rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(12)	306695	12	12	11	3	10	1	1	0	0	0	0.131	0.257	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(5)	219519	5	5	5	1	5	0	0	0	0	0	0.373	0.377	1.000
3	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(6), TAT(21)	1124647	33	21	32	9	24	3	2	1	3	0	0.0125	0.914	1.000
4	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(8), SNAP25(9), VAMP2(1)	1396359	23	21	21	4	16	1	0	3	3	0	0.00233	0.958	1.000
5	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	708066	5	5	4	1	3	0	0	2	0	0	0.339	0.976	1.000
6	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(2)	659766	4	3	4	0	0	2	0	1	1	0	0.334	0.983	1.000
7	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(7), CD3E(2), CD3G(1)	480032	10	7	10	4	8	0	0	0	2	0	0.405	0.993	1.000
8	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(14), ALDOC(4), TPI1(1)	1685752	24	19	21	7	17	2	0	2	3	0	0.0344	0.998	1.000
9	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(6), FOSB(6), GRIA2(43), JUND(1), PPP1R1B(2)	1573577	58	50	55	22	35	3	2	9	9	0	0.114	0.998	1.000
10	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	6	CHRM1(5), GNAQ(6), GNB1(1), PLCB1(61), TUB(10)	2651089	83	55	75	29	64	2	2	7	8	0	0.00646	0.999	1.000
11	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), SLPI(6)	734750	15	14	15	7	7	1	0	6	1	0	0.587	0.999	1.000
12	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(3), CASP3(3), CASP8(9), CFL1(2), CFLAR(5), PDE6D(2)	1669286	24	22	23	9	10	3	3	5	3	0	0.370	0.999	1.000
13	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RELA(4)	3497971	88	61	79	28	66	3	3	8	8	0	0.00919	1.000	1.000
14	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(7), DCN(19), FMOD(6), KERA(16), LUM(12)	1512551	60	45	56	25	46	5	3	3	3	0	0.0224	1.000	1.000
15	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(7), ALDH1A2(16), BCMO1(17), RDH5(2)	1670003	42	35	36	13	29	2	1	4	6	0	0.0148	1.000	1.000
16	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(8), SEC61A2(2), SRP19(3), SRP54(4), SRP68(8), SRP72(1), SRP9(1), SRPR(4)	3260943	31	29	26	7	17	0	1	6	7	0	0.0870	1.000	1.000
17	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(34), GNAS(33), GNB1(1), PRKACA(3), PRKAR1A(3)	2790154	74	51	70	24	46	11	4	7	6	0	0.0123	1.000	1.000
18	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(5), ACADM(5), ACADS(6), ECHS1(3), HADHA(6)	2335984	25	24	25	9	15	4	1	4	1	0	0.330	1.000	1.000
19	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1)	2847454	21	18	21	6	5	2	2	4	6	2	0.329	1.000	1.000
20	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(4)	1438077	9	9	9	5	6	0	0	1	2	0	0.721	1.000	1.000
21	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(9), HLA-DRA(13), HLA-DRB1(5)	1006636	29	24	27	15	23	0	0	3	3	0	0.197	1.000	1.000
22	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(16), CCND1(2), CCNE1(4), CCNE2(6), CDK2(1), CDK4(8), CDKN1B(2), E2F1(6), E2F2(5), E2F4(3), PRB1(14)	3587410	67	52	61	20	44	1	4	13	5	0	0.0346	1.000	1.000
23	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(14), LPL(6), NR3C1(7), PPARG(12), RETN(3), RXRA(4), TNF(1)	2489206	47	40	44	17	29	7	0	6	5	0	0.0415	1.000	1.000
24	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(3), CCR3(11), CSF2(2), HLA-DRA(13), HLA-DRB1(5), IL3(3), IL5(4)	1295425	41	29	39	20	33	1	0	4	3	0	0.0602	1.000	1.000
25	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(6), MMP14(3), MMP2(9), MMP9(8), RECK(11), TIMP1(4), TIMP2(2), TIMP3(5), TIMP4(7)	3182420	55	43	53	19	29	4	3	10	9	0	0.0610	1.000	1.000
26	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), CYCS(1), GPD2(3), SDHA(4), SDHC(5), SDHD(2), UQCRC1(4)	2839542	21	18	21	7	13	1	1	4	1	1	0.268	1.000	1.000
27	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3)	3395939	63	48	58	21	36	7	4	9	7	0	0.0100	1.000	1.000
28	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3)	3395939	63	48	58	21	36	7	4	9	7	0	0.0100	1.000	1.000
29	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(2), MYC(5), SP1(5), SP3(1), WT1(10)	2678875	25	21	24	7	14	4	3	1	3	0	0.123	1.000	1.000
30	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(5), PRKCA(9), TGM2(11)	2124288	30	24	29	13	22	2	1	0	5	0	0.0628	1.000	1.000
31	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1942316	11	9	11	9	3	3	1	1	3	0	0.916	1.000	1.000
32	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(2), CDK2(1), CDK4(8), CDKN1A(3), CDKN1B(2), CFL1(2), E2F1(6), E2F2(5), MDM2(4), NXT1(2), PRB1(14)	2999618	49	43	44	17	27	4	2	10	6	0	0.0953	1.000	1.000
33	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3), NDUFA12(1), NDUFA13(4)	1700209	16	16	15	8	12	2	1	0	1	0	0.586	1.000	1.000
34	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(19), NR0B2(6), NR1H3(5), NR1H4(14), RXRA(4)	2322057	48	35	48	18	31	7	3	5	2	0	0.0359	1.000	1.000
35	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(3), IDI1(1), SQLE(4)	1354168	9	9	9	5	4	1	1	3	0	0	0.710	1.000	1.000
36	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6)	2409018	95	71	78	31	77	4	5	6	3	0	0.00551	1.000	1.000
37	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), MIOX(7), UGDH(1)	3615161	58	46	55	21	33	7	6	5	7	0	0.0290	1.000	1.000
38	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), TYR(11)	4128130	77	53	74	23	49	6	2	5	15	0	0.0127	1.000	1.000
39	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(2), DAG1(9), GNAQ(6), ITPKB(11)	2566827	28	24	26	12	20	0	2	2	4	0	0.164	1.000	1.000
40	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2)	2947162	28	23	28	8	15	5	1	4	3	0	0.226	1.000	1.000
41	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(16), GAD1(14), HDC(25), PNMT(4), TH(11), TPH1(12)	2549058	82	61	77	32	63	5	3	1	10	0	0.00163	1.000	1.000
42	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(13), IARS(10), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1)	4290028	67	51	63	20	45	6	2	7	7	0	0.0552	1.000	1.000
43	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(4), EPO(5), FLT3(38), IGF1(11), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(10), TGFB1(2), TGFB2(4), TGFB3(3)	3515566	93	63	87	34	55	6	6	14	12	0	0.0101	1.000	1.000
44	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(4), PAPSS2(5), SULT1A2(3), SULT1E1(16), SULT2A1(9), SUOX(4)	2605387	41	25	39	14	28	1	0	4	8	0	0.110	1.000	1.000
45	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHB(2), LDHC(7), MPST(2)	2934593	39	31	37	16	28	2	6	2	1	0	0.171	1.000	1.000
46	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), KARS(4)	2952936	21	19	21	8	17	0	0	2	2	0	0.449	1.000	1.000
47	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(3), CSF1(12), IL6(2), LDLR(19), LPL(6)	2287921	42	29	41	20	26	7	2	6	1	0	0.259	1.000	1.000
48	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3), YARS2(2)	3720330	69	50	66	29	44	7	2	5	11	0	0.0529	1.000	1.000
49	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(4), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(3)	2140316	31	25	30	17	14	6	3	3	5	0	0.291	1.000	1.000
50	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BAD(4), BCAR1(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN2(6), CAV1(1), CAV3(2), CCND1(2), CCND2(7), CCND3(2), CDC42(2), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), CRK(3), CRKL(2), CTNNB1(17), DIAPH1(10), DOCK1(17), EGF(22), EGFR(26), ELK1(3), ERBB2(10), FARP2(7), FIGF(5), FLNA(23), FLNB(45), FLNC(69), FLT1(42), FN1(28), FYN(8), GRB2(2), GSK3B(3), HGF(30), HRAS(6), IBSP(9), IGF1(11), IGF1R(15), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), JUN(1), KDR(57), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), MAP2K1(18), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(5), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(9), PRKCG(17), PTK2(7), PXN(2), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF1(14), RELN(90), RHOA(3), ROCK1(6), ROCK2(14), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(55), TNR(84), TNXB(126), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCL(9), VEGFA(5), VEGFB(3), VTN(9), VWF(60), ZYX(8)	156458284	3604	269	3426	1600	2524	253	106	308	388	25	1.80e-08	1.000	1.000
51	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(19), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), C5AR1(10), CALCR(19), CALCRL(19), CCKAR(12), CCKBR(14), CGA(1), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(13), CNR2(6), CRHR1(9), CRHR2(5), CTSG(5), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2(13), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHB(9), FSHR(21), GABBR1(9), GABBR2(12), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GABRB1(16), GABRB2(26), GABRB3(25), GABRD(5), GABRE(25), GABRG1(38), GABRG2(20), GABRG3(10), GABRP(16), GABRQ(12), GABRR1(10), GALR1(5), GALR3(2), GH1(5), GH2(11), GHR(43), GHRHR(12), GHSR(11), GIPR(4), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(16), GNRHR(3), GPR156(15), GPR35(6), GPR50(19), GPR63(9), GPR83(14), GRIA1(52), GRIA2(43), GRIA3(27), GRIA4(26), GRID1(27), GRID2(60), GRIK1(30), GRIK2(31), GRIK3(35), GRIK4(16), GRIK5(12), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRIN3A(50), GRIN3B(5), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM6(32), GRM7(45), GRM8(50), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HRH4(6), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LEP(4), LEPR(31), LHB(1), LHCGR(29), LTB4R(1), LTB4R2(1), MAS1(4), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), MCHR1(4), MCHR2(21), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPBWR1(3), NPBWR2(12), NPFFR1(1), NPFFR2(15), NPY1R(29), NPY2R(13), NPY5R(25), NR3C1(7), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), P2RY1(5), P2RY10(7), P2RY13(4), P2RY14(8), P2RY2(10), P2RY4(2), P2RY6(2), P2RY8(9), PARD3(20), PRL(3), PRLHR(1), PRLR(38), PRSS1(26), PRSS3(7), PTAFR(2), PTGDR(12), PTGER2(7), PTGER3(11), PTGER4(3), PTGFR(21), PTGIR(5), PTH2R(18), RXFP1(19), RXFP2(25), SCTR(8), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SSTR5(4), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), THRA(2), THRB(18), TRHR(24), TRPV1(4), TSHB(7), TSHR(8), UTS2R(1), VIPR1(8), VIPR2(7)	92963633	2951	261	2714	1781	2032	253	102	267	281	16	5.09e-13	1.000	1.000
52	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(9), ACTG1(7), CHAD(4), COL11A1(80), COL11A2(51), COL17A1(29), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), DES(9), DSC1(58), DSC2(46), DSC3(50), DSG1(64), DSG2(26), DSG3(68), DSG4(70), FN1(28), GJA1(10), GJA10(18), GJA3(1), GJA4(4), GJA5(11), GJA8(20), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(7), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(12), ITGB4(22), KRT1(22), KRT10(14), KRT12(11), KRT13(13), KRT14(3), KRT15(10), KRT16(10), KRT17(4), KRT18(4), KRT19(3), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(14), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(15), KRT33A(6), KRT33B(4), KRT34(12), KRT35(11), KRT36(18), KRT37(13), KRT38(10), KRT39(16), KRT4(22), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(14), KRT7(5), KRT71(18), KRT72(11), KRT73(18), KRT74(16), KRT75(16), KRT76(17), KRT77(15), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(7), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(4), NES(25), PRPH(1), RELN(90), SPP1(7), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VIM(6), VTN(9), VWF(60)	106337368	3242	260	3064	1417	2373	233	79	224	315	18	1.02e-10	1.000	1.000
53	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), DAG1(9), FN1(28), FNDC1(44), FNDC3A(12), FNDC4(5), FNDC5(3), GP5(6), GP6(7), GP9(6), HMMR(5), HSPG2(31), IBSP(9), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), RELN(90), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SPP1(7), SV2A(17), SV2B(27), SV2C(22), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VTN(9), VWF(60)	95453432	2584	258	2464	1108	1866	161	80	180	278	19	9.37e-05	1.000	1.000
54	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY7(13), ADCY8(54), ADCY9(11), ADORA2A(3), ADORA2B(1), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), AGTR1(10), ATP2A1(13), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), ATP2B4(17), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BST1(2), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CCKAR(12), CCKBR(14), CD38(6), CHRM1(5), CHRM2(26), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(12), EDNRB(7), EGFR(26), ERBB2(10), ERBB3(7), ERBB4(59), F2R(8), GNA11(9), GNA14(7), GNA15(7), GNAL(2), GNAQ(6), GNAS(33), GRIN1(11), GRIN2A(107), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), GRPR(7), HRH1(15), HRH2(3), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), LHCGR(29), LTB4R2(1), MYLK(48), MYLK2(13), NOS1(77), NOS3(20), NTSR1(8), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), PDE1A(44), PDE1B(15), PDE1C(54), PDGFRA(32), PDGFRB(23), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTAFR(2), PTGER3(11), PTGFR(21), PTK2B(12), RYR1(114), RYR2(99), RYR3(96), SLC25A6(2), SLC8A1(35), SLC8A2(14), SLC8A3(46), SPHK1(2), SPHK2(8), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), TNNC1(2), TNNC2(5), TRHR(24), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1)	113096253	2866	256	2691	1775	1998	208	103	228	307	22	1.07e-05	1.000	1.000
55	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(2), ACTN1(8), ACTN2(21), ACTN4(5), APC(27), APC2(12), ARAF(5), ARHGEF1(2), ARHGEF12(13), ARHGEF4(7), ARHGEF6(11), ARHGEF7(5), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), ARPC5(1), BAIAP2(8), BCAR1(5), BDKRB1(6), BDKRB2(10), CD14(6), CDC42(2), CFL1(2), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(2), CSK(1), CYFIP1(8), CYFIP2(27), DIAPH1(10), DIAPH2(9), DIAPH3(20), DOCK1(17), EGF(22), EGFR(26), EZR(7), F2(13), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FN1(28), GIT1(6), GNA12(3), GNA13(1), GSN(8), HRAS(6), IQGAP1(10), IQGAP2(29), IQGAP3(13), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), KRAS(7), LIMK1(5), LIMK2(12), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(24), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), NCKAP1(5), NCKAP1L(44), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PFN4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(10), PTK2(7), PXN(2), RAC2(2), RAF1(12), RDX(4), RHOA(3), ROCK1(6), ROCK2(14), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(4), TIAM1(28), TIAM2(28), VAV1(19), VAV2(5), VAV3(11), VCL(9), WAS(8), WASF1(5), WASF2(6), WASL(4)	116093151	1992	256	1907	1050	1283	155	74	244	224	12	0.00617	1.000	1.000
56	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	243	ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(4), ARRB2(8), ATF2(6), ATF4(9), BDNF(6), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CACNA2D1(17), CACNA2D2(16), CACNA2D3(61), CACNA2D4(26), CACNB1(4), CACNB2(15), CACNB3(3), CACNB4(14), CACNG1(4), CACNG2(11), CACNG3(25), CACNG4(4), CACNG5(13), CACNG6(6), CACNG7(7), CACNG8(1), CASP3(3), CD14(6), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(3), DUSP1(1), DUSP10(9), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(4), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(22), EGFR(26), ELK1(3), ELK4(6), FAS(5), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FLNA(23), FLNB(45), FLNC(69), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), JUN(1), JUND(1), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(10), MAX(2), MEF2C(5), MKNK1(7), MKNK2(4), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(12), NFATC4(18), NFKB1(6), NFKB2(5), NLK(5), NR4A1(4), NTF3(7), NTRK1(16), NTRK2(11), PAK1(4), PAK2(9), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PPM1A(3), PPM1B(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PPP5C(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTPN5(13), PTPN7(4), PTPRR(30), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(5), RASA2(15), RASGRF1(22), RASGRF2(24), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KA6(21), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(5), STMN1(3), TAOK1(11), TAOK2(28), TAOK3(4), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4), ZAK(8)	119068559	2287	255	2187	1341	1485	214	72	220	279	17	0.292	1.000	1.000
57	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(2), ACVR1B(3), ACVR2A(5), ACVR2B(3), AMHR2(15), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(7), CCL1(3), CCL11(3), CCL14(3), CCL15(3), CCL16(2), CCL18(1), CCL2(3), CCL20(2), CCL21(2), CCL22(2), CCL23(2), CCL24(3), CCL25(2), CCL26(3), CCL27(2), CCL28(1), CCL7(6), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CD27(3), CD40(4), CD40LG(1), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(8), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), CX3CL1(5), CX3CR1(17), CXCL10(3), CXCL11(1), CXCL12(8), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(6), EDA(2), EDA2R(4), EDAR(9), EGF(22), EGFR(26), EPO(5), EPOR(1), FAS(5), FASLG(15), FLT1(42), FLT3(38), FLT3LG(1), FLT4(31), GDF5(16), GH1(5), GH2(11), GHR(43), HGF(30), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL15(4), IL15RA(6), IL17A(8), IL17B(4), IL17RA(5), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL1RAP(3), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL25(1), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), INHBA(20), INHBB(9), INHBC(13), INHBE(5), KDR(57), KIT(13), KITLG(10), LEP(4), LEPR(31), LIF(3), LIFR(39), LTA(5), LTB(3), MET(23), MPL(9), NGFR(8), OSM(5), OSMR(40), PDGFB(6), PDGFC(17), PDGFRA(32), PDGFRB(23), PF4V1(1), PLEKHO2(5), PPBP(6), PRL(3), PRLR(38), RELT(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(11), TNFRSF14(3), TNFRSF17(7), TNFRSF18(5), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFRSF4(5), TNFRSF6B(2), TNFRSF8(19), TNFRSF9(4), TNFSF10(10), TNFSF11(5), TNFSF12(1), TNFSF13B(3), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(49), TSLP(2), VEGFA(5), VEGFB(3), XCL1(1), XCL2(2), XCR1(7)	74935173	1848	253	1759	963	1283	137	49	162	215	2	0.000306	1.000	1.000
58	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(15), ABLIM1(15), ABLIM2(10), ABLIM3(8), ARHGEF12(13), CDC42(2), CDK5(6), CFL1(2), CXCL12(8), CXCR4(3), DCC(102), DPYSL2(4), DPYSL5(15), EFNA1(1), EFNA2(1), EFNA4(4), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(34), EPHA4(22), EPHA5(7), EPHA6(78), EPHA7(54), EPHA8(24), EPHB1(31), EPHB2(36), EPHB3(17), EPHB4(15), EPHB6(26), FES(8), FYN(8), GNAI1(2), GNAI2(6), GNAI3(2), GSK3B(3), HRAS(6), ITGB1(7), KRAS(7), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(50), MAPK1(4), MAPK3(3), MET(23), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NGEF(13), NRP1(24), NTN4(19), NTNG1(15), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(10), PLXNA3(17), PLXNB1(23), PLXNB2(17), PLXNB3(7), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTK2(7), RAC2(2), RASA1(5), RGS3(19), RHOA(3), RHOD(2), RND1(6), ROBO1(25), ROBO2(47), ROBO3(19), ROCK1(6), ROCK2(14), SEMA3A(15), SEMA3C(4), SEMA3D(15), SEMA3E(31), SEMA3F(12), SEMA3G(15), SEMA4A(9), SEMA4B(5), SEMA4C(13), SEMA4D(10), SEMA4F(8), SEMA4G(8), SEMA5A(17), SEMA5B(21), SEMA6A(10), SEMA6B(8), SEMA6C(9), SEMA6D(7), SEMA7A(4), SLIT1(16), SLIT2(66), SLIT3(63), SRGAP1(7), SRGAP2(9), SRGAP3(40), UNC5A(13), UNC5B(12), UNC5C(19), UNC5D(37)	82813689	1777	249	1660	924	1213	146	51	172	186	9	0.00187	1.000	1.000
59	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), ANXA6(6), ARRB1(4), ARRB2(8), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1S(54), CACNB1(4), CACNB3(3), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CASQ1(8), CASQ2(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(10), GJA4(4), GJA5(11), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(9), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), ITPR1(36), ITPR2(20), ITPR3(12), KCNB1(37), KCNJ3(21), KCNJ5(13), MIB1(6), NME7(5), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SLC8A3(46), USP5(8), YWHAB(1), YWHAQ(3)	79216903	1717	241	1617	1165	1170	150	72	133	183	9	0.313	1.000	1.000
60	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(4), ASH1L(37), CASK(6), CDC42(2), CDK4(8), CGN(10), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTTN(5), EPB41(9), EPB41L1(16), EPB41L2(21), EPB41L3(7), EXOC3(6), EXOC4(12), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), HCLS1(15), HRAS(6), IGSF5(12), INADL(43), JAM2(11), JAM3(3), KRAS(7), LLGL1(5), LLGL2(16), MAGI1(38), MAGI2(24), MAGI3(12), MLLT4(17), MPDZ(13), MPP5(1), MRAS(2), MYH1(103), MYH10(14), MYH11(31), MYH13(55), MYH14(24), MYH15(64), MYH2(100), MYH3(31), MYH4(100), MYH6(40), MYH7(58), MYH7B(26), MYH8(66), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), OCLN(6), PARD3(20), PARD6A(1), PARD6B(2), PARD6G(4), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), RAB3B(1), RHOA(3), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(16), TJP2(11), TJP3(20), VAPA(2), YES1(4), ZAK(8)	81814957	1629	240	1516	1023	1090	143	45	161	180	10	0.520	1.000	1.000
61	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(5), ACTN2(21), ACTN4(5), DES(9), DMD(41), MYBPC1(29), MYBPC2(21), MYBPC3(16), MYH3(31), MYH6(40), MYH7(58), MYH8(66), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(130), TNNC2(5), TNNI2(2), TNNI3(3), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(7), TPM2(3), TPM3(2), TPM4(3), TTN(1335), VIM(6)	56716050	1910	238	1744	817	1402	131	65	165	125	22	7.84e-09	1.000	1.000
62	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(7), CADM1(5), CADM3(19), CD2(29), CD22(26), CD226(6), CD274(1), CD276(8), CD28(2), CD34(4), CD4(9), CD40(4), CD40LG(1), CD58(1), CD6(12), CD80(4), CD8A(2), CD8B(9), CD99(1), CDH1(6), CDH15(10), CDH2(16), CDH4(40), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(29), CNTN2(16), CNTNAP1(12), CNTNAP2(94), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(45), ITGA6(12), ITGA8(39), ITGA9(15), ITGAL(27), ITGAM(25), ITGAV(11), ITGB1(7), ITGB2(17), ITGB7(7), ITGB8(19), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(15), MPZ(5), MPZL1(2), NCAM1(18), NCAM2(11), NEGR1(9), NEO1(16), NFASC(52), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(60), NRXN2(20), NRXN3(35), OCLN(6), PDCD1(4), PDCD1LG2(3), PTPRC(36), PTPRF(35), PTPRM(8), PVR(2), PVRL1(4), PVRL2(8), PVRL3(5), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SELE(33), SELL(12), SELP(38), SELPLG(11), SIGLEC1(34), SPN(5), VCAM1(17), VCAN(44)	62115124	1445	236	1363	711	981	108	54	153	144	5	7.49e-05	1.000	1.000
63	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADM(1), ARRB1(4), ARRB2(8), ATF1(5), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(15), ATP2A3(15), CACNB3(3), CALCA(4), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CNN1(9), CNN2(3), CORIN(29), CREB3(1), CRH(4), CRHR1(9), DGKZ(9), ETS2(8), FOS(2), GABPA(6), GABPB2(8), GBA2(2), GJA1(10), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(33), IGFBP1(3), IGFBP2(2), IGFBP3(3), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(13), NFKB1(6), NOS1(77), NOS3(20), OXTR(6), PDE4B(9), PDE4D(8), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(5), PLCG1(9), PLCG2(30), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RLN1(2), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SP1(5), TNXB(126), USP5(8), YWHAB(1), YWHAQ(3)	73876879	1476	234	1399	860	1020	120	53	109	167	7	0.00581	1.000	1.000
64	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(16), CCND1(2), CCND2(7), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(8), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), EP300(19), EPO(5), EPOR(1), GH1(5), GH2(11), GHR(43), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL13RA2(6), IL15(4), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), IRF9(8), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), LIF(3), LIFR(39), MPL(9), MYC(5), OSM(5), OSMR(40), PIAS1(7), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIM1(1), PRL(3), PRLR(38), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(6), SPRED2(4), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), STAM(6), STAM2(3), STAT1(5), STAT2(6), STAT3(11), STAT4(26), STAT5A(3), STAT5B(5), STAT6(9), TPO(49), TSLP(2), TYK2(9)	61933245	1194	232	1148	574	774	98	39	131	150	2	0.0210	1.000	1.000
65	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CCRL2(6), CHML(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(16), CNR1(13), CNR2(6), CX3CR1(17), CXCR3(4), CXCR4(3), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(10), GPR37L1(7), GPR4(5), GPR50(19), GPR6(7), GPR63(9), GPR83(14), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LHCGR(29), LTB4R(1), MAS1(4), MC1R(1), MC3R(8), MC4R(1), MC5R(8), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OR10A5(10), OR11A1(6), OR12D3(9), OR1C1(14), OR1F1(9), OR1Q1(6), OR2H1(12), OR5V1(12), OR7A5(2), OR7C1(3), OR8B8(14), OXTR(6), P2RY1(5), P2RY10(7), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(10), P2RY6(2), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), RGR(8), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SUCNR1(10), TBXA2R(5), TRHR(24)	51252604	1318	228	1228	976	893	135	48	138	101	3	0.000301	1.000	1.000
66	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(27), APC2(12), AXIN1(10), AXIN2(5), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CCND1(2), CCND2(7), CCND3(2), CER1(18), CHD8(30), CREBBP(24), CSNK1A1(5), CSNK1A1L(7), CSNK1E(5), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTBP2(6), CTNNB1(17), CTNNBIP1(1), CUL1(3), DAAM1(8), DAAM2(7), DKK1(3), DKK2(19), DKK4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), FBXW11(6), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LEF1(4), LRP5(21), LRP6(14), MAP3K7(1), MAPK10(9), MAPK8(3), MAPK9(4), MMP7(4), MYC(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKD1(9), NKD2(7), NLK(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRICKLE1(11), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PSEN1(3), RAC2(2), RHOA(3), ROCK1(6), ROCK2(14), RUVBL1(1), SENP2(9), SFRP1(4), SFRP2(9), SFRP4(6), SFRP5(1), SMAD2(5), SMAD3(4), SMAD4(2), SOX17(8), TBL1X(4), TBL1XR1(3), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(8), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6)	67919409	1012	225	969	499	642	88	44	110	122	6	0.0359	1.000	1.000
67	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(16), EGF(22), EGFR(26), GJA1(10), GJD2(5), GNA11(9), GNAI1(2), GNAI2(6), GNAI3(2), GNAQ(6), GNAS(33), GRB2(2), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), HTR2A(11), HTR2B(2), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K5(5), MAP3K2(8), MAPK1(4), MAPK3(3), MAPK7(4), NPR1(17), NPR2(21), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), PRKX(3), RAF1(12), SOS1(10), SOS2(13), SRC(2), TJP1(16), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12)	55449196	1148	222	1064	628	780	90	44	108	121	5	0.00113	1.000	1.000
68	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(24), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BAD(4), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(16), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(3), EXOC7(8), FASN(26), FBP1(3), FBP2(2), FLOT1(2), FOXO1(6), G6PC(6), G6PC2(3), GCK(16), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(6), IKBKB(4), INPP5D(39), INSR(23), IRS1(5), IRS2(3), IRS4(11), KRAS(7), LIPE(10), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MKNK1(7), MKNK2(4), PCK1(28), PCK2(6), PDE3A(30), PDE3B(6), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PKLR(14), PPARGC1A(26), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R3A(64), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(3), PRKX(3), PTPN1(4), PTPRF(35), PYGB(3), PYGL(9), PYGM(14), RAF1(12), RAPGEF1(14), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(4), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SLC2A4(8), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(16), SOS1(10), SOS2(13), SREBF1(5), TRIP10(7), TSC1(9), TSC2(14)	67283197	1080	222	1027	539	705	94	40	113	124	4	0.0163	1.000	1.000
69	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADK(5), ADSL(6), ADSS(2), ADSSL1(9), AK1(1), AK2(3), AK5(11), AK7(27), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(2), GART(10), GDA(16), GMPR(2), GMPR2(2), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NPR1(17), NPR2(21), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(13), PDE11A(20), PDE1A(44), PDE1C(54), PDE2A(17), PDE3B(6), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PDE9A(13), PFAS(12), PKLR(14), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4), RRM2B(2), XDH(61)	69521955	1220	221	1159	616	833	97	54	113	121	2	0.000624	1.000	1.000
70	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(20), AMY2A(7), AMY2B(14), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(3), ENPP1(13), ENPP3(15), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), G6PC(6), G6PC2(3), GAA(8), GANC(6), GBA(7), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), IFIH1(10), MGAM(190), MOV10L1(25), NUDT5(1), NUDT8(2), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), RAD54B(8), RUVBL2(5), SETX(19), SI(94), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(4), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UXS1(6)	52325225	1111	219	1015	485	768	86	44	84	126	3	1.73e-05	1.000	1.000
71	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(32), BDKRB1(6), BDKRB2(10), C1QA(6), C1QB(7), C1QC(10), C1R(17), C1S(20), C2(9), C3(55), C3AR1(6), C4BPA(16), C4BPB(6), C5(23), C5AR1(10), C6(72), C7(49), C8B(47), C8G(1), C9(22), CD46(1), CD55(6), CD59(1), CFB(51), CFH(51), CFI(18), CPB2(1), CR1(53), CR2(36), F10(10), F11(14), F12(1), F13A1(26), F13B(35), F2(13), F2R(8), F3(2), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), KNG1(15), MASP1(20), MASP2(11), MBL2(14), PLAT(5), PLAU(3), PLAUR(4), PLG(36), PROC(11), PROS1(17), SERPINA1(10), SERPINA5(10), SERPINC1(7), SERPIND1(5), SERPINE1(6), SERPINF2(7), SERPING1(14), TFPI(8), THBD(2), VWF(60)	37951820	1214	218	1136	522	856	79	51	110	109	9	7.13e-05	1.000	1.000
72	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(25), CD14(6), CD19(8), CD1A(14), CD1B(14), CD1C(28), CD1D(10), CD1E(29), CD2(29), CD22(26), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD44(5), CD5(8), CD55(6), CD59(1), CD7(2), CD8A(2), CD8B(9), CR1(53), CR2(36), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF3(4), CSF3R(11), DNTT(10), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(38), FLT3LG(1), GP5(6), GP9(6), GYPA(10), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL2RA(7), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL7(5), IL7R(37), IL9R(9), ITGA1(23), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGAM(25), ITGB3(25), KIT(13), KITLG(10), MME(25), MS4A1(8), TFRC(4), THPO(10), TNF(1), TPO(49)	34627332	1003	217	931	469	697	53	36	83	129	5	0.000556	1.000	1.000
73	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(5), CACNA1A(38), CRH(4), CRHR1(9), GNA11(9), GNA12(3), GNA13(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GNAZ(7), GRIA1(52), GRIA2(43), GRIA3(27), GRID2(60), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), IGF1(11), IGF1R(15), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), LYN(11), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), NOS1(77), NOS3(20), NPR1(17), NPR2(21), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), RAF1(12), RYR1(114)	45780662	1207	216	1100	639	839	81	37	106	134	10	6.10e-05	1.000	1.000
74	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(4), AKT3(3), BCAR1(5), CAPN1(5), CAPN10(8), CAPN11(10), CAPN2(6), CAPN3(9), CAPN5(6), CAPN6(14), CAPN7(2), CAPN9(12), CAPNS1(3), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(8), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(17), MAPK6(8), MAPK7(4), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PDPK1(5), PIK3R2(6), PTK2(7), PXN(2), RAC2(2), RAP1B(1), RAPGEF1(14), RHO(2), ROCK1(6), ROCK2(14), SDCCAG8(3), SEPP1(13), SHC1(2), SHC3(15), SORBS1(16), SOS1(10), SRC(2), TLN1(12), TNS1(11), VASP(3), VAV2(5), VAV3(11), VCL(9), ZYX(8)	56385265	918	215	882	470	590	72	36	122	94	4	0.0421	1.000	1.000
75	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(8), ACTN2(21), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), CXCL12(8), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(7), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), ITK(25), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(17), MMP2(9), MMP9(8), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NCF1(3), NCF2(8), NCF4(8), NOX1(13), NOX3(7), OCLN(6), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAC2(2), RAP1A(1), RAP1B(1), RAPGEF3(14), RAPGEF4(19), RASSF5(4), RHOA(3), RHOH(5), ROCK1(6), ROCK2(14), SIPA1(9), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCAM1(17), VCL(9)	52458635	909	214	866	480	594	71	30	103	106	5	0.0175	1.000	1.000
76	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(34), ADCY8(54), ARAF(5), ATF4(9), CACNA1C(60), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(19), GNAQ(6), GRIA1(52), GRIA2(43), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF3(14), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21)	41118623	1015	214	935	582	681	85	40	99	104	6	0.0753	1.000	1.000
77	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C1(3), AKR1C2(5), AKR1C3(12), AKR1C4(10), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2F1(13), CYP2S1(14), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(2), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19)	24369215	878	212	787	381	630	53	37	54	101	3	1.43e-09	1.000	1.000
78	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(18), ABCA10(24), ABCA12(80), ABCA13(80), ABCA2(14), ABCA3(16), ABCA4(58), ABCA5(12), ABCA6(30), ABCA7(18), ABCA8(38), ABCA9(22), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(53), ABCB6(2), ABCB7(6), ABCB8(4), ABCB9(7), ABCC1(15), ABCC10(15), ABCC11(19), ABCC12(26), ABCC2(12), ABCC3(32), ABCC4(14), ABCC5(12), ABCC6(31), ABCC8(44), ABCC9(62), ABCD1(1), ABCD2(22), ABCD3(12), ABCD4(3), ABCG1(12), ABCG2(5), ABCG4(7), ABCG5(6), ABCG8(13), CFTR(62), TAP1(2), TAP2(14)	50128219	1039	212	976	586	685	84	35	109	120	6	0.00316	1.000	1.000
79	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPP5D(39), INPPL1(16), ITPK1(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), OCRL(7), PI4KA(22), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PRKCA(9), PRKCG(17), SYNJ1(23), SYNJ2(22)	52369739	972	210	900	455	680	52	39	82	113	6	1.18e-05	1.000	1.000
80	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ASIP(1), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CREB3(1), CREB3L1(7), CREB3L2(11), CREB3L3(13), CREB3L4(7), CREBBP(24), CTNNB1(17), DCT(4), DVL1(1), DVL2(3), DVL3(9), EDN1(9), EDNRB(7), EP300(19), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GSK3B(3), HRAS(6), KIT(13), KITLG(10), KRAS(7), LEF1(4), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MC1R(1), MITF(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), POMC(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), TCF7(1), TCF7L1(4), TCF7L2(8), TYR(11), TYRP1(9), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6)	45900891	869	210	807	455	545	83	47	93	97	4	0.00280	1.000	1.000
81	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ATF4(9), CACNA1C(60), CACNA1D(36), CACNA1F(24), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDC42(2), CGA(1), EGFR(26), ELK1(3), FSHB(9), GNA11(9), GNAQ(6), GNAS(33), GNRH2(2), GNRHR(3), GRB2(2), HBEGF(1), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), KRAS(7), LHB(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK9(4), MMP14(3), MMP2(9), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLD1(15), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCD(5), PRKX(3), PTK2B(12), RAF1(12), SOS1(10), SOS2(13), SRC(2)	53527497	1037	209	972	631	672	95	46	101	118	5	0.225	1.000	1.000
82	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(6), ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(8), CDC42(2), CDH1(6), CREBBP(24), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), EGFR(26), EP300(19), ERBB2(10), FARP2(7), FER(3), FGFR1(12), FYN(8), IGF1R(15), INSR(23), IQGAP1(10), LEF1(4), LMO7(30), MAP3K7(1), MAPK1(4), MAPK3(3), MET(23), MLLT4(17), NLK(5), PARD3(20), PTPN1(4), PTPN6(5), PTPRB(97), PTPRF(35), PTPRJ(9), PTPRM(8), PVRL1(4), PVRL2(8), PVRL3(5), PVRL4(10), RAC2(2), RHOA(3), SMAD2(5), SMAD3(4), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(16), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(8), TGFBR2(9), TJP1(16), VCL(9), WAS(8), WASF1(5), WASF2(6), WASF3(14), WASL(4), YES1(4)	50962794	768	203	730	386	496	67	33	80	87	5	0.225	1.000	1.000
83	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADK(5), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(11), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), FHIT(2), GART(10), GDA(16), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NPR1(17), NPR2(21), NT5E(7), NT5M(2), NUDT2(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(44), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6B(16), PDE6C(25), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(13), PFAS(12), PKLR(14), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4)	54462095	941	202	885	486	640	77	34	92	96	2	0.00292	1.000	1.000
84	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(6), B3GNT1(3), B3GNT2(2), B3GNT6(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), CHPF(4), CHST1(11), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), FUT11(4), FUT8(8), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GANAB(6), GCNT1(6), GCNT3(8), GCNT4(3), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), NDST1(6), NDST2(2), NDST3(25), NDST4(51), OGT(9), RPN2(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GAL1(8), ST6GALNAC1(8), STT3B(5), WBSCR17(46), XYLT1(12), XYLT2(5)	46699723	760	201	730	404	487	66	35	79	93	0	0.0488	1.000	1.000
85	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(15), ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), ATM(16), ATR(22), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDC14A(6), CDC14B(3), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(14), CDC6(2), CDC7(3), CDK2(1), CDK4(8), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(3), DBF4(6), E2F1(6), E2F2(5), E2F3(4), EP300(19), ESPL1(19), FZR1(8), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(22), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), RBL2(6), SFN(2), SKP2(3), SMAD2(5), SMAD3(4), SMAD4(2), SMC1A(3), SMC1B(25), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	57462260	546	200	533	247	309	49	37	92	57	2	0.184	1.000	1.000
86	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(5), CASP3(3), CD244(10), CD247(4), CD48(8), CSF2(2), FAS(5), FASLG(15), FCER1G(1), FCGR3A(9), FCGR3B(8), FYN(8), GRB2(2), GZMB(4), HLA-A(4), HLA-B(6), HLA-C(2), HLA-E(1), HLA-G(5), HRAS(6), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), ITGAL(27), ITGB2(17), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KLRC1(4), KLRC2(7), KLRC3(8), KLRD1(7), KLRK1(7), KRAS(7), LAT(3), LCK(17), LCP2(8), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MICA(4), MICB(7), NCR1(18), NCR3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK1(4), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRF1(14), PRKCA(9), PRKCG(17), PTK2B(12), PTPN11(10), PTPN6(5), RAC2(2), RAF1(12), SH2D1A(3), SH2D1B(5), SH3BP2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SYK(15), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFSF10(10), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(6), VAV1(19), VAV2(5), VAV3(11), ZAP70(8)	46874525	900	200	856	451	582	71	33	99	111	4	0.0350	1.000	1.000
87	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), AKAP1(12), AKAP10(3), AKAP11(12), AKAP12(6), AKAP3(17), AKAP4(19), AKAP6(41), AKAP7(3), AKAP8(7), AKAP9(38), ARHGEF1(2), CALM1(1), CALM2(1), CHMP1B(1), GNA11(9), GNA12(3), GNA13(1), GNA14(7), GNA15(7), GNAI2(6), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(3), GNG10(1), GNG4(3), GNG7(2), GNGT2(5), HRAS(6), ITPR1(36), KCNJ3(21), KRAS(7), PALM2(3), PDE1A(44), PDE1B(15), PDE1C(54), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(5), USP5(8)	49567071	831	199	791	493	570	64	36	78	83	0	0.469	1.000	1.000
88	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(15), ACTN1(8), ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGEF6(11), ARHGEF7(5), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(36), FYN(8), GRB2(2), GRB7(9), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGB3BP(3), MAP2K4(4), MAP2K7(7), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(48), MYLK2(13), P4HB(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PKLR(14), PLCG1(9), PLCG2(30), PTK2(7), RAF1(12), RALA(1), RHO(2), ROCK1(6), ROCK2(14), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(2), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8)	50580065	813	199	773	416	521	68	29	109	84	2	0.118	1.000	1.000
89	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(41), CBL(10), CBLB(21), CBLC(16), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD40LG(1), CD8A(2), CD8B(9), CDC42(2), CDK4(8), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(8), GRAP2(7), GRB2(2), HRAS(6), ICOS(3), IFNG(4), IKBKB(4), IL10(2), IL2(4), IL4(1), IL5(4), ITK(25), JUN(1), KRAS(7), LAT(3), LCK(17), LCP2(8), MALT1(8), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCQ(21), PTPN6(5), PTPRC(36), RASGRP1(11), RHOA(3), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(5), VAV3(11), ZAP70(8)	43011853	730	198	694	349	457	60	28	91	89	5	0.0876	1.000	1.000
90	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(15), ABL2(12), AKT1(4), AKT2(8), AKT3(3), ARAF(5), AREG(8), BAD(4), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CBL(10), CBLB(21), CBLC(16), CDKN1A(3), CDKN1B(2), CRK(3), CRKL(2), EGF(22), EGFR(26), EIF4EBP1(1), ELK1(3), ERBB2(10), ERBB3(7), ERBB4(59), EREG(4), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(6), JUN(1), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MYC(5), NCK1(2), NCK2(5), NRG1(23), NRG2(9), NRG3(24), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), RAF1(12), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(5), TGFA(2)	42912773	758	197	713	366	476	64	34	92	90	2	0.0908	1.000	1.000
91	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(6), CD40(4), CD80(4), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IKBKB(4), IKBKE(9), IL12A(4), IL12B(3), IL1B(8), IL6(2), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(10), LY96(4), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(3), TICAM1(8), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(42), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(18), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	37684887	571	197	545	289	368	40	29	72	60	2	0.0401	1.000	1.000
92	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(20), AMY2A(7), AMY2B(14), ENPP1(13), ENPP3(15), G6PC(6), GAA(8), GANAB(6), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), MGAM(190), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), SI(94), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UXS1(6)	24148111	691	196	624	297	485	63	28	48	65	2	5.04e-05	1.000	1.000
93	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(5), ACVR2B(3), ACVRL1(12), AMHR2(15), BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BMPR1A(2), BMPR1B(4), BMPR2(7), CHRD(21), COMP(8), CREBBP(24), CUL1(3), DCN(19), E2F4(3), E2F5(3), EP300(19), FST(6), GDF5(16), GDF6(2), GDF7(1), ID1(1), ID2(2), IFNG(4), INHBA(20), INHBB(9), INHBC(13), INHBE(5), LEFTY1(9), LEFTY2(4), LTBP1(46), MAPK1(4), MAPK3(3), MYC(5), NODAL(2), NOG(2), PITX2(6), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), RBL1(14), RBL2(6), RHOA(3), ROCK1(6), ROCK2(14), RPS6KB1(4), RPS6KB2(2), SMAD1(5), SMAD2(5), SMAD3(4), SMAD4(2), SMAD5(2), SMAD6(7), SMAD7(1), SMAD9(12), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNF(1), ZFYVE16(7), ZFYVE9(8)	42268096	637	192	607	287	402	60	30	63	82	0	0.0335	1.000	1.000
94	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), F10(10), F11(14), F12(1), F2(13), F2R(8), F5(39), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), PROC(11), PROS1(17), SERPINC1(7), SERPING1(14)	18897075	671	190	622	183	500	40	19	54	53	5	0.000597	1.000	1.000
95	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(3), ACVRL1(12), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(7), BUB1(6), CDKL1(1), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MAP3K10(13), MOS(6), NEK1(7), NEK3(2), OCRL(7), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PIM2(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKG1(15), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(4), STK11(4), VRK1(1)	47819286	782	190	727	415	532	48	27	77	94	4	0.262	1.000	1.000
96	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(10), AGTR2(10), ATP8A1(33), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CX3CR1(17), CXCR3(4), CXCR4(3), CXCR6(6), EDNRA(12), EDNRB(7), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(3), GRPR(7), LHCGR(29), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), NMBR(8), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), TACR1(8), TACR2(9), TACR3(29), TRHR(24), TSHR(8)	22324664	620	189	582	417	429	53	26	60	52	0	0.000306	1.000	1.000
97	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(1), ACMSD(13), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CAT(8), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADHA(6), KMO(8), KYNU(16), MAOA(4), MAOB(13), SDS(3), TDO2(4), TPH1(12), WARS(5), WARS2(4)	23386276	609	188	573	341	438	39	20	44	65	3	0.0342	1.000	1.000
98	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(9), BAD(4), BCL2(3), CABIN1(17), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(13), CREBBP(24), CSF2(2), CSNK2A1(2), CSNK2B(1), CTLA4(2), EGR2(5), EGR3(4), EP300(19), FCER1A(17), FCGR3A(9), FOS(2), GATA3(9), GATA4(5), GSK3A(1), GSK3B(3), HRAS(6), ICOS(3), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL13(2), IL1B(8), IL2(4), IL2RA(7), IL3(3), IL4(1), IL6(2), ITK(25), KPNA5(2), MAP2K7(7), MAPK14(5), MAPK8(3), MAPK9(4), MEF2A(3), MEF2B(3), MEF2D(6), MYF5(16), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB2(5), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PTPRC(36), RELA(4), RPL13A(2), SFN(2), SLA(4), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(5), VAV3(11), XPO5(8)	38810128	562	184	540	312	370	40	24	49	74	5	0.572	1.000	1.000
99	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(10), AKR1D1(21), ARSD(3), ARSE(5), CARM1(7), CYP11B1(19), CYP11B2(12), CYP19A1(16), HEMK1(4), HSD11B1(14), HSD11B2(2), HSD17B12(4), HSD17B2(13), HSD17B3(5), HSD17B7(1), HSD3B1(15), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(6), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), WBSCR22(2)	21258474	613	183	550	249	423	55	21	41	71	2	7.21e-08	1.000	1.000
100	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AKR1A1(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(4), DGAT1(1), DGAT2(7), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), GPAM(6), LCT(54), LIPA(5), LIPC(10), LIPF(17), LIPG(10), LPL(6), MGLL(11), PNLIP(9), PNLIPRP1(10), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10)	24538582	523	181	479	223	350	48	21	51	51	2	1.62e-05	1.000	1.000
101	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(9), ADCY8(54), CACNA1A(38), CACNA1B(40), GNAS(33), GNAT3(5), GNB1(1), GNB3(7), GRM4(22), ITPR3(12), KCNB1(37), PDE1A(44), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), SCNN1A(12), SCNN1B(16), SCNN1G(33), TAS1R1(14), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(5), TAS2R16(10), TAS2R3(2), TAS2R38(19), TAS2R39(14), TAS2R4(4), TAS2R40(6), TAS2R41(13), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(20), TAS2R7(5), TAS2R8(5), TAS2R9(10), TRPM5(14)	24119177	598	180	559	466	402	43	28	60	62	3	0.758	1.000	1.000
102	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPPL1(16), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(11), MINPP1(1), MIOX(7), OCRL(7), PI4KA(22), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), SYNJ1(23), SYNJ2(22)	31106789	577	179	543	265	396	31	28	53	66	3	0.000393	1.000	1.000
103	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(15), CARD11(41), CD19(8), CD22(26), CD72(5), CD79A(4), CD81(3), CHUK(2), CR2(36), FCGR2B(3), FOS(2), GSK3B(3), HRAS(6), IKBKB(4), INPP5D(39), JUN(1), KRAS(7), LILRB3(4), LYN(11), MALT1(8), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTPN6(5), RAC2(2), RASGRP3(12), SYK(15), VAV1(19), VAV2(5), VAV3(11)	31376463	545	179	525	249	345	37	27	60	69	7	0.00870	1.000	1.000
104	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(4), AKT2(8), AKT3(3), BTK(15), CSF2(2), FCER1A(17), FCER1G(1), FYN(8), GAB2(4), GRB2(2), HRAS(6), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(39), KRAS(7), LAT(3), LCP2(8), LYN(11), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MS4A2(13), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PRKCA(9), PRKCD(5), PRKCE(7), RAC2(2), RAF1(12), SOS1(10), SOS2(13), SYK(15), TNF(1), VAV1(19), VAV2(5), VAV3(11)	30376442	549	178	520	243	344	42	18	65	76	4	0.00174	1.000	1.000
105	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(15), ALG6(2), CCKBR(14), CCR2(17), CCR3(11), CCR5(10), CELSR1(31), CELSR2(26), CELSR3(32), CHRM2(26), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(12), EMR2(6), EMR3(22), F2R(8), FSHR(21), GHRHR(12), GNRHR(3), GPR116(38), GPR132(3), GPR133(16), GPR143(4), GPR17(1), GPR18(5), GPR55(6), GPR61(7), GPR84(9), GRM1(13), GRPR(7), HRH4(6), LGR6(22), LPHN2(50), LPHN3(24), LTB4R2(1), NTSR1(8), OR2M4(14), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1)	28348932	588	177	556	375	387	50	25	62	61	3	0.0585	1.000	1.000
106	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(6), ACADL(5), ACADM(5), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ANGPTL4(5), APOA1(1), APOA2(1), APOA5(5), APOC3(2), AQP7(5), CD36(6), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP27A1(4), CYP4A11(32), CYP4A22(27), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(7), FABP3(1), FABP4(2), FABP7(1), FADS2(4), GK(7), HMGCS2(18), ILK(2), LPL(6), ME1(22), MMP1(14), NR1H3(5), OLR1(6), PCK1(28), PCK2(6), PDPK1(5), PLTP(1), PPARA(8), PPARD(3), PPARG(12), RXRA(4), RXRB(4), RXRG(6), SCD(4), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(6), SLC27A5(10), SLC27A6(34), SORBS1(16), UBC(6), UCP1(5)	27471534	552	177	514	289	376	53	21	38	61	3	0.0456	1.000	1.000
107	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(15), ATM(16), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(3), CDH1(6), CDK2(1), CDK4(8), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), EP300(19), ESPL1(19), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), HDAC8(5), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MPEG1(6), MPL(9), PCNA(2), PLK1(4), PRKDC(22), PTPRA(9), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), SKP2(3), SMAD4(2), TBC1D8(11), TFDP1(2), TGFB1(2), WEE1(2)	46113359	436	176	425	216	258	42	22	69	43	2	0.333	1.000	1.000
108	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(14), EGFR(26), ERBB2(10), ERBB4(59), ETS1(4), ETS2(8), ETV6(10), ETV7(7), FMN2(87), GRB2(2), KRAS(7), MAP2K1(18), MAPK1(4), MAPK3(3), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), PIWIL1(23), PIWIL2(13), PIWIL3(16), PIWIL4(4), RAF1(12), SOS1(10), SOS2(13), SPIRE1(3), SPIRE2(7)	21721514	485	174	459	216	336	33	14	56	45	1	0.100	1.000	1.000
109	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(6), AGT(8), AGTR1(10), AGTR2(10), CMA1(6), COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), REN(12)	10723906	437	172	404	109	339	20	8	25	40	5	0.0512	1.000	1.000
110	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(6), CHUK(2), DAXX(10), ELK1(3), FOS(2), GRB2(2), HRAS(6), IKBKB(4), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(27), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAP4K5(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK4(17), MAPK6(8), MAPK7(4), MAPK8(3), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MKNK2(4), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(9), RAF1(12), RELA(4), RIPK1(3), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2)	39425216	479	172	459	239	285	50	23	65	55	1	0.389	1.000	1.000
111	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(12), CAMK4(17), CREBBP(24), CSNK1A1(5), EDN1(9), ELSPBP1(8), F2(13), FGF2(2), GATA4(5), GSK3B(3), HAND1(2), HAND2(5), HRAS(6), IGF1(11), LIF(3), MAP2K1(18), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MEF2C(5), MYH2(100), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKX2-5(1), NPPA(5), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(12), RPS6KB1(4), SYT1(23)	21667767	444	172	407	240	294	43	16	41	45	5	0.421	1.000	1.000
112	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(5), ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), G6PC2(3), GALM(2), GAPDH(3), GAPDHS(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGAM4(1), PGK1(3), PGK2(36), PGM1(8), PGM3(1), PKLR(14), TPI1(1)	24794019	414	170	379	200	279	29	25	40	41	0	0.00182	1.000	1.000
113	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN1(5), CAPN2(6), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CSF2RB(25), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL3(3), IL3RA(8), IRAK1(5), IRAK2(15), IRAK3(11), IRAK4(3), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(10), TRAF2(2)	35079562	453	170	439	261	281	34	21	58	58	1	0.858	1.000	1.000
114	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(4), AKT2(8), AKT3(3), BAD(4), CASP9(2), CDC42(2), HRAS(6), KDR(57), KRAS(7), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NOS3(20), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCA(9), PRKCG(17), PTGS2(13), PTK2(7), PXN(2), RAC2(2), RAF1(12), SH2D2A(5), SHC2(7), SPHK1(2), SPHK2(8), SRC(2), VEGFA(5)	30374064	538	170	510	247	349	38	15	68	65	3	0.00697	1.000	1.000
115	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(16), EGFR(26), EPHB2(36), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(10), PITX2(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), RAF1(12), RGS20(3), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(11), TERF2IP(2)	24252675	469	169	434	260	314	40	20	44	47	4	0.167	1.000	1.000
116	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(23), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(10), CD36(6), CHUK(2), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), G6PC(6), G6PC2(3), IKBKB(4), IRS1(5), IRS2(3), IRS4(11), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), MAPK10(9), MAPK8(3), MAPK9(4), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(28), PCK2(6), POMC(4), PPARA(8), PPARGC1A(26), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKCQ(21), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(8), SOCS3(1), STAT3(11), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(9)	35378840	533	168	513	305	340	49	23	52	69	0	0.581	1.000	1.000
117	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(7), CLK2(8), CLK3(2), COL2A1(44), CPSF1(8), CPSF2(2), CPSF3(3), CSTF1(6), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(4), DDX20(11), DHX15(5), DHX16(9), DHX38(10), DHX8(11), DHX9(11), DICER1(23), DNAJC8(2), FUS(1), GIPC1(6), LSM7(2), METTL3(3), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(2), PAPOLA(4), PHF5A(2), POLR2A(14), PPM1G(2), PRPF18(4), PRPF3(6), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(5), PTBP2(8), RBM17(1), RBM5(10), RNGTT(3), RNMT(9), RNPS1(2), SF3A1(6), SF3A2(6), SF3A3(7), SF3B1(17), SF3B2(11), SF3B4(9), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(2), SNRPF(1), SNRPN(7), SNURF(3), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(9), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6)	45295081	437	168	430	181	252	34	29	59	62	1	0.262	1.000	1.000
118	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AKR1A1(4), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), LCT(54), LIPC(10), LIPF(17), LIPG(10), LPL(6), PNLIP(9), PNLIPRP1(10), PPAP2A(1), PPAP2B(11), PPAP2C(10)	20528996	450	167	410	201	313	39	17	40	39	2	0.000233	1.000	1.000
119	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(12), ALOX12(6), ALOX12B(16), ALOX15(11), ALOX15B(9), ALOX5(14), CBR3(1), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP2U1(2), CYP4A11(32), CYP4A22(27), CYP4F2(17), CYP4F3(26), EPHX2(6), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), LTA4H(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16)	16489245	573	165	533	329	420	40	10	35	65	3	0.00627	1.000	1.000
120	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), P4HB(3), SLC23A1(6), SLC23A2(4), SLC2A1(5), SLC2A3(7)	10605285	410	164	379	87	318	18	10	24	36	4	0.000227	1.000	1.000
121	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), PON1(15)	12424580	438	163	408	255	329	24	11	20	52	2	0.00670	1.000	1.000
122	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(4), BDKRB2(10), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(8), FLT1(42), FLT4(31), KDR(57), NOS3(20), PDE2A(17), PDE3A(30), PDE3B(6), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(15), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23)	17323211	423	163	399	237	285	36	10	42	48	2	0.211	1.000	1.000
123	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(4), AKT2(8), AKT3(3), BAD(4), CDC42(2), CDK2(1), CDKN1B(2), CREB3(1), CREB5(9), ERBB4(59), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), MET(23), MYC(5), NOLC1(7), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(10), PTK2(7), PTPN1(4), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SLC2A4(8), SOS1(10), SOS2(13), TSC1(9), TSC2(14), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	32347743	453	163	434	249	276	44	23	58	51	1	0.720	1.000	1.000
124	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(16), CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG2(1), CCNH(2), CDC25A(8), CDK2(1), CDK4(8), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CREB3(1), CREB3L1(7), CREB3L3(13), CREB3L4(7), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MNAT1(2), MYC(5), MYT1(21), NACA(44), PCNA(2), POLA2(9), POLE(16), POLE2(2), PRIM1(3), RB1(10), RBL1(14), RPA1(3), RPA2(2), TFDP1(2), TFDP2(3), TNXB(126), WEE1(2)	32924192	442	162	429	199	290	38	18	57	37	2	0.0284	1.000	1.000
125	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(2), ALAS2(6), BLVRA(2), BLVRB(1), COX10(8), COX15(4), CP(14), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UROS(1)	17947818	454	161	405	168	318	34	18	27	55	2	2.18e-06	1.000	1.000
126	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BTRC(4), CSNK1A1(5), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(44), GLI3(19), GSK3B(3), HHIP(27), IHH(4), LRP2(108), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), PTCH1(6), PTCH2(18), RAB23(1), SHH(3), SMO(10), STK36(17), SUFU(3), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6), ZIC2(3)	25738464	520	161	484	260	355	47	20	50	48	0	0.0277	1.000	1.000
127	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), BCR(14), BLNK(15), BTK(15), CD19(8), CD22(26), CD81(3), CR2(36), CSK(1), DAG1(9), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(39), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), MAP4K1(12), MAPK1(4), MAPK3(3), NFATC1(18), NFATC2(12), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(36), RAF1(12), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19)	31460302	511	160	487	255	326	39	27	52	62	5	0.0449	1.000	1.000
128	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(7), ACTG2(6), ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), CDC42(2), CFL1(2), FLNA(23), FLNC(69), FSCN1(4), FSCN2(2), FSCN3(13), GDI1(2), GDI2(3), LIMK1(5), MYH2(100), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(6), ROCK2(14), VASP(3), WASF1(5), WASL(4)	20341404	438	160	402	236	303	46	12	39	36	2	0.0237	1.000	1.000
129	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP4A11(32), CYP4A22(27), ECHS1(3), EHHADH(6), GCDH(7), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6)	20936387	404	159	370	166	288	27	23	24	41	1	0.000107	1.000	1.000
130	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), RRM1(3), RRM2(4), RRM2B(2), TK1(1), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UPB1(14), UPP1(1), UPP2(6), UPRT(1)	34487643	444	159	417	225	286	36	15	64	42	1	0.163	1.000	1.000
131	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(37), ASH2L(5), CARM1(7), CTCFL(21), DOT1L(12), EED(3), EHMT1(11), EHMT2(11), EZH1(10), EZH2(13), FBXO11(7), HCFC1(21), HSF4(1), JMJD4(7), JMJD6(2), KDM6A(3), MEN1(3), MLL3(2), NSD1(21), OGT(9), PAXIP1(3), PPP1CA(3), PPP1CB(5), PPP1CC(2), PRDM2(15), PRDM7(5), PRDM9(51), PRMT1(3), PRMT5(7), PRMT7(4), PRMT8(10), RBBP5(4), SATB1(22), SETD1A(27), SETD2(16), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(8), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(3), WHSC1(10), WHSC1L1(6)	50390913	447	158	433	197	283	51	13	62	38	0	0.387	1.000	1.000
132	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3)	22350623	380	158	361	169	235	37	15	49	43	1	0.00369	1.000	1.000
133	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3)	22350623	380	158	361	169	235	37	15	49	43	1	0.00369	1.000	1.000
134	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGAP1(3), ARHGAP4(4), ARHGEF11(23), BTK(15), CDC42(2), CFL1(2), GDI1(2), GDI2(3), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(12), LIMK1(5), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PITX2(6), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(6), ROCK2(14), SAG(11), WASF1(5), WASL(4)	29440830	433	157	409	213	286	35	17	55	39	1	0.0305	1.000	1.000
135	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), CARM1(7), COMT(4), DBH(16), DCT(4), DDC(16), ECH1(5), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(15), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NAT6(5), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SH3GLB1(2), TAT(21), TH(11), TPO(49), TYR(11), TYRP1(9), WBSCR22(2)	25297475	443	156	416	241	306	37	22	36	42	0	0.258	1.000	1.000
136	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(5), AKT1(4), APC(27), CAMP(2), CAV3(2), DAG1(9), DLG4(7), EPHB2(36), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(6), PTX3(1), RHO(2), RYR1(114)	19228527	335	156	323	212	223	30	16	26	38	2	0.434	1.000	1.000
137	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1)	20812840	354	155	323	161	240	28	20	35	31	0	0.000464	1.000	1.000
138	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1)	20812840	354	155	323	161	240	28	20	35	31	0	0.000464	1.000	1.000
139	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(3), CREBBP(24), CTBP2(6), DLL1(3), DLL3(7), DLL4(12), DTX1(7), DTX2(2), DTX3(5), DTX3L(6), DTX4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), HDAC1(2), HDAC2(2), HES1(2), JAG1(10), JAG2(10), LFNG(5), MAML1(9), MAML2(7), MAML3(9), MFNG(8), NCOR2(28), NCSTN(5), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), NUMB(4), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(3)	29318409	364	155	360	211	222	41	13	50	38	0	0.908	1.000	1.000
140	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), XYLB(6)	11594001	380	154	332	146	274	27	14	19	45	1	5.30e-05	1.000	1.000
141	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(36), FBXW7(11), GRAP2(7), GRB2(2), ITK(25), ITPKB(11), LAT(3), LCK(17), LCP2(8), MAPK1(4), NCK1(2), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(9), PTPRC(36), RAF1(12), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), SOS1(10), SOS2(13), VAV1(19), ZAP70(8)	23625534	427	154	407	213	271	33	17	48	55	3	0.215	1.000	1.000
142	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(10), F11(14), F12(1), F13B(35), F2(13), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), LPA(59), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6), SERPINF2(7), VWF(60)	14972071	441	153	419	176	311	27	23	38	40	2	0.00519	1.000	1.000
143	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(7), ATM(16), ATR(22), BAI1(16), BAX(5), CASP3(3), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG1(2), CCNG2(1), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(11), IGFBP3(3), MDM2(4), MDM4(2), PERP(3), PPM1D(4), RFWD2(7), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(10), SERPINE1(6), SESN1(2), SESN2(7), SESN3(1), SFN(2), STEAP3(9), THBS1(31), TNFRSF10B(5), TP53I3(3), TP73(6), TSC2(14), ZMAT3(1)	26708545	317	152	306	171	200	26	17	40	33	1	0.627	1.000	1.000
144	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(4), AKT2(8), AKT3(3), BCR(14), BTK(15), CD19(8), DAPP1(6), FLOT1(2), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(6), PLCG2(30), PPP1R13B(9), PREX1(10), PTPRC(36), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SAG(11), SYK(15), TEC(13), VAV1(19)	22834294	338	152	317	194	217	24	18	37	40	2	0.318	1.000	1.000
145	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(5), CALR(2), CANX(1), CD4(9), CD74(8), CD8A(2), CD8B(9), CIITA(18), CTSS(7), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), HSP90AA1(3), HSP90AB1(8), HSPA5(7), IFI30(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KIR3DL3(5), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LGMN(5), LTA(5), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(14), TAPBP(2)	19638215	363	151	346	217	242	32	14	39	35	1	0.466	1.000	1.000
146	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MIOX(7), OCRL(7), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30)	18985076	398	151	360	174	278	20	17	34	46	3	0.00141	1.000	1.000
147	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(4), AKT2(8), AKT3(3), BAD(4), BCR(14), BLNK(15), BTK(15), CD19(8), CSK(1), DAG1(9), EPHB2(36), GRB2(2), ITPKB(11), LYN(11), MAP2K1(18), MAP2K2(5), MAPK1(4), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), RAF1(12), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19)	22505137	356	150	335	199	219	28	15	47	44	3	0.644	1.000	1.000
148	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ACAT2(1), ACMSD(13), AFMID(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CARM1(7), CAT(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADH(3), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(10), KMO(8), KYNU(16), LCMT1(4), LCMT2(1), LNX1(20), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NFX1(10), OGDH(10), OGDHL(44), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(2)	25767980	436	149	414	215	290	36	19	47	42	2	0.0345	1.000	1.000
149	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(10), ADAM17(1), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), CASP3(3), CDC42(2), CHUK(2), CSK(1), EGFR(26), F11R(7), GIT1(6), HBEGF(1), IGSF5(12), IKBKB(4), JAM2(11), JAM3(3), JUN(1), LYN(11), MAP2K4(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(3), MAPK9(4), MET(23), NFKB1(6), NFKB2(5), NFKBIA(2), NOD1(10), PAK1(4), PLCG1(9), PLCG2(30), PTPN11(10), PTPRZ1(27), RELA(4), SRC(2), TCIRG1(6), TJP1(16)	29808581	379	149	372	220	226	31	19	52	50	1	0.803	1.000	1.000
150	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(5), BAK1(2), BAX(5), BFAR(2), BTK(15), CAD(18), CASP10(10), CASP3(3), CASP8(9), CD7(2), CDK2AP1(2), CSNK1A1(5), DAXX(10), DEDD(2), DEDD2(3), DFFA(2), DIABLO(3), EGFR(26), EPHB2(36), FAF1(9), FAIM2(6), HSPB1(2), IL1A(5), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MET(23), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(17), RALBP1(3), RIPK1(3), ROCK1(6), SMPD1(3), TNFRSF6B(2), TPX2(11), TRAF2(2), TUFM(8)	30548804	376	149	364	219	227	27	19	48	54	1	0.907	1.000	1.000
151	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH4A1(6), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), GAMT(5), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(77), NOS3(20), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), P4HB(3), PYCR1(1), RARS(7), SMS(5)	18768312	349	148	330	182	223	36	17	30	42	1	0.0721	1.000	1.000
152	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), ELK1(3), FPR1(22), GNA15(7), GNB1(1), HRAS(6), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NCF1(3), NCF2(8), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(56), PLCB1(61), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), RELA(4), SYT1(23)	16042826	358	148	320	145	243	27	12	33	42	1	0.00306	1.000	1.000
153	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(10), B4GALT1(2), B4GALT2(3), G6PC(6), G6PC2(3), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), HSD3B7(5), LALBA(8), LCT(54), MGAM(190), PFKL(3), PFKM(2), PFKP(2), PGM1(8), PGM3(1), RDH11(3), RDH12(2), RDH13(3), RDH14(1), UGP2(1)	16418433	390	148	363	221	290	31	9	34	25	1	0.0791	1.000	1.000
154	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(7), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), NOS1(77), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), SYT1(23)	10852964	354	147	331	218	258	29	9	23	33	2	0.225	1.000	1.000
155	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(3), FBP2(2), G6PC(6), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), LALBA(8), LCT(54), MGAM(190), PFKM(2), PFKP(2), PGM1(8), PGM3(1)	13840899	361	146	334	201	269	31	8	30	22	1	0.0655	1.000	1.000
156	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(6), GPD1(10), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), NAT6(5), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10), PTDSS2(3), SH3GLB1(2)	27808795	388	146	366	199	247	32	17	40	49	3	0.171	1.000	1.000
157	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(27), AXIN1(10), CCND1(2), CCND2(7), CCND3(2), CSNK1E(5), CTNNB1(17), DVL1(1), DVL2(3), DVL3(9), FBXW2(2), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LDLR(19), MAPK10(9), MAPK9(4), MYC(5), PAFAH1B1(6), PLAU(3), PPP2R5C(4), PPP2R5E(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), RHOA(3), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6)	25283138	358	146	348	191	223	34	10	38	53	0	0.215	1.000	1.000
158	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ITPA(1), NME1(1), NT5E(7), NT5M(2), NUDT2(2), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), RRM1(3), RRM2(4), TK1(1), TK2(1), TXNRD1(5), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(14), UPP1(1)	24451868	338	145	313	151	214	31	11	51	30	1	0.0137	1.000	1.000
159	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(55), C5(23), C6(72), C7(49), ICAM1(2), IL1A(5), IL6(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELP(38), SELPLG(11), TNF(1), VCAM1(17)	10497617	371	144	336	153	262	12	18	36	38	5	0.000448	1.000	1.000
160	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), COMT(4), DBH(16), DCT(4), DDC(16), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(15), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(21), TH(11), TPO(49), TYR(11)	13462769	357	144	332	197	258	29	15	22	33	0	0.0646	1.000	1.000
161	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPS(5), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CLC(5), CPT1B(9), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), ETNK1(5), GNPAT(1), GPD1(10), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB2(12), PLCG1(9), PLCG2(30), PPAP2A(1), PPAP2B(11), PPAP2C(10)	21257308	365	143	349	181	238	28	12	37	46	4	0.0138	1.000	1.000
162	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(10), AKR1D1(21), ARSB(3), ARSD(3), ARSE(5), CYP11B1(19), CYP11B2(12), HSD11B1(14), HSD11B2(2), HSD17B2(13), HSD17B3(5), HSD3B1(15), HSD3B2(14), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35)	11606136	346	142	311	151	233	36	15	22	38	2	0.000187	1.000	1.000
163	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(56), B3GALT4(2), CDR1(13), DGKI(36), IL6ST(11), MRPL19(1), PIGK(7), RPL10(4), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL22(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(5), RPL5(8), RPL6(1), RPL7(2), RPLP0(1), RPLP2(1), RPS11(1), RPS13(1), RPS15(1), RPS16(2), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(12), TBC1D10C(6), TSPAN9(4), UBB(1), UBC(6)	22127343	290	142	275	165	183	27	15	31	34	0	0.579	1.000	1.000
164	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(15), CALM1(1), CALM2(1), ELK1(3), FCER1A(17), FCER1G(1), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK2(9), PIK3CA(10), PIK3R1(4), PLA2G4A(16), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19)	18306564	302	141	282	136	186	21	13	41	38	3	0.285	1.000	1.000
165	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(10), ALOX15(11), ALOX5(14), CYP1A2(9), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), HSD3B7(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), RDH11(3), RDH12(2), RDH13(3), RDH14(1)	10175182	371	141	347	207	271	19	11	19	48	3	0.0279	1.000	1.000
166	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(12), ACADL(5), ACADM(5), ACADSB(6), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), MLYCD(2), SDS(3), SMS(5), UPB1(14)	12394672	282	140	256	115	183	23	10	36	30	0	0.00188	1.000	1.000
167	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(16), BMPR1B(4), CCND2(7), CDK4(8), CDKN1B(2), DAZL(5), DMC1(11), EGR1(4), ESR2(10), FSHR(21), GJA4(4), INHA(4), LHCGR(29), MLH1(7), NCOR1(23), NR5A1(10), NRIP1(10), PGR(16), PRLR(38), PTGER2(7), SMPD1(3), VDR(3), ZP2(17)	14868394	259	139	232	136	164	19	9	33	33	1	0.655	1.000	1.000
168	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(9), DUSP4(4), DUSP8(3), GAB1(8), GCK(16), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(5), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK10(9), MAPK7(4), MAPK8(3), MAPK9(4), MYEF2(4), NFATC3(11), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4), ZAK(8)	21081080	320	139	307	166	214	26	8	36	34	2	0.791	1.000	1.000
169	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(27), AXIN1(10), AXIN2(5), CER1(18), CSNK1A1(5), CTNNB1(17), DACT1(13), DKK1(3), DKK2(19), DKK3(4), DKK4(4), DVL1(1), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(47), MVP(13), NKD1(9), NKD2(7), PIN1(1), PSEN1(3), PTPRA(9), SENP2(9), SFRP1(4), TSHB(7), WIF1(7)	17058518	267	138	256	137	158	31	11	30	35	2	0.385	1.000	1.000
170	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(8), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDK5(6), F2(13), FYN(8), GNA11(9), GNAI1(2), GNB1(1), GRB2(2), HRAS(6), JAK2(8), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MAPT(10), MYLK(48), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), SYT1(23)	17667566	291	137	268	166	180	22	13	38	36	2	0.615	1.000	1.000
171	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(8), APOA1(1), APOA2(1), CD36(6), CPT1B(9), CREBBP(24), DUSP1(1), DUT(1), EHHADH(6), EP300(19), FABP1(6), HSD17B4(6), HSPA1A(1), JUN(1), LPL(6), MAPK1(4), MAPK3(3), ME1(22), MRPL11(2), MYC(5), NCOA1(9), NCOR1(23), NCOR2(28), NFKBIA(2), NR0B2(6), NR1H3(5), NR2F1(8), NRIP1(10), PDGFA(1), PIK3CA(10), PIK3R1(4), PPARA(8), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(5), TNF(1)	27018423	327	137	317	165	207	31	22	34	29	4	0.465	1.000	1.000
172	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(4), APC(27), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(26), GNA11(9), GNA15(7), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(4), PITX2(6), PTX3(1), RAF1(12), SRC(2)	21993923	296	137	285	176	185	24	16	34	36	1	0.690	1.000	1.000
173	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(6), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(11), MAPK1(4), MAPK3(3), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PRKAA1(1), PRKAA2(32), RHEB(2), RICTOR(13), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), STK11(4), TSC1(9), TSC2(14), ULK1(11), ULK2(7), ULK3(1), VEGFA(5), VEGFB(3)	21478262	290	136	275	148	174	26	14	39	35	2	0.418	1.000	1.000
174	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GAPDHS(3), GCK(16), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6B(6), LDHB(2), LDHC(7), MDH1(3), MDH2(4), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGK1(3), PGK2(36), PKLR(14), TNFAIP1(2), TPI1(1)	18119057	284	135	267	156	200	21	15	23	25	0	0.0402	1.000	1.000
175	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(66), GABBR1(9), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM7(45), GRM8(50)	8913247	325	135	300	227	233	23	16	24	28	1	0.159	1.000	1.000
176	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(12), ACADM(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(5), SRM(1), UPB1(14)	11529012	257	135	233	110	164	22	11	32	28	0	0.00794	1.000	1.000
177	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(24), ACACB(23), ACAT2(1), ACOT12(15), ACSS1(2), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PCK2(6), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14)	19964758	291	135	278	153	191	19	19	31	30	1	0.210	1.000	1.000
178	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(10), AKR1C4(10), AKR1D1(21), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), HSD3B7(5), LIPA(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SLC27A5(10), SOAT1(3), SOAT2(6), SRD5A1(3)	13517370	287	134	255	123	188	30	22	21	25	1	0.000725	1.000	1.000
179	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(10), AADAC(16), ABAT(12), ACADS(6), ACAT2(1), ACSM1(32), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(8), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADH(3), HADHA(6), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(4), OXCT1(4), OXCT2(5), PDHA1(5), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(3), RDH12(2), RDH13(3), RDH14(1)	17313381	306	134	294	144	208	26	18	23	31	0	0.0246	1.000	1.000
180	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(4), CRK(3), CRKL(2), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(30), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K1(18), MAP2K2(5), MAP4K1(12), MAPK1(4), MAPK3(3), MAPK8(3), MET(23), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAF1(12), RAP1A(1), RAP1B(1), RASA1(5), SOS1(10), SRC(2), STAT3(11)	18275872	267	134	249	138	156	24	10	46	29	2	0.858	1.000	1.000
181	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(4), ATF1(5), CAMP(2), CREB3(1), CREB5(9), CREBBP(24), CRKL(2), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(27), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), NTRK1(16), OPN1LW(8), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN11(10), RPS6KA3(2), SHC1(2), SRC(2), TERF2IP(2), TH(11)	21156942	307	134	290	167	204	25	13	34	30	1	0.590	1.000	1.000
182	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(3), CCR3(11), CFL1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), LIMK1(5), MAP2K1(18), MAPK1(4), MAPK3(3), MYL2(9), NOX1(13), PIK3C2G(56), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2(7), RAF1(12), ROCK2(14)	10668631	283	133	247	94	194	15	7	39	28	0	0.000227	1.000	1.000
183	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C8B(47), C9(22), MASP1(20)	8278889	347	133	313	152	263	15	11	28	26	4	0.00453	1.000	1.000
184	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(27), ATP4A(17), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), COX10(8), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA13(4), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFC2(2), NDUFS1(2), NDUFS2(3), NDUFS3(5), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(1), NDUFV2(1), NDUFV3(5), PPA1(1), PPA2(4), SDHA(4), SDHC(5), SDHD(2), TCIRG1(6), UQCRC1(4), UQCRC2(3), UQCRFS1(3)	23869939	283	132	275	141	163	26	16	45	30	3	0.186	1.000	1.000
185	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GCNT1(6), GCNT3(8), GCNT4(3), OGT(9), ST3GAL1(8), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(46)	13764968	286	132	269	132	194	15	8	33	36	0	0.0787	1.000	1.000
186	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(39), AR(10), ESR1(6), ESR2(10), ESRRA(3), HNF4A(26), NPM1(4), NR0B1(3), NR1D1(1), NR1D2(11), NR1H2(5), NR1H3(5), NR1I2(5), NR1I3(7), NR2C2(1), NR2E1(8), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(10), NR5A2(23), PGR(16), PPARA(8), PPARD(3), PPARG(12), RARA(5), RARB(9), RARG(3), ROR1(15), RORA(8), RORC(15), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3)	17788226	334	132	318	168	232	26	11	26	39	0	0.0451	1.000	1.000
187	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(15), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), MAP2K1(18), MAPK1(4), MAPK3(3), NR1I3(7), PAK1(4), PDE3A(30), PDE3B(6), PI3(6), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), RIPK3(10), VASP(3)	20646859	294	132	267	132	199	23	12	28	31	1	0.00494	1.000	1.000
188	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(8), GRB2(2), HRAS(6), JUN(1), LAT(3), LCK(17), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(4), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PTPN7(4), RAF1(12), RASA1(5), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(8)	20162906	283	132	265	130	174	29	10	36	31	3	0.323	1.000	1.000
189	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(7), BAD(4), BAK1(2), BAX(5), BCL2(3), BCL2L11(8), BIRC2(6), BIRC3(7), BIRC5(3), BNIP3L(1), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), GZMB(4), HELLS(6), IKBKB(4), IRF1(2), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(14), IRF7(5), JUN(1), LTA(5), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(12), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFSF10(10), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5)	24040874	296	131	291	169	189	30	16	29	31	1	0.705	1.000	1.000
190	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22), MASP1(20), MASP2(11), MBL2(14)	8493602	325	131	296	140	249	13	8	25	26	4	0.00350	1.000	1.000
191	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(15), BTK(15), CALM1(1), CALM2(1), CD79A(4), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP3K1(4), MAPK14(5), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19)	16111141	263	130	244	124	169	17	9	33	33	2	0.355	1.000	1.000
192	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), AMDHD1(6), AOC2(9), AOC3(9), ASPA(3), CARM1(7), CNDP1(10), DDC(16), FTCD(4), HAL(14), HARS(8), HARS2(4), HDC(25), HEMK1(4), HNMT(3), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), PRPS1(3), PRPS2(3), UROC1(17), WBSCR22(2)	16840005	269	130	258	162	165	24	15	27	36	2	0.438	1.000	1.000
193	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(26), ELK1(3), GNAS(33), GNB1(1), GRB2(2), HRAS(6), IGF1R(15), ITGB1(7), KLK2(5), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(30), RAF1(12), RPS6KA1(11), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(11)	14040067	271	128	251	116	165	29	13	43	21	0	0.0501	1.000	1.000
194	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(12), ALOX12(6), ALOX15(11), ALOX5(14), CBR3(1), CYP4F2(17), CYP4F3(26), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(12), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(49)	11883679	330	128	321	182	229	31	5	25	39	1	0.0174	1.000	1.000
195	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(10), OGDHL(44), PIPOX(7), PLOD1(6), PLOD2(7), PLOD3(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SETD1A(27), SETD7(2), SETDB1(10), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2)	24660651	310	127	299	148	202	27	16	39	25	1	0.0714	1.000	1.000
196	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(3), CHUK(2), DAXX(10), EGF(22), EGFR(26), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(6), IKBKB(4), JUN(1), MAP2K1(18), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), NFKB1(6), NFKBIA(2), PPP2CA(1), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), RAF1(12), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	20867948	291	127	275	169	178	25	9	34	45	0	0.725	1.000	1.000
197	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(21), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), SOAT2(6), SRD5A1(3)	9931614	250	126	221	97	169	20	15	22	23	1	0.000181	1.000	1.000
198	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(1), DHX58(3), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), FPGS(3), GGH(4), IFIH1(10), MOV10L1(25), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4)	26610983	279	126	269	157	177	19	17	27	38	1	0.701	1.000	1.000
199	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	A4GALT(7), B3GALNT1(6), B3GALT1(15), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), GBGT1(4), GCNT2(7), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGX(2), PIGZ(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12), UGCG(1)	20326358	257	126	252	141	143	29	12	42	30	1	0.284	1.000	1.000
200	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(4), AKT2(8), AKT3(3), ARHGEF11(23), BCL2(3), CDC42(2), DLG4(7), GNA13(1), LPA(59), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(3), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PI3(6), PIK3CB(10), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RDX(4), ROCK1(6), ROCK2(14), SERPINA4(22), SRF(3), TBXA2R(5)	20876814	273	126	260	152	157	23	11	45	37	0	0.832	1.000	1.000
201	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ARG2(2), ASL(9), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), EPRS(13), GAMT(5), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(2), NOS1(77), NOS3(20), OAT(4), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), PRODH(2), PYCR1(1), PYCR2(1), RARS(7), RARS2(4)	15270113	270	125	256	143	181	26	11	19	31	2	0.162	1.000	1.000
202	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(7), ARRB2(8), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CLCA1(8), CLCA2(9), CLCA4(30), CNGA3(25), CNGA4(18), CNGB1(23), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(11), PDC(6), PDE1C(54), PRKACA(3), PRKACB(4), PRKACG(10), PRKG1(15), PRKG2(16), PRKX(3)	12882005	299	125	279	162	201	24	9	31	34	0	0.133	1.000	1.000
203	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(4), AKT2(8), AKT3(3), BRD4(24), CAP1(2), CBL(10), CDC42(2), F2RL2(8), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), LNPEP(11), MAPK1(4), MAPK3(3), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN1(4), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SERPINB6(5), SFN(2), SHC1(2), SLC2A4(8), SORBS1(16), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	24841631	273	125	266	139	151	34	15	43	29	1	0.599	1.000	1.000
204	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), JUN(1), MAP2K1(18), MAPK3(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RAF1(12), RPS6KA3(2), SYT1(23)	14838618	263	124	241	130	165	26	13	32	26	1	0.365	1.000	1.000
205	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22)	6873265	280	123	253	119	212	11	7	24	22	4	0.00713	1.000	1.000
206	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(7), APAF1(7), ARHGDIB(4), BAG4(3), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), GSN(8), LMNA(5), LMNB1(2), LMNB2(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK8(3), MDM2(4), NFKB1(6), NFKBIA(2), NUMA1(11), PAK2(9), PRKCD(5), PRKDC(22), PSEN1(3), PSEN2(2), PTK2(7), RASA1(5), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2)	29446534	256	123	250	134	123	28	16	48	38	3	0.690	1.000	1.000
207	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(8), ACTN2(21), BCAR1(5), BCR(14), CAPN1(5), CAPNS1(3), CAPNS2(1), CAV1(1), CRKL(2), CSK(1), FYN(8), GRB2(2), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MAPK8(3), PPP1R12B(10), PTK2(7), PXN(2), RAF1(12), RAP1A(1), ROCK1(6), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(9), ZYX(8)	19904213	226	123	213	116	120	27	13	36	29	1	0.378	1.000	1.000
208	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(24), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14)	15779632	244	123	232	119	166	17	13	25	22	1	0.119	1.000	1.000
209	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(6), BCR(14), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8IP3(9), PAPPA(59), RPS6KA1(11), RPS6KA3(2), SHC1(2), SOS1(10), SYK(15), VAV1(19), VAV2(5), VAV3(11)	13394578	232	123	214	147	158	16	4	25	27	2	0.922	1.000	1.000
210	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), ELAVL1(1), FLT1(42), FLT4(31), HIF1A(4), HRAS(6), KDR(57), NOS3(20), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PXN(2), SHC1(2), VHL(4)	14545807	229	121	215	114	149	21	3	29	26	1	0.368	1.000	1.000
211	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(27), ATF2(6), AXIN1(10), BMP10(14), BMP2(7), BMP4(5), BMP5(33), BMP7(5), BMPR1A(2), BMPR2(7), CHRD(21), CTNNB1(17), DVL1(1), FZD1(5), GATA4(5), GSK3B(3), MAP3K7(1), MEF2C(5), MYL2(9), NKX2-5(1), NOG(2), NPPA(5), NPPB(6), RFC1(5), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), WNT1(2)	15445587	233	120	215	103	149	21	10	21	32	0	0.194	1.000	1.000
212	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(7), ENPP7(6), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(3), SMPD2(2), SMPD3(9), SMPD4(6), SPHK1(2), SPHK2(8), SPTLC1(2), SPTLC2(8), UGCG(1), UGT8(8)	15130294	257	120	250	166	178	17	6	30	26	0	0.840	1.000	1.000
213	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), HRH1(15), HRH2(3), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11)	10392292	276	120	252	212	179	32	11	27	25	2	0.0806	1.000	1.000
214	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(48), NCF2(8), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLD1(15), PPP1R12B(10), RALBP1(3), RPS6KB1(4), TRIO(23), VAV1(19), WASF1(5)	14739970	221	120	210	118	138	17	9	27	28	2	0.556	1.000	1.000
215	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(13), F2R(8), F2RL3(5), GNAI1(2), GNB1(1), HRAS(6), ITGA1(23), ITGB1(7), MAP2K1(18), MAPK1(4), MAPK3(3), PLA2G4A(16), PLCB1(61), PRKCA(9), PTGS1(20), PTK2(7), RAF1(12), SRC(2), SYK(15), TBXAS1(16)	10372786	248	120	225	102	164	19	7	30	27	1	0.0135	1.000	1.000
216	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(19), CALCR(19), CALCRL(19), CD97(7), CRHR1(9), CRHR2(5), ELTD1(27), EMR1(35), EMR2(6), GHRHR(12), GIPR(4), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(50), LPHN3(24), SCTR(8), VIPR1(8), VIPR2(7)	11248894	298	119	277	181	213	21	9	16	39	0	0.101	1.000	1.000
217	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(5), GHR(43), GRB2(2), HRAS(6), INSR(23), IRS1(5), JAK2(8), MAP2K1(18), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTPN6(5), RAF1(12), RPS6KA1(11), SHC1(2), SLC2A4(8), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(5)	14139891	209	118	190	99	128	17	12	29	22	1	0.203	1.000	1.000
218	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(12), ACAA1(6), ACAA2(1), ACADM(5), ACADS(6), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), AOX1(29), AUH(2), BCAT1(13), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HADHB(6), HIBADH(5), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), OXCT2(5), PCCA(5), PCCB(3)	18392272	237	118	227	111	154	20	14	25	24	0	0.220	1.000	1.000
219	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(3), FUCA1(3), GALNS(5), GBA(7), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NAGLU(4), NEU1(6), NEU2(19), NEU3(5), NEU4(16), SPAM1(28)	14580267	254	118	249	133	178	22	5	25	23	1	0.184	1.000	1.000
220	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(3), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(12), ARHGEF1(2), ARHGEF11(23), ARHGEF5(17), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), BAIAP2(8), CFL1(2), DIAPH1(10), GSN(8), LIMK1(5), MYL2(9), MYLK(48), OPHN1(4), PIP5K1A(7), PIP5K1B(21), PPP1R12B(10), ROCK1(6), SRC(2), TLN1(12), VCL(9)	19184854	249	118	239	123	175	14	10	25	25	0	0.0772	1.000	1.000
221	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(13), DIAPH1(10), FYN(8), GSN(8), HRAS(6), ITGA1(23), ITGB1(7), MAP2K1(18), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PIK3CA(10), PIK3R1(4), PTK2(7), PXN(2), RAF1(12), ROCK1(6), SHC1(2), SRC(2), TLN1(12)	15890305	214	117	193	98	132	16	8	34	23	1	0.237	1.000	1.000
222	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(6), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), RFT1(5), RPN2(4), ST6GAL1(8), STT3B(5)	18038343	210	117	203	110	124	22	14	22	27	1	0.257	1.000	1.000
223	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(2), BLVRB(1), CP(14), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UROS(1)	11766354	231	117	209	104	158	20	12	15	24	2	0.0382	1.000	1.000
224	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(10), EGF(22), EGFR(26), GRB2(2), HRAS(6), MAP2K1(18), MAPK1(4), MAPK3(3), PTPRB(97), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), SRC(2)	10643027	246	117	221	106	164	21	6	28	27	0	0.172	1.000	1.000
225	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(6), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), PPARA(8), RELA(4), TIRAP(1), TLR10(13), TLR2(15), TLR3(11), TLR4(42), TLR6(7), TLR7(17), TLR9(18), TOLLIP(1), TRAF6(4)	15464628	209	117	202	102	138	19	9	23	20	0	0.161	1.000	1.000
226	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(55), C5(23), C6(72), C7(49), C9(22)	4796342	221	115	195	88	165	6	6	21	19	4	0.0108	1.000	1.000
227	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(12), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), ATP6V0C(3), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(9), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), MAOA(4), MAOB(13), PEMT(3), PISD(2), PLCB2(12), PLCG1(9), PLCG2(30), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5)	17475585	249	115	242	154	167	19	12	19	32	0	0.467	1.000	1.000
228	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(27), AXIN1(10), CCND1(2), CD14(6), CTNNB1(17), DVL1(1), FZD1(5), GJA1(10), GNAI1(2), GSK3B(3), IRAK1(5), LBP(10), LEF1(4), LY96(4), MYD88(4), NFKB1(6), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4), TIRAP(1), TLR4(42), TOLLIP(1), WNT1(2)	12985566	190	115	181	100	115	17	11	24	21	2	0.717	1.000	1.000
229	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(7), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(14), EDN1(9), EDNRA(12), EDNRB(7), HPGD(2), HSD11B1(14), HSD11B2(2), PLA2G4A(16), PRL(3), PTGDR(12), PTGDS(4), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), PTGIS(18), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16)	8729408	222	115	213	87	151	23	6	20	21	1	4.59e-05	1.000	1.000
230	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CRK(3), CXCL12(8), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(6), MAP2K1(18), MAPK1(4), MAPK3(3), NFKB1(6), PIK3C2G(56), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PTK2B(12), PXN(2), RAF1(12), RELA(4)	11701273	190	114	165	100	125	13	6	29	16	1	0.542	1.000	1.000
231	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(5), AARS2(3), ABAT(12), ACY3(4), ADSL(6), ADSS(2), ADSSL1(9), AGXT(12), ASL(9), ASNS(9), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(9), DLAT(4), DLD(3), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(5), PDHA2(20), PDHB(1)	15732636	223	114	215	124	150	22	12	18	21	0	0.304	1.000	1.000
232	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(12), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CYP2C19(40), CYP2C9(41), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1)	13220609	199	113	187	118	124	21	14	18	22	0	0.791	1.000	1.000
233	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(3), CARS(9), CARS2(4), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(8), HARS2(4), IARS(10), IARS2(18), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(4), SARS(5), SARS2(3), TARS(5), TARS2(8), VARS(16), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2)	23310231	227	113	215	126	133	25	9	26	32	2	0.700	1.000	1.000
234	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFAT5(11), PDE6A(15), PDE6B(16), PDE6C(25), PDE6D(2), PDE6G(2), SLC6A13(31), TF(16)	15180327	230	113	215	135	158	11	6	19	36	0	0.184	1.000	1.000
235	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(26), ELK1(3), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PAK1(4), PRKCA(9), PTK2(7), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23)	14071241	209	112	190	119	131	18	10	29	20	1	0.870	1.000	1.000
236	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(25), CD2(29), CD33(21), CD5(8), CD7(2), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(25), TLR2(15), TLR4(42), TLR7(17), TLR9(18)	7912106	234	112	217	116	166	21	11	14	22	0	0.000181	1.000	1.000
237	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(5), CAPN2(6), CAPNS1(3), CAPNS2(1), CXCR3(4), EGF(22), EGFR(26), HRAS(6), ITGA1(23), ITGB1(7), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12)	13847150	219	112	210	129	143	14	10	22	30	0	0.552	1.000	1.000
238	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35)	7546020	191	112	166	93	136	17	11	8	18	1	0.0536	1.000	1.000
239	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TAT(21), TPO(49)	9341657	214	112	208	146	148	22	7	12	25	0	0.531	1.000	1.000
240	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(15), DLG4(7), EPHB2(36), F2(13), F2RL1(9), F2RL2(8), F2RL3(5), JUN(1), MAP2K5(5), MAPK1(4), MAPK7(4), MAPK8(3), MYEF2(4), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RAF1(12), RASAL1(18), SRC(2), TEC(13), VAV1(19)	11671726	209	112	201	142	123	23	6	31	23	3	0.959	1.000	1.000
241	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), AOX1(29), BCAT1(13), BCKDHA(1), BCKDHB(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), HIBADH(5), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), PCCA(5), PCCB(3), SDS(3)	15396124	206	112	196	97	135	16	10	22	23	0	0.234	1.000	1.000
242	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(11), ITGB3(25), MAPK1(4), MAPK3(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCB1(61), PRKCA(9), PTK2(7), SMPD1(3), SMPD2(2), SPHK1(2), SRC(2)	11555407	217	111	207	87	150	13	8	24	21	1	0.00491	1.000	1.000
243	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(12), ACACA(24), ACACB(23), ACADM(5), ACAT2(1), ACSS1(2), ACSS2(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SUCLG1(4), SUCLG2(3)	16979753	193	111	185	103	115	15	17	23	23	0	0.499	1.000	1.000
244	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), AOC2(9), AOC3(9), ASPA(3), CNDP1(10), DDC(16), HAL(14), HARS(8), HDC(25), HNMT(3), MAOA(4), MAOB(13), PRPS1(3), PRPS2(3)	10368931	194	110	183	111	119	14	10	20	30	1	0.289	1.000	1.000
245	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), NAT6(5), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(21), TPO(49)	14603732	224	110	218	158	154	21	11	14	24	0	0.952	1.000	1.000
246	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(37), ACE2(6), AGT(8), AGTR1(10), AGTR2(10), ANPEP(25), CMA1(6), CPA3(23), CTSA(4), CTSG(5), ENPEP(46), LNPEP(11), MAS1(4), MME(25), NLN(5), REN(12), THOP1(6)	8991146	243	110	227	124	169	20	11	14	28	1	0.0266	1.000	1.000
247	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), SELE(33), SELL(12), SELP(38)	6733714	211	110	199	83	153	7	6	18	25	2	0.00690	1.000	1.000
248	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(10), IL13RA1(4), IL2RG(3), IL4(1), IL4R(18), INPP5D(39), JAK1(7), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(4), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(9), TYK2(9)	15692547	224	110	213	108	146	17	9	29	22	1	0.338	1.000	1.000
249	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(34), AKT1(4), BAD(4), BAX(5), BCL2(3), CSF2RB(25), IGF1(11), IGF1R(15), IL3(3), IL3RA(8), KIT(13), KITLG(10), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	9343573	176	109	168	103	111	19	11	16	18	1	0.521	1.000	1.000
250	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(4), BAD(4), BCL2(3), CBL(10), CFLAR(5), CRKL(2), E2F1(6), FOS(2), GRB2(2), HRAS(6), IL2RA(7), IL2RB(12), IL2RG(3), IRS1(5), JAK1(7), JAK3(11), MAPK1(4), MAPK3(3), MYC(5), NMI(4), PIK3CA(10), PIK3R1(4), PPIA(1), PTPN6(5), RAF1(12), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(5), SYK(15)	15355772	178	109	173	104	100	22	11	24	20	1	0.847	1.000	1.000
251	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(16), CARM1(7), CCND1(2), CREBBP(24), EP300(19), ERCC3(6), ESR1(6), GRIP1(13), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), MEF2C(5), NCOR2(28), NR0B1(3), NRIP1(10), PELP1(14), POLR2A(14), TBP(4)	19402795	210	108	207	92	134	12	12	34	18	0	0.175	1.000	1.000
252	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ADC(5), AGMAT(4), ALDH18A1(8), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), ASS1(8), CPS1(29), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(5), SRM(1)	12448901	174	108	168	94	96	17	10	23	28	0	0.345	1.000	1.000
253	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(7), ACTG2(6), ADCY3(3), ADCY9(11), AK1(1), ARF4(3), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(33), PDIA4(5), PLCG1(9), PLCG2(30), PRKCA(9), SEC61A1(3), SEC61A2(2), TRIM23(2)	15808781	216	108	208	128	142	12	10	24	28	0	0.443	1.000	1.000
254	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(6), CDC42(2), DAXX(10), DDIT3(3), ELK1(3), GRB2(2), HMGN1(3), HRAS(6), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MYC(5), PLA2G4A(16), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2)	15328745	186	108	181	75	115	16	7	26	22	0	0.117	1.000	1.000
255	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(53), CR2(36), FCGR2B(3), HLA-DRA(13), HLA-DRB1(5), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36)	6426148	196	107	186	78	127	15	7	15	27	5	0.0269	1.000	1.000
256	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(26), EEF1A2(10), EEF1B2(1), EEF1D(7), EEF1G(6), EEF2(3), EEF2K(6), EIF1AX(3), EIF1AY(1), EIF2AK1(4), EIF2AK2(6), EIF2AK3(13), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G3(19), EIF5(2), EIF5B(4), ETF1(2), GSPT2(9), PABPC1(5), PABPC3(8), PAIP1(9), SLC35A4(4)	18614061	187	107	186	95	107	24	13	19	24	0	0.675	1.000	1.000
257	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(12), STON1(22), TAF1(15), TAF13(1), TAF1L(57), TAF2(9), TAF4(11), TAF4B(7), TAF5L(4), TAF6(4), TAF6L(4), TAF7(3), TAF7L(12), TAF9(3), TAF9B(1), TBPL1(1), TBPL2(8)	15433182	206	106	201	90	140	14	8	25	19	0	0.280	1.000	1.000
258	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(27), ATP4B(1), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(13), ATP7B(23), COX10(8), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1), PPA2(4), SDHA(4), SHMT1(2), UQCRC1(4), UQCRFS1(3)	16344614	198	106	196	119	116	12	18	29	21	2	0.800	1.000	1.000
259	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(27), AXIN1(10), CREBBP(24), CTNNB1(17), DVL1(1), EP300(19), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(4), PITX2(6), TRRAP(47), WNT1(2)	14184657	170	106	164	93	91	16	13	24	25	1	0.890	1.000	1.000
260	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(12), ACACA(24), ACADL(5), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), LDHA(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SDS(3), SUCLG1(4), SUCLG2(3)	14168861	177	106	169	79	112	13	12	23	17	0	0.164	1.000	1.000
261	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(4), AKT2(8), AKT3(3), BAD(4), BTK(15), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(10), IGFBP1(3), INPP5D(39), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	14749762	192	106	179	83	121	16	11	25	18	1	0.211	1.000	1.000
262	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(12), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(3), PHGDH(5), PIPOX(7), PISD(2), PSAT1(4), PSPH(2), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SARDH(20), SARS(5), SARS2(3), SDS(3), SHMT1(2), SHMT2(3), TARS(5), TARS2(8)	17771881	241	105	235	150	165	18	10	15	33	0	0.553	1.000	1.000
263	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(7), BAD(4), BAX(5), BCL2(3), BCL2A1(2), BCL2L2(3), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(1), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKE(9), LTA(5), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(17), RIPK1(3), TFG(1), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4)	18464851	204	104	201	131	127	19	9	24	24	1	0.972	1.000	1.000
264	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(10), ABAT(12), ACADS(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(20), PDHB(1), SDS(3)	11044883	181	104	172	74	116	17	7	20	21	0	0.00967	1.000	1.000
265	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CMBL(5), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), PON1(15), PON2(3), PON3(6)	7664834	202	104	191	75	145	12	6	12	26	1	3.57e-05	1.000	1.000
266	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(27), CAMP(2), CASP3(3), CERK(1), CREB3(1), CREB5(9), DAG1(9), EPHB2(36), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4)	12137477	163	104	158	98	106	11	8	16	21	1	0.862	1.000	1.000
267	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(4), ATF1(5), CDC42(2), CREB3(1), CREB5(9), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(13), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(7), MKNK2(4), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4)	14189558	177	104	170	102	113	17	3	23	21	0	0.719	1.000	1.000
268	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(13), BCAT2(1), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), ILVBL(5), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14), VNN1(7)	7364067	196	103	174	56	143	11	3	21	18	0	4.84e-06	1.000	1.000
269	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8)	9695157	218	102	208	104	140	22	11	21	23	1	0.114	1.000	1.000
270	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8)	9695157	218	102	208	104	140	22	11	21	23	1	0.114	1.000	1.000
271	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(22), EGFR(26), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3)	15968694	186	102	174	94	104	18	8	33	22	1	0.769	1.000	1.000
272	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(4), AVP(1), CABIN1(17), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), HDAC5(6), IGF1(11), IGF1R(15), INSR(23), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1), NFATC1(18), NFATC2(12), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(23)	14860672	204	102	192	111	134	19	10	23	17	1	0.371	1.000	1.000
273	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), GLCE(8), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(51)	8709189	176	102	171	96	112	13	8	20	23	0	0.238	1.000	1.000
274	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ATP6V0C(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADHA(6), PLOD1(6), PLOD2(7), PLOD3(5), SDS(3), SHMT1(2), SHMT2(3), TMLHE(2)	15709863	176	102	168	91	113	18	7	21	16	1	0.220	1.000	1.000
275	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(34), ARHGEF1(2), F2(13), F2R(8), F2RL3(5), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(4), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2B(12), ROCK1(6)	11017213	188	102	177	91	124	15	8	23	16	2	0.181	1.000	1.000
276	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), PAK1(4), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23)	11951296	162	102	145	90	95	15	8	25	19	0	0.782	1.000	1.000
277	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(3), CDK2(1), CDT1(3), DIAPH2(9), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), NACA(44), PCNA(2), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(3), RFC1(5), RFC2(4), RFC3(1), RPA1(3), RPA2(2), RPA4(2), UBB(1), UBC(6)	21570075	180	101	177	112	122	13	7	25	13	0	0.889	1.000	1.000
278	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), GNAS(33), GRB2(2), HRAS(6), MAPK1(4), MAPK14(5), MAPK3(3), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RPS6KA1(11), RPS6KA5(7), SOS1(10)	12178266	193	100	186	107	123	20	9	19	21	1	0.703	1.000	1.000
279	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(12), ACO1(8), ACO2(5), CLYBL(5), CS(2), DLD(3), DLST(1), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), OGDHL(44), PC(14), PCK1(28), PCK2(6), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3)	12781489	190	100	172	91	127	7	7	27	22	0	0.0730	1.000	1.000
280	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(10), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), FUK(8), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), HSD3B7(5), KHK(2), LHPP(1), MPI(2), MTMR1(6), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(6), PFKFB3(5), PFKFB4(8), PFKL(3), PFKM(2), PFKP(2), PGM2(7), PMM1(4), PMM2(3), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SORD(2), TPI1(1), TSTA3(4)	15743248	172	100	167	122	109	15	14	18	16	0	0.826	1.000	1.000
281	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3)	5638748	148	100	128	47	106	10	11	11	10	0	7.06e-05	1.000	1.000
282	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL1RN(8), IL6(2), IRAK1(5), IRAK2(15), IRAK3(11), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	12575253	139	100	134	78	88	12	4	15	20	0	0.581	1.000	1.000
283	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(15), ABCC2(12), ABCG2(5), BCHE(7), CES1(21), CES2(4), CYP3A4(21), CYP3A5(14), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16)	9767425	208	100	188	90	141	17	11	17	20	2	0.00128	1.000	1.000
284	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3)	14868996	171	100	159	75	94	17	7	34	18	1	0.366	1.000	1.000
285	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(10), F2(13), F2R(8), F3(2), F5(39), F7(7), FGA(42), FGB(10), FGG(10), PROC(11), PROS1(17), SERPINC1(7), TFPI(8)	6998214	184	99	170	72	124	19	8	19	13	1	0.0485	1.000	1.000
286	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(12), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EARS2(2), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GFPT2(9), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSR(2), GSS(9), NADSYN1(4), NAGK(1), QARS(6)	16849083	198	99	191	112	114	24	11	28	20	1	0.611	1.000	1.000
287	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(3), CREBBP(24), EP300(19), FYN(8), IL2RG(3), IL7(5), IL7R(37), JAK1(7), JAK3(11), LCK(17), NMI(4), PIK3CA(10), PIK3R1(4), PTK2B(12), STAT5A(3), STAT5B(5)	11900062	172	99	167	86	103	20	8	23	16	2	0.470	1.000	1.000
288	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(13), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14)	5933233	183	99	161	51	131	11	3	21	17	0	3.53e-05	1.000	1.000
289	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(7), BAK1(2), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(5), FASLG(15), GZMB(4), JUN(1), MAP2K4(4), MAP3K1(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), PARP1(8), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(10), TRAF1(6), TRAF2(2)	15536074	168	98	166	80	98	18	11	19	22	0	0.306	1.000	1.000
290	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(26), F2(13), F2R(8), FGA(42), FGB(10), FGG(10), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6)	5693092	180	98	171	69	126	12	10	18	13	1	0.0350	1.000	1.000
291	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(16), ATR(22), BRCA1(16), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(4), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(19), MDM2(4), MYT1(21), PRKDC(22), RPS6KA1(11), WEE1(2), YWHAQ(3)	17533576	164	98	161	76	100	14	8	29	13	0	0.638	1.000	1.000
292	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME3(8), PGK1(3), PGK2(36), PKLR(14), TKT(6), TKTL1(3), TKTL2(28), TPI1(1)	8638255	170	98	157	95	124	17	5	13	10	1	0.0732	1.000	1.000
293	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PIK3CB(10), PITX2(6), PLD1(15), PLD2(8), PLD3(1), VN1R1(1)	19078956	184	98	176	124	104	16	13	28	23	0	0.868	1.000	1.000
294	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(20), FOS(2), HRAS(6), JUN(1), MAP2K1(18), MAPK1(4), MAPK3(3), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RAF1(12), RELA(4), TNF(1)	6642738	154	97	133	58	106	10	7	16	15	0	0.00314	1.000	1.000
295	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(9), CHAT(20), COMT(4), DBH(16), DDC(16), GAD1(14), GAD2(9), HDC(25), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(11), TPH1(12)	6036350	159	95	150	98	113	14	6	6	19	1	0.221	1.000	1.000
296	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(8), AZIN1(1), BTG1(5), CBX3(2), CLOCK(4), CRY1(7), CRY2(7), EIF4G2(6), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(15), NCKAP1(5), NCOA4(4), NR1D2(11), PER1(8), PER2(12), PIGF(3), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(2), SF3A3(7), SUMO3(2), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(10)	15560924	181	95	178	81	93	18	16	33	21	0	0.530	1.000	1.000
297	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(4), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), GHR(43), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(3), MKNK1(7), PABPC1(5), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PRKCA(9), RPS6KB1(4)	11724819	164	95	154	61	98	22	8	16	19	1	0.0467	1.000	1.000
298	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(3), ARSD(3), ARSE(5), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SMPD1(3), SMPD2(2), SPTLC1(2), SPTLC2(8), UGCG(1)	10226157	182	95	177	111	122	15	3	22	20	0	0.773	1.000	1.000
299	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), BTRC(4), CDC20(1), CDC23(4), CDC27(14), CUL1(3), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(8), ITCH(9), SKP2(3), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(7), WWP2(9)	16992013	161	95	156	75	102	8	8	19	23	1	0.692	1.000	1.000
300	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(7), BAIAP2(8), CASP1(4), CASP3(3), CASP7(4), CASP8(9), GAPDH(3), INSR(23), ITCH(9), MAGI1(38), MAGI2(24), RERE(25), WWP1(7), WWP2(9)	10275967	173	94	168	76	115	12	7	17	21	1	0.221	1.000	1.000
301	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(5), HLA-A(4), IL18(3), ITGB1(7), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LAT(3), MAP2K1(18), MAPK3(3), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2B(12), PTPN6(5), SYK(15), VAV1(19)	7727189	141	94	126	87	94	7	4	15	19	2	0.914	1.000	1.000
302	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(34), ADRB2(4), GNAS(33), PLCE1(60), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6249260	158	94	151	80	104	17	10	14	13	0	0.297	1.000	1.000
303	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(10), PDE1A(44), PDE1B(15), PLCB1(61), PLCB2(12), PRL(3), TRH(4), VIP(5)	4695304	160	94	140	66	122	5	2	14	17	0	0.00256	1.000	1.000
304	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK5(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(10), PIK3CD(8), PIK3R1(4), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	14273666	154	94	148	104	103	11	7	19	13	1	0.880	1.000	1.000
305	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), GSR(2), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(2), OPLAH(13), TXNDC12(1)	9340327	180	93	160	94	118	13	7	25	17	0	0.0472	1.000	1.000
306	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(5), BAD(4), CREB3(1), CREB5(9), DUSP4(4), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MOS(6), NFKB1(6), RAP1A(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), SHC1(2), SOS1(10), SOS2(13), TRAF3(5)	11899161	139	93	128	88	93	12	4	17	13	0	0.952	1.000	1.000
307	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(4), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CFLAR(5), DAXX(10), DFFA(2), DFFB(2), FAF1(9), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), PTPN13(17), RB1(10), RIPK2(3), SPTAN1(10)	17418966	157	92	156	84	71	15	13	32	24	2	0.910	1.000	1.000
308	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELE(33), SELL(12)	5121911	148	92	142	57	105	6	5	12	18	2	0.0296	1.000	1.000
309	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(34), CAP1(2), CDC25C(5), GNAI1(2), GNAS(33), GNB1(1), HRAS(6), MAPK1(4), MAPK3(3), MYT1(21), PIN1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(11), SRC(2)	8761289	156	92	150	95	105	16	8	13	14	0	0.614	1.000	1.000
310	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(13), ARHGEF1(2), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(48), PLCB1(61), PPP1R12B(10), PRKCA(9), ROCK1(6)	8853425	169	92	151	73	123	2	7	19	18	0	0.0829	1.000	1.000
311	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), GRB2(2), GSK3A(1), GSK3B(3), IL4R(18), IRS1(5), IRS2(3), JAK1(7), JAK3(11), MAP4K1(12), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PPP1R13B(9), RAF1(12), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(9)	15586079	171	92	169	87	95	25	7	26	17	1	0.532	1.000	1.000
312	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(34), ADRB2(4), CFTR(62), GNAS(33), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2)	5542558	162	91	150	90	108	14	7	14	18	1	0.448	1.000	1.000
313	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(7), BCL2(3), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(14), LMNA(5), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(5), TNFRSF25(6), TNFSF10(10), TNFSF12(1), TRAF2(2)	14242218	138	91	136	78	77	18	10	20	13	0	0.722	1.000	1.000
314	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), NAGLU(4), SPAM1(28)	8678408	160	91	156	96	115	11	3	15	16	0	0.653	1.000	1.000
315	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(9), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(18), IL5(4), TGFB1(2), TGFB2(4), TGFB3(3)	8508318	175	91	164	95	128	12	2	14	19	0	0.0299	1.000	1.000
316	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(6), CDK5R1(1), DAB1(48), FYN(8), LRP8(3), RELN(90), VLDLR(5)	5963173	161	91	154	89	114	9	3	16	18	1	0.888	1.000	1.000
317	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(22), EPHB1(31), FYN(8), ITGA1(23), ITGB1(7), L1CAM(11), LYN(11), RAP1B(1), SELP(38)	6728695	156	90	144	78	108	8	5	18	16	1	0.300	1.000	1.000
318	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(15), ATM(16), ATR(22), CCNA1(16), CCND1(2), CCNE1(4), CDC25A(8), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CDKN1B(2), DHFR(1), E2F1(6), GSK3B(3), HDAC1(2), RB1(10), SKP2(3), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3)	12244144	135	89	130	62	73	9	11	22	18	2	0.486	1.000	1.000
319	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(12), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GLS(2), GLS2(3), GLUD1(2), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSS(9), NADSYN1(4), QARS(6)	14165629	175	89	168	91	101	19	10	26	18	1	0.465	1.000	1.000
320	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL2(4), IL2RA(7), IL2RB(12), IL2RG(3), JAK1(7), JAK3(11), JUN(1), LCK(17), MAP2K1(18), MAPK3(3), MAPK8(3), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5), SYK(15)	9830354	148	89	136	73	90	13	6	23	16	0	0.313	1.000	1.000
321	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(4), BCL2(3), EGFR(26), IGF1R(15), MYC(5), POLR2A(14), PPP2CA(1), PRKCA(9), RB1(10), TEP1(36), TERF1(2), TERT(10), TNKS(10), XRCC5(2)	11652428	147	89	143	87	85	15	9	17	19	2	0.720	1.000	1.000
322	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2)	10680233	143	88	126	61	106	9	9	12	7	0	0.132	1.000	1.000
323	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GCNT1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), WBSCR17(46)	6180311	140	88	129	62	98	10	4	13	15	0	0.0629	1.000	1.000
324	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(18), NFATC2(12), NFKB1(6), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7)	11897942	152	88	145	93	97	12	8	17	18	0	0.878	1.000	1.000
325	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(16), ATR(22), BRCA1(16), BRCA2(24), CHEK1(2), CHEK2(2), FANCA(8), FANCC(2), FANCD2(16), FANCE(4), FANCG(7), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(6), RAD9A(6), TREX1(1)	18449843	148	87	145	74	97	7	5	18	21	0	0.862	1.000	1.000
326	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(11), AGT(8), AGTR2(10), EDN1(9), EDNRA(12), EDNRB(7), EGF(22), EGFR(26), FOS(2), HRAS(6), JUN(1), MYC(5), NFKB1(6), PLCG1(9), PRKCA(9), RELA(4)	8756081	147	87	144	77	100	10	8	13	15	1	0.278	1.000	1.000
327	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(13), EGF(22), EGFR(26), GRB2(2), MET(23), PDGFRA(32), PRKCA(9), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2)	8308320	148	87	146	91	97	9	5	18	19	0	0.890	1.000	1.000
328	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(12), CSF1R(13), DDX20(11), E2F1(6), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(6), JUN(1), NCOR2(28), RBL1(14), RBL2(6), SIN3A(11), SIN3B(8)	11072204	144	87	143	81	94	7	3	27	13	0	0.591	1.000	1.000
329	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(2), PGD(9)	7699562	146	87	129	69	91	11	7	22	15	0	0.0264	1.000	1.000
330	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(27), AXIN1(10), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(5), CSNK1D(3), CSNK2A1(2), CTNNB1(17), DVL1(1), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2)	12450768	133	87	130	73	66	11	12	20	24	0	0.926	1.000	1.000
331	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCL2(3), BCR(14), CRKL(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), MYC(5), PIK3CA(10), PIK3R1(4), RAF1(12), SOS1(10), STAT1(5), STAT5A(3), STAT5B(5)	11932026	128	86	117	58	67	15	8	20	17	1	0.440	1.000	1.000
332	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16)	8660488	160	86	157	82	116	16	2	14	11	1	0.173	1.000	1.000
333	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(2), ENPP6(14), PAFAH1B1(6), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PPAP2A(1), PPAP2B(11), PPAP2C(10)	9935487	168	86	162	86	104	13	5	22	22	2	0.291	1.000	1.000
334	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(1), POLR3K(1), TAF13(1), TAF6(4), TAF7(3), TAF9(3), TBP(4)	14984109	135	86	131	62	79	12	9	22	13	0	0.384	1.000	1.000
335	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(16), GRM1(13), PLCB1(61), PPP1CA(3), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6801342	147	85	138	94	108	4	6	13	15	1	0.624	1.000	1.000
336	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(3), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(4), TKT(6), TKTL1(3), TKTL2(28)	10337668	132	85	124	91	84	12	7	12	17	0	0.645	1.000	1.000
337	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(9), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(8), POLG2(7), POLH(4), POLI(2), POLK(7), POLL(10), POLM(2), POLQ(26), PRIM1(3), PRIM2(6), REV1(3), REV3L(18)	17244921	143	85	142	70	78	11	11	26	17	0	0.730	1.000	1.000
338	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(32), GSTP1(3)	6071115	159	85	147	75	106	17	5	12	18	1	0.00188	1.000	1.000
339	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PPARA(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(23)	8558172	136	85	129	78	96	9	5	12	14	0	0.372	1.000	1.000
340	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(10), CHIT1(12), CMAS(2), CTBS(6), CYB5R1(1), CYB5R3(2), GFPT1(6), GFPT2(9), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), NPL(2), PGM3(1), RENBP(3), UAP1(2)	12220567	122	84	120	81	75	10	6	19	12	0	0.940	1.000	1.000
341	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(24), DUSP1(1), EP300(19), IKBKB(4), IL1B(8), MAP2K3(9), MAP2K6(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(4), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1)	12666350	125	84	124	78	74	18	5	17	11	0	0.953	1.000	1.000
342	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(5), ABAT(12), ADSL(6), ADSS(2), AGXT(12), ASL(9), ASNS(9), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(9), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), PC(14)	10723068	151	83	147	92	102	16	8	12	13	0	0.429	1.000	1.000
343	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(34), GNAS(33), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6526432	144	83	137	66	97	14	8	9	16	0	0.172	1.000	1.000
344	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(4), BAG4(3), CASP2(1), CASP3(3), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MADD(18), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2)	16569459	133	83	131	71	64	10	13	22	20	4	0.751	1.000	1.000
345	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAPK3(3), MPL(9), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), THPO(10)	12747108	146	83	134	68	81	13	8	28	14	2	0.631	1.000	1.000
346	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(22), EGFR(26), MAP2K1(18), MAP3K1(4), MAPK14(5), NCOR2(28), RARA(5), RXRA(4), THRA(2), THRB(18)	7319734	132	82	121	65	91	11	3	13	14	0	0.282	1.000	1.000
347	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(10), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPHN(9), SRC(2), UBQLN1(5)	5015372	137	82	120	77	100	6	5	14	10	2	0.507	1.000	1.000
348	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), INSR(23), IRS1(5), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SLC2A4(8), SOS1(10), SRF(3)	10916626	132	82	119	61	63	18	6	31	13	1	0.635	1.000	1.000
349	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(27), CDH1(6), CREBBP(24), EP300(19), MAP2K1(18), MAP3K7(1), MAPK3(3), SKIL(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9)	10979411	119	82	110	56	64	14	7	18	16	0	0.791	1.000	1.000
350	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), GCK(16), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), KHK(2), MPI(2), PFKFB1(4), PFKFB3(5), PFKFB4(8), PFKM(2), PFKP(2), PMM1(4), PMM2(3), SORD(2), TPI1(1)	10151370	124	81	119	96	81	13	8	10	12	0	0.829	1.000	1.000
351	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(33), GNB1(1), NFKB1(6), NOS3(20), NPPA(5), NR3C1(7), PIK3CA(10), PIK3R1(4), RELA(4), SYT1(23)	7604428	130	81	121	58	89	13	5	18	4	1	0.282	1.000	1.000
352	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IGF1(11), IGF1R(15), IRS1(5), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3)	10568116	127	81	112	55	64	20	3	28	11	1	0.492	1.000	1.000
353	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(6), DYRK1B(2), GLI2(44), GLI3(19), GSK3B(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(3)	7088275	117	81	114	79	80	11	5	12	9	0	0.867	1.000	1.000
354	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(37), AGT(8), AGTR1(10), AGTR2(10), BDKRB2(10), KNG1(15), NOS3(20), REN(12)	4227401	122	80	117	73	81	8	6	10	15	2	0.141	1.000	1.000
355	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(27), PGAP1(9), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGW(1), PIGX(2), PIGZ(4)	10175297	127	80	124	56	72	9	7	27	12	0	0.0784	1.000	1.000
356	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(29), BST1(2), CD38(6), ENPP1(13), ENPP3(15), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(7), NMNAT3(11), NNMT(11), NNT(4), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT12(5), QPRT(6)	9184446	160	80	152	72	103	11	6	18	22	0	0.130	1.000	1.000
357	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(9), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), HAL(14)	8995302	135	80	130	71	93	10	5	16	11	0	0.473	1.000	1.000
358	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(3), STAT4(26), TYK2(9)	7913073	139	80	134	65	97	8	4	12	18	0	0.226	1.000	1.000
359	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(25), FOS(2), GRB2(2), HRAS(6), IL3(3), IL3RA(8), JAK2(8), MAP2K1(18), MAPK3(3), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5)	7495921	112	80	101	51	66	7	6	15	18	0	0.249	1.000	1.000
360	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(4), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), PC(14), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(6), PDK4(8), PDP2(5), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3)	12129700	129	80	126	64	82	7	8	15	17	0	0.344	1.000	1.000
361	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(4), EIF4A1(4), EIF4A2(3), EIF4B(6), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), MKNK1(7), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4), TSC1(9), TSC2(14)	11458530	121	80	117	51	64	17	7	15	16	2	0.277	1.000	1.000
362	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(13), BCAT2(1), IARS(10), IARS2(18), ILVBL(5), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1), VARS(16), VARS2(7)	8037888	114	79	105	54	76	12	3	11	12	0	0.340	1.000	1.000
363	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG3(2), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(32), ULK1(11), ULK2(7), ULK3(1)	8906155	135	79	129	72	94	8	6	15	12	0	0.423	1.000	1.000
364	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(3), CAT(8), EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49)	5044091	119	79	115	72	90	10	2	7	10	0	0.285	1.000	1.000
365	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(10), PIK3R1(4), PLCB1(61), PLCG1(9), PRKCA(9), VAV1(19)	5486267	116	79	107	59	87	5	2	9	11	2	0.332	1.000	1.000
366	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(8), ACTN2(21), CAPN1(5), CAPNS1(3), CAPNS2(1), ITGA1(23), ITGB1(7), ITGB3(25), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12)	11836369	130	79	128	68	80	12	7	14	16	1	0.0982	1.000	1.000
367	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	4123781	141	78	130	70	97	16	5	9	13	1	0.00254	1.000	1.000
368	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	4123781	141	78	130	70	97	16	5	9	13	1	0.00254	1.000	1.000
369	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL6(2), IL6R(3), IL6ST(11), JAK1(7), JAK2(8), JAK3(11), JUN(1), MAP2K1(18), MAPK3(3), PTPN11(10), RAF1(12), SHC1(2), SOS1(10), SRF(3), STAT3(11)	10150886	127	78	116	64	60	16	5	32	14	0	0.799	1.000	1.000
370	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16)	7028228	141	78	138	70	103	13	1	13	10	1	0.230	1.000	1.000
371	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SP1(5), SP3(1), SYT1(23)	8931852	129	77	121	56	83	13	7	11	14	1	0.190	1.000	1.000
372	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(4), BAD(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(6), MAP2K1(18), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RAF1(12), RALA(1), RALBP1(3), RALGDS(11), RELA(4), RHOA(3)	7884068	100	77	89	53	56	15	3	19	6	1	0.654	1.000	1.000
373	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), ACO2(5), CS(2), DLD(3), DLST(1), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), PC(14), PCK1(28), SDHA(4), SUCLG1(4), SUCLG2(3)	8838194	106	76	91	57	73	2	6	12	13	0	0.405	1.000	1.000
374	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(6), ALOX15(11), ALOX15B(9), ALOX5(14), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(13), PTGDS(4), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16)	6367246	144	76	140	82	95	13	4	15	17	0	0.0806	1.000	1.000
375	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTAP(5), MTFMT(2), MTR(12), SRM(1), TAT(21)	8928478	123	76	121	54	76	11	8	12	15	1	0.0657	1.000	1.000
376	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(17), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(3), CAPNS2(1), EP300(19), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(18), NFATC2(12), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SYT1(23)	10461393	131	76	124	59	84	8	9	14	16	0	0.239	1.000	1.000
377	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(4), IL1A(5), IL1R1(12), IRAK1(5), MAP3K1(4), MAP3K7(1), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(42), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	10247356	109	76	102	67	75	7	4	12	11	0	0.814	1.000	1.000
378	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(13), CNR2(6), DNMT1(19), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), TBXA2R(5)	4758781	114	76	109	86	78	16	4	8	8	0	0.358	1.000	1.000
379	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(9), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(8), IARS(10), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3)	13730362	132	75	126	62	78	13	6	17	16	2	0.302	1.000	1.000
380	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RB1(10), RELA(4), SP1(5)	8247701	94	75	83	48	46	12	4	13	16	3	0.763	1.000	1.000
381	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), NAT1(2), NAT2(10), XDH(61)	3426350	116	75	107	79	91	5	6	3	11	0	0.182	1.000	1.000
382	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(24), CPT1A(14), LEP(4), LEPR(31), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8)	6219439	121	75	113	58	83	5	3	11	19	0	0.483	1.000	1.000
383	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(9), TALDO1(4), TKT(6)	8709126	105	75	101	73	67	8	6	10	14	0	0.673	1.000	1.000
384	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(37), CD44(5), CSF1(12), FCGR3A(9), IL1B(8), IL6R(3), SELL(12), SPN(5), TGFB1(2), TGFB2(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3)	5536832	128	75	121	63	94	7	6	5	16	0	0.0715	1.000	1.000
385	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(6), MAP2K1(18), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10)	6825036	106	75	95	44	52	17	4	21	12	0	0.200	1.000	1.000
386	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(18), APOA1(1), APOA4(9), APOC1(3), APOC2(1), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(4), LDLR(19), LIPC(10), LPL(6), LRP1(47), SCARB1(5), SOAT1(3)	11782522	144	75	141	85	83	20	9	16	14	2	0.418	1.000	1.000
387	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(59), NRG2(9), NRG3(24), PRKCA(9), PSEN1(3)	3808560	105	74	94	39	76	5	3	6	15	0	0.0327	1.000	1.000
388	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPX1(3), PRKCE(7)	3305458	121	74	105	62	87	8	3	13	8	2	0.255	1.000	1.000
389	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(5), GLB1(10), HEXA(5), HEXB(4), LCT(54), SLC33A1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12)	7030462	134	74	132	82	90	12	1	19	12	0	0.600	1.000	1.000
390	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(8), EPX(9), LPO(20), MPO(12), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49)	4979106	113	74	109	72	88	9	1	7	8	0	0.398	1.000	1.000
391	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(20), AP2A1(2), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(10), EPN1(6), EPS15(4), NME1(1), PICALM(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(22), SYT1(23)	9128501	134	74	128	63	91	9	5	16	13	0	0.260	1.000	1.000
392	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(9), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(1), HAL(14)	8046098	120	74	116	66	83	7	4	16	10	0	0.597	1.000	1.000
393	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(12), SNCA(2), SNCAIP(67), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L3(1), UBE2L6(2)	2748962	104	74	93	36	79	10	3	5	7	0	0.0131	1.000	1.000
394	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TPO(49), TYR(11)	4120139	111	74	107	68	82	11	1	5	12	0	0.434	1.000	1.000
395	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1)	4542831	126	74	116	54	85	8	4	7	20	2	0.00854	1.000	1.000
396	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1)	4762451	133	74	122	59	89	8	4	8	22	2	0.0105	1.000	1.000
397	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(8), ACTN2(21), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(30), CTNNB1(17), PTK2(7), PXN(2), SRC(2), VCL(9)	8056585	105	73	100	61	63	8	8	12	13	1	0.408	1.000	1.000
398	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(34), FHL5(13), FSHB(9), FSHR(21), GNAS(33), XPO1(3)	4054852	113	73	104	51	77	12	6	8	10	0	0.192	1.000	1.000
399	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(4), CCND1(2), CCNE1(4), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CDKN1B(2), E2F1(6), HRAS(6), MAPK1(4), MAPK3(3), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(4), RAF1(12), RB1(10), RELA(4), TFDP1(2)	8412966	99	73	93	50	42	12	8	19	15	3	0.678	1.000	1.000
400	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), BAD(4), GRB2(2), HRAS(6), IGF1R(15), IRS1(5), MAP2K1(18), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), RAF1(12), SHC1(2), SOS1(10)	8115541	99	72	86	45	55	13	4	17	9	1	0.436	1.000	1.000
401	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(27), ITGAM(25), ITGB2(17), SELE(33), SELL(12)	4384333	121	72	120	60	87	6	3	6	17	2	0.0738	1.000	1.000
402	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(6), GTF2A1(2), GTF2B(5), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(19), NCOR2(28), POLR2A(14), RARA(5), RXRA(4), TBP(4)	10591405	122	72	119	55	94	4	5	10	9	0	0.194	1.000	1.000
403	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(6), HSPA1A(1), IFNG(4), IFNGR1(4), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(35), WT1(10)	7165911	107	72	100	42	54	10	4	13	24	2	0.113	1.000	1.000
404	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(15), ATM(16), BRCA1(16), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(3), MDM2(4), MRE11A(5), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(5), RELA(4), TP73(6)	12304033	96	71	95	48	47	12	3	19	15	0	0.904	1.000	1.000
405	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PGK1(3), PKLR(14), TKT(6), TPI1(1)	7718937	105	71	102	60	74	11	4	6	9	1	0.206	1.000	1.000
406	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(4), CAT(8), GH1(5), GHR(43), HRAS(6), IGF1(11), IGF1R(15), PIK3CA(10), PIK3R1(4), SHC1(2)	5668311	108	71	99	45	73	12	2	13	7	1	0.129	1.000	1.000
407	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(10), CD2(29), CD3D(7), CD3E(2), CD3G(1), CD4(9), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(9)	6208723	134	71	124	61	90	10	4	10	20	0	0.0639	1.000	1.000
408	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(4), BAX(5), BCL2(3), CASP8(9), CYCS(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFKB1(6), NSMAF(6), RAF1(12), RELA(4), RIPK1(3), SMPD1(3), TNFRSF1A(4), TRAF2(2)	8701488	98	70	88	48	56	9	5	15	13	0	0.529	1.000	1.000
409	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PLCG1(9), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5)	9098879	100	70	90	50	51	8	7	19	15	0	0.600	1.000	1.000
410	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(4), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MPST(2), SDS(3), SULT1B1(11), SULT1C2(7), SULT1C4(15), SULT4A1(11)	5361463	108	70	104	34	71	5	11	8	13	0	0.00140	1.000	1.000
411	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(7), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), METTL2B(5), METTL6(2), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SCLY(3), SEPHS1(2), SEPHS2(2), WBSCR22(2)	10680917	110	70	108	61	65	13	5	15	12	0	0.427	1.000	1.000
412	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), KLK2(5), MAP2K1(18), MAPK3(3), MAPK8(3), NGFR(8), PIK3CA(10), PIK3R1(4), PLCG1(9), RAF1(12), SHC1(2), SOS1(10)	8122631	101	70	90	47	52	12	3	22	11	1	0.591	1.000	1.000
413	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), BAD(4), CHRNB1(4), CHRNG(3), MUSK(38), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), RAPSN(1), SRC(2), TERT(10)	6942853	99	69	95	84	64	8	1	17	8	1	0.991	1.000	1.000
414	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(16), AOC2(9), AOC3(9), CES1(21), DDHD1(8), ESCO1(2), ESCO2(4), LIPA(5), NAT6(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2)	10815802	99	69	95	58	74	4	7	6	8	0	0.821	1.000	1.000
415	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(24), DAXX(10), HRAS(6), PAX3(3), PML(16), RARA(5), RB1(10), SIRT1(2), SP100(12), TNF(1), TNFRSF1A(4), TNFRSF1B(4)	7686287	97	69	97	42	42	15	7	14	17	2	0.332	1.000	1.000
416	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(7), CREBBP(24), EP300(19), NCOA3(19), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(5), RXRA(4)	8838285	105	68	105	57	63	8	5	17	12	0	0.846	1.000	1.000
417	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK2(1), CDK4(8), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), E2F1(6), RB1(10), RBL1(14), TFDP1(2)	6625827	92	67	88	32	47	5	8	18	12	2	0.0560	1.000	1.000
418	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(4), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), CASP3(3), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(9), PTK2(7), PXN(2), STAT1(5), TLN1(12)	11283078	85	67	82	52	48	10	5	12	10	0	0.891	1.000	1.000
419	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(39), AKT1(4), ATM(16), BAX(5), CDKN1A(3), CPB2(1), CSNK1A1(5), CSNK1D(3), HIC1(2), HIF1A(4), HSPA1A(1), IGFBP3(3), MAPK8(3), MDM2(4), NFKBIB(1), NQO1(2)	8512093	96	67	86	48	57	7	3	14	14	1	0.714	1.000	1.000
420	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(3), GSR(2), GSS(9), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(61)	4206671	99	66	94	52	72	8	4	7	8	0	0.140	1.000	1.000
421	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(7), LPO(20), MPO(12), PRDX6(4), TPO(49)	3577255	101	66	97	66	78	9	1	5	8	0	0.474	1.000	1.000
422	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(4), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(11), IGF1R(15), INPPL1(16), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4)	8036600	85	66	79	46	50	12	6	9	7	1	0.670	1.000	1.000
423	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(38), MAP2(22), PPP1CA(3), PPP2CA(1), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(7)	7722806	94	65	93	51	51	10	7	11	14	1	0.874	1.000	1.000
424	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(27), AXIN1(10), BTRC(4), CTNNB1(17), DLL1(3), DVL1(1), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(3), WNT1(2)	9023786	85	65	84	52	41	10	7	11	16	0	0.942	1.000	1.000
425	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(4), AP2A1(2), AP2M1(3), BAD(4), BTK(15), EEA1(3), GRASP(3), GSK3A(1), GSK3B(3), LYN(11), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PLCG1(9), PRKCE(7), PRKCZ(3), RAB5A(2), RPS6KB1(4), VAV2(5)	10372921	91	65	89	67	52	10	6	7	16	0	0.867	1.000	1.000
426	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), BAD(4), CASP9(2), CHUK(2), GH1(5), GHR(43), NFKB1(6), NFKBIA(2), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4)	5968669	92	64	85	50	61	9	5	10	6	1	0.729	1.000	1.000
427	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(10), SYT1(23)	4947143	96	64	90	70	65	8	3	9	11	0	0.853	1.000	1.000
428	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CTLA4(2), GRB2(2), HLA-DRA(13), HLA-DRB1(5), ICOS(3), IL2(4), ITK(25), LCK(17), PIK3CA(10), PIK3R1(4), PTPN11(10)	5166398	111	64	107	44	73	8	2	15	11	2	0.185	1.000	1.000
429	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), TYR(11)	6398037	101	64	97	32	65	7	5	7	17	0	0.0170	1.000	1.000
430	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1)	10017523	93	64	90	47	53	10	6	18	6	0	0.543	1.000	1.000
431	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(19), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(8)	8528020	99	64	96	63	63	11	3	11	11	0	0.692	1.000	1.000
432	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(29), CD38(6), ENPP1(13), ENPP3(15), NADSYN1(4), NMNAT1(1), NMNAT2(7), NNMT(11), NNT(4), NT5E(7), NT5M(2), QPRT(6)	6212326	105	64	98	47	65	9	5	12	14	0	0.214	1.000	1.000
433	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(5), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP4K2(7), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2)	10155954	77	64	77	46	45	10	3	8	10	1	0.710	1.000	1.000
434	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(7), CD3E(2), CD3G(1), CD4(9), FYN(8), HLA-DRA(13), HLA-DRB1(5), LCK(17), PTPRC(36), ZAP70(8)	3783076	106	64	100	41	71	8	3	9	14	1	0.0194	1.000	1.000
435	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(8), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), GAMT(5), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(5)	7380470	92	64	89	40	54	9	5	13	11	0	0.137	1.000	1.000
436	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(54), MPI(2), PGM1(8), PYGL(9), PYGM(14), TPI1(1), TREH(4)	5632350	97	63	96	73	70	7	2	11	7	0	0.753	1.000	1.000
437	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(3), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(2), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1)	9608800	81	63	81	54	43	7	7	14	10	0	0.860	1.000	1.000
438	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTR(12)	7512788	94	63	93	38	56	9	7	10	11	1	0.0419	1.000	1.000
439	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), FDXR(12), SHMT1(2)	6838473	94	63	93	51	55	4	7	13	15	0	0.341	1.000	1.000
440	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(7), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(4), PRF1(14), SCAP(12), SREBF1(5), SREBF2(10)	7765698	97	63	93	48	57	9	7	14	10	0	0.377	1.000	1.000
441	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(5), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2)	8161439	84	62	78	41	45	6	2	12	19	0	0.560	1.000	1.000
442	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(3), CCR5(10), CXCL12(8), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(3), PLCG1(9), PRKCA(9), PTK2B(12), SYT1(23)	5899387	96	62	89	75	64	7	5	13	7	0	0.946	1.000	1.000
443	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), IDS(9), IDUA(8), LCT(54), NAGLU(4)	6107486	109	62	107	62	81	9	0	10	9	0	0.466	1.000	1.000
444	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(24), ACACB(23), FASN(26), MCAT(2), OLAH(11), OXSM(2)	6754738	88	62	86	53	53	9	3	8	15	0	0.506	1.000	1.000
445	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(8), B3GAT2(3), B3GAT3(4), CHPF(4), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(9), DSE(20), XYLT1(12), XYLT2(5)	5811712	90	62	90	62	57	13	4	8	8	0	0.545	1.000	1.000
446	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(9), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(13), HLA-DRB1(5), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(4), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), LTA(5), PDGFA(1), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1)	5614094	114	62	111	58	75	5	3	11	20	0	0.0211	1.000	1.000
447	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(24), EP300(19), LPL(6), NCOA1(9), NCOA2(13), PPARG(12), RXRA(4)	7931311	87	62	84	36	52	11	4	12	8	0	0.395	1.000	1.000
448	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	82	61	81	47	46	3	7	12	14	0	0.504	1.000	1.000
449	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	82	61	81	47	46	3	7	12	14	0	0.504	1.000	1.000
450	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(5), GPR34(3), GPR39(12), GPR45(8), GPR65(14), GPR68(3), GPR75(6)	4172726	78	61	75	41	54	5	3	8	8	0	0.0139	1.000	1.000
451	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(6), COPS5(3), EDN1(9), EP300(19), EPO(5), HIF1A(4), JUN(1), LDHA(6), NOS3(20), P4HB(3), VHL(4)	7297451	89	61	86	41	57	5	5	10	12	0	0.562	1.000	1.000
452	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(3)	5173131	81	61	75	31	47	10	4	11	9	0	0.0233	1.000	1.000
453	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(7), ATM(16), BAX(5), BCL2(3), CCND1(2), CCNE1(4), CDK2(1), CDK4(8), CDKN1A(3), E2F1(6), MDM2(4), PCNA(2), RB1(10), TIMP3(5)	7337140	76	61	71	31	29	8	4	18	15	2	0.550	1.000	1.000
454	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	82	61	81	47	46	3	7	12	14	0	0.504	1.000	1.000
455	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(15), GPLD1(27), KDELR1(1), KDELR3(3)	6983853	81	60	79	46	41	7	3	17	13	0	0.690	1.000	1.000
456	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), GRB2(2), HRAS(6), MAPK1(4), MAPK3(3), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), RPS6KA1(11), SHC1(2)	8066485	92	60	89	63	55	14	5	9	8	1	0.923	1.000	1.000
457	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13)	4320806	97	60	97	46	66	7	2	6	15	1	0.0649	1.000	1.000
458	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(6), BIRC3(7), CASP3(3), CASP8(9), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	11547447	84	60	83	57	47	4	9	13	11	0	0.964	1.000	1.000
459	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(35), HSD17B2(13), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(15), HSD3B2(14)	3418004	96	60	90	38	68	6	6	4	12	0	0.0211	1.000	1.000
460	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(7), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(4), LMNA(5), LMNB1(2), LMNB2(4), PRF1(14)	8328136	93	59	92	48	51	11	7	14	10	0	0.641	1.000	1.000
461	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(6), KLK2(5), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), NGFR(8), RAF1(12)	3471788	73	59	62	32	38	8	3	13	11	0	0.0907	1.000	1.000
462	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(5), ACADM(5), ACADS(6), ACADVL(1), ACSL1(9), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(2), EHHADH(6), HADHA(6), PECR(2), SCP2(4), SLC25A20(1)	7229827	74	59	70	36	47	4	3	8	12	0	0.563	1.000	1.000
463	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CDK2(1), CDK4(8), CHEK1(2), MYT1(21), RB1(10), WEE1(2)	7143279	77	59	71	31	40	5	3	16	11	2	0.405	1.000	1.000
464	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(12), RBL2(6), SHC1(2), SOS1(10)	8413700	76	59	75	49	39	9	3	19	6	0	0.961	1.000	1.000
465	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(15), E2F1(6), MDM2(4), MYC(5), PIK3CA(10), PIK3R1(4), POLR1A(13), POLR1B(9), POLR1C(1), RB1(10), TBX2(6), TWIST1(1)	7857531	84	58	82	34	48	9	3	11	10	3	0.185	1.000	1.000
466	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26)	7138206	70	58	69	38	39	9	2	13	7	0	0.556	1.000	1.000
467	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6(2), IL6R(3), JAK1(7), JAK2(8), JAK3(11), PIAS3(6), PTPRU(23), REG1A(8), SRC(2), STAT3(11)	6479384	85	58	84	55	48	10	3	10	14	0	0.772	1.000	1.000
468	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(12), CYP11A1(14), CYP11B2(12), CYP17A1(7), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	2941950	90	57	85	58	66	9	1	5	9	0	0.0645	1.000	1.000
469	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(40), CYP2C9(41)	862439	81	57	73	58	61	5	2	2	11	0	0.830	1.000	1.000
470	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(26), HADHA(6), HSD17B12(4), PECR(2), SCD(4)	6109332	78	57	78	37	48	7	4	8	11	0	0.0492	1.000	1.000
471	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), HLA-DRA(13), HLA-DRB1(5), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(7), IL4(1), IL4R(18)	5100323	111	57	106	45	84	5	0	7	15	0	0.0308	1.000	1.000
472	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(9), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(18), NFATC2(12), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	5161279	88	56	84	56	57	9	3	5	14	0	0.607	1.000	1.000
473	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(7), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2)	6426475	77	56	75	41	46	10	1	13	7	0	0.428	1.000	1.000
474	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(9), IL22(2), IL22RA1(13), IL22RA2(3), JAK1(7), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), TYK2(9)	7778061	87	56	87	57	50	7	6	15	9	0	0.848	1.000	1.000
475	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(22), EGFR(26), ERBB3(7), NRG1(23), UBE2D1(1)	4414469	79	55	79	51	54	4	3	8	9	1	0.955	1.000	1.000
476	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(7), JAK2(8), JAK3(11), PIAS1(7), PIAS3(6), PTPRU(23), REG1A(8), SOAT1(3)	5825301	77	55	76	35	47	9	2	6	13	0	0.167	1.000	1.000
477	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(22), EGFR(26), HGS(5), RAB5A(2), TF(16), TFRC(4)	5473784	78	54	78	50	52	5	5	6	10	0	0.904	1.000	1.000
478	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), GCNT2(7), ST3GAL6(4), ST8SIA1(1)	6530877	74	54	72	46	40	12	5	7	9	1	0.600	1.000	1.000
479	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(4), BCAR1(5), CDKN1B(2), GRB2(2), ILK(2), ITGB1(7), MAPK1(4), MAPK3(3), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PTK2(7), SHC1(2), SOS1(10)	7844630	71	54	69	41	36	10	5	15	4	1	0.927	1.000	1.000
480	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(24), EP300(19), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	9521393	82	54	82	39	45	10	6	13	8	0	0.483	1.000	1.000
481	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(33), GNB1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9)	4059172	74	53	70	41	52	8	3	6	5	0	0.726	1.000	1.000
482	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(2), GCK(16), GFPT1(6), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), PGM3(1), RENBP(3), UAP1(2)	7242946	79	53	76	55	51	5	2	12	9	0	0.915	1.000	1.000
483	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(5), CD3D(7), CD3E(2), CD3G(1), GZMB(4), HLA-A(4), ICAM1(2), ITGAL(27), ITGB2(17), PRF1(14)	3717659	83	53	82	38	48	8	3	5	18	1	0.0550	1.000	1.000
484	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(12), ACYP1(1), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(7), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1)	11127647	77	53	76	47	42	11	6	12	6	0	0.906	1.000	1.000
485	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(7), BCL2(3), CASP3(3), CASP9(2), CYCS(1), DAXX(10), FAS(5), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1)	4856088	69	53	67	37	43	7	3	7	9	0	0.461	1.000	1.000
486	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(1), GRB2(2), HRAS(6), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), SHC1(2), SOS1(10)	6637650	78	53	76	43	44	10	3	11	9	1	0.802	1.000	1.000
487	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), PSMA7(1), WASF1(5), WASF2(6), WASF3(14), WASL(4)	6348133	72	52	71	38	44	7	4	9	8	0	0.818	1.000	1.000
488	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), CHST1(11), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	5319249	73	52	72	49	47	15	3	4	4	0	0.551	1.000	1.000
489	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(3), CCR3(11), CD4(9), HLA-DRA(13), HLA-DRB1(5), IL1B(8), IL4(1), IL5(4), IL5RA(17), IL6(2)	2279822	73	52	67	38	55	0	1	6	11	0	0.0595	1.000	1.000
490	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), WASL(4)	5555636	70	51	69	26	45	4	3	11	6	1	0.219	1.000	1.000
491	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(16), AMT(1), ATIC(5), DHFR(1), FTCD(4), GART(10), MTFMT(2), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2)	8079674	77	51	75	44	52	6	3	8	8	0	0.615	1.000	1.000
492	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1D(3), CSNK1E(5), NPAS2(6), NR1D1(1), PER1(8), PER2(12), PER3(12)	7252975	73	51	69	51	49	7	1	6	10	0	0.946	1.000	1.000
493	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(9), CHAT(20), CHKA(2), PCYT1A(3), PDHA1(5), PDHA2(20), PEMT(3), SLC18A3(2)	2931222	64	50	60	33	45	7	2	3	6	1	0.164	1.000	1.000
494	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(4), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(2), SIRT1(2), SIRT2(1), SIRT5(6), SIRT7(3), VNN2(17)	5055319	61	50	59	19	38	8	4	7	4	0	0.0392	1.000	1.000
495	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(10), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(12), JUND(1), MYOG(3), NR4A3(10), WDR1(6)	4534195	64	50	59	31	42	5	2	5	10	0	0.462	1.000	1.000
496	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(12), HDAC9(45), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1)	3182933	80	50	70	39	64	6	2	3	5	0	0.209	1.000	1.000
497	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(24), EP300(19), ESR1(6), MAPK1(4), MAPK3(3), PELP1(14), SRC(2)	6263992	72	50	71	37	44	7	5	11	5	0	0.639	1.000	1.000
498	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK14(5), MAPK8(3), NFKB1(6), RELA(4), TNFRSF13B(11), TNFRSF17(7), TNFSF13B(3), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	6134800	60	50	59	26	42	6	0	8	4	0	0.239	1.000	1.000
499	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(7), ARHGAP5(13), ARHGDIB(4), CASP1(4), CASP10(10), CASP3(3), CASP8(9), CASP9(2), CYCS(1), GZMB(4), JUN(1), PRF1(14)	5517335	72	49	70	35	46	5	3	13	5	0	0.608	1.000	1.000
500	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(5), AFMID(2), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2)	5716791	66	49	62	39	36	5	4	7	14	0	0.633	1.000	1.000
501	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(18), IRS1(5), JAK1(7), JAK3(11), RPS6KB1(4), SHC1(2), STAT6(9)	6294755	66	49	65	32	37	10	4	8	7	0	0.278	1.000	1.000
502	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(16), AMT(1), ATIC(5), ATP6V0C(3), DHFR(1), GART(10), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2)	7629387	74	49	72	37	49	6	4	8	7	0	0.337	1.000	1.000
503	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(5), ENO3(4), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3)	3561109	67	49	64	34	44	6	2	7	8	0	0.132	1.000	1.000
504	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(10), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(15), PON2(3), PON3(6), RDH11(3), RDH12(2), RDH13(3), RDH14(1)	3856527	72	48	71	35	52	4	2	7	7	0	0.116	1.000	1.000
505	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(5), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5)	9515594	57	48	57	49	36	6	1	6	8	0	0.994	1.000	1.000
506	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(3), OPRK1(23), POLR2A(14), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	5485395	70	47	69	67	51	3	4	5	7	0	0.997	1.000	1.000
507	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2)	5458276	64	47	60	35	35	5	3	7	14	0	0.514	1.000	1.000
508	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(29), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), KITLG(10)	2619952	74	47	66	33	53	3	2	8	8	0	0.0671	1.000	1.000
509	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(7), BAK1(2), BAX(5), BCL2(3), BIK(2), BIRC2(6), BIRC3(7), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(3)	5753598	58	47	57	21	29	6	7	6	10	0	0.228	1.000	1.000
510	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(6), JAK1(7), PTPRU(23), REG1A(8), STAT1(5), STAT2(6), TYK2(9)	5351023	67	47	66	37	38	8	1	8	12	0	0.347	1.000	1.000
511	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2)	5870983	58	46	56	27	38	4	2	8	6	0	0.563	1.000	1.000
512	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(14), CDO1(6), CSAD(7), GAD1(14), GAD2(9), GGT1(8)	2421221	58	46	55	36	36	8	4	5	5	0	0.626	1.000	1.000
513	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(7), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2)	5990805	66	46	64	34	38	8	3	11	6	0	0.467	1.000	1.000
514	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(11), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4)	5348314	53	45	52	27	24	6	6	5	12	0	0.652	1.000	1.000
515	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(7), CHST12(7), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(3), SULT1E1(16), SULT2A1(9), SULT2B1(6), SUOX(4)	3896847	78	45	75	43	57	6	0	6	9	0	0.321	1.000	1.000
516	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(2), BNIP1(4), GOSR1(2), GOSR2(3), SNAP25(9), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(2), STX3(2), STX4(1), STX5(4), STX6(2), TSNARE1(5), USE1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP7(8), VAMP8(1), VTI1A(1), VTI1B(1)	7070200	63	45	61	32	38	4	2	9	10	0	0.305	1.000	1.000
517	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(1), IL10(2), IL10RA(9), IL10RB(7), IL1A(5), IL6(2), JAK1(7), STAT1(5), STAT3(11), STAT5A(3), TNF(1)	5208279	56	45	55	36	30	4	5	8	9	0	0.663	1.000	1.000
518	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(3), ME1(22), PC(14), PDHA1(5), SLC25A11(4)	3974326	62	45	60	30	39	6	2	10	4	1	0.180	1.000	1.000
519	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(6), IFNAR1(3), IFNAR2(11), IFNB1(6), MAPK8(3), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4)	4723058	55	45	54	29	37	3	1	8	6	0	0.655	1.000	1.000
520	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(4), HMGB2(2), NME1(1), PRF1(14), SET(3)	4524146	68	45	66	27	37	6	6	11	8	0	0.224	1.000	1.000
521	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL15(4), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL9(1), LTA(5), TNF(1)	4210761	67	44	65	42	45	3	2	4	13	0	0.369	1.000	1.000
522	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(25), CKM(3), GPT(4), LDHA(6), LDHB(2), LDHC(7), MAPK14(5), NCL(6)	3838812	58	44	55	29	39	7	6	3	3	0	0.332	1.000	1.000
523	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(4), IFNGR1(4), JAK1(7), JAK2(8), PLA2G2A(2), PTPRU(23), REG1A(8), STAT1(5)	4868210	65	44	64	28	37	6	1	6	15	0	0.173	1.000	1.000
524	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), IMPA2(5), ISYNA1(1), PGM1(8), PGM3(1), TGDS(1)	4973149	66	43	64	45	46	5	2	7	6	0	0.664	1.000	1.000
525	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(19), MBTPS1(9), MBTPS2(3), SCAP(12), SREBF1(5), SREBF2(10)	5067953	60	43	57	30	40	3	3	10	4	0	0.299	1.000	1.000
526	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(9), CYP2E1(14), NR1I3(7), PTGS1(20), PTGS2(13)	2299063	63	42	61	37	47	5	0	2	9	0	0.255	1.000	1.000
527	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(7), BAD(4), BAK1(2), BAX(5), BCL10(3), BCL2(3), BCL2L11(8), CASP9(2), CES1(21)	4579626	55	42	52	23	39	6	3	3	4	0	0.331	1.000	1.000
528	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	13	A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(4), FUT2(4), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST8SIA1(1)	4292931	52	41	50	39	29	7	3	8	5	0	0.867	1.000	1.000
529	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(12), ACO1(8), ACO2(5), ACSS1(2), ACSS2(5), FH(3), IDH1(15), IDH2(2), MDH1(3), MDH2(4)	5708843	59	41	47	35	38	0	2	9	10	0	0.653	1.000	1.000
530	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(12), CAPN1(5), CAPNS1(3), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(5), CSNK1D(3), GSK3B(3), MAPT(10), PPP2CA(1)	3844516	50	41	48	24	30	4	2	7	7	0	0.335	1.000	1.000
531	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), PAPSS1(4), PAPSS2(5), SCLY(3), SEPHS1(2)	5313609	55	41	55	31	33	5	4	6	7	0	0.428	1.000	1.000
532	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9)	4464580	54	41	54	27	37	2	2	7	6	0	0.489	1.000	1.000
533	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9)	4464580	54	41	54	27	37	2	2	7	6	0	0.489	1.000	1.000
534	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(6), FOS(2), FYN(8), JUN(1), MAPK14(5), THBS1(31)	3160320	56	41	55	34	36	2	4	5	9	0	0.814	1.000	1.000
535	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5)	2736347	47	40	47	42	31	5	1	6	4	0	0.885	1.000	1.000
536	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5)	2736347	47	40	47	42	31	5	1	6	4	0	0.885	1.000	1.000
537	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(2), DHCR7(10), FDFT1(1), FDPS(3), GGCX(2), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SQLE(4), TM7SF2(5)	8219769	53	40	53	41	28	11	2	9	3	0	0.960	1.000	1.000
538	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4)	5721949	54	40	52	25	30	6	2	12	4	0	0.381	1.000	1.000
539	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), PGM1(8), PGM3(1), TGDS(1)	4367056	60	40	58	40	42	5	2	6	5	0	0.659	1.000	1.000
540	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(7), IL4(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), TOB1(3), TOB2(3)	4494803	61	40	61	31	46	3	1	1	10	0	0.259	1.000	1.000
541	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4)	7697587	41	39	41	33	25	6	1	4	5	0	0.979	1.000	1.000
542	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(4), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1)	6878598	48	39	47	24	26	6	2	10	4	0	0.630	1.000	1.000
543	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(9), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL9(1)	2580061	57	39	55	37	38	2	1	6	10	0	0.374	1.000	1.000
544	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(27), GNA12(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5)	4312019	53	38	53	33	33	4	1	9	6	0	0.846	1.000	1.000
545	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(16), GOT1(6), GOT2(6), TAT(21), TYR(11)	2008554	60	38	58	31	44	5	3	2	6	0	0.302	1.000	1.000
546	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(16), CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2)	3635220	49	38	49	20	28	2	4	7	6	2	0.248	1.000	1.000
547	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(9), CPS1(29), GLS(2), GLUD1(2), GOT1(6)	3274065	50	38	47	21	33	4	2	9	2	0	0.292	1.000	1.000
548	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), DHFR(1), FPGS(3), GGH(4), SPR(4)	2730835	53	37	49	27	37	5	4	1	6	0	0.0732	1.000	1.000
549	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	12	A4GALT(7), FUT1(4), FUT2(4), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	4025180	46	37	44	30	25	7	1	7	6	0	0.672	1.000	1.000
550	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(16), ATR(22), CDC25C(5), CHEK1(2), CHEK2(2)	6462961	47	37	46	26	33	3	2	5	4	0	0.890	1.000	1.000
551	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(7), JAK2(8), JAK3(11), MAPK1(4), MAPK3(3), STAT3(11), TYK2(9)	4971829	53	37	53	42	28	6	4	8	7	0	0.966	1.000	1.000
552	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(11), IFNB1(6), JAK1(7), STAT1(5), STAT2(6), TYK2(9)	4609311	48	36	48	24	30	3	2	8	5	0	0.410	1.000	1.000
553	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(9), AOC3(9), CES1(21), ESD(3)	2570858	42	35	39	25	32	2	1	3	4	0	0.548	1.000	1.000
554	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), LTB4R(1), P2RY1(5), P2RY2(10), P2RY6(2)	2546495	42	35	41	34	27	6	2	4	2	1	0.291	1.000	1.000
555	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(13), EIF2AK4(16), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF5(2), GSK3B(3), PPP1CA(3)	4952542	43	34	42	20	23	4	1	9	6	0	0.633	1.000	1.000
556	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), ACO2(5), FH(3), IDH1(15), IDH2(2), MDH1(3), MDH2(4)	3829553	40	34	28	20	26	0	2	5	7	0	0.460	1.000	1.000
557	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(4), NRF1(7), TAX1BP3(1), UBE2A(1), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(3), UBE2J1(2), UBE2J2(8), UBE2L3(1), UBE2L6(2), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(6)	4513798	47	34	45	23	33	4	2	4	4	0	0.550	1.000	1.000
558	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), FBXW7(11), RB1(10), TFDP1(2)	3483175	41	33	40	17	18	2	5	5	9	2	0.395	1.000	1.000
559	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(3), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(5), PPT2(1)	3623871	38	33	38	16	23	4	4	3	4	0	0.312	1.000	1.000
560	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(15), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(4), FUT2(4), FUT3(8), ST3GAL3(3), ST3GAL4(1)	3064649	39	33	37	25	25	6	2	2	4	0	0.574	1.000	1.000
561	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(4), RPN2(4), UBE2A(1), UBE3A(6)	5529517	41	33	41	22	24	5	2	7	3	0	0.664	1.000	1.000
562	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(2), ALAS2(6), CPO(5), FECH(3), GATA1(4), HBA1(1), HBB(8), HMBS(1), UROS(1)	3298723	36	32	35	20	27	2	0	2	5	0	0.382	1.000	1.000
563	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(3), PGK1(3), PKLR(14), TPI1(1)	3925043	45	32	42	28	29	4	1	5	6	0	0.322	1.000	1.000
564	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(5), ESR1(6), GREB1(23), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(5)	4570886	50	32	49	28	35	4	4	3	4	0	0.312	1.000	1.000
565	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	BFAR(2), CAMP(2), CREB3(1), CREB5(9), MAPK1(4), RAF1(12), SNX13(5), SRC(2), TERF2IP(2)	4123067	39	32	37	29	28	3	1	4	3	0	0.935	1.000	1.000
566	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1E(5), PER1(8)	3605154	39	31	38	23	26	5	1	3	4	0	0.801	1.000	1.000
567	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2)	7104319	40	31	40	27	24	3	4	6	3	0	0.950	1.000	1.000
568	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), ADSS(2), DHFR(1), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(8), PRPS2(3), RRM1(3), SRM(1)	5315371	38	31	38	36	22	2	2	5	7	0	0.995	1.000	1.000
569	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(9), CD80(4), HLA-DRA(13), HLA-DRB1(5), IL10(2), IL2(4), IL4(1)	1685448	40	30	38	22	28	0	0	6	5	1	0.230	1.000	1.000
570	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), HMGCS1(2), IDI1(1), LSS(4), MVD(1), MVK(2), NSDHL(3), PMVK(2), SQLE(4)	5613075	38	30	38	28	19	8	1	8	2	0	0.958	1.000	1.000
571	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(3), CASP7(4), DFFA(2), DFFB(2), GZMB(4), HMGB1(1), HMGB2(2), TOP2A(11), TOP2B(9)	3787166	38	30	37	12	25	2	5	2	4	0	0.216	1.000	1.000
572	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(9), PTPRA(9), SRC(2)	3961867	40	30	39	27	28	4	1	3	4	0	0.785	1.000	1.000
573	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(6), PTK2B(12), SHC1(2), SOS1(10), SRC(2)	3758030	34	29	34	31	22	3	0	6	3	0	0.997	1.000	1.000
574	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(10), PLCG1(9), PRKCA(9), PTK2B(12)	2884962	40	29	38	35	31	3	1	2	3	0	0.825	1.000	1.000
575	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	3358600	35	29	35	21	20	7	2	3	3	0	0.649	1.000	1.000
576	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(3), CSF1(12), IL1B(8), MST1(2), MST1R(10), TNF(1)	2797568	36	29	35	33	25	5	1	2	3	0	0.968	1.000	1.000
577	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDK2(1), CDKN1B(2), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2), UBE2M(1)	3665141	32	29	32	17	13	2	5	4	6	2	0.675	1.000	1.000
578	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	3515682	33	29	33	16	22	1	2	3	5	0	0.416	1.000	1.000
579	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), IDI1(1), LSS(4), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SQLE(4)	4698459	35	28	35	29	17	6	1	8	3	0	0.978	1.000	1.000
580	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), SDS(3)	3568463	32	27	31	20	21	4	1	2	4	0	0.797	1.000	1.000
581	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(4), OXCT2(5)	3051553	39	27	37	22	24	5	1	4	5	0	0.714	1.000	1.000
582	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(3), NFE2L2(4), PRKCA(9)	3783534	32	26	30	18	22	1	0	3	6	0	0.666	1.000	1.000
583	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(25), RANGAP1(3)	3635217	29	26	28	13	20	2	1	1	5	0	0.681	1.000	1.000
584	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(10), EPHX2(6), HSD3B7(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1)	2057178	30	25	30	19	19	2	3	3	3	0	0.555	1.000	1.000
585	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NFS1(4), TPK1(11)	2729917	27	25	27	14	17	1	2	2	5	0	0.766	1.000	1.000
586	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(29), PDXK(2), PNPO(1), PSAT1(4)	2078451	36	25	34	23	28	1	2	4	1	0	0.761	1.000	1.000
587	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB10(2), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4)	3756764	32	25	32	13	17	4	2	7	2	0	0.446	1.000	1.000
588	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(3), APOBEC2(5), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(3)	3153147	28	24	27	38	20	2	3	2	1	0	1.000	1.000	1.000
589	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3)	3720288	29	24	29	13	17	3	3	4	2	0	0.532	1.000	1.000
590	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST3GAL5(3), ST6GALNAC2(3), ST6GALNAC4(4), ST8SIA1(1)	2421539	23	23	23	13	14	3	2	3	1	0	0.470	1.000	1.000
591	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(4), IFNGR1(4), IFNGR2(4), JAK1(7), JAK2(8), STAT1(5)	3480656	32	23	30	13	15	1	1	5	10	0	0.626	1.000	1.000
592	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), IDH2(2), MDH1(3), OGDH(10), SDHA(4)	4043724	29	23	29	24	18	0	2	6	3	0	0.953	1.000	1.000
593	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(7), HADHA(6), SDS(3)	3331751	27	22	26	13	17	4	0	3	3	0	0.430	1.000	1.000
594	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(2), ALAS2(6), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1)	3228730	25	22	25	13	17	2	1	2	3	0	0.489	1.000	1.000
595	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(3), FURIN(7), NOTCH1(9), PSEN1(3)	3928050	23	22	23	21	12	4	2	4	1	0	0.941	1.000	1.000
596	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), WASF1(5), WASL(4)	3291311	29	22	29	12	17	4	2	4	2	0	0.420	1.000	1.000
597	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9)	1367799	31	22	30	23	22	2	0	3	4	0	0.631	1.000	1.000
598	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1)	2985660	22	21	22	13	13	1	1	6	1	0	0.865	1.000	1.000
599	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(8), BMPR1A(2), BMPR1B(4), BMPR2(7)	2683733	21	20	21	11	10	4	2	3	2	0	0.642	1.000	1.000
600	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(4), ECHS1(3), EHHADH(6), HADHA(6), SDS(3)	2066224	22	19	20	11	14	3	0	3	2	0	0.443	1.000	1.000
601	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(6), GBA(7), GGT1(8), SHMT1(2), SHMT2(3)	2292319	26	18	25	15	19	3	0	3	1	0	0.432	1.000	1.000
602	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), DNAJC3(3), EIF2S1(1), NFKB1(6), NFKBIA(2), RELA(4)	3782875	18	18	18	9	10	3	1	2	2	0	0.595	1.000	1.000
603	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(3), FUT1(4), FUT2(4), GCNT2(7), ST8SIA1(1)	2274686	19	17	19	13	11	2	2	3	1	0	0.738	1.000	1.000
604	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(1), HGD(15)	956700	20	17	20	19	13	3	2	0	2	0	0.932	1.000	1.000
605	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(2), CBS(7), CTH(1), MUT(5)	2158481	16	16	16	10	11	2	1	1	1	0	0.703	1.000	1.000
606	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(3), KARS(4)	1992973	15	15	15	7	13	0	0	2	0	0	0.629	1.000	1.000
607	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(2), RAB5A(2)	1797950	17	15	16	12	13	2	0	1	1	0	0.792	1.000	1.000
608	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2)	2324817	18	14	18	17	5	5	3	3	2	0	0.987	1.000	1.000
609	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(3), GGT1(8), SHMT1(2), SHMT2(3)	1737524	16	13	16	13	11	2	1	2	0	0	0.765	1.000	1.000
610	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(20)	780976	21	13	20	15	15	2	1	2	1	0	0.772	1.000	1.000
611	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4)	1253962	22	13	21	10	14	2	0	1	5	0	0.317	1.000	1.000
612	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(6)	2099109	11	11	11	11	5	0	1	0	5	0	0.979	1.000	1.000
613	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(7)	1320714	11	11	11	11	7	0	1	2	1	0	0.936	1.000	1.000
614	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4)	1813037	11	11	11	7	6	1	1	3	0	0	0.769	1.000	1.000
615	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(6)	1645771	10	10	10	10	4	0	1	0	5	0	0.973	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5)	909034	5	5	5	5	5	0	0	0	0	0	0.858	1.000	1.000
