494	96	85	94	30	12	17	10	34	22	1	0.482	1.000	1.000
522	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS(6), CARS2(3), DARS(3), DARS2(1), EPRS(5), FARSA(2), HARS(1), HARS2(1), IARS(4), IARS2(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), MTFMT(1), NARS2(6), PARS2(3), QARS(1), RARS(3), RARS2(2), SARS(3), SARS2(1), TARS(6), TARS2(7), VARS(4), VARS2(6), WARS(1), WARS2(4), YARS(1), YARS2(1)	53298830	103	84	97	29	3	16	11	47	26	0	0.607	1.000	1.000
523	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GAPDHS(5), GCK(2), GOT1(3), GOT2(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), TNFAIP1(1), TPI1(2)	41944124	100	83	95	29	6	8	14	28	43	1	0.711	1.000	1.000
524	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(2), CDK2(2), CDT1(2), DIAPH2(2), MCM10(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), NACA(11), ORC1L(1), ORC2L(1), PCNA(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), PRIM1(3), RFC1(6), RFC2(1), RFC4(2), RFC5(3), RPA1(2), RPA2(1), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(4)	50721121	99	82	90	30	11	10	11	36	31	0	0.759	1.000	1.000
525	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(2), F12(7), F13B(4), F2(4), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), LPA(9), PLAT(4), PLAU(5), PLG(8), SERPINB2(1), SERPINF2(2), VWF(15)	34880438	97	81	93	33	9	9	16	35	26	2	0.771	1.000	1.000
526	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPS(5), CDS2(2), CHAT(5), CHKB(2), CLC(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), ETNK1(3), GPD1(1), GPD2(1), LCAT(5), LGALS13(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G4A(2), PLA2G6(5), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1), PPAP2C(3)	49908150	95	81	91	27	15	16	10	29	25	0	0.346	1.000	1.000
527	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), CYP19A1(2), HSD11B2(1), HSD17B1(1), HSD17B2(1), HSD17B7(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	49477840	89	80	89	26	7	7	19	29	27	0	0.559	1.000	1.000
528	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(4), ACSS2(7), ACYP1(1), AKR1B1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1)	46455859	93	79	89	26	5	12	18	24	32	2	0.634	1.000	1.000
529	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(1), ACTR2(2), AKT1(3), CDC42(1), CFL1(1), CFL2(1), FLNA(6), FLNC(10), FSCN1(4), FSCN2(1), FSCN3(2), GDI2(2), LIMK1(7), MYH2(9), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PFN2(1), RHO(1), ROCK1(5), ROCK2(4), WASF1(1), WASL(7)	46819765	96	79	93	31	9	21	5	31	30	0	0.740	1.000	1.000
530	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), AKT1(3), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), MAPK3(3), NR1I3(1), PAK1(3), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CA(14), PIK3CD(2), PIK3R1(5)	48967400	88	79	83	25	8	19	10	37	14	0	0.370	1.000	1.000
531	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MIOX(2), OCRL(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CA(14), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4)	45078568	90	77	83	26	6	14	7	40	23	0	0.694	1.000	1.000
532	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(2), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR77(1), GRPR(2), MC2R(3), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TACR1(2), TACR2(2), TACR3(2), TRHR(2), TSHR(2)	50346108	93	77	93	34	18	11	12	39	13	0	0.641	1.000	1.000
533	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(3), APC(9), ASAH1(3), CAMP(1), CAV3(1), DAG1(3), DLG4(2), EPHB2(2), GNAI1(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PITX2(2), RAC1(1), RHO(1), RYR1(23)	45473864	82	77	82	20	14	11	15	29	13	0	0.160	1.000	1.000
534	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(3), CBX3(1), CLOCK(4), CRY1(1), EIF4G2(4), ETV6(2), GSTP1(2), HERPUD1(3), HSPA8(8), IDI1(1), KLF9(2), MYF6(3), NCKAP1(3), NCOA4(7), NR1D2(2), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(2), PSMA4(2), SF3A3(2), TOB1(5), TUBB3(3), UGP2(1), ZFR(8)	36283558	86	76	85	28	4	12	17	32	19	2	0.747	1.000	1.000
535	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(2), ALOX15B(3), ALOX5(4), CBR1(4), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(5), CYP4A22(2), CYP4F2(4), CYP4F3(2), DHRS4(3), EPHX2(1), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	38801290	84	76	81	21	10	9	18	31	15	1	0.225	1.000	1.000
536	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CREBBP(10), EP300(16), ERCC3(4), GRIP1(3), GTF2A1(2), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), NCOR2(7), NRIP1(7), PELP1(1), POLR2A(13), SRA1(1), TBP(1)	46262931	85	75	81	45	6	10	14	31	24	0	0.998	1.000	1.000
537	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), KHK(8), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(2), RDH11(4), RDH13(1), SORD(10), TPI1(2)	37171158	81	75	74	21	11	8	13	24	25	0	0.458	1.000	1.000
538	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(5), AKT3(3), ANKRD6(2), APC(9), AXIN1(5), AXIN2(1), CER1(1), CSNK1A1(2), CTNNB1(2), DACT1(2), DKK2(1), DVL1(1), FSTL1(2), GSK3A(3), GSK3B(3), LRP1(15), MVP(5), NKD1(4), NKD2(4), PTPRA(5), SENP2(1), WIF1(5)	40007373	84	75	79	21	7	12	12	31	22	0	0.283	1.000	1.000
539	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(8), ACACB(5), ACADM(1), ACAT1(1), ACSS1(4), ACSS2(7), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2)	39835717	83	73	78	22	4	10	22	23	22	2	0.415	1.000	1.000
540	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(9), AR(5), ESR2(4), ESRRA(1), HNF4A(2), NR1D2(2), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(1), NR2F2(4), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(5), PPARD(1), PPARG(2), RARA(4), RARB(3), RARG(1), RORA(3), RORC(2), RXRB(4), RXRG(2), THRA(2), VDR(2)	40701245	77	73	76	26	10	13	16	27	11	0	0.612	1.000	1.000
541	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4)	37521064	82	72	79	26	9	11	9	27	26	0	0.792	1.000	1.000
542	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CKB(1), CKMT1B(1), CPS1(6), DAO(1), EPRS(5), GATM(2), GLUD2(7), GOT1(3), GOT2(2), LAP3(4), NOS1(10), NOS3(4), OAT(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(3), PRODH(4), PYCR1(1), PYCR2(1), RARS(3), RARS2(2)	35757050	81	72	79	23	8	6	17	32	18	0	0.502	1.000	1.000
543	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(3), ACAT1(1), ACSM1(3), AKR1B10(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADH(1), HADHA(4), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), ILVBL(3), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(3), PRDX6(2), RDH11(4), RDH13(1)	40674438	77	71	73	23	9	11	14	27	16	0	0.517	1.000	1.000
544	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), BAX(1), BCL2A1(2), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKE(3), LTA(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(8), PTPN13(9), RIPK1(1), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	43389187	78	69	77	20	5	14	15	30	14	0	0.312	1.000	1.000
545	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(4), CASP7(1), CASP8(1), CFLAR(1), DAXX(6), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), PTPN13(9), RB1(4), RIPK2(4), SPTAN1(12)	42361490	82	69	82	25	6	9	12	29	23	3	0.739	1.000	1.000
546	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1)	33890354	77	69	74	23	11	8	6	29	23	0	0.749	1.000	1.000
547	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(3), ASAH1(3), GNAI1(2), GNB1(3), ITGAV(1), ITGB3(3), MAPK3(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLCB1(4), PRKCA(2), PTK2(3), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(2), SRC(4)	27332016	72	68	66	21	8	18	6	27	13	0	0.444	1.000	1.000
548	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(2), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(5), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(6)	32403597	74	68	70	27	6	8	16	25	19	0	0.860	1.000	1.000
549	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(4), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), ILK(4), MNAT1(1), POLR1A(6), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(2), TAF7(2), TBP(1)	35228221	74	68	69	21	5	7	8	30	24	0	0.655	1.000	1.000
550	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG5(2), ALG6(3), ALG8(2), ALG9(2), B4GALT1(1), B4GALT3(2), DOLPP1(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), RFT1(2), RPN1(3), RPN2(1), ST6GAL1(1), STT3B(4)	42113922	82	67	81	20	4	19	4	28	27	0	0.347	1.000	1.000
551	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ACAT1(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1)	36714968	75	66	72	21	4	9	14	22	25	1	0.617	1.000	1.000
552	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), RB1(4), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	39344213	74	65	74	25	3	10	12	24	22	3	0.835	1.000	1.000
553	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SGMS1(1), SGPP1(2), SGPP2(2), SMPD1(6), SMPD2(3), SMPD4(2), SPHK1(2), SPHK2(1), SPTLC1(1), SPTLC2(2), UGT8(2)	34445146	74	64	70	25	13	13	7	25	16	0	0.635	1.000	1.000
554	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GANC(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH13(1), UGP2(1)	38163708	70	62	69	27	10	8	9	24	19	0	0.911	1.000	1.000
555	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(1), ADCY3(7), ADCY9(7), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1D(1), ATP6V1G1(1), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(4), PLCG2(4), PRKCA(2), SEC61B(2), TRIM23(5)	36995340	68	61	66	26	5	7	9	30	17	0	0.958	1.000	1.000
556	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CXCR4(1), GNAI1(2), GNB1(3), HRAS(1), MAPK3(3), NFKB1(2), PIK3C2G(5), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PTK2B(3), PXN(3), RAF1(4), RELA(6)	27999113	67	60	58	24	4	15	7	24	15	2	0.893	1.000	1.000
557	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BID(2), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFA(1), DFFB(1), GAS2(4), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(9), TRADD(2), TRAF2(1)	33337320	69	60	63	18	3	9	11	24	21	1	0.527	1.000	1.000
558	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(3), MRPL13(1), MRPS7(2), RPL10A(2), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS7(1), RPS8(1), RPS9(1), RPSA(1)	22043805	63	59	63	17	5	6	11	26	14	1	0.570	1.000	1.000
559	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(1), CRKL(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(4), MAP3K1(8), MAPK14(1), MAPK3(3), PAK1(3), PLCG1(4), PRKCA(2), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1)	28336172	65	59	64	21	5	12	4	27	16	1	0.853	1.000	1.000
560	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(2), BLNK(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK3(3), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(8), RPS6KA3(3), SHC1(4), SOS1(9), SYK(2), VAV1(4), VAV2(4), VAV3(1)	31619373	66	59	61	18	6	11	8	24	16	1	0.457	1.000	1.000
561	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(3), ITGA1(8), ITGB1(7), ITGB3(3), PTK2(3), PXN(3), RAC1(1), SPTAN1(12), SRC(4), TLN1(14)	28528464	64	59	63	20	5	9	5	27	18	0	0.775	1.000	1.000
562	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(2), ELK1(1), FOS(1), IKBKB(3), IKBKG(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TLR10(3), TLR2(2), TLR3(1), TLR4(3), TLR6(2), TLR7(6), TLR9(1), TRAF6(2)	36225584	63	57	59	18	6	10	4	24	17	2	0.632	1.000	1.000
563	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), GCK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), KHK(8), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(2), SORD(10), TPI1(2)	23916050	61	56	54	19	6	4	10	17	24	0	0.862	1.000	1.000
564	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(10), BAIAP2(2), CASP1(3), CASP7(1), CASP8(1), GAPDH(4), INS(1), INSR(6), MAGI1(5), MAGI2(6), RERE(10), WWP1(8), WWP2(4)	23569036	61	56	52	24	8	4	7	21	19	2	0.992	1.000	1.000
565	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(2), CDC42(1), CREB3(2), CREB5(3), DUSP10(1), EEF2K(4), EIF4E(2), ELK1(1), IL1R1(3), MAP2K3(4), MAP2K6(1), MAP3K10(4), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), SRF(1), TRAF6(2)	33387178	62	56	62	19	6	11	4	30	10	1	0.541	1.000	1.000
566	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(4), CPOX(6), EPRS(5), FECH(2), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UROD(2)	27378863	60	55	54	18	5	5	12	21	17	0	0.684	1.000	1.000
567	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(3), BAD(1), BAX(1), CSF2RB(5), IGF1R(3), IL3(1), KIT(3), KITLG(2), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	21684365	54	53	49	18	8	9	4	25	8	0	0.595	1.000	1.000
568	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(1), GNAI1(2), GNB1(3), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), PLA2G4A(2), PLCB1(4), PRKCA(2), PTGS1(2), PTK2(3), RAF1(4), SRC(4), SYK(2), TBXAS1(4)	24358796	58	53	57	18	6	8	9	18	16	1	0.686	1.000	1.000
569	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(2), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), NOS1(10), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), SYT1(1)	25363665	56	51	55	20	10	9	4	24	9	0	0.713	1.000	1.000
570	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(10), EP300(16), NCOA3(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RARA(4)	20453810	52	50	49	18	3	4	8	23	14	0	0.773	1.000	1.000
571	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), CFL1(1), GNAS(5), GNB1(3), HRAS(1), LIMK1(7), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2(3), RAF1(4), ROCK2(4)	25512537	54	50	49	14	5	7	7	20	15	0	0.673	1.000	1.000
572	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKM(3), PFKP(3), PGM1(1)	32229810	55	50	54	24	7	6	6	18	18	0	0.978	1.000	1.000
573	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(6), DARS(3), EPRS(5), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), QARS(1), RARS(3), SARS(3), TARS(6), WARS(1), WARS2(4), YARS(1)	32235504	58	49	53	16	1	6	8	26	17	0	0.685	1.000	1.000
574	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(1), CAPN2(4), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(8), PPP3CA(3), PPP3CC(3), PRKCA(2), SYT1(1)	23801443	56	49	51	19	8	4	4	21	19	0	0.884	1.000	1.000
575	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2F1(1), NCOA1(4), NCOA2(11), NCOA3(8), NCOR2(7), POLR2A(13), RARA(4), TBP(1)	24972585	58	48	51	29	6	6	8	17	21	0	0.985	1.000	1.000
576	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(1), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SMPD1(6), SMPD2(3), SPTLC1(1), SPTLC2(2)	23445985	51	46	50	18	9	7	4	20	11	0	0.739	1.000	1.000
577	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(2), ASRGL1(4), CA1(1), CA13(2), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUD2(7), GLUL(2), HAL(1)	21102099	47	46	42	15	2	6	6	25	8	0	0.724	1.000	1.000
578	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(3), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(7), GSK3A(3), GSK3B(3), LYN(1), PFKL(3), PFKM(3), PFKP(3), PLCG1(4), PRKCE(4), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(4)	25044969	51	46	48	18	3	7	10	18	13	0	0.843	1.000	1.000
579	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), ASAH1(3), CAMP(1), CERK(6), CREB3(2), CREB5(3), DAG1(3), EPHB2(2), FOS(1), ITPKA(2), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2)	27735983	48	44	45	16	8	4	8	14	14	0	0.801	1.000	1.000
580	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), P4HB(2), SLC23A1(7), SLC23A2(2), SLC2A1(2), SLC2A3(2)	25533935	47	44	47	18	4	12	5	17	8	1	0.733	1.000	1.000
581	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), DRD1(1), DRD2(1), DRD3(3), DRD5(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2)	24622013	48	43	46	25	8	4	3	23	10	0	0.971	1.000	1.000
582	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(2), CASP2(1), CHUK(2), IKBKB(3), IKBKG(1), JUN(2), LTA(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	24269862	46	43	43	15	4	6	2	19	14	1	0.906	1.000	1.000
583	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), HSD11B2(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4)	27033091	46	42	46	14	4	3	11	12	16	0	0.535	1.000	1.000
584	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), CSK(4), CTNNA1(7), CTNNA2(8), CTNNB1(2), PTK2(3), PXN(3), SRC(4), VCL(2)	19060330	44	42	44	17	8	6	6	17	6	1	0.826	1.000	1.000
585	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(8), DDX20(7), E2F1(1), ETS1(2), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(5), SIN3A(4), SIN3B(3)	26135928	45	42	45	13	7	5	4	17	12	0	0.545	1.000	1.000
586	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(2), IKBKB(3), IKBKG(1), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K14(2), MAP3K7(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	24297343	48	42	45	15	5	11	3	11	16	2	0.706	1.000	1.000
587	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(2), CD33(2), CD5(1), IFNA1(2), IFNB1(3), IL3(1), IL4(1), ITGAX(8), TLR2(2), TLR4(3), TLR7(6), TLR9(1)	18230793	42	40	41	14	5	6	11	14	6	0	0.575	1.000	1.000
588	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(3), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B2(1), PLA2G4A(2), PTGDR(2), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), PTGS1(2), PTGS2(5), TBXAS1(4)	20337800	42	40	42	20	5	4	8	15	9	1	0.953	1.000	1.000
589	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(3), BIRC3(5), CASP8(1), CFLAR(1), IKBKG(1), JUN(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	26674377	42	39	42	15	4	8	7	18	4	1	0.658	1.000	1.000
590	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT6(1), AGPS(5), CHPT1(3), ENPP2(3), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PPAP2B(1), PPAP2C(3)	23345073	42	38	39	18	7	4	5	17	9	0	0.894	1.000	1.000
591	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX5(4), CYP1A2(4), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH13(1)	23945609	39	37	38	16	6	3	4	18	8	0	0.824	1.000	1.000
592	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(7), GALNT2(3), GALNT4(1), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(6)	14590676	38	36	35	22	3	2	7	12	14	0	0.998	1.000	1.000
593	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(14), PIK3R1(5), PLCB1(4), PLCG1(4), PRKCA(2), VAV1(4)	12929470	36	35	30	11	3	10	4	12	7	0	0.550	1.000	1.000
594	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(3), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2), VNN1(1)	17126387	36	34	36	12	3	4	5	14	10	0	0.769	1.000	1.000
595	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUL(2), HAL(1)	18914320	34	33	34	11	1	5	4	20	4	0	0.747	1.000	1.000
596	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(4), ILVBL(3), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(4), VARS2(6)	17577080	36	32	36	11	2	7	6	12	9	0	0.531	1.000	1.000
597	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(5), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNB1(3), LMNB2(1), PRF1(1)	19078382	34	31	34	12	0	8	7	12	7	0	0.765	1.000	1.000
598	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(5), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	15890797	31	31	31	12	4	0	0	17	10	0	0.860	1.000	1.000
599	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(4), LCT(7), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	16040691	34	31	34	12	5	6	2	13	8	0	0.671	1.000	1.000
600	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(10), EP300(16), MAPK3(3), PELP1(1), SRC(4)	14702121	34	31	31	15	2	6	6	10	10	0	0.906	1.000	1.000
601	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(7), JAK2(7), JAK3(4), MAPK3(3), STAT3(3), TYK2(7)	11689003	31	31	30	10	2	0	8	12	9	0	0.848	1.000	1.000
602	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(5), KHK(8), LCT(7), MPI(2), PGM1(1), PYGL(2), PYGM(4), TPI1(2)	13537100	31	30	31	11	8	1	6	12	4	0	0.628	1.000	1.000
603	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(2), PSMD11(4), PSMD12(1), PSMD13(2), PSMD2(5), PSMD6(2)	16157887	33	30	32	11	3	3	4	8	15	0	0.833	1.000	1.000
604	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), NPAS2(1), PER1(6), PER2(6), PER3(6)	16900305	30	30	28	13	4	2	7	10	6	1	0.904	1.000	1.000
605	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(5), FASN(9), MCAT(2), OLAH(2), OXSM(3)	15626713	29	29	29	10	3	7	5	10	4	0	0.543	1.000	1.000
606	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST12(2), CHST14(1), CHST3(2), CHST7(2), CHSY1(9), DSE(1), UST(1), XYLT1(5), XYLT2(2)	12755299	31	29	25	11	5	6	0	9	11	0	0.774	1.000	1.000
607	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1)	13352507	28	28	25	10	2	2	3	14	7	0	0.891	1.000	1.000
608	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), EIF4E(2), FBL(1), GPT(4), LDHB(2), LDHC(3), MAPK14(1), NCL(6)	8935488	29	27	28	10	0	1	11	9	8	0	0.859	1.000	1.000
609	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(1), BNIP1(1), GOSR1(1), SEC22B(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(1), STX19(1), STX2(2), STX4(2), STX5(1), STX7(2), STX8(1), TSNARE1(3), USE1(1), VAMP1(1), VAMP2(1), VTI1A(1)	16806685	28	26	28	11	4	4	4	13	3	0	0.706	1.000	1.000
610	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(4), ITPKA(2), PDE1A(1), PDE1B(5), PLCB1(4), PLCB2(4), TRH(8)	10973760	28	26	21	10	6	2	0	7	13	0	0.929	1.000	1.000
611	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(6), SRC(4), UBQLN1(3)	12058520	26	25	26	12	2	5	6	10	2	1	0.892	1.000	1.000
612	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(5), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(2)	8054820	22	22	20	10	2	2	3	10	5	0	0.912	1.000	1.000
613	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(5), CPOX(6), FECH(2), PPOX(2), UROD(2)	7692088	22	22	17	10	1	1	3	7	10	0	0.962	1.000	1.000
614	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(4), PRKCA(2), PTK2B(3), SYT1(1)	13655108	18	16	17	11	2	4	2	6	4	0	0.984	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(2)	2083524	5	5	5	3	0	2	1	2	0	0	0.875	1.000	1.000
616	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1622802	2	2	2	3	0	0	2	0	0	0	0.974	1.000	1.000
