rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(11) 513817 11 11 11 1 9 0 1 1 0 0 0.107 0.152 1.000 2 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(9), LIPT1(13) 1090040 22 19 17 1 0 3 2 6 11 0 0.132 0.217 1.000 3 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(3) 1063963 9 9 9 1 0 1 1 7 0 0 0.306 0.788 1.000 4 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(5), CD4(4), HLA-DRB1(7) 1196858 16 14 15 7 2 0 2 5 5 2 0.941 0.871 1.000 5 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPX1(5), PRKCE(6) 5195954 119 86 107 26 31 17 14 40 17 0 0.00673 0.898 1.000 6 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(12), ALDH1A2(17), BCMO1(5), RDH5(2) 2727712 36 33 35 8 10 8 5 9 4 0 0.117 0.956 1.000 7 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(5), HGD(6) 1586183 15 13 14 4 1 3 5 4 2 0 0.278 0.962 1.000 8 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 2 CD3D(5), CD3E(2) 572147 7 7 4 3 0 5 1 0 1 0 0.673 0.970 1.000 9 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 4 ALDH6A1(6), ALDOA(2), ALDOC(3), TPI1(3) 2014016 14 13 14 1 4 1 1 8 0 0 0.0914 0.970 1.000 10 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4) 4842817 81 59 74 12 27 13 11 20 10 0 0.00106 0.973 1.000 11 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4) 4842817 81 59 74 12 27 13 11 20 10 0 0.00106 0.973 1.000 12 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(4), CASP8(20), CFL1(2), CFLAR(3), PDE6D(2) 2623925 33 30 31 5 5 3 4 8 13 0 0.130 0.980 1.000 13 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), IL8(6), SLPI(2) 1095078 17 16 16 7 2 3 2 4 6 0 0.766 0.985 1.000 14 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(14), SPCS1(3), SPCS3(2) 2144483 24 21 22 6 9 3 2 7 3 0 0.201 0.997 1.000 15 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(7), B3GNT1(5), FUT1(11), FUT2(7), FUT9(10), GCNT2(26), ST8SIA1(10) 3829261 76 59 70 20 24 8 9 23 11 1 0.0900 0.999 1.000 16 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(12), CYP2C9(11) 1451222 23 21 22 5 3 8 2 9 1 0 0.292 0.999 1.000 17 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(11), CD28(5), CD3D(5), CD3E(2), CD4(4) 2096860 27 25 23 8 4 5 5 8 5 0 0.447 1.000 1.000 18 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 11 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), SDS(3) 7739440 115 80 104 21 35 18 18 26 18 0 0.00107 1.000 1.000 19 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(3), FOSB(6), GRIA2(29), PPP1R1B(1) 2306760 39 34 38 13 15 6 4 11 3 0 0.311 1.000 1.000 20 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(14), AGT(12), AGTR1(14), AGTR2(17), BDKRB2(6), KNG1(9), NOS3(23), REN(10) 6037396 105 68 90 20 30 9 11 29 26 0 0.0125 1.000 1.000 21 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(4), GALT(3), TGDS(1), UGDH(9), UGP2(12), UXS1(9) 3429686 38 33 39 7 8 2 6 11 11 0 0.281 1.000 1.000 22 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 8 ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), MIOX(3), UGDH(9) 5027341 72 53 64 14 20 11 10 15 16 0 0.0476 1.000 1.000 23 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 5 BAAT(3), CDO1(3), CSAD(6), GAD1(17), GAD2(15) 3319509 44 39 36 11 18 6 6 11 3 0 0.140 1.000 1.000 24 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(4), GALT(3), TGDS(1), UGDH(9), UXS1(9) 2672136 26 25 27 6 6 2 4 6 8 0 0.490 1.000 1.000 25 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(8), ERBB3(32), NRG1(33), UBE2D1(1) 5419920 74 60 62 15 22 18 9 13 12 0 0.0538 1.000 1.000 26 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 8 BIRC3(18), CASP8(20), FADD(1), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 4678118 61 49 51 16 12 15 5 11 18 0 0.160 1.000 1.000 27 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(7), ACAT2(9), ACYP1(2), ECHS1(4), EHHADH(15), GCDH(8), HADHA(12), SDHB(3), SDS(3) 5405606 63 50 57 14 15 10 11 14 13 0 0.0664 1.000 1.000 28 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(9), SUCLA2(9) 1413285 18 17 18 7 8 2 3 3 2 0 0.594 1.000 1.000 29 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(4), RANBP1(6), RANBP2(32), RANGAP1(4) 5440776 46 35 43 8 8 7 6 17 8 0 0.0692 1.000 1.000 30 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(6), GLUD1(4), GLUD2(22) 3043522 34 32 34 9 12 6 2 12 2 0 0.368 1.000 1.000 31 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(14), RAB11A(4), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(4), RAB6A(4), RAB9A(3) 2927576 42 33 40 12 13 6 9 6 8 0 0.224 1.000 1.000 32 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(9) 1207021 14 12 14 6 4 1 3 5 1 0 0.726 1.000 1.000 33 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(9), PAPSS1(5), PAPSS2(7), SULT1A2(4), SULT1E1(6), SULT2A1(6), SUOX(5) 4786107 42 28 38 7 11 5 4 15 7 0 0.103 1.000 1.000 34 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(6), CBS(4), CTH(6), MUT(8) 3247633 27 22 27 6 10 1 7 4 5 0 0.160 1.000 1.000 35 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(6), ST6GALNAC4(4), ST8SIA1(10) 3762847 34 31 32 9 11 7 4 6 6 0 0.205 1.000 1.000 36 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 3264996 27 24 24 7 11 4 1 8 3 0 0.324 1.000 1.000 37 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(2), CSF1(5), CSF3(3), EPO(1), IL11(6), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), IL9(2) 4283263 56 43 52 16 19 11 6 15 4 1 0.180 1.000 1.000 38 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 14 GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(11), MAPK14(8), NFATC2(12), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 6718345 99 76 94 29 41 21 6 17 14 0 0.0862 1.000 1.000 39 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNG(3), IFNGR1(8), IFNGR2(5), JAK1(22), STAT1(17) 4206167 55 42 49 15 16 12 0 15 10 2 0.407 1.000 1.000 40 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(15), PDXK(1), PDXP(1), PNPO(2), PSAT1(7) 3361327 26 22 25 7 6 7 3 6 4 0 0.341 1.000 1.000 41 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 4 ATP6V0C(1), GBA3(3), SHMT1(7), SHMT2(5) 1972343 16 16 19 8 6 1 2 3 4 0 0.876 1.000 1.000 42 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(7), MMP2(18), MMP9(19), RECK(14), TIMP1(2), TIMP2(3), TIMP3(11), TIMP4(4) 5166574 82 60 78 22 41 13 6 14 8 0 0.0665 1.000 1.000 43 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(2), CCR3(11), CD4(4), HLA-DRB1(7), IL1B(5), IL4(5), IL5RA(11), IL6(7) 3331389 52 33 46 17 17 7 5 16 5 2 0.488 1.000 1.000 44 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 BGN(8), DCN(9), FMOD(8), KERA(9) 1998166 34 30 33 11 9 6 1 15 3 0 0.648 1.000 1.000 45 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(13), DLL1(10), FURIN(17), PSEN1(4) 3217820 44 34 44 13 16 6 5 8 9 0 0.223 1.000 1.000 46 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(6), IDI1(4), SQLE(2) 2105761 16 16 17 5 1 2 4 5 4 0 0.601 1.000 1.000 47 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(7), ACAA2(4), ACAT1(7), ACAT2(9), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), SDS(3) 5892793 71 60 65 20 14 14 13 16 14 0 0.162 1.000 1.000 48 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(4), EHHADH(15), HADHA(12), SDS(3) 3381529 34 31 30 11 8 5 7 6 8 0 0.423 1.000 1.000 49 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(1), COQ5(2), COQ6(4), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1) 2825492 18 18 21 6 6 1 7 2 2 0 0.476 1.000 1.000 50 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(6), GGPS1(5), IDI1(4), IDI2(3), SQLE(2) 2887472 24 23 24 7 4 2 4 7 7 0 0.562 1.000 1.000 51 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 7 ADORA1(18), ADORA2A(7), ADORA2B(5), LTB4R(2), P2RY1(8), P2RY2(8), P2RY6(6) 2664314 54 39 50 18 24 10 8 9 3 0 0.113 1.000 1.000 52 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 7 ADAM17(13), AXIN1(10), BTRC(11), DLL1(10), FZD1(9), GSK3B(17), PSEN1(4) 5342044 74 53 71 22 22 14 11 13 13 1 0.128 1.000 1.000 53 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(27), CREM(10), FHL5(11), FSHB(6), FSHR(19), XPO1(9) 5181748 82 61 72 25 27 21 8 19 7 0 0.248 1.000 1.000 54 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 2 BMP1(17), BMPR1B(15) 2024102 32 27 31 10 11 5 2 7 7 0 0.647 1.000 1.000 55 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(7), ACOX1(11), ACOX3(10), ELOVL2(9), ELOVL5(3), ELOVL6(4), FADS2(12), HADHA(12), HSD17B12(3), SCD(4) 7469545 75 60 71 17 25 8 12 18 12 0 0.0305 1.000 1.000 56 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(5), CD4(4), CD80(6), HLA-DRB1(7), IL10(2), IL2(5), IL4(5) 2352651 34 23 32 11 8 4 5 10 5 2 0.588 1.000 1.000 57 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 10 ADCY1(27), ADRB2(3), PLCE1(34), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAP2B(3) 8506327 102 72 98 27 34 23 6 27 12 0 0.0485 1.000 1.000 58 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(12), ACO1(12), ACO2(7), ACSS1(7), ACSS2(10), FH(10), IDH2(17), MDH1(8), MDH2(3), SUCLA2(9) 8714026 95 76 86 24 23 19 12 27 14 0 0.0757 1.000 1.000 59 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(15), PARK2(14), SNCA(2), SNCAIP(8), UBE2E2(4), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5) 4435755 54 42 53 17 16 2 9 20 7 0 0.409 1.000 1.000 60 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(14), KARS(8) 3412261 27 24 25 8 4 4 6 8 5 0 0.534 1.000 1.000 61 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 C9orf47(2), CNR1(13), CNR2(1), DNMT1(28), MTNR1A(3), MTNR1B(15), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2) 6920622 88 64 80 23 41 10 7 18 12 0 0.0149 1.000 1.000 62 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(12), ACO2(7), FH(10), IDH2(17), MDH1(8), MDH2(3), SDHB(3), SUCLA2(9) 5673949 69 63 61 20 13 14 9 21 12 0 0.293 1.000 1.000 63 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(14), GBA(4), GBA3(3), LPO(10), MPO(17), PRDX6(5), TPO(36) 5518266 89 69 82 22 43 12 8 14 12 0 0.0534 1.000 1.000 64 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(6), CDK7(3), MNAT1(4), SHH(3), XPO1(9) 6040819 62 50 60 15 16 12 8 21 5 0 0.138 1.000 1.000 65 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 3 ACACA(36), ACACB(40), MCAT(3) 7490906 79 54 76 17 30 11 13 17 8 0 0.0254 1.000 1.000 66 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9) 3892945 46 41 42 17 5 15 6 16 4 0 0.524 1.000 1.000 67 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 CISH(2), IFNG(3), IFNGR1(8), JAK1(22), PTPRU(24), REG1A(8), STAT1(17) 6290372 84 60 76 22 35 15 4 15 13 2 0.181 1.000 1.000 68 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(27), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10) 6120079 64 49 58 14 21 18 6 9 10 0 0.0624 1.000 1.000 69 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(27), BAD(1), BAK1(2), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), CASP8AP2(30), CASP9(6), CES1(14) 6785459 97 68 87 28 21 10 18 21 26 1 0.536 1.000 1.000 70 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(3), CDK5R1(5), DPM2(1), EGR1(14), HRAS(4), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NGFR(5) 4106702 58 46 54 21 23 5 6 14 10 0 0.405 1.000 1.000 71 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(1), GPD2(11), NDUFA1(2), SDHA(14), SDHB(3), SDHD(4), UQCRC1(4) 4494132 46 35 46 12 18 4 8 13 3 0 0.233 1.000 1.000 72 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(11), ACOX3(10), FADS2(12), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10) 7146239 74 54 70 18 30 11 8 15 10 0 0.0458 1.000 1.000 73 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(14), GBA3(3), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TPO(36), TYR(12) 6336993 104 78 95 28 48 17 10 17 12 0 0.0653 1.000 1.000 74 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 11 AKT1(11), BAD(1), HRAS(4), IGF1R(22), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), SHC1(14), SOS1(16), YWHAH(5) 8694681 113 87 98 29 32 19 17 21 23 1 0.0891 1.000 1.000 75 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), KARS(8) 5021396 52 44 47 15 8 9 10 16 9 0 0.422 1.000 1.000 76 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), PGD(7) 11029534 147 91 135 31 34 24 23 49 17 0 0.00318 1.000 1.000 77 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(12), ALAS2(12), CPO(10), FECH(4), GATA1(19), HBB(3), HMBS(5), UROD(3), UROS(5) 5728569 74 52 68 18 23 17 7 17 10 0 0.113 1.000 1.000 78 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), RAC1(2), WASF1(6), WASL(18) 5691919 72 48 69 20 21 9 11 19 12 0 0.202 1.000 1.000 79 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(12), PON2(7), PON3(14), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 5765037 77 58 67 23 20 19 8 19 11 0 0.262 1.000 1.000 80 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(2), CTSD(6), ESR1(21), GREB1(29), HSPB2(3), MTA1(6), MTA3(4), PDZK1(2), TUBA8(5) 6286975 78 55 77 25 29 8 10 16 15 0 0.293 1.000 1.000 81 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(10), GNAQ(11), ITPKA(3), ITPKB(15) 3673735 44 37 41 15 15 9 3 11 6 0 0.476 1.000 1.000 82 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(19), EGF(8), HGS(10), RAB5A(4), TF(21), TFRC(7) 7052242 69 52 61 20 14 16 8 15 15 1 0.210 1.000 1.000 83 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(10), FOS(5), JUN(2), MAPK3(4), OPRK1(14), POLR2A(14), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 8802767 87 71 83 22 34 15 5 15 18 0 0.0858 1.000 1.000 84 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(8), ANKRD1(9), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(13), IL18(3), IL1A(1), IL1R1(7), MYOG(6), NR4A3(9), WDR1(7) 7302242 70 45 69 16 20 14 9 18 9 0 0.0669 1.000 1.000 85 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 8 CD3D(5), CD3E(2), CD4(4), FYN(17), HLA-DRB1(7), LCK(9), PTPRC(36), ZAP70(12) 5588107 92 72 79 28 21 19 14 16 20 2 0.250 1.000 1.000 86 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 177 ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), BAD(1), BCAR1(6), BCL2(2), BIRC2(7), BIRC3(18), CAPN2(10), CAV1(1), CAV2(4), CAV3(4), CCND1(2), CCND2(3), CCND3(2), CDC42(3), CHAD(10), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), CRKL(5), DIAPH1(7), DOCK1(24), EGF(8), ELK1(4), FARP2(13), FIGF(6), FLNA(31), FLNB(40), FLNC(39), FLT1(43), FN1(58), FYN(17), GRLF1(19), GSK3B(17), HGF(17), HRAS(4), IBSP(6), IGF1(6), IGF1R(22), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), JUN(2), KDR(42), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), MAP2K1(12), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PDPK1(4), PGF(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PRKCA(8), PRKCG(24), PTEN(333), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1A(2), RAP1B(2), RAPGEF1(19), RELN(95), ROCK1(35), ROCK2(20), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SPP1(4), SRC(3), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TLN1(23), TLN2(17), TNC(41), TNN(33), TNR(48), VASP(4), VAV1(24), VAV3(30), VCL(10), VEGFA(5), VEGFC(15), VTN(13), VWF(36), ZYX(5) 222687044 3229 422 2927 1307 910 691 409 744 455 20 0.961 1.000 1.000 87 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 157 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY7(13), ADCY8(34), ADCY9(22), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), ATP2A1(24), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), ATP2B4(26), AVPR1A(15), AVPR1B(5), BDKRB1(4), BDKRB2(6), BST1(3), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CCKAR(9), CCKBR(16), CD38(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM5(6), CHRNA7(1), CYSLTR1(9), DRD1(9), EDNRA(9), EDNRB(19), ERBB3(32), ERBB4(65), F2R(11), GNA11(8), GNA14(13), GNA15(6), GNAL(5), GNAQ(11), GRIN1(5), GRIN2A(55), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), GRPR(4), HRH1(4), HRH2(16), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MYLK(33), MYLK2(10), NOS1(31), NOS3(23), NTSR1(5), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), PDE1A(10), PDE1B(11), PDE1C(19), PDGFRA(64), PDGFRB(21), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PLN(1), PPID(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTAFR(1), PTGFR(8), PTK2B(13), RYR1(70), RYR2(138), RYR3(84), SLC25A4(4), SLC25A5(10), SLC8A1(24), SLC8A2(16), SLC8A3(17), SPHK1(3), SPHK2(5), TACR1(9), TACR2(4), TACR3(18), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(17), VDAC1(6), VDAC2(4), VDAC3(2) 164386910 2473 411 2373 915 885 428 272 537 340 11 0.351 1.000 1.000 88 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 213 ADCYAP1R1(5), ADORA1(18), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA2A(5), ADRA2B(7), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), C5AR1(8), CALCR(12), CALCRL(9), CCKAR(9), CCKBR(16), CGA(3), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CNR1(13), CNR2(1), CRHR1(6), CRHR2(6), CTSG(5), CYSLTR1(9), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2(10), F2R(11), F2RL2(8), FPR1(8), FSHB(6), FSHR(19), GABBR1(20), GABBR2(23), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GABRB1(11), GABRB2(10), GABRB3(19), GABRD(6), GABRE(12), GABRG1(21), GABRG2(20), GABRG3(12), GABRP(13), GABRQ(19), GABRR1(5), GABRR2(8), GALR1(5), GH1(5), GH2(6), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(11), GLP2R(10), GLRA1(10), GLRA2(9), GLRA3(13), GLRB(14), GNRHR(9), GPR156(17), GPR35(3), GPR50(9), GPR63(7), GPR83(7), GRIA1(38), GRIA2(29), GRIA3(15), GRIA4(46), GRID1(30), GRID2(28), GRIK1(13), GRIK2(49), GRIK3(33), GRIK4(21), GRIK5(15), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRIN3A(19), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM6(27), GRM7(36), GRM8(29), GRPR(4), GZMA(11), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HRH4(6), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LEP(1), LEPR(21), LHB(3), LTB4R(2), MAS1(3), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), MCHR1(8), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPBWR1(7), NPBWR2(1), NPFFR1(1), NPFFR2(14), NPY1R(6), NPY2R(12), NPY5R(7), NR3C1(11), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), P2RY1(8), P2RY10(15), P2RY14(11), P2RY2(8), P2RY4(8), P2RY6(6), PARD3(13), PPYR1(8), PRL(4), PRLHR(5), PRLR(10), PRSS1(7), PRSS3(6), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTH2R(16), RXFP1(7), RXFP2(21), SCTR(6), SSTR1(12), SSTR2(6), SSTR4(14), TAAR1(7), TAAR2(7), TAAR5(10), TAAR6(7), TAAR8(6), TAAR9(6), TACR1(9), TACR2(4), TACR3(18), THRA(6), THRB(14), TRHR(9), TRPV1(11), TSHB(2), VIPR1(7), VIPR2(11) 136389279 2374 410 2172 884 845 394 266 580 285 4 0.129 1.000 1.000 89 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 132 ACTB(4), ACTG1(6), CHAD(10), COL11A2(19), COL17A1(16), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), DES(6), DSC1(14), DSC2(17), DSC3(13), DSG1(23), DSG2(12), DSG3(17), DSG4(29), FN1(58), GJA1(9), GJA10(17), GJA3(5), GJA4(3), GJA5(7), GJA8(22), GJA9(6), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GJB7(4), GJC1(10), GJC3(4), GJD2(5), GJD4(4), IBSP(6), INA(9), ITGA6(16), ITGB4(18), KRT1(19), KRT10(7), KRT12(7), KRT13(11), KRT14(10), KRT15(9), KRT16(5), KRT17(11), KRT18(3), KRT19(4), KRT2(15), KRT20(3), KRT23(9), KRT24(5), KRT25(12), KRT27(3), KRT28(5), KRT3(13), KRT31(12), KRT32(7), KRT33A(8), KRT33B(6), KRT34(11), KRT35(7), KRT36(5), KRT37(11), KRT38(3), KRT39(9), KRT40(2), KRT5(8), KRT6A(8), KRT6B(6), KRT6C(7), KRT7(6), KRT71(9), KRT72(14), KRT73(14), KRT74(9), KRT75(14), KRT76(9), KRT77(6), KRT78(6), KRT79(8), KRT8(4), KRT81(3), KRT82(7), KRT83(4), KRT84(12), KRT85(15), KRT86(4), KRT9(13), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), LMNA(1), LMNB1(11), LMNB2(3), NES(30), PRPH(3), RELN(95), SPP1(4), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VIM(9), VTN(13), VWF(36) 156162691 2085 385 1958 843 748 308 282 470 276 1 0.892 1.000 1.000 90 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 228 AKT1(11), AKT2(8), AKT3(8), ARRB1(4), ARRB2(1), ATF2(7), ATF4(4), BDNF(5), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CACNA2D1(31), CACNA2D2(9), CACNA2D3(24), CACNA2D4(13), CACNB1(6), CACNB2(11), CACNB3(3), CACNB4(4), CACNG1(5), CACNG2(6), CACNG3(12), CACNG4(4), CACNG5(9), CACNG6(4), CACNG7(9), CACNG8(2), CASP3(4), CD14(6), CDC25B(11), CDC42(3), CHUK(27), CRKL(5), DAXX(18), DDIT3(5), DUSP1(7), DUSP10(6), DUSP16(11), DUSP3(4), DUSP4(6), DUSP5(2), DUSP6(7), DUSP7(8), DUSP9(9), ECSIT(7), EGF(8), ELK1(4), FAS(9), FASLG(3), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FLNA(31), FLNB(40), FLNC(39), FOS(5), GADD45G(1), GNA12(7), HRAS(4), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAPT(11), MAX(5), MEF2C(15), MKNK1(4), MKNK2(7), MOS(10), MRAS(4), MYC(5), NFATC2(12), NFATC4(12), NFKB1(11), NFKB2(6), NLK(12), NR4A1(3), NTF3(3), NTRK1(17), NTRK2(25), PAK1(11), PAK2(15), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PPM1A(9), PPM1B(6), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PPP5C(9), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTPN5(8), PTPN7(4), PTPRR(16), RAC1(2), RAC2(1), RAC3(2), RAP1A(2), RAP1B(2), RAPGEF2(35), RASA1(24), RASA2(17), RASGRF1(25), RASGRF2(26), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KA6(18), RRAS(2), RRAS2(7), SOS1(16), SOS2(17), SRF(4), STK3(8), STK4(9), STMN1(2), TAOK1(17), TAOK2(14), TAOK3(20), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(12) 171931370 2353 375 2201 785 749 449 273 511 363 8 0.00789 1.000 1.000 91 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 187 ABI2(5), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ARAF(10), ARHGEF1(15), ARHGEF12(12), ARHGEF4(9), ARHGEF6(19), ARHGEF7(23), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(4), BAIAP2(7), BCAR1(6), BDKRB1(4), BDKRB2(6), CD14(6), CDC42(3), CFL1(2), CFL2(2), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CRKL(5), CSK(5), CYFIP1(16), CYFIP2(10), DIAPH1(7), DIAPH2(28), DIAPH3(19), DOCK1(24), EGF(8), EZR(3), F2(10), F2R(11), FGD1(21), FGD3(16), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FN1(58), GIT1(4), GNA12(7), GNA13(3), GRLF1(19), GSN(4), HRAS(4), IQGAP1(31), IQGAP2(32), IQGAP3(24), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LIMK1(8), LIMK2(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MOS(10), MRAS(4), MSN(9), MYH10(17), MYH14(25), MYH9(43), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), NCKAP1(17), NCKAP1L(25), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PFN2(4), PFN4(6), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RDX(16), ROCK1(35), ROCK2(20), RRAS(2), RRAS2(7), SCIN(10), SLC9A1(12), SOS1(16), SOS2(17), SSH1(15), SSH2(16), SSH3(4), TIAM1(42), TIAM2(26), TMSL3(2), VAV1(24), VAV3(30), VCL(10), WAS(4), WASF1(6), WASF2(5), WASL(18) 170721394 2193 368 2044 789 635 403 267 528 348 12 0.526 1.000 1.000 92 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 82 CD36(3), CD44(6), CD47(8), CHAD(10), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), DAG1(10), FN1(58), FNDC1(44), FNDC3A(15), FNDC4(6), FNDC5(2), GP5(9), GP6(13), GP9(1), HMMR(17), HSPG2(27), IBSP(6), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), RELN(95), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SPP1(4), SV2A(24), SV2B(11), SV2C(13), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VTN(13), VWF(36) 140472741 1818 366 1718 753 619 271 237 429 258 4 0.945 1.000 1.000 93 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(21), ATP1B1(4), ATP1B2(4), ATP1B3(4), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1S(34), CACNB1(6), CACNB3(3), CALM2(1), CALM3(1), CALR(2), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CASQ1(5), CASQ2(11), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), GJA1(9), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), ITPR1(43), ITPR2(49), ITPR3(44), KCNB1(22), KCNJ3(11), KCNJ5(11), MIB1(13), MYCBP(1), NME7(9), PEA15(1), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLN(1), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SLC8A3(17), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1) 121877764 1725 364 1687 639 637 270 191 368 250 9 0.312 1.000 1.000 94 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 124 ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), AMOTL1(15), ASH1L(64), CASK(11), CDC42(3), CDK4(4), CGN(18), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTTN(5), EPB41(11), EPB41L1(14), EPB41L2(12), EPB41L3(35), EXOC3(3), EXOC4(22), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), HCLS1(16), HRAS(4), IGSF5(16), INADL(18), JAM2(2), JAM3(9), LLGL1(7), LLGL2(8), MAGI1(31), MAGI2(32), MAGI3(10), MLLT4(21), MPDZ(26), MPP5(7), MRAS(4), MYH1(47), MYH10(17), MYH11(49), MYH13(28), MYH14(25), MYH15(37), MYH2(42), MYH3(46), MYH4(30), MYH6(34), MYH7(28), MYH7B(31), MYH8(47), MYH9(43), MYL2(2), MYL7(1), MYL9(3), OCLN(2), PARD3(13), PARD6A(2), PARD6B(2), PARD6G(7), PPM1J(3), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP2R3A(16), PPP2R4(4), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PTEN(333), RAB13(1), RAB3B(3), RRAS(2), RRAS2(7), SPTAN1(30), SRC(3), SYMPK(11), TJAP1(5), TJP1(25), TJP2(17), TJP3(12), VAPA(2), YES1(10), ZAK(12) 127031966 1911 355 1660 667 561 450 229 391 262 18 0.229 1.000 1.000 95 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 134 ACTA1(14), ACTA2(3), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADM(5), ARRB1(4), ARRB2(1), ATF1(6), ATF2(7), ATF3(1), ATF4(4), ATF5(2), ATP2A2(17), ATP2A3(13), CACNB3(3), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CNN1(5), CNN2(4), CORIN(21), CREB3(6), CRHR1(6), DGKZ(9), ETS2(5), FOS(5), GABPA(14), GABPB2(4), GBA2(15), GJA1(9), GNAQ(11), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), GSTO1(2), GUCA2B(3), GUCY1A3(33), IGFBP1(2), IGFBP2(3), IGFBP3(8), IGFBP4(4), IGFBP6(2), IL1B(5), IL6(7), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), MIB1(13), MYL2(2), MYL4(4), MYLK2(10), NFKB1(11), NOS1(31), NOS3(23), OXTR(3), PDE4B(13), PDE4D(9), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLCD1(10), PLCG1(19), PLCG2(28), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RAMP1(2), RAMP2(2), RAMP3(7), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RLN1(4), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SP1(7), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1) 108292599 1512 351 1467 517 519 233 188 342 224 6 0.0410 1.000 1.000 96 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 120 ABL1(31), ABLIM1(11), ABLIM2(7), ABLIM3(17), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CFL2(2), CXCL12(2), CXCR4(7), DCC(42), DPYSL2(11), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(6), EFNB1(6), EFNB2(1), EFNB3(11), EPHA1(11), EPHA2(12), EPHA3(70), EPHA4(26), EPHA5(47), EPHA6(28), EPHA7(45), EPHA8(19), EPHB1(38), EPHB2(16), EPHB3(12), EPHB4(15), EPHB6(15), FES(7), FYN(17), GNAI1(5), GNAI2(2), GNAI3(2), GSK3B(17), HRAS(4), ITGB1(13), L1CAM(17), LIMK1(8), LIMK2(13), LRRC4C(17), MAPK1(3), MAPK3(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NGEF(19), NRP1(12), NTN1(5), NTN4(10), NTNG1(17), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLXNA1(22), PLXNA2(26), PLXNA3(24), PLXNB1(22), PLXNB2(28), PLXNB3(25), PLXNC1(20), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RAC3(2), RASA1(24), RGS3(25), RND1(3), ROBO1(32), ROBO3(12), ROCK1(35), ROCK2(20), SEMA3A(21), SEMA3B(7), SEMA3C(18), SEMA3D(29), SEMA3E(22), SEMA3F(13), SEMA3G(10), SEMA4A(13), SEMA4B(5), SEMA4C(5), SEMA4D(18), SEMA4F(14), SEMA4G(11), SEMA5A(21), SEMA5B(26), SEMA6A(9), SEMA6B(8), SEMA6C(13), SEMA6D(15), SEMA7A(3), SLIT1(31), SLIT2(33), SLIT3(25), SRGAP1(25), SRGAP2(9), SRGAP3(21), UNC5A(9), UNC5B(10), UNC5C(17), UNC5D(22) 118638503 1730 349 1605 630 581 303 186 383 269 8 0.523 1.000 1.000 97 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 35 ACTA1(14), ACTA2(3), ACTN2(19), ACTN3(6), ACTN4(8), DES(6), DMD(85), FAM48A(13), MYBPC1(12), MYBPC2(16), MYBPC3(15), MYH3(46), MYH6(34), MYH7(28), MYH8(47), MYL2(2), MYL3(1), MYL4(4), MYL9(3), NEB(106), TMOD1(8), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(3), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(8), TPM3(7), TPM4(9), TTN(882), VIM(9) 78815721 1415 348 1302 416 398 292 173 420 113 19 0.000176 1.000 1.000 98 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 228 ACVR1(9), ACVR2B(14), AMHR2(4), BMP2(9), BMP7(15), BMPR1B(15), CCL11(2), CCL13(1), CCL15(2), CCL16(2), CCL17(1), CCL18(2), CCL22(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL4(1), CCL7(2), CCL8(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CD27(4), CD40(7), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(5), CSF1R(16), CSF2RB(13), CSF3(3), CSF3R(19), CX3CL1(5), CX3CR1(6), CXCL1(1), CXCL10(2), CXCL11(4), CXCL12(2), CXCL14(2), CXCL16(3), CXCL5(6), CXCL6(1), CXCL9(7), CXCR3(5), CXCR4(7), CXCR6(1), EDA(5), EDA2R(4), EDAR(8), EGF(8), EPO(1), EPOR(2), FAS(9), FASLG(3), FLT1(43), FLT3(36), FLT3LG(1), FLT4(18), GDF5(13), GH1(5), GH2(6), GHR(12), HGF(17), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL15(1), IL15RA(1), IL17A(3), IL17B(1), IL17RA(8), IL17RB(8), IL18(3), IL18R1(16), IL18RAP(12), IL19(3), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL1RAP(7), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL25(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL8(6), IL9(2), INHBA(21), INHBB(3), INHBC(4), INHBE(3), KDR(42), KITLG(3), LEP(1), LEPR(21), LIF(1), LIFR(41), LTA(1), LTBR(5), MPL(9), NGFR(5), OSM(4), OSMR(22), PDGFB(2), PDGFC(10), PDGFRA(64), PDGFRB(21), PF4(3), PLEKHO2(7), PPBP(6), PRL(4), PRLR(10), RELT(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFRSF11A(6), TNFRSF11B(7), TNFRSF13B(7), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFRSF8(8), TNFRSF9(10), TNFSF10(3), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(4), TNFSF14(4), TNFSF15(3), TNFSF4(6), TNFSF8(6), TPO(36), TSLP(3), VEGFA(5), VEGFC(15), XCL1(1), XCL2(4), XCR1(6) 108443588 1477 337 1345 505 398 276 176 405 217 5 0.100 1.000 1.000 99 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 118 ALCAM(12), CADM1(18), CADM3(15), CD2(7), CD22(17), CD226(6), CD274(5), CD276(6), CD28(5), CD34(7), CD4(4), CD40(7), CD40LG(10), CD6(6), CD80(6), CD86(2), CD8A(2), CD8B(4), CDH15(3), CDH2(40), CDH3(9), CDH4(24), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CNTN1(31), CNTN2(13), CNTNAP1(15), CNTNAP2(39), CTLA4(5), ESAM(6), F11R(4), GLG1(15), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), ICAM1(4), ICAM2(6), ICAM3(3), ICOS(2), ICOSLG(5), ITGA4(20), ITGA6(16), ITGA8(20), ITGA9(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGB1(13), ITGB2(18), ITGB7(10), ITGB8(12), JAM2(2), JAM3(9), L1CAM(17), MAG(11), MPZ(2), MPZL1(7), NCAM1(18), NCAM2(29), NEGR1(4), NEO1(14), NFASC(41), NLGN1(21), NLGN2(5), NLGN3(11), NRCAM(21), NRXN1(46), NRXN2(24), NRXN3(35), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(36), PTPRF(23), PTPRM(48), PVR(2), PVRL1(9), PVRL2(5), PVRL3(5), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SELE(13), SELL(5), SELP(15), SIGLEC1(19), SPN(6), VCAM1(15), VCAN(74) 92717775 1317 332 1242 511 403 192 158 351 208 5 0.742 1.000 1.000 100 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 67 CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS2(10), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), FN3K(1), IMPA1(4), IMPA2(4), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5D(10), INPP5E(3), INPPL1(16), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), OCRL(21), PI4KA(29), PI4KB(5), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3C3(29), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PRKCA(8), PRKCG(24), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15) 76635767 1238 320 1061 443 308 350 146 262 162 10 0.497 1.000 1.000 101 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 100 ABL1(31), ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), ATM(237), ATR(53), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDC14A(14), CDC14B(6), CDC16(6), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(6), CDC26(1), CDC27(21), CDC6(10), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CHEK1(11), CREBBP(81), CUL1(17), DBF4(11), E2F2(7), E2F3(6), EP300(56), ESPL1(23), FZR1(4), GADD45G(1), GSK3B(17), HDAC1(5), HDAC2(8), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTTG1(2), RB1(139), RBL1(21), RBL2(24), RBX1(1), SFN(1), SKP1(2), SKP2(3), SMC1A(21), SMC1B(28), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 88095997 1339 319 1126 462 274 374 123 312 235 21 0.438 1.000 1.000 102 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 123 AXIN1(10), AXIN2(27), BTRC(11), CACYBP(4), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(6), CHD8(37), CREBBP(81), CSNK1A1(3), CSNK1A1L(9), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(14), CTNNBIP1(1), CUL1(17), CXXC4(2), DAAM1(10), DAAM2(20), DKK1(9), DKK4(8), DVL2(12), DVL3(10), EP300(56), FBXW11(13), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LEF1(9), LRP5(11), LRP6(34), MAP3K7(9), MAPK10(18), MAPK8(17), MAPK9(13), MMP7(10), MYC(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NKD1(6), NLK(12), PLCB1(23), PLCB3(15), PLCB4(23), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRICKLE1(24), PRICKLE2(18), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PSEN1(4), RAC1(2), RAC2(1), RAC3(2), RBX1(1), ROCK1(35), ROCK2(20), RUVBL1(9), SENP2(4), SFRP1(3), SFRP4(9), SFRP5(1), SIAH1(2), SKP1(2), TBL1X(9), TBL1XR1(11), TCF7(15), TCF7L1(8), VANGL2(9), WIF1(5), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 88915496 1212 315 1123 415 412 207 138 245 203 7 0.135 1.000 1.000 103 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 71 ABL1(31), ACTN1(13), ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGEF6(19), ARHGEF7(23), BCAR1(6), CAV1(1), CDC42(3), CDKN2A(9), CSE1L(10), DOCK1(24), EPHB2(16), FYN(17), GRB7(3), GRLF1(19), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGB3BP(3), MAP3K11(12), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MRAS(4), MYLK(33), MYLK2(10), P4HB(6), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CB(6), PKLR(12), PLCG1(19), PLCG2(28), PTEN(333), PTK2(24), RALA(8), RHO(5), ROCK1(35), ROCK2(20), SHC1(14), SOS1(16), SOS2(17), SRC(3), TERF2IP(4), TLN1(23), TLN2(17), VASP(4), WAS(4), ZYX(5) 76500668 1239 314 1060 477 241 336 159 279 209 15 0.882 1.000 1.000 104 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 143 ADORA1(18), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCBP2(14), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CCRL1(7), CCRL2(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CMKLR1(8), CNR1(13), CNR2(1), CX3CR1(6), CXCR3(5), CXCR4(7), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2R(11), F2RL2(8), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GPR17(3), GPR173(3), GPR3(3), GPR35(3), GPR37(15), GPR37L1(8), GPR4(7), GPR44(2), GPR50(9), GPR6(8), GPR63(7), GPR77(4), GPR83(7), GPR85(7), GPR87(12), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LTB4R(2), MAS1(3), MC1R(2), MC3R(14), MC4R(7), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPN1SW(8), OPN3(7), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OR10A5(3), OR12D3(4), OR1C1(11), OR1F1(4), OR1Q1(5), OR2H1(5), OR7A5(6), OR8B8(6), OXTR(3), P2RY1(8), P2RY10(15), P2RY12(6), P2RY14(11), P2RY2(8), P2RY6(6), PPYR1(8), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), RGR(4), RHO(5), RRH(7), SSTR1(12), SSTR2(6), SSTR4(14), SUCNR1(6), TRHR(9) 70048968 1130 313 1052 433 429 189 143 259 110 0 0.0414 1.000 1.000 105 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 83 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRB1(4), CSNK1D(15), DRD1(9), DRD2(9), EGF(8), GJA1(9), GJD2(5), GNA11(8), GNAI1(5), GNAI2(2), GNAI3(2), GNAQ(11), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), HTR2B(7), HTR2C(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAP2K5(6), MAP3K2(9), MAPK1(3), MAPK3(4), MAPK7(6), NPR1(18), NPR2(17), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PLCB1(23), PLCB3(15), PLCB4(23), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), PRKX(3), SOS1(16), SOS2(17), SRC(3), TJP1(25), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10) 80580429 1167 311 1100 426 388 202 155 278 140 4 0.259 1.000 1.000 106 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 138 AKT1(11), AKT2(8), AKT3(8), BCL2L1(1), CBLB(17), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(81), CSF2RB(13), CSF3(3), CSF3R(19), EP300(56), EPO(1), EPOR(2), GH1(5), GH2(6), GHR(12), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL13RA2(17), IL15(1), IL15RA(1), IL19(3), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL9(2), IRF9(6), JAK1(22), JAK3(31), LEP(1), LEPR(21), LIF(1), LIFR(41), MPL(9), MYC(5), OSM(4), OSMR(22), PIAS1(4), PIAS2(5), PIAS3(10), PIAS4(2), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIM1(4), PRL(4), PRLR(10), PTPN11(41), PTPN6(4), SOCS2(4), SOCS4(1), SOCS5(12), SOCS7(1), SOS1(16), SOS2(17), SPRED1(10), SPRED2(10), SPRY1(10), SPRY2(2), SPRY4(7), STAM(4), STAM2(4), STAT1(17), STAT2(12), STAT3(10), STAT4(13), STAT5A(10), STAT5B(20), STAT6(4), TPO(36), TSLP(3), TYK2(5) 90741122 1150 308 1020 398 292 227 146 309 173 3 0.339 1.000 1.000 107 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 75 ABL1(31), ATM(237), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDAN1(9), CDC14A(14), CDC14B(6), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(6), CDC6(10), CDK2(5), CDK4(4), CDKN1A(2), CDKN2A(9), CHEK1(11), DTX4(8), E2F2(7), E2F3(6), E2F4(2), E2F5(6), EP300(56), ESPL1(23), GSK3B(17), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), HDAC8(3), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MPEG1(8), MPL(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTPRA(6), PTTG1(2), RB1(139), RBL1(21), SKP2(3), TBC1D8(11), TFDP1(10), TGFB1(2) 70105021 1071 305 894 379 211 323 100 245 174 18 0.497 1.000 1.000 108 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 139 ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADK(7), ADSL(13), ADSS(8), ADSSL1(6), AK1(2), AK5(10), AK7(8), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), FHIT(1), GART(5), GDA(7), GMPR(9), GMPR2(3), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NPR1(18), NPR2(17), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE10A(19), PDE11A(16), PDE1A(10), PDE1C(19), PDE2A(10), PDE3B(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6D(2), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PPAT(8), PRIM1(5), PRIM2(3), PRPS1L1(4), PRPS2(6), PRUNE(4), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), XDH(19) 111306915 1254 305 1194 425 369 190 192 303 199 1 0.122 1.000 1.000 109 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(27), ATM(237), ATR(53), BAI1(13), BID(2), CASP3(4), CASP8(20), CASP9(6), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG1(5), CCNG2(4), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN2A(9), CHEK1(11), CYCS(1), DDB2(1), EI24(1), FAS(9), GADD45G(1), GTSE1(5), IGF1(6), IGFBP3(8), MDM2(11), MDM4(7), PPM1D(6), PTEN(333), RCHY1(4), RFWD2(6), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(7), SERPINE1(10), SESN1(5), SESN2(9), SESN3(8), SFN(1), SIAH1(2), STEAP3(6), THBS1(14), TNFRSF10B(8), TP53I3(2), TP73(5), TSC2(17), ZMAT3(12) 40579033 973 304 747 361 130 357 112 203 152 19 0.667 1.000 1.000 110 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 58 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2L1(1), CDC42(3), CDK2(5), CDKN1B(6), CDKN2A(9), CREB1(3), CREB3(6), CREB5(8), EBP(6), ERBB4(65), F2RL2(8), GAB1(15), GSK3A(6), GSK3B(17), IGF1(6), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), MYC(5), NOLC1(9), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARD3(13), PARD6A(2), PDK1(7), PIK3CD(11), PPP1R13B(10), PREX1(27), PTEN(333), PTK2(24), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SLC2A4(8), SOS1(16), SOS2(17), TSC1(18), TSC2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 46022008 970 295 783 366 174 298 135 204 150 9 0.769 1.000 1.000 111 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 62 ADCY1(27), ADCY8(34), ARAF(10), ATF4(4), CACNA1C(35), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CREBBP(81), EP300(56), GNAQ(11), GRIA1(38), GRIA2(29), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), PLCB1(23), PLCB3(15), PLCB4(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R1A(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAP1A(2), RAP1B(2), RAPGEF3(8), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18) 62927923 962 294 898 372 321 209 106 198 125 3 0.612 1.000 1.000 112 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 99 ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BCAR1(6), CDC42(3), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNND1(19), CXCL12(2), CXCR4(7), CYBB(6), ESAM(6), EZR(3), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), GRLF1(19), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), ITK(26), JAM2(2), JAM3(9), MAPK12(4), MAPK13(6), MAPK14(8), MLLT4(21), MMP2(18), MMP9(19), MSN(9), MYL2(2), MYL7(1), MYL9(3), NCF1(4), NCF2(10), NCF4(5), NOX1(4), NOX3(14), OCLN(2), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAC1(2), RAC2(1), RAP1A(2), RAP1B(2), RAPGEF3(8), RAPGEF4(12), RASSF5(6), RHOH(5), ROCK1(35), ROCK2(20), SIPA1(10), TXK(12), VASP(4), VAV1(24), VAV3(30), VCAM1(15), VCL(10) 74446439 990 293 921 367 316 170 102 240 157 5 0.738 1.000 1.000 113 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 117 ACACA(36), ACACB(40), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBLB(17), CBLC(3), CRKL(5), ELK1(4), EXOC7(4), FBP1(1), FBP2(5), FLOT1(7), FLOT2(2), FOXO1(8), G6PC(5), G6PC2(3), GCK(6), GSK3B(17), GYS1(6), GYS2(17), HRAS(4), IKBKB(9), INPP5D(10), INSR(21), IRS1(21), IRS4(36), LIPE(11), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MKNK1(4), MKNK2(7), PCK1(6), PCK2(6), PDE3A(21), PDE3B(10), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PKLR(12), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R3A(45), PPP1R3B(4), PPP1R3C(6), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACA(2), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCI(25), PRKCZ(4), PRKX(3), PTPN1(11), PTPRF(23), PYGB(15), PYGL(8), PYGM(12), RAPGEF1(19), RHEB(5), RHOQ(6), RPS6(3), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SLC2A4(8), SOCS2(4), SOCS4(1), SORBS1(15), SOS1(16), SOS2(17), SREBF1(8), TRIP10(5), TSC1(18), TSC2(17) 95576634 1113 292 1033 389 352 182 141 266 170 2 0.215 1.000 1.000 114 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 73 ABL1(31), ABL2(20), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CBLB(17), CBLC(3), CDKN1A(2), CDKN1B(6), CRKL(5), EGF(8), ELK1(4), ERBB3(32), ERBB4(65), EREG(3), GAB1(15), GSK3B(17), HBEGF(1), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYC(5), NCK1(1), NCK2(5), NRG1(33), NRG2(8), NRG3(18), NRG4(2), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SRC(3), STAT5A(10), STAT5B(20) 58299944 814 285 732 301 202 169 118 173 151 1 0.793 1.000 1.000 115 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 87 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), AKAP1(7), AKAP10(6), AKAP11(30), AKAP12(36), AKAP2(2), AKAP3(26), AKAP4(16), AKAP5(6), AKAP6(44), AKAP8(8), AKAP9(75), ARHGEF1(15), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(7), GNA13(3), GNA14(13), GNA15(6), GNAI2(2), GNAI3(2), GNAL(5), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), HRAS(4), IL18BP(4), ITPR1(43), KCNJ3(11), PALM2(1), PDE1A(10), PDE1B(11), PDE1C(19), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PLCB3(15), PPP3CA(5), PPP3CC(7), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKD3(19), RRAS(2), SLC9A1(12), USP5(10) 77410626 1001 282 934 362 306 177 118 225 172 3 0.322 1.000 1.000 116 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGAP1(3), ARHGAP4(7), ARHGEF11(24), BTK(12), CDC42(3), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(16), ITPR1(43), ITPR2(49), ITPR3(44), LIMK1(8), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDK1(7), PIK3CD(11), PIK3CG(41), PITX2(2), PPP1R13B(10), PTEN(333), RACGAP1(5), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), SAG(5), WASF1(6), WASL(18) 43799407 891 282 737 331 164 273 114 194 133 13 0.772 1.000 1.000 117 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 44 FN3K(1), IMPA1(4), IMPA2(4), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(16), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), MINPP1(6), MIOX(3), OCRL(21), PI4KA(29), PI4KB(5), PIK3C3(29), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15) 45248283 853 279 691 305 187 276 98 174 109 9 0.504 1.000 1.000 118 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 87 AKT1(11), AKT3(8), BCAR1(6), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(10), CAPN3(11), CAPN5(14), CAPN6(15), CAPN7(12), CAPN9(5), CAPNS1(4), CAV1(1), CAV2(4), CAV3(4), CDC42(3), CSK(5), DOCK1(24), FYN(17), GIT2(11), ILK(3), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK10(18), MAPK12(4), MAPK4(4), MAPK7(6), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(19), RHO(5), ROCK1(35), ROCK2(20), SDCCAG8(4), SEPP1(4), SHC1(14), SHC3(5), SORBS1(15), SOS1(16), SRC(3), TLN1(23), TNS1(39), VASP(4), VAV3(30), VCL(10), ZYX(5) 86986575 1001 277 949 379 291 145 108 263 185 9 0.896 1.000 1.000 119 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 68 ARAF(10), C7orf16(11), CACNA1A(28), CRHR1(6), GNA11(8), GNA12(7), GNA13(3), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GRIA1(38), GRIA2(29), GRIA3(15), GRID2(28), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), IGF1(6), IGF1R(22), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NOS1(31), NOS3(23), NPR1(18), NPR2(17), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB3(15), PLCB4(23), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), RYR1(70) 68687519 1000 276 947 376 351 158 122 230 136 3 0.616 1.000 1.000 120 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 72 ACVR1(9), ACVRL1(8), AKT1(11), AURKB(6), BUB1(16), CDKL1(6), CDKL2(16), CDS2(10), CLK1(10), CLK2(3), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), IMPA1(4), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MAP3K10(11), MOS(10), NEK1(20), NEK3(10), OCRL(21), PAK4(6), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CB(6), PIK3CG(41), PIM2(1), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28), PLK3(3), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKG1(18), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KB1(9), STK11(38), TGFBR1(20), VRK1(7) 66500774 914 276 827 314 280 185 108 201 138 2 0.383 1.000 1.000 121 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 58 ATM(237), CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CREB3(6), CREB3L1(6), CREB3L3(7), CREB3L4(5), E2F2(7), E2F3(6), E2F4(2), E2F5(6), GBA2(15), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MNAT1(4), MYC(5), MYT1(25), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLE(41), POLE2(6), PRIM1(5), RB1(139), RBL1(21), RPA1(12), RPA2(1), TFDP1(10), TFDP2(5) 45292935 774 273 641 270 135 232 78 189 124 16 0.350 1.000 1.000 122 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 87 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), CREB3(6), CREB3L1(6), CREB3L2(5), CREB3L3(7), CREB3L4(5), CREBBP(81), DCT(22), DVL2(12), DVL3(10), EDN1(3), EDNRB(19), EP300(56), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GSK3B(17), HRAS(4), KITLG(3), LEF1(9), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MC1R(2), MITF(19), PLCB1(23), PLCB3(15), PLCB4(23), POMC(4), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), TCF7(15), TCF7L1(8), TYR(12), TYRP1(6), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 61444974 908 273 846 358 339 162 112 178 117 0 0.425 1.000 1.000 123 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 84 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ATF4(4), CACNA1C(35), CACNA1D(29), CACNA1F(37), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDC42(3), CGA(3), ELK1(4), FSHB(6), GNA11(8), GNAQ(11), GNRH1(4), GNRHR(9), HBEGF(1), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), LHB(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK9(13), MMP14(7), MMP2(18), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB3(15), PLCB4(23), PLD1(19), PLD2(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCD(15), PRKX(3), PTK2B(13), SOS1(16), SOS2(17), SRC(3) 78223281 1010 272 966 341 331 170 125 232 149 3 0.0807 1.000 1.000 124 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(64), ASH2L(7), C17orf79(1), CARM1(3), CTCFL(19), DOT1L(10), EED(2), EHMT1(11), EHMT2(10), EZH1(9), EZH2(51), FBXO11(15), HCFC1(13), HSF4(5), JMJD4(2), JMJD6(9), KDM6A(27), MEN1(32), MLL(58), MLL2(67), MLL3(88), MLL4(41), MLL5(32), NSD1(29), OGT(10), PAXIP1(22), PPP1CA(2), PPP1CB(6), PPP1CC(2), PRDM2(36), PRDM7(6), PRDM9(43), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), RBBP5(4), SATB1(17), SETD1A(21), SETD7(9), SETD8(6), SETDB1(19), SETDB2(6), SETMAR(4), SMYD3(6), STK38(11), SUV39H1(4), SUV39H2(7), SUV420H1(17), SUV420H2(1), SUZ12(5), WHSC1(28), WHSC1L1(10) 75004455 939 270 822 291 254 209 79 206 179 12 0.178 1.000 1.000 125 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 106 ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADK(7), ADSL(13), ADSS(8), AK1(2), AK5(10), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), ATP1B1(4), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), FHIT(1), GART(5), GDA(7), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NPR1(18), NPR2(17), NT5C(1), NT5E(7), NT5M(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE1A(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6B(11), PDE6C(12), PDE7B(6), PDE8A(6), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), PPAT(8), PRPS1L1(4), PRPS2(6), PRUNE(4), RRM1(3), RRM2(5) 85680138 982 270 935 330 294 148 138 245 156 1 0.230 1.000 1.000 126 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(11), AKT2(8), AKT3(8), BCR(12), BTK(12), CD19(10), CDKN2A(9), DAPP1(3), FLOT1(7), FLOT2(2), GAB1(15), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), PDK1(7), PHF11(3), PITX2(2), PLCG2(28), PPP1R13B(10), PREX1(27), PTEN(333), PTPRC(36), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SAG(5), SYK(8), TEC(10), VAV1(24) 35190298 798 269 662 287 159 272 108 154 96 9 0.437 1.000 1.000 127 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(44), ABCA10(36), ABCA12(82), ABCA13(72), ABCA3(24), ABCA4(35), ABCA5(36), ABCA6(35), ABCA7(22), ABCA8(32), ABCA9(39), ABCB1(35), ABCB10(11), ABCB11(19), ABCB4(28), ABCB5(29), ABCB6(8), ABCB7(7), ABCB8(10), ABCB9(7), ABCC1(25), ABCC10(20), ABCC11(17), ABCC12(27), ABCC2(23), ABCC3(11), ABCC4(24), ABCC5(22), ABCC6(13), ABCC8(25), ABCC9(26), ABCD1(5), ABCD2(21), ABCD3(5), ABCD4(10), ABCG1(8), ABCG2(17), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(21), TAP1(9), TAP2(16) 76282590 984 268 966 304 255 148 112 294 164 11 0.0126 1.000 1.000 128 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 63 ACP1(5), ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BAIAP2(7), CDC42(3), CREBBP(81), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNND1(19), EP300(56), FARP2(13), FER(18), FGFR1(22), FYN(17), IGF1R(22), INSR(21), IQGAP1(31), LEF1(9), LMO7(33), MAP3K7(9), MAPK1(3), MAPK3(4), MLLT4(21), NLK(12), PARD3(13), PTPN1(11), PTPN6(4), PTPRB(21), PTPRF(23), PTPRJ(18), PTPRM(48), PVRL1(9), PVRL2(5), PVRL3(5), PVRL4(11), RAC1(2), RAC2(1), RAC3(2), SNAI1(6), SNAI2(11), SORBS1(15), SRC(3), SSX2IP(9), TCF7(15), TCF7L1(8), TGFBR1(20), TGFBR2(26), TJP1(25), VCL(10), WAS(4), WASF1(6), WASF2(5), WASF3(17), WASL(18), YES1(10) 68485326 953 267 853 328 275 184 116 209 166 3 0.224 1.000 1.000 129 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 111 ARAF(10), BID(2), CASP3(4), CD244(7), CD247(3), CD48(2), FAS(9), FASLG(3), FCGR3A(5), FCGR3B(2), FYN(17), GZMB(5), HCST(2), HLA-C(13), HLA-E(4), HLA-G(13), HRAS(4), ICAM1(4), ICAM2(6), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), ITGAL(21), ITGB2(18), KIR2DL1(10), KIR2DL4(5), KIR3DL1(10), KIR3DL2(7), KLRC1(2), KLRC2(2), KLRC3(8), KLRD1(3), KLRK1(8), LAT(3), LCK(9), LCP2(10), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MICB(4), NCR1(3), NCR2(2), NCR3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), PAK1(11), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRF1(8), PRKCA(8), PRKCG(24), PTK2B(13), PTPN11(41), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), SH2D1A(3), SH2D1B(1), SH3BP2(7), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SYK(8), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFSF10(3), TYROBP(1), ULBP1(7), ULBP2(2), ULBP3(6), VAV1(24), VAV3(30), ZAP70(12) 66576765 842 265 760 304 241 160 99 194 146 2 0.499 1.000 1.000 130 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 43 AKT1(11), AKT2(8), AKT3(8), BRD4(22), CAP1(5), CDC42(3), CDKN2A(9), F2RL2(8), FLOT1(7), FLOT2(2), GSK3A(6), GSK3B(17), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), LNPEP(23), MAPK1(3), MAPK3(4), PARD3(13), PARD6A(2), PDK1(7), PIK3CD(11), PPYR1(8), PTEN(333), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SERPINB6(4), SFN(1), SHC1(14), SLC2A4(8), SORBS1(15), SOS1(16), SOS2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 33506407 748 262 587 257 139 259 93 150 98 9 0.187 1.000 1.000 131 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 75 AIFM1(13), AKT1(11), AKT2(8), AKT3(8), APAF1(27), ATM(237), BAD(1), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CAPN1(2), CAPN2(10), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CSF2RB(13), CYCS(1), DFFA(6), DFFB(2), ENDOG(3), FADD(1), FAS(9), FASLG(3), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL3(6), IRAK1(6), IRAK2(11), IRAK3(11), IRAK4(8), MAP3K14(6), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), NTRK1(17), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), RIPK1(7), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFRSF1A(4), TNFSF10(3), TRAF2(8) 52292264 766 261 660 279 175 195 78 178 132 8 0.750 1.000 1.000 132 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 86 ACTB(4), BAD(1), BCL2(2), CABIN1(24), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(13), CREBBP(81), CSNK2A1(7), CSNK2B(2), CTLA4(5), EGR2(16), EGR3(6), EP300(56), FCER1A(6), FCGR3A(5), FOS(5), FOSL1(1), GATA3(17), GATA4(4), GRLF1(19), GSK3A(6), GSK3B(17), HRAS(4), ICOS(2), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL13(2), IL1B(5), IL2(5), IL2RA(6), IL3(6), IL4(5), IL6(7), IL8(6), ITK(26), KPNA5(12), MAPK14(8), MAPK8(17), MAPK9(13), MEF2A(7), MEF2D(3), MYF5(7), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB2(6), NFKBIB(5), NFKBIE(5), NPPB(5), NUP214(22), OPRD1(6), P2RX7(13), PAK1(11), PIN1(2), PPIA(1), PPP3CB(11), PPP3CC(7), PPP3R1(4), PTPRC(36), RELA(10), RPL13A(1), SFN(1), SLA(8), SP1(7), SP3(13), TGFB1(2), TNF(2), TRAF2(8), TRPV6(20), VAV1(24), VAV3(30), XPO5(8) 57242474 798 260 737 280 242 195 85 164 112 0 0.162 1.000 1.000 133 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 76 ACVR1(9), ACVR2B(14), ACVRL1(8), AMHR2(4), BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BMPR1B(15), CHRD(16), COMP(6), CREBBP(81), CUL1(17), DCN(9), E2F4(2), E2F5(6), EP300(56), FST(5), GDF5(13), GDF6(7), ID1(2), ID4(1), IFNG(3), INHBA(21), INHBB(3), INHBC(4), INHBE(3), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(3), MAPK3(4), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), RBL1(21), RBL2(24), RBX1(1), ROCK1(35), ROCK2(20), RPS6KB1(9), RPS6KB2(6), SKP1(2), SMAD1(10), SMAD5(4), SMAD7(2), SMAD9(7), SMURF1(9), SMURF2(7), SP1(7), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNF(2), ZFYVE16(23), ZFYVE9(23) 59658981 799 260 734 302 262 137 88 177 129 6 0.741 1.000 1.000 134 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 52 BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BTRC(11), CSNK1A1(3), CSNK1A1L(9), CSNK1D(15), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(7), DHH(4), FBXW11(13), GLI1(22), GLI2(28), GLI3(44), GSK3B(17), HHIP(16), IHH(5), LRP2(130), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), PTCH1(143), PTCH2(21), RAB23(4), SHH(3), SMO(13), STK36(20), SUFU(5), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 37232771 699 255 610 259 226 157 82 136 95 3 0.457 1.000 1.000 135 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 30 ACTA1(14), CRKL(5), DOCK1(24), ELK1(4), FOS(5), GAB1(15), HGF(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAP4K1(7), MAPK1(3), MAPK3(4), MAPK8(17), PAK1(11), PTEN(333), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAP1A(2), RAP1B(2), RASA1(24), SOS1(16), SRC(3), STAT3(10) 24721098 642 255 486 260 76 264 81 140 73 8 0.870 1.000 1.000 136 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHX58(6), ENPP1(17), ENPP3(12), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), G6PC(5), G6PC2(3), GAA(14), GANC(9), GBA(4), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), IFIH1(22), LYZL1(4), MGAM(26), MOV10L1(23), NUDT5(1), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SI(28), SKIV2L2(13), SMARCA2(22), SMARCA5(18), TREH(6), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UXS1(9) 85635782 923 252 856 275 257 158 110 220 175 3 0.0469 1.000 1.000 137 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 101 A4GNT(7), ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG6(5), ALG8(13), ALG9(8), B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT5(5), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(10), CHST11(6), CHST12(6), CHST14(1), CHST2(13), CHST3(7), CHST4(8), CHSY1(14), DAD1(3), DDOST(4), EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), FUT11(3), FUT8(11), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GANAB(13), GCNT1(9), GCNT3(6), GCNT4(14), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), NDST1(10), NDST2(10), NDST3(19), NDST4(13), OGT(10), RPN1(4), RPN2(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(6), STT3B(11), UST(12), XYLT1(14) 69881365 834 250 790 316 280 146 90 196 122 0 0.923 1.000 1.000 138 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 82 AKT1(11), AKT2(8), AKT3(8), BCL10(8), CBLB(17), CBLC(3), CD247(3), CD28(5), CD3D(5), CD3E(2), CD4(4), CD40LG(10), CD8A(2), CD8B(4), CDC42(3), CDK4(4), CHUK(27), CTLA4(5), FOS(5), FYN(17), GRAP2(7), HRAS(4), ICOS(2), IFNG(3), IKBKB(9), IKBKG(2), IL10(2), IL2(5), IL4(5), ITK(26), JUN(2), LAT(3), LCK(9), LCP2(10), MALT1(13), MAP3K14(6), MAP3K8(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDCD1(2), PDK1(7), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCQ(16), PTPN6(4), PTPRC(36), RASGRP1(8), SOS1(16), SOS2(17), TEC(10), TNF(2), VAV1(24), VAV3(30), ZAP70(12) 59481116 729 248 675 242 209 148 93 162 117 0 0.118 1.000 1.000 139 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(25), BDKRB1(4), BDKRB2(6), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(17), C2(10), C3(25), C3AR1(12), C4A(3), C4B(2), C4BPA(12), C4BPB(1), C5(25), C5AR1(8), C6(27), C7(11), C8A(14), C8B(23), C8G(1), C9(12), CD46(4), CD55(8), CFB(7), CFH(32), CFI(9), CPB2(11), CR1(20), CR2(22), F10(5), F11(8), F12(5), F13A1(15), F13B(12), F2(10), F2R(11), F3(2), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), KNG1(9), MASP1(23), MASP2(10), MBL2(3), PLAT(11), PLAU(7), PLAUR(9), PLG(27), PROC(3), PROS1(12), SERPINA1(9), SERPINA5(9), SERPINC1(8), SERPIND1(6), SERPINE1(10), SERPINF2(4), SERPING1(7), TFPI(9), THBD(3), VWF(36) 63684208 814 246 775 288 205 132 116 217 140 4 0.598 1.000 1.000 140 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 47 ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(14), CREBBP(81), DUSP1(7), EHHADH(15), EP300(56), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(4), ME1(14), MRPL11(1), MYC(5), NCOA1(15), NCOR1(35), NCOR2(44), NFKBIA(1), NR1H3(16), NR2F1(6), NRIP1(18), PDGFA(2), PPARA(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PTGS2(10), RB1(139), RELA(10), RXRA(8), SP1(7), SRA1(3), STAT5A(10), STAT5B(20), TNF(2) 39451625 642 246 519 221 145 166 58 129 136 8 0.465 1.000 1.000 141 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(4), AKT1(11), AKT2(8), AKT3(8), BAD(1), BTK(12), CDKN2A(9), DAPP1(3), GSK3A(6), GSK3B(17), IARS(10), IGFBP1(2), INPP5D(10), PDK1(7), PPP1R13B(10), PTEN(333), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SOS1(16), SOS2(17), TEC(10), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 22493265 586 242 449 217 83 238 68 112 76 9 0.453 1.000 1.000 142 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(31), ATM(237), ATR(53), CCNA1(18), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), DHFR(1), GSK3B(17), HDAC1(5), RB1(139), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2) 20217609 576 238 441 222 95 203 42 116 101 19 0.744 1.000 1.000 143 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 76 ATF2(7), CHUK(27), CREB1(3), DAXX(18), ELK1(4), FOS(5), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP3K9(11), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAP4K5(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK4(4), MAPK7(6), MAPK8(17), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MKNK2(7), MYC(5), NFKB1(11), NFKBIA(1), PAK1(11), PAK2(15), RAC1(2), RELA(10), RIPK1(7), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KB1(9), RPS6KB2(6), SHC1(14), SP1(7), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8) 58631309 749 238 683 220 203 145 103 160 136 2 0.0178 1.000 1.000 144 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(237), ATR(53), BRCA1(32), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(11), EP300(56), MDM2(11), MYT1(25), PRKDC(85), RPS6KA1(9), YWHAH(5), YWHAQ(1) 26794079 566 237 457 206 100 173 53 124 104 12 0.666 1.000 1.000 145 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 76 ANPEP(19), CD14(6), CD19(10), CD1A(6), CD1B(6), CD1C(5), CD1D(6), CD2(7), CD22(17), CD33(3), CD34(7), CD36(3), CD37(4), CD38(5), CD3D(5), CD3E(2), CD4(4), CD44(6), CD5(9), CD55(8), CD7(6), CD8A(2), CD8B(4), CD9(3), CR1(20), CR2(22), CSF1(5), CSF1R(16), CSF3(3), CSF3R(19), DNTT(13), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(36), FLT3LG(1), GP5(9), GP9(1), GYPA(8), HLA-DRB1(7), HLA-DRB5(4), IL11(6), IL11RA(4), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL2RA(6), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL7(4), IL7R(13), ITGA1(12), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGAM(14), ITGB3(16), KITLG(3), MME(27), MS4A1(7), TFRC(7), THPO(6), TNF(2), TPO(36) 52078117 645 236 596 222 188 103 85 179 86 4 0.132 1.000 1.000 146 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 67 ACACB(40), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ADIPOR1(2), ADIPOR2(6), AKT1(11), AKT2(8), AKT3(8), CAMKK1(2), CAMKK2(9), CD36(3), CHUK(27), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), G6PC(5), G6PC2(3), IKBKB(9), IKBKG(2), IRS1(21), IRS4(36), JAK1(22), JAK3(31), LEP(1), LEPR(21), MAPK10(18), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NPY(6), PCK1(6), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(16), PTPN11(41), RELA(10), RXRA(8), RXRB(8), RXRG(11), SLC2A1(7), SLC2A4(8), STAT3(10), STK11(38), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5) 52844868 728 236 639 227 205 167 95 163 97 1 0.0142 1.000 1.000 147 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 49 ACTG1(6), APAF1(27), ARHGDIB(5), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), GSN(4), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK8(17), MDM2(11), NFKB1(11), NFKBIA(1), NUMA1(26), PAK2(15), PRKCD(15), PRKDC(85), PSEN1(4), PSEN2(6), PTK2(24), RASA1(24), RB1(139), RELA(10), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8) 44528430 682 235 571 224 148 191 58 149 126 10 0.349 1.000 1.000 148 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(11), EIF4A2(12), EIF4G1(19), EIF4G2(16), EIF4G3(19), GHR(12), IRS1(21), MAPK1(3), MAPK14(8), MAPK3(4), MKNK1(4), PABPC1(8), PDK2(9), PDPK1(4), PRKCA(8), PTEN(333), RPS6KB1(9) 16591007 500 234 359 196 55 217 66 97 57 8 0.733 1.000 1.000 149 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(237), BMPR1B(15), CCND2(3), CDK4(4), CDKN1B(6), DAZL(3), DMC1(7), EGR1(14), ESR2(8), FSHR(19), GJA4(3), INHA(6), MLH1(68), MSH5(8), NCOR1(35), NR5A1(5), NRIP1(18), PGR(16), PRLR(10), PTGER2(2), SMPD1(10), VDR(4), ZP2(16) 22763313 517 234 413 177 99 157 44 112 97 8 0.375 1.000 1.000 150 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 92 AKT1(11), AKT2(8), AKT3(8), CASP8(20), CCL4(1), CD14(6), CD40(7), CD80(6), CD86(2), CHUK(27), CXCL10(2), CXCL11(4), CXCL9(7), FADD(1), FOS(5), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IKBKB(9), IKBKE(9), IKBKG(2), IL12A(2), IL12B(1), IL1B(5), IL6(7), IL8(6), IRAK1(6), IRAK4(8), IRF3(4), IRF5(6), JUN(2), LBP(8), LY96(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K7(9), MAP3K8(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), RAC1(2), RELA(10), RIPK1(7), SPP1(4), STAT1(17), TBK1(12), TICAM1(15), TIRAP(5), TLR1(11), TLR2(12), TLR3(15), TLR4(18), TLR5(9), TLR6(14), TLR7(18), TLR8(20), TLR9(16), TNF(2), TOLLIP(5), TRAF3(12), TRAF6(4) 55882965 699 229 660 221 177 124 80 195 121 2 0.175 1.000 1.000 151 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(11), EIF4A2(12), EIF4B(5), EIF4G1(19), EIF4G2(16), EIF4G3(19), FKBP1A(2), MKNK1(4), PDK2(9), PDPK1(4), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9), TSC1(18), TSC2(17) 15782744 484 229 346 192 56 220 55 85 60 8 0.721 1.000 1.000 152 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ALG6(5), CCKBR(16), CCR2(7), CCR3(11), CCR5(11), CELSR1(28), CELSR2(33), CELSR3(28), CHRM2(29), CHRM3(23), CIDEB(1), CXCR3(5), EDNRA(9), EMR2(11), EMR3(19), F2R(11), FSHR(19), GHRHR(2), GNRHR(9), GPR116(21), GPR132(6), GPR133(16), GPR143(4), GPR17(3), GPR18(5), GPR55(2), GPR56(6), GPR61(12), GPR77(4), GPR84(8), GPR88(4), GRM1(37), GRPR(4), HRH4(6), LGR6(9), LPHN2(30), LPHN3(30), NTSR1(5), OR2M4(17), OR8G1(3), OR8G2(9), PTGFR(8), SMO(13), SSTR2(6), TAAR5(10), VN1R1(7) 38404100 562 228 505 207 179 106 52 140 84 1 0.543 1.000 1.000 153 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(11), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), GSK3B(17), IGF1(6), IGF1R(22), INPPL1(16), PDK2(9), PDPK1(4), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9) 10971766 456 227 319 186 45 223 54 76 50 8 0.875 1.000 1.000 154 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 18 ATM(237), ATR(53), BRCA1(32), BRCA2(99), CHEK1(11), FANCA(12), FANCC(8), FANCE(4), FANCF(4), FANCG(7), HUS1(8), MRE11A(20), RAD1(2), RAD17(9), RAD50(30), RAD9A(1), TREX1(3) 27772822 540 226 420 202 67 169 44 137 111 12 0.892 1.000 1.000 155 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CDK2(5), CDK4(4), CHEK1(11), MYT1(25), RB1(139), YWHAH(5) 11283140 454 223 335 156 73 171 29 99 66 16 0.291 1.000 1.000 156 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 61 ADAM10(8), ADAM17(13), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), CASP3(4), CDC42(3), CHUK(27), CSK(5), CXCL1(1), F11R(4), GIT1(4), HBEGF(1), IGSF5(16), IKBKB(9), IKBKG(2), IL8(6), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NOD1(10), PAK1(11), PLCG1(19), PLCG2(28), PTPN11(41), PTPRZ1(43), RAC1(2), RELA(10), SRC(3), TCIRG1(7), TJP1(25) 43103119 529 221 466 169 135 140 64 120 69 1 0.0819 1.000 1.000 157 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(11), BCAR1(6), CDKN1B(6), ILK(3), ITGB1(13), MAPK1(3), MAPK3(4), PDK2(9), PDPK1(4), PTEN(333), PTK2(24), SHC1(14), SOS1(16) 9918770 446 221 310 175 30 214 56 80 57 9 0.732 1.000 1.000 158 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(11), AKT2(8), AKT3(8), BPNT1(9), ILK(3), MAPK1(3), MAPK3(4), PDK1(7), PIK3CD(11), PTEN(333), PTK2B(13), RBL2(24), SHC1(14), SOS1(16) 11890511 464 221 327 176 42 212 57 88 56 9 0.757 1.000 1.000 159 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(27), ATM(237), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDKN1A(2), MDM2(11), PCNA(5), RB1(139), TIMP3(11) 11838531 451 215 326 168 61 176 30 99 69 16 0.562 1.000 1.000 160 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 60 AGTR1(14), AGTR2(17), ATP8A1(16), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CX3CR1(6), CXCR3(5), CXCR4(7), CXCR6(1), EDNRA(9), EDNRB(19), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(4), GRPR(4), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), NMBR(4), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), PPYR1(8), SSTR1(12), SSTR2(6), SSTR4(14), TAC4(4), TACR1(9), TACR2(4), TACR3(18), TRHR(9) 31395115 502 215 459 196 179 96 53 126 48 0 0.370 1.000 1.000 161 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 35 AKT1(11), ASAH1(4), ATF1(6), CAMP(1), CREB1(3), CREB3(6), CREB5(8), CREBBP(81), CRKL(5), DAG1(10), EGR1(14), EGR2(16), EGR3(6), EGR4(3), ELK1(4), FRS2(6), GNAQ(11), JUN(2), MAP1B(51), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NTRK1(17), OPN1LW(4), PIK3C2G(21), PIK3CD(11), PTPN11(41), RPS6KA3(16), SHC1(14), SRC(3), TERF2IP(4) 28006832 452 206 402 193 104 99 58 109 79 3 0.968 1.000 1.000 162 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(11), APAF1(27), ATM(237), BAD(1), BCL2(2), BCL2L1(1), BID(2), CASP3(4), CASP6(3), CASP7(3), CASP9(6), CYCS(1), EIF2S1(3), PRKCA(8), PTK2(24), PXN(2), STAT1(17), TLN1(23) 18172119 375 204 297 155 61 127 36 83 59 9 0.947 1.000 1.000 163 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 39 ADAM17(13), APH1A(2), CREBBP(81), CTBP1(5), CTBP2(14), DLL1(10), DLL3(7), DLL4(7), DTX1(6), DTX2(10), DTX3(3), DTX3L(11), DTX4(8), DVL2(12), DVL3(10), EP300(56), HDAC1(5), HDAC2(8), HES1(2), JAG1(16), LFNG(6), MAML1(12), MAML2(9), MAML3(4), MFNG(1), NCOR2(44), NCSTN(6), NOTCH2(35), NOTCH3(31), NOTCH4(20), NUMB(10), NUMBL(6), PSEN1(4), PSEN2(6), PSENEN(2), PTCRA(5), RBPJL(11), RFNG(1), SNW1(10) 37843484 509 204 453 230 151 98 62 88 109 1 0.995 1.000 1.000 164 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 64 AKT1(11), AKT2(8), AKT3(8), BTK(12), FCER1A(6), FYN(17), GAB2(10), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(10), LAT(3), LCP2(10), LYN(13), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MS4A2(6), PDK1(7), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PRKCA(8), PRKCD(15), PRKCE(6), RAC1(2), RAC2(1), RAC3(2), SOS1(16), SOS2(17), SYK(8), TNF(2), VAV1(24), VAV3(30) 41513462 534 204 504 178 160 110 68 125 71 0 0.133 1.000 1.000 165 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(14), AKT1(11), BDKRB2(6), CALM2(1), CALM3(1), CAV1(1), CHRM1(4), CHRNA1(12), FLT1(43), FLT4(18), KDR(42), NOS3(23), PDE2A(10), PDE3A(21), PDE3B(10), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKG1(18), PRKG2(12), RYR2(138), SLC7A1(6), SYT1(14), TNNI1(2) 25500072 442 203 424 158 119 97 52 112 60 2 0.395 1.000 1.000 166 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(31), ATM(237), BRCA1(32), CDKN1A(2), CHEK1(11), JUN(2), MAPK8(17), MDM2(11), MRE11A(20), NFKB1(11), NFKBIA(1), RAD50(30), RBBP8(15), RELA(10), TP73(5) 19029331 435 201 343 177 69 148 32 95 82 9 0.974 1.000 1.000 167 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 52 AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CAT(8), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADHA(12), KMO(16), KYNU(9), MAOA(7), MAOB(9), SDS(3), TDO2(11), TPH1(4), WARS(4), WARS2(7) 37067885 469 200 443 141 155 84 50 127 52 1 0.0340 1.000 1.000 168 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(7), AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PRIM1(5), PRIM2(3), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), TK1(2), TK2(3), TXNRD1(9), TXNRD2(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UPB1(9), UPP1(5), UPP2(6), UPRT(7) 56169458 575 199 549 165 152 92 91 153 87 0 0.00515 1.000 1.000 169 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 62 AKT1(11), AKT2(8), AKT3(8), BAD(1), CASP9(6), CDC42(3), HRAS(4), KDR(42), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPKAPK2(5), MAPKAPK3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NOS3(23), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCA(8), PRKCG(24), PTGS2(10), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), SH2D2A(5), SHC2(2), SPHK1(3), SPHK2(5), SRC(3), VEGFA(5) 41750426 487 199 448 195 174 75 60 98 80 0 0.806 1.000 1.000 170 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 56 AKT1(11), AKT2(8), AKT3(8), BCL10(8), BLNK(2), BTK(12), CD19(10), CD22(17), CD72(4), CD79A(6), CD79B(3), CHUK(27), CR2(22), FCGR2B(2), FOS(5), GSK3B(17), HRAS(4), IFITM1(2), IKBKB(9), IKBKG(2), INPP5D(10), JUN(2), LILRB3(8), LYN(13), MALT1(13), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RASGRP3(9), SYK(8), VAV1(24), VAV3(30) 43111326 507 199 476 163 162 89 67 112 77 0 0.0574 1.000 1.000 171 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(5), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CFLAR(3), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), PTPN13(23), RB1(139), RIPK2(5), SPTAN1(30) 26633770 455 198 384 160 71 136 38 114 86 10 0.749 1.000 1.000 172 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 51 AXIN1(10), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), DVL2(12), DVL3(10), FBXW2(6), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LDLR(11), MAPK10(18), MAPK9(13), MYC(5), PAFAH1B1(6), PLAU(7), PPP2R5C(6), PPP2R5E(8), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), RAC1(2), SFRP4(9), TCF7(15), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4) 30538721 470 197 428 172 166 98 47 83 75 1 0.286 1.000 1.000 173 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 15 ABCB1(35), AKT1(11), ATM(237), CDKN1A(2), CPB2(11), CSNK1A1(3), CSNK1D(15), FHL2(3), HIF1A(16), IGFBP3(8), MAPK8(17), MDM2(11), NFKBIB(5), NQO1(1) 12809774 375 195 300 125 59 128 34 91 55 8 0.314 1.000 1.000 174 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 53 ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), CARM1(3), DBH(9), DCT(22), DDC(5), ECH1(2), ESCO1(22), ESCO2(18), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HEMK1(1), HGD(6), HPD(7), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), MYST3(34), MYST4(33), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SH3GLB1(6), TAT(16), TPO(36), TYR(12), TYRP1(6), WBSCR22(2) 39403230 474 194 426 176 135 95 56 124 63 1 0.565 1.000 1.000 175 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 55 AADAT(2), AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), AFMID(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CARM1(3), CAT(8), CYP1A1(10), CYP1A2(11), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADH(2), HADHA(12), HEMK1(1), HSD17B10(3), HSD17B4(9), INMT(4), KMO(16), KYNU(9), LCMT1(1), LCMT2(6), LNX1(19), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), NFX1(11), OGDH(14), OGDHL(16), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), TDO2(11), TPH1(4), TPH2(12), WARS(4), WARS2(7), WBSCR22(2) 40159518 432 193 411 152 132 72 56 117 55 0 0.419 1.000 1.000 176 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CD2BP2(7), CDC40(7), CLK2(3), CLK3(8), COL2A1(20), CPSF1(15), CPSF2(10), CPSF3(9), CPSF4(5), CSTF1(5), CSTF2(2), CSTF2T(14), CSTF3(13), DDIT3(5), DDX1(15), DDX20(7), DHX15(10), DHX16(20), DHX38(14), DHX9(13), DICER1(25), DNAJC8(5), FUS(2), GIPC1(4), LSM2(1), METTL3(6), NCBP1(12), NCBP2(2), NONO(13), NUDT21(1), NXF1(11), PABPN1(2), PAPOLA(8), PHF5A(1), POLR2A(14), PPM1G(4), PRPF18(5), PRPF3(9), PRPF4(10), PRPF4B(22), PRPF8(19), PSKH1(2), PTBP1(4), PTBP2(14), RBM17(6), RBM5(15), RNGTT(7), RNMT(6), RNPS1(2), SF3A1(11), SF3A2(5), SF3A3(1), SF3B1(18), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(3), SNRPA1(2), SNRPB(3), SNRPB2(3), SNRPD1(2), SNRPD3(2), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(9), SRPK2(12), SRRM1(18), SUPT5H(20), TXNL4A(2), U2AF1(4), U2AF2(8), XRN2(12) 69448641 603 193 568 195 161 89 64 159 129 1 0.811 1.000 1.000 177 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 25 ARHGDIB(5), CASP2(8), CASP3(4), CASP8(20), CRADD(4), DFFA(6), DFFB(2), FADD(1), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MADD(26), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), RB1(139), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TRAF2(8) 24411734 441 193 369 153 88 126 32 100 84 11 0.635 1.000 1.000 178 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 41 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), BCR(12), BLNK(2), BTK(12), CD19(10), CD22(17), CR2(22), CSK(5), DAG1(10), FLOT1(7), FLOT2(2), GSK3A(6), GSK3B(17), INPP5D(10), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP4K1(7), MAPK1(3), MAPK3(4), NFATC2(12), PDK1(7), PIK3CD(11), PLCG2(28), PPP1R13B(10), PPP3CA(5), PPP3CB(11), PPP3CC(7), PTPRC(36), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24) 43688973 531 190 511 156 168 93 69 119 80 2 0.00950 1.000 1.000 179 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(7), ACADL(6), ACADM(12), ACOX1(11), ACOX2(8), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP27A1(4), CYP4A11(8), CYP4A22(13), CYP7A1(14), CYP8B1(10), DBI(2), EHHADH(15), FABP1(2), FABP2(9), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FABP7(1), FADS2(12), GK(5), GK2(16), HMGCS2(6), ILK(3), LPL(12), ME1(14), MMP1(6), NR1H3(16), PCK1(6), PCK2(6), PDPK1(4), PLTP(12), PPARA(7), PPARD(5), PPARG(4), RXRA(8), RXRB(8), RXRG(11), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(7), SLC27A4(3), SLC27A5(9), SLC27A6(20), SORBS1(15), UBC(7), UCP1(8) 44220571 507 189 468 144 162 67 75 131 72 0 0.00655 1.000 1.000 180 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 APAF1(27), BAD(1), BAK1(2), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(18), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), GZMB(5), HELLS(13), IKBKB(9), IKBKG(2), IRF1(6), IRF2(10), IRF3(4), IRF4(5), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(21), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), NFKBIB(5), NFKBIE(5), PLEKHG5(9), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF10B(8), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFSF10(3), TP73(5), TRAF1(7), TRAF2(8), TRAF3(12) 36193873 427 187 378 132 104 85 48 96 94 0 0.239 1.000 1.000 181 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 45 ACTA1(14), AGT(12), AKT1(11), CALM2(1), CALM3(1), CALR(2), CAMK1G(7), CAMK4(9), CREBBP(81), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(10), FGF2(5), FKBP1A(2), GATA4(4), GSK3B(17), HAND1(5), HAND2(2), HRAS(4), IGF1(6), LIF(1), MAP2K1(12), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MEF2C(15), MYH2(42), NFATC2(12), NFATC3(15), NFATC4(12), NPPA(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KB1(9), SYT1(14) 28827813 424 187 393 153 125 94 45 93 66 1 0.384 1.000 1.000 182 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(32), CARM1(3), CCND1(2), CREBBP(81), EP300(56), ERCC3(19), ESR1(21), GRIP1(15), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), MEF2C(15), NCOR2(44), NR0B1(11), NRIP1(18), PELP1(11), POLR2A(14), SRA1(3), TBP(2) 31101277 431 186 375 191 113 89 45 82 102 0 0.997 1.000 1.000 183 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 59 ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CHPT1(4), CRLS1(1), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), ESCO1(22), ESCO2(18), ETNK1(3), GPAM(5), GPD1(3), GPD1L(5), GPD2(11), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(34), MYST4(33), NAT6(2), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(14), SH3GLB1(6) 41793491 460 185 428 183 141 74 65 120 59 1 0.871 1.000 1.000 184 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 66 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1C1(2), AKR1C2(3), AKR1C3(2), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), CYP1A1(10), CYP1A2(11), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2F1(7), CYP2S1(8), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9) 37362907 438 185 398 123 110 83 47 124 73 1 0.0285 1.000 1.000 185 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(42), AR(26), ESR1(21), ESR2(8), HNF4A(12), NPM1(3), NR0B1(11), NR1D1(8), NR1D2(10), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(5), NR2C2(11), NR2E1(13), NR2F1(6), NR2F2(11), NR3C1(11), NR4A1(3), NR4A2(16), NR5A1(5), NR5A2(9), PGR(16), PPARA(7), PPARD(5), PPARG(4), RARA(6), RARB(20), RARG(10), ROR1(23), RORA(6), RORC(6), RXRA(8), RXRB(8), RXRG(11), THRA(6), THRB(14), VDR(4) 26843553 406 185 379 136 138 71 47 91 57 2 0.247 1.000 1.000 186 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 34 AKT1(11), ATF2(7), CDC42(3), DLD(4), DUSP10(6), DUSP4(6), GAB1(15), GCK(6), IL1R1(7), JUN(2), MAP2K5(6), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK10(18), MAPK7(6), MAPK8(17), MAPK9(13), MYEF2(14), NFATC3(15), NR2C2(11), PAPPA(39), SHC1(14), TRAF6(4), ZAK(12) 32319345 424 185 371 116 113 69 54 97 89 2 0.0503 1.000 1.000 187 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CHEK1(11), MYT1(25), YWHAH(5) 9066004 306 183 239 104 53 106 22 71 46 8 0.367 1.000 1.000 188 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 53 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AGK(7), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CEL(13), DAK(8), DGAT1(5), DGAT2(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), GK(5), GK2(16), GLA(7), GLB1(9), GPAM(5), LCT(46), LIPA(3), LIPC(6), LIPF(3), LIPG(4), LPL(12), MGLL(2), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 38380264 456 183 425 177 129 66 65 143 52 1 0.748 1.000 1.000 189 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(237), ATR(53), CDC25C(6), CHEK1(11), YWHAH(5) 10199994 312 183 233 111 43 106 23 67 62 11 0.636 1.000 1.000 190 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 88 ANK2(84), B3GALT4(4), CDR1(8), DGKI(22), FAU(2), IL6ST(15), MRPL19(4), PIGK(12), RPL10(3), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(6), RPL6(4), RPL7(4), RPL7A(1), RPL8(3), RPL9(4), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(2), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS4X(3), RPS5(2), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), RPS7(1), RPS9(3), RPSA(1), SLC36A2(6), TSPAN9(5), UBA52(3), UBB(3), UBC(7) 33919000 378 181 355 108 98 76 51 94 57 2 0.122 1.000 1.000 191 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(81), DAXX(18), HRAS(4), PAX3(26), PML(12), RARA(6), RB1(139), SIRT1(8), SP100(15), TNF(2), TNFRSF1A(4), TNFRSF1B(1) 11937104 316 180 243 121 73 113 23 52 47 8 0.572 1.000 1.000 192 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 40 CD28(5), CD3D(5), CSK(5), CTLA4(5), DAG1(10), DTYMK(1), EPHB2(16), GRAP2(7), ITK(26), ITPKA(3), ITPKB(15), LAT(3), LCK(9), LCP2(10), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLCG1(19), PTPRC(36), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), SOS1(16), SOS2(17), VAV1(24), ZAP70(12) 32595830 396 179 374 134 105 89 49 89 64 0 0.303 1.000 1.000 193 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 39 AKT1(11), AKT2(8), AKT3(8), CAB39(2), EIF4B(5), FIGF(6), HIF1A(16), IGF1(6), MAPK1(3), MAPK3(4), PDPK1(4), PGF(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PRKAA1(9), PRKAA2(20), RHEB(5), RICTOR(27), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), STK11(38), TSC1(18), TSC2(17), ULK2(14), ULK3(3), VEGFA(5), VEGFC(15) 29798905 407 175 374 145 120 83 50 89 63 2 0.519 1.000 1.000 194 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 38 BCL2(2), CHUK(27), DAXX(18), EGF(8), ETS1(10), ETS2(5), FOS(5), HOXA7(4), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK1(3), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), NFKB1(11), NFKBIA(1), PPP2CA(3), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), RELA(10), RIPK1(7), SP1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 29381813 340 175 306 119 100 88 39 72 41 0 0.319 1.000 1.000 195 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHFR(1), DHX58(6), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), FPGS(4), GGH(2), IFIH1(22), MOV10L1(23), NUDT5(1), QDPR(2), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SKIV2L2(13), SMARCA2(22), SMARCA5(18), SPR(7) 42240555 478 174 432 156 149 83 53 106 85 2 0.327 1.000 1.000 196 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 44 ACCN1(14), ADCY4(14), ADCY6(13), ADCY8(34), CACNA1A(28), CACNA1B(40), GNAT3(4), GNB1(3), GNB3(6), GNG3(2), GRM4(15), ITPR3(44), KCNB1(22), PDE1A(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), SCNN1A(8), SCNN1B(8), SCNN1G(12), TAS1R1(13), TAS1R2(22), TAS2R1(5), TAS2R10(10), TAS2R13(9), TAS2R14(2), TAS2R16(7), TAS2R3(6), TAS2R38(7), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R43(3), TAS2R46(1), TAS2R5(4), TAS2R50(10), TAS2R60(4), TAS2R7(4), TAS2R8(9), TAS2R9(3), TRPM5(5) 32826317 431 173 429 158 159 53 44 101 73 1 0.697 1.000 1.000 197 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP12A(35), ATP4A(20), ATP4B(3), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5L(2), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), COX10(6), COX15(8), COX17(1), COX4I1(5), COX4I2(4), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(6), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(3), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(8), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(4), NDUFC1(1), NDUFC2(2), NDUFS1(16), NDUFS2(6), NDUFS3(4), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(5), PPA1(3), PPA2(5), SDHA(14), SDHB(3), SDHD(4), TCIRG1(7), UQCRB(2), UQCRC1(4), UQCRC2(13), UQCRFS1(3), UQCRH(1) 37963328 433 172 398 129 142 89 52 83 67 0 0.0120 1.000 1.000 198 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), F10(5), F11(8), F12(5), F2(10), F2R(11), F5(37), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), PROC(3), PROS1(12), SERPINC1(8), SERPING1(7) 31265399 375 172 347 149 83 72 55 99 64 2 0.679 1.000 1.000 199 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(27), CREBBP(81), DUSP1(7), EP300(56), IKBKB(9), IL1B(5), IL8(6), MAP2K3(11), MAP2K6(5), MAP3K14(6), MAP3K7(9), MAPK14(8), MYD88(4), NFKB1(11), NFKBIA(1), NR3C1(11), RELA(10), TGFBR1(20), TGFBR2(26), TLR2(12), TNF(2) 20033236 327 172 281 114 87 98 34 63 44 1 0.294 1.000 1.000 200 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTG2(6), ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), CDC42(3), CFL1(2), CFL2(2), FLNA(31), FLNC(39), FSCN1(5), FSCN3(6), GDI1(1), GDI2(2), LIMK1(8), MYH2(42), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PFN2(4), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), VASP(4), WASF1(6), WASL(18) 30035145 406 171 373 137 120 63 49 89 80 5 0.286 1.000 1.000 201 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ENPP1(17), ENPP3(12), G6PC(5), GAA(14), GANAB(13), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), MGAM(26), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), SI(28), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UXS1(9) 40341344 392 171 375 118 112 71 49 83 76 1 0.123 1.000 1.000 202 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(2), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), HSD3B7(3), NSD1(29), OGDH(14), OGDHL(16), PIPOX(9), PLOD1(8), PLOD2(10), PLOD3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SETD1A(21), SETD7(9), SETDB1(19), SHMT1(7), SHMT2(5), SPCS1(3), SPCS3(2), SUV39H1(4), SUV39H2(7), TMLHE(6) 37622270 386 170 359 119 133 56 39 91 67 0 0.160 1.000 1.000 203 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 49 ALG2(8), BAK1(2), BTK(12), CAD(23), CASP10(7), CASP3(4), CASP8(20), CASP8AP2(30), CD7(6), CSNK1A1(3), DAXX(18), DEDD(3), DEDD2(1), DFFA(6), DIABLO(3), EPHB2(16), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(6), MAP3K1(21), MAP3K5(16), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PFN2(4), PTPN13(23), RALBP1(8), RIPK1(7), ROCK1(35), SMPD1(10), TPX2(10), TRAF2(8), TUFM(6) 40141860 438 170 411 137 104 84 44 123 77 6 0.341 1.000 1.000 204 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 43 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), CEL(13), DGAT1(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), GK(5), GLA(7), GLB1(9), LCT(46), LIPC(6), LIPF(3), LIPG(4), LPL(12), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 31169452 392 169 363 143 110 66 55 114 46 1 0.454 1.000 1.000 205 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 47 ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3) 31281573 394 169 360 151 115 64 47 89 75 4 0.697 1.000 1.000 206 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 47 ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3) 31281573 394 169 360 151 115 64 47 89 75 4 0.697 1.000 1.000 207 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(9), ACOX1(11), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP4A11(8), CYP4A22(13), DCI(4), ECHS1(4), EHHADH(15), GCDH(8), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), PECI(2) 32984795 377 166 348 117 101 67 61 97 51 0 0.0353 1.000 1.000 208 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 20 CPEB1(10), ERBB4(65), ETS1(10), ETS2(5), ETV6(11), ETV7(3), MAP2K1(12), MAPK1(3), MAPK3(4), NOTCH2(35), NOTCH3(31), NOTCH4(20), PIWIL1(31), PIWIL2(16), PIWIL3(15), PIWIL4(10), SOS1(16), SOS2(17), SPIRE1(6), SPIRE2(9) 24189263 329 165 304 98 91 53 52 83 50 0 0.121 1.000 1.000 209 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 66 CALR(2), CANX(5), CD4(4), CD74(3), CD8A(2), CD8B(4), CIITA(18), CREB1(3), CTSB(6), CTSL1(8), CTSS(4), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), HSP90AA1(9), HSP90AB1(4), HSPA5(5), IFI30(3), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(10), KIR2DL4(5), KIR2DS4(4), KIR3DL1(10), KIR3DL2(7), KIR3DL3(11), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LGMN(3), LTA(1), NFYA(5), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(15), RFXANK(1), RFXAP(5), TAP1(9), TAP2(16), TAPBP(6) 27307902 355 165 331 116 66 67 45 99 66 12 0.416 1.000 1.000 210 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 28 AKT1(11), AR(26), ASAH1(4), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(10), GNA11(8), GNA15(6), GNAI1(5), GNAQ(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), MAPK10(18), MAPK14(8), PHKA2(19), PIK3CD(11), PITX2(2), PTX3(3), SRC(3) 24661654 338 165 329 119 113 54 40 87 43 1 0.245 1.000 1.000 211 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(11), BCL2(2), IGF1R(22), MYC(5), POLR2A(14), PPP2CA(3), PRKCA(8), RB1(139), TEP1(29), TERF1(6), TERT(10), TNKS(11), XRCC5(13) 16774886 273 164 212 104 60 89 25 46 45 8 0.636 1.000 1.000 212 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), RB1(139), RBL1(21), TFDP1(10) 10864390 263 163 207 100 47 86 20 61 41 8 0.548 1.000 1.000 213 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(27), BAD(1), BCL2(2), BCL2A1(5), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CD40(7), CD40LG(10), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), IKBKE(9), LTA(1), NFKB1(11), NFKBIA(1), NGFR(5), NR3C1(11), NTRK1(17), PTPN13(23), RIPK1(7), SFRS2IP(3), TFG(8), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12), TRAF6(4) 28624864 303 162 276 144 66 78 30 67 62 0 0.999 1.000 1.000 214 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 29 AKT1(11), AKT2(8), AKT3(8), ASAH1(4), DAG1(10), DRD2(9), EPHB2(16), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PI3(3), PIK3CB(6), PITX2(2), PLCB1(23), PLCB3(15), PLCB4(23), RGS20(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT3(10), TERF2IP(4) 33333231 399 162 379 119 127 66 49 92 63 2 0.0628 1.000 1.000 215 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 57 A4GALT(6), ABO(7), B3GALNT1(6), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(5), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT6(10), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GBGT1(1), GCNT2(26), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGX(4), PIGZ(6), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(16), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10), UGCG(9) 30606997 365 161 334 122 113 65 28 96 62 1 0.536 1.000 1.000 216 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(8), ACAA1(7), ACAA2(4), ACADM(12), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), AOX1(15), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(4), ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HADHB(10), HIBADH(2), HIBCH(3), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), OXCT2(3), PCCA(17), PCCB(6) 29680255 312 158 286 81 94 51 39 66 61 1 0.0120 1.000 1.000 217 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 20 IMPA1(4), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MIOX(3), OCRL(21), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CB(6), PIK3CG(41), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28) 26270900 331 158 302 102 107 61 40 73 49 1 0.211 1.000 1.000 218 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ITPA(6), NME1(1), NT5C(1), NT5E(7), NT5M(3), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), RRM1(3), RRM2(5), TK1(2), TK2(3), TXNRD1(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UNG(3), UPB1(9), UPP1(5) 38761888 391 158 374 123 108 63 58 110 52 0 0.131 1.000 1.000 219 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ABP1(4), AGMAT(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH4A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), GAMT(6), GATM(2), GLUD1(4), GOT1(7), GOT2(2), MAOA(7), MAOB(9), NOS1(31), NOS3(23), OAT(4), ODC1(8), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(6), RARS(9), SMS(4) 28972408 356 157 325 116 122 53 45 80 56 0 0.208 1.000 1.000 220 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(6), GTF2A1L(13), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F1(7), GTF2F2(1), GTF2H1(6), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(19), TAF1(32), TAF10(1), TAF12(4), TAF13(3), TAF1L(66), TAF2(20), TAF4(11), TAF4B(11), TAF5(13), TAF5L(3), TAF6(9), TAF6L(5), TAF7(3), TAF7L(14), TAF9(3), TAF9B(1), TBPL1(3), TBPL2(2) 24723511 280 157 253 85 72 52 32 79 44 1 0.209 1.000 1.000 221 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 10 AXIN1(10), CREBBP(81), EP300(56), FZD1(9), GSK3B(17), HDAC1(5), LDB1(9), LEF1(9), PITX2(2), TRRAP(70) 16552447 268 156 233 101 81 78 34 34 40 1 0.304 1.000 1.000 222 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(4), AKT1(11), ASAH1(4), CAMP(1), CAV3(4), DAG1(10), DLG4(10), EPHB2(16), GNAI1(5), GNAQ(11), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(5), RYR1(70) 26282735 327 156 323 133 135 47 41 67 35 2 0.598 1.000 1.000 223 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(30), EEF1A2(8), EEF1B2(3), EEF1D(12), EEF1G(1), EEF2(7), EEF2K(11), EIF1AX(1), EIF2AK1(16), EIF2AK2(5), EIF2AK3(14), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF4A2(12), EIF4EBP2(4), EIF4G1(19), EIF4G3(19), EIF5(6), EIF5A(3), EIF5B(20), ETF1(13), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(23), PAIP1(7), SLC35A4(3) 29310599 313 156 268 82 71 72 29 70 71 0 0.0443 1.000 1.000 224 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 34 AGT(12), AGTR2(17), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDK5(3), F2(10), FYN(17), GNA11(8), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MAPT(11), MYLK(33), PLCG1(19), PRKCA(8), PTK2B(13), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), SYT1(14) 25840982 321 155 287 119 86 63 40 74 57 1 0.691 1.000 1.000 225 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 45 ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPS(6), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CLC(3), CPT1B(14), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), ETNK1(3), GPD1(3), GPD2(11), LCAT(4), LGALS13(5), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(7), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPAP2A(2), PPAP2B(2), PPAP2C(3) 29422770 336 155 315 135 126 42 46 78 44 0 0.816 1.000 1.000 226 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 60 ACSS1(7), ACSS2(10), ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), G6PC2(3), GALM(3), GAPDH(2), GAPDHS(3), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 37011433 385 155 359 141 130 58 40 103 54 0 0.539 1.000 1.000 227 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(8), ADC(3), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EARS2(3), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GFPT2(12), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), GMPS(16), GNPNAT1(1), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSR(5), GSS(9), NADSYN1(4), NAGK(7), PPAT(8), QARS(14) 27172490 303 155 281 83 85 59 37 85 37 0 0.0280 1.000 1.000 228 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 35 CALM2(1), CALM3(1), CD3D(5), CD3E(2), ELK1(4), FOS(5), FYN(17), HRAS(4), JUN(2), LAT(3), LCK(9), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), PTPN7(4), RAC1(2), RASA1(24), RELA(10), SHC1(14), SOS1(16), SYT1(14), VAV1(24), ZAP70(12) 27010267 328 155 295 107 108 66 28 62 63 1 0.254 1.000 1.000 229 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 32 ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), BCR(12), CAPN1(2), CAPNS1(4), CAPNS2(4), CAV1(1), CRKL(5), CSK(5), FYN(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MAPK8(17), PTK2(24), PXN(2), RAP1A(2), ROCK1(35), SHC1(14), SOS1(16), SRC(3), TLN1(23), VCL(10), ZYX(5) 27987052 312 154 288 118 90 49 40 74 53 6 0.740 1.000 1.000 230 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), DAG1(10), DGKA(8), ETFA(5), GCA(1), ITGA9(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAPK1(3), MAPK3(4), NR1I3(5), PAK1(11), PDE3A(21), PDE3B(10), PI3(3), PIK3C2G(21), PIK3CD(11), PLDN(1), PSME1(1), RIPK3(6), RPS4X(3), SGCB(7), VASP(4) 29292484 346 154 339 117 103 57 40 88 55 3 0.338 1.000 1.000 231 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(11), CREB1(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NFKB1(11), RB1(139), RELA(10), SP1(7) 10984766 248 153 191 79 51 80 22 55 32 8 0.138 1.000 1.000 232 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), ESCO1(22), ESCO2(18), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), PRDX6(5), SH3GLB1(6), TAT(16), TPO(36) 22992331 317 153 275 103 110 53 37 69 47 1 0.189 1.000 1.000 233 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 30 ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), DBH(9), DCT(22), DDC(5), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HGD(6), HPD(7), MAOA(7), MAOB(9), PNMT(3), TAT(16), TPO(36), TYR(12) 20736047 272 153 238 100 87 52 33 69 31 0 0.363 1.000 1.000 234 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1D1(9), ARSD(9), ARSE(4), CARM1(3), CYP11B1(17), CYP11B2(7), CYP19A1(11), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), WBSCR22(2) 32604910 336 151 323 104 87 58 41 85 65 0 0.127 1.000 1.000 235 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(2), CREBBP(81), EP300(56), FYN(17), IL2RG(9), IL7(4), IL7R(13), JAK1(22), JAK3(31), LCK(9), NMI(4), PTK2B(13), STAT5A(10), STAT5B(20) 16681528 291 151 240 100 68 78 26 59 59 1 0.548 1.000 1.000 236 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(31), CDKN2A(9), MDM2(11), MYC(5), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), RAC1(2), RB1(139), TWIST1(3) 10046585 242 149 187 84 48 89 25 43 29 8 0.220 1.000 1.000 237 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 49 ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 31165984 339 149 313 119 114 58 35 89 43 0 0.336 1.000 1.000 238 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 49 ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 31165984 339 149 313 119 114 58 35 89 43 0 0.336 1.000 1.000 239 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 22 ARNT(9), EIF1(2), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), ELAVL1(5), FLT1(43), FLT4(18), HIF1A(16), HRAS(4), KDR(42), NOS3(23), PLCG1(19), PRKCA(8), PTK2(24), PXN(2), SHC1(14) 19535415 272 149 229 104 62 70 31 55 53 1 0.853 1.000 1.000 240 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 31 ABAT(8), ACACA(36), ACACB(40), ACADM(12), ACAT1(7), ACAT2(9), ACSS1(7), ACSS2(10), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), HIBCH(3), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SUCLA2(9), SUCLG1(3), SUCLG2(1) 26862918 311 148 289 68 96 37 47 75 56 0 0.000628 1.000 1.000 241 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(7), IFNG(3), IFNGR1(8), IFNGR2(5), IKBKB(9), LIN7A(7), NFKB1(11), NFKBIA(1), RB1(139), RELA(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), USH1C(15), WT1(32) 10090500 254 148 191 93 48 92 20 49 36 9 0.507 1.000 1.000 242 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), AOX1(15), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), HIBADH(2), HMGCL(1), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), PCCA(17), PCCB(6), SDS(3) 24558262 296 148 270 71 86 48 39 70 52 1 0.00173 1.000 1.000 243 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 39 ACACA(36), ACACB(40), ACAT1(7), ACAT2(9), ACOT12(11), ACSS1(7), ACSS2(10), ACYP1(2), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PCK2(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4) 30926806 348 147 327 115 109 48 47 88 56 0 0.308 1.000 1.000 244 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 38 ABP1(4), ACY3(4), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(10), ASPA(8), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(12), HARS(6), HARS2(8), HDC(14), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), PRPS2(6), UROC1(10), WBSCR22(2) 24926198 279 146 266 90 84 49 37 73 36 0 0.136 1.000 1.000 245 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 40 ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG5(5), ALG6(5), ALG8(13), ALG9(8), B4GALT1(8), B4GALT2(7), B4GALT3(8), DAD1(3), DDOST(4), DHDDS(6), DPM1(3), FUT8(11), GANAB(13), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), RFT1(3), RPN1(4), RPN2(7), ST6GAL1(3), STT3B(11) 27274388 311 146 286 111 82 55 32 87 55 0 0.861 1.000 1.000 246 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 35 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCR(12), BLNK(2), BTK(12), CD19(10), CSK(5), DAG1(10), EPHB2(16), ITPKA(3), ITPKB(15), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PI3(3), PIK3CD(11), PLCG2(28), PPP1R13B(10), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24) 30184815 319 146 297 90 113 54 40 72 39 1 0.0103 1.000 1.000 247 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(5), AKT1(11), AKT2(8), AKT3(8), DAG1(10), GNAQ(11), IKBKG(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PIK3CB(6), PITX2(2), PLD1(19), PLD2(10), PLD3(7), VN1R1(7) 28429292 314 146 306 103 103 60 39 70 41 1 0.187 1.000 1.000 248 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 31 BLNK(2), BTK(12), CALM2(1), CALM3(1), CD79A(6), CD79B(3), ELK1(4), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK14(8), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), RAC1(2), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24) 23999748 282 144 259 92 85 58 31 61 46 1 0.283 1.000 1.000 249 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(4), AGXT(8), AGXT2(9), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), ATP6V0C(1), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CPT1B(14), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), MAOA(7), MAOB(9), PEMT(2), PISD(8), PLCG1(19), PLCG2(28), PSPH(2), SARDH(17), SARS(6), SHMT1(7), SHMT2(5), TARS(10) 26864437 304 144 279 106 117 43 38 57 49 0 0.428 1.000 1.000 250 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 26 ABAT(8), ABP1(4), ACADL(6), ACADM(12), ACADSB(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), MLYCD(4), SDS(3), SMS(4), UPB1(9) 19388375 284 143 264 78 85 40 43 79 37 0 0.00878 1.000 1.000 251 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(8), F12(5), F13B(12), F2(10), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), LPA(30), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10), SERPINF2(4), VWF(36) 24266775 325 143 295 129 81 61 48 83 49 3 0.823 1.000 1.000 252 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 25 DPM2(1), ELK1(4), GNB1(3), GNGT1(1), HRAS(4), IGF1R(22), ITGB1(13), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MYC(5), NGFR(5), PDGFRA(64), PPP2CA(3), PTPRR(16), RPS6KA1(9), RPS6KA5(13), SHC1(14), SOS1(16), SRC(3), STAT3(10) 18254428 243 143 218 92 57 60 34 54 34 4 0.610 1.000 1.000 253 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(35), ATP4B(3), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ATP7A(13), ATP7B(16), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3), PPA2(5), SDHA(14), SDHB(3), SHMT1(7), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1) 26255858 279 143 256 92 87 51 36 59 46 0 0.176 1.000 1.000 254 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 AKT1(11), AKT2(8), AKT3(8), ARHGEF11(24), BCL2(2), CDC42(3), DLG4(10), GNA13(3), IKBKG(2), LPA(30), MAP3K1(21), MAP3K5(16), MAPK8(17), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PI3(3), PIK3CB(6), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RDX(16), ROCK1(35), ROCK2(20), SERPINA4(10), SRF(4) 32302569 363 143 338 112 108 54 33 99 64 5 0.387 1.000 1.000 255 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 AKT1(11), ATF1(6), CDC42(3), CREB1(3), CREB3(6), CREB5(8), DUSP1(7), DUSP10(6), EEF2K(11), ELK1(4), IL1R1(7), MAP2K3(11), MAP2K6(5), MAP3K10(11), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MKNK1(4), MKNK2(7), MYEF2(14), NFKB1(11), NR2C2(11), SRF(4), TRAF6(4) 21860849 265 143 236 73 69 46 40 60 49 1 0.0445 1.000 1.000 256 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 11 CREBBP(81), EP300(56), MAP2K1(12), MAP3K7(9), MAPK3(4), SKIL(9), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26) 12846906 231 143 195 91 67 68 26 36 34 0 0.574 1.000 1.000 257 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 31 ADCY1(27), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(5), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RPS6KA3(16), SYT1(14) 20208502 237 142 216 88 84 57 20 42 34 0 0.407 1.000 1.000 258 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(8), AGXT2(9), AKR1B10(3), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), GNMT(3), HSD3B7(3), MAOA(7), MAOB(9), PEMT(2), PHGDH(3), PIPOX(9), PISD(8), PSAT1(7), PSPH(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SARDH(17), SARS(6), SARS2(4), SDS(3), SHMT1(7), SHMT2(5), TARS(10), TARS2(10) 29237069 303 142 286 109 110 39 39 72 43 0 0.511 1.000 1.000 259 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 AKR1C3(2), ALOX12(4), ALOX12B(6), ALOX15(5), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP2U1(5), CYP4A11(8), CYP4A22(13), CYP4F2(12), CYP4F3(11), DHRS4(1), EPHX2(5), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 26093176 276 142 259 97 92 39 35 74 35 1 0.507 1.000 1.000 260 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 28 ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), DRD1(9), DRD2(9), DRD3(6), DRD5(14), HRH1(4), HRH2(16), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13) 15058320 273 142 250 102 115 44 36 47 31 0 0.154 1.000 1.000 261 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 21 CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PDGFA(2), PDGFRA(64), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10) 19750058 286 142 256 89 70 61 29 74 48 4 0.313 1.000 1.000 262 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(2), CHN1(6), LIMK1(8), MAP3K1(21), MYL2(2), MYLK(33), NCF2(10), PAK1(11), PDGFRA(64), PLD1(19), RAC1(2), RALBP1(8), RPS6KB1(9), TRIO(40), VAV1(24), WASF1(6) 20085355 275 142 257 94 68 59 37 71 36 4 0.296 1.000 1.000 263 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), HRAS(4), MAPK1(3), MAPK3(4), NFKB1(11), NFKBIA(1), PAK1(11), RAC1(2), RB1(139), RELA(10), TFDP1(10) 10258741 234 142 178 89 44 79 21 46 36 8 0.666 1.000 1.000 264 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 30 BTK(12), CALM2(1), CALM3(1), ELK1(4), FCER1A(6), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PAK2(15), PLA2G4A(16), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24) 23763622 293 141 268 86 83 63 32 63 51 1 0.0958 1.000 1.000 265 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(28), GABBR1(20), GPRC5A(5), GPRC5B(4), GPRC5C(10), GPRC5D(3), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM7(36), GRM8(29) 13402320 257 141 223 103 104 34 32 53 34 0 0.630 1.000 1.000 266 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 43 AACS(9), AADAC(7), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ACSM1(10), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH7A1(8), ALDH9A1(4), BDH1(4), BDH2(2), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADH(2), HADHA(12), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), HSD3B7(3), ILVBL(9), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(8), PDHA2(17), PDHB(3), PLA1A(10), PPME1(2), PRDX6(5), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 26488056 298 141 273 99 100 49 37 74 38 0 0.150 1.000 1.000 267 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 28 ACTR2(2), ACTR3(5), ARHGAP1(3), ARHGAP4(7), ARHGAP6(11), ARHGEF1(15), ARHGEF11(24), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), BAIAP2(7), CFL1(2), DIAPH1(7), GSN(4), LIMK1(8), MYL2(2), MYLK(33), OPHN1(11), PIP5K1A(7), PIP5K1B(4), ROCK1(35), SRC(3), TLN1(23), VCL(10) 28260981 252 141 233 89 78 35 27 61 46 5 0.727 1.000 1.000 268 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(6), CHUK(27), ELK1(4), FOS(5), IKBKB(9), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), PPARA(7), RELA(10), TIRAP(5), TLR10(14), TLR2(12), TLR3(15), TLR4(18), TLR6(14), TLR7(18), TLR9(16), TOLLIP(5), TRAF6(4) 24124288 296 141 283 79 76 57 27 86 48 2 0.0458 1.000 1.000 269 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 38 APAF1(27), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), FADD(1), FAS(9), FASLG(3), GZMB(5), IKBKG(2), JUN(2), MAP3K1(21), MAP3K14(6), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), PARP1(17), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(3), TRAF1(7), TRAF2(8) 23512541 266 140 237 83 65 54 32 54 61 0 0.219 1.000 1.000 270 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 37 AARS(10), AARS2(13), CARS(11), CARS2(6), DARS(5), DARS2(8), EARS2(3), EPRS(27), FARS2(7), FARSA(6), FARSB(12), GARS(8), HARS(6), HARS2(8), IARS(10), IARS2(19), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), MTFMT(1), NARS(5), NARS2(11), PARS2(2), QARS(14), RARS(9), SARS(6), SARS2(4), TARS(10), TARS2(10), VARS(7), VARS2(9), WARS(4), WARS2(7), YARS(4), YARS2(7) 35658967 318 140 311 83 103 43 41 83 48 0 0.0391 1.000 1.000 271 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(3), B4GALT1(8), B4GALT2(7), G6PC(5), G6PC2(3), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANC(9), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), HSD3B7(3), LALBA(2), LCT(46), MGAM(26), PFKL(7), PFKM(5), PFKP(16), PGM1(10), PGM3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), UGP2(12) 24841549 283 139 272 100 103 43 31 77 29 0 0.324 1.000 1.000 272 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 38 CDC6(10), CDK2(5), DIAPH2(28), MCM10(12), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), PRIM1(5), RFC1(25), RFC2(3), RFC4(8), RFC5(8), RPA1(12), RPA2(1), RPA4(6), UBA52(3), UBB(3), UBC(7) 32567229 315 138 284 98 67 60 41 86 60 1 0.322 1.000 1.000 273 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 34 CALM2(1), CALM3(1), CAMK1G(7), ELK1(4), FPR1(8), GNA15(6), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NCF1(4), NCF2(10), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PAK1(11), PIK3C2G(21), PLCB1(23), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAC1(2), RELA(10), SYT1(14) 23547750 271 138 256 99 86 46 30 67 41 1 0.550 1.000 1.000 274 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 25 ACVR1(9), ATF2(7), AXIN1(10), BMP10(15), BMP2(9), BMP4(6), BMP5(9), BMP7(15), CHRD(16), FZD1(9), GATA4(4), GSK3B(17), MAP3K7(9), MEF2C(15), MYL2(2), NPPA(1), NPPB(5), RFC1(25), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17) 15907711 260 137 242 83 96 43 28 59 33 1 0.107 1.000 1.000 275 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 18 ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12) 13475126 227 137 205 82 64 62 23 41 35 2 0.378 1.000 1.000 276 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 18 ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12) 13475126 227 137 205 82 64 62 23 41 35 2 0.378 1.000 1.000 277 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 20 ADCY1(27), AKT1(11), ASAH1(4), GNAI1(5), GNB1(3), GNGT1(1), ITGAV(21), ITGB3(16), MAPK1(3), MAPK3(4), PDGFA(2), PDGFRA(64), PLCB1(23), PRKCA(8), PTK2(24), RAC1(2), SMPD1(10), SMPD2(3), SPHK1(3), SRC(3) 16231580 237 137 211 92 58 60 30 59 26 4 0.644 1.000 1.000 278 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ACTG1(6), ACTG2(6), ADCY3(11), ADCY9(22), AK1(2), ARF1(1), ARF4(5), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ERO1L(4), PDIA4(9), PLCG1(19), PLCG2(28), PRKCA(8), SEC61A1(10), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(18) 24099621 270 137 234 97 93 60 30 50 37 0 0.385 1.000 1.000 279 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(8), B4GALT2(7), FBP2(5), G6PC(5), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANAB(13), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), LALBA(2), LCT(46), MGAM(26), PFKM(5), PFKP(16), PGM1(10), PGM3(7) 21134447 248 136 239 93 90 44 27 61 26 0 0.538 1.000 1.000 280 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 34 ACACA(36), ACAT1(7), ACAT2(9), ACYP1(2), ADH5(7), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4) 23890658 289 136 267 101 89 46 37 74 43 0 0.463 1.000 1.000 281 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 25 AKT1(11), AKT2(8), AKT3(8), ANKRD6(12), AXIN1(10), AXIN2(27), CER1(6), CSNK1A1(3), DACT1(19), DKK1(9), DKK3(9), DKK4(8), FSTL1(10), GSK3A(6), GSK3B(17), LRP1(53), MVP(10), NKD1(6), PIN1(2), PSEN1(4), PTPRA(6), SENP2(4), SFRP1(3), TSHB(2), WIF1(5) 20523244 258 136 242 82 92 37 29 50 47 3 0.238 1.000 1.000 282 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(3), CREBBP(81), EP300(56), NCOA3(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RARA(6), RXRA(8) 14144361 213 135 187 87 52 56 28 41 36 0 0.754 1.000 1.000 283 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(10), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(8), ADSSL1(6), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), ASRGL1(1), ASS1(5), CAD(23), CRAT(11), DARS(5), DARS2(8), DDO(6), DLAT(10), DLD(4), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), NARS2(11), PC(16), PDHA1(8), PDHA2(17), PDHB(3) 25476532 280 135 263 109 96 39 41 64 40 0 0.747 1.000 1.000 284 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(12), ALAS2(12), BLVRA(2), BLVRB(2), COX10(6), COX15(8), CP(24), CPOX(4), EARS2(3), EPRS(27), FECH(4), FTH1(1), FTMT(8), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), MMAB(2), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UROD(3), UROS(5) 28229195 298 135 269 72 67 55 39 80 57 0 0.0271 1.000 1.000 285 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 30 AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ATP6V0C(1), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADHA(12), PLOD1(8), PLOD2(10), PLOD3(7), SDS(3), SHMT1(7), SHMT2(5), TMLHE(6) 23099018 267 135 244 70 79 46 36 63 43 0 0.00585 1.000 1.000 286 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(27), CREBBP(81), EP300(56), FADD(1), HDAC3(3), IKBKB(9), IKBKG(2), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 15327977 219 135 188 81 59 66 23 36 35 0 0.463 1.000 1.000 287 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 22 ATF2(7), BCR(12), BLNK(2), ELK1(4), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8IP3(12), PAPPA(39), RAC1(2), RPS6KA1(9), RPS6KA3(16), SHC1(14), SOS1(16), SYK(8), VAV1(24), VAV3(30) 19547987 259 134 238 64 78 49 33 65 33 1 0.00470 1.000 1.000 288 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), PON1(12) 19550871 255 133 246 77 98 42 22 63 28 2 0.0872 1.000 1.000 289 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 35 ATF2(7), CDC42(3), CREB1(3), DAXX(18), DDIT3(5), ELK1(4), HRAS(4), HSPB2(3), MAP2K6(5), MAP3K1(21), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MYC(5), PLA2G4A(16), RAC1(2), RIPK1(7), RPS6KA5(13), SHC1(14), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8) 23900243 279 133 257 87 84 58 28 62 46 1 0.276 1.000 1.000 290 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 24 ABAT(8), ABP1(4), ACADM(12), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HIBCH(3), MLYCD(4), SMS(4), SRM(1), UPB1(9) 17831348 251 132 232 76 74 35 39 69 34 0 0.0736 1.000 1.000 291 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 17 CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IL6(7), IL6R(8), IL6ST(15), JAK1(22), JAK3(31), JUN(2), MAP2K1(12), MAPK3(4), PTPN11(41), SHC1(14), SOS1(16), SRF(4), STAT3(10) 13222852 206 132 161 61 47 54 27 42 34 2 0.184 1.000 1.000 292 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(5), CDKN1B(6), CKS1B(2), CUL1(17), NEDD8(1), RB1(139), RBX1(1), SKP2(3), TFDP1(10), UBE2M(2) 6024134 192 132 139 73 31 70 10 38 35 8 0.660 1.000 1.000 293 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 29 ABAT(8), ACACA(36), ACADL(6), ACADM(12), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SDS(3), SUCLA2(9), SUCLG1(3), SUCLG2(1) 22237433 275 132 253 61 84 36 40 66 49 0 0.00176 1.000 1.000 294 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(18), CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), SKP2(3), TFDP1(10) 6148005 200 132 145 78 34 73 10 44 31 8 0.619 1.000 1.000 295 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(27), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), GAS2(4), LMNA(1), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), SPTAN1(30), TNFRSF10A(8), TNFRSF10B(8), TNFRSF25(2), TNFSF10(3), TNFSF12(2), TRAF2(8) 22591935 240 131 209 79 57 52 27 54 49 1 0.485 1.000 1.000 296 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(8), ARG1(2), ARG2(6), ASL(5), ASS1(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), EPRS(27), GAMT(6), GATM(2), GLUD1(4), GLUD2(22), GOT1(7), GOT2(2), LAP3(4), NOS1(31), NOS3(23), OAT(4), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(2), PRODH(5), RARS(9) 23050422 269 131 249 85 89 38 38 64 40 0 0.220 1.000 1.000 297 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CYP2C19(12), CYP2C9(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), HADHA(12), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3) 20365936 269 131 240 81 69 55 35 67 42 1 0.165 1.000 1.000 298 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), NOS1(31), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), SYT1(14) 16989570 238 131 222 100 85 43 22 51 36 1 0.781 1.000 1.000 299 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 29 AGT(12), AGTR1(14), ATF2(7), CALM2(1), CALM3(1), ELK1(4), GNAQ(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), MEF2A(7), MEF2C(15), MEF2D(3), PAK1(11), PRKCA(8), PTK2(24), PTK2B(13), RAC1(2), SHC1(14), SOS1(16), SRC(3), SYT1(14) 19590708 246 130 228 83 51 52 24 71 47 1 0.578 1.000 1.000 300 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 27 ATF1(6), BAD(1), CREB1(3), CREB3(6), CREB5(8), DUSP4(6), DUSP6(7), DUSP9(9), EEF2K(11), MAP2K1(12), MAP2K2(3), MAP3K8(4), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MOS(10), NFKB1(11), RAP1A(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), SHC1(14), SOS1(16), SOS2(17), TRAF3(12) 18988327 226 130 209 71 63 46 30 45 41 1 0.162 1.000 1.000 301 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(8), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), GMPS(16), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSS(9), NADSYN1(4), PPAT(8), QARS(14) 22869210 250 129 228 64 65 53 31 70 31 0 0.0209 1.000 1.000 302 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 17 CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), INSR(21), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PTPN11(41), RASA1(24), SHC1(14), SLC2A4(8), SOS1(16), SRF(4) 13163001 204 129 174 67 49 49 25 49 31 1 0.331 1.000 1.000 303 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 18 AXIN1(10), BTRC(11), CCND1(2), CREBBP(81), CSNK1A1(3), CSNK1D(15), CSNK2A1(7), CTBP1(5), FZD1(9), GSK3B(17), HDAC1(5), MAP3K7(9), MYC(5), NLK(12), PPARD(5), PPP2CA(3), TLE1(7), WIF1(5) 13429103 211 129 191 80 57 47 35 38 33 1 0.461 1.000 1.000 304 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(15), POLA2(6), POLB(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLG(9), POLG2(4), POLH(16), POLK(11), POLL(2), POLM(12), POLQ(42), PRIM1(5), PRIM2(3), REV1(16), REV3L(45), RFC5(8) 27921628 285 128 260 87 65 42 38 81 57 2 0.457 1.000 1.000 305 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 16 CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IGF1(6), IGF1R(22), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PTPN11(41), RASA1(24), SHC1(14), SOS1(16), SRF(4) 12683249 203 128 172 65 50 49 22 47 34 1 0.297 1.000 1.000 306 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 21 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), GSK3A(6), GSK3B(17), IL4R(6), IRS1(21), JAK1(22), JAK3(31), MAP4K1(7), MAPK1(3), MAPK3(4), PDK1(7), PIK3CD(11), PPP1R13B(10), SHC1(14), SOS1(16), SOS2(17), STAT6(4) 19545551 226 128 200 63 62 48 22 48 44 2 0.134 1.000 1.000 307 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 36 ACAA1(7), ACAA2(4), ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1B10(3), AKR1D1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), HSD3B7(3), LIPA(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SLC27A5(9), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2) 20508223 237 127 222 71 61 42 36 66 31 1 0.0977 1.000 1.000 308 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 41 ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GAPDHS(3), GCK(6), GOT1(7), GOT2(2), GPI(6), HK1(13), HK2(7), HK3(22), LDHAL6B(7), LDHB(8), LDHC(4), MDH1(8), MDH2(3), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PKLR(12), PKM2(4), TNFAIP1(4), TPI1(3) 27107720 265 126 248 118 110 35 25 60 35 0 0.936 1.000 1.000 309 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 24 AKT1(11), CABIN1(24), CALM2(1), CALM3(1), CAMK1G(7), HDAC5(14), IGF1(6), IGF1R(22), INSR(21), MAP2K6(5), MAPK14(8), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYT1(14), YWHAH(5) 18427639 205 126 193 89 65 46 23 43 28 0 0.834 1.000 1.000 310 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(4), ACY1(6), ADC(3), AGMAT(7), ALDH18A1(8), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), ASS1(5), CPS1(39), GATM(2), MAOA(7), MAOB(9), NAGS(6), ODC1(8), OTC(17), SAT1(5), SAT2(2), SMS(4), SRM(1) 19619750 232 126 210 70 71 43 29 58 31 0 0.111 1.000 1.000 311 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CALM2(1), CALM3(1), CHUK(27), EGR2(16), EGR3(6), GNAQ(11), MAP3K1(21), MYC(5), NFATC2(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), SYT1(14), VIP(3), VIPR2(11) 17855655 227 126 205 73 70 50 24 44 39 0 0.182 1.000 1.000 312 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(15), AGT(12), AGTR1(14), AGTR2(17), CMA1(1), COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), REN(10) 18109524 216 125 205 72 54 30 29 60 43 0 0.100 1.000 1.000 313 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(12), CALCRL(9), CD97(12), CRHR1(6), CRHR2(6), ELTD1(14), EMR1(17), EMR2(11), GHRHR(2), GIPR(1), GLP1R(11), GLP2R(10), GPR64(19), LPHN1(20), LPHN2(30), LPHN3(30), SCTR(6), VIPR1(7), VIPR2(11) 18379554 239 125 235 99 79 37 20 74 29 0 0.764 1.000 1.000 314 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(81), EP300(56), LPL(12), NCOA1(15), NCOA2(23), PPARG(4), RXRA(8) 12259823 199 125 178 83 50 56 28 37 28 0 0.735 1.000 1.000 315 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(5), NFYB(2), NFYC(10), RB1(139), SP1(7), SP3(13) 4757427 176 125 123 59 23 74 10 37 24 8 0.121 1.000 1.000 316 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), P4HB(6), SLC23A1(10), SLC23A2(18), SLC2A1(7), SLC2A3(13) 17893323 201 125 188 77 52 26 31 51 41 0 0.268 1.000 1.000 317 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 26 AACS(9), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(8), PDHA2(17), PDHB(3), SDHB(3), SDS(3) 17310938 230 124 208 67 70 39 32 59 30 0 0.0391 1.000 1.000 318 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TAT(16), TPO(36) 14444897 203 124 177 62 84 28 25 38 28 0 0.0672 1.000 1.000 319 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 23 AKT1(11), AKT2(8), AKT3(8), CISH(2), IARS(10), IL13RA1(6), IL2RG(9), IL4(5), IL4R(6), INPP5D(10), JAK1(22), JAK3(31), PI3(3), PPP1R13B(10), RPS6KB1(9), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT6(4), TYK2(5) 21234277 219 124 195 62 56 40 23 51 47 2 0.218 1.000 1.000 320 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), TFDP1(10) 4739779 179 123 126 66 28 68 9 37 29 8 0.497 1.000 1.000 321 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 28 B4GALT5(5), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GCNT1(9), GCNT3(6), GCNT4(14), OGT(10), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(6) 21606286 249 123 238 96 76 40 34 66 33 0 0.857 1.000 1.000 322 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(25), C5(25), C6(27), C7(11), ICAM1(4), IL1A(1), IL6(7), IL8(6), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELP(15), TNF(2), VCAM1(15) 16334425 210 123 200 73 69 29 21 50 40 1 0.343 1.000 1.000 323 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), DAG1(10), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFAT5(6), PDE6A(14), PDE6B(11), PDE6C(12), PDE6D(2), SLC6A13(10), TF(21) 23328549 267 123 265 89 83 48 29 61 45 1 0.193 1.000 1.000 324 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(7), ACAT2(9), ACOT11(9), ACYP1(2), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), FN3K(1), GCDH(8), HADHA(12), ITGB1BP3(1), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3) 17500620 214 122 190 71 53 43 28 51 38 1 0.407 1.000 1.000 325 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(27), IFNA1(8), IFNB1(6), IKBKB(9), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL1RN(7), IL6(7), IRAK1(6), IRAK2(11), IRAK3(11), JUN(2), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2), TOLLIP(5), TRAF6(4) 19825512 242 122 224 68 76 43 25 64 34 0 0.0748 1.000 1.000 326 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 18 DIAPH1(7), FYN(17), GSN(4), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PTK2(24), PXN(2), ROCK1(35), SHC1(14), SRC(3), TLN1(23) 20592296 212 121 186 76 51 30 31 49 45 6 0.728 1.000 1.000 327 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(14), ACE2(15), AGT(12), AGTR1(14), AGTR2(17), ANPEP(19), CMA1(1), CPA3(5), CTSA(6), CTSG(5), ENPEP(24), LNPEP(23), MAS1(3), MME(27), NLN(13), REN(10), THOP1(6) 14399905 214 121 194 54 52 38 26 60 38 0 0.0172 1.000 1.000 328 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(81), EP300(56), ESR1(21), MAPK1(3), MAPK3(4), PELP1(11), SRC(3) 10143037 179 121 157 75 46 47 21 34 31 0 0.809 1.000 1.000 329 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 AKR1C3(2), ALOX12(4), ALOX15(5), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(11), EPX(14), LPO(10), LTA4H(2), MPO(17), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13), TPO(36) 18151964 216 121 203 73 93 28 26 42 27 0 0.212 1.000 1.000 330 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 27 DUSP1(7), GORASP1(13), IKBKG(2), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK5(7), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CD(11), SYT1(14), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4) 16320083 210 120 187 65 64 50 21 45 30 0 0.137 1.000 1.000 331 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 21 ABP1(4), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), AOC2(12), AOC3(10), ASPA(8), CNDP1(7), DDC(5), HAL(12), HARS(6), HDC(14), HNMT(11), MAOA(7), MAOB(9), PRPS2(6) 15370669 200 119 185 53 63 34 26 55 22 0 0.0148 1.000 1.000 332 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 20 CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IL2(5), IL2RA(6), IL2RB(5), IL2RG(9), JAK1(22), JAK3(31), JUN(2), LCK(9), MAP2K1(12), MAPK3(4), MAPK8(17), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8) 14560350 210 119 179 56 49 44 21 44 50 2 0.188 1.000 1.000 333 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 25 ACAA1(7), ACAA2(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AKR1D1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), SOAT2(4), SRD5A1(2), SRD5A2(2) 14865733 199 118 185 49 49 38 29 55 27 1 0.00984 1.000 1.000 334 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 37 ARNTL(14), AZIN1(3), BTG1(2), CBX3(7), CRY1(17), CRY2(5), DNAJA1(5), EIF4G2(16), ETV6(11), GFRA1(17), GSTM3(6), GSTP1(1), HERPUD1(3), HSPA8(13), IDI1(4), KLF9(1), MYF6(7), NCKAP1(17), NCOA4(9), NR1D2(10), PER1(13), PER2(9), PIGF(1), PPP1R3C(6), PPP2CB(4), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(8), TUBB3(10), UCP3(3), UGP2(12), VAPA(2), ZFR(21) 23709984 262 118 232 75 75 40 23 76 46 2 0.216 1.000 1.000 335 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(14), EPHA4(26), EPHB1(38), FYN(17), ITGA1(12), ITGB1(13), L1CAM(17), LYN(13), RAP1B(2), SELP(15) 10545769 167 118 153 56 52 34 31 31 18 1 0.135 1.000 1.000 336 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(12), ACO1(12), ACO2(7), CLYBL(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), OGDHL(16), PC(16), PCK1(6), PCK2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1) 19904306 187 118 175 68 61 25 27 49 25 0 0.506 1.000 1.000 337 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(6), AKR1B10(3), ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), FUK(9), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), HSD3B7(3), KHK(4), LHPP(6), MPI(4), MTMR1(13), MTMR2(8), MTMR6(11), PFKFB1(14), PFKFB2(5), PFKFB3(3), PFKFB4(5), PFKL(7), PFKM(5), PFKP(16), PGM2(4), PHPT1(2), PMM1(5), PMM2(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SORD(2), TPI1(3), TSTA3(1) 24455756 236 118 222 93 95 31 25 54 31 0 0.680 1.000 1.000 338 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(6), SGMS2(8), SGPP1(8), SGPP2(6), SMPD1(10), SMPD2(3), SMPD3(4), SMPD4(9), SPHK1(3), SPHK2(5), SPTLC1(12), SPTLC2(9), UGCG(9), UGT8(12) 21682977 235 118 223 87 72 41 34 53 34 1 0.443 1.000 1.000 339 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 25 BCAR1(6), CALM2(1), CALM3(1), CRKL(5), GNAQ(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), PAK1(11), PLCG1(19), PRKCA(8), PTK2B(13), RAC1(2), SHC1(14), SOS1(16), SRC(3), SYT1(14) 17281963 209 118 190 77 46 44 22 63 33 1 0.821 1.000 1.000 340 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6) 16773466 208 117 185 76 44 50 26 57 30 1 0.632 1.000 1.000 341 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 26 AGA(7), ARSB(10), FUCA1(7), FUCA2(5), GALNS(6), GBA(4), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NAGLU(6), NEU1(6), NEU2(6), NEU3(2), SPAM1(13) 21117860 237 116 219 83 77 52 22 57 29 0 0.374 1.000 1.000 342 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 20 CSNK2A1(7), EGF(8), ELK1(4), FOS(5), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10) 19727722 228 115 208 68 63 40 23 57 43 2 0.328 1.000 1.000 343 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), BTRC(11), CDC16(6), CDC20(3), CDC23(12), CDC26(1), CDC27(21), CUL1(17), CUL2(15), CUL3(8), FBXW11(13), FZR1(4), ITCH(7), RBX1(1), SKP1(2), SKP2(3), SMURF1(9), SMURF2(7), TCEB1(1), TCEB2(1), UBA1(10), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(4), UBE2E2(4), UBE2E3(1), WWP1(21), WWP2(9) 26788878 242 115 226 84 73 34 32 61 40 2 0.570 1.000 1.000 344 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(11), ADRBK2(11), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CLCA1(14), CLCA2(11), CLCA4(15), CNGA3(17), CNGA4(14), CNGB1(15), GNAL(5), GUCA1A(3), GUCA1B(4), GUCA1C(3), PDC(4), PDE1C(19), PRKACA(2), PRKACB(5), PRKACG(9), PRKG1(18), PRKG2(12), PRKX(3) 21422132 228 115 218 107 64 34 31 64 35 0 0.978 1.000 1.000 345 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 27 AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CFLAR(3), CRKL(5), FOS(5), HRAS(4), IL2RA(6), IL2RB(5), IL2RG(9), IRS1(21), JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), MYC(5), NMI(4), PPIA(1), PTPN6(4), RPS6KB1(9), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8) 18470104 224 115 190 66 54 37 31 43 57 2 0.341 1.000 1.000 346 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(2), DLAT(10), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), PC(16), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PDK1(7), PDK2(9), PDK3(6), PDK4(6), PDP2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1) 19541091 203 115 186 81 64 33 26 51 29 0 0.761 1.000 1.000 347 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(14), CAPN1(2), CAPN2(10), CAPNS1(4), CAPNS2(4), CXCR3(5), EGF(8), HRAS(4), ITGA1(12), ITGB1(13), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTK2(24), PXN(2), TLN1(23) 20833582 202 115 196 79 54 43 33 42 29 1 0.605 1.000 1.000 348 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(27), FADD(1), IKBKB(9), IKBKG(2), IL1A(1), IL1R1(7), IRAK1(6), MAP3K1(21), MAP3K14(6), MAP3K7(9), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TLR4(18), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 16109182 193 115 178 62 46 55 18 44 30 0 0.253 1.000 1.000 349 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), LTA(1), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNFAIP3(42), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12) 15452709 195 115 173 64 52 55 20 34 34 0 0.206 1.000 1.000 350 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(5), CSF1R(16), DDX20(7), E2F4(2), ETS1(10), ETS2(5), ETV3(5), FOS(5), HDAC2(8), HDAC5(14), HRAS(4), JUN(2), NCOR2(44), RBL1(21), RBL2(24), SIN3A(28), SIN3B(10) 17145408 210 114 183 80 55 41 20 42 52 0 0.872 1.000 1.000 351 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(24), CALM2(1), CALM3(1), CAPN2(10), CAPNS1(4), CAPNS2(4), EP300(56), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SYT1(14) 15300958 173 114 153 73 50 35 22 32 34 0 0.825 1.000 1.000 352 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(7), CDK7(3), ERCC3(19), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F2(1), GTF2H1(6), GTF2H4(3), ILK(3), MNAT1(4), POLR1A(15), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3B(14), POLR3D(5), POLR3E(13), POLR3H(2), POLR3K(2), TAF12(4), TAF13(3), TAF5(13), TAF6(9), TAF7(3), TAF9(3), TBP(2) 23929971 205 114 194 77 53 36 28 49 39 0 0.782 1.000 1.000 353 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 25 BIRC2(7), BIRC3(18), CASP3(4), CASP8(20), CFLAR(3), FADD(1), IKBKG(2), JUN(2), MAP3K3(8), MAP3K7(9), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NR2C2(11), RALBP1(8), RIPK1(7), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 16227029 185 114 163 61 43 51 16 37 38 0 0.397 1.000 1.000 354 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(10), ABAT(8), ADSL(13), ADSS(8), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), CAD(23), CRAT(11), DARS(5), DDO(6), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), PC(16) 17503229 190 112 176 73 64 24 30 47 25 0 0.674 1.000 1.000 355 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(10), DYRK1B(14), GLI2(28), GLI3(44), GSK3B(17), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SHH(3), SMO(13), SUFU(5) 10475187 169 112 154 71 60 38 14 30 27 0 0.691 1.000 1.000 356 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(13), ITGB3(16), PTK2(24), PXN(2), RAC1(2), SPTAN1(30), SRC(3), TLN1(23) 19208856 187 111 180 96 60 31 23 45 26 2 0.997 1.000 1.000 357 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C8B(23), C9(12), MASP1(23) 16668527 202 110 192 65 59 26 22 52 41 2 0.515 1.000 1.000 358 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 19 GH1(5), GHR(12), HRAS(4), INSR(21), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), PLCG1(19), PRKCA(8), PTPN6(4), RPS6KA1(9), SHC1(14), SLC2A4(8), SOS1(16), SRF(4), STAT5A(10), STAT5B(20) 16763437 194 110 172 79 56 31 27 44 35 1 0.929 1.000 1.000 359 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(75), MAP2(60), PPP1CA(2), PPP2CA(3), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6), PRKCE(6) 12641543 175 109 151 56 36 40 23 39 37 0 0.395 1.000 1.000 360 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 22 ADCY1(27), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), HRAS(4), MAPK1(3), MAPK14(8), MAPK3(4), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAC1(2), RPS6KA1(9), RPS6KA5(13), SOS1(16) 15628224 170 109 161 60 57 39 19 35 20 0 0.297 1.000 1.000 361 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(11), CHIT1(12), CMAS(9), CTBS(6), CYB5R1(4), CYB5R3(2), GFPT1(6), GFPT2(12), GNE(8), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NAGK(7), NANS(2), NPL(4), PGM3(7), PHPT1(2), RENBP(3), UAP1(6) 19707803 200 109 191 56 74 36 24 38 28 0 0.0434 1.000 1.000 362 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(12), BAIAP2(7), CASP1(6), CASP3(4), CASP7(3), CASP8(20), GAPDH(2), INSR(21), ITCH(7), MAGI1(31), MAGI2(32), RERE(15), WWP1(21), WWP2(9) 16031074 190 109 176 70 53 31 28 38 39 1 0.659 1.000 1.000 363 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 19 BTK(12), DLG4(10), EPHB2(16), F2(10), F2RL2(8), JUN(2), MAP2K5(6), MAPK1(3), MAPK7(6), MAPK8(17), MYEF2(14), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RASAL1(9), SRC(3), TEC(10), VAV1(24) 17214330 210 109 205 78 69 42 25 50 24 0 0.621 1.000 1.000 364 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(16), FYN(17), LRP8(5), RELN(95), VLDLR(15) 9756132 156 107 129 50 41 38 17 39 21 0 0.116 1.000 1.000 365 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(27), ARHGDIB(5), BIRC2(7), BIRC3(18), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), GZMB(5), LMNA(1), LMNB1(11), LMNB2(3), PRF1(8) 13214043 162 106 135 55 30 36 14 44 38 0 0.763 1.000 1.000 366 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TNFAIP3(42), TRAF3(12), TRAF6(4) 12705040 167 106 149 51 41 47 16 32 31 0 0.193 1.000 1.000 367 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 19 F2(10), F2R(11), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), PLA2G4A(16), PLCB1(23), PRKCA(8), PTGS1(10), PTK2(24), SRC(3), SYK(8), TBXAS1(13) 15953581 183 106 169 81 59 39 24 40 21 0 0.916 1.000 1.000 368 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 23 ATF1(6), CASP2(8), CHUK(27), CRADD(4), IKBKB(9), IKBKG(2), JUN(2), LTA(1), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP4K2(6), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNF(2), TNFRSF1A(4), TRAF2(8) 15496295 184 106 168 63 53 43 19 42 27 0 0.375 1.000 1.000 369 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(10), CARS(11), DARS(5), EPRS(27), FARS2(7), GARS(8), HARS(6), IARS(10), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), NARS(5), QARS(14), RARS(9), SARS(6), TARS(10), WARS(4), WARS2(7), YARS(4) 22744531 192 105 186 44 58 26 28 52 28 0 0.0199 1.000 1.000 370 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1D1(9), ARSB(10), ARSD(9), ARSE(4), CYP11B1(17), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10) 18133225 189 105 176 53 66 24 23 36 40 0 0.0359 1.000 1.000 371 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 18 CCL11(2), CCR3(11), CFL1(2), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), LIMK1(8), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), NOX1(4), PIK3C2G(21), PLCB1(23), PRKCA(8), PTK2(24), ROCK2(20) 13433656 163 105 154 62 42 32 16 44 28 1 0.775 1.000 1.000 372 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 15 ADCY1(27), ARHGEF1(15), F2(10), F2R(11), GNA12(7), GNA13(3), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), MAP3K7(9), PLCB1(23), PRKCA(8), PTK2B(13), ROCK1(35) 13450290 181 105 162 72 55 35 11 44 32 4 0.935 1.000 1.000 373 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12), MASP1(23), MASP2(10), MBL2(3) 17012866 192 104 183 67 54 22 21 51 42 2 0.740 1.000 1.000 374 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 BCAR1(6), CXCL12(2), CXCR4(7), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), NFKB1(11), PIK3C2G(21), PLCG1(19), PRKCA(8), PTK2(24), PTK2B(13), PXN(2), RELA(10) 14649963 166 104 158 75 46 35 20 38 26 1 0.957 1.000 1.000 375 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(2), BLVRB(2), CP(24), CPOX(4), EPRS(27), FECH(4), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UROD(3), UROS(5) 18782028 175 104 156 46 43 30 23 40 39 0 0.187 1.000 1.000 376 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 17 CSNK2A1(7), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), MPL(9), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), THPO(6) 15324373 187 104 164 54 47 31 18 44 46 1 0.488 1.000 1.000 377 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 17 ADCY1(27), AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(22), IL3(6), KITLG(3), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), YWHAH(5) 9978503 132 103 121 48 52 31 7 25 17 0 0.406 1.000 1.000 378 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 11 ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), CSK(5), CTNNA1(28), CTNNA2(38), PTK2(24), PXN(2), SRC(3), VCL(10) 11167961 154 103 145 58 57 21 17 37 21 1 0.497 1.000 1.000 379 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 33 ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), GSR(5), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), TXNDC12(3) 12483769 167 103 148 41 36 33 24 51 23 0 0.0148 1.000 1.000 380 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(14), ADCY1(27), CAP1(5), CCNB1(8), CDC25C(6), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), MAPK1(3), MAPK3(4), MYT1(25), PIN1(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KA1(9), SRC(3) 12320017 154 102 147 49 61 29 20 31 13 0 0.0646 1.000 1.000 381 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 16 CALM2(1), CALM3(1), CDKN1A(2), GNAQ(11), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SP1(7), SP3(13), SYT1(14) 13023936 138 101 124 59 43 33 13 25 24 0 0.839 1.000 1.000 382 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(17), AGT(12), AGTR2(17), EDN1(3), EDNRA(9), EDNRB(19), EGF(8), FOS(5), HRAS(4), JUN(2), MYC(5), NFKB1(11), PLCG1(19), PRKCA(8), RELA(10) 12325333 149 101 133 56 42 24 24 32 27 0 0.690 1.000 1.000 383 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(8), AMD1(4), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTAP(3), MTFMT(1), MTR(14), SRM(1), TAT(16) 14116545 174 101 161 57 66 21 26 33 27 1 0.248 1.000 1.000 384 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AADAC(7), ABP1(4), AOC2(12), AOC3(10), CES1(14), CES7(1), ESCO1(22), ESCO2(18), LIPA(3), MYST3(34), MYST4(33), NAT6(2), PLA1A(10), PNPLA3(6), PPME1(2), PRDX6(5), SH3GLB1(6) 16351661 189 101 172 72 50 35 24 49 30 1 0.702 1.000 1.000 385 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 21 ASAH1(4), CAMP(1), CASP3(4), CERK(3), CREB1(3), CREB3(6), CREB5(8), DAG1(10), EPHB2(16), FOS(5), GNAQ(11), ITPKA(3), ITPKB(15), JUN(2), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13) 12693711 160 101 153 51 43 32 17 40 28 0 0.188 1.000 1.000 386 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(44), APOA1(3), APOA4(6), APOC1(1), APOC2(2), APOE(1), CETP(12), CYP7A1(14), DGAT1(5), HMGCR(7), LCAT(4), LDLR(11), LIPC(6), LPL(12), LRP1(53), SCARB1(4), SOAT1(6) 18004821 191 101 181 71 65 30 25 48 23 0 0.546 1.000 1.000 387 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), HAL(12) 14785991 161 100 152 58 50 29 19 38 25 0 0.631 1.000 1.000 388 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(15), DRD1(9), DRD2(9), GRM1(37), PLCB1(23), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 10797443 147 99 133 54 50 35 7 33 22 0 0.565 1.000 1.000 389 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(16), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPHN(18), NSF(4), SRC(3), UBQLN1(6) 8469740 155 99 140 47 40 22 17 51 25 0 0.205 1.000 1.000 390 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(19), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC3(3), NCOA1(15), NCOA2(23), NCOA3(21), NCOR2(44), POLR2A(14), RARA(6), RXRA(8), TBP(2) 15709380 181 99 163 83 52 29 29 36 35 0 0.988 1.000 1.000 391 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(12), EEA1(19), GRASP(3), GSK3A(6), GSK3B(17), LYN(13), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PLCG1(19), PRKCE(6), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(9) 15395130 170 98 159 57 53 35 23 29 29 1 0.370 1.000 1.000 392 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(27), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP7(3), CASP8(20), CASP9(6), DFFA(6), DFFB(2), GZMB(5), PRF1(8), SCAP(9), SREBF1(8), SREBF2(10) 11809219 140 98 120 47 28 25 16 38 33 0 0.596 1.000 1.000 393 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(12), ACO2(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), PC(16), PCK1(6), SDHA(14), SDHB(3), SUCLA2(9), SUCLG1(3), SUCLG2(1) 13467799 128 96 119 52 38 19 18 34 19 0 0.745 1.000 1.000 394 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 20 AKT1(11), AXIN1(10), CCND1(2), CD14(6), FZD1(9), GJA1(9), GNAI1(5), GSK3B(17), IRAK1(6), LBP(8), LEF1(9), LY96(4), MYD88(4), NFKB1(11), PDPK1(4), PPP2CA(3), RELA(10), TIRAP(5), TLR4(18), TOLLIP(5) 11383867 156 96 149 48 51 37 22 23 22 1 0.0712 1.000 1.000 395 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(5), ALOX5(12), CYP1A2(11), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), HSD3B7(3), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 16709635 177 96 169 62 62 35 18 48 13 1 0.325 1.000 1.000 396 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR7(7), CD28(5), CD4(4), CXCR3(5), CXCR4(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18R1(16), IL2(5), IL4(5), IL4R(6), TGFB1(2), TGFB2(10), TGFB3(2) 14143712 159 96 145 62 34 37 21 45 21 1 0.641 1.000 1.000 397 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(7), CREBBP(81), DFFA(6), DFFB(2), GZMA(11), GZMB(5), HMGB2(2), NME1(1), PRF1(8), SET(6) 7165757 130 96 119 51 34 31 14 31 20 0 0.666 1.000 1.000 398 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(7), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GCNT2(26), ST3GAL6(16), ST8SIA1(10) 9215862 142 95 131 33 48 20 11 41 21 1 0.0228 1.000 1.000 399 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 16 CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PLCG1(19), PTPN6(4), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20) 11764340 141 94 124 47 38 23 14 32 33 1 0.762 1.000 1.000 400 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(10), SMPD2(3), SPTLC1(12), SPTLC2(9), UGCG(9) 15097703 165 94 155 62 50 30 22 43 20 0 0.538 1.000 1.000 401 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), XYLB(6) 17778277 187 94 169 46 33 30 23 55 46 0 0.143 1.000 1.000 402 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 26 ATG3(4), ATG7(1), BECN1(3), GABARAPL1(1), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(29), PIK3R4(21), PRKAA1(9), PRKAA2(20), ULK2(14), ULK3(3) 12938288 156 94 140 48 26 36 22 49 22 1 0.348 1.000 1.000 403 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(4), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(7), EDN1(3), EDNRA(9), EDNRB(19), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(16), PRL(4), PTGDR(9), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 14267644 160 93 151 58 59 18 14 46 23 0 0.566 1.000 1.000 404 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(11), F13A1(15), F2(10), F2R(11), FGA(23), FGB(6), FGG(7), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10) 9577865 148 92 137 52 41 26 25 33 23 0 0.490 1.000 1.000 405 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 AKR1B1(6), ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), GCK(6), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), KHK(4), MPI(4), PFKFB1(14), PFKFB3(3), PFKFB4(5), PFKM(5), PFKP(16), PMM1(5), PMM2(2), SORD(2), TPI1(3) 15803791 154 92 145 59 62 19 15 38 20 0 0.581 1.000 1.000 406 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(8), CARM1(3), CBS(4), CTH(6), HEMK1(1), LCMT1(1), LCMT2(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), METTL2B(3), METTL6(8), PAPSS1(5), PAPSS2(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SCLY(12), SEPHS1(7), SEPHS2(5), WBSCR22(2) 15946771 156 92 152 51 42 27 22 41 24 0 0.240 1.000 1.000 407 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), GLCE(8), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), NDST1(10), NDST2(10), NDST3(19), NDST4(13) 13840841 152 92 147 57 58 29 13 34 18 0 0.646 1.000 1.000 408 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 18 CCR5(11), CD3D(5), CD3E(2), CXCR3(5), ETV5(15), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), JUN(2), MAP2K6(5), MAPK14(8), MAPK8(17), STAT4(13), TYK2(5) 10996527 138 91 126 53 25 34 21 41 17 0 0.724 1.000 1.000 409 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 21 CALM2(1), CALM3(1), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), HDAC5(14), MEF2A(7), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(5), PPP3CB(11), PPP3CC(7), SLC2A4(8), SYT1(14), YWHAH(5) 12803247 141 91 135 67 43 31 11 30 26 0 0.958 1.000 1.000 410 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 AANAT(2), ACHE(5), CHAT(17), DBH(9), DDC(5), GAD1(17), GAD2(15), HDC(14), MAOA(7), PAH(17), PNMT(3), SLC18A3(12), TPH1(4) 9026307 127 90 119 54 42 19 12 44 10 0 0.746 1.000 1.000 411 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 16 AKT1(11), BCL2(2), BCR(12), CRKL(5), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), MYC(5), SOS1(16), STAT1(17), STAT5A(10), STAT5B(20) 12475121 163 90 152 41 46 27 21 41 28 0 0.0396 1.000 1.000 412 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(4), GLB1(9), HEXA(4), HEXB(5), LCT(46), SLC33A1(10), ST3GAL1(3), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10) 10634557 138 90 123 52 50 33 13 31 11 0 0.491 1.000 1.000 413 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(7), CHUK(27), IFNG(3), IKBKB(9), IL2(5), IL4(5), JUN(2), MAP3K1(21), MAP3K5(16), MAP4K5(4), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), TNFRSF9(10), TRAF2(8) 13368999 164 89 147 40 44 41 16 44 19 0 0.0246 1.000 1.000 414 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 8 CSF1R(16), EGF(8), PDGFRA(64), PRKCA(8), SH3GLB1(6), SH3GLB2(6), SH3KBP1(8), SRC(3) 8407613 119 89 108 56 18 36 17 35 11 2 0.924 1.000 1.000 415 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(19), CD2(7), CD33(3), CD5(9), CD7(6), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(18), TLR2(12), TLR4(18), TLR7(18), TLR9(16) 12701615 161 89 149 61 52 24 17 50 16 2 0.545 1.000 1.000 416 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2) 12938978 142 89 134 52 46 36 15 31 14 0 0.421 1.000 1.000 417 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(8), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTR(14) 11950916 149 89 139 46 57 20 19 27 25 1 0.207 1.000 1.000 418 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 11 ARHGEF1(15), GNA12(7), GNA13(3), GNAQ(11), GNB1(3), GNGT1(1), MYL2(2), MYLK(33), PLCB1(23), PRKCA(8), ROCK1(35) 10954240 141 89 128 55 36 21 15 37 28 4 0.862 1.000 1.000 419 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(22), AP2A1(5), AP2M1(6), BIN1(6), CALM2(1), CALM3(1), DNM1(16), EPN1(10), EPS15(14), NME1(1), PICALM(9), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYNJ1(28), SYNJ2(15), SYT1(14) 15355004 171 89 155 70 48 30 17 44 32 0 0.798 1.000 1.000 420 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(27), MAP3K14(6), MAPK14(8), MAPK8(17), NFKB1(11), RELA(10), TNFRSF13B(7), TNFRSF17(4), TNFSF13(2), TNFSF13B(4), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4) 9700198 133 89 120 38 44 29 10 25 25 0 0.211 1.000 1.000 421 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(6), CR1(20), CR2(22), FCGR2B(2), HLA-DRB1(7), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 9581861 136 88 134 46 31 19 22 33 29 2 0.549 1.000 1.000 422 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 12 CD28(5), CD3D(5), CD3E(2), CD80(6), CD86(2), CTLA4(5), HLA-DRB1(7), ICOS(2), IL2(5), ITK(26), LCK(9), PTPN11(41) 5361659 115 88 90 40 20 42 12 27 12 2 0.546 1.000 1.000 423 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 24 ALDOA(2), ALDOC(3), DERA(4), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKL(7), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TALDO1(4), TKT(7), TKTL1(8), TKTL2(15) 14765877 149 88 145 55 55 20 21 39 14 0 0.373 1.000 1.000 424 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 15 ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), NAGLU(6), SPAM1(13) 12683075 155 88 139 52 51 31 14 40 19 0 0.359 1.000 1.000 425 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AGPS(6), CHPT1(4), ENPP2(27), ENPP6(11), PAFAH1B1(6), PAFAH1B3(2), PAFAH2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PPAP2A(2), PPAP2B(2), PPAP2C(3) 16146603 163 88 153 72 57 30 21 37 18 0 0.931 1.000 1.000 426 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 15 BCAT1(5), BCAT2(1), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), ILVBL(9), PANK1(7), PANK2(1), PANK4(8), PPCS(4), UPB1(9), VNN1(13) 10831817 144 88 136 46 32 26 28 41 16 1 0.196 1.000 1.000 427 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), SELE(13), SELL(5), SELP(15) 10693526 129 88 131 44 41 21 13 31 23 0 0.374 1.000 1.000 428 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 11 ARNT(9), ASPH(15), COPS5(2), CREB1(3), EDN1(3), EP300(56), EPO(1), HIF1A(16), JUN(2), NOS3(23), P4HB(6) 10468417 136 87 115 41 33 26 18 27 32 0 0.312 1.000 1.000 429 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 22 ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME3(8), PGK1(3), PGK2(10), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TKTL1(8), TKTL2(15), TPI1(3) 13081759 134 87 128 56 43 17 16 42 16 0 0.793 1.000 1.000 430 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(11), IL2RG(9), IL4(5), IL4R(6), IRS1(21), JAK1(22), JAK3(31), RPS6KB1(9), SHC1(14), STAT6(4) 9211118 132 87 106 36 33 24 17 19 37 2 0.285 1.000 1.000 431 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 20 ALG3(2), ALG5(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), DDOST(4), DPM1(3), FUT8(11), MAN1A1(14), MAN1B1(7), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), RPN1(4), RPN2(7), ST6GAL1(3) 12079498 137 87 129 51 41 31 15 29 21 0 0.765 1.000 1.000 432 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 13 EGF(8), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), PTPRB(21), RASA1(24), SHC1(14), SOS1(16), SPRY1(10), SPRY2(2), SPRY4(7), SRC(3) 11863913 128 87 114 39 26 28 20 27 26 1 0.359 1.000 1.000 433 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(2), IL6(7), IL6R(8), JAK1(22), JAK3(31), PIAS3(10), PTPRU(24), REG1A(8), SRC(3), STAT3(10) 8703815 125 87 106 41 50 22 19 15 18 1 0.242 1.000 1.000 434 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6) 11082560 143 86 125 51 34 32 15 37 24 1 0.663 1.000 1.000 435 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(15), BST1(3), C9orf95(2), CD38(5), ENPP1(17), ENPP3(12), NADK(8), NADSYN1(4), NMNAT1(3), NMNAT2(5), NMNAT3(5), NNMT(6), NNT(8), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT12(3), QPRT(2) 15172522 146 86 139 52 45 27 17 36 20 1 0.362 1.000 1.000 436 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 17 BAD(1), BCL2(2), CASP8(20), CYCS(1), FADD(1), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFKB1(11), NSMAF(13), RELA(10), RIPK1(7), SMPD1(10), TNFRSF1A(4), TRAF2(8) 12047076 145 85 136 44 45 26 15 32 27 0 0.168 1.000 1.000 437 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12) 14305523 156 85 147 50 44 16 16 39 39 2 0.659 1.000 1.000 438 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 17 AKT1(11), BAD(1), BCL2L1(1), CASP9(6), CDC42(3), CHUK(27), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(12), MAPK3(4), NFKB1(11), RAC1(2), RALA(8), RALBP1(8), RALGDS(9), RELA(10) 9003230 122 85 109 33 45 23 17 21 16 0 0.0408 1.000 1.000 439 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(27), GNB1(3), GNGT1(1), PPP2CA(3), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 9156380 120 84 111 40 45 23 7 26 19 0 0.338 1.000 1.000 440 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(16), PGAP1(14), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGW(2), PIGX(4), PIGZ(6) 16362410 139 84 130 57 24 30 13 44 28 0 0.933 1.000 1.000 441 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(25), ABCC2(23), ABCG2(17), CES1(14), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10) 15469541 155 84 137 54 44 27 20 35 28 1 0.428 1.000 1.000 442 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), HAL(12) 13277194 136 84 127 51 41 26 17 29 23 0 0.731 1.000 1.000 443 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), PON1(12), PON2(7), PON3(14) 11598072 139 83 126 46 37 31 14 34 21 2 0.351 1.000 1.000 444 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(7), CAT(8), EPX(14), LPO(10), MPO(17), MTHFR(9), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36) 7671411 118 83 106 32 54 14 13 21 16 0 0.0871 1.000 1.000 445 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 11 IL10RA(4), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(22), JAK3(31), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), TYK2(5) 10607636 127 83 106 40 32 27 10 28 29 1 0.600 1.000 1.000 446 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(7), ATP6V0C(1), CAT(8), EPX(14), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36) 7751352 117 83 105 34 55 14 13 18 17 0 0.106 1.000 1.000 447 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(7), FOS(5), GNAQ(11), JUN(2), MAPK14(8), MAPK8(17), PLCG1(19), PRKCA(8), PTK2B(13), SYT1(14) 9455777 120 82 108 51 26 31 9 36 18 0 0.944 1.000 1.000 448 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(13), ERBB4(65), NRG2(8), NRG3(18), PRKCA(8), PSEN1(4) 6360313 116 82 106 39 23 22 20 34 17 0 0.448 1.000 1.000 449 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 14 AKT1(11), CREB1(3), HRAS(4), MAPK1(3), MAPK3(4), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NTRK1(17), PLCG1(19), RPS6KA1(9), SHC1(14) 9854700 115 82 108 49 32 26 17 18 21 1 0.914 1.000 1.000 450 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(10), F2R(11), F3(2), F5(37), F7(7), FGA(23), FGB(6), FGG(7), PROC(3), PROS1(12), SERPINC1(8), TFPI(9) 11211396 140 82 131 54 37 29 20 38 16 0 0.723 1.000 1.000 451 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 14 CSNK2A1(7), DPM2(1), ELK1(4), FOS(5), HRAS(4), JUN(2), KLK2(4), MAP2K1(12), MAPK3(4), MAPK8(17), NGFR(5), PLCG1(19), SHC1(14), SOS1(16) 8943849 114 82 104 38 30 23 13 26 21 1 0.629 1.000 1.000 452 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(11), AKT2(8), AKT3(8), CDKN1A(2), ELK1(4), HRAS(4), MAP2K1(12), MAP2K2(3), NGFR(5), NTRK1(17), PIK3CD(11), SHC1(14), SOS1(16) 8630790 115 82 106 45 34 17 20 25 18 1 0.716 1.000 1.000 453 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 10 ARNTL(14), CRY1(17), CRY2(5), CSNK1D(15), CSNK1E(9), NPAS2(10), NR1D1(8), PER1(13), PER2(9), PER3(20) 10164008 120 81 105 30 44 27 8 31 9 1 0.0159 1.000 1.000 454 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 CISH(2), JAK1(22), JAK3(31), PIAS1(4), PIAS3(10), PTPRU(24), REG1A(8), SOAT1(6) 7497143 107 81 94 33 41 21 13 13 18 1 0.232 1.000 1.000 455 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(6), ALDH18A1(8), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), GAMT(6), GATM(2), GLUD1(4), NAGS(6), OAT(4), ODC1(8), OTC(17), SMS(4) 11898702 137 81 127 38 39 29 19 33 17 0 0.0859 1.000 1.000 456 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(6), ACADM(12), ACADS(4), ACADVL(6), ACSL1(9), ACSL3(12), ACSL4(10), CPT1A(13), CPT2(3), DCI(4), EHHADH(15), HADHA(12), SCP2(6), SLC25A20(2) 11733185 114 80 103 44 29 21 15 31 18 0 0.588 1.000 1.000 457 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2) 10562813 122 80 115 37 37 31 14 26 14 0 0.145 1.000 1.000 458 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 20 ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PGK1(3), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TPI1(3) 11584757 110 79 104 44 33 15 14 33 15 0 0.705 1.000 1.000 459 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4) 8382047 113 79 102 33 27 24 17 30 15 0 0.153 1.000 1.000 460 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(27), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(7), BIRC3(18), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), DIABLO(3), ENDOG(3) 9080806 111 79 93 29 20 19 16 29 27 0 0.247 1.000 1.000 461 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 21 ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TAL1(3), TALDO1(4), TKT(7) 12361874 118 79 113 44 44 16 13 34 11 0 0.475 1.000 1.000 462 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(11), BAD(1), CHRNB1(10), CHRNG(8), MUSK(15), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(10), YWHAH(5) 8089926 105 78 99 42 30 23 14 19 19 0 0.701 1.000 1.000 463 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), NCK1(1), NCKAP1(17), NTRK1(17), PIR(2), PSMA7(2), RAC1(2), WASF1(6), WASF2(5), WASF3(17), WASL(18) 10790657 130 78 123 44 36 16 19 36 23 0 0.488 1.000 1.000 464 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(14), APAF1(27), BCL2(2), CASP3(4), CASP9(6), CYCS(1), DAXX(18), FAS(9), FASLG(3), HSPB2(3), IL1A(1), MAPKAPK2(5), MAPKAPK3(6), TNF(2) 7422406 101 78 81 37 18 30 13 17 23 0 0.755 1.000 1.000 465 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(36), CPT1A(13), LEP(1), LEPR(21), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7) 10370628 122 78 115 36 38 14 12 39 19 0 0.407 1.000 1.000 466 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(35), ABCB11(19), ABCB4(28), ABCC1(25), ABCC3(11), GSTP1(1) 9746347 119 78 123 37 23 20 18 32 24 2 0.409 1.000 1.000 467 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), PAK1(11), PDGFRA(64), RAC1(2), WASL(18) 6876027 127 77 114 42 23 31 16 39 16 2 0.398 1.000 1.000 468 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), CHST1(10), CHST2(13), CHST4(8), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 7278265 103 77 101 36 51 17 4 17 14 0 0.596 1.000 1.000 469 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 11 CSF2RB(13), FOS(5), HRAS(4), IL3(6), MAP2K1(12), MAPK3(4), PTPN6(4), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20) 8532275 108 77 92 32 30 16 10 21 30 1 0.590 1.000 1.000 470 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(27), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(4), CASP8(20), CASP9(6), CYCS(1), GZMB(5), JUN(2), PRF1(8) 6864885 91 76 75 32 17 19 9 20 26 0 0.742 1.000 1.000 471 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(8), MAP2K1(12), MAP3K1(21), MAPK14(8), NCOR2(44), RARA(6), RXRA(8), THRA(6), THRB(14) 9282735 127 76 110 40 36 19 19 24 29 0 0.478 1.000 1.000 472 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 11 BCAT1(5), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), PANK1(7), PANK2(1), PANK4(8), PPCS(4), UPB1(9) 8512037 121 76 114 35 22 22 24 36 16 1 0.138 1.000 1.000 473 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(25), C5(25), C6(27), C7(11), C8A(14), C9(12) 8778922 114 75 107 35 35 11 13 30 24 1 0.385 1.000 1.000 474 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(1), IARS(10), IARS2(19), ILVBL(9), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3), VARS(7), VARS2(9) 11405023 107 75 105 41 42 17 14 19 15 0 0.723 1.000 1.000 475 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 64 FAU(2), MRPL13(8), MRPS7(4), RPL10A(3), RPL10L(4), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(4), RPL7(4), RPL8(3), RPL9(4), RPS10(2), RPS11(2), RPS13(2), RPS15A(1), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS5(2), RPS6(3), RPS7(1), RPS9(3), RPSA(1) 13694342 122 75 117 32 29 27 20 31 15 0 0.152 1.000 1.000 476 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2) 16195591 124 75 119 31 38 17 25 27 17 0 0.0476 1.000 1.000 477 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(24), CLTA(6), CLTB(3), COPA(14), GBF1(19), GPLD1(16), KDELR1(5), KDELR2(9), KDELR3(2) 11408612 110 74 106 39 31 21 14 22 22 0 0.652 1.000 1.000 478 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), PHPT1(2), RFK(1), TYR(12) 10560919 120 74 107 38 35 30 14 22 17 2 0.292 1.000 1.000 479 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 9 AKT1(11), DPM2(1), HRAS(4), KLK2(4), NTRK1(17), PLCG1(19), PRKCA(8), SHC1(14), SOS1(16) 7738727 94 74 81 41 17 21 17 19 19 1 0.947 1.000 1.000 480 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(13), KHK(4), LCT(46), MPI(4), PGM1(10), PYGL(8), PYGM(12), TPI1(3), TREH(6) 9210110 106 73 98 34 34 22 15 28 7 0 0.170 1.000 1.000 481 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), IDS(5), LCT(46), NAGLU(6) 9533781 106 73 97 37 39 21 10 25 11 0 0.315 1.000 1.000 482 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELE(13), SELL(5) 8270708 100 73 98 38 27 17 9 26 21 0 0.696 1.000 1.000 483 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 16 IL18(3), ITGB1(13), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LAT(3), MAP2K1(12), MAPK3(4), PAK1(11), PTK2B(13), PTPN6(4), RAC1(2), SYK(8), VAV1(24) 9838256 116 73 111 39 32 26 11 32 15 0 0.431 1.000 1.000 484 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42) 11478171 122 71 108 39 37 15 21 31 18 0 0.356 1.000 1.000 485 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(5), CD3D(5), CD3E(2), IFNG(3), IL2(5), IL2RA(6), IL4(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), TOB1(8), TOB2(2) 7211875 118 71 102 39 37 29 13 23 16 0 0.297 1.000 1.000 486 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(9), CYB5R3(2), GCK(6), GFPT1(6), GNE(8), GNPDA1(2), GNPDA2(3), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), PGM3(7), RENBP(3), UAP1(6) 11659061 103 70 97 31 35 24 12 19 13 0 0.192 1.000 1.000 487 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(13), AMT(2), ATIC(14), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6) 12911227 107 70 101 51 33 17 16 22 17 2 0.944 1.000 1.000 488 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(5), CSF3(3), HLA-DRB1(7), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL11(6), IL12A(2), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), LTA(1), PDGFA(2), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2) 8684335 103 70 93 45 30 18 9 29 14 3 0.887 1.000 1.000 489 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(11), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK1(3), MAPK3(4), MYC(5), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10), TNF(2) 9427428 101 69 96 46 30 17 16 22 16 0 0.870 1.000 1.000 490 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(2), FH(10), IDH2(17), MDH1(8), OGDH(14), SDHA(14), SUCLA2(9) 6549626 81 69 71 29 22 15 8 22 14 0 0.581 1.000 1.000 491 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 10 AKT1(11), CAT(8), GH1(5), GHR(12), HRAS(4), IGF1(6), IGF1R(22), SHC1(14), SOD2(4) 6289138 86 69 74 35 27 13 12 19 14 1 0.768 1.000 1.000 492 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 21 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), FDXR(5), SHMT1(7) 10471669 103 69 91 40 31 27 13 21 11 0 0.635 1.000 1.000 493 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(6), JAK1(22), PTPRU(24), REG1A(8), STAT1(17), STAT2(12), TYK2(5) 8526878 101 69 92 27 39 21 8 18 14 1 0.133 1.000 1.000 494 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(11), BAD(1), CASP9(6), CHUK(27), GH1(5), GHR(12), NFKB1(11), NFKBIA(1), PDPK1(4), PPP2CA(3), RELA(10), YWHAH(5) 7217989 96 68 84 31 31 21 12 21 11 0 0.293 1.000 1.000 495 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10003471 98 68 86 39 30 26 13 19 10 0 0.675 1.000 1.000 496 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(14), EIF2AK4(23), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF5(6), GSK3B(17), PPP1CA(2) 7874754 85 68 72 21 14 31 6 15 19 0 0.136 1.000 1.000 497 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10003471 98 68 86 39 30 26 13 19 10 0 0.675 1.000 1.000 498 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(2), BNIP1(5), GOSR1(5), GOSR2(6), SEC22B(3), SNAP23(2), SNAP25(2), SNAP29(4), STX11(7), STX12(6), STX16(7), STX17(2), STX18(3), STX19(4), STX2(6), STX3(4), STX4(3), STX5(11), STX6(2), STX7(4), STX8(7), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(4), VAMP4(4), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1), YKT6(1) 11075338 124 68 111 35 39 12 11 29 33 0 0.381 1.000 1.000 499 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(5), CD86(2), HLA-DRB1(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), IL2(5), IL2RA(6), IL4(5), IL4R(6) 8376012 99 68 89 32 23 19 14 24 16 3 0.324 1.000 1.000 500 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10003471 98 68 86 39 30 26 13 19 10 0 0.675 1.000 1.000 501 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 10 ADCY1(27), ADRB2(3), CFTR(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SLC9A3R1(3) 7469956 89 67 85 28 28 19 5 24 13 0 0.217 1.000 1.000 502 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2) 9410902 88 67 89 34 19 21 9 26 13 0 0.734 1.000 1.000 503 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(4), GALNT10(8), GALNT2(15), GALNT3(15), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GCNT1(9), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4) 9088904 93 67 91 39 35 18 14 12 14 0 0.737 1.000 1.000 504 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(13), AMT(2), ATIC(14), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6) 12541796 102 67 94 49 30 18 15 21 16 2 0.941 1.000 1.000 505 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(11), PLCB1(23), PLCG1(19), PRKCA(8), VAV1(24) 6454376 85 67 78 38 28 22 11 18 6 0 0.875 1.000 1.000 506 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 14 ADRB2(3), AKT1(11), ANXA1(4), CALM2(1), CALM3(1), GNB1(3), GNGT1(1), NFKB1(11), NOS3(23), NPPA(1), NR3C1(11), RELA(10), SYT1(14) 7800652 94 66 77 36 28 26 9 15 16 0 0.669 1.000 1.000 507 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(19), PSMD11(8), PSMD12(6), PSMD13(8), PSMD2(4), PSMD6(8) 11487542 97 66 88 37 25 24 11 25 12 0 0.728 1.000 1.000 508 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10) 11835122 102 66 88 30 27 14 13 18 30 0 0.450 1.000 1.000 509 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(5), CD3D(5), CD3E(2), CD4(4), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 7473398 102 66 96 41 25 16 15 23 23 0 0.782 1.000 1.000 510 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 15 ALOX12(4), ALOX15(5), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(3), LTA4H(2), PLA2G6(10), PTGDS(2), PTGES(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 9336087 91 65 90 37 34 11 11 22 13 0 0.679 1.000 1.000 511 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(5), CD3D(5), CD3E(2), CD8A(2), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 7012128 100 65 94 39 27 16 13 22 22 0 0.712 1.000 1.000 512 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(3), EPO(1), FLT3(36), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(7), IL9(2), KITLG(3), TGFB1(2), TGFB2(10), TGFB3(2) 5817287 85 64 75 40 21 21 7 23 12 1 0.940 1.000 1.000 513 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(21), ESR2(8), ITPKA(3), PDE1A(10), PDE1B(11), PLCB1(23), PRL(4), TRH(8), VIP(3) 6133386 91 64 86 27 27 16 14 18 16 0 0.263 1.000 1.000 514 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 14 B3GAT1(6), B3GAT2(1), B3GAT3(2), B4GALT7(2), CHPF(10), CHST11(6), CHST12(6), CHST14(1), CHST3(7), CHSY1(14), DSE(10), UST(12), XYLT1(14) 7670173 91 63 82 48 40 16 12 15 7 1 0.922 1.000 1.000 515 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(6), ICAM1(4), ITGAL(21), ITGAM(14), ITGB2(18), SELE(13), SELL(5) 6781644 81 63 87 27 30 12 8 16 15 0 0.363 1.000 1.000 516 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), NAT1(1), NAT2(3), XDH(19) 5673381 77 62 72 34 25 13 10 21 8 0 0.858 1.000 1.000 517 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PCYT1A(5), PCYT1B(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2) 9317773 82 62 85 36 19 18 9 23 13 0 0.915 1.000 1.000 518 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(2), HMOX1(6), IL10(2), IL10RA(4), IL10RB(7), IL1A(1), IL6(7), JAK1(22), STAT1(17), STAT3(10), STAT5A(10), TNF(2) 8331374 92 62 80 35 30 16 6 22 17 1 0.735 1.000 1.000 519 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), STAT3(10), TYK2(5) 6186524 75 62 61 24 21 21 6 13 13 1 0.522 1.000 1.000 520 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), IMPA2(4), ISYNA1(6), PGM1(10), PGM3(7), TGDS(1) 7573819 80 61 75 33 33 12 8 18 9 0 0.607 1.000 1.000 521 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(8), IFNAR1(7), IFNAR2(4), IFNB1(6), JAK1(22), STAT1(17), STAT2(12), TYK2(5) 7400082 81 61 70 24 22 18 6 21 13 1 0.355 1.000 1.000 522 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(13), ADSS(8), DHFR(1), HPRT1(2), IMPDH1(4), MTHFD2(2), POLB(6), POLD1(20), POLG(9), PRPS2(6), RRM1(3), SRM(1) 8300600 75 61 74 31 28 7 12 14 14 0 0.783 1.000 1.000 523 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(3), DFFA(6), DFFB(2), ENDOG(3), GZMB(5), HMGB1(2), HMGB2(2), TOP2A(24), TOP2B(25) 6083306 76 60 71 18 10 15 8 22 21 0 0.439 1.000 1.000 524 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(6), FDFT1(4), FDPS(6), GGCX(11), GGPS1(5), HMGCR(7), IDI1(4), IDI2(3), LSS(5), MVD(3), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2), TM7SF2(2) 12365251 92 60 90 39 29 8 13 28 14 0 0.921 1.000 1.000 525 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 13 CCR5(11), CD2(7), CD3D(5), CD3E(2), CD4(4), CXCR3(5), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), STAT4(13), TYK2(5) 8337298 83 60 75 30 11 21 15 26 10 0 0.618 1.000 1.000 526 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(14), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(3), CDK5R1(5), CSNK1A1(3), CSNK1D(15), GSK3B(17), MAPT(11), PPP2CA(3) 5698340 81 60 77 27 29 20 5 17 10 0 0.413 1.000 1.000 527 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL15(1), IL16(18), IL18(3), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL8(6), IL9(2), LTA(1), TNF(2) 6679783 81 59 72 43 23 16 8 25 9 0 0.954 1.000 1.000 528 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(12), ACO2(7), AFMID(3), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2) 9484795 83 59 76 26 25 10 13 24 11 0 0.242 1.000 1.000 529 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(15), CD38(5), ENPP1(17), ENPP3(12), NADSYN1(4), NMNAT1(3), NMNAT2(5), NNMT(6), NNT(8), NT5C(1), NT5E(7), NT5M(3), QPRT(2) 10368086 88 59 81 32 24 19 10 22 12 1 0.425 1.000 1.000 530 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(14), CD44(6), CSF1(5), FCGR3A(5), IL1B(5), IL6R(8), SELL(5), SPN(6), TGFB1(2), TGFB2(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(8), TNFSF8(6) 8798591 87 59 89 29 26 12 16 19 14 0 0.272 1.000 1.000 531 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(18), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(3), CDK2(5), CDK4(4), CDKN1B(6), CDKN2A(9), E2F2(7), E2F4(2), PRB1(5) 5854733 71 59 67 30 15 14 9 19 14 0 0.783 1.000 1.000 532 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(12), ACO2(7), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2) 9047504 80 58 73 24 24 10 13 22 11 0 0.201 1.000 1.000 533 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(5), FOSL1(1), FOSL2(5), IFNAR1(7), IFNAR2(4), IFNB1(6), MAPK8(17), NFKB1(11), RELA(10), TNFRSF11A(6), TNFSF11(8), TRAF6(4) 7427319 84 58 82 32 25 17 9 18 15 0 0.615 1.000 1.000 534 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 13 CALM2(1), CALM3(1), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CAMKK1(2), CAMKK2(9), CREB1(3), SYT1(14) 7323562 73 57 67 36 16 20 9 14 14 0 0.942 1.000 1.000 535 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 15 CARS(11), CARS2(6), CDO1(3), CTH(6), GOT1(7), GOT2(2), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), SDS(3), SULT1B1(6), SULT1C2(6), SULT1C4(3), SULT4A1(6) 8113727 84 57 80 23 30 10 11 23 10 0 0.164 1.000 1.000 536 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 11 AHCY(8), CBS(4), CTH(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), PAPSS1(5), PAPSS2(7), SCLY(12), SEPHS1(7) 7802157 85 57 78 24 26 10 14 20 15 0 0.133 1.000 1.000 537 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10) 6419614 77 56 76 26 24 10 8 23 12 0 0.514 1.000 1.000 538 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(6), B3GALT5(5), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST8SIA1(10) 6872877 84 56 81 28 30 10 9 23 12 0 0.434 1.000 1.000 539 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), SIRT1(8), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(5) 7751289 68 56 63 25 21 11 10 13 13 0 0.530 1.000 1.000 540 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(7), UBE2A(5), UBE3A(25) 9226684 84 56 82 30 21 17 11 23 12 0 0.570 1.000 1.000 541 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(11), GNB1(3), GNGT1(1), HTR2C(15), PLCB1(23), TUB(14) 4961287 71 56 70 30 27 13 7 18 6 0 0.764 1.000 1.000 542 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 7 CD3D(5), CD3E(2), GZMB(5), ICAM1(4), ITGAL(21), ITGB2(18), PRF1(8) 4795831 63 55 58 28 27 9 3 9 15 0 0.805 1.000 1.000 543 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(5), GSR(5), GSS(9), IL8(6), NFKB1(11), NOX1(4), RELA(10), TNF(2), XDH(19) 6903227 71 55 66 23 17 22 7 11 14 0 0.457 1.000 1.000 544 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(8), ME1(14), PC(16), PDHA1(8), SLC25A1(1), SLC25A11(2) 6057386 63 55 57 21 23 15 7 11 7 0 0.344 1.000 1.000 545 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(5), MAX(5), MYC(5), SP1(7), SP3(13), WT1(32) 4179137 67 55 57 30 14 22 15 9 7 0 0.691 1.000 1.000 546 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(5), CHAT(17), CHKA(6), PCYT1A(5), PDHA1(8), PDHA2(17), PEMT(2), SLC18A3(12) 4591510 72 54 70 43 30 9 10 18 5 0 0.968 1.000 1.000 547 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 12 CYSLTR1(9), GPR109B(5), GPR161(13), GPR171(11), GPR18(5), GPR34(11), GPR39(4), GPR45(14), GPR65(2), GPR68(5), GPR75(10) 6288152 89 54 80 40 26 14 7 23 18 1 0.915 1.000 1.000 548 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 9 ANPEP(19), CKM(7), FBL(6), GPT(7), LDHB(8), LDHC(4), MAPK14(8), NCL(12) 5543390 71 54 66 31 20 12 11 24 4 0 0.784 1.000 1.000 549 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(7), FARSA(6), FARSB(12), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4), YARS2(7) 6150246 78 53 71 25 19 8 12 27 12 0 0.474 1.000 1.000 550 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 5223575 64 53 59 19 26 14 3 12 9 0 0.439 1.000 1.000 551 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), PGM1(10), PGM3(7), TGDS(1) 6907599 70 53 65 29 28 11 7 17 7 0 0.652 1.000 1.000 552 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(28), GNA12(7), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6) 7123468 64 52 60 17 17 10 7 17 13 0 0.286 1.000 1.000 553 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(7), B3GALT1(3), B3GALT2(10), B3GALT5(5), B3GNT5(3), FUT1(11), FUT2(7), FUT3(6), ST3GAL3(12), ST3GAL4(4) 4700899 68 52 64 25 31 7 4 15 11 0 0.675 1.000 1.000 554 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(11), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10) 5746565 64 52 61 28 21 12 7 15 9 0 0.840 1.000 1.000 555 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), TYK2(5) 5480414 58 52 48 19 14 20 0 16 7 1 0.566 1.000 1.000 556 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), TYK2(5) 5480414 58 52 48 19 14 20 0 16 7 1 0.566 1.000 1.000 557 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(3), HBXIP(4), HRAS(4), PTK2B(13), SHC1(14), SOS1(16), SRC(3) 5655159 57 51 51 18 7 11 9 13 16 1 0.688 1.000 1.000 558 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 7 CAMK1G(7), HDAC9(20), MEF2A(7), MEF2C(15), MEF2D(3), YWHAH(5) 4268471 57 51 67 29 16 8 3 19 10 1 0.967 1.000 1.000 559 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14) 8476258 73 51 71 20 26 13 8 16 10 0 0.273 1.000 1.000 560 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 5164061 61 50 61 26 29 6 6 11 9 0 0.710 1.000 1.000 561 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 5164061 61 50 61 26 29 6 6 11 9 0 0.710 1.000 1.000 562 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(11), NEK1(20) 4166285 58 50 55 22 10 12 3 16 16 1 0.923 1.000 1.000 563 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), RFK(1), TYR(12) 6843528 74 49 65 20 20 19 9 15 9 2 0.146 1.000 1.000 564 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(2), CDK2(5), CDK4(4), CDKN1A(2), CDKN1B(6), CDKN2A(9), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(5) 4661823 59 49 55 21 10 14 8 11 16 0 0.632 1.000 1.000 565 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(3), ENO3(6), FARS2(7), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4) 5934868 65 48 59 28 15 7 14 20 9 0 0.857 1.000 1.000 566 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 8 CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CSK(5), PRKCA(8), PTPRA(6), SRC(3) 6057822 58 48 58 24 16 12 7 18 5 0 0.680 1.000 1.000 567 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(5), UBE2A(5), UBE2B(3), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(4), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(25) 7020427 74 48 72 22 20 13 6 17 18 0 0.275 1.000 1.000 568 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 10 ARRB1(4), GNB1(3), GNGT1(1), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8) 5300730 51 47 50 26 16 13 1 11 10 0 0.900 1.000 1.000 569 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), ECHS1(4), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), MECR(4), PPT1(1), PPT2(5) 5881095 54 47 53 18 14 9 6 13 12 0 0.456 1.000 1.000 570 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(10), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3) 7048795 62 46 61 27 20 11 9 14 8 0 0.859 1.000 1.000 571 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 ARNT(9), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(16), NFKB1(11), NFKBIA(1), RELA(10), SOD2(4) 6983437 61 45 58 22 18 9 9 11 14 0 0.625 1.000 1.000 572 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(15), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(6), APOBEC3F(2), APOBEC3G(8), APOBEC4(9) 5191508 57 44 56 17 22 5 10 10 10 0 0.312 1.000 1.000 573 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 8 ENO1(3), GPI(6), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(12), TPI1(3) 5302809 51 43 47 27 20 8 4 13 6 0 0.945 1.000 1.000 574 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 11 CD2(7), CD34(7), CD3D(5), CD3E(2), CD4(4), CD8A(2), CSF3(3), IL3(6), IL6(7), IL8(6), KITLG(3) 3875790 52 43 44 23 12 14 5 13 8 0 0.748 1.000 1.000 575 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3) 4996405 57 43 55 15 17 6 5 10 19 0 0.269 1.000 1.000 576 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(39), GLS(2), GLUD1(4), GOT1(7) 5422364 59 43 52 16 14 14 10 14 7 0 0.214 1.000 1.000 577 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(3), FOS(5), JUN(2), KEAP1(5), MAPK1(3), MAPK14(8), MAPK8(17), NFE2L2(7), PRKCA(8) 5625930 58 42 57 24 13 12 5 20 8 0 0.803 1.000 1.000 578 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 5 ARNTL(14), CRY1(17), CRY2(5), CSNK1E(9), PER1(13) 4457906 58 42 49 16 20 11 2 20 4 1 0.284 1.000 1.000 579 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(11), MBTPS1(14), MBTPS2(2), SCAP(9), SREBF1(8), SREBF2(10) 7338535 55 42 54 28 16 13 8 10 8 0 0.839 1.000 1.000 580 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), IDI1(4), LSS(5), MVD(3), NQO1(1), NQO2(3), PMVK(2), SC5DL(9), SQLE(2) 6633975 50 41 49 18 16 8 7 15 4 0 0.508 1.000 1.000 581 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 7 LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NFS1(6), PHPT1(2), THTPA(2) 4094658 48 41 46 15 17 8 6 9 8 0 0.519 1.000 1.000 582 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 13 BPNT1(9), CHST11(6), CHST12(6), PAPSS1(5), PAPSS2(7), SULT1A1(4), SULT1A2(4), SULT1E1(6), SULT2A1(6), SULT2B1(4), SUOX(5) 6526346 62 41 58 21 20 9 5 20 8 0 0.560 1.000 1.000 583 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(3), FOS(5), FYN(17), JUN(2), MAPK14(8), THBS1(14) 5017622 53 41 48 20 14 9 6 11 13 0 0.587 1.000 1.000 584 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(12), AOC3(10), CES1(14), ESD(5) 4004121 45 39 44 23 15 6 8 11 5 0 0.869 1.000 1.000 585 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(7), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), ST3GAL3(12) 2690635 48 39 45 19 26 5 3 9 5 0 0.593 1.000 1.000 586 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(8), PLCG1(19), PRKCA(8), PTK2B(13) 4596991 48 39 44 26 15 12 6 9 6 0 0.967 1.000 1.000 587 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(8), F13B(12), HSD17B1(2), HSD17B2(7), HSD17B3(6), HSD17B4(9), HSD3B1(6), HSD3B2(4) 5650953 54 39 52 23 18 10 7 13 6 0 0.646 1.000 1.000 588 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 CYP51A1(3), DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), HMGCS1(1), IDI1(4), LSS(5), MVD(3), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2) 8185421 55 38 55 21 17 7 7 18 6 0 0.711 1.000 1.000 589 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(9), GAD1(17), HDC(14), PNMT(3), TPH1(4) 3543730 47 38 45 19 14 7 3 18 5 0 0.718 1.000 1.000 590 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(11), CYP2E1(11), NR1I3(5), PTGS1(10), PTGS2(10) 3714878 47 37 47 19 22 4 8 9 4 0 0.722 1.000 1.000 591 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(10), CYP11A1(7), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 4653077 45 37 43 26 18 7 7 7 6 0 0.916 1.000 1.000 592 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 5 ADCY1(27), GNB1(3), GNGT1(1), PRKACA(2), PRKAR1A(8) 2953999 41 37 38 17 18 10 2 8 3 0 0.574 1.000 1.000 593 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(11), NR1H3(16), NR1H4(9), RXRA(8) 3464000 46 36 39 21 14 9 6 6 11 0 0.904 1.000 1.000 594 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(12), ALAS2(12), CPOX(4), FECH(4), HMBS(5), PPOX(5), UROD(3), UROS(5) 5397606 51 36 47 13 21 8 5 11 6 0 0.344 1.000 1.000 595 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(6), ACADM(12), ACADS(4), ACAT1(7), ECHS1(4), HADHA(12) 3709116 45 35 43 19 12 6 6 8 13 0 0.746 1.000 1.000 596 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(7), GOT2(2), TAT(16), TYR(12) 3360193 42 35 34 22 11 6 11 11 3 0 0.911 1.000 1.000 597 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMB8(9), PSMB9(4) 5875820 44 35 43 19 9 5 5 17 8 0 0.855 1.000 1.000 598 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(7), ACAT2(9), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(1), HMGCS2(6), OXCT1(3), OXCT2(3) 5121005 36 33 34 14 13 6 3 7 7 0 0.701 1.000 1.000 599 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(7), CSF1(5), IL6(7), LDLR(11), LPL(12) 3651205 42 33 39 19 14 12 3 7 6 0 0.692 1.000 1.000 600 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(12), NR3C1(11), PPARG(4), RETN(2), RXRA(8), TNF(2) 3753014 41 33 37 25 10 8 8 8 7 0 0.970 1.000 1.000 601 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), DHFR(1), FPGS(4), GGH(2), SPR(7) 3636482 37 32 37 15 12 7 5 9 4 0 0.609 1.000 1.000 602 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14) 3089563 36 31 33 21 18 7 2 5 3 1 0.942 1.000 1.000 603 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14) 3089563 36 31 33 21 18 7 2 5 3 1 0.942 1.000 1.000 604 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(6), PLCD1(10), PRKCA(8), TGM2(17) 3400591 41 31 40 21 17 6 3 12 3 0 0.853 1.000 1.000 605 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 6 CARS(11), CTH(6), GOT1(7), GOT2(2), LDHB(8), LDHC(4) 4053858 38 30 36 12 15 4 5 10 4 0 0.439 1.000 1.000 606 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 7 OXA1L(7), SEC61A2(4), SRP19(1), SRP54(4), SRP68(13), SRP72(9) 4436588 38 29 38 10 9 7 6 13 3 0 0.298 1.000 1.000 607 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(5), IL1B(5), MST1(5), MST1R(14), TNF(2) 3518329 31 28 28 11 11 5 4 8 3 0 0.496 1.000 1.000 608 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 8 ASAH1(4), CAMP(1), CREB1(3), CREB3(6), CREB5(8), MAPK1(3), SRC(3), TERF2IP(4) 4144209 32 26 32 15 5 5 4 11 7 0 0.867 1.000 1.000 609 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(2), CCR3(11), HLA-DRB1(7), IL3(6) 1585747 26 25 21 12 5 9 0 7 3 2 0.937 1.000 1.000 610 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(8), ARG1(2), GLS(2), GLUD1(4), OAT(4), PRODH(5) 3682869 25 23 24 12 11 7 2 1 4 0 0.760 1.000 1.000 611 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(12), SNAP25(2), STX1A(4), VAMP2(1) 2245011 23 23 20 11 7 6 3 6 1 0 0.907 1.000 1.000 612 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(7), GOT2(2), TAT(16) 1889276 25 21 19 13 7 1 9 5 3 0 0.867 1.000 1.000 613 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 ASRGL1(1), GBA(4), GBA3(3), SHMT1(7), SHMT2(5) 2992441 20 19 23 11 8 1 2 4 5 0 0.935 1.000 1.000 614 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(7), ACAT2(9), HMGCL(1), OXCT1(3) 2416096 20 18 18 10 3 5 3 5 4 0 0.890 1.000 1.000 615 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(6), IFNG(3), IL12A(2), IL12B(1), IL18(3), IL2(5) 2128698 20 15 19 16 1 4 6 7 2 0 0.995 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 365947 1 1 1 2 1 0 0 0 0 0 0.955 1.000 1.000