Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	58.0	464.0	8.0	-0.258	0.121	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by the Hedgehog family	56.0	2913.0	52.0	-0.512	0.217	1000.0	-1000.0	-0.073	-1000.0
FOXA2 and FOXA3 transcription factor networks	51.0	2350.0	46.0	-0.856	0.01	1000.0	-1000.0	-0.099	-1000.0
Glypican 1 network	28.0	1349.0	48.0	-0.301	0.042	1000.0	-1000.0	-0.045	-1000.0
p75(NTR)-mediated signaling	25.0	3145.0	125.0	-0.245	0.01	1000.0	-1000.0	-0.094	-1000.0
Ephrin B reverse signaling	24.0	1159.0	48.0	-0.184	0.077	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	23.0	1410.0	60.0	-0.431	0.01	1000.0	-1000.0	-0.171	-1000.0
IL4-mediated signaling events	22.0	2085.0	91.0	-0.829	0.577	1000.0	-1000.0	-0.175	-1000.0
TCGA08_p53	22.0	158.0	7.0	-0.198	0.105	1000.0	-1000.0	-0.015	-1000.0
Glucocorticoid receptor regulatory network	19.0	2228.0	114.0	-0.68	0.33	1000.0	-1000.0	-0.077	-1000.0
Wnt signaling	18.0	127.0	7.0	-0.11	0.001	1000.0	-1000.0	-0.028	-1000.0
BMP receptor signaling	16.0	1305.0	81.0	-0.262	0.032	1000.0	-1000.0	-0.089	-1000.0
Ephrin A  reverse signaling	15.0	107.0	7.0	-0.048	0.0	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	15.0	1192.0	76.0	-0.426	0.017	1000.0	-1000.0	-0.188	-1000.0
LPA receptor mediated events	15.0	1626.0	102.0	-0.215	0.025	1000.0	-1000.0	-0.084	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	497.0	34.0	-0.102	0.01	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	14.0	953.0	68.0	-0.26	0.102	1000.0	-1000.0	-0.136	-1000.0
EGFR-dependent Endothelin signaling events	14.0	301.0	21.0	-0.151	0.01	1000.0	-1000.0	-0.07	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1689.0	120.0	-0.346	0.145	1000.0	-1000.0	-0.074	-1000.0
Visual signal transduction: Rods	14.0	771.0	52.0	-0.198	0.01	1000.0	-1000.0	-0.078	-1000.0
Visual signal transduction: Cones	13.0	496.0	38.0	-0.149	0.01	1000.0	-1000.0	-0.056	-1000.0
S1P5 pathway	13.0	228.0	17.0	-0.177	0.113	1000.0	-1000.0	-0.055	-1000.0
Endothelins	13.0	1282.0	96.0	-0.237	0.019	1000.0	-1000.0	-0.076	-1000.0
BCR signaling pathway	13.0	1308.0	99.0	-0.158	0.013	1000.0	-1000.0	-0.087	-1000.0
Arf6 signaling events	12.0	770.0	62.0	-0.151	0.01	1000.0	-1000.0	-0.065	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1249.0	97.0	-0.199	0.023	1000.0	-1000.0	-0.094	-1000.0
Reelin signaling pathway	12.0	708.0	56.0	-0.164	0.01	1000.0	-1000.0	-0.073	-1000.0
EPHB forward signaling	12.0	1094.0	85.0	-0.119	0.089	1000.0	-1000.0	-0.087	-1000.0
IL12-mediated signaling events	11.0	997.0	87.0	-0.188	0.048	1000.0	-1000.0	-0.129	-1000.0
Noncanonical Wnt signaling pathway	11.0	291.0	26.0	-0.11	0.01	1000.0	-1000.0	-0.082	-1000.0
amb2 Integrin signaling	11.0	973.0	82.0	-0.128	0.01	1000.0	-1000.0	-0.081	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	939.0	82.0	-0.128	0.01	1000.0	-1000.0	-0.089	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1055.0	93.0	-0.141	0.076	1000.0	-1000.0	-0.085	-1000.0
Osteopontin-mediated events	10.0	401.0	38.0	-0.161	0.013	1000.0	-1000.0	-0.098	-1000.0
Thromboxane A2 receptor signaling	10.0	1121.0	105.0	-0.151	0.021	1000.0	-1000.0	-0.066	-1000.0
Syndecan-2-mediated signaling events	10.0	734.0	69.0	-0.152	0.03	1000.0	-1000.0	-0.054	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	474.0	44.0	-0.116	0.01	1000.0	-1000.0	-0.049	-1000.0
Syndecan-4-mediated signaling events	10.0	735.0	67.0	-0.152	0.012	1000.0	-1000.0	-0.088	-1000.0
Syndecan-1-mediated signaling events	9.0	331.0	34.0	-0.162	0.01	1000.0	-1000.0	-0.062	-1000.0
IL1-mediated signaling events	9.0	605.0	62.0	-0.185	0.052	1000.0	-1000.0	-0.083	-1000.0
Retinoic acid receptors-mediated signaling	9.0	531.0	58.0	-0.192	0.011	1000.0	-1000.0	-0.075	-1000.0
Effects of Botulinum toxin	9.0	234.0	26.0	-0.099	0.01	1000.0	-1000.0	-0.062	-1000.0
Glypican 2 network	9.0	36.0	4.0	-0.028	-1000.0	1000.0	-1000.0	-0.035	-1000.0
IGF1 pathway	9.0	537.0	57.0	-0.09	0.019	1000.0	-1000.0	-0.089	-1000.0
ErbB4 signaling events	8.0	576.0	69.0	-0.213	0.051	1000.0	-1000.0	-0.083	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	238.0	28.0	-0.177	0.01	1000.0	-1000.0	-0.057	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	552.0	65.0	-0.464	0.036	1000.0	-1000.0	-0.065	-1000.0
Nectin adhesion pathway	8.0	506.0	63.0	-0.077	0.01	1000.0	-1000.0	-0.071	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	265.0	31.0	-0.168	0.011	1000.0	-1000.0	-0.09	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.018	-1000.0	1000.0	-1000.0	-0.016	-1000.0
S1P4 pathway	8.0	218.0	25.0	-0.177	0.013	1000.0	-1000.0	-0.055	-1000.0
LPA4-mediated signaling events	7.0	90.0	12.0	-0.053	0.017	1000.0	-1000.0	-0.028	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	391.0	54.0	-0.117	0.022	1000.0	-1000.0	-0.103	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	446.0	61.0	-0.185	0.029	1000.0	-1000.0	-0.063	-1000.0
FAS signaling pathway (CD95)	7.0	339.0	47.0	-0.118	0.013	1000.0	-1000.0	-0.046	-1000.0
Syndecan-3-mediated signaling events	7.0	262.0	35.0	-0.114	0.01	1000.0	-1000.0	-0.063	-1000.0
Integrins in angiogenesis	7.0	656.0	84.0	-0.165	0.012	1000.0	-1000.0	-0.088	-1000.0
Canonical Wnt signaling pathway	7.0	403.0	51.0	-0.185	0.061	1000.0	-1000.0	-0.061	-1000.0
Plasma membrane estrogen receptor signaling	7.0	637.0	86.0	-0.089	0.021	1000.0	-1000.0	-0.084	-1000.0
Angiopoietin receptor Tie2-mediated signaling	7.0	653.0	88.0	-0.107	0.03	1000.0	-1000.0	-0.112	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	245.0	33.0	-0.266	0.03	1000.0	-1000.0	-0.061	-1000.0
ErbB2/ErbB3 signaling events	6.0	409.0	65.0	-0.113	0.027	1000.0	-1000.0	-0.069	-1000.0
Caspase cascade in apoptosis	6.0	453.0	74.0	-0.075	0.016	1000.0	-1000.0	-0.048	-1000.0
Coregulation of Androgen receptor activity	6.0	458.0	76.0	-0.325	0.02	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	6.0	530.0	76.0	-0.151	0.016	1000.0	-1000.0	-0.074	-1000.0
S1P1 pathway	6.0	219.0	36.0	-0.061	0.01	1000.0	-1000.0	-0.059	-1000.0
IL27-mediated signaling events	6.0	323.0	51.0	-0.193	0.011	1000.0	-1000.0	-0.078	-1000.0
FOXM1 transcription factor network	6.0	327.0	51.0	-0.272	0.12	1000.0	-1000.0	-0.195	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	484.0	78.0	-0.112	0.028	1000.0	-1000.0	-0.072	-1000.0
Regulation of Androgen receptor activity	6.0	453.0	70.0	-0.338	0.02	1000.0	-1000.0	-0.064	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	738.0	136.0	-0.426	0.062	1000.0	-1000.0	-0.07	-1000.0
Cellular roles of Anthrax toxin	5.0	213.0	39.0	-0.047	0.014	1000.0	-1000.0	-0.028	-1000.0
EPO signaling pathway	5.0	304.0	55.0	-0.111	0.01	1000.0	-1000.0	-0.092	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	195.0	37.0	-0.114	0.028	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	293.0	52.0	-0.13	0.019	1000.0	-1000.0	-0.064	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	423.0	74.0	-0.17	0.053	1000.0	-1000.0	-0.087	-1000.0
S1P3 pathway	5.0	221.0	42.0	-0.055	0.015	1000.0	-1000.0	-0.057	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	78.0	17.0	-0.03	0.023	1000.0	-1000.0	-0.063	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	381.0	85.0	-0.052	0.032	1000.0	-1000.0	-0.07	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	66.0	15.0	-0.014	0.022	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	4.0	259.0	58.0	-0.114	0.032	1000.0	-1000.0	-0.08	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	198.0	45.0	-0.051	0.03	1000.0	-1000.0	-0.086	-1000.0
Regulation of p38-alpha and p38-beta	4.0	252.0	54.0	-0.132	0.01	1000.0	-1000.0	-0.06	-1000.0
Nongenotropic Androgen signaling	4.0	251.0	52.0	-0.051	0.025	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events	4.0	304.0	73.0	-0.132	0.012	1000.0	-1000.0	-0.069	-1000.0
Regulation of Telomerase	4.0	431.0	102.0	-0.152	0.038	1000.0	-1000.0	-0.108	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	73.0	17.0	-0.026	0.01	1000.0	-1000.0	-0.048	-1000.0
IFN-gamma pathway	3.0	236.0	68.0	-0.116	0.035	1000.0	-1000.0	-0.092	-1000.0
Ceramide signaling pathway	3.0	294.0	76.0	-0.151	0.039	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by HDAC Class III	3.0	148.0	40.0	-0.14	0.019	1000.0	-1000.0	-0.042	-1000.0
TRAIL signaling pathway	3.0	163.0	48.0	-0.029	0.032	1000.0	-1000.0	-0.065	-1000.0
IL6-mediated signaling events	3.0	254.0	75.0	-0.071	0.053	1000.0	-1000.0	-0.103	-1000.0
IL2 signaling events mediated by STAT5	3.0	71.0	22.0	-0.037	0.035	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	3.0	332.0	97.0	-0.074	0.045	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by PRL	3.0	125.0	34.0	-0.134	0.025	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling events	3.0	18.0	5.0	-0.018	0.01	1000.0	-1000.0	-0.044	-1000.0
Canonical NF-kappaB pathway	2.0	88.0	39.0	-0.047	0.054	1000.0	-1000.0	-0.08	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	-0.01	0.004	1000.0	-1000.0	-0.034	-1000.0
Arf6 downstream pathway	2.0	128.0	43.0	-0.078	0.037	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	2.0	94.0	43.0	-0.047	0.052	1000.0	-1000.0	-0.105	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	231.0	83.0	-0.195	0.041	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	339.0	125.0	-0.038	0.052	1000.0	-1000.0	-0.106	-1000.0
TCGA08_rtk_signaling	2.0	62.0	26.0	-0.029	0.035	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	190.0	76.0	-0.079	0.048	1000.0	-1000.0	-0.083	-1000.0
Insulin Pathway	2.0	186.0	74.0	-0.095	0.032	1000.0	-1000.0	-0.08	-1000.0
Rapid glucocorticoid signaling	2.0	42.0	20.0	-0.017	0.01	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in keratinocytes	2.0	93.0	43.0	-0.029	0.032	1000.0	-1000.0	-0.063	-1000.0
p38 MAPK signaling pathway	2.0	126.0	44.0	-0.116	0.016	1000.0	-1000.0	-0.062	-1000.0
Aurora B signaling	2.0	155.0	67.0	-0.112	0.028	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by HDAC Class II	1.0	113.0	75.0	-0.044	0.025	1000.0	-1000.0	-0.054	-1000.0
BARD1 signaling events	1.0	65.0	57.0	-0.012	0.053	1000.0	-1000.0	-0.069	-1000.0
Circadian rhythm pathway	1.0	40.0	22.0	-0.023	0.032	1000.0	-1000.0	-0.062	-1000.0
Aurora A signaling	1.0	107.0	60.0	-0.071	0.024	1000.0	-1000.0	-0.061	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.007	0.01	1000.0	-1000.0	-0.035	-1000.0
Insulin-mediated glucose transport	1.0	42.0	32.0	-0.056	0.027	1000.0	-1000.0	-0.054	-1000.0
PDGFR-alpha signaling pathway	1.0	47.0	44.0	-0.046	0.032	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	129.0	68.0	-0.056	0.033	1000.0	-1000.0	-0.069	-1000.0
ceramide signaling pathway	1.0	87.0	49.0	-0.047	0.028	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	1.0	147.0	104.0	-0.085	0.046	1000.0	-1000.0	-0.066	-1000.0
FoxO family signaling	1.0	71.0	64.0	-0.072	0.112	1000.0	-1000.0	-0.085	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	42.0	36.0	-0.015	0.019	1000.0	-1000.0	-0.066	-1000.0
Atypical NF-kappaB pathway	1.0	46.0	31.0	-0.027	0.028	1000.0	-1000.0	-0.048	-1000.0
Arf6 trafficking events	1.0	121.0	71.0	-0.056	0.034	1000.0	-1000.0	-0.061	-1000.0
VEGFR1 specific signals	1.0	70.0	56.0	-0.013	0.034	1000.0	-1000.0	-0.075	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.003	0.038	1000.0	-1000.0	-0.071	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.007	0.016	1000.0	-1000.0	-0.013	-1000.0
PLK1 signaling events	0.0	68.0	85.0	-0.008	0.025	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	0.0	16.0	53.0	-0.021	0.019	1000.0	-1000.0	-0.058	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.008	0.025	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.006	0.026	1000.0	-1000.0	-0.052	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.003	0.01	1000.0	-1000.0	-0.061	-1000.0
Total	1059	62425	7203	-18.6247476161	-1994.99964947	131000	-131000	-9.13920270026	-131000