GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in ACC-TP

Adrenocortical Carcinoma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in ACC-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1WD3ZHQ

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 192
Number of samples: 79
Original number of Gene Sets: 404
Maximum gene set size: 388

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 4 :[ clus1 ] 24
pheno.type: 2 - 4 :[ clus2 ] 14
pheno.type: 3 - 4 :[ clus3 ] 18
pheno.type: 4 - 4 :[ clus4 ] 23

For the expression subtypes of 17733 genes in 80 samples, GSEA found enriched gene sets in each cluster using 79 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are BIOCARTA G1 PATHWAY, BIOCARTA MPR PATHWAY, KEGG PYRIMIDINE METABOLISM, KEGG LYSINE DEGRADATION, KEGG SELENOAMINO ACID METABOLISM, KEGG PYRUVATE METABOLISM, KEGG RIBOSOME, KEGG RNA DEGRADATION, KEGG RNA POLYMERASE, KEGG DNA REPLICATION

And common core enriched genes are IFNG, POMP, PSMA1, PSMA3, PSMA4, PSMA5, PSMA6, PSMA8, PSMB1, PSMB11

clus2

Top enriched gene sets are BIOCARTA NO1 PATHWAY, BIOCARTA AGR PATHWAY, BIOCARTA ALK PATHWAY, BIOCARTA VIP PATHWAY, BIOCARTA CHREBP2 PATHWAY, BIOCARTA WNT PATHWAY, KEGG CYSTEINE AND METHIONINE METABOLISM, KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE, KEGG MAPK SIGNALING PATHWAY, KEGG WNT SIGNALING PATHWAY

And common core enriched genes are CTNNB1, LEF1, BMP4, APC, BTRC, CCND1, CREBBP, CSNK1A1, FRAT1, FZD1

clus3

Top enriched gene sets are BIOCARTA AT1R PATHWAY, BIOCARTA EGF PATHWAY, BIOCARTA GH PATHWAY, BIOCARTA PYK2 PATHWAY, BIOCARTA CHREBP2 PATHWAY, BIOCARTA CREB PATHWAY, KEGG PENTOSE PHOSPHATE PATHWAY, KEGG STEROID HORMONE BIOSYNTHESIS, KEGG O GLYCAN BIOSYNTHESIS, KEGG BUTANOATE METABOLISM

And common core enriched genes are CUL4A, CUL4B, ERCC8, CCNH, CDK7, ERCC2, ERCC4, ERCC5, GTF2H2, GTF2H3

clus4

Top enriched gene sets are BIOCARTA BIOPEPTIDES PATHWAY, BIOCARTA CARM ER PATHWAY, BIOCARTA HDAC PATHWAY, BIOCARTA EGF PATHWAY, BIOCARTA FCER1 PATHWAY, BIOCARTA GH PATHWAY, BIOCARTA IL2RB PATHWAY, BIOCARTA GSK3 PATHWAY, BIOCARTA DEATH PATHWAY, BIOCARTA KERATINOCYTE PATHWAY

And common core enriched genes are PIK3CG, PIK3R1, PTPN6, STAT5A, NFATC2, BCL2, FAS, FASLG, IKZF3, IL2RA

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA G1 PATHWAY	27	genes.ES.table	0.49	1.4	0.18	0.64	0.95	0.48	0.3	0.34	0.52	0.19
BIOCARTA MPR PATHWAY	32	genes.ES.table	0.43	1.4	0.12	0.58	0.95	0.41	0.18	0.33	0.47	0.15
KEGG PYRIMIDINE METABOLISM	97	genes.ES.table	0.28	1.2	0.23	0.89	1	0.26	0.16	0.22	0.78	0.35
KEGG LYSINE DEGRADATION	42	genes.ES.table	0.22	0.98	0.44	1	1	0.17	0.12	0.15	1	0.66
KEGG SELENOAMINO ACID METABOLISM	25	genes.ES.table	0.38	1.2	0.26	0.84	1	0.28	0.13	0.24	0.74	0.3
KEGG PYRUVATE METABOLISM	37	genes.ES.table	0.31	0.98	0.47	1	1	0.24	0.17	0.2	1	0.71
KEGG RIBOSOME	84	genes.ES.table	0.57	1.6	0.075	0.41	0.68	0.73	0.29	0.52	0.26	0.11
KEGG RNA DEGRADATION	56	genes.ES.table	0.29	1.4	0.12	0.5	0.9	0.38	0.26	0.28	0.38	0.11
KEGG RNA POLYMERASE	28	genes.ES.table	0.31	1.2	0.26	0.9	1	0.46	0.28	0.34	0.79	0.36
KEGG DNA REPLICATION	35	genes.ES.table	0.57	1.5	0.14	0.53	0.87	0.54	0.22	0.42	0.4	0.14

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PSME4	PSME4	PSME4	1376	0.22	-0.01	YES
2	PSMD4	PSMD4	PSMD4	1650	0.2	0.034	YES
3	PSMB9	PSMB9	PSMB9	1983	0.18	0.068	YES
4	PSMD13	PSMD13	PSMD13	2328	0.16	0.095	YES
5	PSMC3	PSMC3	PSMC3	2489	0.15	0.13	YES
6	PSMD1	PSMD1	PSMD1	2660	0.14	0.16	YES
7	PSMA8	PSMA8	PSMA8	2734	0.14	0.2	YES
8	PSMB4	PSMB4	PSMB4	2757	0.13	0.24	YES
9	PSMD14	PSMD14	PSMD14	2916	0.13	0.27	YES
10	PSMC1	PSMC1	PSMC1	3248	0.12	0.28	YES
11	PSMC5	PSMC5	PSMC5	3270	0.11	0.32	YES
12	PSMA4	PSMA4	PSMA4	3457	0.11	0.34	YES
13	PSME2	PSME2	PSME2	3463	0.11	0.37	YES
14	PSMD11	PSMD11	PSMD11	3532	0.1	0.4	YES
15	PSMA1	PSMA1	PSMA1	3842	0.095	0.41	YES
16	PSMB5	PSMB5	PSMB5	3913	0.092	0.43	YES
17	PSMB3	PSMB3	PSMB3	4061	0.088	0.45	YES
18	PSMA5	PSMA5	PSMA5	4206	0.084	0.47	YES
19	PSMD2	PSMD2	PSMD2	4300	0.081	0.49	YES
20	PSMB11	PSMB11	PSMB11	4623	0.072	0.49	YES
21	PSMD12	PSMD12	PSMD12	4875	0.065	0.5	YES
22	PSMB7	PSMB7	PSMB7	5071	0.06	0.5	YES
23	POMP	POMP	POMP	5259	0.056	0.51	YES
24	PSMA6	PSMA6	PSMA6	5425	0.052	0.52	YES
25	PSMC6	PSMC6	PSMC6	5427	0.052	0.53	YES
26	PSMB1	PSMB1	PSMB1	5759	0.043	0.52	YES
27	PSMA3	PSMA3	PSMA3	5824	0.041	0.53	YES
28	PSME3	PSME3	PSME3	6028	0.036	0.53	YES
29	PSMD3	PSMD3	PSMD3	6039	0.036	0.54	YES
30	PSMC4	PSMC4	PSMC4	6156	0.034	0.55	YES
31	PSMD6	PSMD6	PSMD6	6170	0.033	0.56	YES
32	PSME1	PSME1	PSME1	6256	0.031	0.56	YES
33	IFNG	IFNG	IFNG	6322	0.029	0.57	YES
34	PSMB6	PSMB6	PSMB6	6329	0.029	0.57	YES
35	PSMB2	PSMB2	PSMB2	6872	0.017	0.55	NO
36	PSMA7	PSMA7	PSMA7	7461	0.0041	0.52	NO
37	PSMA2	PSMA2	PSMA2	7554	0.0021	0.51	NO
38	PSMF1	PSMF1	PSMF1	8465	-0.018	0.47	NO
39	PSMB8	PSMB8	PSMB8	8609	-0.021	0.46	NO
40	PSMD7	PSMD7	PSMD7	8689	-0.023	0.47	NO
41	PSMD8	PSMD8	PSMD8	8968	-0.029	0.46	NO
42	PSMC2	PSMC2	PSMC2	9757	-0.049	0.43	NO
43	SHFM1	SHFM1	SHFM1	10522	-0.068	0.41	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLE2	POLE2	POLE2	347	0.41	0.089	YES
2	NEIL1	NEIL1	NEIL1	613	0.33	0.16	YES
3	FEN1	FEN1	FEN1	687	0.32	0.24	YES
4	NEIL3	NEIL3	NEIL3	734	0.31	0.32	YES
5	POLE4	POLE4	POLE4	1451	0.22	0.34	YES
6	MUTYH	MUTYH	MUTYH	2039	0.17	0.35	YES
7	POLD3	POLD3	POLD3	2402	0.15	0.37	YES
8	POLD1	POLD1	POLD1	2471	0.15	0.41	YES
9	PARP1	PARP1	PARP1	2762	0.13	0.43	YES
10	NTHL1	NTHL1	NTHL1	2871	0.13	0.46	YES
11	POLD2	POLD2	POLD2	3619	0.1	0.44	YES
12	PARP2	PARP2	PARP2	3869	0.094	0.45	YES
13	OGG1	OGG1	OGG1	4185	0.085	0.46	YES
14	POLB	POLB	POLB	4561	0.073	0.45	YES
15	APEX1	APEX1	APEX1	4621	0.072	0.47	YES
16	TDG	TDG	TDG	4741	0.069	0.48	YES
17	LIG1	LIG1	LIG1	5040	0.061	0.48	YES
18	POLE3	POLE3	POLE3	5258	0.056	0.48	YES
19	PCNA	PCNA	PCNA	6243	0.032	0.44	NO
20	POLD4	POLD4	POLD4	6406	0.027	0.43	NO
21	MPG	MPG	MPG	6529	0.024	0.43	NO
22	POLE	POLE	POLE	6826	0.018	0.42	NO
23	SMUG1	SMUG1	SMUG1	7820	-0.004	0.37	NO
24	MBD4	MBD4	MBD4	8024	-0.0082	0.36	NO
25	POLL	POLL	POLL	8394	-0.017	0.34	NO
26	XRCC1	XRCC1	XRCC1	9523	-0.043	0.29	NO
27	UNG	UNG	UNG	9915	-0.053	0.28	NO
28	LIG3	LIG3	LIG3	10004	-0.055	0.29	NO
29	NEIL2	NEIL2	NEIL2	10762	-0.074	0.27	NO
30	PARP3	PARP3	PARP3	10782	-0.074	0.28	NO
31	PARP4	PARP4	PARP4	11490	-0.093	0.27	NO
32	APEX2	APEX2	APEX2	15978	-0.31	0.098	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPL21	RPL21	RPL21	446	0.38	0.022	YES
2	RPS27A	RPS27A	RPS27A	1532	0.21	-0.014	YES
3	RPS7	RPS7	RPS7	1694	0.2	0.0018	YES
4	RPL37A	RPL37A	RPL37A	1726	0.19	0.024	YES
5	RPL27A	RPL27A	RPL27A	1760	0.19	0.046	YES
6	RPL27	RPL27	RPL27	1891	0.18	0.061	YES
7	RPL23A	RPL23A	RPL23A	2104	0.17	0.07	YES
8	RPS3	RPS3	RPS3	2214	0.16	0.084	YES
9	RPL31	RPL31	RPL31	2312	0.16	0.098	YES
10	RPS25	RPS25	RPS25	2368	0.15	0.11	YES
11	RPS18	RPS18	RPS18	2411	0.15	0.13	YES
12	RPL17	RPL17	RPL17	2456	0.15	0.15	YES
13	RPLP2	RPLP2	RPLP2	2540	0.14	0.16	YES
14	RPS29	RPS29	RPS29	2715	0.14	0.17	YES
15	RPSA	RPSA	RPSA	2849	0.13	0.18	YES
16	RPS13	RPS13	RPS13	2859	0.13	0.19	YES
17	RPS19	RPS19	RPS19	2868	0.13	0.21	YES
18	RPS12	RPS12	RPS12	2925	0.13	0.22	YES
19	RPS24	RPS24	RPS24	2954	0.13	0.23	YES
20	RPL36	RPL36	RPL36	2974	0.12	0.25	YES
21	RPLP1	RPLP1	RPLP1	2990	0.12	0.26	YES
22	RPS17	RPS17	RPS17	3027	0.12	0.28	YES
23	FAU	FAU	FAU	3183	0.12	0.28	YES
24	RPL29	RPL29	RPL29	3247	0.12	0.29	YES
25	RPL22	RPL22	RPL22	3374	0.11	0.3	YES
26	RPS8	RPS8	RPS8	3415	0.11	0.31	YES
27	RPL18A	RPL18A	RPL18A	3454	0.11	0.32	YES
28	RPL4	RPL4	RPL4	3459	0.11	0.34	YES
29	RPL35	RPL35	RPL35	3533	0.1	0.34	YES
30	RPS10	RPS10	RPS10	3548	0.1	0.36	YES
31	RPL32	RPL32	RPL32	3653	0.1	0.36	YES
32	RPS9	RPS9	RPS9	3655	0.1	0.38	YES
33	RPLP0	RPLP0	RPLP0	3724	0.099	0.38	YES
34	RPL11	RPL11	RPL11	3795	0.096	0.39	YES
35	RPS2	RPS2	RPS2	3875	0.094	0.4	YES
36	RPL22L1	RPL22L1	RPL22L1	3924	0.092	0.41	YES
37	RPL14	RPL14	RPL14	3983	0.091	0.42	YES
38	RPL35A	RPL35A	RPL35A	3987	0.091	0.43	YES
39	RPL13A	RPL13A	RPL13A	4140	0.086	0.43	YES
40	RPS27	RPS27	RPS27	4182	0.085	0.44	YES
41	RPL23	RPL23	RPL23	4220	0.084	0.44	YES
42	RPL8	RPL8	RPL8	4290	0.082	0.45	YES
43	RPL30	RPL30	RPL30	4293	0.082	0.46	YES
44	RPS20	RPS20	RPS20	4315	0.081	0.47	YES
45	RPS16	RPS16	RPS16	4332	0.08	0.48	YES
46	RPL12	RPL12	RPL12	4379	0.079	0.49	YES
47	RPL26	RPL26	RPL26	4544	0.074	0.49	YES
48	RPL19	RPL19	RPL19	4565	0.073	0.5	YES
49	RPS11	RPS11	RPS11	4597	0.072	0.5	YES
50	UBA52	UBA52	UBA52	4612	0.072	0.51	YES
51	RPL5	RPL5	RPL5	4634	0.072	0.52	YES
52	RPL24	RPL24	RPL24	4668	0.071	0.52	YES
53	RPS26	RPS26	RPS26	4736	0.069	0.53	YES
54	RPL3	RPL3	RPL3	4831	0.066	0.53	YES
55	RPS15	RPS15	RPS15	4845	0.066	0.54	YES
56	RPL28	RPL28	RPL28	4862	0.066	0.55	YES
57	RPL10A	RPL10A	RPL10A	4930	0.064	0.55	YES
58	RPL38	RPL38	RPL38	4979	0.062	0.56	YES
59	RPL7	RPL7	RPL7	5008	0.062	0.56	YES
60	RPL36AL	RPL36AL	RPL36AL	5086	0.06	0.57	YES
61	RPL7A	RPL7A	RPL7A	5145	0.059	0.57	YES
62	RPS3A	RPS3A	RPS3A	5454	0.051	0.56	NO
63	RPS15A	RPS15A	RPS15A	5465	0.051	0.56	NO
64	RPL13	RPL13	RPL13	5603	0.047	0.56	NO
65	RPL15	RPL15	RPL15	5625	0.046	0.57	NO
66	RPS5	RPS5	RPS5	5701	0.044	0.57	NO
67	RPL41	RPL41	RPL41	5783	0.042	0.57	NO
68	RPS21	RPS21	RPS21	6403	0.027	0.54	NO
69	RPS6	RPS6	RPS6	6663	0.022	0.52	NO
70	RPL37	RPL37	RPL37	6817	0.018	0.52	NO
71	MRPL13	MRPL13	MRPL13	6880	0.017	0.52	NO
72	RPL39	RPL39	RPL39	7139	0.011	0.5	NO
73	RPL6	RPL6	RPL6	7234	0.0091	0.5	NO
74	RSL24D1	RSL24D1	RSL24D1	7518	0.003	0.48	NO
75	RPS4X	RPS4X	RPS4X	7716	-0.0016	0.47	NO
76	RPL34	RPL34	RPL34	8102	-0.01	0.45	NO
77	RPL10	RPL10	RPL10	8258	-0.014	0.45	NO
78	RPS27L	RPS27L	RPS27L	8532	-0.02	0.43	NO
79	RPS23	RPS23	RPS23	8692	-0.023	0.43	NO
80	RPS28	RPS28	RPS28	10647	-0.071	0.32	NO
81	RPL26L1	RPL26L1	RPL26L1	10697	-0.072	0.33	NO
82	RPS4Y1	RPS4Y1	RPS4Y1	11213	-0.085	0.31	NO
83	RPL9	RPL9	RPL9	13932	-0.18	0.18	NO
84	RPL36A	RPL36A	RPL36A	15622	-0.28	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDC20	CDC20	CDC20	83	0.57	0.026	YES
2	CDC25A	CDC25A	CDC25A	109	0.54	0.054	YES
3	BUB1	BUB1	BUB1	128	0.53	0.082	YES
4	CDC45	CDC45	CDC45	130	0.52	0.11	YES
5	E2F2	E2F2	E2F2	135	0.52	0.14	YES
6	ORC1L	ORC1L	ORC1L	263	0.44	0.16	YES
7	PLK1	PLK1	PLK1	285	0.43	0.18	YES
8	CCNB2	CCNB2	CCNB2	298	0.42	0.2	YES
9	BUB1B	BUB1B	BUB1B	351	0.4	0.22	YES
10	CDK1	CDK1	CDK1	365	0.4	0.24	YES
11	CDC7	CDC7	CDC7	469	0.37	0.25	YES
12	PTTG1	PTTG1	PTTG1	470	0.37	0.27	YES
13	CCNA2	CCNA2	CCNA2	505	0.36	0.29	YES
14	PKMYT1	PKMYT1	PKMYT1	590	0.34	0.3	YES
15	CDC25C	CDC25C	CDC25C	751	0.31	0.31	YES
16	CCNE2	CCNE2	CCNE2	779	0.3	0.33	YES
17	TTK	TTK	TTK	781	0.3	0.34	YES
18	CHEK2	CHEK2	CHEK2	920	0.28	0.35	YES
19	CHEK1	CHEK1	CHEK1	959	0.28	0.36	YES
20	ESPL1	ESPL1	ESPL1	997	0.27	0.38	YES
21	CDC6	CDC6	CDC6	1019	0.27	0.39	YES
22	CDK6	CDK6	CDK6	1021	0.27	0.4	YES
23	MCM6	MCM6	MCM6	1046	0.26	0.42	YES
24	MYC	MYC	MYC	1117	0.25	0.43	YES
25	MCM2	MCM2	MCM2	1182	0.25	0.44	YES
26	TGFB2	TGFB2	TGFB2	1233	0.24	0.45	YES
27	MCM5	MCM5	MCM5	1270	0.24	0.46	YES
28	SFN	SFN	SFN	1288	0.23	0.47	YES
29	GADD45A	GADD45A	GADD45A	1476	0.21	0.47	YES
30	SKP2	SKP2	SKP2	1495	0.21	0.48	YES
31	CCNB1	CCNB1	CCNB1	1566	0.21	0.49	YES
32	MCM7	MCM7	MCM7	1634	0.2	0.5	YES
33	RBX1	RBX1	RBX1	2125	0.17	0.48	YES
34	ORC2L	ORC2L	ORC2L	2184	0.16	0.48	YES
35	SMC1B	SMC1B	SMC1B	2385	0.15	0.48	YES
36	YWHAH	YWHAH	YWHAH	2515	0.14	0.48	YES
37	CDKN2C	CDKN2C	CDKN2C	2643	0.14	0.48	YES
38	MCM4	MCM4	MCM4	2694	0.14	0.48	YES
39	MAD2L2	MAD2L2	MAD2L2	2780	0.13	0.49	YES
40	CCND1	CCND1	CCND1	2782	0.13	0.49	YES
41	ORC6L	ORC6L	ORC6L	3016	0.12	0.49	YES
42	SMAD3	SMAD3	SMAD3	3021	0.12	0.49	YES
43	SMAD2	SMAD2	SMAD2	3060	0.12	0.5	YES
44	ANAPC1	ANAPC1	ANAPC1	3099	0.12	0.5	YES
45	MCM3	MCM3	MCM3	3110	0.12	0.51	YES
46	MAD1L1	MAD1L1	MAD1L1	3189	0.12	0.51	YES
47	WEE1	WEE1	WEE1	3241	0.12	0.51	YES
48	CDC25B	CDC25B	CDC25B	3272	0.11	0.52	YES
49	BUB3	BUB3	BUB3	3379	0.11	0.52	YES
50	E2F1	E2F1	E2F1	3398	0.11	0.52	YES
51	ANAPC11	ANAPC11	ANAPC11	3430	0.11	0.53	YES
52	CDC26	CDC26	CDC26	3732	0.099	0.52	NO
53	HDAC2	HDAC2	HDAC2	3754	0.098	0.52	NO
54	ORC4L	ORC4L	ORC4L	3852	0.095	0.52	NO
55	YWHAQ	YWHAQ	YWHAQ	3877	0.094	0.52	NO
56	MAD2L1	MAD2L1	MAD2L1	4086	0.088	0.52	NO
57	CDKN1C	CDKN1C	CDKN1C	4343	0.08	0.5	NO
58	CDKN2A	CDKN2A	CDKN2A	4437	0.077	0.5	NO
59	TFDP1	TFDP1	TFDP1	4472	0.076	0.51	NO
60	SMAD4	SMAD4	SMAD4	4814	0.067	0.49	NO
61	TGFB3	TGFB3	TGFB3	5229	0.056	0.47	NO
62	PRKDC	PRKDC	PRKDC	5251	0.056	0.47	NO
63	CDK2	CDK2	CDK2	5385	0.053	0.47	NO
64	ZBTB17	ZBTB17	ZBTB17	5435	0.052	0.47	NO
65	CDKN2D	CDKN2D	CDKN2D	5463	0.051	0.47	NO
66	CCNE1	CCNE1	CCNE1	6213	0.032	0.43	NO
67	PCNA	PCNA	PCNA	6243	0.032	0.43	NO
68	CDKN1A	CDKN1A	CDKN1A	6292	0.03	0.43	NO
69	MDM2	MDM2	MDM2	6349	0.029	0.42	NO
70	CDC16	CDC16	CDC16	6455	0.026	0.42	NO
71	ANAPC7	ANAPC7	ANAPC7	6541	0.024	0.42	NO
72	TGFB1	TGFB1	TGFB1	6567	0.024	0.42	NO
73	ORC3L	ORC3L	ORC3L	6893	0.016	0.4	NO
74	SMC3	SMC3	SMC3	6983	0.014	0.4	NO
75	TFDP2	TFDP2	TFDP2	7109	0.012	0.39	NO
76	CDK4	CDK4	CDK4	7239	0.0089	0.38	NO
77	TP53	TP53	TP53	7338	0.0068	0.38	NO
78	YWHAZ	YWHAZ	YWHAZ	7370	0.0061	0.38	NO
79	YWHAE	YWHAE	YWHAE	7472	0.0038	0.37	NO
80	CDC27	CDC27	CDC27	7522	0.0029	0.37	NO
81	HDAC1	HDAC1	HDAC1	7532	0.0027	0.37	NO
82	PTTG2	PTTG2	PTTG2	7572	0.0017	0.36	NO
83	E2F5	E2F5	E2F5	7675	-0.0004	0.36	NO
84	E2F4	E2F4	E2F4	8061	-0.0093	0.34	NO
85	CCND3	CCND3	CCND3	8164	-0.012	0.33	NO
86	GSK3B	GSK3B	GSK3B	8169	-0.012	0.33	NO
87	ANAPC2	ANAPC2	ANAPC2	8293	-0.014	0.33	NO
88	ATM	ATM	ATM	8503	-0.019	0.32	NO
89	ABL1	ABL1	ABL1	8542	-0.02	0.31	NO
90	ANAPC5	ANAPC5	ANAPC5	8543	-0.02	0.32	NO
91	RAD21	RAD21	RAD21	8761	-0.024	0.3	NO
92	SMC1A	SMC1A	SMC1A	8816	-0.026	0.3	NO
93	ANAPC10	ANAPC10	ANAPC10	8944	-0.028	0.3	NO
94	FZR1	FZR1	FZR1	9079	-0.032	0.29	NO
95	CCNA1	CCNA1	CCNA1	9427	-0.041	0.27	NO
96	ATR	ATR	ATR	9603	-0.045	0.27	NO
97	CDC14A	CDC14A	CDC14A	9684	-0.047	0.26	NO
98	YWHAB	YWHAB	YWHAB	9778	-0.05	0.26	NO
99	EP300	EP300	EP300	9891	-0.052	0.26	NO
100	CCNB3	CCNB3	CCNB3	10017	-0.055	0.25	NO
101	ORC5L	ORC5L	ORC5L	10091	-0.057	0.25	NO
102	ANAPC13	ANAPC13	ANAPC13	10165	-0.059	0.25	NO
103	CUL1	CUL1	CUL1	10600	-0.07	0.23	NO
104	E2F3	E2F3	E2F3	10696	-0.072	0.23	NO
105	CDKN1B	CDKN1B	CDKN1B	10878	-0.077	0.22	NO
106	CDC23	CDC23	CDC23	11409	-0.091	0.2	NO
107	STAG1	STAG1	STAG1	11500	-0.093	0.2	NO
108	CCNH	CCNH	CCNH	12171	-0.11	0.17	NO
109	RB1	RB1	RB1	12214	-0.11	0.17	NO
110	YWHAG	YWHAG	YWHAG	12323	-0.12	0.17	NO
111	CDC14B	CDC14B	CDC14B	12362	-0.12	0.17	NO
112	SKP1	SKP1	SKP1	12508	-0.12	0.17	NO
113	GADD45B	GADD45B	GADD45B	12597	-0.13	0.18	NO
114	ANAPC4	ANAPC4	ANAPC4	12869	-0.14	0.17	NO
115	CREBBP	CREBBP	CREBBP	12946	-0.14	0.17	NO
116	CDK7	CDK7	CDK7	13380	-0.15	0.15	NO
117	STAG2	STAG2	STAG2	13582	-0.16	0.15	NO
118	CDKN2B	CDKN2B	CDKN2B	13643	-0.16	0.16	NO
119	RBL1	RBL1	RBL1	13913	-0.18	0.15	NO
120	GADD45G	GADD45G	GADD45G	14893	-0.23	0.11	NO
121	CCND2	CCND2	CCND2	15253	-0.25	0.1	NO
122	RBL2	RBL2	RBL2	15586	-0.27	0.096	NO
123	WEE2	WEE2	WEE2	16994	-0.46	0.041	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HSPA6	HSPA6	HSPA6	402	0.39	0.018	YES
2	THOC4	THOC4	THOC4	1165	0.25	0.00095	YES
3	SF3B4	SF3B4	SF3B4	1350	0.23	0.014	YES
4	SNRPA1	SNRPA1	SNRPA1	1445	0.22	0.032	YES
5	SNRPG	SNRPG	SNRPG	1608	0.2	0.044	YES
6	EIF4A3	EIF4A3	EIF4A3	1627	0.2	0.064	YES
7	SNRPD1	SNRPD1	SNRPD1	1835	0.18	0.072	YES
8	PHF5A	PHF5A	PHF5A	1866	0.18	0.089	YES
9	SNRPE	SNRPE	SNRPE	2531	0.14	0.067	YES
10	SF3B14	SF3B14	SF3B14	2551	0.14	0.081	YES
11	RBM8A	RBM8A	RBM8A	2650	0.14	0.09	YES
12	SART1	SART1	SART1	2657	0.14	0.1	YES
13	PRPF3	PRPF3	PRPF3	2760	0.13	0.11	YES
14	PRPF40A	PRPF40A	PRPF40A	2840	0.13	0.12	YES
15	HSPA1B	HSPA1B	HSPA1B	2922	0.13	0.13	YES
16	SNRPD3	SNRPD3	SNRPD3	3125	0.12	0.13	YES
17	SNRNP40	SNRNP40	SNRNP40	3196	0.12	0.14	YES
18	HNRNPA3	HNRNPA3	HNRNPA3	3246	0.12	0.15	YES
19	PUF60	PUF60	PUF60	3308	0.11	0.16	YES
20	PRPF38A	PRPF38A	PRPF38A	3330	0.11	0.17	YES
21	SFRS7	SFRS7	SFRS7	3527	0.1	0.17	YES
22	SF3B2	SF3B2	SF3B2	3549	0.1	0.18	YES
23	CCDC12	CCDC12	CCDC12	3595	0.1	0.19	YES
24	SNRPC	SNRPC	SNRPC	3632	0.1	0.2	YES
25	LSM2	LSM2	LSM2	3773	0.097	0.2	YES
26	SNRNP27	SNRNP27	SNRNP27	3800	0.096	0.2	YES
27	USP39	USP39	USP39	3876	0.094	0.21	YES
28	LSM4	LSM4	LSM4	3964	0.091	0.22	YES
29	LSM3	LSM3	LSM3	3968	0.091	0.22	YES
30	DHX16	DHX16	DHX16	3986	0.091	0.23	YES
31	SMNDC1	SMNDC1	SMNDC1	3995	0.09	0.24	YES
32	NHP2L1	NHP2L1	NHP2L1	4024	0.089	0.25	YES
33	U2AF1	U2AF1	U2AF1	4040	0.089	0.26	YES
34	PRPF4	PRPF4	PRPF4	4068	0.088	0.27	YES
35	LSM7	LSM7	LSM7	4099	0.087	0.27	YES
36	THOC1	THOC1	THOC1	4166	0.085	0.28	YES
37	SFRS3	SFRS3	SFRS3	4370	0.08	0.28	YES
38	TXNL4A	TXNL4A	TXNL4A	4466	0.076	0.28	YES
39	CWC15	CWC15	CWC15	4477	0.076	0.29	YES
40	SF3A2	SF3A2	SF3A2	4581	0.073	0.29	YES
41	ISY1	ISY1	ISY1	4722	0.069	0.29	YES
42	SNRPA	SNRPA	SNRPA	4732	0.069	0.29	YES
43	SF3B5	SF3B5	SF3B5	4834	0.066	0.3	YES
44	SF3B1	SF3B1	SF3B1	4906	0.064	0.3	YES
45	HNRNPU	HNRNPU	HNRNPU	4929	0.064	0.3	YES
46	HSPA1A	HSPA1A	HSPA1A	4952	0.063	0.31	YES
47	SFRS2	SFRS2	SFRS2	4986	0.062	0.31	YES
48	NCBP1	NCBP1	NCBP1	5107	0.06	0.31	YES
49	SNRNP70	SNRNP70	SNRNP70	5183	0.058	0.32	YES
50	RBM17	RBM17	RBM17	5242	0.056	0.32	YES
51	CDC40	CDC40	CDC40	5453	0.051	0.31	YES
52	TRA2A	TRA2A	TRA2A	5552	0.048	0.31	YES
53	EFTUD2	EFTUD2	EFTUD2	5693	0.044	0.31	YES
54	TRA2B	TRA2B	TRA2B	5702	0.044	0.31	YES
55	SFRS1	SFRS1	SFRS1	5769	0.042	0.31	YES
56	HSPA1L	HSPA1L	HSPA1L	5793	0.042	0.32	YES
57	SNW1	SNW1	SNW1	5814	0.041	0.32	YES
58	BUD31	BUD31	BUD31	5833	0.041	0.32	YES
59	PCBP1	PCBP1	PCBP1	5854	0.04	0.32	YES
60	HNRNPM	HNRNPM	HNRNPM	5887	0.039	0.33	YES
61	SF3A3	SF3A3	SF3A3	5934	0.039	0.33	YES
62	HNRNPC	HNRNPC	HNRNPC	5948	0.038	0.33	YES
63	BAT1	BAT1	BAT1	5966	0.038	0.34	YES
64	PPIE	PPIE	PPIE	6038	0.036	0.34	YES
65	NAA38	NAA38	NAA38	6076	0.035	0.34	YES
66	SNRNP200	SNRNP200	SNRNP200	6090	0.035	0.34	YES
67	SFRS9	SFRS9	SFRS9	6097	0.035	0.34	YES
68	HNRNPA1	HNRNPA1	HNRNPA1	6175	0.033	0.34	NO
69	PRPF19	PRPF19	PRPF19	6299	0.03	0.34	NO
70	SFRS6	SFRS6	SFRS6	6411	0.027	0.34	NO
71	HNRNPA1L2	HNRNPA1L2	HNRNPA1L2	6430	0.027	0.34	NO
72	SNRPD2	SNRPD2	SNRPD2	6436	0.026	0.34	NO
73	SF3A1	SF3A1	SF3A1	6671	0.021	0.33	NO
74	MAGOH	MAGOH	MAGOH	6730	0.02	0.33	NO
75	DDX42	DDX42	DDX42	6752	0.02	0.33	NO
76	SNRPB	SNRPB	SNRPB	6803	0.018	0.33	NO
77	SNRPF	SNRPF	SNRPF	6855	0.017	0.33	NO
78	PPIH	PPIH	PPIH	7147	0.011	0.31	NO
79	LSM6	LSM6	LSM6	7273	0.0082	0.3	NO
80	HSPA8	HSPA8	HSPA8	7364	0.0062	0.3	NO
81	LSM5	LSM5	LSM5	7406	0.0051	0.3	NO
82	CDC5L	CDC5L	CDC5L	7463	0.004	0.3	NO
83	PPIL1	PPIL1	PPIL1	7499	0.0033	0.29	NO
84	DHX8	DHX8	DHX8	7600	0.0012	0.29	NO
85	DDX5	DDX5	DDX5	7622	0.00078	0.29	NO
86	ACIN1	ACIN1	ACIN1	7704	-0.0012	0.28	NO
87	HNRNPK	HNRNPK	HNRNPK	7857	-0.0047	0.27	NO
88	RBMX	RBMX	RBMX	8083	-0.0099	0.26	NO
89	SFRS13A	SFRS13A	SFRS13A	8115	-0.011	0.26	NO
90	SFRS4	SFRS4	SFRS4	8167	-0.012	0.26	NO
91	CTNNBL1	CTNNBL1	CTNNBL1	8196	-0.012	0.26	NO
92	RBM25	RBM25	RBM25	8306	-0.015	0.26	NO
93	PRPF38B	PRPF38B	PRPF38B	8320	-0.015	0.26	NO
94	PRPF31	PRPF31	PRPF31	8343	-0.015	0.26	NO
95	CHERP	CHERP	CHERP	8413	-0.017	0.25	NO
96	SF3B3	SF3B3	SF3B3	8548	-0.02	0.25	NO
97	XAB2	XAB2	XAB2	8613	-0.021	0.25	NO
98	PRPF8	PRPF8	PRPF8	8649	-0.022	0.25	NO
99	SFRS2B	SFRS2B	SFRS2B	8725	-0.024	0.25	NO
100	PRPF6	PRPF6	PRPF6	8984	-0.029	0.23	NO
101	DDX46	DDX46	DDX46	9000	-0.029	0.24	NO
102	PQBP1	PQBP1	PQBP1	9057	-0.031	0.24	NO
103	BCAS2	BCAS2	BCAS2	9110	-0.032	0.24	NO
104	SYF2	SYF2	SYF2	9152	-0.033	0.24	NO
105	DDX23	DDX23	DDX23	9246	-0.036	0.24	NO
106	SR140	SR140	SR140	9483	-0.042	0.23	NO
107	DHX38	DHX38	DHX38	9494	-0.042	0.23	NO
108	DHX15	DHX15	DHX15	9573	-0.044	0.23	NO
109	U2AF2	U2AF2	U2AF2	9664	-0.047	0.23	NO
110	PRPF18	PRPF18	PRPF18	9669	-0.047	0.24	NO
111	AQR	AQR	AQR	10566	-0.069	0.19	NO
112	WBP11	WBP11	WBP11	10812	-0.075	0.19	NO
113	SNRPB2	SNRPB2	SNRPB2	11037	-0.081	0.18	NO
114	TCERG1	TCERG1	TCERG1	11051	-0.081	0.19	NO
115	SFRS5	SFRS5	SFRS5	11237	-0.086	0.19	NO
116	ZMAT2	ZMAT2	ZMAT2	11428	-0.091	0.19	NO
117	RBM22	RBM22	RBM22	11684	-0.099	0.18	NO
118	MAGOHB	MAGOHB	MAGOHB	11729	-0.1	0.19	NO
119	PLRG1	PLRG1	PLRG1	12062	-0.11	0.18	NO
120	PRPF40B	PRPF40B	PRPF40B	12211	-0.11	0.19	NO
121	CRNKL1	CRNKL1	CRNKL1	12482	-0.12	0.18	NO
122	SLU7	SLU7	SLU7	12873	-0.14	0.18	NO
123	THOC3	THOC3	THOC3	13220	-0.15	0.17	NO
124	THOC2	THOC2	THOC2	13726	-0.17	0.16	NO
125	HSPA2	HSPA2	HSPA2	17472	-0.62	0.014	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLE2	POLE2	POLE2	347	0.41	0.069	YES
2	DNA2	DNA2	DNA2	652	0.32	0.12	YES
3	FEN1	FEN1	FEN1	687	0.32	0.19	YES
4	MCM6	MCM6	MCM6	1046	0.26	0.23	YES
5	MCM2	MCM2	MCM2	1182	0.25	0.27	YES
6	MCM5	MCM5	MCM5	1270	0.24	0.32	YES
7	POLE4	POLE4	POLE4	1451	0.22	0.36	YES
8	MCM7	MCM7	MCM7	1634	0.2	0.39	YES
9	RNASEH1	RNASEH1	RNASEH1	1849	0.18	0.42	YES
10	POLA2	POLA2	POLA2	2264	0.16	0.43	YES
11	POLD3	POLD3	POLD3	2402	0.15	0.45	YES
12	POLD1	POLD1	POLD1	2471	0.15	0.48	YES
13	MCM4	MCM4	MCM4	2694	0.14	0.5	YES
14	RFC4	RFC4	RFC4	2777	0.13	0.52	YES
15	MCM3	MCM3	MCM3	3110	0.12	0.53	YES
16	RFC2	RFC2	RFC2	3302	0.11	0.54	YES
17	PRIM2	PRIM2	PRIM2	3564	0.1	0.55	YES
18	POLD2	POLD2	POLD2	3619	0.1	0.57	YES
19	PRIM1	PRIM1	PRIM1	3936	0.092	0.57	YES
20	RNASEH2A	RNASEH2A	RNASEH2A	4529	0.074	0.55	NO
21	RFC3	RFC3	RFC3	4738	0.069	0.56	NO
22	LIG1	LIG1	LIG1	5040	0.061	0.55	NO
23	POLE3	POLE3	POLE3	5258	0.056	0.55	NO
24	RNASEH2B	RNASEH2B	RNASEH2B	6223	0.032	0.5	NO
25	PCNA	PCNA	PCNA	6243	0.032	0.51	NO
26	POLD4	POLD4	POLD4	6406	0.027	0.51	NO
27	RNASEH2C	RNASEH2C	RNASEH2C	6655	0.022	0.5	NO
28	RFC5	RFC5	RFC5	6738	0.02	0.5	NO
29	POLE	POLE	POLE	6826	0.018	0.5	NO
30	RPA3	RPA3	RPA3	8119	-0.011	0.43	NO
31	RPA1	RPA1	RPA1	8295	-0.014	0.42	NO
32	RPA2	RPA2	RPA2	8717	-0.023	0.4	NO
33	SSBP1	SSBP1	SSBP1	10423	-0.065	0.32	NO
34	RFC1	RFC1	RFC1	11238	-0.086	0.29	NO
35	RPA4	RPA4	RPA4	16301	-0.35	0.08	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TP53I3	TP53I3	TP53I3	30	0.66	0.057	YES
2	TP73	TP73	TP73	104	0.55	0.1	YES
3	RRM2	RRM2	RRM2	132	0.52	0.15	YES
4	GTSE1	GTSE1	GTSE1	155	0.5	0.19	YES
5	CCNB2	CCNB2	CCNB2	298	0.42	0.22	YES
6	CDK1	CDK1	CDK1	365	0.4	0.25	YES
7	TP53AIP1	TP53AIP1	TP53AIP1	665	0.32	0.26	YES
8	CCNE2	CCNE2	CCNE2	779	0.3	0.28	YES
9	PERP	PERP	PERP	877	0.29	0.3	YES
10	CHEK2	CHEK2	CHEK2	920	0.28	0.33	YES
11	CHEK1	CHEK1	CHEK1	959	0.28	0.35	YES
12	CDK6	CDK6	CDK6	1021	0.27	0.37	YES
13	LRDD	LRDD	LRDD	1099	0.26	0.39	YES
14	SFN	SFN	SFN	1288	0.23	0.4	YES
15	GADD45A	GADD45A	GADD45A	1476	0.21	0.41	YES
16	CCNB1	CCNB1	CCNB1	1566	0.21	0.42	YES
17	CASP9	CASP9	CASP9	1585	0.2	0.44	YES
18	SERPINE1	SERPINE1	SERPINE1	1930	0.18	0.44	YES
19	TNFRSF10B	TNFRSF10B	TNFRSF10B	2307	0.16	0.43	YES
20	BID	BID	BID	2538	0.14	0.43	YES
21	CASP8	CASP8	CASP8	2574	0.14	0.44	YES
22	CASP3	CASP3	CASP3	2652	0.14	0.45	YES
23	CCND1	CCND1	CCND1	2782	0.13	0.45	YES
24	EI24	EI24	EI24	3058	0.12	0.45	NO
25	RFWD2	RFWD2	RFWD2	3192	0.12	0.45	NO
26	BAX	BAX	BAX	3652	0.1	0.43	NO
27	DDB2	DDB2	DDB2	3658	0.1	0.44	NO
28	THBS1	THBS1	THBS1	4238	0.083	0.42	NO
29	CDKN2A	CDKN2A	CDKN2A	4437	0.077	0.41	NO
30	SESN1	SESN1	SESN1	4734	0.069	0.4	NO
31	SHISA5	SHISA5	SHISA5	5140	0.059	0.38	NO
32	MDM4	MDM4	MDM4	5177	0.058	0.39	NO
33	CDK2	CDK2	CDK2	5385	0.053	0.38	NO
34	BBC3	BBC3	BBC3	5462	0.051	0.38	NO
35	SESN3	SESN3	SESN3	5883	0.04	0.36	NO
36	RRM2B	RRM2B	RRM2B	6168	0.033	0.34	NO
37	CCNE1	CCNE1	CCNE1	6213	0.032	0.35	NO
38	CDKN1A	CDKN1A	CDKN1A	6292	0.03	0.34	NO
39	MDM2	MDM2	MDM2	6349	0.029	0.34	NO
40	PTEN	PTEN	PTEN	6877	0.017	0.32	NO
41	SERPINB5	SERPINB5	SERPINB5	7224	0.0093	0.3	NO
42	CDK4	CDK4	CDK4	7239	0.0089	0.3	NO
43	TP53	TP53	TP53	7338	0.0068	0.29	NO
44	RPRM	RPRM	RPRM	7610	0.00096	0.28	NO
45	CCND3	CCND3	CCND3	8164	-0.012	0.25	NO
46	ATM	ATM	ATM	8503	-0.019	0.23	NO
47	CYCS	CYCS	CYCS	8663	-0.022	0.22	NO
48	PPM1D	PPM1D	PPM1D	8743	-0.024	0.22	NO
49	IGFBP3	IGFBP3	IGFBP3	8849	-0.026	0.22	NO
50	ATR	ATR	ATR	9603	-0.045	0.18	NO
51	CCNB3	CCNB3	CCNB3	10017	-0.055	0.16	NO
52	SESN2	SESN2	SESN2	10923	-0.078	0.11	NO
53	TSC2	TSC2	TSC2	11005	-0.08	0.12	NO
54	CCNG1	CCNG1	CCNG1	11741	-0.1	0.084	NO
55	FAS	FAS	FAS	12535	-0.12	0.05	NO
56	GADD45B	GADD45B	GADD45B	12597	-0.13	0.058	NO
57	BAI1	BAI1	BAI1	12947	-0.14	0.05	NO
58	SIAH1	SIAH1	SIAH1	13595	-0.16	0.028	NO
59	RCHY1	RCHY1	RCHY1	13686	-0.17	0.038	NO
60	APAF1	APAF1	APAF1	14034	-0.18	0.034	NO
61	ZMAT3	ZMAT3	ZMAT3	14728	-0.22	0.015	NO
62	GADD45G	GADD45G	GADD45G	14893	-0.23	0.026	NO
63	CCND2	CCND2	CCND2	15253	-0.25	0.027	NO
64	CCNG2	CCNG2	CCNG2	15263	-0.25	0.049	NO
65	PMAIP1	PMAIP1	PMAIP1	15519	-0.27	0.059	NO
66	IGF1	IGF1	IGF1	16389	-0.36	0.041	NO
67	CD82	CD82	CD82	16538	-0.38	0.067	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EXOSC8	EXOSC8	EXOSC8	1030	0.27	-0.0038	YES
2	ENO3	ENO3	ENO3	1359	0.23	0.024	YES
3	RQCD1	RQCD1	RQCD1	1468	0.21	0.062	YES
4	HSPD1	HSPD1	HSPD1	1937	0.18	0.072	YES
5	DCPS	DCPS	DCPS	1964	0.18	0.11	YES
6	EXOSC4	EXOSC4	EXOSC4	2570	0.14	0.1	YES
7	EXOSC1	EXOSC1	EXOSC1	2798	0.13	0.12	YES
8	EXOSC2	EXOSC2	EXOSC2	3037	0.12	0.13	YES
9	PATL1	PATL1	PATL1	3147	0.12	0.14	YES
10	EDC3	EDC3	EDC3	3229	0.12	0.16	YES
11	ENO1	ENO1	ENO1	3604	0.1	0.16	YES
12	EXOSC6	EXOSC6	EXOSC6	3683	0.1	0.18	YES
13	LSM2	LSM2	LSM2	3773	0.097	0.2	YES
14	LSM4	LSM4	LSM4	3964	0.091	0.2	YES
15	LSM3	LSM3	LSM3	3968	0.091	0.22	YES
16	LSM1	LSM1	LSM1	4077	0.088	0.23	YES
17	LSM7	LSM7	LSM7	4099	0.087	0.25	YES
18	EXOSC7	EXOSC7	EXOSC7	4167	0.085	0.26	YES
19	PNPT1	PNPT1	PNPT1	4237	0.083	0.28	YES
20	CNOT3	CNOT3	CNOT3	4406	0.078	0.28	YES
21	PAPOLG	PAPOLG	PAPOLG	4539	0.074	0.29	YES
22	DCP2	DCP2	DCP2	4889	0.065	0.28	NO
23	C1D	C1D	C1D	5109	0.06	0.28	NO
24	EXOSC10	EXOSC10	EXOSC10	5517	0.05	0.27	NO
25	EXOSC3	EXOSC3	EXOSC3	5588	0.047	0.28	NO
26	CNOT10	CNOT10	CNOT10	5886	0.039	0.27	NO
27	NAA38	NAA38	NAA38	6076	0.035	0.26	NO
28	EDC4	EDC4	EDC4	6352	0.029	0.26	NO
29	CNOT2	CNOT2	CNOT2	6457	0.026	0.25	NO
30	ENO2	ENO2	ENO2	7041	0.013	0.22	NO
31	WDR61	WDR61	WDR61	7173	0.01	0.22	NO
32	LSM6	LSM6	LSM6	7273	0.0082	0.22	NO
33	LSM5	LSM5	LSM5	7406	0.0051	0.21	NO
34	EXOSC9	EXOSC9	EXOSC9	7576	0.0017	0.2	NO
35	SKIV2L	SKIV2L	SKIV2L	7753	-0.0024	0.19	NO
36	DCP1A	DCP1A	DCP1A	7847	-0.0045	0.18	NO
37	CNOT7	CNOT7	CNOT7	7882	-0.0053	0.18	NO
38	EXOSC5	EXOSC5	EXOSC5	7999	-0.0077	0.18	NO
39	PAPOLA	PAPOLA	PAPOLA	8150	-0.011	0.17	NO
40	CNOT6L	CNOT6L	CNOT6L	8634	-0.022	0.15	NO
41	DIS3	DIS3	DIS3	8726	-0.024	0.15	NO
42	CNOT1	CNOT1	CNOT1	8798	-0.025	0.15	NO
43	DDX6	DDX6	DDX6	9368	-0.039	0.13	NO
44	CNOT6	CNOT6	CNOT6	10018	-0.055	0.1	NO
45	XRN1	XRN1	XRN1	10457	-0.066	0.09	NO
46	PAPOLB	PAPOLB	PAPOLB	10759	-0.074	0.088	NO
47	SKIV2L2	SKIV2L2	SKIV2L2	11091	-0.082	0.087	NO
48	PARN	PARN	PARN	11123	-0.083	0.1	NO
49	MPHOSPH6	MPHOSPH6	MPHOSPH6	11754	-0.1	0.087	NO
50	ZCCHC7	ZCCHC7	ZCCHC7	12053	-0.11	0.092	NO
51	XRN2	XRN2	XRN2	12850	-0.13	0.075	NO
52	PAPD7	PAPD7	PAPD7	13017	-0.14	0.094	NO
53	DCP1B	DCP1B	DCP1B	13910	-0.18	0.079	NO
54	HSPA9	HSPA9	HSPA9	13961	-0.18	0.11	NO
55	CNOT4	CNOT4	CNOT4	14389	-0.2	0.13	NO
56	TTC37	TTC37	TTC37	15769	-0.29	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDC25A	CDC25A	CDC25A	109	0.54	0.18	YES
2	CDK1	CDK1	CDK1	365	0.4	0.3	YES
3	CDK6	CDK6	CDK6	1021	0.27	0.36	YES
4	TGFB2	TGFB2	TGFB2	1233	0.24	0.42	YES
5	SKP2	SKP2	SKP2	1495	0.21	0.48	YES
6	CCND1	CCND1	CCND1	2782	0.13	0.46	YES
7	SMAD3	SMAD3	SMAD3	3021	0.12	0.48	YES
8	DHFR	DHFR	DHFR	4181	0.085	0.45	YES
9	CDKN2A	CDKN2A	CDKN2A	4437	0.077	0.46	YES
10	TFDP1	TFDP1	TFDP1	4472	0.076	0.48	YES
11	SMAD4	SMAD4	SMAD4	4814	0.067	0.49	YES
12	TGFB3	TGFB3	TGFB3	5229	0.056	0.48	YES
13	CDK2	CDK2	CDK2	5385	0.053	0.49	YES
14	CCNE1	CCNE1	CCNE1	6213	0.032	0.46	NO
15	CDKN1A	CDKN1A	CDKN1A	6292	0.03	0.46	NO
16	TGFB1	TGFB1	TGFB1	6567	0.024	0.46	NO
17	CDK4	CDK4	CDK4	7239	0.0089	0.42	NO
18	TP53	TP53	TP53	7338	0.0068	0.42	NO
19	HDAC1	HDAC1	HDAC1	7532	0.0027	0.41	NO
20	GSK3B	GSK3B	GSK3B	8169	-0.012	0.38	NO
21	ATM	ATM	ATM	8503	-0.019	0.36	NO
22	ABL1	ABL1	ABL1	8542	-0.02	0.37	NO
23	CCNA1	CCNA1	CCNA1	9427	-0.041	0.33	NO
24	ATR	ATR	ATR	9603	-0.045	0.34	NO
25	CDKN1B	CDKN1B	CDKN1B	10878	-0.077	0.29	NO
26	RB1	RB1	RB1	12214	-0.11	0.26	NO
27	CDKN2B	CDKN2B	CDKN2B	13643	-0.16	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDK1	CDK1	CDK1	365	0.4	0.071	YES
2	CDC25C	CDC25C	CDC25C	751	0.31	0.12	YES
3	RPS6KA1	RPS6KA1	RPS6KA1	1114	0.25	0.16	YES
4	HRAS	HRAS	HRAS	1160	0.25	0.21	YES
5	ACTA1	ACTA1	ACTA1	1456	0.22	0.24	YES
6	ARPC2	ARPC2	ARPC2	1561	0.21	0.28	YES
7	CCNB1	CCNB1	CCNB1	1566	0.21	0.33	YES
8	ACTR3	ACTR3	ACTR3	2128	0.17	0.34	YES
9	PAQR7	PAQR7	PAQR7	2301	0.16	0.36	YES
10	ARPC1B	ARPC1B	ARPC1B	2607	0.14	0.38	YES
11	PAQR5	PAQR5	PAQR5	2725	0.14	0.4	YES
12	ARPC5	ARPC5	ARPC5	3068	0.12	0.41	YES
13	ARPC4	ARPC4	ARPC4	3282	0.11	0.42	YES
14	ACTR2	ACTR2	ACTR2	4403	0.079	0.38	NO
15	PRKAR2B	PRKAR2B	PRKAR2B	5300	0.055	0.34	NO
16	PIN1	PIN1	PIN1	5393	0.053	0.35	NO
17	MAPK1	MAPK1	MAPK1	5704	0.044	0.34	NO
18	GNB1	GNB1	GNB1	5711	0.044	0.35	NO
19	ARPC1A	ARPC1A	ARPC1A	8519	-0.019	0.2	NO
20	CAP1	CAP1	CAP1	8864	-0.027	0.18	NO
21	PRKAR1B	PRKAR1B	PRKAR1B	8969	-0.029	0.18	NO
22	ARPC3	ARPC3	ARPC3	10140	-0.058	0.13	NO
23	PRKACB	PRKACB	PRKACB	10493	-0.067	0.13	NO
24	MAPK3	MAPK3	MAPK3	10570	-0.069	0.14	NO
25	GNAS	GNAS	GNAS	10723	-0.073	0.15	NO
26	PRKAR1A	PRKAR1A	PRKAR1A	10768	-0.074	0.16	NO
27	PRKAR2A	PRKAR2A	PRKAR2A	10996	-0.08	0.17	NO
28	PGR	PGR	PGR	11313	-0.088	0.17	NO
29	SRC	SRC	SRC	13200	-0.15	0.095	NO
30	GNAI1	GNAI1	GNAI1	13465	-0.16	0.12	NO
31	MYT1	MYT1	MYT1	15487	-0.27	0.062	NO
32	PRKACG	PRKACG	PRKACG	15671	-0.28	0.12	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA NO1 PATHWAY	27	genes.ES.table	0.59	1.6	0.024	0.8	0.65	0.33	0.15	0.28	0.48	0.29
BIOCARTA AGR PATHWAY	33	genes.ES.table	0.39	1.3	0.16	0.68	0.99	0.24	0.12	0.21	0.6	0.19
BIOCARTA ALK PATHWAY	34	genes.ES.table	0.52	1.5	0.028	0.8	0.81	0.29	0.21	0.23	0.56	0.29
BIOCARTA VIP PATHWAY	25	genes.ES.table	0.48	1.4	0.13	0.65	0.95	0.44	0.33	0.3	0.52	0.19
BIOCARTA CHREBP2 PATHWAY	41	genes.ES.table	0.38	1.3	0.16	0.63	0.98	0.12	0.091	0.11	0.55	0.16
BIOCARTA WNT PATHWAY	25	genes.ES.table	0.52	1.8	0.013	0.53	0.34	0.6	0.38	0.37	0	0.19
KEGG CYSTEINE AND METHIONINE METABOLISM	32	genes.ES.table	0.43	1.4	0.08	0.65	0.94	0.16	0.1	0.14	0.51	0.2
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE	25	genes.ES.table	0.46	1.3	0.16	0.61	0.98	0.2	0.13	0.18	0.53	0.15
KEGG MAPK SIGNALING PATHWAY	246	genes.ES.table	0.34	1.3	0.064	0.66	0.97	0.22	0.16	0.19	0.56	0.18
KEGG WNT SIGNALING PATHWAY	144	genes.ES.table	0.39	1.5	0.038	0.84	0.91	0.33	0.22	0.26	0.64	0.31

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	WIF1	WIF1	WIF1	204	0.57	0.19	YES
2	LEF1	LEF1	LEF1	218	0.57	0.39	YES
3	TLE1	TLE1	TLE1	2162	0.22	0.35	YES
4	MYC	MYC	MYC	2845	0.18	0.38	YES
5	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.4	YES
6	CCND1	CCND1	CCND1	3579	0.14	0.44	YES
7	FRAT1	FRAT1	FRAT1	4165	0.12	0.45	YES
8	BTRC	BTRC	BTRC	4421	0.11	0.48	YES
9	APC	APC	APC	5010	0.097	0.48	YES
10	GSK3B	GSK3B	GSK3B	5332	0.088	0.49	YES
11	FZD1	FZD1	FZD1	5728	0.078	0.49	YES
12	CSNK1A1	CSNK1A1	CSNK1A1	5853	0.075	0.51	YES
13	WNT1	WNT1	WNT1	6283	0.066	0.51	YES
14	NLK	NLK	NLK	6569	0.059	0.52	YES
15	CREBBP	CREBBP	CREBBP	6766	0.055	0.52	YES
16	CSNK2A1	CSNK2A1	CSNK2A1	8245	0.026	0.45	NO
17	AXIN1	AXIN1	AXIN1	8325	0.025	0.45	NO
18	MAP3K7	MAP3K7	MAP3K7	9085	0.011	0.41	NO
19	PPP2CA	PPP2CA	PPP2CA	9144	0.0098	0.41	NO
20	CSNK1D	CSNK1D	CSNK1D	9591	0.0015	0.39	NO
21	CTBP1	CTBP1	CTBP1	10485	-0.016	0.34	NO
22	SMAD4	SMAD4	SMAD4	10531	-0.017	0.35	NO
23	DVL1	DVL1	DVL1	11135	-0.028	0.32	NO
24	TAB1	TAB1	TAB1	11317	-0.032	0.32	NO
25	HDAC1	HDAC1	HDAC1	14183	-0.11	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PDE2A	PDE2A	PDE2A	54	0.73	0.18	YES
2	RYR2	RYR2	RYR2	589	0.42	0.26	YES
3	SLC7A1	SLC7A1	SLC7A1	1092	0.33	0.31	YES
4	PRKAR1B	PRKAR1B	PRKAR1B	1343	0.3	0.37	YES
5	PDE3A	PDE3A	PDE3A	1533	0.28	0.43	YES
6	PRKAR2B	PRKAR2B	PRKAR2B	1609	0.27	0.5	YES
7	PRKG1	PRKG1	PRKG1	1808	0.25	0.55	YES
8	PDE3B	PDE3B	PDE3B	2652	0.19	0.55	YES
9	PRKAR2A	PRKAR2A	PRKAR2A	2689	0.19	0.59	YES
10	FLT1	FLT1	FLT1	5329	0.088	0.46	NO
11	PRKACG	PRKACG	PRKACG	5438	0.085	0.48	NO
12	VEGFA	VEGFA	VEGFA	5499	0.084	0.5	NO
13	CALM1	CALM1	CALM1	7458	0.042	0.4	NO
14	CALM3	CALM3	CALM3	8416	0.023	0.35	NO
15	AKT1	AKT1	AKT1	8859	0.015	0.33	NO
16	CALM2	CALM2	CALM2	8948	0.014	0.33	NO
17	PRKAR1A	PRKAR1A	PRKAR1A	9822	-0.0028	0.28	NO
18	HSP90AA1	HSP90AA1	HSP90AA1	10070	-0.0077	0.26	NO
19	PRKACB	PRKACB	PRKACB	10326	-0.012	0.25	NO
20	KNG1	KNG1	KNG1	10603	-0.018	0.24	NO
21	KDR	KDR	KDR	10775	-0.021	0.24	NO
22	NOS3	NOS3	NOS3	12342	-0.054	0.16	NO
23	FLT4	FLT4	FLT4	12359	-0.055	0.18	NO
24	PRKG2	PRKG2	PRKG2	13074	-0.072	0.15	NO
25	ACTA1	ACTA1	ACTA1	14350	-0.11	0.11	NO
26	BDKRB2	BDKRB2	BDKRB2	14719	-0.13	0.12	NO
27	CHRNA1	CHRNA1	CHRNA1	15744	-0.19	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	WNT4	WNT4	WNT4	108	0.65	0.055	YES
2	LEF1	LEF1	LEF1	218	0.57	0.1	YES
3	AXIN2	AXIN2	AXIN2	350	0.5	0.14	YES
4	GLI1	GLI1	GLI1	368	0.49	0.19	YES
5	SHH	SHH	SHH	487	0.46	0.22	YES
6	BMP4	BMP4	BMP4	556	0.43	0.26	YES
7	SMO	SMO	SMO	656	0.41	0.29	YES
8	WNT9A	WNT9A	WNT9A	1076	0.34	0.3	YES
9	TCF7	TCF7	TCF7	1094	0.33	0.33	YES
10	FZD10	FZD10	FZD10	1125	0.33	0.36	YES
11	WNT10B	WNT10B	WNT10B	1336	0.3	0.38	YES
12	FZD7	FZD7	FZD7	1362	0.3	0.4	YES
13	FZD6	FZD6	FZD6	1551	0.28	0.42	YES
14	PTCH2	PTCH2	PTCH2	1585	0.28	0.44	YES
15	FZD9	FZD9	FZD9	1621	0.27	0.46	YES
16	GLI3	GLI3	GLI3	1651	0.27	0.49	YES
17	HHIP	HHIP	HHIP	2052	0.23	0.49	YES
18	APC2	APC2	APC2	2133	0.23	0.5	YES
19	PTCH1	PTCH1	PTCH1	2185	0.22	0.52	YES
20	WNT5A	WNT5A	WNT5A	2446	0.2	0.52	YES
21	FZD8	FZD8	FZD8	2592	0.2	0.54	YES
22	WNT3	WNT3	WNT3	2981	0.17	0.53	YES
23	TCF7L2	TCF7L2	TCF7L2	3024	0.17	0.54	YES
24	WNT16	WNT16	WNT16	3241	0.16	0.55	YES
25	WNT2	WNT2	WNT2	3359	0.15	0.55	YES
26	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.56	YES
27	GLI2	GLI2	GLI2	4049	0.13	0.54	NO
28	TCF7L1	TCF7L1	TCF7L1	4210	0.12	0.54	NO
29	WNT6	WNT6	WNT6	4856	0.1	0.52	NO
30	APC	APC	APC	5010	0.097	0.52	NO
31	SUFU	SUFU	SUFU	5171	0.092	0.52	NO
32	GSK3B	GSK3B	GSK3B	5332	0.088	0.52	NO
33	TP53	TP53	TP53	5427	0.086	0.52	NO
34	FZD3	FZD3	FZD3	5537	0.082	0.52	NO
35	WNT11	WNT11	WNT11	5672	0.08	0.52	NO
36	FZD1	FZD1	FZD1	5728	0.078	0.52	NO
37	DVL3	DVL3	DVL3	5971	0.073	0.52	NO
38	WNT1	WNT1	WNT1	6283	0.066	0.5	NO
39	WNT7B	WNT7B	WNT7B	6321	0.065	0.51	NO
40	BMP2	BMP2	BMP2	6924	0.052	0.48	NO
41	FZD5	FZD5	FZD5	7375	0.043	0.46	NO
42	AXIN1	AXIN1	AXIN1	8325	0.025	0.41	NO
43	WNT8B	WNT8B	WNT8B	9877	-0.004	0.32	NO
44	DVL1	DVL1	DVL1	11135	-0.028	0.25	NO
45	DVL2	DVL2	DVL2	12119	-0.049	0.2	NO
46	WNT10A	WNT10A	WNT10A	12752	-0.064	0.17	NO
47	STK36	STK36	STK36	12829	-0.066	0.17	NO
48	FZD2	FZD2	FZD2	12974	-0.07	0.17	NO
49	FZD4	FZD4	FZD4	13521	-0.086	0.15	NO
50	WNT2B	WNT2B	WNT2B	14533	-0.12	0.1	NO
51	WNT9B	WNT9B	WNT9B	15392	-0.17	0.068	NO
52	WNT7A	WNT7A	WNT7A	15580	-0.18	0.074	NO
53	WNT5B	WNT5B	WNT5B	17580	-0.5	0.0078	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CHRD	CHRD	CHRD	144	0.62	0.13	YES
2	TGFB2	TGFB2	TGFB2	299	0.52	0.24	YES
3	NOG	NOG	NOG	395	0.48	0.34	YES
4	BMP4	BMP4	BMP4	556	0.43	0.42	YES
5	BMP7	BMP7	BMP7	1029	0.34	0.47	YES
6	NKX2-5	NKX2-5	NKX2-5	1873	0.25	0.48	YES
7	TGFB3	TGFB3	TGFB3	2437	0.2	0.5	YES
8	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.47	YES
9	RFC1	RFC1	RFC1	3656	0.14	0.49	YES
10	SMAD5	SMAD5	SMAD5	3710	0.14	0.52	YES
11	SMAD1	SMAD1	SMAD1	4907	0.1	0.47	NO
12	APC	APC	APC	5010	0.097	0.49	NO
13	GSK3B	GSK3B	GSK3B	5332	0.088	0.49	NO
14	FZD1	FZD1	FZD1	5728	0.078	0.48	NO
15	ATF2	ATF2	ATF2	5739	0.078	0.5	NO
16	BMPR1A	BMPR1A	BMPR1A	5987	0.072	0.5	NO
17	WNT1	WNT1	WNT1	6283	0.066	0.5	NO
18	BMP2	BMP2	BMP2	6924	0.052	0.48	NO
19	HNF1A	HNF1A	HNF1A	7956	0.032	0.43	NO
20	GATA4	GATA4	GATA4	7959	0.032	0.43	NO
21	BMPR2	BMPR2	BMPR2	7999	0.031	0.44	NO
22	AXIN1	AXIN1	AXIN1	8325	0.025	0.42	NO
23	NPPB	NPPB	NPPB	8726	0.018	0.41	NO
24	MAP3K7	MAP3K7	MAP3K7	9085	0.011	0.39	NO
25	TGFBR2	TGFBR2	TGFBR2	9502	0.003	0.36	NO
26	SMAD6	SMAD6	SMAD6	9791	-0.0024	0.35	NO
27	SMAD4	SMAD4	SMAD4	10531	-0.017	0.31	NO
28	MYL2	MYL2	MYL2	10625	-0.019	0.31	NO
29	TGFBR1	TGFBR1	TGFBR1	10908	-0.024	0.3	NO
30	TGFBR3	TGFBR3	TGFBR3	11034	-0.026	0.3	NO
31	DVL1	DVL1	DVL1	11135	-0.028	0.3	NO
32	TGFB1	TGFB1	TGFB1	12082	-0.048	0.26	NO
33	ACVR1	ACVR1	ACVR1	13232	-0.077	0.21	NO
34	NPPA	NPPA	NPPA	15905	-0.21	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TAS2R31	TAS2R31	TAS2R31	48	0.76	0.076	YES
2	CACNA1B	CACNA1B	CACNA1B	84	0.67	0.14	YES
3	TAS2R14	TAS2R14	TAS2R14	97	0.66	0.21	YES
4	TAS2R46	TAS2R46	TAS2R46	327	0.51	0.25	YES
5	TAS2R43	TAS2R43	TAS2R43	349	0.5	0.3	YES
6	KCNB1	KCNB1	KCNB1	408	0.48	0.35	YES
7	TAS2R10	TAS2R10	TAS2R10	431	0.47	0.4	YES
8	GNB3	GNB3	GNB3	535	0.44	0.44	YES
9	TAS2R19	TAS2R19	TAS2R19	536	0.44	0.48	YES
10	TAS2R13	TAS2R13	TAS2R13	660	0.41	0.52	YES
11	TAS2R42	TAS2R42	TAS2R42	757	0.39	0.55	YES
12	TAS2R20	TAS2R20	TAS2R20	1469	0.28	0.54	YES
13	TAS2R50	TAS2R50	TAS2R50	1696	0.26	0.56	YES
14	CACNA1A	CACNA1A	CACNA1A	2413	0.21	0.54	YES
15	TAS2R5	TAS2R5	TAS2R5	2414	0.21	0.56	YES
16	PRKX	PRKX	PRKX	2544	0.2	0.57	YES
17	ADCY6	ADCY6	ADCY6	3791	0.14	0.52	NO
18	PRKACG	PRKACG	PRKACG	5438	0.085	0.43	NO
19	ACCN1	ACCN1	ACCN1	6660	0.057	0.37	NO
20	PRKACA	PRKACA	PRKACA	6667	0.057	0.38	NO
21	ADCY8	ADCY8	ADCY8	7530	0.04	0.33	NO
22	SCNN1B	SCNN1B	SCNN1B	7545	0.04	0.33	NO
23	GRM4	GRM4	GRM4	8667	0.019	0.27	NO
24	SCNN1G	SCNN1G	SCNN1G	9447	0.0039	0.23	NO
25	PRKACB	PRKACB	PRKACB	10326	-0.012	0.18	NO
26	TAS1R1	TAS1R1	TAS1R1	11260	-0.03	0.13	NO
27	TAS2R4	TAS2R4	TAS2R4	11995	-0.046	0.094	NO
28	TRPM5	TRPM5	TRPM5	12459	-0.057	0.074	NO
29	GNAS	GNAS	GNAS	12830	-0.066	0.06	NO
30	GNB1	GNB1	GNB1	13288	-0.078	0.042	NO
31	PDE1A	PDE1A	PDE1A	14985	-0.14	-0.039	NO
32	TAS1R3	TAS1R3	TAS1R3	15936	-0.21	-0.072	NO
33	GNG3	GNG3	GNG3	15955	-0.21	-0.05	NO
34	SCNN1A	SCNN1A	SCNN1A	15970	-0.21	-0.029	NO
35	ADCY4	ADCY4	ADCY4	16192	-0.24	-0.017	NO
36	PLCB2	PLCB2	PLCB2	16947	-0.32	-0.026	NO
37	ITPR3	ITPR3	ITPR3	17695	-0.67	0.0012	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NKD1	NKD1	NKD1	52	0.74	0.03	YES
2	WNT4	WNT4	WNT4	108	0.65	0.056	YES
3	NFATC4	NFATC4	NFATC4	180	0.59	0.079	YES
4	WIF1	WIF1	WIF1	204	0.57	0.1	YES
5	LEF1	LEF1	LEF1	218	0.57	0.13	YES
6	PRICKLE1	PRICKLE1	PRICKLE1	246	0.55	0.15	YES
7	AXIN2	AXIN2	AXIN2	350	0.5	0.17	YES
8	VANGL2	VANGL2	VANGL2	549	0.44	0.18	YES
9	CAMK2B	CAMK2B	CAMK2B	573	0.43	0.19	YES
10	CSNK1A1L	CSNK1A1L	CSNK1A1L	750	0.39	0.2	YES
11	SFRP5	SFRP5	SFRP5	859	0.37	0.21	YES
12	NFATC2	NFATC2	NFATC2	869	0.37	0.23	YES
13	PRKCG	PRKCG	PRKCG	1002	0.35	0.24	YES
14	WNT9A	WNT9A	WNT9A	1076	0.34	0.25	YES
15	TCF7	TCF7	TCF7	1094	0.33	0.26	YES
16	FZD10	FZD10	FZD10	1125	0.33	0.27	YES
17	SFRP4	SFRP4	SFRP4	1322	0.3	0.28	YES
18	WNT10B	WNT10B	WNT10B	1336	0.3	0.29	YES
19	FZD7	FZD7	FZD7	1362	0.3	0.3	YES
20	MAPK8	MAPK8	MAPK8	1399	0.29	0.31	YES
21	FZD6	FZD6	FZD6	1551	0.28	0.32	YES
22	FZD9	FZD9	FZD9	1621	0.27	0.32	YES
23	TBL1X	TBL1X	TBL1X	1980	0.24	0.31	YES
24	APC2	APC2	APC2	2133	0.23	0.32	YES
25	LRP5	LRP5	LRP5	2209	0.22	0.32	YES
26	WNT5A	WNT5A	WNT5A	2446	0.2	0.32	YES
27	CXXC4	CXXC4	CXXC4	2458	0.2	0.33	YES
28	PRKX	PRKX	PRKX	2544	0.2	0.33	YES
29	FZD8	FZD8	FZD8	2592	0.2	0.34	YES
30	PLCB4	PLCB4	PLCB4	2619	0.19	0.34	YES
31	MYC	MYC	MYC	2845	0.18	0.34	YES
32	WNT3	WNT3	WNT3	2981	0.17	0.34	YES
33	CTBP2	CTBP2	CTBP2	2998	0.17	0.34	YES
34	TCF7L2	TCF7L2	TCF7L2	3024	0.17	0.35	YES
35	CAMK2G	CAMK2G	CAMK2G	3053	0.17	0.36	YES
36	SFRP1	SFRP1	SFRP1	3163	0.16	0.36	YES
37	PPP2R5E	PPP2R5E	PPP2R5E	3210	0.16	0.36	YES
38	WNT16	WNT16	WNT16	3241	0.16	0.37	YES
39	PLCB1	PLCB1	PLCB1	3301	0.16	0.37	YES
40	WNT2	WNT2	WNT2	3359	0.15	0.38	YES
41	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.38	YES
42	CCND1	CCND1	CCND1	3579	0.14	0.38	YES
43	LRP6	LRP6	LRP6	3602	0.14	0.38	YES
44	NKD2	NKD2	NKD2	3704	0.14	0.38	YES
45	FBXW11	FBXW11	FBXW11	3752	0.14	0.39	YES
46	FRAT2	FRAT2	FRAT2	3766	0.14	0.39	YES
47	DAAM2	DAAM2	DAAM2	3845	0.13	0.39	YES
48	DAAM1	DAAM1	DAAM1	4159	0.12	0.38	NO
49	FRAT1	FRAT1	FRAT1	4165	0.12	0.38	NO
50	TCF7L1	TCF7L1	TCF7L1	4210	0.12	0.39	NO
51	NFATC1	NFATC1	NFATC1	4384	0.12	0.38	NO
52	BTRC	BTRC	BTRC	4421	0.11	0.39	NO
53	NFAT5	NFAT5	NFAT5	4595	0.11	0.38	NO
54	SMAD3	SMAD3	SMAD3	4734	0.1	0.38	NO
55	MAPK10	MAPK10	MAPK10	4794	0.1	0.38	NO
56	WNT6	WNT6	WNT6	4856	0.1	0.38	NO
57	PPP3R1	PPP3R1	PPP3R1	4903	0.1	0.38	NO
58	PPP3CA	PPP3CA	PPP3CA	4977	0.098	0.38	NO
59	APC	APC	APC	5010	0.097	0.39	NO
60	PPP3CB	PPP3CB	PPP3CB	5186	0.092	0.38	NO
61	GSK3B	GSK3B	GSK3B	5332	0.088	0.38	NO
62	TBL1XR1	TBL1XR1	TBL1XR1	5351	0.088	0.38	NO
63	SKP1	SKP1	SKP1	5414	0.086	0.38	NO
64	TP53	TP53	TP53	5427	0.086	0.38	NO
65	PRKACG	PRKACG	PRKACG	5438	0.085	0.38	NO
66	FZD3	FZD3	FZD3	5537	0.082	0.38	NO
67	WNT11	WNT11	WNT11	5672	0.08	0.38	NO
68	CCND2	CCND2	CCND2	5680	0.079	0.38	NO
69	PPP2R5C	PPP2R5C	PPP2R5C	5696	0.079	0.38	NO
70	FZD1	FZD1	FZD1	5728	0.078	0.39	NO
71	CUL1	CUL1	CUL1	5820	0.076	0.38	NO
72	CSNK1A1	CSNK1A1	CSNK1A1	5853	0.075	0.39	NO
73	DVL3	DVL3	DVL3	5971	0.073	0.38	NO
74	EP300	EP300	EP300	5989	0.072	0.38	NO
75	PRICKLE2	PRICKLE2	PRICKLE2	6142	0.069	0.38	NO
76	CHD8	CHD8	CHD8	6162	0.069	0.38	NO
77	WNT1	WNT1	WNT1	6283	0.066	0.38	NO
78	WNT7B	WNT7B	WNT7B	6321	0.065	0.38	NO
79	SENP2	SENP2	SENP2	6374	0.064	0.38	NO
80	NLK	NLK	NLK	6569	0.059	0.37	NO
81	PRKACA	PRKACA	PRKACA	6667	0.057	0.37	NO
82	SMAD2	SMAD2	SMAD2	6705	0.056	0.37	NO
83	CSNK1E	CSNK1E	CSNK1E	6707	0.056	0.37	NO
84	CREBBP	CREBBP	CREBBP	6766	0.055	0.37	NO
85	MAPK9	MAPK9	MAPK9	6851	0.053	0.37	NO
86	PRKCB	PRKCB	PRKCB	6914	0.052	0.37	NO
87	SIAH1	SIAH1	SIAH1	7075	0.048	0.36	NO
88	FZD5	FZD5	FZD5	7375	0.043	0.34	NO
89	VANGL1	VANGL1	VANGL1	7656	0.037	0.33	NO
90	ROCK2	ROCK2	ROCK2	7797	0.035	0.32	NO
91	RAC1	RAC1	RAC1	7907	0.032	0.32	NO
92	PPP2R1A	PPP2R1A	PPP2R1A	7976	0.031	0.32	NO
93	DKK1	DKK1	DKK1	8103	0.029	0.31	NO
94	CSNK2A2	CSNK2A2	CSNK2A2	8173	0.028	0.31	NO
95	CTNNBIP1	CTNNBIP1	CTNNBIP1	8198	0.027	0.31	NO
96	CSNK2A1	CSNK2A1	CSNK2A1	8245	0.026	0.31	NO
97	AXIN1	AXIN1	AXIN1	8325	0.025	0.3	NO
98	CHP	CHP	CHP	8901	0.014	0.27	NO
99	MAP3K7	MAP3K7	MAP3K7	9085	0.011	0.26	NO
100	ROCK1	ROCK1	ROCK1	9110	0.01	0.26	NO
101	PPP2CA	PPP2CA	PPP2CA	9144	0.0098	0.26	NO
102	CAMK2D	CAMK2D	CAMK2D	9173	0.0093	0.26	NO
103	RHOA	RHOA	RHOA	9196	0.0089	0.26	NO
104	RAC3	RAC3	RAC3	9518	0.0027	0.24	NO
105	PSEN1	PSEN1	PSEN1	9832	-0.0031	0.22	NO
106	WNT8B	WNT8B	WNT8B	9877	-0.004	0.22	NO
107	PPP3CC	PPP3CC	PPP3CC	10241	-0.011	0.2	NO
108	PRKACB	PRKACB	PRKACB	10326	-0.012	0.19	NO
109	CTBP1	CTBP1	CTBP1	10485	-0.016	0.18	NO
110	SMAD4	SMAD4	SMAD4	10531	-0.017	0.18	NO
111	FOSL1	FOSL1	FOSL1	10890	-0.023	0.16	NO
112	NFATC3	NFATC3	NFATC3	10901	-0.023	0.16	NO
113	DVL1	DVL1	DVL1	11135	-0.028	0.15	NO
114	PPP2R5A	PPP2R5A	PPP2R5A	11211	-0.029	0.15	NO
115	RUVBL1	RUVBL1	RUVBL1	11442	-0.035	0.14	NO
116	PPP2CB	PPP2CB	PPP2CB	11552	-0.037	0.13	NO
117	WNT3A	WNT3A	WNT3A	11609	-0.038	0.13	NO
118	DVL2	DVL2	DVL2	12119	-0.049	0.1	NO
119	WNT10A	WNT10A	WNT10A	12752	-0.064	0.072	NO
120	PPP2R5D	PPP2R5D	PPP2R5D	12811	-0.066	0.072	NO
121	CHP2	CHP2	CHP2	12953	-0.069	0.067	NO
122	FZD2	FZD2	FZD2	12974	-0.07	0.069	NO
123	RBX1	RBX1	RBX1	13122	-0.074	0.064	NO
124	CSNK2B	CSNK2B	CSNK2B	13428	-0.083	0.05	NO
125	PORCN	PORCN	PORCN	13483	-0.084	0.051	NO
126	FZD4	FZD4	FZD4	13521	-0.086	0.053	NO
127	PLCB3	PLCB3	PLCB3	13681	-0.09	0.048	NO
128	SOX17	SOX17	SOX17	14435	-0.12	0.01	NO
129	MMP7	MMP7	MMP7	14520	-0.12	0.011	NO
130	WNT2B	WNT2B	WNT2B	14533	-0.12	0.015	NO
131	CACYBP	CACYBP	CACYBP	15062	-0.15	-0.0081	NO
132	JUN	JUN	JUN	15116	-0.15	-0.0044	NO
133	WNT9B	WNT9B	WNT9B	15392	-0.17	-0.013	NO
134	CCND3	CCND3	CCND3	15519	-0.17	-0.012	NO
135	WNT7A	WNT7A	WNT7A	15580	-0.18	-0.0074	NO
136	DKK2	DKK2	DKK2	15932	-0.21	-0.018	NO
137	PPP2R1B	PPP2R1B	PPP2R1B	15943	-0.21	-0.0092	NO
138	CAMK2A	CAMK2A	CAMK2A	15992	-0.21	-0.0024	NO
139	PPARD	PPARD	PPARD	16062	-0.22	0.0037	NO
140	PLCB2	PLCB2	PLCB2	16947	-0.32	-0.032	NO
141	SFRP2	SFRP2	SFRP2	17229	-0.37	-0.032	NO
142	RAC2	RAC2	RAC2	17321	-0.39	-0.019	NO
143	PRKCA	PRKCA	PRKCA	17451	-0.44	-0.0071	NO
144	WNT5B	WNT5B	WNT5B	17580	-0.5	0.0078	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CTNNA2	CTNNA2	CTNNA2	86	0.66	0.039	YES
2	CACNA2D2	CACNA2D2	CACNA2D2	116	0.64	0.079	YES
3	CACNG2	CACNG2	CACNG2	133	0.63	0.12	YES
4	CACNB2	CACNB2	CACNB2	188	0.58	0.16	YES
5	LEF1	LEF1	LEF1	218	0.57	0.19	YES
6	CACNA2D1	CACNA2D1	CACNA2D1	286	0.52	0.22	YES
7	RYR2	RYR2	RYR2	589	0.42	0.23	YES
8	ITGA8	ITGA8	ITGA8	604	0.42	0.26	YES
9	CACNA1S	CACNA1S	CACNA1S	652	0.41	0.28	YES
10	ITGA9	ITGA9	ITGA9	777	0.38	0.3	YES
11	ITGB8	ITGB8	ITGB8	778	0.38	0.33	YES
12	CACNA1D	CACNA1D	CACNA1D	877	0.37	0.34	YES
13	LAMA2	LAMA2	LAMA2	1058	0.34	0.36	YES
14	TCF7	TCF7	TCF7	1094	0.33	0.38	YES
15	CACNA1C	CACNA1C	CACNA1C	1201	0.32	0.39	YES
16	DMD	DMD	DMD	1619	0.27	0.39	YES
17	CACNG7	CACNG7	CACNG7	1748	0.26	0.4	YES
18	ITGA1	ITGA1	ITGA1	1787	0.25	0.41	YES
19	SGCD	SGCD	SGCD	1895	0.24	0.42	YES
20	CACNB1	CACNB1	CACNB1	2119	0.23	0.42	YES
21	ITGA2	ITGA2	ITGA2	2126	0.23	0.44	YES
22	CDH2	CDH2	CDH2	2163	0.22	0.45	YES
23	ITGA7	ITGA7	ITGA7	2179	0.22	0.46	YES
24	CACNB3	CACNB3	CACNB3	2201	0.22	0.48	YES
25	ACTN1	ACTN1	ACTN1	2237	0.22	0.49	YES
26	PKP2	PKP2	PKP2	2786	0.18	0.47	NO
27	TCF7L2	TCF7L2	TCF7L2	3024	0.17	0.47	NO
28	ITGB5	ITGB5	ITGB5	3057	0.17	0.48	NO
29	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.46	NO
30	CACNB4	CACNB4	CACNB4	4065	0.13	0.44	NO
31	TCF7L1	TCF7L1	TCF7L1	4210	0.12	0.44	NO
32	SGCB	SGCB	SGCB	4274	0.12	0.44	NO
33	SGCA	SGCA	SGCA	4925	0.099	0.41	NO
34	ITGA11	ITGA11	ITGA11	5080	0.095	0.41	NO
35	ITGA10	ITGA10	ITGA10	5304	0.089	0.4	NO
36	SGCG	SGCG	SGCG	6571	0.059	0.33	NO
37	ITGA2B	ITGA2B	ITGA2B	7205	0.046	0.3	NO
38	ITGB1	ITGB1	ITGB1	7295	0.044	0.3	NO
39	DES	DES	DES	7682	0.037	0.28	NO
40	ITGA6	ITGA6	ITGA6	9037	0.012	0.2	NO
41	EMD	EMD	EMD	9105	0.011	0.2	NO
42	CTNNA1	CTNNA1	CTNNA1	9577	0.0017	0.17	NO
43	ACTN3	ACTN3	ACTN3	9812	-0.0026	0.16	NO
44	CACNG4	CACNG4	CACNG4	10121	-0.0086	0.14	NO
45	ACTN2	ACTN2	ACTN2	10857	-0.023	0.1	NO
46	DAG1	DAG1	DAG1	10977	-0.025	0.098	NO
47	JUP	JUP	JUP	11558	-0.037	0.068	NO
48	ACTN4	ACTN4	ACTN4	12412	-0.056	0.023	NO
49	ITGAV	ITGAV	ITGAV	12710	-0.063	0.011	NO
50	ACTB	ACTB	ACTB	12718	-0.063	0.014	NO
51	ACTG1	ACTG1	ACTG1	12796	-0.065	0.014	NO
52	CTNNA3	CTNNA3	CTNNA3	13198	-0.076	-0.0035	NO
53	DSP	DSP	DSP	13284	-0.078	-0.0032	NO
54	LMNA	LMNA	LMNA	13782	-0.093	-0.025	NO
55	ATP2A2	ATP2A2	ATP2A2	14250	-0.11	-0.044	NO
56	DSG2	DSG2	DSG2	14332	-0.11	-0.042	NO
57	ITGA3	ITGA3	ITGA3	14530	-0.12	-0.045	NO
58	ITGB7	ITGB7	ITGB7	14814	-0.13	-0.052	NO
59	ITGB3	ITGB3	ITGB3	15039	-0.14	-0.056	NO
60	CACNA2D3	CACNA2D3	CACNA2D3	15071	-0.15	-0.048	NO
61	CACNA1F	CACNA1F	CACNA1F	15302	-0.16	-0.05	NO
62	ITGA5	ITGA5	ITGA5	16012	-0.22	-0.076	NO
63	CACNG1	CACNG1	CACNG1	16184	-0.24	-0.07	NO
64	GJA1	GJA1	GJA1	16378	-0.25	-0.065	NO
65	ITGB4	ITGB4	ITGB4	16511	-0.27	-0.055	NO
66	ITGA4	ITGA4	ITGA4	16548	-0.27	-0.039	NO
67	SLC8A1	SLC8A1	SLC8A1	16920	-0.32	-0.039	NO
68	DSC2	DSC2	DSC2	17068	-0.34	-0.025	NO
69	CACNA2D4	CACNA2D4	CACNA2D4	17327	-0.39	-0.014	NO
70	ITGB6	ITGB6	ITGB6	17634	-0.55	0.0047	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	WNT4	WNT4	WNT4	108	0.65	0.056	YES
2	BMP6	BMP6	BMP6	230	0.56	0.1	YES
3	GLI1	GLI1	GLI1	368	0.49	0.14	YES
4	SHH	SHH	SHH	487	0.46	0.18	YES
5	BMP4	BMP4	BMP4	556	0.43	0.22	YES
6	IHH	IHH	IHH	591	0.42	0.25	YES
7	SMO	SMO	SMO	656	0.41	0.29	YES
8	CSNK1A1L	CSNK1A1L	CSNK1A1L	750	0.39	0.32	YES
9	BMP7	BMP7	BMP7	1029	0.34	0.34	YES
10	WNT9A	WNT9A	WNT9A	1076	0.34	0.37	YES
11	WNT10B	WNT10B	WNT10B	1336	0.3	0.38	YES
12	PTCH2	PTCH2	PTCH2	1585	0.28	0.39	YES
13	GLI3	GLI3	GLI3	1651	0.27	0.42	YES
14	HHIP	HHIP	HHIP	2052	0.23	0.42	YES
15	PTCH1	PTCH1	PTCH1	2185	0.22	0.43	YES
16	WNT5A	WNT5A	WNT5A	2446	0.2	0.43	YES
17	BMP8B	BMP8B	BMP8B	2478	0.2	0.45	YES
18	PRKX	PRKX	PRKX	2544	0.2	0.47	YES
19	ZIC2	ZIC2	ZIC2	2867	0.18	0.47	YES
20	WNT3	WNT3	WNT3	2981	0.17	0.48	YES
21	LRP2	LRP2	LRP2	3078	0.17	0.49	YES
22	WNT16	WNT16	WNT16	3241	0.16	0.49	YES
23	WNT2	WNT2	WNT2	3359	0.15	0.5	YES
24	BMP8A	BMP8A	BMP8A	3592	0.14	0.5	YES
25	FBXW11	FBXW11	FBXW11	3752	0.14	0.5	YES
26	GLI2	GLI2	GLI2	4049	0.13	0.5	NO
27	CSNK1G3	CSNK1G3	CSNK1G3	4417	0.11	0.49	NO
28	BTRC	BTRC	BTRC	4421	0.11	0.5	NO
29	WNT6	WNT6	WNT6	4856	0.1	0.49	NO
30	SUFU	SUFU	SUFU	5171	0.092	0.48	NO
31	GSK3B	GSK3B	GSK3B	5332	0.088	0.48	NO
32	PRKACG	PRKACG	PRKACG	5438	0.085	0.48	NO
33	WNT11	WNT11	WNT11	5672	0.08	0.47	NO
34	CSNK1A1	CSNK1A1	CSNK1A1	5853	0.075	0.47	NO
35	WNT1	WNT1	WNT1	6283	0.066	0.45	NO
36	WNT7B	WNT7B	WNT7B	6321	0.065	0.46	NO
37	PRKACA	PRKACA	PRKACA	6667	0.057	0.44	NO
38	CSNK1E	CSNK1E	CSNK1E	6707	0.056	0.44	NO
39	BMP2	BMP2	BMP2	6924	0.052	0.44	NO
40	GAS1	GAS1	GAS1	7380	0.043	0.42	NO
41	CSNK1G1	CSNK1G1	CSNK1G1	7846	0.034	0.39	NO
42	CSNK1G2	CSNK1G2	CSNK1G2	8304	0.025	0.37	NO
43	CSNK1D	CSNK1D	CSNK1D	9591	0.0015	0.3	NO
44	WNT8B	WNT8B	WNT8B	9877	-0.004	0.28	NO
45	PRKACB	PRKACB	PRKACB	10326	-0.012	0.26	NO
46	WNT10A	WNT10A	WNT10A	12752	-0.064	0.13	NO
47	STK36	STK36	STK36	12829	-0.066	0.13	NO
48	WNT2B	WNT2B	WNT2B	14533	-0.12	0.043	NO
49	RAB23	RAB23	RAB23	14845	-0.14	0.039	NO
50	WNT9B	WNT9B	WNT9B	15392	-0.17	0.024	NO
51	WNT7A	WNT7A	WNT7A	15580	-0.18	0.03	NO
52	DHH	DHH	DHH	17509	-0.46	-0.036	NO
53	WNT5B	WNT5B	WNT5B	17580	-0.5	0.0078	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NKD1	NKD1	NKD1	52	0.74	0.054	YES
2	WNT4	WNT4	WNT4	108	0.65	0.1	YES
3	WIF1	WIF1	WIF1	204	0.57	0.14	YES
4	LEF1	LEF1	LEF1	218	0.57	0.18	YES
5	PYGO1	PYGO1	PYGO1	277	0.53	0.22	YES
6	WISP1	WISP1	WISP1	540	0.44	0.24	YES
7	WNT9A	WNT9A	WNT9A	1076	0.34	0.23	YES
8	TCF7	TCF7	TCF7	1094	0.33	0.26	YES
9	RHOU	RHOU	RHOU	1286	0.31	0.27	YES
10	SFRP4	SFRP4	SFRP4	1322	0.3	0.29	YES
11	FZD7	FZD7	FZD7	1362	0.3	0.31	YES
12	FZD6	FZD6	FZD6	1551	0.28	0.32	YES
13	TLE1	TLE1	TLE1	2162	0.22	0.3	YES
14	LRP5	LRP5	LRP5	2209	0.22	0.32	YES
15	WNT5A	WNT5A	WNT5A	2446	0.2	0.32	YES
16	CXXC4	CXXC4	CXXC4	2458	0.2	0.33	YES
17	FZD8	FZD8	FZD8	2592	0.2	0.34	YES
18	MYC	MYC	MYC	2845	0.18	0.34	YES
19	WNT3	WNT3	WNT3	2981	0.17	0.35	YES
20	CTBP2	CTBP2	CTBP2	2998	0.17	0.36	YES
21	SFRP1	SFRP1	SFRP1	3163	0.16	0.36	YES
22	WNT16	WNT16	WNT16	3241	0.16	0.37	YES
23	FRZB	FRZB	FRZB	3336	0.16	0.38	YES
24	WNT2	WNT2	WNT2	3359	0.15	0.39	YES
25	CTNNB1	CTNNB1	CTNNB1	3473	0.15	0.39	YES
26	CCND1	CCND1	CCND1	3579	0.14	0.4	YES
27	LRP6	LRP6	LRP6	3602	0.14	0.41	YES
28	FBXW11	FBXW11	FBXW11	3752	0.14	0.41	YES
29	DAAM1	DAAM1	DAAM1	4159	0.12	0.39	YES
30	FRAT1	FRAT1	FRAT1	4165	0.12	0.4	YES
31	TCF7L1	TCF7L1	TCF7L1	4210	0.12	0.41	YES
32	BTRC	BTRC	BTRC	4421	0.11	0.41	NO
33	WNT6	WNT6	WNT6	4856	0.1	0.39	NO
34	APC	APC	APC	5010	0.097	0.39	NO
35	GSK3B	GSK3B	GSK3B	5332	0.088	0.38	NO
36	FZD3	FZD3	FZD3	5537	0.082	0.37	NO
37	WNT11	WNT11	WNT11	5672	0.08	0.37	NO
38	CCND2	CCND2	CCND2	5680	0.079	0.38	NO
39	FZD1	FZD1	FZD1	5728	0.078	0.38	NO
40	CSNK1A1	CSNK1A1	CSNK1A1	5853	0.075	0.38	NO
41	EP300	EP300	EP300	5989	0.072	0.38	NO
42	FBXW2	FBXW2	FBXW2	6214	0.068	0.37	NO
43	GSK3A	GSK3A	GSK3A	6218	0.068	0.37	NO
44	WNT1	WNT1	WNT1	6283	0.066	0.37	NO
45	DIXDC1	DIXDC1	DIXDC1	6315	0.065	0.38	NO
46	WNT7B	WNT7B	WNT7B	6321	0.065	0.38	NO
47	FBXW4	FBXW4	FBXW4	6344	0.064	0.39	NO
48	SENP2	SENP2	SENP2	6374	0.064	0.39	NO
49	NLK	NLK	NLK	6569	0.059	0.38	NO
50	RPL13A	RPL13A	RPL13A	6921	0.052	0.37	NO
51	FZD5	FZD5	FZD5	7375	0.043	0.34	NO
52	CSNK1G1	CSNK1G1	CSNK1G1	7846	0.034	0.32	NO
53	PPP2R1A	PPP2R1A	PPP2R1A	7976	0.031	0.32	NO
54	DKK1	DKK1	DKK1	8103	0.029	0.31	NO
55	CTNNBIP1	CTNNBIP1	CTNNBIP1	8198	0.027	0.31	NO
56	CSNK2A1	CSNK2A1	CSNK2A1	8245	0.026	0.31	NO
57	AXIN1	AXIN1	AXIN1	8325	0.025	0.3	NO
58	HPRT1	HPRT1	HPRT1	8456	0.023	0.3	NO
59	PPP2CA	PPP2CA	PPP2CA	9144	0.0098	0.26	NO
60	CSNK1D	CSNK1D	CSNK1D	9591	0.0015	0.24	NO
61	GAPDH	GAPDH	GAPDH	10234	-0.011	0.2	NO
62	CTBP1	CTBP1	CTBP1	10485	-0.016	0.19	NO
63	FOSL1	FOSL1	FOSL1	10890	-0.023	0.16	NO
64	DVL1	DVL1	DVL1	11135	-0.028	0.15	NO
65	DVL2	DVL2	DVL2	12119	-0.049	0.1	NO
66	BCL9	BCL9	BCL9	12250	-0.052	0.098	NO
67	ACTB	ACTB	ACTB	12718	-0.063	0.076	NO
68	WNT10A	WNT10A	WNT10A	12752	-0.064	0.079	NO
69	FZD2	FZD2	FZD2	12974	-0.07	0.072	NO
70	AES	AES	AES	13114	-0.074	0.07	NO
71	PORCN	PORCN	PORCN	13483	-0.084	0.055	NO
72	FZD4	FZD4	FZD4	13521	-0.086	0.06	NO
73	SOX17	SOX17	SOX17	14435	-0.12	0.017	NO
74	TLE2	TLE2	TLE2	14460	-0.12	0.024	NO
75	SLC9A3R1	SLC9A3R1	SLC9A3R1	14493	-0.12	0.032	NO
76	WNT2B	WNT2B	WNT2B	14533	-0.12	0.039	NO
77	JUN	JUN	JUN	15116	-0.15	0.017	NO
78	CCND3	CCND3	CCND3	15519	-0.17	0.0074	NO
79	B2M	B2M	B2M	15543	-0.18	0.02	NO
80	WNT7A	WNT7A	WNT7A	15580	-0.18	0.031	NO
81	KREMEN1	KREMEN1	KREMEN1	16232	-0.24	0.012	NO
82	PITX2	PITX2	PITX2	17476	-0.45	-0.024	NO
83	WNT5B	WNT5B	WNT5B	17580	-0.5	0.0078	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDO1	CDO1	CDO1	156	0.61	0.17	YES
2	CBS	CBS	CBS	546	0.44	0.27	YES
3	SMS	SMS	SMS	1687	0.26	0.28	YES
4	TRDMT1	TRDMT1	TRDMT1	1722	0.26	0.36	YES
5	TAT	TAT	TAT	1814	0.25	0.43	YES
6	BHMT	BHMT	BHMT	4028	0.13	0.34	NO
7	MAT2B	MAT2B	MAT2B	5604	0.081	0.27	NO
8	MPST	MPST	MPST	5766	0.077	0.29	NO
9	LDHB	LDHB	LDHB	6316	0.065	0.27	NO
10	AHCYL2	AHCYL2	AHCYL2	6516	0.06	0.28	NO
11	DNMT3A	DNMT3A	DNMT3A	6653	0.058	0.29	NO
12	GOT1	GOT1	GOT1	6659	0.057	0.3	NO
13	CTH	CTH	CTH	7673	0.037	0.26	NO
14	GOT2	GOT2	GOT2	8365	0.024	0.23	NO
15	DNMT1	DNMT1	DNMT1	8502	0.022	0.22	NO
16	LDHAL6B	LDHAL6B	LDHAL6B	8591	0.02	0.23	NO
17	AHCY	AHCY	AHCY	8746	0.017	0.22	NO
18	MTR	MTR	MTR	8835	0.016	0.22	NO
19	MTAP	MTAP	MTAP	9559	0.002	0.18	NO
20	MAT2A	MAT2A	MAT2A	9771	-0.0019	0.17	NO
21	AMD1	AMD1	AMD1	10253	-0.011	0.15	NO
22	AHCYL1	AHCYL1	AHCYL1	10286	-0.012	0.15	NO
23	ENOPH1	ENOPH1	ENOPH1	10332	-0.013	0.15	NO
24	LDHAL6A	LDHAL6A	LDHAL6A	10942	-0.024	0.12	NO
25	APIP	APIP	APIP	12767	-0.064	0.037	NO
26	ADI1	ADI1	ADI1	12857	-0.067	0.052	NO
27	SRM	SRM	SRM	13000	-0.07	0.064	NO
28	LDHA	LDHA	LDHA	13583	-0.087	0.057	NO
29	SDS	SDS	SDS	14622	-0.12	0.034	NO
30	MAT1A	MAT1A	MAT1A	14695	-0.13	0.067	NO
31	IL4I1	IL4I1	IL4I1	15388	-0.17	0.076	NO
32	DNMT3B	DNMT3B	DNMT3B	15734	-0.19	0.11	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA AT1R PATHWAY	32	genes.ES.table	0.34	1.3	0.18	1	0.98	0.28	0.3	0.2	0.89	0.42
BIOCARTA EGF PATHWAY	30	genes.ES.table	0.46	1.4	0.15	1	0.96	0.17	0.072	0.16	0.81	0.4
BIOCARTA GH PATHWAY	26	genes.ES.table	0.43	1.4	0.083	1	0.95	0.15	0.054	0.15	1	0.52
BIOCARTA PYK2 PATHWAY	27	genes.ES.table	0.32	1.3	0.22	0.82	0.99	0.22	0.3	0.16	0.71	0.3
BIOCARTA CHREBP2 PATHWAY	41	genes.ES.table	0.34	1.2	0.24	0.79	0.99	0.32	0.27	0.23	0.69	0.27
BIOCARTA CREB PATHWAY	26	genes.ES.table	0.51	1.6	0.021	0.88	0.76	0.23	0.16	0.19	0.57	0.31
KEGG PENTOSE PHOSPHATE PATHWAY	25	genes.ES.table	0.42	1.3	0.17	0.87	0.99	0.48	0.34	0.32	0.75	0.34
KEGG STEROID HORMONE BIOSYNTHESIS	41	genes.ES.table	0.56	1.4	0.062	1	0.95	0.51	0.15	0.44	0.9	0.44
KEGG O GLYCAN BIOSYNTHESIS	27	genes.ES.table	0.45	1.3	0.12	0.78	0.99	0.41	0.2	0.33	0.67	0.28
KEGG BUTANOATE METABOLISM	30	genes.ES.table	0.57	1.5	0.044	0.81	0.8	0.6	0.29	0.42	0.53	0.29

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPA4	RPA4	RPA4	127	0.48	0.14	YES
2	ERCC4	ERCC4	ERCC4	1037	0.26	0.17	YES
3	ERCC8	ERCC8	ERCC8	2425	0.16	0.14	YES
4	GTF2H3	GTF2H3	GTF2H3	2734	0.14	0.17	YES
5	ERCC2	ERCC2	ERCC2	3079	0.13	0.19	YES
6	CDK7	CDK7	CDK7	3265	0.12	0.22	YES
7	GTF2H2	GTF2H2	GTF2H2	3407	0.12	0.24	YES
8	RPA3	RPA3	RPA3	3472	0.12	0.28	YES
9	LIG1	LIG1	LIG1	3639	0.11	0.3	YES
10	RPA2	RPA2	RPA2	3667	0.11	0.33	YES
11	POLE2	POLE2	POLE2	3781	0.11	0.36	YES
12	CUL4B	CUL4B	CUL4B	4248	0.097	0.36	YES
13	CUL4A	CUL4A	CUL4A	4256	0.096	0.39	YES
14	ERCC5	ERCC5	ERCC5	4634	0.088	0.4	YES
15	CCNH	CCNH	CCNH	4792	0.084	0.42	YES
16	RFC2	RFC2	RFC2	5625	0.067	0.39	NO
17	GTF2H5	GTF2H5	GTF2H5	5629	0.067	0.41	NO
18	CETN2	CETN2	CETN2	6064	0.059	0.4	NO
19	MNAT1	MNAT1	MNAT1	6213	0.056	0.41	NO
20	RFC1	RFC1	RFC1	6663	0.048	0.4	NO
21	RFC3	RFC3	RFC3	6930	0.043	0.4	NO
22	POLD1	POLD1	POLD1	7285	0.037	0.39	NO
23	GTF2H4	GTF2H4	GTF2H4	7626	0.031	0.38	NO
24	RFC5	RFC5	RFC5	7665	0.031	0.39	NO
25	POLE4	POLE4	POLE4	7798	0.029	0.39	NO
26	POLE3	POLE3	POLE3	7905	0.027	0.39	NO
27	POLD2	POLD2	POLD2	8191	0.022	0.38	NO
28	POLE	POLE	POLE	8248	0.021	0.39	NO
29	PCNA	PCNA	PCNA	8729	0.013	0.36	NO
30	POLD3	POLD3	POLD3	8924	0.0096	0.36	NO
31	RAD23A	RAD23A	RAD23A	9678	-0.0028	0.32	NO
32	DDB1	DDB1	DDB1	9815	-0.0048	0.31	NO
33	ERCC6	ERCC6	ERCC6	10019	-0.0078	0.3	NO
34	GTF2H1	GTF2H1	GTF2H1	10262	-0.012	0.29	NO
35	ERCC1	ERCC1	ERCC1	10697	-0.019	0.27	NO
36	ERCC3	ERCC3	ERCC3	10741	-0.02	0.28	NO
37	XPC	XPC	XPC	11060	-0.026	0.26	NO
38	RBX1	RBX1	RBX1	11852	-0.039	0.23	NO
39	POLD4	POLD4	POLD4	12096	-0.044	0.23	NO
40	RPA1	RPA1	RPA1	12994	-0.064	0.2	NO
41	RFC4	RFC4	RFC4	13072	-0.066	0.22	NO
42	XPA	XPA	XPA	13357	-0.073	0.22	NO
43	DDB2	DDB2	DDB2	13536	-0.077	0.24	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SOCS1	SOCS1	SOCS1	163	0.46	0.04	YES
2	PARK2	PARK2	PARK2	533	0.34	0.055	YES
3	NHLRC1	NHLRC1	NHLRC1	576	0.33	0.088	YES
4	UBE2NL	UBE2NL	UBE2NL	776	0.29	0.11	YES
5	HERC3	HERC3	HERC3	996	0.26	0.12	YES
6	UBE2QL1	UBE2QL1	UBE2QL1	1558	0.21	0.11	YES
7	ERCC8	ERCC8	ERCC8	2425	0.16	0.082	YES
8	UBE2D4	UBE2D4	UBE2D4	2654	0.15	0.084	YES
9	XIAP	XIAP	XIAP	3298	0.12	0.061	YES
10	UBE2C	UBE2C	UBE2C	3379	0.12	0.069	YES
11	CDC23	CDC23	CDC23	3499	0.12	0.074	YES
12	NEDD4	NEDD4	NEDD4	3550	0.11	0.084	YES
13	FBXO4	FBXO4	FBXO4	3644	0.11	0.09	YES
14	KLHL9	KLHL9	KLHL9	3882	0.11	0.088	YES
15	ANAPC10	ANAPC10	ANAPC10	3924	0.1	0.097	YES
16	UBE3C	UBE3C	UBE3C	4026	0.1	0.1	YES
17	UBA6	UBA6	UBA6	4062	0.1	0.11	YES
18	UBE2A	UBE2A	UBE2A	4198	0.098	0.11	YES
19	CUL4B	CUL4B	CUL4B	4248	0.097	0.12	YES
20	CUL4A	CUL4A	CUL4A	4256	0.096	0.13	YES
21	RCHY1	RCHY1	RCHY1	4286	0.096	0.14	YES
22	SAE1	SAE1	SAE1	4287	0.096	0.15	YES
23	UBE2B	UBE2B	UBE2B	4357	0.094	0.16	YES
24	CDC20	CDC20	CDC20	4406	0.093	0.16	YES
25	NEDD4L	NEDD4L	NEDD4L	4644	0.088	0.16	YES
26	UBE2K	UBE2K	UBE2K	4683	0.087	0.17	YES
27	UBE2H	UBE2H	UBE2H	4782	0.085	0.17	YES
28	MGRN1	MGRN1	MGRN1	4897	0.082	0.17	YES
29	UBE2D2	UBE2D2	UBE2D2	4958	0.08	0.18	YES
30	BIRC3	BIRC3	BIRC3	4968	0.08	0.18	YES
31	SKP1	SKP1	SKP1	5111	0.077	0.19	YES
32	RHOBTB2	RHOBTB2	RHOBTB2	5118	0.077	0.19	YES
33	UBE2D3	UBE2D3	UBE2D3	5150	0.076	0.2	YES
34	FZR1	FZR1	FZR1	5162	0.076	0.21	YES
35	SMURF1	SMURF1	SMURF1	5298	0.073	0.21	YES
36	ANAPC4	ANAPC4	ANAPC4	5385	0.072	0.21	YES
37	HUWE1	HUWE1	HUWE1	5476	0.07	0.21	YES
38	UBOX5	UBOX5	UBOX5	5547	0.068	0.22	YES
39	FBXW8	FBXW8	FBXW8	5658	0.066	0.22	YES
40	UBE2N	UBE2N	UBE2N	5705	0.066	0.22	YES
41	FBXW11	FBXW11	FBXW11	5753	0.064	0.22	YES
42	UBE2I	UBE2I	UBE2I	5802	0.064	0.23	YES
43	TCEB2	TCEB2	TCEB2	5881	0.062	0.23	YES
44	UBE3B	UBE3B	UBE3B	5921	0.061	0.24	YES
45	UBA1	UBA1	UBA1	6011	0.06	0.24	YES
46	ANAPC5	ANAPC5	ANAPC5	6116	0.058	0.24	YES
47	UBE2S	UBE2S	UBE2S	6128	0.058	0.24	YES
48	SIAH1	SIAH1	SIAH1	6175	0.057	0.25	YES
49	FANCL	FANCL	FANCL	6189	0.056	0.25	YES
50	UBE2M	UBE2M	UBE2M	6253	0.055	0.25	YES
51	UBE2E2	UBE2E2	UBE2E2	6364	0.053	0.25	YES
52	SKP2	SKP2	SKP2	6494	0.051	0.25	YES
53	UBE3A	UBE3A	UBE3A	6580	0.05	0.25	YES
54	CUL1	CUL1	CUL1	6622	0.049	0.26	YES
55	PIAS4	PIAS4	PIAS4	6702	0.047	0.26	YES
56	SYVN1	SYVN1	SYVN1	7042	0.042	0.24	NO
57	CDC16	CDC16	CDC16	7071	0.041	0.24	NO
58	UBE2G2	UBE2G2	UBE2G2	7075	0.041	0.25	NO
59	HERC1	HERC1	HERC1	7286	0.037	0.24	NO
60	KEAP1	KEAP1	KEAP1	7425	0.035	0.24	NO
61	PPIL2	PPIL2	PPIL2	7587	0.032	0.23	NO
62	WWP2	WWP2	WWP2	7590	0.032	0.23	NO
63	ANAPC13	ANAPC13	ANAPC13	7751	0.03	0.23	NO
64	MAP3K1	MAP3K1	MAP3K1	7805	0.029	0.23	NO
65	ANAPC7	ANAPC7	ANAPC7	7837	0.028	0.23	NO
66	BIRC6	BIRC6	BIRC6	7943	0.026	0.22	NO
67	UBA2	UBA2	UBA2	7945	0.026	0.23	NO
68	MID1	MID1	MID1	8049	0.024	0.22	NO
69	UBE2R2	UBE2R2	UBE2R2	8186	0.022	0.22	NO
70	UBE4A	UBE4A	UBE4A	8276	0.02	0.22	NO
71	FBXW7	FBXW7	FBXW7	8324	0.019	0.22	NO
72	HERC2	HERC2	HERC2	8387	0.018	0.21	NO
73	STUB1	STUB1	STUB1	8412	0.018	0.22	NO
74	CUL3	CUL3	CUL3	8537	0.016	0.21	NO
75	UBE2J1	UBE2J1	UBE2J1	8833	0.011	0.19	NO
76	TCEB1	TCEB1	TCEB1	8851	0.011	0.19	NO
77	ANAPC2	ANAPC2	ANAPC2	8923	0.0096	0.19	NO
78	CDC26	CDC26	CDC26	9091	0.0067	0.18	NO
79	CUL2	CUL2	CUL2	9226	0.0044	0.18	NO
80	CDC34	CDC34	CDC34	9451	0.00056	0.16	NO
81	BRCA1	BRCA1	BRCA1	9473	0.00023	0.16	NO
82	DDB1	DDB1	DDB1	9815	-0.0048	0.14	NO
83	CUL7	CUL7	CUL7	9819	-0.0048	0.14	NO
84	RNF7	RNF7	RNF7	9941	-0.0067	0.14	NO
85	UBE2O	UBE2O	UBE2O	10175	-0.01	0.12	NO
86	UBE2W	UBE2W	UBE2W	10185	-0.011	0.12	NO
87	UBE2J2	UBE2J2	UBE2J2	10680	-0.019	0.099	NO
88	ANAPC11	ANAPC11	ANAPC11	10756	-0.02	0.097	NO
89	KLHL13	KLHL13	KLHL13	10779	-0.021	0.098	NO
90	SOCS3	SOCS3	SOCS3	10890	-0.022	0.094	NO
91	PIAS1	PIAS1	PIAS1	10909	-0.023	0.096	NO
92	UBE2F	UBE2F	UBE2F	11129	-0.026	0.086	NO
93	TRIP12	TRIP12	TRIP12	11292	-0.03	0.08	NO
94	PIAS2	PIAS2	PIAS2	11294	-0.03	0.083	NO
95	CDC27	CDC27	CDC27	11322	-0.03	0.085	NO
96	UBE2G1	UBE2G1	UBE2G1	11338	-0.03	0.087	NO
97	DET1	DET1	DET1	11345	-0.03	0.09	NO
98	CUL5	CUL5	CUL5	11395	-0.031	0.09	NO
99	UBE2Z	UBE2Z	UBE2Z	11465	-0.032	0.09	NO
100	UBE2L3	UBE2L3	UBE2L3	11525	-0.034	0.09	NO
101	UBE2Q2	UBE2Q2	UBE2Q2	11658	-0.036	0.086	NO
102	ITCH	ITCH	ITCH	11719	-0.037	0.087	NO
103	UBA3	UBA3	UBA3	11794	-0.038	0.087	NO
104	RBX1	RBX1	RBX1	11852	-0.039	0.088	NO
105	PML	PML	PML	11913	-0.041	0.089	NO
106	UBR5	UBR5	UBR5	12246	-0.047	0.075	NO
107	TRIM32	TRIM32	TRIM32	12374	-0.05	0.073	NO
108	UBE2Q1	UBE2Q1	UBE2Q1	12398	-0.051	0.077	NO
109	HERC4	HERC4	HERC4	12518	-0.053	0.076	NO
110	CBL	CBL	CBL	12732	-0.058	0.07	NO
111	TRIM37	TRIM37	TRIM37	12839	-0.06	0.071	NO
112	ANAPC1	ANAPC1	ANAPC1	12957	-0.063	0.071	NO
113	UBE2L6	UBE2L6	UBE2L6	12990	-0.064	0.076	NO
114	RFWD2	RFWD2	RFWD2	13053	-0.065	0.079	NO
115	UBE2D1	UBE2D1	UBE2D1	13112	-0.067	0.083	NO
116	TRAF6	TRAF6	TRAF6	13116	-0.067	0.09	NO
117	UBE4B	UBE4B	UBE4B	13314	-0.072	0.086	NO
118	PIAS3	PIAS3	PIAS3	13332	-0.072	0.093	NO
119	WWP1	WWP1	WWP1	13336	-0.072	0.1	NO
120	DDB2	DDB2	DDB2	13536	-0.077	0.098	NO
121	BIRC2	BIRC2	BIRC2	13606	-0.079	0.1	NO
122	PRPF19	PRPF19	PRPF19	13807	-0.084	0.1	NO
123	UBE2E3	UBE2E3	UBE2E3	13904	-0.087	0.1	NO
124	AIRE	AIRE	AIRE	14166	-0.094	0.099	NO
125	UBE2E1	UBE2E1	UBE2E1	14372	-0.1	0.098	NO
126	UBA7	UBA7	UBA7	14511	-0.1	0.1	NO
127	VHL	VHL	VHL	14675	-0.11	0.1	NO
128	MDM2	MDM2	MDM2	14696	-0.11	0.11	NO
129	CBLB	CBLB	CBLB	14868	-0.12	0.12	NO
130	FBXO2	FBXO2	FBXO2	16057	-0.18	0.069	NO
131	SMURF2	SMURF2	SMURF2	16585	-0.24	0.064	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	111	0.5	0.2	YES
2	CAMK2B	CAMK2B	CAMK2B	739	0.3	0.3	YES
3	PIK3R1	PIK3R1	PIK3R1	957	0.27	0.4	YES
4	PRKAR2B	PRKAR2B	PRKAR2B	1360	0.23	0.47	YES
5	RPS6KA5	RPS6KA5	RPS6KA5	2646	0.15	0.46	YES
6	PRKCA	PRKCA	PRKCA	2879	0.14	0.51	YES
7	PRKAR1B	PRKAR1B	PRKAR1B	4760	0.085	0.44	NO
8	CAMK2D	CAMK2D	CAMK2D	5264	0.074	0.44	NO
9	PRKACG	PRKACG	PRKACG	5796	0.064	0.44	NO
10	PRKAR2A	PRKAR2A	PRKAR2A	8427	0.018	0.29	NO
11	GNAS	GNAS	GNAS	8593	0.015	0.29	NO
12	AKT1	AKT1	AKT1	8685	0.014	0.29	NO
13	PRKACB	PRKACB	PRKACB	9213	0.0047	0.26	NO
14	RAC1	RAC1	RAC1	9464	0.00038	0.25	NO
15	SOS1	SOS1	SOS1	9786	-0.0044	0.23	NO
16	MAPK14	MAPK14	MAPK14	9830	-0.005	0.23	NO
17	MAPK3	MAPK3	MAPK3	9833	-0.005	0.24	NO
18	GRB2	GRB2	GRB2	10200	-0.011	0.22	NO
19	CAMK2G	CAMK2G	CAMK2G	10576	-0.017	0.21	NO
20	MAPK1	MAPK1	MAPK1	10708	-0.019	0.21	NO
21	RPS6KA1	RPS6KA1	RPS6KA1	11996	-0.042	0.15	NO
22	CREB1	CREB1	CREB1	12133	-0.045	0.16	NO
23	PRKAR1A	PRKAR1A	PRKAR1A	13265	-0.071	0.13	NO
24	PIK3CA	PIK3CA	PIK3CA	13737	-0.083	0.14	NO
25	CAMK2A	CAMK2A	CAMK2A	14364	-0.1	0.14	NO
26	HRAS	HRAS	HRAS	14538	-0.11	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACSM1	ACSM1	ACSM1	12	0.72	0.16	YES
2	ACSM3	ACSM3	ACSM3	55	0.57	0.28	YES
3	GAD1	GAD1	GAD1	283	0.41	0.36	YES
4	ABAT	ABAT	ABAT	619	0.32	0.41	YES
5	ACSM5	ACSM5	ACSM5	894	0.28	0.45	YES
6	L2HGDH	L2HGDH	L2HGDH	1134	0.25	0.49	YES
7	ACSM2A	ACSM2A	ACSM2A	1657	0.2	0.51	YES
8	HMGCS1	HMGCS1	HMGCS1	1673	0.2	0.55	YES
9	ALDH5A1	ALDH5A1	ALDH5A1	2338	0.16	0.55	YES
10	AACS	AACS	AACS	3292	0.12	0.52	YES
11	HMGCS2	HMGCS2	HMGCS2	3581	0.11	0.53	YES
12	HADH	HADH	HADH	3720	0.11	0.54	YES
13	OXCT1	OXCT1	OXCT1	3756	0.11	0.56	YES
14	ALDH1B1	ALDH1B1	ALDH1B1	4497	0.091	0.54	YES
15	ACAT2	ACAT2	ACAT2	4531	0.09	0.56	YES
16	AKR1B10	AKR1B10	AKR1B10	5079	0.078	0.55	YES
17	ACADS	ACADS	ACADS	5113	0.077	0.56	YES
18	PDHA1	PDHA1	PDHA1	5204	0.075	0.57	YES
19	ALDH3A2	ALDH3A2	ALDH3A2	5676	0.066	0.56	NO
20	BDH2	BDH2	BDH2	5776	0.064	0.57	NO
21	ALDH9A1	ALDH9A1	ALDH9A1	7111	0.04	0.5	NO
22	ECHS1	ECHS1	ECHS1	8106	0.024	0.45	NO
23	HMGCL	HMGCL	HMGCL	8148	0.023	0.45	NO
24	ALDH7A1	ALDH7A1	ALDH7A1	8205	0.022	0.46	NO
25	ALDH2	ALDH2	ALDH2	8376	0.018	0.45	NO
26	OXCT2	OXCT2	OXCT2	9321	0.0028	0.4	NO
27	HADHA	HADHA	HADHA	10980	-0.024	0.31	NO
28	ACAT1	ACAT1	ACAT1	13376	-0.073	0.19	NO
29	PDHB	PDHB	PDHB	14552	-0.11	0.15	NO
30	BDH1	BDH1	BDH1	15501	-0.15	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MARS2	MARS2	MARS2	1805	0.19	-0.013	YES
2	TARSL2	TARSL2	TARSL2	2707	0.14	0.0029	YES
3	RARS	RARS	RARS	3921	0.1	-0.017	YES
4	HARS2	HARS2	HARS2	4007	0.1	0.026	YES
5	HARS	HARS	HARS	4010	0.1	0.074	YES
6	VARS2	VARS2	VARS2	4044	0.1	0.12	YES
7	PSTK	PSTK	PSTK	4509	0.091	0.14	YES
8	MTFMT	MTFMT	MTFMT	4589	0.089	0.17	YES
9	LARS	LARS	LARS	4623	0.088	0.21	YES
10	GARS	GARS	GARS	4945	0.081	0.23	YES
11	SEPSECS	SEPSECS	SEPSECS	5015	0.079	0.26	YES
12	EARS2	EARS2	EARS2	5020	0.079	0.3	YES
13	YARS2	YARS2	YARS2	5667	0.066	0.3	YES
14	AARS2	AARS2	AARS2	5839	0.063	0.32	YES
15	SARS2	SARS2	SARS2	5854	0.063	0.34	YES
16	MARS	MARS	MARS	5906	0.062	0.37	YES
17	FARS2	FARS2	FARS2	5933	0.061	0.4	YES
18	VARS	VARS	VARS	6871	0.044	0.36	NO
19	FARSA	FARSA	FARSA	7482	0.034	0.35	NO
20	KARS	KARS	KARS	7637	0.031	0.35	NO
21	SARS	SARS	SARS	7723	0.03	0.36	NO
22	LARS2	LARS2	LARS2	8460	0.017	0.33	NO
23	IARS2	IARS2	IARS2	8767	0.012	0.32	NO
24	IARS	IARS	IARS	8768	0.012	0.32	NO
25	WARS	WARS	WARS	8773	0.012	0.33	NO
26	FARSB	FARSB	FARSB	8932	0.0095	0.32	NO
27	EPRS	EPRS	EPRS	9028	0.0078	0.32	NO
28	NARS	NARS	NARS	9050	0.0075	0.32	NO
29	PARS2	PARS2	PARS2	9070	0.0071	0.32	NO
30	TARS	TARS	TARS	9122	0.0062	0.32	NO
31	NARS2	NARS2	NARS2	10337	-0.013	0.26	NO
32	CARS2	CARS2	CARS2	10398	-0.014	0.27	NO
33	DARS	DARS	DARS	10614	-0.018	0.26	NO
34	DARS2	DARS2	DARS2	11100	-0.026	0.25	NO
35	YARS	YARS	YARS	11330	-0.03	0.25	NO
36	RARS2	RARS2	RARS2	11974	-0.042	0.23	NO
37	AARS	AARS	AARS	11990	-0.042	0.25	NO
38	CARS	CARS	CARS	12010	-0.043	0.27	NO
39	WARS2	WARS2	WARS2	12108	-0.044	0.28	NO
40	QARS	QARS	QARS	13281	-0.071	0.25	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	111	0.5	0.14	YES
2	SOCS1	SOCS1	SOCS1	163	0.46	0.28	YES
3	GHR	GHR	GHR	352	0.38	0.38	YES
4	PIK3R1	PIK3R1	PIK3R1	957	0.27	0.43	YES
5	HNF1A	HNF1A	HNF1A	2333	0.16	0.4	NO
6	PRKCA	PRKCA	PRKCA	2879	0.14	0.41	NO
7	MAP2K1	MAP2K1	MAP2K1	4819	0.084	0.32	NO
8	INSR	INSR	INSR	6005	0.06	0.28	NO
9	JAK2	JAK2	JAK2	8743	0.013	0.12	NO
10	SRF	SRF	SRF	9318	0.0029	0.094	NO
11	SOS1	SOS1	SOS1	9786	-0.0044	0.069	NO
12	MAPK3	MAPK3	MAPK3	9833	-0.005	0.068	NO
13	GRB2	GRB2	GRB2	10200	-0.011	0.05	NO
14	IRS1	IRS1	IRS1	10525	-0.016	0.037	NO
15	MAPK1	MAPK1	MAPK1	10708	-0.019	0.032	NO
16	STAT5B	STAT5B	STAT5B	11160	-0.027	0.015	NO
17	RAF1	RAF1	RAF1	11552	-0.034	0.0032	NO
18	RPS6KA1	RPS6KA1	RPS6KA1	11996	-0.042	-0.0092	NO
19	SHC1	SHC1	SHC1	12134	-0.045	-0.0034	NO
20	STAT5A	STAT5A	STAT5A	12798	-0.059	-0.023	NO
21	PTPN6	PTPN6	PTPN6	13285	-0.071	-0.029	NO
22	PLCG1	PLCG1	PLCG1	13290	-0.071	-0.0082	NO
23	PIK3CA	PIK3CA	PIK3CA	13737	-0.083	-0.0086	NO
24	GH1	GH1	GH1	16502	-0.22	-0.098	NO
25	PIK3CG	PIK3CG	PIK3CG	16917	-0.28	-0.039	NO
26	SLC2A4	SLC2A4	SLC2A4	16948	-0.28	0.044	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CYP19A1	CYP19A1	CYP19A1	28	0.63	0.083	YES
2	CYP17A1	CYP17A1	CYP17A1	219	0.44	0.13	YES
3	AKR1D1	AKR1D1	AKR1D1	279	0.41	0.18	YES
4	CYP3A5	CYP3A5	CYP3A5	409	0.37	0.23	YES
5	CYP11A1	CYP11A1	CYP11A1	733	0.3	0.25	YES
6	STS	STS	STS	943	0.27	0.27	YES
7	CYP3A43	CYP3A43	CYP3A43	1027	0.26	0.3	YES
8	SRD5A2	SRD5A2	SRD5A2	1221	0.24	0.32	YES
9	CYP3A7	CYP3A7	CYP3A7	1432	0.22	0.34	YES
10	SRD5A1	SRD5A1	SRD5A1	1595	0.2	0.36	YES
11	HSD17B6	HSD17B6	HSD17B6	1675	0.2	0.38	YES
12	AKR1C3	AKR1C3	AKR1C3	1691	0.2	0.41	YES
13	SULT1E1	SULT1E1	SULT1E1	1773	0.19	0.43	YES
14	AKR1C1	AKR1C1	AKR1C1	1923	0.18	0.45	YES
15	CYP7B1	CYP7B1	CYP7B1	1968	0.18	0.47	YES
16	CYP21A2	CYP21A2	CYP21A2	2022	0.18	0.49	YES
17	UGT2A1	UGT2A1	UGT2A1	2055	0.18	0.51	YES
18	CYP1A1	CYP1A1	CYP1A1	2123	0.17	0.53	YES
19	HSD17B3	HSD17B3	HSD17B3	2245	0.16	0.55	YES
20	UGT1A7	UGT1A7	UGT1A7	2574	0.15	0.55	YES
21	HSD3B2	HSD3B2	HSD3B2	2630	0.15	0.56	YES
22	HSD3B1	HSD3B1	HSD3B1	2970	0.13	0.56	NO
23	UGT2A3	UGT2A3	UGT2A3	3396	0.12	0.56	NO
24	CYP7A1	CYP7A1	CYP7A1	4493	0.091	0.5	NO
25	UGT1A6	UGT1A6	UGT1A6	5349	0.072	0.47	NO
26	AKR1C2	AKR1C2	AKR1C2	6556	0.05	0.4	NO
27	SRD5A3	SRD5A3	SRD5A3	7068	0.041	0.38	NO
28	HSD17B7	HSD17B7	HSD17B7	8296	0.02	0.32	NO
29	UGT2B4	UGT2B4	UGT2B4	8696	0.013	0.29	NO
30	CYP11B1	CYP11B1	CYP11B1	9734	-0.0036	0.24	NO
31	COMT	COMT	COMT	10863	-0.022	0.18	NO
32	HSD17B8	HSD17B8	HSD17B8	13093	-0.066	0.058	NO
33	CYP11B2	CYP11B2	CYP11B2	13519	-0.077	0.044	NO
34	HSD17B12	HSD17B12	HSD17B12	14160	-0.094	0.02	NO
35	CYP1B1	CYP1B1	CYP1B1	15350	-0.14	-0.028	NO
36	SULT2B1	SULT2B1	SULT2B1	15572	-0.15	-0.02	NO
37	HSD17B2	HSD17B2	HSD17B2	15610	-0.16	-0.00094	NO
38	HSD11B2	HSD11B2	HSD11B2	15641	-0.16	0.018	NO
39	UGT1A9	UGT1A9	UGT1A9	16195	-0.19	0.013	NO
40	HSD17B1	HSD17B1	HSD17B1	16858	-0.27	0.012	NO
41	HSD11B1	HSD11B1	HSD11B1	16898	-0.27	0.046	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLR2J2	POLR2J2	POLR2J2	1346	0.23	0.048	YES
2	POLR3G	POLR3G	POLR3G	1575	0.21	0.15	YES
3	POLR1E	POLR1E	POLR1E	2798	0.14	0.16	YES
4	ZNRD1	ZNRD1	ZNRD1	2976	0.13	0.22	YES
5	POLR2J3	POLR2J3	POLR2J3	3204	0.12	0.28	YES
6	POLR3B	POLR3B	POLR3B	3646	0.11	0.31	YES
7	POLR2B	POLR2B	POLR2B	5090	0.078	0.27	YES
8	POLR2J	POLR2J	POLR2J	5405	0.071	0.29	YES
9	POLR3K	POLR3K	POLR3K	5503	0.069	0.33	YES
10	POLR2C	POLR2C	POLR2C	5999	0.06	0.33	YES
11	POLR2F	POLR2F	POLR2F	6160	0.057	0.35	YES
12	POLR2I	POLR2I	POLR2I	6677	0.048	0.35	NO
13	POLR1C	POLR1C	POLR1C	7939	0.026	0.29	NO
14	POLR3D	POLR3D	POLR3D	8596	0.015	0.26	NO
15	POLR2E	POLR2E	POLR2E	8895	0.01	0.25	NO
16	POLR1D	POLR1D	POLR1D	9146	0.0058	0.24	NO
17	POLR2K	POLR2K	POLR2K	9164	0.0056	0.24	NO
18	POLR2D	POLR2D	POLR2D	9879	-0.0058	0.21	NO
19	POLR2A	POLR2A	POLR2A	9934	-0.0066	0.21	NO
20	POLR3F	POLR3F	POLR3F	10504	-0.016	0.18	NO
21	POLR2L	POLR2L	POLR2L	10520	-0.016	0.19	NO
22	POLR3A	POLR3A	POLR3A	11007	-0.024	0.18	NO
23	POLR1B	POLR1B	POLR1B	11946	-0.041	0.15	NO
24	POLR1A	POLR1A	POLR1A	11984	-0.042	0.17	NO
25	POLR3GL	POLR3GL	POLR3GL	12519	-0.053	0.17	NO
26	POLR3H	POLR3H	POLR3H	12943	-0.063	0.18	NO
27	POLR2G	POLR2G	POLR2G	13561	-0.078	0.19	NO
28	POLR3C	POLR3C	POLR3C	13940	-0.088	0.21	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	111	0.5	0.14	YES
2	EGF	EGF	EGF	156	0.46	0.27	YES
3	EGFR	EGFR	EGFR	526	0.34	0.35	YES
4	PIK3R1	PIK3R1	PIK3R1	957	0.27	0.41	YES
5	RASA1	RASA1	RASA1	1280	0.23	0.46	YES
6	ELK1	ELK1	ELK1	2631	0.15	0.42	NO
7	PRKCA	PRKCA	PRKCA	2879	0.14	0.45	NO
8	MAPK8	MAPK8	MAPK8	3572	0.11	0.44	NO
9	MAP2K1	MAP2K1	MAP2K1	4819	0.084	0.4	NO
10	STAT6	STAT6	STAT6	5495	0.07	0.38	NO
11	JAK1	JAK1	JAK1	7313	0.037	0.29	NO
12	MAP3K1	MAP3K1	MAP3K1	7805	0.029	0.27	NO
13	CSNK2A1	CSNK2A1	CSNK2A1	8436	0.018	0.24	NO
14	STAT3	STAT3	STAT3	8680	0.014	0.23	NO
15	JUN	JUN	JUN	8887	0.01	0.22	NO
16	SRF	SRF	SRF	9318	0.0029	0.2	NO
17	SOS1	SOS1	SOS1	9786	-0.0044	0.17	NO
18	MAPK3	MAPK3	MAPK3	9833	-0.005	0.17	NO
19	GRB2	GRB2	GRB2	10200	-0.011	0.15	NO
20	MAP2K4	MAP2K4	MAP2K4	10579	-0.017	0.14	NO
21	STAT5B	STAT5B	STAT5B	11160	-0.027	0.11	NO
22	RAF1	RAF1	RAF1	11552	-0.034	0.1	NO
23	SHC1	SHC1	SHC1	12134	-0.045	0.081	NO
24	STAT5A	STAT5A	STAT5A	12798	-0.059	0.061	NO
25	PLCG1	PLCG1	PLCG1	13290	-0.071	0.054	NO
26	STAT2	STAT2	STAT2	13334	-0.072	0.073	NO
27	PIK3CA	PIK3CA	PIK3CA	13737	-0.083	0.075	NO
28	STAT1	STAT1	STAT1	14123	-0.093	0.08	NO
29	FOS	FOS	FOS	14794	-0.12	0.076	NO
30	STAT4	STAT4	STAT4	17116	-0.3	0.034	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CES7	CES7	CES7	2	0.89	0.16	YES
2	UPP2	UPP2	UPP2	317	0.4	0.21	YES
3	CYP3A5	CYP3A5	CYP3A5	409	0.37	0.27	YES
4	CYP2A6	CYP2A6	CYP2A6	567	0.33	0.32	YES
5	CYP3A43	CYP3A43	CYP3A43	1027	0.26	0.34	YES
6	CYP2A7	CYP2A7	CYP2A7	1063	0.26	0.39	YES
7	CYP3A7	CYP3A7	CYP3A7	1432	0.22	0.41	YES
8	XDH	XDH	XDH	1503	0.21	0.44	YES
9	UGT2A1	UGT2A1	UGT2A1	2055	0.18	0.44	YES
10	DPYD	DPYD	DPYD	2348	0.16	0.45	YES
11	HPRT1	HPRT1	HPRT1	2497	0.15	0.47	YES
12	UGT1A7	UGT1A7	UGT1A7	2574	0.15	0.5	YES
13	TPMT	TPMT	TPMT	2717	0.14	0.51	YES
14	DPYS	DPYS	DPYS	3240	0.12	0.5	YES
15	UGT2A3	UGT2A3	UGT2A3	3396	0.12	0.52	YES
16	NAT1	NAT1	NAT1	3771	0.11	0.52	YES
17	CES2	CES2	CES2	3939	0.1	0.52	YES
18	UPP1	UPP1	UPP1	4988	0.08	0.48	NO
19	UGT1A6	UGT1A6	UGT1A6	5349	0.072	0.47	NO
20	GUSB	GUSB	GUSB	5577	0.068	0.47	NO
21	NAT2	NAT2	NAT2	8198	0.022	0.33	NO
22	CDA	CDA	CDA	8317	0.02	0.32	NO
23	TK1	TK1	TK1	8347	0.019	0.33	NO
24	UGT2B4	UGT2B4	UGT2B4	8696	0.013	0.31	NO
25	ITPA	ITPA	ITPA	8705	0.013	0.31	NO
26	TK2	TK2	TK2	8795	0.012	0.31	NO
27	CES1	CES1	CES1	9144	0.0058	0.29	NO
28	UCK1	UCK1	UCK1	10124	-0.0096	0.24	NO
29	UPB1	UPB1	UPB1	10883	-0.022	0.2	NO
30	UMPS	UMPS	UMPS	11419	-0.032	0.17	NO
31	UCKL1	UCKL1	UCKL1	12595	-0.055	0.12	NO
32	IMPDH2	IMPDH2	IMPDH2	14616	-0.11	0.021	NO
33	UCK2	UCK2	UCK2	14993	-0.12	0.022	NO
34	GMPS	GMPS	GMPS	15308	-0.14	0.029	NO
35	IMPDH1	IMPDH1	IMPDH1	15843	-0.17	0.029	NO
36	UGT1A9	UGT1A9	UGT1A9	16195	-0.19	0.044	NO
37	TYMP	TYMP	TYMP	16598	-0.24	0.063	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA BIOPEPTIDES PATHWAY	38	genes.ES.table	0.45	1.5	0.056	0.2	0.87	0.24	0.19	0.19	0.15	0.004
BIOCARTA CARM ER PATHWAY	34	genes.ES.table	0.41	1.5	0.054	0.21	0.85	0.12	0.07	0.11	0.15	0.011
BIOCARTA HDAC PATHWAY	26	genes.ES.table	0.55	1.7	0.004	0.5	0.47	0.27	0.18	0.22	0	0.18
BIOCARTA EGF PATHWAY	30	genes.ES.table	0.53	1.6	0.039	0.32	0.77	0.47	0.29	0.33	0.21	0.058
BIOCARTA FCER1 PATHWAY	37	genes.ES.table	0.53	1.5	0.067	0.21	0.84	0.27	0.12	0.24	0.15	0.013
BIOCARTA GH PATHWAY	26	genes.ES.table	0.47	1.5	0.04	0.2	0.86	0.19	0.094	0.18	0.15	0.005
BIOCARTA IL2RB PATHWAY	37	genes.ES.table	0.72	1.9	0.002	0.18	0.089	0.35	0.097	0.32	0	0.072
BIOCARTA GSK3 PATHWAY	26	genes.ES.table	0.51	1.6	0.021	0.36	0.73	0.19	0.12	0.17	0.23	0.08
BIOCARTA DEATH PATHWAY	32	genes.ES.table	0.44	1.4	0.1	0.21	0.91	0.41	0.29	0.29	0.16	0.001
BIOCARTA KERATINOCYTE PATHWAY	45	genes.ES.table	0.44	1.4	0.1	0.24	0.94	0.49	0.28	0.35	0.2	0.004

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL2RB	IL2RB	IL2RB	31	0.88	0.11	YES
2	FASLG	FASLG	FASLG	138	0.68	0.19	YES
3	PIK3CG	PIK3CG	PIK3CG	163	0.66	0.27	YES
4	IL2RG	IL2RG	IL2RG	202	0.64	0.35	YES
5	IL2RA	IL2RA	IL2RA	336	0.58	0.41	YES
6	IKZF3	IKZF3	IKZF3	395	0.55	0.48	YES
7	SYK	SYK	SYK	545	0.5	0.53	YES
8	JAK3	JAK3	JAK3	794	0.44	0.58	YES
9	BCL2	BCL2	BCL2	1394	0.33	0.58	YES
10	PTPN6	PTPN6	PTPN6	1559	0.31	0.61	YES
11	STAT5A	STAT5A	STAT5A	1627	0.3	0.65	YES
12	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.68	YES
13	FAS	FAS	FAS	1721	0.29	0.72	YES
14	STAT5B	STAT5B	STAT5B	2744	0.2	0.68	NO
15	MAPK3	MAPK3	MAPK3	4472	0.11	0.6	NO
16	JAK1	JAK1	JAK1	4779	0.097	0.6	NO
17	FOS	FOS	FOS	6045	0.06	0.53	NO
18	CFLAR	CFLAR	CFLAR	6344	0.052	0.52	NO
19	SOS1	SOS1	SOS1	6990	0.037	0.49	NO
20	BAD	BAD	BAD	7089	0.034	0.49	NO
21	RPS6KB1	RPS6KB1	RPS6KB1	7186	0.032	0.49	NO
22	BCL2L1	BCL2L1	BCL2L1	7288	0.03	0.48	NO
23	SOCS3	SOCS3	SOCS3	7444	0.027	0.48	NO
24	GRB2	GRB2	GRB2	8173	0.012	0.44	NO
25	RAF1	RAF1	RAF1	8205	0.012	0.44	NO
26	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.43	NO
27	SHC1	SHC1	SHC1	8921	-0.0026	0.4	NO
28	NMI	NMI	NMI	8928	-0.0029	0.4	NO
29	AKT1	AKT1	AKT1	9017	-0.0045	0.4	NO
30	IRS1	IRS1	IRS1	10772	-0.038	0.3	NO
31	CBL	CBL	CBL	11295	-0.049	0.28	NO
32	MAPK1	MAPK1	MAPK1	11645	-0.056	0.26	NO
33	CRKL	CRKL	CRKL	11706	-0.058	0.27	NO
34	SOCS1	SOCS1	SOCS1	12933	-0.088	0.21	NO
35	PPIA	PPIA	PPIA	13454	-0.1	0.19	NO
36	HRAS	HRAS	HRAS	13470	-0.1	0.21	NO
37	MYC	MYC	MYC	16006	-0.27	0.097	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A6	UGT1A6	UGT1A6	3	1	0.12	YES
2	UGT1A9	UGT1A9	UGT1A9	16	0.92	0.23	YES
3	UGT1A7	UGT1A7	UGT1A7	45	0.82	0.32	YES
4	AMY2A	AMY2A	AMY2A	231	0.62	0.39	YES
5	AMY2B	AMY2B	AMY2B	504	0.51	0.43	YES
6	ENPP1	ENPP1	ENPP1	526	0.51	0.49	YES
7	HK2	HK2	HK2	641	0.48	0.54	YES
8	UGT2A3	UGT2A3	UGT2A3	891	0.42	0.58	YES
9	AMY1A	AMY1A	AMY1A	949	0.41	0.62	YES
10	UGT2A1	UGT2A1	UGT2A1	1083	0.38	0.66	YES
11	UGT2B4	UGT2B4	UGT2B4	2128	0.25	0.63	NO
12	GYS2	GYS2	GYS2	2244	0.24	0.65	NO
13	PYGB	PYGB	PYGB	3516	0.15	0.6	NO
14	UGDH	UGDH	UGDH	5625	0.071	0.49	NO
15	HK3	HK3	HK3	5732	0.068	0.49	NO
16	GAA	GAA	GAA	6606	0.045	0.44	NO
17	PYGL	PYGL	PYGL	6798	0.041	0.44	NO
18	AGL	AGL	AGL	7755	0.02	0.39	NO
19	GANC	GANC	GANC	7846	0.018	0.38	NO
20	UGP2	UGP2	UGP2	8066	0.014	0.37	NO
21	PGM1	PGM1	PGM1	8220	0.012	0.37	NO
22	GBE1	GBE1	GBE1	8642	0.0031	0.34	NO
23	GPI	GPI	GPI	9033	-0.0046	0.32	NO
24	GYS1	GYS1	GYS1	10842	-0.04	0.22	NO
25	PGM2	PGM2	PGM2	11103	-0.045	0.22	NO
26	MGAM	MGAM	MGAM	12063	-0.066	0.17	NO
27	HK1	HK1	HK1	13339	-0.1	0.11	NO
28	PYGM	PYGM	PYGM	13419	-0.1	0.12	NO
29	GUSB	GUSB	GUSB	13561	-0.11	0.12	NO
30	G6PC2	G6PC2	G6PC2	14535	-0.15	0.083	NO
31	GBA3	GBA3	GBA3	14730	-0.16	0.091	NO
32	GCK	GCK	GCK	15429	-0.21	0.076	NO
33	PGM2L1	PGM2L1	PGM2L1	15507	-0.22	0.097	NO
34	ENPP3	ENPP3	ENPP3	15716	-0.24	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IGF1	IGF1	IGF1	95	0.72	0.19	YES
2	PIK3CG	PIK3CG	PIK3CG	163	0.66	0.36	YES
3	MAP2K6	MAP2K6	MAP2K6	1006	0.4	0.42	YES
4	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.47	YES
5	NFATC2	NFATC2	NFATC2	2108	0.25	0.51	YES
6	HDAC5	HDAC5	HDAC5	2984	0.18	0.51	YES
7	CAMK1G	CAMK1G	CAMK1G	3168	0.17	0.55	YES
8	NFATC1	NFATC1	NFATC1	4772	0.097	0.48	NO
9	IGF1R	IGF1R	IGF1R	6025	0.06	0.43	NO
10	PPP3CA	PPP3CA	PPP3CA	6175	0.056	0.44	NO
11	PPP3CC	PPP3CC	PPP3CC	7429	0.027	0.37	NO
12	MEF2A	MEF2A	MEF2A	7868	0.018	0.35	NO
13	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.32	NO
14	MAPK7	MAPK7	MAPK7	8375	0.0082	0.33	NO
15	AKT1	AKT1	AKT1	9017	-0.0045	0.29	NO
16	CABIN1	CABIN1	CABIN1	9655	-0.016	0.26	NO
17	PPP3CB	PPP3CB	PPP3CB	10164	-0.026	0.24	NO
18	CALM1	CALM1	CALM1	10276	-0.029	0.24	NO
19	MEF2D	MEF2D	MEF2D	10534	-0.034	0.24	NO
20	CAMK1	CAMK1	CAMK1	11781	-0.06	0.18	NO
21	INSR	INSR	INSR	12175	-0.069	0.18	NO
22	YWHAH	YWHAH	YWHAH	12597	-0.079	0.18	NO
23	CALM3	CALM3	CALM3	12638	-0.08	0.19	NO
24	CALM2	CALM2	CALM2	12956	-0.089	0.2	NO
25	MAPK14	MAPK14	MAPK14	13897	-0.12	0.18	NO
26	LOC729991-MEF2B	LOC729991-MEF2B	LOC729991-MEF2B	14241	-0.14	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	STAT4	STAT4	STAT4	122	0.7	0.16	YES
2	PIK3CG	PIK3CG	PIK3CG	163	0.66	0.31	YES
3	PRKCA	PRKCA	PRKCA	301	0.59	0.44	YES
4	STAT5A	STAT5A	STAT5A	1627	0.3	0.43	YES
5	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.5	YES
6	STAT5B	STAT5B	STAT5B	2744	0.2	0.49	YES
7	STAT6	STAT6	STAT6	3336	0.16	0.49	YES
8	MAPK3	MAPK3	MAPK3	4472	0.11	0.45	YES
9	MAP3K1	MAP3K1	MAP3K1	4767	0.097	0.46	YES
10	MAP2K4	MAP2K4	MAP2K4	4774	0.097	0.48	YES
11	JAK1	JAK1	JAK1	4779	0.097	0.5	YES
12	JUN	JUN	JUN	4911	0.093	0.52	YES
13	STAT2	STAT2	STAT2	4938	0.091	0.54	YES
14	STAT3	STAT3	STAT3	5143	0.085	0.55	YES
15	CSNK2A1	CSNK2A1	CSNK2A1	5932	0.062	0.52	NO
16	RASA1	RASA1	RASA1	5938	0.062	0.53	NO
17	FOS	FOS	FOS	6045	0.06	0.54	NO
18	PRKCB	PRKCB	PRKCB	6978	0.037	0.5	NO
19	SOS1	SOS1	SOS1	6990	0.037	0.5	NO
20	PDGFRA	PDGFRA	PDGFRA	8054	0.014	0.45	NO
21	PLCG1	PLCG1	PLCG1	8085	0.014	0.45	NO
22	GRB2	GRB2	GRB2	8173	0.012	0.45	NO
23	RAF1	RAF1	RAF1	8205	0.012	0.45	NO
24	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.44	NO
25	SHC1	SHC1	SHC1	8921	-0.0026	0.41	NO
26	SRF	SRF	SRF	9251	-0.0085	0.39	NO
27	STAT1	STAT1	STAT1	9907	-0.022	0.36	NO
28	PDGFA	PDGFA	PDGFA	11262	-0.048	0.3	NO
29	MAP2K1	MAP2K1	MAP2K1	12405	-0.074	0.25	NO
30	ELK1	ELK1	ELK1	12692	-0.081	0.25	NO
31	MAPK8	MAPK8	MAPK8	14381	-0.14	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ITK	ITK	ITK	27	0.89	0.037	YES
2	CD247	CD247	CD247	62	0.78	0.07	YES
3	CD3E	CD3E	CD3E	64	0.78	0.1	YES
4	PTPRC	PTPRC	PTPRC	116	0.7	0.13	YES
5	CD40LG	CD40LG	CD40LG	142	0.68	0.16	YES
6	GRAP2	GRAP2	GRAP2	158	0.67	0.19	YES
7	PIK3CG	PIK3CG	PIK3CG	163	0.66	0.22	YES
8	CD28	CD28	CD28	183	0.65	0.24	YES
9	CD3G	CD3G	CD3G	213	0.64	0.27	YES
10	CD8B	CD8B	CD8B	242	0.62	0.3	YES
11	CD3D	CD3D	CD3D	265	0.6	0.32	YES
12	CD8A	CD8A	CD8A	279	0.6	0.35	YES
13	ICOS	ICOS	ICOS	306	0.59	0.37	YES
14	ZAP70	ZAP70	ZAP70	308	0.59	0.4	YES
15	VAV3	VAV3	VAV3	322	0.58	0.42	YES
16	CD4	CD4	CD4	328	0.58	0.45	YES
17	LCK	LCK	LCK	342	0.57	0.47	YES
18	LCP2	LCP2	LCP2	360	0.56	0.49	YES
19	PIK3CD	PIK3CD	PIK3CD	513	0.51	0.51	YES
20	VAV1	VAV1	VAV1	889	0.42	0.5	YES
21	CTLA4	CTLA4	CTLA4	961	0.41	0.52	YES
22	PDCD1	PDCD1	PDCD1	1042	0.39	0.53	YES
23	TNF	TNF	TNF	1337	0.34	0.53	YES
24	MAP3K8	MAP3K8	MAP3K8	1551	0.31	0.53	YES
25	PTPN6	PTPN6	PTPN6	1559	0.31	0.55	YES
26	LAT	LAT	LAT	1652	0.3	0.55	YES
27	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.57	YES
28	RASGRP1	RASGRP1	RASGRP1	1814	0.28	0.57	YES
29	PIK3R5	PIK3R5	PIK3R5	1998	0.26	0.57	YES
30	CARD11	CARD11	CARD11	2060	0.25	0.58	YES
31	NFATC2	NFATC2	NFATC2	2108	0.25	0.59	YES
32	IL10	IL10	IL10	2438	0.22	0.58	NO
33	CSF2	CSF2	CSF2	2535	0.22	0.58	NO
34	IKBKB	IKBKB	IKBKB	2693	0.21	0.58	NO
35	PAK7	PAK7	PAK7	2877	0.19	0.58	NO
36	AKT3	AKT3	AKT3	3103	0.18	0.57	NO
37	PIK3CB	PIK3CB	PIK3CB	3429	0.16	0.56	NO
38	IFNG	IFNG	IFNG	3532	0.15	0.56	NO
39	NFATC3	NFATC3	NFATC3	3724	0.14	0.56	NO
40	MAP3K14	MAP3K14	MAP3K14	3921	0.13	0.55	NO
41	FYN	FYN	FYN	4175	0.12	0.55	NO
42	MAPK3	MAPK3	MAPK3	4472	0.11	0.53	NO
43	PIK3R2	PIK3R2	PIK3R2	4715	0.099	0.52	NO
44	NFATC1	NFATC1	NFATC1	4772	0.097	0.52	NO
45	NFKBIA	NFKBIA	NFKBIA	4886	0.094	0.52	NO
46	JUN	JUN	JUN	4911	0.093	0.52	NO
47	NFKB1	NFKB1	NFKB1	4945	0.091	0.53	NO
48	DLG1	DLG1	DLG1	4994	0.089	0.53	NO
49	NCK1	NCK1	NCK1	5107	0.086	0.52	NO
50	NFAT5	NFAT5	NFAT5	5187	0.084	0.52	NO
51	MAPK9	MAPK9	MAPK9	5210	0.083	0.53	NO
52	PAK3	PAK3	PAK3	5469	0.075	0.52	NO
53	MALT1	MALT1	MALT1	5924	0.062	0.49	NO
54	FOS	FOS	FOS	6045	0.06	0.49	NO
55	PPP3CA	PPP3CA	PPP3CA	6175	0.056	0.48	NO
56	NFKBIE	NFKBIE	NFKBIE	6237	0.054	0.48	NO
57	PAK1	PAK1	PAK1	6317	0.053	0.48	NO
58	CDK4	CDK4	CDK4	6373	0.051	0.48	NO
59	NCK2	NCK2	NCK2	6388	0.051	0.48	NO
60	CBLB	CBLB	CBLB	6956	0.038	0.45	NO
61	SOS1	SOS1	SOS1	6990	0.037	0.45	NO
62	PPP3CC	PPP3CC	PPP3CC	7429	0.027	0.43	NO
63	IKBKG	IKBKG	IKBKG	7452	0.026	0.43	NO
64	TEC	TEC	TEC	7695	0.022	0.41	NO
65	PAK2	PAK2	PAK2	7769	0.02	0.41	NO
66	PLCG1	PLCG1	PLCG1	8085	0.014	0.39	NO
67	GRB2	GRB2	GRB2	8173	0.012	0.39	NO
68	PIK3R3	PIK3R3	PIK3R3	8181	0.012	0.39	NO
69	RAF1	RAF1	RAF1	8205	0.012	0.39	NO
70	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.38	NO
71	RELA	RELA	RELA	8802	-0.00044	0.35	NO
72	SOS2	SOS2	SOS2	8805	-0.00059	0.35	NO
73	GSK3B	GSK3B	GSK3B	9003	-0.0042	0.34	NO
74	AKT1	AKT1	AKT1	9017	-0.0045	0.34	NO
75	RHOA	RHOA	RHOA	9240	-0.0083	0.33	NO
76	CHP2	CHP2	CHP2	9457	-0.013	0.32	NO
77	MAPK13	MAPK13	MAPK13	9640	-0.016	0.31	NO
78	MAP3K7	MAP3K7	MAP3K7	9753	-0.019	0.3	NO
79	MAP2K2	MAP2K2	MAP2K2	10117	-0.026	0.28	NO
80	PPP3CB	PPP3CB	PPP3CB	10164	-0.026	0.28	NO
81	NFKBIB	NFKBIB	NFKBIB	10189	-0.027	0.28	NO
82	CDC42	CDC42	CDC42	10489	-0.033	0.27	NO
83	BCL10	BCL10	BCL10	10492	-0.033	0.27	NO
84	PRKCQ	PRKCQ	PRKCQ	10545	-0.034	0.27	NO
85	PPP3R1	PPP3R1	PPP3R1	10684	-0.037	0.26	NO
86	MAP2K7	MAP2K7	MAP2K7	11117	-0.045	0.24	NO
87	CBL	CBL	CBL	11295	-0.049	0.23	NO
88	MAPK1	MAPK1	MAPK1	11645	-0.056	0.21	NO
89	CHUK	CHUK	CHUK	12387	-0.074	0.17	NO
90	MAP2K1	MAP2K1	MAP2K1	12405	-0.074	0.18	NO
91	NRAS	NRAS	NRAS	12488	-0.076	0.18	NO
92	KRAS	KRAS	KRAS	13044	-0.091	0.15	NO
93	MAPK11	MAPK11	MAPK11	13383	-0.1	0.13	NO
94	CHP	CHP	CHP	13741	-0.12	0.12	NO
95	MAPK14	MAPK14	MAPK14	13897	-0.12	0.11	NO
96	AKT2	AKT2	AKT2	14564	-0.15	0.083	NO
97	PAK4	PAK4	PAK4	14674	-0.16	0.084	NO
98	PDK1	PDK1	PDK1	15910	-0.26	0.025	NO
99	VAV2	VAV2	VAV2	16082	-0.28	0.027	NO
100	MAPK12	MAPK12	MAPK12	16616	-0.35	0.012	NO
101	PAK6	PAK6	PAK6	16712	-0.37	0.023	NO
102	NFATC4	NFATC4	NFATC4	17665	-0.77	0.003	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HLA-DRB5	HLA-DRB5	HLA-DRB5	174	0.66	0.031	YES
2	HLA-DQA1	HLA-DQA1	HLA-DQA1	206	0.64	0.07	YES
3	HLA-DOA	HLA-DOA	HLA-DOA	221	0.63	0.11	YES
4	CD8B	CD8B	CD8B	242	0.62	0.15	YES
5	CD8A	CD8A	CD8A	279	0.6	0.18	YES
6	HLA-DQA2	HLA-DQA2	HLA-DQA2	284	0.6	0.22	YES
7	KLRD1	KLRD1	KLRD1	303	0.59	0.25	YES
8	CD4	CD4	CD4	328	0.58	0.29	YES
9	HLA-DQB1	HLA-DQB1	HLA-DQB1	455	0.53	0.31	YES
10	CTSS	CTSS	CTSS	562	0.5	0.34	YES
11	HLA-DRB1	HLA-DRB1	HLA-DRB1	584	0.49	0.37	YES
12	CIITA	CIITA	CIITA	598	0.49	0.4	YES
13	HLA-DPA1	HLA-DPA1	HLA-DPA1	666	0.47	0.42	YES
14	IFI30	IFI30	IFI30	795	0.44	0.44	YES
15	HLA-DPB1	HLA-DPB1	HLA-DPB1	865	0.43	0.47	YES
16	LTA	LTA	LTA	931	0.42	0.49	YES
17	HLA-DOB	HLA-DOB	HLA-DOB	939	0.41	0.51	YES
18	KIR2DS4	KIR2DS4	KIR2DS4	1052	0.39	0.53	YES
19	HLA-DRA	HLA-DRA	HLA-DRA	1065	0.39	0.56	YES
20	HLA-F	HLA-F	HLA-F	1179	0.37	0.57	YES
21	CD74	CD74	CD74	1207	0.36	0.59	YES
22	KIR2DL1	KIR2DL1	KIR2DL1	1230	0.36	0.62	YES
23	HLA-DMA	HLA-DMA	HLA-DMA	1492	0.32	0.62	YES
24	KIR3DL2	KIR3DL2	KIR3DL2	1493	0.32	0.64	YES
25	KIR3DL1	KIR3DL1	KIR3DL1	1778	0.28	0.64	YES
26	KLRC1	KLRC1	KLRC1	1887	0.27	0.65	YES
27	HLA-E	HLA-E	HLA-E	2286	0.24	0.64	YES
28	HLA-B	HLA-B	HLA-B	2307	0.24	0.66	YES
29	HLA-A	HLA-A	HLA-A	2371	0.23	0.67	YES
30	KLRC4	KLRC4	KLRC4	2750	0.2	0.66	YES
31	KIR2DL3	KIR2DL3	KIR2DL3	2806	0.2	0.67	YES
32	HLA-C	HLA-C	HLA-C	3011	0.18	0.67	YES
33	B2M	B2M	B2M	3070	0.18	0.68	YES
34	HLA-DMB	HLA-DMB	HLA-DMB	3348	0.16	0.67	YES
35	HLA-G	HLA-G	HLA-G	3427	0.16	0.68	YES
36	NFYB	NFYB	NFYB	3496	0.15	0.68	YES
37	CTSB	CTSB	CTSB	3624	0.15	0.68	YES
38	KLRC3	KLRC3	KLRC3	3992	0.13	0.67	NO
39	HSPA2	HSPA2	HSPA2	4193	0.12	0.67	NO
40	TAPBP	TAPBP	TAPBP	4406	0.11	0.66	NO
41	KIR2DL4	KIR2DL4	KIR2DL4	4593	0.1	0.66	NO
42	HSPA1L	HSPA1L	HSPA1L	4771	0.097	0.66	NO
43	RFXAP	RFXAP	RFXAP	5477	0.074	0.62	NO
44	TAP1	TAP1	TAP1	5513	0.073	0.62	NO
45	CTSL1	CTSL1	CTSL1	5530	0.073	0.63	NO
46	CANX	CANX	CANX	5899	0.063	0.61	NO
47	CREB1	CREB1	CREB1	6212	0.055	0.6	NO
48	CALR	CALR	CALR	6865	0.04	0.56	NO
49	HSP90AA1	HSP90AA1	HSP90AA1	7417	0.027	0.53	NO
50	LGMN	LGMN	LGMN	7582	0.024	0.52	NO
51	PDIA3	PDIA3	PDIA3	7817	0.019	0.51	NO
52	PSME3	PSME3	PSME3	7960	0.016	0.5	NO
53	KLRC2	KLRC2	KLRC2	8097	0.014	0.5	NO
54	HSPA6	HSPA6	HSPA6	9274	-0.0089	0.43	NO
55	HSPA4	HSPA4	HSPA4	9495	-0.013	0.42	NO
56	HSPA1B	HSPA1B	HSPA1B	9606	-0.016	0.41	NO
57	NFYC	NFYC	NFYC	9673	-0.017	0.41	NO
58	TAP2	TAP2	TAP2	9733	-0.018	0.41	NO
59	PSME1	PSME1	PSME1	10393	-0.031	0.37	NO
60	HSPA5	HSPA5	HSPA5	11030	-0.043	0.34	NO
61	HSPA8	HSPA8	HSPA8	11936	-0.063	0.29	NO
62	HSPA1A	HSPA1A	HSPA1A	12428	-0.075	0.27	NO
63	NFYA	NFYA	NFYA	12476	-0.076	0.27	NO
64	RFX5	RFX5	RFX5	13276	-0.098	0.23	NO
65	RFXANK	RFXANK	RFXANK	13869	-0.12	0.21	NO
66	PSME2	PSME2	PSME2	14962	-0.17	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCL5	CCL5	CCL5	119	0.7	0.09	YES
2	CASP1	CASP1	CASP1	152	0.67	0.18	YES
3	IL33	IL33	IL33	345	0.57	0.25	YES
4	PYCARD	PYCARD	PYCARD	390	0.55	0.32	YES
5	IKBKE	IKBKE	IKBKE	446	0.53	0.39	YES
6	RIPK3	RIPK3	RIPK3	797	0.44	0.43	YES
7	ZBP1	ZBP1	ZBP1	953	0.41	0.48	YES
8	CXCL10	CXCL10	CXCL10	989	0.4	0.54	YES
9	CCL4	CCL4	CCL4	1800	0.28	0.53	YES
10	IL18	IL18	IL18	1807	0.28	0.57	YES
11	TMEM173	TMEM173	TMEM173	2136	0.25	0.58	YES
12	IL1B	IL1B	IL1B	2463	0.22	0.59	YES
13	CCL4L2	CCL4L2	CCL4L2	2532	0.22	0.62	YES
14	IRF7	IRF7	IRF7	2641	0.21	0.64	YES
15	IKBKB	IKBKB	IKBKB	2693	0.21	0.67	YES
16	DDX58	DDX58	DDX58	4224	0.12	0.6	NO
17	AIM2	AIM2	AIM2	4852	0.094	0.58	NO
18	NFKBIA	NFKBIA	NFKBIA	4886	0.094	0.59	NO
19	NFKB1	NFKB1	NFKB1	4945	0.091	0.6	NO
20	IL6	IL6	IL6	5982	0.061	0.55	NO
21	POLR3F	POLR3F	POLR3F	6125	0.057	0.55	NO
22	POLR3GL	POLR3GL	POLR3GL	6512	0.048	0.53	NO
23	POLR3G	POLR3G	POLR3G	6687	0.044	0.53	NO
24	MAVS	MAVS	MAVS	7031	0.036	0.51	NO
25	IKBKG	IKBKG	IKBKG	7452	0.026	0.49	NO
26	RIPK1	RIPK1	RIPK1	7939	0.017	0.47	NO
27	POLR3B	POLR3B	POLR3B	7952	0.016	0.47	NO
28	TBK1	TBK1	TBK1	7991	0.016	0.47	NO
29	IRF3	IRF3	IRF3	8027	0.015	0.47	NO
30	POLR3K	POLR3K	POLR3K	8624	0.0035	0.44	NO
31	RELA	RELA	RELA	8802	-0.00044	0.43	NO
32	ADAR	ADAR	ADAR	8997	-0.0042	0.42	NO
33	TREX1	TREX1	TREX1	9786	-0.019	0.37	NO
34	NFKBIB	NFKBIB	NFKBIB	10189	-0.027	0.35	NO
35	POLR3C	POLR3C	POLR3C	11210	-0.047	0.3	NO
36	POLR3D	POLR3D	POLR3D	11802	-0.06	0.28	NO
37	POLR1C	POLR1C	POLR1C	12246	-0.07	0.26	NO
38	CHUK	CHUK	CHUK	12387	-0.074	0.26	NO
39	POLR1D	POLR1D	POLR1D	12900	-0.087	0.25	NO
40	POLR3A	POLR3A	POLR3A	12904	-0.088	0.26	NO
41	POLR3H	POLR3H	POLR3H	12940	-0.089	0.27	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A6	UGT1A6	UGT1A6	3	1	0.18	YES
2	UGT1A9	UGT1A9	UGT1A9	16	0.92	0.33	YES
3	UGT1A7	UGT1A7	UGT1A7	45	0.82	0.47	YES
4	UGT2A3	UGT2A3	UGT2A3	891	0.42	0.5	YES
5	UGT2A1	UGT2A1	UGT2A1	1083	0.38	0.55	YES
6	UGT2B4	UGT2B4	UGT2B4	2128	0.25	0.53	YES
7	CP	CP	CP	2251	0.24	0.57	YES
8	BLVRB	BLVRB	BLVRB	2689	0.21	0.58	YES
9	ALAD	ALAD	ALAD	3263	0.17	0.57	YES
10	FTH1	FTH1	FTH1	3863	0.13	0.56	YES
11	BLVRA	BLVRA	BLVRA	4066	0.12	0.57	YES
12	COX10	COX10	COX10	4337	0.11	0.58	YES
13	UROD	UROD	UROD	4395	0.11	0.59	YES
14	EARS2	EARS2	EARS2	5418	0.076	0.55	NO
15	FECH	FECH	FECH	6913	0.039	0.47	NO
16	PPOX	PPOX	PPOX	7242	0.031	0.46	NO
17	HMOX1	HMOX1	HMOX1	7512	0.025	0.45	NO
18	COX15	COX15	COX15	9007	-0.0043	0.36	NO
19	ALAS2	ALAS2	ALAS2	9031	-0.0046	0.36	NO
20	HMOX2	HMOX2	HMOX2	11067	-0.044	0.25	NO
21	CPOX	CPOX	CPOX	11586	-0.055	0.23	NO
22	UROS	UROS	UROS	12262	-0.071	0.21	NO
23	MMAB	MMAB	MMAB	13111	-0.093	0.18	NO
24	ALAS1	ALAS1	ALAS1	13411	-0.1	0.18	NO
25	GUSB	GUSB	GUSB	13561	-0.11	0.19	NO
26	HMBS	HMBS	HMBS	14297	-0.14	0.17	NO
27	EPRS	EPRS	EPRS	14410	-0.14	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD247	CD247	CD247	62	0.78	0.08	YES
2	CD3E	CD3E	CD3E	64	0.78	0.16	YES
3	PIK3CG	PIK3CG	PIK3CG	163	0.66	0.23	YES
4	CD3G	CD3G	CD3G	213	0.64	0.29	YES
5	CD3D	CD3D	CD3D	265	0.6	0.36	YES
6	PRKCA	PRKCA	PRKCA	301	0.59	0.42	YES
7	ZAP70	ZAP70	ZAP70	308	0.59	0.48	YES
8	LCK	LCK	LCK	342	0.57	0.54	YES
9	VAV1	VAV1	VAV1	889	0.42	0.55	YES
10	LAT	LAT	LAT	1652	0.3	0.54	YES
11	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.57	YES
12	NFATC2	NFATC2	NFATC2	2108	0.25	0.58	YES
13	NFATC3	NFATC3	NFATC3	3724	0.14	0.5	NO
14	FYN	FYN	FYN	4175	0.12	0.49	NO
15	MAPK3	MAPK3	MAPK3	4472	0.11	0.48	NO
16	MAP3K1	MAP3K1	MAP3K1	4767	0.097	0.48	NO
17	NFATC1	NFATC1	NFATC1	4772	0.097	0.49	NO
18	MAP2K4	MAP2K4	MAP2K4	4774	0.097	0.5	NO
19	NFKBIA	NFKBIA	NFKBIA	4886	0.094	0.5	NO
20	JUN	JUN	JUN	4911	0.093	0.51	NO
21	NFKB1	NFKB1	NFKB1	4945	0.091	0.52	NO
22	RASA1	RASA1	RASA1	5938	0.062	0.47	NO
23	FOS	FOS	FOS	6045	0.06	0.47	NO
24	PPP3CA	PPP3CA	PPP3CA	6175	0.056	0.47	NO
25	PRKCB	PRKCB	PRKCB	6978	0.037	0.42	NO
26	SOS1	SOS1	SOS1	6990	0.037	0.43	NO
27	PPP3CC	PPP3CC	PPP3CC	7429	0.027	0.41	NO
28	PLCG1	PLCG1	PLCG1	8085	0.014	0.37	NO
29	GRB2	GRB2	GRB2	8173	0.012	0.37	NO
30	RAF1	RAF1	RAF1	8205	0.012	0.37	NO
31	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.36	NO
32	RELA	RELA	RELA	8802	-0.00044	0.33	NO
33	SHC1	SHC1	SHC1	8921	-0.0026	0.33	NO
34	RAC1	RAC1	RAC1	9616	-0.016	0.29	NO
35	PPP3CB	PPP3CB	PPP3CB	10164	-0.026	0.26	NO
36	CALM1	CALM1	CALM1	10276	-0.029	0.26	NO
37	MAP2K1	MAP2K1	MAP2K1	12405	-0.074	0.15	NO
38	CALM3	CALM3	CALM3	12638	-0.08	0.14	NO
39	ELK1	ELK1	ELK1	12692	-0.081	0.15	NO
40	CALM2	CALM2	CALM2	12956	-0.089	0.14	NO
41	MAPK8	MAPK8	MAPK8	14381	-0.14	0.077	NO
42	PTPN7	PTPN7	PTPN7	15989	-0.27	0.015	NO
43	NFATC4	NFATC4	NFATC4	17665	-0.77	0.0029	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	LY96	LY96	LY96	51	0.79	0.2	YES
2	CD14	CD14	CD14	252	0.61	0.34	YES
3	TLR4	TLR4	TLR4	561	0.5	0.45	YES
4	PIK3R1	PIK3R1	PIK3R1	1657	0.3	0.46	YES
5	GJA1	GJA1	GJA1	2031	0.26	0.51	YES
6	MYD88	MYD88	MYD88	4115	0.12	0.42	NO
7	NFKB1	NFKB1	NFKB1	4945	0.091	0.4	NO
8	FZD1	FZD1	FZD1	5451	0.075	0.39	NO
9	WNT1	WNT1	WNT1	5893	0.063	0.38	NO
10	DVL1	DVL1	DVL1	6502	0.048	0.36	NO
11	TIRAP	TIRAP	TIRAP	6691	0.044	0.36	NO
12	APC	APC	APC	6769	0.042	0.36	NO
13	PDPK1	PDPK1	PDPK1	7074	0.035	0.36	NO
14	GNAI1	GNAI1	GNAI1	7799	0.02	0.32	NO
15	PIK3CA	PIK3CA	PIK3CA	8369	0.0084	0.29	NO
16	RELA	RELA	RELA	8802	-0.00044	0.27	NO
17	PPP2CA	PPP2CA	PPP2CA	8919	-0.0026	0.26	NO
18	GSK3B	GSK3B	GSK3B	9003	-0.0042	0.26	NO
19	AKT1	AKT1	AKT1	9017	-0.0045	0.26	NO
20	LBP	LBP	LBP	10154	-0.026	0.2	NO
21	AXIN1	AXIN1	AXIN1	10940	-0.041	0.17	NO
22	CCND1	CCND1	CCND1	12020	-0.065	0.12	NO
23	IRAK1	IRAK1	IRAK1	12302	-0.072	0.12	NO
24	EIF2AK2	EIF2AK2	EIF2AK2	13215	-0.096	0.097	NO
25	CTNNB1	CTNNB1	CTNNB1	14224	-0.14	0.074	NO
26	LEF1	LEF1	LEF1	17216	-0.49	0.028	NO