GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in BRCA-TP

Breast Invasive Carcinoma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in BRCA-TP. Broad Institute of MIT and Harvard. doi:10.7908/C14F1PQV

+ Overview

+ Introduction

+ Summary

basic data info
Number of Gene Sets: 192
Number of samples: 1093
Original number of Gene Sets: 404
Maximum gene set size: 388

phenotype info
pheno.type: 1 - 3 :[ clus1 ] 567
pheno.type: 2 - 3 :[ clus2 ] 311
pheno.type: 3 - 3 :[ clus3 ] 215

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA CARM ER PATHWAY	34	genes.ES.table	0.39	1.4	0.11	1	0.95	0.15	0.073	0.14	1	0.61
BIOCARTA MPR PATHWAY	32	genes.ES.table	0.34	1.2	0.26	1	1	0.062	0.005	0.062	0.94	0.46
KEGG OXIDATIVE PHOSPHORYLATION	113	genes.ES.table	0.13	0.46	0.91	0.99	1	0.27	0.26	0.2	0.99	0.45
KEGG PYRIMIDINE METABOLISM	96	genes.ES.table	0.16	0.72	0.82	0.95	1	0.094	0.1	0.084	0.95	0.36
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM	30	genes.ES.table	0.27	0.83	0.73	0.96	1	0.33	0.16	0.28	0.95	0.39
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION	43	genes.ES.table	0.35	1.3	0.22	1	0.99	0.19	0.13	0.16	1	0.64
KEGG SPHINGOLIPID METABOLISM	37	genes.ES.table	0.29	0.95	0.53	0.95	1	0.11	0.028	0.1	0.89	0.39
KEGG PYRUVATE METABOLISM	37	genes.ES.table	0.19	0.67	0.89	0.96	1	0.24	0.18	0.2	0.96	0.34
KEGG PROPANOATE METABOLISM	31	genes.ES.table	0.29	0.97	0.47	1	1	0.26	0.18	0.21	1	0.62
KEGG BUTANOATE METABOLISM	29	genes.ES.table	0.27	0.78	0.73	0.97	1	0.28	0.19	0.22	0.97	0.43

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ESR1	ESR1	ESR1	2	0.67	0.2	YES
2	CCND1	CCND1	CCND1	584	0.26	0.25	YES
3	HDAC11	HDAC11	HDAC11	801	0.22	0.31	YES
4	NRIP1	NRIP1	NRIP1	1206	0.18	0.34	YES
5	BRCA1	BRCA1	BRCA1	1339	0.16	0.39	YES
6	HIST2H3C	HIST2H3C	HIST2H3C	2641	0.095	0.34	NO
7	GTF2A1	GTF2A1	GTF2A1	3770	0.064	0.3	NO
8	HDAC10	HDAC10	HDAC10	4558	0.048	0.27	NO
9	CREBBP	CREBBP	CREBBP	4769	0.044	0.28	NO
10	POLR2A	POLR2A	POLR2A	4786	0.044	0.29	NO
11	GTF2F1	GTF2F1	GTF2F1	4886	0.042	0.3	NO
12	SRA1	SRA1	SRA1	5139	0.038	0.29	NO
13	NCOR2	NCOR2	NCOR2	5925	0.026	0.26	NO
14	GTF2E1	GTF2E1	GTF2E1	6097	0.023	0.26	NO
15	HDAC7	HDAC7	HDAC7	6284	0.021	0.25	NO
16	EP300	EP300	EP300	6482	0.018	0.25	NO
17	HDAC6	HDAC6	HDAC6	6682	0.015	0.24	NO
18	MED1	MED1	MED1	6842	0.013	0.24	NO
19	HDAC8	HDAC8	HDAC8	7027	0.01	0.23	NO
20	HDAC5	HDAC5	HDAC5	7316	0.0066	0.22	NO
21	PELP1	PELP1	PELP1	7439	0.0051	0.21	NO
22	HDAC1	HDAC1	HDAC1	7762	0.00082	0.19	NO
23	ERCC3	ERCC3	ERCC3	8131	-0.004	0.18	NO
24	HDAC3	HDAC3	HDAC3	9003	-0.015	0.13	NO
25	SPEN	SPEN	SPEN	9318	-0.02	0.12	NO
26	TBP	TBP	TBP	10016	-0.031	0.092	NO
27	NR0B1	NR0B1	NR0B1	10207	-0.033	0.092	NO
28	CARM1	CARM1	CARM1	11331	-0.052	0.046	NO
29	PHB2	PHB2	PHB2	11401	-0.054	0.059	NO
30	GRIP1	GRIP1	GRIP1	12915	-0.088	0.003	NO
31	HDAC2	HDAC2	HDAC2	13119	-0.093	0.02	NO
32	HDAC4	HDAC4	HDAC4	14510	-0.14	-0.012	NO
33	HDAC9	HDAC9	HDAC9	16614	-0.28	-0.042	NO
34	PPARGC1A	PPARGC1A	PPARGC1A	17806	-0.43	0.026	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ABAT	ABAT	ABAT	90	0.45	0.12	YES
2	ACADSB	ACADSB	ACADSB	250	0.36	0.21	YES
3	MCCC2	MCCC2	MCCC2	768	0.23	0.24	YES
4	IVD	IVD	IVD	1092	0.19	0.28	YES
5	ALDH6A1	ALDH6A1	ALDH6A1	1214	0.18	0.32	YES
6	BCAT2	BCAT2	BCAT2	1437	0.16	0.35	YES
7	HMGCL	HMGCL	HMGCL	2234	0.11	0.33	YES
8	ALDH3A2	ALDH3A2	ALDH3A2	2414	0.1	0.35	YES
9	HMGCS2	HMGCS2	HMGCS2	4267	0.054	0.26	NO
10	AUH	AUH	AUH	4353	0.052	0.28	NO
11	PCCB	PCCB	PCCB	4836	0.043	0.26	NO
12	ACAT1	ACAT1	ACAT1	4907	0.042	0.27	NO
13	MUT	MUT	MUT	5095	0.039	0.27	NO
14	MCEE	MCEE	MCEE	5107	0.039	0.28	NO
15	ACADS	ACADS	ACADS	5807	0.028	0.25	NO
16	DBT	DBT	DBT	5901	0.026	0.25	NO
17	BCKDHA	BCKDHA	BCKDHA	6022	0.024	0.25	NO
18	BCKDHB	BCKDHB	BCKDHB	6606	0.016	0.22	NO
19	PCCA	PCCA	PCCA	6742	0.014	0.22	NO
20	ALDH9A1	ALDH9A1	ALDH9A1	6746	0.014	0.22	NO
21	ECHS1	ECHS1	ECHS1	6942	0.012	0.22	NO
22	HADHB	HADHB	HADHB	7154	0.0087	0.2	NO
23	ACAA1	ACAA1	ACAA1	7302	0.0068	0.2	NO
24	HADH	HADH	HADH	7737	0.0011	0.18	NO
25	HIBCH	HIBCH	HIBCH	7887	-0.00075	0.17	NO
26	HIBADH	HIBADH	HIBADH	8686	-0.011	0.13	NO
27	HSD17B10	HSD17B10	HSD17B10	9154	-0.017	0.11	NO
28	ACAD8	ACAD8	ACAD8	9208	-0.018	0.11	NO
29	ACADM	ACADM	ACADM	9234	-0.019	0.11	NO
30	DLD	DLD	DLD	9855	-0.028	0.086	NO
31	HADHA	HADHA	HADHA	9888	-0.028	0.092	NO
32	ALDH7A1	ALDH7A1	ALDH7A1	10039	-0.031	0.092	NO
33	HMGCS1	HMGCS1	HMGCS1	10493	-0.038	0.077	NO
34	ALDH1B1	ALDH1B1	ALDH1B1	10741	-0.042	0.075	NO
35	ACAT2	ACAT2	ACAT2	11475	-0.055	0.05	NO
36	EHHADH	EHHADH	EHHADH	12181	-0.069	0.03	NO
37	ACAA2	ACAA2	ACAA2	12368	-0.074	0.04	NO
38	AOX1	AOX1	AOX1	13074	-0.092	0.026	NO
39	ALDH2	ALDH2	ALDH2	13116	-0.093	0.049	NO
40	MCCC1	MCCC1	MCCC1	14565	-0.14	0.0091	NO
41	OXCT1	OXCT1	OXCT1	14717	-0.15	0.042	NO
42	OXCT2	OXCT2	OXCT2	16548	-0.27	0.016	NO
43	IL4I1	IL4I1	IL4I1	16743	-0.29	0.084	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC27A2	SLC27A2	SLC27A2	87	0.46	0.058	YES
2	NUDT12	NUDT12	NUDT12	392	0.31	0.084	YES
3	PEX11G	PEX11G	PEX11G	634	0.25	0.11	YES
4	MPV17L	MPV17L	MPV17L	806	0.22	0.13	YES
5	PEX12	PEX12	PEX12	994	0.2	0.14	YES
6	PEX11A	PEX11A	PEX11A	1169	0.18	0.16	YES
7	CROT	CROT	CROT	1326	0.17	0.17	YES
8	DDO	DDO	DDO	1367	0.16	0.19	YES
9	PEX7	PEX7	PEX7	1534	0.15	0.21	YES
10	PECI	PECI	PECI	1591	0.15	0.22	YES
11	PECR	PECR	PECR	1723	0.14	0.24	YES
12	ABCD3	ABCD3	ABCD3	1742	0.14	0.25	YES
13	HSD17B4	HSD17B4	HSD17B4	1775	0.13	0.27	YES
14	PXMP4	PXMP4	PXMP4	1875	0.13	0.28	YES
15	DECR2	DECR2	DECR2	2117	0.12	0.28	YES
16	AMACR	AMACR	AMACR	2118	0.12	0.3	YES
17	HMGCL	HMGCL	HMGCL	2234	0.11	0.31	YES
18	FAR1	FAR1	FAR1	2272	0.11	0.32	YES
19	CRAT	CRAT	CRAT	2521	0.099	0.32	YES
20	PXMP2	PXMP2	PXMP2	2578	0.097	0.33	YES
21	PEX19	PEX19	PEX19	2951	0.085	0.32	NO
22	EPHX2	EPHX2	EPHX2	3376	0.074	0.31	NO
23	DHRS4	DHRS4	DHRS4	3702	0.066	0.3	NO
24	PEX2	PEX2	PEX2	3745	0.065	0.31	NO
25	PAOX	PAOX	PAOX	3774	0.064	0.32	NO
26	PEX1	PEX1	PEX1	3930	0.061	0.32	NO
27	PMVK	PMVK	PMVK	4215	0.055	0.31	NO
28	ACOX3	ACOX3	ACOX3	4287	0.054	0.31	NO
29	PEX11B	PEX11B	PEX11B	4431	0.051	0.31	NO
30	AGPS	AGPS	AGPS	4559	0.048	0.31	NO
31	HACL1	HACL1	HACL1	4862	0.043	0.3	NO
32	PEX10	PEX10	PEX10	5137	0.038	0.29	NO
33	SLC25A17	SLC25A17	SLC25A17	5570	0.031	0.27	NO
34	SOD1	SOD1	SOD1	5973	0.025	0.25	NO
35	ACOT8	ACOT8	ACOT8	6147	0.023	0.25	NO
36	ACSL3	ACSL3	ACSL3	6159	0.022	0.25	NO
37	SCP2	SCP2	SCP2	6199	0.022	0.25	NO
38	GNPAT	GNPAT	GNPAT	6607	0.016	0.23	NO
39	PEX16	PEX16	PEX16	7155	0.0087	0.2	NO
40	PHYH	PHYH	PHYH	7230	0.0078	0.2	NO
41	ACAA1	ACAA1	ACAA1	7302	0.0068	0.19	NO
42	ACOX1	ACOX1	ACOX1	7702	0.0016	0.17	NO
43	MPV17	MPV17	MPV17	7969	-0.0018	0.16	NO
44	FAR2	FAR2	FAR2	8166	-0.0044	0.15	NO
45	ABCD4	ABCD4	ABCD4	8186	-0.0046	0.15	NO
46	MVK	MVK	MVK	8286	-0.0059	0.14	NO
47	MLYCD	MLYCD	MLYCD	8313	-0.0062	0.14	NO
48	PEX6	PEX6	PEX6	8395	-0.0072	0.14	NO
49	PEX26	PEX26	PEX26	8437	-0.0078	0.14	NO
50	DAO	DAO	DAO	8886	-0.014	0.12	NO
51	PRDX1	PRDX1	PRDX1	8928	-0.014	0.12	NO
52	PEX5	PEX5	PEX5	8958	-0.015	0.12	NO
53	ECH1	ECH1	ECH1	9070	-0.016	0.11	NO
54	GSTK1	GSTK1	GSTK1	9086	-0.016	0.11	NO
55	PEX14	PEX14	PEX14	9482	-0.022	0.094	NO
56	PEX13	PEX13	PEX13	9673	-0.026	0.087	NO
57	CAT	CAT	CAT	9935	-0.029	0.077	NO
58	PRDX5	PRDX5	PRDX5	10231	-0.034	0.065	NO
59	HAO2	HAO2	HAO2	10479	-0.037	0.057	NO
60	AGXT	AGXT	AGXT	10875	-0.044	0.041	NO
61	PEX3	PEX3	PEX3	11054	-0.047	0.038	NO
62	IDH1	IDH1	IDH1	12130	-0.068	-0.012	NO
63	NUDT19	NUDT19	NUDT19	12145	-0.068	-0.003	NO
64	EHHADH	EHHADH	EHHADH	12181	-0.069	0.0046	NO
65	ABCD1	ABCD1	ABCD1	12553	-0.077	-0.005	NO
66	IDH2	IDH2	IDH2	12797	-0.084	-0.0068	NO
67	BAAT	BAAT	BAAT	13984	-0.12	-0.055	NO
68	PIPOX	PIPOX	PIPOX	13992	-0.12	-0.038	NO
69	NOS2	NOS2	NOS2	14707	-0.15	-0.057	NO
70	ACSL6	ACSL6	ACSL6	15016	-0.17	-0.051	NO
71	ACSL1	ACSL1	ACSL1	15209	-0.18	-0.037	NO
72	SOD2	SOD2	SOD2	15617	-0.2	-0.031	NO
73	ACSL4	ACSL4	ACSL4	16303	-0.25	-0.034	NO
74	ACSL5	ACSL5	ACSL5	16489	-0.27	-0.0076	NO
75	XDH	XDH	XDH	17211	-0.34	-2.9e-06	NO
76	ABCD2	ABCD2	ABCD2	17763	-0.42	0.028	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PGR	PGR	PGR	70	0.47	0.17	YES
2	MYT1	MYT1	MYT1	91	0.45	0.34	YES
3	PAQR5	PAQR5	PAQR5	1393	0.16	0.33	NO
4	MAPK3	MAPK3	MAPK3	2992	0.084	0.27	NO
5	PRKAR1A	PRKAR1A	PRKAR1A	3983	0.06	0.24	NO
6	PRKAR2B	PRKAR2B	PRKAR2B	4120	0.057	0.26	NO
7	PRKAR2A	PRKAR2A	PRKAR2A	4291	0.054	0.27	NO
8	CDC25C	CDC25C	CDC25C	5454	0.033	0.22	NO
9	PIN1	PIN1	PIN1	6004	0.025	0.2	NO
10	ARPC3	ARPC3	ARPC3	6154	0.023	0.2	NO
11	PAQR7	PAQR7	PAQR7	6934	0.012	0.16	NO
12	HRAS	HRAS	HRAS	6986	0.011	0.16	NO
13	GNB1	GNB1	GNB1	7760	0.00082	0.12	NO
14	MAPK1	MAPK1	MAPK1	8884	-0.014	0.06	NO
15	ACTA1	ACTA1	ACTA1	8888	-0.014	0.065	NO
16	CCNB1	CCNB1	CCNB1	9140	-0.017	0.058	NO
17	GNAS	GNAS	GNAS	9750	-0.027	0.034	NO
18	ARPC4	ARPC4	ARPC4	9988	-0.03	0.032	NO
19	ACTR2	ACTR2	ACTR2	10352	-0.035	0.026	NO
20	ARPC1A	ARPC1A	ARPC1A	10363	-0.036	0.038	NO
21	SRC	SRC	SRC	10408	-0.036	0.05	NO
22	CDK1	CDK1	CDK1	10417	-0.036	0.063	NO
23	CAP1	CAP1	CAP1	10463	-0.037	0.074	NO
24	GNGT1	GNGT1	GNGT1	10547	-0.039	0.084	NO
25	PRKACB	PRKACB	PRKACB	10809	-0.043	0.086	NO
26	ARPC5	ARPC5	ARPC5	11500	-0.056	0.069	NO
27	ARPC2	ARPC2	ARPC2	11798	-0.061	0.076	NO
28	RPS6KA1	RPS6KA1	RPS6KA1	12158	-0.069	0.082	NO
29	ACTR3	ACTR3	ACTR3	12653	-0.08	0.085	NO
30	ARPC1B	ARPC1B	ARPC1B	13090	-0.092	0.095	NO
31	PRKAR1B	PRKAR1B	PRKAR1B	14739	-0.15	0.062	NO
32	GNAI1	GNAI1	GNAI1	17274	-0.35	0.055	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NEIL1	NEIL1	NEIL1	1467	0.16	0.032	YES
2	POLD4	POLD4	POLD4	1733	0.14	0.12	YES
3	NTHL1	NTHL1	NTHL1	2568	0.098	0.14	YES
4	PARP3	PARP3	PARP3	2619	0.096	0.21	YES
5	LIG3	LIG3	LIG3	3360	0.074	0.22	YES
6	SMUG1	SMUG1	SMUG1	3464	0.072	0.26	YES
7	MPG	MPG	MPG	4058	0.058	0.28	YES
8	POLB	POLB	POLB	4116	0.057	0.31	YES
9	POLL	POLL	POLL	4124	0.057	0.35	YES
10	NEIL2	NEIL2	NEIL2	5640	0.03	0.29	NO
11	XRCC1	XRCC1	XRCC1	5871	0.027	0.3	NO
12	OGG1	OGG1	OGG1	6578	0.017	0.27	NO
13	LIG1	LIG1	LIG1	6955	0.011	0.26	NO
14	POLE	POLE	POLE	7326	0.0064	0.24	NO
15	POLE2	POLE2	POLE2	7506	0.0044	0.24	NO
16	APEX1	APEX1	APEX1	7574	0.0034	0.24	NO
17	PARP2	PARP2	PARP2	7724	0.0013	0.23	NO
18	PARP1	PARP1	PARP1	7866	-0.00049	0.22	NO
19	UNG	UNG	UNG	8013	-0.0024	0.22	NO
20	PCNA	PCNA	PCNA	8347	-0.0067	0.2	NO
21	POLD2	POLD2	POLD2	8508	-0.0087	0.2	NO
22	POLE3	POLE3	POLE3	8982	-0.015	0.18	NO
23	MBD4	MBD4	MBD4	9051	-0.016	0.19	NO
24	APEX2	APEX2	APEX2	9211	-0.018	0.2	NO
25	TDG	TDG	TDG	9541	-0.023	0.2	NO
26	NEIL3	NEIL3	NEIL3	9757	-0.027	0.2	NO
27	POLE4	POLE4	POLE4	9916	-0.029	0.22	NO
28	PARP4	PARP4	PARP4	9926	-0.029	0.24	NO
29	FEN1	FEN1	FEN1	10727	-0.041	0.22	NO
30	POLD3	POLD3	POLD3	11202	-0.05	0.23	NO
31	POLD1	POLD1	POLD1	13147	-0.094	0.19	NO
32	MUTYH	MUTYH	MUTYH	14037	-0.12	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLD4	POLD4	POLD4	1733	0.14	-0.032	YES
2	MNAT1	MNAT1	MNAT1	2016	0.12	0.0081	YES
3	ERCC4	ERCC4	ERCC4	2134	0.12	0.055	YES
4	CCNH	CCNH	CCNH	2418	0.1	0.087	YES
5	XPA	XPA	XPA	2699	0.093	0.11	YES
6	CDK7	CDK7	CDK7	2805	0.09	0.15	YES
7	GTF2H2	GTF2H2	GTF2H2	2977	0.084	0.18	YES
8	CETN2	CETN2	CETN2	3131	0.08	0.21	YES
9	XPC	XPC	XPC	3530	0.07	0.22	YES
10	GTF2H3	GTF2H3	GTF2H3	3613	0.069	0.25	YES
11	DDB2	DDB2	DDB2	3799	0.064	0.26	YES
12	RPA3	RPA3	RPA3	4438	0.051	0.25	YES
13	GTF2H5	GTF2H5	GTF2H5	4520	0.049	0.27	YES
14	RFC1	RFC1	RFC1	4758	0.045	0.28	YES
15	RFC5	RFC5	RFC5	5243	0.036	0.27	NO
16	ERCC8	ERCC8	ERCC8	6356	0.02	0.22	NO
17	DDB1	DDB1	DDB1	6859	0.013	0.2	NO
18	LIG1	LIG1	LIG1	6955	0.011	0.2	NO
19	ERCC6	ERCC6	ERCC6	6973	0.011	0.2	NO
20	CUL4A	CUL4A	CUL4A	7212	0.008	0.19	NO
21	ERCC2	ERCC2	ERCC2	7261	0.0074	0.19	NO
22	POLE	POLE	POLE	7326	0.0064	0.19	NO
23	POLE2	POLE2	POLE2	7506	0.0044	0.18	NO
24	CUL4B	CUL4B	CUL4B	7636	0.0025	0.18	NO
25	ERCC3	ERCC3	ERCC3	8131	-0.004	0.15	NO
26	ERCC1	ERCC1	ERCC1	8160	-0.0043	0.15	NO
27	PCNA	PCNA	PCNA	8347	-0.0067	0.15	NO
28	POLD2	POLD2	POLD2	8508	-0.0087	0.14	NO
29	GTF2H1	GTF2H1	GTF2H1	8518	-0.0088	0.14	NO
30	ERCC5	ERCC5	ERCC5	8891	-0.014	0.13	NO
31	POLE3	POLE3	POLE3	8982	-0.015	0.13	NO
32	RAD23A	RAD23A	RAD23A	8983	-0.015	0.14	NO
33	RBX1	RBX1	RBX1	9729	-0.026	0.11	NO
34	POLE4	POLE4	POLE4	9916	-0.029	0.11	NO
35	RPA2	RPA2	RPA2	10037	-0.031	0.12	NO
36	RPA1	RPA1	RPA1	10321	-0.035	0.12	NO
37	POLD3	POLD3	POLD3	11202	-0.05	0.097	NO
38	GTF2H4	GTF2H4	GTF2H4	11628	-0.058	0.1	NO
39	RFC2	RFC2	RFC2	11974	-0.065	0.11	NO
40	RFC3	RFC3	RFC3	12306	-0.072	0.13	NO
41	POLD1	POLD1	POLD1	13147	-0.094	0.12	NO
42	RFC4	RFC4	RFC4	13286	-0.099	0.16	NO
43	RPA4	RPA4	RPA4	16185	-0.24	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ABAT	ABAT	ABAT	90	0.45	0.18	YES
2	ALDH6A1	ALDH6A1	ALDH6A1	1214	0.18	0.19	YES
3	ACSS3	ACSS3	ACSS3	2075	0.12	0.19	YES
4	ALDH3A2	ALDH3A2	ALDH3A2	2414	0.1	0.21	YES
5	LDHAL6A	LDHAL6A	LDHAL6A	3130	0.08	0.21	YES
6	ACSS1	ACSS1	ACSS1	3208	0.078	0.23	YES
7	SUCLG2	SUCLG2	SUCLG2	3219	0.078	0.26	YES
8	ACACA	ACACA	ACACA	3261	0.077	0.29	YES
9	PCCB	PCCB	PCCB	4836	0.043	0.23	NO
10	ACAT1	ACAT1	ACAT1	4907	0.042	0.24	NO
11	MUT	MUT	MUT	5095	0.039	0.24	NO
12	MCEE	MCEE	MCEE	5107	0.039	0.26	NO
13	SUCLA2	SUCLA2	SUCLA2	5552	0.032	0.25	NO
14	ACACB	ACACB	ACACB	6089	0.023	0.23	NO
15	PCCA	PCCA	PCCA	6742	0.014	0.2	NO
16	ALDH9A1	ALDH9A1	ALDH9A1	6746	0.014	0.2	NO
17	ECHS1	ECHS1	ECHS1	6942	0.012	0.2	NO
18	HIBCH	HIBCH	HIBCH	7887	-0.00075	0.15	NO
19	MLYCD	MLYCD	MLYCD	8313	-0.0062	0.13	NO
20	LDHA	LDHA	LDHA	8436	-0.0077	0.12	NO
21	ACADM	ACADM	ACADM	9234	-0.019	0.086	NO
22	ACSS2	ACSS2	ACSS2	9529	-0.023	0.08	NO
23	HADHA	HADHA	HADHA	9888	-0.028	0.072	NO
24	ALDH7A1	ALDH7A1	ALDH7A1	10039	-0.031	0.076	NO
25	SUCLG1	SUCLG1	SUCLG1	10698	-0.041	0.057	NO
26	ALDH1B1	ALDH1B1	ALDH1B1	10741	-0.042	0.071	NO
27	ACAT2	ACAT2	ACAT2	11475	-0.055	0.054	NO
28	EHHADH	EHHADH	EHHADH	12181	-0.069	0.043	NO
29	ALDH2	ALDH2	ALDH2	13116	-0.093	0.03	NO
30	LDHAL6B	LDHAL6B	LDHAL6B	16860	-0.3	-0.053	NO
31	LDHB	LDHB	LDHB	17023	-0.32	0.069	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CACNA2D2	CACNA2D2	CACNA2D2	16	0.56	0.077	YES
2	CACNG1	CACNG1	CACNG1	205	0.38	0.12	YES
3	CACNG4	CACNG4	CACNG4	234	0.37	0.17	YES
4	CACNA1D	CACNA1D	CACNA1D	281	0.35	0.22	YES
5	COX6C	COX6C	COX6C	432	0.3	0.25	YES
6	CACNA1F	CACNA1F	CACNA1F	486	0.29	0.28	YES
7	ATP1A4	ATP1A4	ATP1A4	596	0.26	0.32	YES
8	TNNI3	TNNI3	TNNI3	1143	0.18	0.31	YES
9	CACNG6	CACNG6	CACNG6	1361	0.16	0.32	YES
10	COX6A2	COX6A2	COX6A2	2264	0.11	0.29	NO
11	CACNB2	CACNB2	CACNB2	2879	0.087	0.26	NO
12	CACNA2D4	CACNA2D4	CACNA2D4	3125	0.08	0.26	NO
13	ATP1A3	ATP1A3	ATP1A3	3297	0.076	0.26	NO
14	CACNB3	CACNB3	CACNB3	3537	0.07	0.26	NO
15	COX6A1	COX6A1	COX6A1	3677	0.067	0.26	NO
16	ATP1A2	ATP1A2	ATP1A2	3727	0.066	0.27	NO
17	UQCRQ	UQCRQ	UQCRQ	4273	0.054	0.25	NO
18	COX7C	COX7C	COX7C	4449	0.05	0.24	NO
19	SLC9A1	SLC9A1	SLC9A1	4478	0.05	0.25	NO
20	TNNC1	TNNC1	TNNC1	5211	0.037	0.21	NO
21	UQCR11	UQCR11	UQCR11	5321	0.035	0.21	NO
22	COX7A2	COX7A2	COX7A2	6616	0.016	0.14	NO
23	COX8A	COX8A	COX8A	7149	0.0088	0.12	NO
24	ATP1B1	ATP1B1	ATP1B1	7371	0.0059	0.1	NO
25	ATP2A2	ATP2A2	ATP2A2	7451	0.005	0.1	NO
26	COX7A1	COX7A1	COX7A1	7507	0.0044	0.098	NO
27	TPM3	TPM3	TPM3	7583	0.0033	0.095	NO
28	CACNA2D1	CACNA2D1	CACNA2D1	7619	0.0028	0.093	NO
29	UQCRC1	UQCRC1	UQCRC1	7844	-0.00022	0.081	NO
30	COX4I2	COX4I2	COX4I2	8245	-0.0054	0.06	NO
31	CYC1	CYC1	CYC1	8348	-0.0067	0.055	NO
32	COX7A2L	COX7A2L	COX7A2L	8364	-0.0069	0.055	NO
33	UQCR10	UQCR10	UQCR10	8814	-0.013	0.032	NO
34	UQCRB	UQCRB	UQCRB	9441	-0.022	0.00094	NO
35	COX6B1	COX6B1	COX6B1	9462	-0.022	0.0029	NO
36	COX5B	COX5B	COX5B	10317	-0.035	-0.039	NO
37	COX5A	COX5A	COX5A	10347	-0.035	-0.036	NO
38	COX7B	COX7B	COX7B	10348	-0.035	-0.031	NO
39	CACNA1S	CACNA1S	CACNA1S	10657	-0.04	-0.042	NO
40	TPM1	TPM1	TPM1	10659	-0.04	-0.037	NO
41	ACTC1	ACTC1	ACTC1	11093	-0.048	-0.054	NO
42	CACNA1C	CACNA1C	CACNA1C	11220	-0.05	-0.054	NO
43	UQCRFS1	UQCRFS1	UQCRFS1	11268	-0.051	-0.05	NO
44	TPM4	TPM4	TPM4	11337	-0.052	-0.046	NO
45	CACNB4	CACNB4	CACNB4	11812	-0.062	-0.064	NO
46	SLC8A1	SLC8A1	SLC8A1	12018	-0.066	-0.066	NO
47	ATP1A1	ATP1A1	ATP1A1	12366	-0.074	-0.075	NO
48	MYL3	MYL3	MYL3	12498	-0.076	-0.071	NO
49	COX4I1	COX4I1	COX4I1	12701	-0.081	-0.071	NO
50	CACNA2D3	CACNA2D3	CACNA2D3	12855	-0.086	-0.068	NO
51	CACNB1	CACNB1	CACNB1	12882	-0.086	-0.057	NO
52	MYL2	MYL2	MYL2	13679	-0.11	-0.085	NO
53	ATP1B3	ATP1B3	ATP1B3	13689	-0.11	-0.07	NO
54	MYH6	MYH6	MYH6	13932	-0.12	-0.067	NO
55	ATP1B2	ATP1B2	ATP1B2	14017	-0.12	-0.054	NO
56	UQCRH	UQCRH	UQCRH	14073	-0.12	-0.04	NO
57	COX6B2	COX6B2	COX6B2	14209	-0.13	-0.03	NO
58	MYH7	MYH7	MYH7	14638	-0.15	-0.032	NO
59	TPM2	TPM2	TPM2	14869	-0.16	-0.023	NO
60	UQCRHL	UQCRHL	UQCRHL	14957	-0.16	-0.0053	NO
61	RYR2	RYR2	RYR2	15979	-0.23	-0.03	NO
62	SLC9A6	SLC9A6	SLC9A6	16599	-0.28	-0.026	NO
63	FXYD2	FXYD2	FXYD2	17692	-0.41	-0.029	NO
64	TNNT2	TNNT2	TNNT2	17832	-0.44	0.024	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	DEGS2	DEGS2	DEGS2	60	0.48	0.1	YES
2	UGCG	UGCG	UGCG	303	0.34	0.17	YES
3	SMPD3	SMPD3	SMPD3	333	0.33	0.24	YES
4	ACER2	ACER2	ACER2	519	0.28	0.29	YES
5	ASAH1	ASAH1	ASAH1	1779	0.13	0.25	NO
6	ASAH2	ASAH2	ASAH2	1849	0.13	0.28	NO
7	GALC	GALC	GALC	3262	0.077	0.22	NO
8	SPTLC2	SPTLC2	SPTLC2	3627	0.068	0.21	NO
9	NEU3	NEU3	NEU3	3914	0.061	0.21	NO
10	SGPL1	SGPL1	SGPL1	4406	0.051	0.19	NO
11	SPHK2	SPHK2	SPHK2	4446	0.05	0.2	NO
12	NEU1	NEU1	NEU1	4484	0.05	0.21	NO
13	GBA	GBA	GBA	5999	0.025	0.14	NO
14	SPTLC1	SPTLC1	SPTLC1	6115	0.023	0.13	NO
15	KDSR	KDSR	KDSR	6666	0.016	0.11	NO
16	SMPD2	SMPD2	SMPD2	6914	0.012	0.096	NO
17	SMPD1	SMPD1	SMPD1	7014	0.011	0.093	NO
18	ARSA	ARSA	ARSA	7452	0.005	0.07	NO
19	SMPD4	SMPD4	SMPD4	8461	-0.0081	0.017	NO
20	GLA	GLA	GLA	8619	-0.01	0.01	NO
21	NEU4	NEU4	NEU4	9111	-0.017	-0.013	NO
22	GLB1	GLB1	GLB1	9536	-0.023	-0.031	NO
23	SGMS1	SGMS1	SGMS1	9778	-0.027	-0.038	NO
24	ACER3	ACER3	ACER3	10045	-0.031	-0.046	NO
25	SGPP1	SGPP1	SGPP1	10061	-0.031	-0.04	NO
26	PPAP2C	PPAP2C	PPAP2C	11255	-0.051	-0.094	NO
27	DEGS1	DEGS1	DEGS1	11283	-0.051	-0.084	NO
28	ACER1	ACER1	ACER1	11831	-0.062	-0.1	NO
29	PPAP2A	PPAP2A	PPAP2A	12808	-0.084	-0.14	NO
30	CERK	CERK	CERK	12820	-0.084	-0.12	NO
31	B4GALT6	B4GALT6	B4GALT6	13656	-0.11	-0.14	NO
32	PPAP2B	PPAP2B	PPAP2B	14441	-0.14	-0.15	NO
33	SGMS2	SGMS2	SGMS2	14765	-0.15	-0.13	NO
34	SPHK1	SPHK1	SPHK1	16541	-0.27	-0.17	NO
35	SGPP2	SGPP2	SGPP2	16550	-0.27	-0.11	NO
36	GAL3ST1	GAL3ST1	GAL3ST1	16700	-0.29	-0.055	NO
37	UGT8	UGT8	UGT8	18206	-0.64	0.0038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SEPSECS	SEPSECS	SEPSECS	1117	0.18	0.046	YES
2	EARS2	EARS2	EARS2	1951	0.12	0.072	YES
3	HARS2	HARS2	HARS2	3947	0.06	-0.0017	YES
4	IARS2	IARS2	IARS2	3976	0.06	0.032	YES
5	DARS2	DARS2	DARS2	4193	0.056	0.052	YES
6	VARS2	VARS2	VARS2	4523	0.049	0.063	YES
7	LARS2	LARS2	LARS2	4840	0.043	0.071	YES
8	RARS	RARS	RARS	5490	0.032	0.054	YES
9	FARS2	FARS2	FARS2	5589	0.031	0.067	YES
10	NARS	NARS	NARS	5937	0.026	0.063	YES
11	HARS	HARS	HARS	6059	0.024	0.07	YES
12	LARS	LARS	LARS	6791	0.014	0.038	YES
13	SARS	SARS	SARS	7321	0.0065	0.013	YES
14	WARS2	WARS2	WARS2	7397	0.0056	0.012	YES
15	FARSA	FARSA	FARSA	7539	0.0041	0.0064	YES
16	MTFMT	MTFMT	MTFMT	7895	-0.00086	-0.012	YES
17	TARSL2	TARSL2	TARSL2	8046	-0.003	-0.019	YES
18	QARS	QARS	QARS	8434	-0.0077	-0.036	YES
19	IARS	IARS	IARS	8466	-0.0081	-0.033	YES
20	CARS	CARS	CARS	8786	-0.012	-0.043	YES
21	YARS2	YARS2	YARS2	9253	-0.019	-0.057	YES
22	NARS2	NARS2	NARS2	9317	-0.02	-0.049	YES
23	EPRS	EPRS	EPRS	9432	-0.022	-0.043	YES
24	PARS2	PARS2	PARS2	9775	-0.027	-0.046	YES
25	MARS	MARS	MARS	9860	-0.028	-0.034	YES
26	MARS2	MARS2	MARS2	9872	-0.028	-0.018	YES
27	FARSB	FARSB	FARSB	9919	-0.029	-0.004	YES
28	RARS2	RARS2	RARS2	10805	-0.043	-0.028	YES
29	DARS	DARS	DARS	10923	-0.045	-0.0079	YES
30	AARS	AARS	AARS	10930	-0.045	0.018	YES
31	CARS2	CARS2	CARS2	10994	-0.046	0.041	YES
32	PSTK	PSTK	PSTK	11065	-0.047	0.065	YES
33	SARS2	SARS2	SARS2	11242	-0.05	0.085	YES
34	TARS	TARS	TARS	11266	-0.051	0.11	YES
35	AARS2	AARS2	AARS2	11743	-0.06	0.12	YES
36	VARS	VARS	VARS	11805	-0.062	0.16	YES
37	YARS	YARS	YARS	11970	-0.065	0.18	YES
38	GARS	GARS	GARS	12383	-0.074	0.2	YES
39	KARS	KARS	KARS	12916	-0.088	0.23	YES
40	WARS	WARS	WARS	13840	-0.12	0.24	YES

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA G1 PATHWAY	27	genes.ES.table	0.55	1.6	0.022	0.51	0.68	0.26	0.075	0.24	0.3	0.15
BIOCARTA RACCYCD PATHWAY	25	genes.ES.table	0.39	1.6	0.065	0.59	0.79	0.08	0.039	0.077	0.36	0.19
KEGG CYSTEINE AND METHIONINE METABOLISM	32	genes.ES.table	0.45	1.4	0.058	0.62	0.92	0.38	0.19	0.3	0.42	0.21
KEGG LYSINE DEGRADATION	43	genes.ES.table	0.44	1.9	0.0019	0.24	0.13	0.23	0.17	0.19	0	0.088
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES	25	genes.ES.table	0.74	1.8	0	0.33	0.38	0.44	0.096	0.4	0	0.083
KEGG AMINOACYL TRNA BIOSYNTHESIS	40	genes.ES.table	0.35	1.4	0.16	0.64	0.96	0.5	0.34	0.33	0.47	0.2
KEGG RNA POLYMERASE	28	genes.ES.table	0.44	1.5	0.12	0.69	0.9	0.64	0.37	0.4	0.46	0.24
KEGG DNA REPLICATION	35	genes.ES.table	0.59	1.5	0.099	0.59	0.83	0.54	0.22	0.43	0.37	0.19
KEGG SPLICEOSOME	125	genes.ES.table	0.35	1.4	0.15	0.61	0.94	0.52	0.38	0.32	0.43	0.2
KEGG PROTEASOME	42	genes.ES.table	0.59	1.7	0.053	0.48	0.56	0.79	0.35	0.51	0.24	0.14

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AADAT	AADAT	AADAT	167	0.57	0.12	YES
2	BBOX1	BBOX1	BBOX1	305	0.5	0.22	YES
3	SUV39H2	SUV39H2	SUV39H2	937	0.34	0.26	YES
4	OGDHL	OGDHL	OGDHL	1371	0.28	0.3	YES
5	PLOD1	PLOD1	PLOD1	1999	0.22	0.32	YES
6	PLOD2	PLOD2	PLOD2	2472	0.18	0.33	YES
7	PIPOX	PIPOX	PIPOX	2764	0.17	0.35	YES
8	PLOD3	PLOD3	PLOD3	2785	0.17	0.39	YES
9	ACAT2	ACAT2	ACAT2	2895	0.16	0.42	YES
10	SUV39H1	SUV39H1	SUV39H1	3137	0.15	0.44	YES
11	ALDH1B1	ALDH1B1	ALDH1B1	4993	0.084	0.36	NO
12	SETD8	SETD8	SETD8	5111	0.081	0.37	NO
13	DOT1L	DOT1L	DOT1L	5969	0.062	0.33	NO
14	EHMT2	EHMT2	EHMT2	6367	0.054	0.32	NO
15	ALDH7A1	ALDH7A1	ALDH7A1	6867	0.042	0.31	NO
16	SETDB1	SETDB1	SETDB1	7156	0.036	0.3	NO
17	WHSC1	WHSC1	WHSC1	7763	0.024	0.27	NO
18	TMLHE	TMLHE	TMLHE	7922	0.022	0.27	NO
19	OGDH	OGDH	OGDH	8056	0.019	0.26	NO
20	HADHA	HADHA	HADHA	8162	0.017	0.26	NO
21	DLST	DLST	DLST	9036	0.00072	0.21	NO
22	AASDHPPT	AASDHPPT	AASDHPPT	9173	-0.002	0.21	NO
23	ECHS1	ECHS1	ECHS1	9481	-0.008	0.19	NO
24	SUV420H1	SUV420H1	SUV420H1	9856	-0.015	0.18	NO
25	NSD1	NSD1	NSD1	9959	-0.017	0.17	NO
26	HADH	HADH	HADH	9994	-0.018	0.18	NO
27	SETD1A	SETD1A	SETD1A	10033	-0.018	0.18	NO
28	ALDH9A1	ALDH9A1	ALDH9A1	10121	-0.02	0.18	NO
29	SETMAR	SETMAR	SETMAR	10636	-0.03	0.16	NO
30	ACAT1	ACAT1	ACAT1	10986	-0.036	0.14	NO
31	SUV420H2	SUV420H2	SUV420H2	11061	-0.038	0.15	NO
32	GCDH	GCDH	GCDH	11257	-0.042	0.15	NO
33	ALDH2	ALDH2	ALDH2	11271	-0.042	0.16	NO
34	SETD1B	SETD1B	SETD1B	11591	-0.049	0.15	NO
35	SETD2	SETD2	SETD2	11733	-0.053	0.15	NO
36	EHMT1	EHMT1	EHMT1	12305	-0.065	0.14	NO
37	ASH1L	ASH1L	ASH1L	12971	-0.083	0.12	NO
38	AASDH	AASDH	AASDH	12987	-0.084	0.14	NO
39	SETD7	SETD7	SETD7	13227	-0.09	0.14	NO
40	WHSC1L1	WHSC1L1	WHSC1L1	13326	-0.093	0.16	NO
41	SETDB2	SETDB2	SETDB2	14137	-0.12	0.14	NO
42	ALDH3A2	ALDH3A2	ALDH3A2	15147	-0.16	0.12	NO
43	AASS	AASS	AASS	16244	-0.23	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCNE1	CCNE1	CCNE1	4	0.88	0.04	YES
2	SMC1B	SMC1B	SMC1B	67	0.66	0.067	YES
3	ORC6L	ORC6L	ORC6L	125	0.6	0.092	YES
4	ORC1L	ORC1L	ORC1L	135	0.59	0.12	YES
5	CDC25A	CDC25A	CDC25A	190	0.56	0.14	YES
6	CDC45	CDC45	CDC45	203	0.55	0.17	YES
7	TTK	TTK	TTK	255	0.52	0.19	YES
8	CDC20	CDC20	CDC20	283	0.51	0.21	YES
9	E2F2	E2F2	E2F2	348	0.48	0.23	YES
10	CDKN2A	CDKN2A	CDKN2A	400	0.46	0.25	YES
11	PLK1	PLK1	PLK1	508	0.43	0.26	YES
12	CCNB2	CCNB2	CCNB2	515	0.43	0.28	YES
13	BUB1	BUB1	BUB1	574	0.41	0.3	YES
14	CCNA2	CCNA2	CCNA2	615	0.4	0.31	YES
15	SKP2	SKP2	SKP2	649	0.39	0.33	YES
16	PTTG1	PTTG1	PTTG1	693	0.38	0.34	YES
17	CDK6	CDK6	CDK6	709	0.38	0.36	YES
18	CHEK1	CHEK1	CHEK1	766	0.36	0.37	YES
19	E2F1	E2F1	E2F1	954	0.33	0.38	YES
20	CCNA1	CCNA1	CCNA1	965	0.33	0.39	YES
21	BUB1B	BUB1B	BUB1B	1002	0.33	0.41	YES
22	CDC25C	CDC25C	CDC25C	1023	0.32	0.42	YES
23	CDC6	CDC6	CDC6	1032	0.32	0.44	YES
24	CDC7	CDC7	CDC7	1101	0.31	0.45	YES
25	PKMYT1	PKMYT1	PKMYT1	1213	0.3	0.45	YES
26	MAD2L1	MAD2L1	MAD2L1	1242	0.29	0.46	YES
27	CCNE2	CCNE2	CCNE2	1365	0.28	0.47	YES
28	CDK1	CDK1	CDK1	1374	0.28	0.48	YES
29	E2F3	E2F3	E2F3	1383	0.28	0.5	YES
30	CHEK2	CHEK2	CHEK2	1436	0.27	0.51	YES
31	CDC25B	CDC25B	CDC25B	1477	0.27	0.52	YES
32	ESPL1	ESPL1	ESPL1	1493	0.26	0.53	YES
33	CCNB1	CCNB1	CCNB1	1911	0.22	0.51	YES
34	MCM2	MCM2	MCM2	1977	0.22	0.52	YES
35	MCM5	MCM5	MCM5	2036	0.21	0.53	YES
36	MCM4	MCM4	MCM4	2100	0.21	0.53	YES
37	MCM7	MCM7	MCM7	2121	0.21	0.54	YES
38	RBL1	RBL1	RBL1	2186	0.2	0.55	YES
39	MCM6	MCM6	MCM6	2196	0.2	0.56	YES
40	HDAC2	HDAC2	HDAC2	2450	0.18	0.55	YES
41	E2F5	E2F5	E2F5	2522	0.18	0.56	YES
42	PTTG2	PTTG2	PTTG2	2524	0.18	0.56	YES
43	MAD2L2	MAD2L2	MAD2L2	2638	0.18	0.57	YES
44	CDKN2C	CDKN2C	CDKN2C	2733	0.17	0.57	YES
45	SFN	SFN	SFN	3144	0.15	0.55	NO
46	TFDP1	TFDP1	TFDP1	3280	0.14	0.55	NO
47	MCM3	MCM3	MCM3	3307	0.14	0.56	NO
48	TFDP2	TFDP2	TFDP2	3463	0.14	0.56	NO
49	CDKN2D	CDKN2D	CDKN2D	3624	0.13	0.55	NO
50	E2F4	E2F4	E2F4	3668	0.13	0.56	NO
51	PCNA	PCNA	PCNA	3962	0.12	0.55	NO
52	YWHAQ	YWHAQ	YWHAQ	3992	0.11	0.55	NO
53	CDK4	CDK4	CDK4	4235	0.11	0.54	NO
54	MYC	MYC	MYC	4309	0.1	0.54	NO
55	PRKDC	PRKDC	PRKDC	4619	0.095	0.53	NO
56	TGFB2	TGFB2	TGFB2	4818	0.088	0.52	NO
57	CDC14B	CDC14B	CDC14B	5056	0.083	0.51	NO
58	YWHAZ	YWHAZ	YWHAZ	5085	0.082	0.51	NO
59	RBX1	RBX1	RBX1	5139	0.081	0.52	NO
60	CDK2	CDK2	CDK2	5278	0.077	0.51	NO
61	ANAPC1	ANAPC1	ANAPC1	5393	0.074	0.51	NO
62	CDKN2B	CDKN2B	CDKN2B	5502	0.072	0.51	NO
63	RAD21	RAD21	RAD21	5564	0.071	0.51	NO
64	CUL1	CUL1	CUL1	5608	0.07	0.51	NO
65	ORC3L	ORC3L	ORC3L	5665	0.069	0.51	NO
66	CCND3	CCND3	CCND3	5675	0.069	0.51	NO
67	YWHAH	YWHAH	YWHAH	5831	0.065	0.5	NO
68	CDC26	CDC26	CDC26	5876	0.064	0.5	NO
69	YWHAG	YWHAG	YWHAG	6083	0.06	0.5	NO
70	MAD1L1	MAD1L1	MAD1L1	6242	0.056	0.49	NO
71	SMC1A	SMC1A	SMC1A	6529	0.05	0.48	NO
72	ANAPC11	ANAPC11	ANAPC11	6730	0.046	0.47	NO
73	ORC5L	ORC5L	ORC5L	7169	0.036	0.44	NO
74	YWHAE	YWHAE	YWHAE	7575	0.028	0.42	NO
75	ATR	ATR	ATR	7611	0.028	0.42	NO
76	SMC3	SMC3	SMC3	7826	0.023	0.41	NO
77	ZBTB17	ZBTB17	ZBTB17	7926	0.022	0.41	NO
78	GADD45A	GADD45A	GADD45A	7976	0.02	0.41	NO
79	GSK3B	GSK3B	GSK3B	8025	0.02	0.4	NO
80	ANAPC10	ANAPC10	ANAPC10	8026	0.019	0.4	NO
81	HDAC1	HDAC1	HDAC1	8117	0.018	0.4	NO
82	ANAPC7	ANAPC7	ANAPC7	8167	0.017	0.4	NO
83	CDKN1C	CDKN1C	CDKN1C	8361	0.013	0.39	NO
84	ANAPC5	ANAPC5	ANAPC5	8449	0.012	0.38	NO
85	CDC16	CDC16	CDC16	8458	0.011	0.38	NO
86	SMAD2	SMAD2	SMAD2	8709	0.0068	0.37	NO
87	ORC2L	ORC2L	ORC2L	9082	-3e-05	0.35	NO
88	STAG1	STAG1	STAG1	9237	-0.0035	0.34	NO
89	ORC4L	ORC4L	ORC4L	9559	-0.0094	0.33	NO
90	YWHAB	YWHAB	YWHAB	9909	-0.016	0.31	NO
91	CCND2	CCND2	CCND2	10075	-0.019	0.3	NO
92	WEE1	WEE1	WEE1	10103	-0.02	0.3	NO
93	WEE2	WEE2	WEE2	10215	-0.022	0.29	NO
94	ATM	ATM	ATM	10312	-0.024	0.29	NO
95	ABL1	ABL1	ABL1	10444	-0.026	0.28	NO
96	CDC27	CDC27	CDC27	10685	-0.031	0.27	NO
97	CDC23	CDC23	CDC23	10736	-0.032	0.27	NO
98	STAG2	STAG2	STAG2	10744	-0.032	0.27	NO
99	EP300	EP300	EP300	10754	-0.032	0.27	NO
100	ANAPC4	ANAPC4	ANAPC4	11069	-0.038	0.26	NO
101	TP53	TP53	TP53	11129	-0.039	0.26	NO
102	FZR1	FZR1	FZR1	11185	-0.04	0.25	NO
103	SMAD4	SMAD4	SMAD4	11672	-0.051	0.23	NO
104	GADD45B	GADD45B	GADD45B	11837	-0.055	0.22	NO
105	ANAPC13	ANAPC13	ANAPC13	12181	-0.062	0.21	NO
106	BUB3	BUB3	BUB3	12391	-0.067	0.2	NO
107	TGFB1	TGFB1	TGFB1	12651	-0.074	0.19	NO
108	CDKN1A	CDKN1A	CDKN1A	12820	-0.079	0.18	NO
109	CDK7	CDK7	CDK7	13004	-0.084	0.18	NO
110	CREBBP	CREBBP	CREBBP	13009	-0.084	0.18	NO
111	ANAPC2	ANAPC2	ANAPC2	13269	-0.091	0.17	NO
112	RBL2	RBL2	RBL2	13572	-0.1	0.16	NO
113	CDKN1B	CDKN1B	CDKN1B	14036	-0.12	0.14	NO
114	CCNB3	CCNB3	CCNB3	14394	-0.13	0.12	NO
115	MDM2	MDM2	MDM2	14430	-0.13	0.13	NO
116	SKP1	SKP1	SKP1	14557	-0.14	0.13	NO
117	RB1	RB1	RB1	15123	-0.16	0.1	NO
118	CCNH	CCNH	CCNH	15389	-0.17	0.096	NO
119	SMAD3	SMAD3	SMAD3	15476	-0.18	0.1	NO
120	CDC14A	CDC14A	CDC14A	15983	-0.21	0.081	NO
121	TGFB3	TGFB3	TGFB3	16933	-0.3	0.043	NO
122	GADD45G	GADD45G	GADD45G	17198	-0.34	0.044	NO
123	CCND1	CCND1	CCND1	17209	-0.34	0.059	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	B3GNT5	B3GNT5	B3GNT5	24	0.73	0.12	YES
2	B3GNT4	B3GNT4	B3GNT4	50	0.68	0.22	YES
3	FUT3	FUT3	FUT3	73	0.66	0.33	YES
4	ST8SIA1	ST8SIA1	ST8SIA1	131	0.6	0.42	YES
5	B3GNT3	B3GNT3	B3GNT3	211	0.54	0.5	YES
6	FUT5	FUT5	FUT5	479	0.44	0.56	YES
7	GCNT2	GCNT2	GCNT2	572	0.41	0.62	YES
8	ST3GAL6	ST3GAL6	ST3GAL6	573	0.41	0.68	YES
9	FUT4	FUT4	FUT4	1555	0.26	0.67	YES
10	FUT6	FUT6	FUT6	1669	0.24	0.7	YES
11	FUT7	FUT7	FUT7	1749	0.24	0.74	YES
12	ST3GAL4	ST3GAL4	ST3GAL4	3521	0.13	0.66	NO
13	B4GALT2	B4GALT2	B4GALT2	3893	0.12	0.66	NO
14	B4GALT4	B4GALT4	B4GALT4	5503	0.072	0.58	NO
15	B4GALT3	B4GALT3	B4GALT3	5534	0.072	0.59	NO
16	B3GNT2	B3GNT2	B3GNT2	7896	0.022	0.47	NO
17	B4GALT1	B4GALT1	B4GALT1	8437	0.012	0.44	NO
18	B3GALT2	B3GALT2	B3GALT2	8464	0.011	0.44	NO
19	ST3GAL3	ST3GAL3	ST3GAL3	9194	-0.0023	0.4	NO
20	B3GALT1	B3GALT1	B3GALT1	11301	-0.043	0.29	NO
21	ABO	ABO	ABO	13167	-0.088	0.2	NO
22	FUT2	FUT2	FUT2	13315	-0.093	0.21	NO
23	B3GALT5	B3GALT5	B3GALT5	13706	-0.1	0.2	NO
24	FUT1	FUT1	FUT1	14736	-0.14	0.17	NO
25	B3GNT1	B3GNT1	B3GNT1	14821	-0.14	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IFNG	IFNG	IFNG	682	0.39	0.061	YES
2	PSMB9	PSMB9	PSMB9	2089	0.21	0.038	YES
3	PSMA8	PSMA8	PSMA8	2102	0.21	0.091	YES
4	PSME4	PSME4	PSME4	2328	0.19	0.13	YES
5	SHFM1	SHFM1	SHFM1	2813	0.17	0.14	YES
6	PSMD7	PSMD7	PSMD7	2889	0.16	0.18	YES
7	PSMB2	PSMB2	PSMB2	2911	0.16	0.22	YES
8	PSMA7	PSMA7	PSMA7	3402	0.14	0.23	YES
9	PSMB4	PSMB4	PSMB4	3767	0.12	0.24	YES
10	PSMD14	PSMD14	PSMD14	3951	0.12	0.26	YES
11	PSMD12	PSMD12	PSMD12	4208	0.11	0.28	YES
12	PSMD2	PSMD2	PSMD2	4330	0.1	0.29	YES
13	PSMA4	PSMA4	PSMA4	4596	0.095	0.3	YES
14	PSMC2	PSMC2	PSMC2	4664	0.093	0.32	YES
15	PSMD3	PSMD3	PSMD3	4701	0.092	0.35	YES
16	PSMC1	PSMC1	PSMC1	4750	0.09	0.37	YES
17	PSMA5	PSMA5	PSMA5	4881	0.087	0.38	YES
18	PSMD11	PSMD11	PSMD11	4903	0.086	0.4	YES
19	PSMB8	PSMB8	PSMB8	4943	0.085	0.42	YES
20	PSMC4	PSMC4	PSMC4	5153	0.08	0.43	YES
21	PSMB5	PSMB5	PSMB5	5198	0.079	0.45	YES
22	PSMB7	PSMB7	PSMB7	5253	0.078	0.46	YES
23	PSMB1	PSMB1	PSMB1	5318	0.076	0.48	YES
24	PSMC3	PSMC3	PSMC3	5451	0.073	0.49	YES
25	PSMA2	PSMA2	PSMA2	5517	0.072	0.51	YES
26	PSMA3	PSMA3	PSMA3	5557	0.071	0.52	YES
27	PSMB3	PSMB3	PSMB3	5595	0.07	0.54	YES
28	POMP	POMP	POMP	5668	0.069	0.55	YES
29	PSMD4	PSMD4	PSMD4	5912	0.064	0.56	YES
30	PSMD1	PSMD1	PSMD1	6021	0.061	0.57	YES
31	PSMB6	PSMB6	PSMB6	6107	0.059	0.58	YES
32	PSMD8	PSMD8	PSMD8	6270	0.056	0.58	YES
33	PSMD13	PSMD13	PSMD13	6401	0.053	0.59	YES
34	PSMA1	PSMA1	PSMA1	6712	0.046	0.58	NO
35	PSME2	PSME2	PSME2	7148	0.036	0.57	NO
36	PSMA6	PSMA6	PSMA6	7553	0.028	0.55	NO
37	PSMD6	PSMD6	PSMD6	8507	0.011	0.5	NO
38	PSMF1	PSMF1	PSMF1	9011	0.0011	0.48	NO
39	PSME3	PSME3	PSME3	9143	-0.0013	0.47	NO
40	PSMC5	PSMC5	PSMC5	9483	-0.0081	0.45	NO
41	PSMC6	PSMC6	PSMC6	10113	-0.02	0.42	NO
42	PSME1	PSME1	PSME1	13338	-0.093	0.27	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ATP6V1C2	ATP6V1C2	ATP6V1C2	38	0.7	0.084	YES
2	CXCL1	CXCL1	CXCL1	181	0.56	0.14	YES
3	EGFR	EGFR	EGFR	217	0.54	0.21	YES
4	IL8	IL8	IL8	279	0.51	0.27	YES
5	MET	MET	MET	567	0.41	0.3	YES
6	ATP6V0A4	ATP6V0A4	ATP6V0A4	901	0.34	0.33	YES
7	ATP6V1E2	ATP6V1E2	ATP6V1E2	1073	0.32	0.36	YES
8	LYN	LYN	LYN	1361	0.28	0.38	YES
9	PLCG2	PLCG2	PLCG2	1508	0.26	0.4	YES
10	CCL5	CCL5	CCL5	1523	0.26	0.43	YES
11	PTPRZ1	PTPRZ1	PTPRZ1	1982	0.22	0.44	YES
12	ADAM17	ADAM17	ADAM17	3481	0.14	0.37	NO
13	MAPK12	MAPK12	MAPK12	3867	0.12	0.36	NO
14	HBEGF	HBEGF	HBEGF	3939	0.12	0.37	NO
15	CSK	CSK	CSK	4108	0.11	0.38	NO
16	SRC	SRC	SRC	4754	0.09	0.35	NO
17	F11R	F11R	F11R	4890	0.086	0.36	NO
18	NOD1	NOD1	NOD1	5372	0.075	0.34	NO
19	CASP3	CASP3	CASP3	5650	0.069	0.33	NO
20	ATP6V1F	ATP6V1F	ATP6V1F	5907	0.064	0.33	NO
21	GIT1	GIT1	GIT1	6014	0.061	0.33	NO
22	PLCG1	PLCG1	PLCG1	6475	0.052	0.31	NO
23	MAP3K14	MAP3K14	MAP3K14	6618	0.048	0.31	NO
24	MAPK14	MAPK14	MAPK14	6724	0.046	0.31	NO
25	ATP6V1B2	ATP6V1B2	ATP6V1B2	7108	0.037	0.29	NO
26	IKBKG	IKBKG	IKBKG	7504	0.029	0.27	NO
27	ATP6V0D2	ATP6V0D2	ATP6V0D2	7565	0.028	0.27	NO
28	ATP6V0A2	ATP6V0A2	ATP6V0A2	7596	0.028	0.28	NO
29	ATP6V0B	ATP6V0B	ATP6V0B	7598	0.028	0.28	NO
30	ATP6V0D1	ATP6V0D1	ATP6V0D1	7768	0.024	0.27	NO
31	RELA	RELA	RELA	7778	0.024	0.27	NO
32	RAC1	RAC1	RAC1	8126	0.018	0.26	NO
33	IGSF5	IGSF5	IGSF5	8141	0.017	0.26	NO
34	PTPN11	PTPN11	PTPN11	8296	0.014	0.25	NO
35	MAPK13	MAPK13	MAPK13	8519	0.01	0.24	NO
36	MAPK11	MAPK11	MAPK11	9010	0.0011	0.22	NO
37	ATP6V1A	ATP6V1A	ATP6V1A	9034	0.00073	0.21	NO
38	MAPK8	MAPK8	MAPK8	9146	-0.0013	0.21	NO
39	ATP6V1E1	ATP6V1E1	ATP6V1E1	9229	-0.0032	0.2	NO
40	MAPK10	MAPK10	MAPK10	9316	-0.005	0.2	NO
41	TCIRG1	TCIRG1	TCIRG1	9466	-0.0078	0.19	NO
42	NFKBIA	NFKBIA	NFKBIA	9533	-0.0088	0.19	NO
43	CHUK	CHUK	CHUK	10022	-0.018	0.16	NO
44	CDC42	CDC42	CDC42	10026	-0.018	0.17	NO
45	PAK1	PAK1	PAK1	10197	-0.021	0.16	NO
46	JUN	JUN	JUN	10221	-0.022	0.16	NO
47	NFKB1	NFKB1	NFKB1	10363	-0.025	0.16	NO
48	CXCR2	CXCR2	CXCR2	10894	-0.035	0.13	NO
49	ATP6V1C1	ATP6V1C1	ATP6V1C1	10935	-0.036	0.13	NO
50	ADAM10	ADAM10	ADAM10	10976	-0.036	0.14	NO
51	ATP6V0C	ATP6V0C	ATP6V0C	11016	-0.037	0.14	NO
52	ATP6V1D	ATP6V1D	ATP6V1D	11184	-0.04	0.14	NO
53	TJP1	TJP1	TJP1	11313	-0.043	0.13	NO
54	ATP6V1H	ATP6V1H	ATP6V1H	11495	-0.047	0.13	NO
55	ATP6V1G1	ATP6V1G1	ATP6V1G1	12219	-0.063	0.097	NO
56	ATP6V0E2	ATP6V0E2	ATP6V0E2	12867	-0.08	0.071	NO
57	ATP6AP1	ATP6AP1	ATP6AP1	12899	-0.081	0.08	NO
58	MAPK9	MAPK9	MAPK9	13498	-0.098	0.059	NO
59	ATP6V0A1	ATP6V0A1	ATP6V0A1	13553	-0.099	0.068	NO
60	MAP2K4	MAP2K4	MAP2K4	14418	-0.13	0.037	NO
61	ATP6V1B1	ATP6V1B1	ATP6V1B1	14431	-0.13	0.052	NO
62	CXCR1	CXCR1	CXCR1	15152	-0.16	0.032	NO
63	JAM3	JAM3	JAM3	15632	-0.18	0.028	NO
64	IKBKB	IKBKB	IKBKB	15932	-0.2	0.037	NO
65	JAM2	JAM2	JAM2	16427	-0.24	0.04	NO
66	ATP6V1G2	ATP6V1G2	ATP6V1G2	17845	-0.5	0.024	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCNE1	CCNE1	CCNE1	4	0.88	0.17	YES
2	CDC25A	CDC25A	CDC25A	190	0.56	0.26	YES
3	CDKN2A	CDKN2A	CDKN2A	400	0.46	0.34	YES
4	SKP2	SKP2	SKP2	649	0.39	0.4	YES
5	CDK6	CDK6	CDK6	709	0.38	0.47	YES
6	CCNA1	CCNA1	CCNA1	965	0.33	0.52	YES
7	CDK1	CDK1	CDK1	1374	0.28	0.55	YES
8	TFDP1	TFDP1	TFDP1	3280	0.14	0.47	NO
9	CDK4	CDK4	CDK4	4235	0.11	0.44	NO
10	TGFB2	TGFB2	TGFB2	4818	0.088	0.43	NO
11	CDK2	CDK2	CDK2	5278	0.077	0.42	NO
12	CDKN2B	CDKN2B	CDKN2B	5502	0.072	0.42	NO
13	DHFR	DHFR	DHFR	7211	0.035	0.33	NO
14	ATR	ATR	ATR	7611	0.028	0.31	NO
15	GSK3B	GSK3B	GSK3B	8025	0.02	0.3	NO
16	HDAC1	HDAC1	HDAC1	8117	0.018	0.29	NO
17	ATM	ATM	ATM	10312	-0.024	0.18	NO
18	ABL1	ABL1	ABL1	10444	-0.026	0.18	NO
19	TP53	TP53	TP53	11129	-0.039	0.14	NO
20	SMAD4	SMAD4	SMAD4	11672	-0.051	0.12	NO
21	TGFB1	TGFB1	TGFB1	12651	-0.074	0.086	NO
22	CDKN1A	CDKN1A	CDKN1A	12820	-0.079	0.092	NO
23	CDKN1B	CDKN1B	CDKN1B	14036	-0.12	0.047	NO
24	RB1	RB1	RB1	15123	-0.16	0.018	NO
25	SMAD3	SMAD3	SMAD3	15476	-0.18	0.032	NO
26	TGFB3	TGFB3	TGFB3	16933	-0.3	0.0091	NO
27	CCND1	CCND1	CCND1	17209	-0.34	0.058	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EGFR	EGFR	EGFR	217	0.54	0.073	YES
2	MMP1	MMP1	MMP1	269	0.52	0.15	YES
3	IL8	IL8	IL8	279	0.51	0.23	YES
4	E2F2	E2F2	E2F2	348	0.48	0.3	YES
5	CDKN2A	CDKN2A	CDKN2A	400	0.46	0.38	YES
6	DAPK1	DAPK1	DAPK1	883	0.34	0.4	YES
7	E2F3	E2F3	E2F3	1383	0.28	0.42	YES
8	MMP9	MMP9	MMP9	1391	0.28	0.46	YES
9	VEGFA	VEGFA	VEGFA	2807	0.17	0.41	NO
10	CDK4	CDK4	CDK4	4235	0.11	0.35	NO
11	MYC	MYC	MYC	4309	0.1	0.36	NO
12	TYMP	TYMP	TYMP	4415	0.1	0.37	NO
13	MAP2K1	MAP2K1	MAP2K1	6271	0.056	0.28	NO
14	NRAS	NRAS	NRAS	6685	0.047	0.26	NO
15	MAP2K2	MAP2K2	MAP2K2	6986	0.04	0.25	NO
16	HRAS	HRAS	HRAS	7176	0.036	0.25	NO
17	RAF1	RAF1	RAF1	7486	0.03	0.24	NO
18	CDH1	CDH1	CDH1	7591	0.028	0.24	NO
19	MAPK1	MAPK1	MAPK1	8012	0.02	0.22	NO
20	KRAS	KRAS	KRAS	8411	0.012	0.2	NO
21	DAPK3	DAPK3	DAPK3	8799	0.005	0.18	NO
22	RASSF1	RASSF1	RASSF1	8858	0.0039	0.17	NO
23	PGF	PGF	PGF	8923	0.0028	0.17	NO
24	ERBB2	ERBB2	ERBB2	8975	0.0018	0.17	NO
25	BRAF	BRAF	BRAF	9078	2e-05	0.16	NO
26	DAPK2	DAPK2	DAPK2	10283	-0.023	0.099	NO
27	VEGFB	VEGFB	VEGFB	10334	-0.024	0.1	NO
28	ARAF	ARAF	ARAF	10741	-0.032	0.083	NO
29	TP53	TP53	TP53	11129	-0.039	0.068	NO
30	MMP2	MMP2	MMP2	11606	-0.05	0.05	NO
31	VEGFC	VEGFC	VEGFC	11756	-0.053	0.05	NO
32	CDKN1A	CDKN1A	CDKN1A	12820	-0.079	0.0041	NO
33	THBS1	THBS1	THBS1	13662	-0.1	-0.026	NO
34	MAPK3	MAPK3	MAPK3	13922	-0.11	-0.022	NO
35	MDM2	MDM2	MDM2	14430	-0.13	-0.03	NO
36	RB1	RB1	RB1	15123	-0.16	-0.043	NO
37	FIGF	FIGF	FIGF	15525	-0.18	-0.037	NO
38	EGF	EGF	EGF	15739	-0.19	-0.018	NO
39	RPS6KA5	RPS6KA5	RPS6KA5	16513	-0.25	-0.02	NO
40	CCND1	CCND1	CCND1	17209	-0.34	-0.0052	NO
41	FGFR3	FGFR3	FGFR3	17546	-0.4	0.04	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCNE1	CCNE1	CCNE1	4	0.88	0.3	YES
2	CDK6	CDK6	CDK6	709	0.38	0.38	YES
3	TFDP1	TFDP1	TFDP1	3280	0.14	0.29	NO
4	CDK4	CDK4	CDK4	4235	0.11	0.28	NO
5	CDK2	CDK2	CDK2	5278	0.077	0.25	NO
6	PIK3CA	PIK3CA	PIK3CA	6235	0.056	0.21	NO
7	HRAS	HRAS	HRAS	7176	0.036	0.17	NO
8	RAF1	RAF1	RAF1	7486	0.03	0.17	NO
9	IKBKG	IKBKG	IKBKG	7504	0.029	0.18	NO
10	RELA	RELA	RELA	7778	0.024	0.17	NO
11	MAPK1	MAPK1	MAPK1	8012	0.02	0.16	NO
12	RAC1	RAC1	RAC1	8126	0.018	0.16	NO
13	AKT1	AKT1	AKT1	9353	-0.0059	0.097	NO
14	NFKBIA	NFKBIA	NFKBIA	9533	-0.0088	0.09	NO
15	CHUK	CHUK	CHUK	10022	-0.018	0.069	NO
16	PAK1	PAK1	PAK1	10197	-0.021	0.067	NO
17	RHOA	RHOA	RHOA	10252	-0.023	0.071	NO
18	NFKB1	NFKB1	NFKB1	10363	-0.025	0.074	NO
19	PIK3R1	PIK3R1	PIK3R1	12108	-0.06	-0.0016	NO
20	CDKN1A	CDKN1A	CDKN1A	12820	-0.079	-0.014	NO
21	MAPK3	MAPK3	MAPK3	13922	-0.11	-0.037	NO
22	CDKN1B	CDKN1B	CDKN1B	14036	-0.12	-0.0042	NO
23	RB1	RB1	RB1	15123	-0.16	-0.01	NO
24	IKBKB	IKBKB	IKBKB	15932	-0.2	0.015	NO
25	CCND1	CCND1	CCND1	17209	-0.34	0.058	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPA4	RPA4	RPA4	918	0.34	0.022	YES
2	RFC4	RFC4	RFC4	1472	0.27	0.049	YES
3	DNA2	DNA2	DNA2	1497	0.26	0.1	YES
4	RNASEH1	RNASEH1	RNASEH1	1753	0.24	0.14	YES
5	PRIM2	PRIM2	PRIM2	1895	0.22	0.18	YES
6	MCM2	MCM2	MCM2	1977	0.22	0.22	YES
7	MCM5	MCM5	MCM5	2036	0.21	0.27	YES
8	MCM4	MCM4	MCM4	2100	0.21	0.31	YES
9	MCM7	MCM7	MCM7	2121	0.21	0.35	YES
10	MCM6	MCM6	MCM6	2196	0.2	0.39	YES
11	FEN1	FEN1	FEN1	2263	0.2	0.43	YES
12	POLE2	POLE2	POLE2	2541	0.18	0.45	YES
13	RFC3	RFC3	RFC3	2570	0.18	0.49	YES
14	RFC2	RFC2	RFC2	2796	0.17	0.51	YES
15	POLD1	POLD1	POLD1	2900	0.16	0.54	YES
16	RNASEH2A	RNASEH2A	RNASEH2A	3302	0.14	0.55	YES
17	MCM3	MCM3	MCM3	3307	0.14	0.58	YES
18	POLA2	POLA2	POLA2	3915	0.12	0.57	YES
19	PCNA	PCNA	PCNA	3962	0.12	0.59	YES
20	SSBP1	SSBP1	SSBP1	4451	0.099	0.59	NO
21	POLD3	POLD3	POLD3	4711	0.091	0.59	NO
22	POLD2	POLD2	POLD2	5170	0.08	0.59	NO
23	RPA1	RPA1	RPA1	6055	0.06	0.55	NO
24	POLE3	POLE3	POLE3	6355	0.054	0.55	NO
25	POLE4	POLE4	POLE4	6544	0.05	0.55	NO
26	POLE	POLE	POLE	6773	0.045	0.54	NO
27	RFC5	RFC5	RFC5	6793	0.044	0.55	NO
28	RPA2	RPA2	RPA2	7273	0.034	0.53	NO
29	RNASEH2B	RNASEH2B	RNASEH2B	7407	0.031	0.53	NO
30	LIG1	LIG1	LIG1	7464	0.03	0.54	NO
31	PRIM1	PRIM1	PRIM1	7699	0.026	0.53	NO
32	RPA3	RPA3	RPA3	8846	0.0041	0.47	NO
33	RNASEH2C	RNASEH2C	RNASEH2C	9804	-0.014	0.42	NO
34	RFC1	RFC1	RFC1	11701	-0.052	0.32	NO
35	POLD4	POLD4	POLD4	15429	-0.17	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RAD54L	RAD54L	RAD54L	307	0.5	0.1	YES
2	BLM	BLM	BLM	713	0.38	0.17	YES
3	RAD51	RAD51	RAD51	789	0.36	0.25	YES
4	XRCC2	XRCC2	XRCC2	831	0.35	0.33	YES
5	RPA4	RPA4	RPA4	918	0.34	0.4	YES
6	EME1	EME1	EME1	1153	0.31	0.46	YES
7	RAD54B	RAD54B	RAD54B	1612	0.25	0.49	YES
8	BRCA2	BRCA2	BRCA2	1828	0.23	0.53	YES
9	SHFM1	SHFM1	SHFM1	2813	0.17	0.52	YES
10	POLD1	POLD1	POLD1	2900	0.16	0.55	YES
11	RAD51L1	RAD51L1	RAD51L1	3036	0.16	0.58	YES
12	SSBP1	SSBP1	SSBP1	4451	0.099	0.53	NO
13	TOP3B	TOP3B	TOP3B	4622	0.094	0.54	NO
14	POLD3	POLD3	POLD3	4711	0.091	0.56	NO
15	XRCC3	XRCC3	XRCC3	4797	0.089	0.57	NO
16	POLD2	POLD2	POLD2	5170	0.08	0.57	NO
17	RPA1	RPA1	RPA1	6055	0.06	0.54	NO
18	MRE11A	MRE11A	MRE11A	6134	0.059	0.55	NO
19	RPA2	RPA2	RPA2	7273	0.034	0.49	NO
20	MUS81	MUS81	MUS81	7505	0.029	0.48	NO
21	TOP3A	TOP3A	TOP3A	7729	0.025	0.48	NO
22	RPA3	RPA3	RPA3	8846	0.0041	0.42	NO
23	NBN	NBN	NBN	8939	0.0025	0.41	NO
24	RAD51L3	RAD51L3	RAD51L3	11163	-0.04	0.3	NO
25	RAD52	RAD52	RAD52	11410	-0.045	0.3	NO
26	RAD50	RAD50	RAD50	15211	-0.16	0.13	NO
27	POLD4	POLD4	POLD4	15429	-0.17	0.16	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA NO1 PATHWAY	27	genes.ES.table	0.52	1.3	0.14	0.18	0.98	0.56	0.32	0.38	0.14	0
BIOCARTA AGR PATHWAY	35	genes.ES.table	0.67	1.9	0.0041	0.08	0.14	0.23	0.064	0.21	0	0.023
BIOCARTA ALK PATHWAY	34	genes.ES.table	0.56	1.6	0.0081	0.07	0.64	0.44	0.27	0.32	0.038	0
BIOCARTA AT1R PATHWAY	32	genes.ES.table	0.45	1.7	0.02	0.064	0.52	0.25	0.27	0.18	0.028	0
BIOCARTA BCR PATHWAY	33	genes.ES.table	0.57	1.7	0.028	0.068	0.61	0.33	0.22	0.26	0.034	0
BIOCARTA BIOPEPTIDES PATHWAY	39	genes.ES.table	0.46	1.6	0.018	0.071	0.68	0.41	0.35	0.27	0.04	0
BIOCARTA HDAC PATHWAY	26	genes.ES.table	0.46	1.4	0.11	0.12	0.92	0.38	0.3	0.27	0.084	0
BIOCARTA EGF PATHWAY	30	genes.ES.table	0.57	1.7	0.0042	0.059	0.42	0.33	0.2	0.27	0	0
BIOCARTA ERK PATHWAY	27	genes.ES.table	0.51	1.7	0.023	0.065	0.5	0.15	0.094	0.13	0.028	0
BIOCARTA FCER1 PATHWAY	37	genes.ES.table	0.6	1.8	0	0.053	0.37	0.32	0.22	0.26	0	0

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PAK7	PAK7	PAK7	13	0.92	0.12	YES
2	FIGF	FIGF	FIGF	28	0.84	0.23	YES
3	HGF	HGF	HGF	639	0.46	0.26	YES
4	PAK3	PAK3	PAK3	974	0.39	0.29	YES
5	MET	MET	MET	1249	0.35	0.32	YES
6	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.31	YES
7	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.34	YES
8	TGFB3	TGFB3	TGFB3	2290	0.25	0.37	YES
9	TGFB2	TGFB2	TGFB2	2648	0.22	0.38	YES
10	AKT3	AKT3	AKT3	2691	0.22	0.4	YES
11	PGF	PGF	PGF	2820	0.21	0.42	YES
12	EPAS1	EPAS1	EPAS1	2831	0.21	0.45	YES
13	VEGFC	VEGFC	VEGFC	2890	0.21	0.48	YES
14	JUN	JUN	JUN	3155	0.19	0.49	YES
15	ETS1	ETS1	ETS1	3181	0.19	0.51	YES
16	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.53	YES
17	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.54	YES
18	TGFB1	TGFB1	TGFB1	4693	0.13	0.49	NO
19	TGFA	TGFA	TGFA	5596	0.096	0.46	NO
20	GAB1	GAB1	GAB1	6001	0.085	0.44	NO
21	RAPGEF1	RAPGEF1	RAPGEF1	6425	0.074	0.43	NO
22	ARNT2	ARNT2	ARNT2	6526	0.072	0.44	NO
23	VEGFB	VEGFB	VEGFB	7573	0.051	0.38	NO
24	FLCN	FLCN	FLCN	7614	0.05	0.39	NO
25	SOS2	SOS2	SOS2	7768	0.048	0.39	NO
26	EGLN2	EGLN2	EGLN2	8057	0.043	0.38	NO
27	CREBBP	CREBBP	CREBBP	8437	0.037	0.36	NO
28	EGLN3	EGLN3	EGLN3	8739	0.033	0.35	NO
29	ARNT	ARNT	ARNT	8756	0.032	0.35	NO
30	RAP1A	RAP1A	RAP1A	9079	0.028	0.34	NO
31	PAK6	PAK6	PAK6	9450	0.022	0.32	NO
32	CRK	CRK	CRK	9503	0.022	0.32	NO
33	RAP1B	RAP1B	RAP1B	9799	0.018	0.31	NO
34	ARAF	ARAF	ARAF	9948	0.016	0.3	NO
35	PDGFB	PDGFB	PDGFB	9949	0.016	0.3	NO
36	CDC42	CDC42	CDC42	10069	0.015	0.3	NO
37	EP300	EP300	EP300	10210	0.013	0.29	NO
38	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.29	NO
39	AKT2	AKT2	AKT2	10283	0.012	0.29	NO
40	MAPK3	MAPK3	MAPK3	10431	0.0097	0.28	NO
41	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.28	NO
42	SOS1	SOS1	SOS1	10755	0.006	0.27	NO
43	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.22	NO
44	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.22	NO
45	VHL	VHL	VHL	11806	-0.0065	0.21	NO
46	CRKL	CRKL	CRKL	11863	-0.0071	0.21	NO
47	PAK1	PAK1	PAK1	11875	-0.0072	0.21	NO
48	RAC1	RAC1	RAC1	12463	-0.015	0.18	NO
49	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.18	NO
50	RAF1	RAF1	RAF1	12740	-0.018	0.17	NO
51	HIF1A	HIF1A	HIF1A	12763	-0.018	0.17	NO
52	AKT1	AKT1	AKT1	12834	-0.019	0.17	NO
53	NRAS	NRAS	NRAS	13027	-0.022	0.16	NO
54	PAK2	PAK2	PAK2	13210	-0.024	0.16	NO
55	GRB2	GRB2	GRB2	13272	-0.025	0.16	NO
56	KRAS	KRAS	KRAS	13800	-0.032	0.13	NO
57	PAK4	PAK4	PAK4	13812	-0.033	0.13	NO
58	PTPN11	PTPN11	PTPN11	14006	-0.036	0.13	NO
59	EGLN1	EGLN1	EGLN1	14223	-0.039	0.12	NO
60	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.13	NO
61	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.099	NO
62	TCEB2	TCEB2	TCEB2	14923	-0.051	0.1	NO
63	BRAF	BRAF	BRAF	15055	-0.053	0.1	NO
64	CUL2	CUL2	CUL2	15557	-0.063	0.082	NO
65	RBX1	RBX1	RBX1	15606	-0.064	0.088	NO
66	FH	FH	FH	15982	-0.073	0.077	NO
67	VEGFA	VEGFA	VEGFA	16764	-0.1	0.048	NO
68	SLC2A1	SLC2A1	SLC2A1	16926	-0.11	0.053	NO
69	TCEB1	TCEB1	TCEB1	17510	-0.16	0.042	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CALML3	CALML3	CALML3	171	0.67	0.037	YES
2	PYGM	PYGM	PYGM	186	0.66	0.081	YES
3	PCK1	PCK1	PCK1	253	0.62	0.12	YES
4	SLC2A4	SLC2A4	SLC2A4	308	0.59	0.16	YES
5	LIPE	LIPE	LIPE	314	0.58	0.2	YES
6	SOCS2	SOCS2	SOCS2	476	0.51	0.22	YES
7	PHKG1	PHKG1	PHKG1	622	0.46	0.25	YES
8	ACACB	ACACB	ACACB	822	0.42	0.27	YES
9	PDE3B	PDE3B	PDE3B	1073	0.37	0.28	YES
10	GCK	GCK	GCK	1172	0.36	0.3	YES
11	GYS2	GYS2	GYS2	1362	0.33	0.31	YES
12	SORBS1	SORBS1	SORBS1	1442	0.32	0.33	YES
13	PPARGC1A	PPARGC1A	PPARGC1A	1539	0.31	0.34	YES
14	FOXO1	FOXO1	FOXO1	1949	0.28	0.34	YES
15	SHC2	SHC2	SHC2	1951	0.28	0.36	YES
16	INPP5D	INPP5D	INPP5D	2088	0.26	0.37	YES
17	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.38	YES
18	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.4	YES
19	PDE3A	PDE3A	PDE3A	2288	0.25	0.41	YES
20	G6PC2	G6PC2	G6PC2	2346	0.24	0.42	YES
21	SOCS3	SOCS3	SOCS3	2463	0.23	0.44	YES
22	PPP1R3C	PPP1R3C	PPP1R3C	2547	0.23	0.45	YES
23	AKT3	AKT3	AKT3	2691	0.22	0.45	YES
24	IRS1	IRS1	IRS1	2837	0.21	0.46	YES
25	IRS2	IRS2	IRS2	2847	0.21	0.47	YES
26	MAPK10	MAPK10	MAPK10	2930	0.21	0.48	YES
27	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.47	YES
28	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.47	YES
29	SHC4	SHC4	SHC4	3817	0.16	0.47	YES
30	PRKAA2	PRKAA2	PRKAA2	3897	0.16	0.48	YES
31	SOCS1	SOCS1	SOCS1	3951	0.16	0.48	YES
32	PPP1R3B	PPP1R3B	PPP1R3B	4447	0.14	0.47	NO
33	FBP1	FBP1	FBP1	4606	0.13	0.47	NO
34	PRKAR1B	PRKAR1B	PRKAR1B	4737	0.13	0.47	NO
35	PRKAR2B	PRKAR2B	PRKAR2B	4864	0.12	0.47	NO
36	IRS4	IRS4	IRS4	5309	0.1	0.45	NO
37	PRKAA1	PRKAA1	PRKAA1	5342	0.1	0.46	NO
38	CALML6	CALML6	CALML6	5460	0.1	0.46	NO
39	CBLC	CBLC	CBLC	5776	0.091	0.45	NO
40	PRKACB	PRKACB	PRKACB	5859	0.089	0.45	NO
41	TRIP10	TRIP10	TRIP10	5870	0.088	0.46	NO
42	RAPGEF1	RAPGEF1	RAPGEF1	6425	0.074	0.43	NO
43	MKNK2	MKNK2	MKNK2	6649	0.069	0.42	NO
44	IKBKB	IKBKB	IKBKB	7005	0.061	0.41	NO
45	TSC1	TSC1	TSC1	7195	0.057	0.4	NO
46	RPS6	RPS6	RPS6	7220	0.057	0.4	NO
47	INPP5K	INPP5K	INPP5K	7296	0.056	0.4	NO
48	SOS2	SOS2	SOS2	7768	0.048	0.38	NO
49	RHOQ	RHOQ	RHOQ	7825	0.047	0.38	NO
50	PRKAB1	PRKAB1	PRKAB1	7951	0.045	0.38	NO
51	CBL	CBL	CBL	7991	0.044	0.38	NO
52	MKNK1	MKNK1	MKNK1	8075	0.042	0.38	NO
53	INSR	INSR	INSR	8442	0.037	0.36	NO
54	PRKAG2	PRKAG2	PRKAG2	8840	0.031	0.34	NO
55	PHKA2	PHKA2	PHKA2	9086	0.027	0.33	NO
56	CBLB	CBLB	CBLB	9134	0.027	0.33	NO
57	SHC1	SHC1	SHC1	9164	0.026	0.33	NO
58	BAD	BAD	BAD	9341	0.024	0.32	NO
59	PRKAB2	PRKAB2	PRKAB2	9461	0.022	0.31	NO
60	CRK	CRK	CRK	9503	0.022	0.31	NO
61	PRKAR2A	PRKAR2A	PRKAR2A	9528	0.022	0.31	NO
62	PRKX	PRKX	PRKX	9800	0.018	0.3	NO
63	ARAF	ARAF	ARAF	9948	0.016	0.29	NO
64	TSC2	TSC2	TSC2	10041	0.015	0.29	NO
65	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.28	NO
66	PRKCZ	PRKCZ	PRKCZ	10238	0.012	0.28	NO
67	AKT2	AKT2	AKT2	10283	0.012	0.28	NO
68	MAPK3	MAPK3	MAPK3	10431	0.0097	0.27	NO
69	MAPK8	MAPK8	MAPK8	10593	0.0079	0.26	NO
70	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.26	NO
71	PDPK1	PDPK1	PDPK1	10675	0.0069	0.26	NO
72	EXOC7	EXOC7	EXOC7	10719	0.0064	0.26	NO
73	SOS1	SOS1	SOS1	10755	0.006	0.26	NO
74	PRKAR1A	PRKAR1A	PRKAR1A	10855	0.005	0.25	NO
75	FASN	FASN	FASN	10930	0.0041	0.25	NO
76	FLOT2	FLOT2	FLOT2	11026	0.0028	0.24	NO
77	FLOT1	FLOT1	FLOT1	11109	0.0019	0.24	NO
78	PYGL	PYGL	PYGL	11294	-0.00016	0.23	NO
79	MTOR	MTOR	MTOR	11444	-0.0022	0.22	NO
80	PKLR	PKLR	PKLR	11503	-0.0027	0.22	NO
81	HK1	HK1	HK1	11548	-0.0034	0.21	NO
82	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.21	NO
83	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.2	NO
84	CALM3	CALM3	CALM3	11748	-0.0059	0.2	NO
85	PRKACA	PRKACA	PRKACA	11771	-0.0062	0.2	NO
86	CRKL	CRKL	CRKL	11863	-0.0071	0.2	NO
87	FBP2	FBP2	FBP2	11870	-0.0072	0.2	NO
88	PTPRF	PTPRF	PTPRF	11951	-0.0083	0.19	NO
89	PHKB	PHKB	PHKB	12336	-0.013	0.17	NO
90	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.16	NO
91	RPTOR	RPTOR	RPTOR	12560	-0.016	0.16	NO
92	SOCS4	SOCS4	SOCS4	12574	-0.016	0.16	NO
93	EIF4E2	EIF4E2	EIF4E2	12681	-0.017	0.16	NO
94	RAF1	RAF1	RAF1	12740	-0.018	0.16	NO
95	AKT1	AKT1	AKT1	12834	-0.019	0.15	NO
96	PPP1CB	PPP1CB	PPP1CB	12964	-0.021	0.15	NO
97	NRAS	NRAS	NRAS	13027	-0.022	0.15	NO
98	PYGB	PYGB	PYGB	13032	-0.022	0.15	NO
99	GYS1	GYS1	GYS1	13110	-0.023	0.14	NO
100	PHKG2	PHKG2	PHKG2	13162	-0.024	0.14	NO
101	PPP1CC	PPP1CC	PPP1CC	13257	-0.025	0.14	NO
102	GRB2	GRB2	GRB2	13272	-0.025	0.14	NO
103	MAPK9	MAPK9	MAPK9	13385	-0.027	0.14	NO
104	CALML5	CALML5	CALML5	13621	-0.03	0.13	NO
105	CALM1	CALM1	CALM1	13625	-0.03	0.13	NO
106	RPS6KB1	RPS6KB1	RPS6KB1	13662	-0.031	0.13	NO
107	ELK1	ELK1	ELK1	13692	-0.031	0.13	NO
108	PRKAG1	PRKAG1	PRKAG1	13724	-0.031	0.13	NO
109	KRAS	KRAS	KRAS	13800	-0.032	0.13	NO
110	SH2B2	SH2B2	SH2B2	13826	-0.033	0.13	NO
111	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.11	NO
112	EIF4E	EIF4E	EIF4E	14285	-0.04	0.11	NO
113	CALM2	CALM2	CALM2	14511	-0.043	0.099	NO
114	SREBF1	SREBF1	SREBF1	14515	-0.043	0.1	NO
115	PCK2	PCK2	PCK2	14698	-0.047	0.095	NO
116	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.09	NO
117	BRAF	BRAF	BRAF	15055	-0.053	0.082	NO
118	ACACA	ACACA	ACACA	15172	-0.055	0.08	NO
119	GSK3B	GSK3B	GSK3B	15298	-0.058	0.077	NO
120	PRKCI	PRKCI	PRKCI	15349	-0.058	0.078	NO
121	PPP1CA	PPP1CA	PPP1CA	15406	-0.059	0.079	NO
122	PTPN1	PTPN1	PTPN1	15507	-0.061	0.078	NO
123	HK2	HK2	HK2	15729	-0.067	0.07	NO
124	SHC3	SHC3	SHC3	15824	-0.069	0.07	NO
125	RPS6KB2	RPS6KB2	RPS6KB2	15873	-0.07	0.072	NO
126	PPP1R3D	PPP1R3D	PPP1R3D	15962	-0.072	0.072	NO
127	RHEB	RHEB	RHEB	16207	-0.08	0.064	NO
128	PHKA1	PHKA1	PHKA1	16786	-0.1	0.039	NO
129	HK3	HK3	HK3	17440	-0.15	0.014	NO
130	EIF4E1B	EIF4E1B	EIF4E1B	17456	-0.15	0.023	NO
131	PRKAG3	PRKAG3	PRKAG3	17481	-0.15	0.032	NO
132	EIF4EBP1	EIF4EBP1	EIF4EBP1	17580	-0.17	0.038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NGFR	NGFR	NGFR	71	0.77	0.056	YES
2	CALML3	CALML3	CALML3	171	0.67	0.1	YES
3	NTF4	NTF4	NTF4	294	0.6	0.14	YES
4	NTRK3	NTRK3	NTRK3	344	0.56	0.18	YES
5	NTRK2	NTRK2	NTRK2	471	0.51	0.22	YES
6	IRAK3	IRAK3	IRAK3	1007	0.38	0.22	YES
7	CAMK4	CAMK4	CAMK4	1390	0.33	0.22	YES
8	NTRK1	NTRK1	NTRK1	1520	0.32	0.24	YES
9	NGF	NGF	NGF	1713	0.3	0.25	YES
10	NTF3	NTF3	NTF3	1946	0.28	0.26	YES
11	SHC2	SHC2	SHC2	1951	0.28	0.28	YES
12	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.29	YES
13	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.31	YES
14	AKT3	AKT3	AKT3	2691	0.22	0.3	YES
15	IRS1	IRS1	IRS1	2837	0.21	0.31	YES
16	IRS2	IRS2	IRS2	2847	0.21	0.32	YES
17	MAPK10	MAPK10	MAPK10	2930	0.21	0.33	YES
18	RPS6KA2	RPS6KA2	RPS6KA2	3109	0.2	0.34	YES
19	JUN	JUN	JUN	3155	0.19	0.35	YES
20	PLCG2	PLCG2	PLCG2	3169	0.19	0.37	YES
21	FASLG	FASLG	FASLG	3256	0.19	0.38	YES
22	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.39	YES
23	IRAK2	IRAK2	IRAK2	3349	0.18	0.4	YES
24	BCL2	BCL2	BCL2	3413	0.18	0.41	YES
25	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.42	YES
26	MAP3K1	MAP3K1	MAP3K1	3622	0.17	0.43	YES
27	MAPK11	MAPK11	MAPK11	3638	0.17	0.44	YES
28	RPS6KA3	RPS6KA3	RPS6KA3	3811	0.16	0.44	YES
29	SHC4	SHC4	SHC4	3817	0.16	0.46	YES
30	BDNF	BDNF	BDNF	4310	0.14	0.44	NO
31	RPS6KA5	RPS6KA5	RPS6KA5	4469	0.14	0.44	NO
32	CAMK2A	CAMK2A	CAMK2A	4831	0.12	0.43	NO
33	TP73	TP73	TP73	4971	0.12	0.43	NO
34	SH2B3	SH2B3	SH2B3	5175	0.11	0.43	NO
35	MAP3K3	MAP3K3	MAP3K3	5249	0.11	0.43	NO
36	IRS4	IRS4	IRS4	5309	0.1	0.44	NO
37	CAMK2D	CAMK2D	CAMK2D	5329	0.1	0.44	NO
38	ARHGDIB	ARHGDIB	ARHGDIB	5406	0.1	0.45	NO
39	CALML6	CALML6	CALML6	5460	0.1	0.45	NO
40	MAP3K5	MAP3K5	MAP3K5	5750	0.091	0.44	NO
41	GAB1	GAB1	GAB1	6001	0.085	0.44	NO
42	MAP2K5	MAP2K5	MAP2K5	6171	0.08	0.44	NO
43	CAMK2B	CAMK2B	CAMK2B	6405	0.075	0.43	NO
44	RAPGEF1	RAPGEF1	RAPGEF1	6425	0.074	0.43	NO
45	RPS6KA6	RPS6KA6	RPS6KA6	6563	0.071	0.43	NO
46	NFKBIA	NFKBIA	NFKBIA	6624	0.07	0.43	NO
47	ABL1	ABL1	ABL1	6913	0.063	0.42	NO
48	FOXO3	FOXO3	FOXO3	6933	0.063	0.43	NO
49	IKBKB	IKBKB	IKBKB	7005	0.061	0.43	NO
50	NFKB1	NFKB1	NFKB1	7019	0.061	0.43	NO
51	SOS2	SOS2	SOS2	7768	0.048	0.39	NO
52	MAPK7	MAPK7	MAPK7	7802	0.047	0.4	NO
53	FRS2	FRS2	FRS2	7987	0.044	0.39	NO
54	SH2B1	SH2B1	SH2B1	8038	0.043	0.39	NO
55	TRAF6	TRAF6	TRAF6	8249	0.04	0.38	NO
56	NGFRAP1	NGFRAP1	NGFRAP1	8296	0.039	0.38	NO
57	RPS6KA4	RPS6KA4	RPS6KA4	8572	0.035	0.37	NO
58	KIDINS220	KIDINS220	KIDINS220	8597	0.035	0.37	NO
59	ZNF274	ZNF274	ZNF274	8746	0.033	0.36	NO
60	TP53	TP53	TP53	9009	0.029	0.35	NO
61	MAP2K7	MAP2K7	MAP2K7	9010	0.029	0.35	NO
62	RAP1A	RAP1A	RAP1A	9079	0.028	0.35	NO
63	SHC1	SHC1	SHC1	9164	0.026	0.35	NO
64	BAD	BAD	BAD	9341	0.024	0.34	NO
65	IRAK4	IRAK4	IRAK4	9414	0.023	0.34	NO
66	PLCG1	PLCG1	PLCG1	9466	0.022	0.34	NO
67	CRK	CRK	CRK	9503	0.022	0.34	NO
68	RAP1B	RAP1B	RAP1B	9799	0.018	0.32	NO
69	RPS6KA1	RPS6KA1	RPS6KA1	9804	0.018	0.32	NO
70	CDC42	CDC42	CDC42	10069	0.015	0.31	NO
71	PRDM4	PRDM4	PRDM4	10113	0.014	0.31	NO
72	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.3	NO
73	AKT2	AKT2	AKT2	10283	0.012	0.3	NO
74	RELA	RELA	RELA	10411	0.0099	0.3	NO
75	MAPK3	MAPK3	MAPK3	10431	0.0097	0.3	NO
76	MAPK8	MAPK8	MAPK8	10593	0.0079	0.29	NO
77	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.29	NO
78	CSK	CSK	CSK	10622	0.0076	0.29	NO
79	SOS1	SOS1	SOS1	10755	0.006	0.28	NO
80	RHOA	RHOA	RHOA	10938	0.004	0.27	NO
81	CAMK2G	CAMK2G	CAMK2G	11049	0.0026	0.26	NO
82	PSEN1	PSEN1	PSEN1	11507	-0.0028	0.24	NO
83	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.24	NO
84	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.23	NO
85	CALM3	CALM3	CALM3	11748	-0.0059	0.23	NO
86	CRKL	CRKL	CRKL	11863	-0.0071	0.22	NO
87	MAPK14	MAPK14	MAPK14	12103	-0.01	0.21	NO
88	MAPKAPK2	MAPKAPK2	MAPKAPK2	12279	-0.012	0.2	NO
89	RAC1	RAC1	RAC1	12463	-0.015	0.19	NO
90	NFKBIB	NFKBIB	NFKBIB	12468	-0.015	0.19	NO
91	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.19	NO
92	RAF1	RAF1	RAF1	12740	-0.018	0.18	NO
93	AKT1	AKT1	AKT1	12834	-0.019	0.18	NO
94	NRAS	NRAS	NRAS	13027	-0.022	0.17	NO
95	GRB2	GRB2	GRB2	13272	-0.025	0.16	NO
96	NFKBIE	NFKBIE	NFKBIE	13288	-0.025	0.16	NO
97	MAPK9	MAPK9	MAPK9	13385	-0.027	0.16	NO
98	ARHGDIA	ARHGDIA	ARHGDIA	13459	-0.028	0.15	NO
99	YWHAB	YWHAB	YWHAB	13547	-0.029	0.15	NO
100	MAPK12	MAPK12	MAPK12	13560	-0.029	0.15	NO
101	ATF4	ATF4	ATF4	13563	-0.029	0.16	NO
102	CALML5	CALML5	CALML5	13621	-0.03	0.15	NO
103	CALM1	CALM1	CALM1	13625	-0.03	0.16	NO
104	KRAS	KRAS	KRAS	13800	-0.032	0.15	NO
105	SH2B2	SH2B2	SH2B2	13826	-0.033	0.15	NO
106	PTPN11	PTPN11	PTPN11	14006	-0.036	0.14	NO
107	BAX	BAX	BAX	14040	-0.036	0.14	NO
108	SORT1	SORT1	SORT1	14091	-0.037	0.14	NO
109	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.14	NO
110	YWHAH	YWHAH	YWHAH	14299	-0.04	0.14	NO
111	PRKCD	PRKCD	PRKCD	14386	-0.042	0.14	NO
112	MAGED1	MAGED1	MAGED1	14445	-0.042	0.14	NO
113	CALM2	CALM2	CALM2	14511	-0.043	0.14	NO
114	YWHAE	YWHAE	YWHAE	14556	-0.044	0.14	NO
115	YWHAQ	YWHAQ	YWHAQ	14827	-0.049	0.13	NO
116	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.13	NO
117	BRAF	BRAF	BRAF	15055	-0.053	0.12	NO
118	GSK3B	GSK3B	GSK3B	15298	-0.058	0.11	NO
119	MAPK13	MAPK13	MAPK13	15417	-0.06	0.11	NO
120	YWHAG	YWHAG	YWHAG	15682	-0.065	0.1	NO
121	SHC3	SHC3	SHC3	15824	-0.069	0.1	NO
122	IRAK1	IRAK1	IRAK1	15859	-0.07	0.1	NO
123	YWHAZ	YWHAZ	YWHAZ	16886	-0.11	0.056	NO
124	PDK1	PDK1	PDK1	17118	-0.12	0.053	NO
125	RIPK2	RIPK2	RIPK2	17355	-0.14	0.051	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PAK7	PAK7	PAK7	13	0.92	0.096	YES
2	NRG2	NRG2	NRG2	339	0.57	0.14	YES
3	NRG1	NRG1	NRG1	494	0.5	0.18	YES
4	PRKCB	PRKCB	PRKCB	830	0.41	0.2	YES
5	PAK3	PAK3	PAK3	974	0.39	0.24	YES
6	AREG	AREG	AREG	1038	0.38	0.27	YES
7	EGFR	EGFR	EGFR	1176	0.36	0.3	YES
8	PRKCA	PRKCA	PRKCA	1732	0.29	0.3	YES
9	ERBB4	ERBB4	ERBB4	1762	0.29	0.33	YES
10	SHC2	SHC2	SHC2	1951	0.28	0.35	YES
11	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.37	YES
12	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.39	YES
13	AKT3	AKT3	AKT3	2691	0.22	0.39	YES
14	EGF	EGF	EGF	2843	0.21	0.4	YES
15	HBEGF	HBEGF	HBEGF	2852	0.21	0.42	YES
16	MAPK10	MAPK10	MAPK10	2930	0.21	0.44	YES
17	JUN	JUN	JUN	3155	0.19	0.45	YES
18	PLCG2	PLCG2	PLCG2	3169	0.19	0.47	YES
19	STAT5A	STAT5A	STAT5A	3265	0.19	0.48	YES
20	EREG	EREG	EREG	3319	0.19	0.5	YES
21	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.52	YES
22	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.52	YES
23	SHC4	SHC4	SHC4	3817	0.16	0.52	YES
24	STAT5B	STAT5B	STAT5B	4598	0.13	0.49	NO
25	CAMK2A	CAMK2A	CAMK2A	4831	0.12	0.49	NO
26	MYC	MYC	MYC	5154	0.11	0.49	NO
27	CAMK2D	CAMK2D	CAMK2D	5329	0.1	0.49	NO
28	TGFA	TGFA	TGFA	5596	0.096	0.48	NO
29	CBLC	CBLC	CBLC	5776	0.091	0.48	NO
30	GAB1	GAB1	GAB1	6001	0.085	0.48	NO
31	CAMK2B	CAMK2B	CAMK2B	6405	0.075	0.47	NO
32	CDKN1B	CDKN1B	CDKN1B	6605	0.07	0.46	NO
33	ABL1	ABL1	ABL1	6913	0.063	0.45	NO
34	CDKN1A	CDKN1A	CDKN1A	7354	0.055	0.43	NO
35	SOS2	SOS2	SOS2	7768	0.048	0.42	NO
36	CBL	CBL	CBL	7991	0.044	0.41	NO
37	BTC	BTC	BTC	8000	0.044	0.41	NO
38	ERBB3	ERBB3	ERBB3	8594	0.035	0.38	NO
39	NCK2	NCK2	NCK2	8613	0.034	0.39	NO
40	MAP2K7	MAP2K7	MAP2K7	9010	0.029	0.37	NO
41	CBLB	CBLB	CBLB	9134	0.027	0.36	NO
42	SHC1	SHC1	SHC1	9164	0.026	0.36	NO
43	BAD	BAD	BAD	9341	0.024	0.36	NO
44	PAK6	PAK6	PAK6	9450	0.022	0.35	NO
45	PLCG1	PLCG1	PLCG1	9466	0.022	0.36	NO
46	CRK	CRK	CRK	9503	0.022	0.36	NO
47	ABL2	ABL2	ABL2	9766	0.019	0.34	NO
48	ARAF	ARAF	ARAF	9948	0.016	0.34	NO
49	MAP2K4	MAP2K4	MAP2K4	10149	0.014	0.32	NO
50	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.32	NO
51	AKT2	AKT2	AKT2	10283	0.012	0.32	NO
52	MAPK3	MAPK3	MAPK3	10431	0.0097	0.31	NO
53	NRG3	NRG3	NRG3	10442	0.0095	0.31	NO
54	MAPK8	MAPK8	MAPK8	10593	0.0079	0.31	NO
55	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.31	NO
56	SOS1	SOS1	SOS1	10755	0.006	0.3	NO
57	CAMK2G	CAMK2G	CAMK2G	11049	0.0026	0.28	NO
58	MTOR	MTOR	MTOR	11444	-0.0022	0.26	NO
59	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.26	NO
60	NCK1	NCK1	NCK1	11704	-0.0053	0.25	NO
61	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.25	NO
62	CRKL	CRKL	CRKL	11863	-0.0071	0.24	NO
63	PAK1	PAK1	PAK1	11875	-0.0072	0.24	NO
64	ERBB2	ERBB2	ERBB2	12449	-0.014	0.21	NO
65	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.21	NO
66	RAF1	RAF1	RAF1	12740	-0.018	0.2	NO
67	NRG4	NRG4	NRG4	12747	-0.018	0.2	NO
68	AKT1	AKT1	AKT1	12834	-0.019	0.2	NO
69	NRAS	NRAS	NRAS	13027	-0.022	0.19	NO
70	PAK2	PAK2	PAK2	13210	-0.024	0.18	NO
71	GRB2	GRB2	GRB2	13272	-0.025	0.18	NO
72	MAPK9	MAPK9	MAPK9	13385	-0.027	0.18	NO
73	RPS6KB1	RPS6KB1	RPS6KB1	13662	-0.031	0.17	NO
74	ELK1	ELK1	ELK1	13692	-0.031	0.17	NO
75	KRAS	KRAS	KRAS	13800	-0.032	0.16	NO
76	PAK4	PAK4	PAK4	13812	-0.033	0.17	NO
77	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.15	NO
78	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.12	NO
79	BRAF	BRAF	BRAF	15055	-0.053	0.12	NO
80	GSK3B	GSK3B	GSK3B	15298	-0.058	0.11	NO
81	SRC	SRC	SRC	15459	-0.06	0.1	NO
82	SHC3	SHC3	SHC3	15824	-0.069	0.092	NO
83	RPS6KB2	RPS6KB2	RPS6KB2	15873	-0.07	0.097	NO
84	PTK2	PTK2	PTK2	16069	-0.075	0.094	NO
85	PRKCG	PRKCG	PRKCG	16685	-0.098	0.07	NO
86	EIF4EBP1	EIF4EBP1	EIF4EBP1	17580	-0.17	0.038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PAK7	PAK7	PAK7	13	0.92	0.16	YES
2	NRG2	NRG2	NRG2	339	0.57	0.25	YES
3	LAMA2	LAMA2	LAMA2	443	0.52	0.34	YES
4	NRG1	NRG1	NRG1	494	0.5	0.42	YES
5	DMD	DMD	DMD	570	0.47	0.5	YES
6	PAK3	PAK3	PAK3	974	0.39	0.55	YES
7	LAMA3	LAMA3	LAMA3	1092	0.37	0.61	YES
8	EGFR	EGFR	EGFR	1176	0.36	0.67	YES
9	JUN	JUN	JUN	3155	0.19	0.59	NO
10	UTRN	UTRN	UTRN	3543	0.18	0.6	NO
11	CHRM1	CHRM1	CHRM1	4385	0.14	0.58	NO
12	MUSK	MUSK	MUSK	4474	0.14	0.6	NO
13	LAMA4	LAMA4	LAMA4	5340	0.1	0.57	NO
14	ITGA1	ITGA1	ITGA1	5476	0.099	0.58	NO
15	GIT2	GIT2	GIT2	7422	0.054	0.49	NO
16	PXN	PXN	PXN	7527	0.052	0.49	NO
17	SP1	SP1	SP1	8964	0.029	0.42	NO
18	PAK6	PAK6	PAK6	9450	0.022	0.4	NO
19	ITGB1	ITGB1	ITGB1	10051	0.015	0.36	NO
20	CDC42	CDC42	CDC42	10069	0.015	0.37	NO
21	MAPK3	MAPK3	MAPK3	10431	0.0097	0.35	NO
22	MAPK8	MAPK8	MAPK8	10593	0.0079	0.34	NO
23	DVL1	DVL1	DVL1	10959	0.0038	0.32	NO
24	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.29	NO
25	PAK1	PAK1	PAK1	11875	-0.0072	0.27	NO
26	DAG1	DAG1	DAG1	12019	-0.0091	0.27	NO
27	CTTN	CTTN	CTTN	12071	-0.0097	0.27	NO
28	RAPSN	RAPSN	RAPSN	12258	-0.012	0.26	NO
29	RAC1	RAC1	RAC1	12463	-0.015	0.25	NO
30	ACTA1	ACTA1	ACTA1	12996	-0.021	0.22	NO
31	PAK2	PAK2	PAK2	13210	-0.024	0.22	NO
32	PAK4	PAK4	PAK4	13812	-0.033	0.19	NO
33	SRC	SRC	SRC	15459	-0.06	0.11	NO
34	PTK2	PTK2	PTK2	16069	-0.075	0.09	NO
35	CHRNA1	CHRNA1	CHRNA1	17625	-0.17	0.036	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ZBTB16	ZBTB16	ZBTB16	135	0.7	0.1	YES
2	RUNX1T1	RUNX1T1	RUNX1T1	319	0.58	0.19	YES
3	KIT	KIT	KIT	429	0.53	0.27	YES
4	FLT3	FLT3	FLT3	1188	0.36	0.28	YES
5	TCF7	TCF7	TCF7	1215	0.35	0.34	YES
6	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.33	YES
7	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.37	YES
8	AKT3	AKT3	AKT3	2691	0.22	0.38	YES
9	STAT5A	STAT5A	STAT5A	3265	0.19	0.38	YES
10	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.4	YES
11	TCF7L2	TCF7L2	TCF7L2	3560	0.17	0.42	YES
12	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.45	YES
13	TCF7L1	TCF7L1	TCF7L1	3785	0.16	0.46	YES
14	LEF1	LEF1	LEF1	4152	0.15	0.47	YES
15	RUNX1	RUNX1	RUNX1	4468	0.14	0.47	YES
16	STAT5B	STAT5B	STAT5B	4598	0.13	0.48	YES
17	CCNA1	CCNA1	CCNA1	4876	0.12	0.49	YES
18	MYC	MYC	MYC	5154	0.11	0.49	YES
19	PIM1	PIM1	PIM1	5208	0.11	0.51	YES
20	CEBPA	CEBPA	CEBPA	5605	0.096	0.5	NO
21	SPI1	SPI1	SPI1	5999	0.085	0.49	NO
22	IKBKB	IKBKB	IKBKB	7005	0.061	0.45	NO
23	NFKB1	NFKB1	NFKB1	7019	0.061	0.46	NO
24	RARA	RARA	RARA	7589	0.051	0.43	NO
25	SOS2	SOS2	SOS2	7768	0.048	0.43	NO
26	PML	PML	PML	8422	0.037	0.4	NO
27	STAT3	STAT3	STAT3	8626	0.034	0.4	NO
28	PIM2	PIM2	PIM2	9036	0.028	0.38	NO
29	BAD	BAD	BAD	9341	0.024	0.36	NO
30	ARAF	ARAF	ARAF	9948	0.016	0.34	NO
31	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.32	NO
32	IKBKG	IKBKG	IKBKG	10276	0.012	0.32	NO
33	AKT2	AKT2	AKT2	10283	0.012	0.32	NO
34	RELA	RELA	RELA	10411	0.0099	0.32	NO
35	MAPK3	MAPK3	MAPK3	10431	0.0097	0.32	NO
36	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.31	NO
37	SOS1	SOS1	SOS1	10755	0.006	0.3	NO
38	CCND1	CCND1	CCND1	10823	0.0052	0.3	NO
39	MTOR	MTOR	MTOR	11444	-0.0022	0.26	NO
40	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.26	NO
41	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.25	NO
42	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.21	NO
43	RAF1	RAF1	RAF1	12740	-0.018	0.2	NO
44	AKT1	AKT1	AKT1	12834	-0.019	0.2	NO
45	NRAS	NRAS	NRAS	13027	-0.022	0.19	NO
46	CHUK	CHUK	CHUK	13268	-0.025	0.18	NO
47	GRB2	GRB2	GRB2	13272	-0.025	0.19	NO
48	RPS6KB1	RPS6KB1	RPS6KB1	13662	-0.031	0.17	NO
49	JUP	JUP	JUP	13707	-0.031	0.17	NO
50	KRAS	KRAS	KRAS	13800	-0.032	0.17	NO
51	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.16	NO
52	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.13	NO
53	BRAF	BRAF	BRAF	15055	-0.053	0.13	NO
54	HRAS	HRAS	HRAS	15640	-0.064	0.11	NO
55	RPS6KB2	RPS6KB2	RPS6KB2	15873	-0.07	0.1	NO
56	EIF4EBP1	EIF4EBP1	EIF4EBP1	17580	-0.17	0.038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADIPOQ	ADIPOQ	ADIPOQ	155	0.68	0.064	YES
2	LEP	LEP	LEP	246	0.62	0.12	YES
3	PCK1	PCK1	PCK1	253	0.62	0.19	YES
4	SLC2A4	SLC2A4	SLC2A4	308	0.59	0.25	YES
5	LEPR	LEPR	LEPR	363	0.55	0.31	YES
6	CD36	CD36	CD36	401	0.54	0.36	YES
7	ACACB	ACACB	ACACB	822	0.42	0.38	YES
8	PRKCQ	PRKCQ	PRKCQ	922	0.4	0.42	YES
9	PPARGC1A	PPARGC1A	PPARGC1A	1539	0.31	0.42	YES
10	G6PC2	G6PC2	G6PC2	2346	0.24	0.4	YES
11	SOCS3	SOCS3	SOCS3	2463	0.23	0.42	YES
12	ACSL5	ACSL5	ACSL5	2473	0.23	0.44	YES
13	TNFRSF1B	TNFRSF1B	TNFRSF1B	2535	0.23	0.47	YES
14	CPT1C	CPT1C	CPT1C	2679	0.22	0.48	YES
15	AKT3	AKT3	AKT3	2691	0.22	0.5	YES
16	IRS1	IRS1	IRS1	2837	0.21	0.52	YES
17	IRS2	IRS2	IRS2	2847	0.21	0.54	YES
18	MAPK10	MAPK10	MAPK10	2930	0.21	0.56	YES
19	RXRG	RXRG	RXRG	3381	0.18	0.55	YES
20	POMC	POMC	POMC	3843	0.16	0.55	YES
21	ACSL4	ACSL4	ACSL4	3849	0.16	0.56	YES
22	PRKAA2	PRKAA2	PRKAA2	3897	0.16	0.58	YES
23	JAK2	JAK2	JAK2	4589	0.13	0.55	NO
24	IRS4	IRS4	IRS4	5309	0.1	0.52	NO
25	PRKAA1	PRKAA1	PRKAA1	5342	0.1	0.53	NO
26	PPARA	PPARA	PPARA	5370	0.1	0.54	NO
27	ACSL1	ACSL1	ACSL1	5934	0.087	0.52	NO
28	RXRA	RXRA	RXRA	5993	0.085	0.53	NO
29	CAMKK1	CAMKK1	CAMKK1	6361	0.076	0.52	NO
30	NFKBIA	NFKBIA	NFKBIA	6624	0.07	0.51	NO
31	CPT1B	CPT1B	CPT1B	6940	0.062	0.5	NO
32	IKBKB	IKBKB	IKBKB	7005	0.061	0.5	NO
33	NFKB1	NFKB1	NFKB1	7019	0.061	0.51	NO
34	TRADD	TRADD	TRADD	7021	0.061	0.51	NO
35	STK11	STK11	STK11	7305	0.055	0.5	NO
36	TNFRSF1A	TNFRSF1A	TNFRSF1A	7333	0.055	0.51	NO
37	PRKAB1	PRKAB1	PRKAB1	7951	0.045	0.48	NO
38	CPT1A	CPT1A	CPT1A	8459	0.037	0.46	NO
39	STAT3	STAT3	STAT3	8626	0.034	0.45	NO
40	PRKAG2	PRKAG2	PRKAG2	8840	0.031	0.44	NO
41	PRKAB2	PRKAB2	PRKAB2	9461	0.022	0.41	NO
42	CAMKK2	CAMKK2	CAMKK2	10125	0.014	0.38	NO
43	IKBKG	IKBKG	IKBKG	10276	0.012	0.37	NO
44	AKT2	AKT2	AKT2	10283	0.012	0.37	NO
45	RELA	RELA	RELA	10411	0.0099	0.36	NO
46	MAPK8	MAPK8	MAPK8	10593	0.0079	0.35	NO
47	RXRB	RXRB	RXRB	11275	0.000074	0.32	NO
48	MTOR	MTOR	MTOR	11444	-0.0022	0.31	NO
49	ACSL3	ACSL3	ACSL3	12181	-0.011	0.27	NO
50	NFKBIB	NFKBIB	NFKBIB	12468	-0.015	0.25	NO
51	AKT1	AKT1	AKT1	12834	-0.019	0.24	NO
52	CHUK	CHUK	CHUK	13268	-0.025	0.22	NO
53	NFKBIE	NFKBIE	NFKBIE	13288	-0.025	0.22	NO
54	MAPK9	MAPK9	MAPK9	13385	-0.027	0.21	NO
55	ACSL6	ACSL6	ACSL6	13717	-0.031	0.2	NO
56	TRAF2	TRAF2	TRAF2	13722	-0.031	0.2	NO
57	PRKAG1	PRKAG1	PRKAG1	13724	-0.031	0.21	NO
58	PTPN11	PTPN11	PTPN11	14006	-0.036	0.19	NO
59	ADIPOR2	ADIPOR2	ADIPOR2	14687	-0.046	0.16	NO
60	PCK2	PCK2	PCK2	14698	-0.047	0.17	NO
61	AGRP	AGRP	AGRP	14924	-0.051	0.16	NO
62	ADIPOR1	ADIPOR1	ADIPOR1	15282	-0.057	0.15	NO
63	TNF	TNF	TNF	15505	-0.061	0.14	NO
64	SLC2A1	SLC2A1	SLC2A1	16926	-0.11	0.074	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADIPOQ	ADIPOQ	ADIPOQ	155	0.68	0.085	YES
2	CACNA1G	CACNA1G	CACNA1G	230	0.63	0.17	YES
3	SLC2A4	SLC2A4	SLC2A4	308	0.59	0.24	YES
4	SOCS2	SOCS2	SOCS2	476	0.51	0.3	YES
5	GCK	GCK	GCK	1172	0.36	0.32	YES
6	CACNA1C	CACNA1C	CACNA1C	1612	0.3	0.33	YES
7	CACNA1D	CACNA1D	CACNA1D	2043	0.27	0.35	YES
8	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.38	YES
9	PIK3CD	PIK3CD	PIK3CD	2151	0.26	0.41	YES
10	ABCC8	ABCC8	ABCC8	2210	0.25	0.44	YES
11	SOCS3	SOCS3	SOCS3	2463	0.23	0.46	YES
12	IRS1	IRS1	IRS1	2837	0.21	0.47	YES
13	IRS2	IRS2	IRS2	2847	0.21	0.5	YES
14	MAPK10	MAPK10	MAPK10	2930	0.21	0.52	YES
15	CACNA1A	CACNA1A	CACNA1A	3088	0.2	0.54	YES
16	KCNJ11	KCNJ11	KCNJ11	3138	0.2	0.56	YES
17	CACNA1E	CACNA1E	CACNA1E	3254	0.19	0.58	YES
18	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.6	YES
19	PIK3R5	PIK3R5	PIK3R5	3596	0.17	0.62	YES
20	SOCS1	SOCS1	SOCS1	3951	0.16	0.62	YES
21	PRKCE	PRKCE	PRKCE	4624	0.13	0.6	NO
22	IRS4	IRS4	IRS4	5309	0.1	0.57	NO
23	IKBKB	IKBKB	IKBKB	7005	0.061	0.49	NO
24	INSR	INSR	INSR	8442	0.037	0.42	NO
25	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.32	NO
26	MAPK3	MAPK3	MAPK3	10431	0.0097	0.31	NO
27	MAPK8	MAPK8	MAPK8	10593	0.0079	0.3	NO
28	MTOR	MTOR	MTOR	11444	-0.0022	0.26	NO
29	PKLR	PKLR	PKLR	11503	-0.0027	0.25	NO
30	HK1	HK1	HK1	11548	-0.0034	0.25	NO
31	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.25	NO
32	PIK3R3	PIK3R3	PIK3R3	11719	-0.0054	0.24	NO
33	PIK3R2	PIK3R2	PIK3R2	12537	-0.016	0.2	NO
34	SOCS4	SOCS4	SOCS4	12574	-0.016	0.2	NO
35	MAPK9	MAPK9	MAPK9	13385	-0.027	0.16	NO
36	PRKCD	PRKCD	PRKCD	14386	-0.042	0.11	NO
37	PKM2	PKM2	PKM2	14587	-0.044	0.11	NO
38	PIK3CB	PIK3CB	PIK3CB	14850	-0.05	0.099	NO
39	TNF	TNF	TNF	15505	-0.061	0.071	NO
40	HK2	HK2	HK2	15729	-0.067	0.068	NO
41	HK3	HK3	HK3	17440	-0.15	-0.0051	NO
42	CACNA1B	CACNA1B	CACNA1B	17600	-0.17	0.0094	NO
43	MAFA	MAFA	MAFA	17772	-0.2	0.028	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SLC2A4	SLC2A4	SLC2A4	308	0.59	0.16	YES
2	PRKCB	PRKCB	PRKCB	830	0.41	0.25	YES
3	GHR	GHR	GHR	1516	0.32	0.3	YES
4	PRKCA	PRKCA	PRKCA	1732	0.29	0.38	YES
5	PIK3CG	PIK3CG	PIK3CG	2125	0.26	0.43	YES
6	GH1	GH1	GH1	2754	0.22	0.46	YES
7	IRS1	IRS1	IRS1	2837	0.21	0.52	YES
8	STAT5A	STAT5A	STAT5A	3265	0.19	0.55	YES
9	PIK3R1	PIK3R1	PIK3R1	3343	0.18	0.6	YES
10	SOCS1	SOCS1	SOCS1	3951	0.16	0.61	YES
11	JAK2	JAK2	JAK2	4589	0.13	0.61	YES
12	STAT5B	STAT5B	STAT5B	4598	0.13	0.65	YES
13	SRF	SRF	SRF	6189	0.08	0.59	NO
14	INSR	INSR	INSR	8442	0.037	0.48	NO
15	SHC1	SHC1	SHC1	9164	0.026	0.44	NO
16	PLCG1	PLCG1	PLCG1	9466	0.022	0.43	NO
17	RPS6KA1	RPS6KA1	RPS6KA1	9804	0.018	0.42	NO
18	PTPN6	PTPN6	PTPN6	9901	0.017	0.42	NO
19	PIK3CA	PIK3CA	PIK3CA	10229	0.012	0.4	NO
20	MAPK3	MAPK3	MAPK3	10431	0.0097	0.4	NO
21	SOS1	SOS1	SOS1	10755	0.006	0.38	NO
22	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.34	NO
23	RAF1	RAF1	RAF1	12740	-0.018	0.28	NO
24	HNF1A	HNF1A	HNF1A	12776	-0.019	0.28	NO
25	GRB2	GRB2	GRB2	13272	-0.025	0.26	NO
26	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.22	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYH11	MYH11	MYH11	165	0.67	0.029	YES
2	CALML3	CALML3	CALML3	171	0.67	0.067	YES
3	ADCY5	ADCY5	ADCY5	328	0.57	0.091	YES
4	NPR1	NPR1	NPR1	407	0.54	0.12	YES
5	KCNMB1	KCNMB1	KCNMB1	496	0.5	0.14	YES
6	ADCY4	ADCY4	ADCY4	506	0.5	0.17	YES
7	PPP1R14A	PPP1R14A	PPP1R14A	520	0.49	0.2	YES
8	ADRA1A	ADRA1A	ADRA1A	604	0.46	0.22	YES
9	PRKCB	PRKCB	PRKCB	830	0.41	0.23	YES
10	PRKCQ	PRKCQ	PRKCQ	922	0.4	0.25	YES
11	PLA2G2A	PLA2G2A	PLA2G2A	937	0.39	0.27	YES
12	ACTG2	ACTG2	ACTG2	1276	0.35	0.27	YES
13	AVPR1A	AVPR1A	AVPR1A	1441	0.32	0.28	YES
14	CACNA1C	CACNA1C	CACNA1C	1612	0.3	0.29	YES
15	NPR2	NPR2	NPR2	1636	0.3	0.3	YES
16	PRKCA	PRKCA	PRKCA	1732	0.29	0.31	YES
17	KCNMB2	KCNMB2	KCNMB2	1792	0.29	0.33	YES
18	RAMP3	RAMP3	RAMP3	1846	0.28	0.34	YES
19	PLA2G4A	PLA2G4A	PLA2G4A	1854	0.28	0.36	YES
20	ADRA1D	ADRA1D	ADRA1D	1964	0.27	0.36	YES
21	CACNA1D	CACNA1D	CACNA1D	2043	0.27	0.38	YES
22	MYLK	MYLK	MYLK	2138	0.26	0.38	YES
23	PLA2G2D	PLA2G2D	PLA2G2D	2169	0.26	0.4	YES
24	CACNA1F	CACNA1F	CACNA1F	2189	0.26	0.41	YES
25	CALCRL	CALCRL	CALCRL	2294	0.25	0.42	YES
26	RAMP2	RAMP2	RAMP2	2305	0.25	0.43	YES
27	KCNMB4	KCNMB4	KCNMB4	2352	0.24	0.44	YES
28	MRVI1	MRVI1	MRVI1	2387	0.24	0.46	YES
29	ADCY2	ADCY2	ADCY2	2439	0.24	0.47	YES
30	AGTR1	AGTR1	AGTR1	2455	0.24	0.48	YES
31	PLCB1	PLCB1	PLCB1	2525	0.23	0.49	YES
32	CYP4A11	CYP4A11	CYP4A11	2575	0.23	0.5	YES
33	PPP1R12B	PPP1R12B	PPP1R12B	2578	0.23	0.51	YES
34	PTGIR	PTGIR	PTGIR	2644	0.22	0.52	YES
35	CYP4A22	CYP4A22	CYP4A22	2649	0.22	0.53	YES
36	ITPR1	ITPR1	ITPR1	2855	0.21	0.53	YES
37	PRKG1	PRKG1	PRKG1	2917	0.21	0.54	YES
38	KCNMA1	KCNMA1	KCNMA1	3124	0.2	0.54	YES
39	PLA2G5	PLA2G5	PLA2G5	3151	0.19	0.55	YES
40	ACTA2	ACTA2	ACTA2	3432	0.18	0.55	YES
41	PLCB2	PLCB2	PLCB2	3629	0.17	0.55	YES
42	GUCY1A3	GUCY1A3	GUCY1A3	3639	0.17	0.56	YES
43	EDNRA	EDNRA	EDNRA	3756	0.16	0.56	YES
44	GUCY1A2	GUCY1A2	GUCY1A2	3771	0.16	0.57	YES
45	JMJD7-PLA2G4B	JMJD7-PLA2G4B	JMJD7-PLA2G4B	3798	0.16	0.57	YES
46	ADCY1	ADCY1	ADCY1	3814	0.16	0.58	YES
47	ADORA2A	ADORA2A	ADORA2A	4004	0.16	0.58	YES
48	PLA2G10	PLA2G10	PLA2G10	4073	0.15	0.59	YES
49	PRKCH	PRKCH	PRKCH	4084	0.15	0.59	YES
50	MYL9	MYL9	MYL9	4391	0.14	0.58	NO
51	PRKCE	PRKCE	PRKCE	4624	0.13	0.58	NO
52	PLA2G3	PLA2G3	PLA2G3	4628	0.13	0.59	NO
53	PLA2G1B	PLA2G1B	PLA2G1B	5250	0.11	0.56	NO
54	CALD1	CALD1	CALD1	5432	0.1	0.56	NO
55	CALML6	CALML6	CALML6	5460	0.1	0.56	NO
56	GUCY1B3	GUCY1B3	GUCY1B3	5578	0.096	0.56	NO
57	ITPR2	ITPR2	ITPR2	5680	0.094	0.56	NO
58	PRKACB	PRKACB	PRKACB	5859	0.089	0.55	NO
59	ADCY9	ADCY9	ADCY9	6158	0.081	0.54	NO
60	GNA11	GNA11	GNA11	6257	0.078	0.54	NO
61	ARHGEF1	ARHGEF1	ARHGEF1	6330	0.076	0.54	NO
62	PLA2G6	PLA2G6	PLA2G6	6390	0.075	0.54	NO
63	ADRA1B	ADRA1B	ADRA1B	6584	0.07	0.54	NO
64	GNAQ	GNAQ	GNAQ	6634	0.069	0.54	NO
65	PLCB4	PLCB4	PLCB4	6773	0.066	0.53	NO
66	ADORA2B	ADORA2B	ADORA2B	6807	0.066	0.53	NO
67	ADCY6	ADCY6	ADCY6	7380	0.054	0.51	NO
68	KCNMB3	KCNMB3	KCNMB3	7505	0.052	0.5	NO
69	ARHGEF12	ARHGEF12	ARHGEF12	8092	0.042	0.47	NO
70	PPP1R12A	PPP1R12A	PPP1R12A	8726	0.033	0.44	NO
71	ROCK1	ROCK1	ROCK1	9419	0.023	0.4	NO
72	PRKX	PRKX	PRKX	9800	0.018	0.38	NO
73	GNA12	GNA12	GNA12	9809	0.018	0.38	NO
74	ROCK2	ROCK2	ROCK2	9880	0.017	0.38	NO
75	ARAF	ARAF	ARAF	9948	0.016	0.38	NO
76	ADCY7	ADCY7	ADCY7	9977	0.016	0.38	NO
77	MAPK3	MAPK3	MAPK3	10431	0.0097	0.35	NO
78	MAP2K2	MAP2K2	MAP2K2	10616	0.0077	0.34	NO
79	PLA2G12A	PLA2G12A	PLA2G12A	10879	0.0047	0.33	NO
80	RAMP1	RAMP1	RAMP1	10895	0.0045	0.33	NO
81	RHOA	RHOA	RHOA	10938	0.004	0.33	NO
82	MYL6	MYL6	MYL6	11067	0.0024	0.32	NO
83	MAPK1	MAPK1	MAPK1	11586	-0.0038	0.29	NO
84	CALM3	CALM3	CALM3	11748	-0.0059	0.28	NO
85	PRKACA	PRKACA	PRKACA	11771	-0.0062	0.28	NO
86	MYL6B	MYL6B	MYL6B	12371	-0.014	0.25	NO
87	ADCY8	ADCY8	ADCY8	12605	-0.016	0.24	NO
88	RAF1	RAF1	RAF1	12740	-0.018	0.23	NO
89	GNA13	GNA13	GNA13	12955	-0.021	0.22	NO
90	PLCB3	PLCB3	PLCB3	12962	-0.021	0.22	NO
91	PPP1CB	PPP1CB	PPP1CB	12964	-0.021	0.22	NO
92	ARHGEF11	ARHGEF11	ARHGEF11	12968	-0.021	0.22	NO
93	PPP1CC	PPP1CC	PPP1CC	13257	-0.025	0.21	NO
94	CALML5	CALML5	CALML5	13621	-0.03	0.19	NO
95	CALM1	CALM1	CALM1	13625	-0.03	0.19	NO
96	MAP2K1	MAP2K1	MAP2K1	14227	-0.039	0.16	NO
97	PRKCD	PRKCD	PRKCD	14386	-0.042	0.16	NO
98	CALM2	CALM2	CALM2	14511	-0.043	0.15	NO
99	BRAF	BRAF	BRAF	15055	-0.053	0.12	NO
100	CACNA1S	CACNA1S	CACNA1S	15185	-0.056	0.12	NO
101	ITPR3	ITPR3	ITPR3	15366	-0.059	0.11	NO
102	PPP1CA	PPP1CA	PPP1CA	15406	-0.059	0.12	NO
103	GNAS	GNAS	GNAS	15679	-0.065	0.1	NO
104	PRKCG	PRKCG	PRKCG	16685	-0.098	0.054	NO
105	MYLK3	MYLK3	MYLK3	17217	-0.13	0.032	NO
106	PLA2G2F	PLA2G2F	PLA2G2F	17237	-0.13	0.038	NO
107	MYLK2	MYLK2	MYLK2	18133	-0.33	0.0079	NO