rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(116), MDM2(2), MYC(6), PIK3CA(96), PIK3R1(10), POLR1A(10), POLR1B(4), POLR1C(3), RAC1(16), RB1(18), TBX2(4), TP53(426), TWIST1(1) 15420104 720 420 371 20 90 120 90 118 290 12 1.11e-15 <1.00e-15 <4.11e-14 2 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(16), CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG2(4), CDC25A(2), CDK4(5), CDKN1B(3), CDKN2A(116), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(10), CREB3L4(2), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), GADD45A(1), GBA2(9), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MNAT1(1), MYC(6), MYT1(12), NACA(25), PCNA(1), POLA2(2), POLE(11), POLE2(1), PRIM1(3), RB1(18), RBL1(11), RPA1(5), RPA2(1), TFDP1(3), TFDP2(1), TNXB(23), TP53(426), WEE1(1) 58754687 797 416 516 76 105 118 141 112 308 13 <1.00e-15 <1.00e-15 <4.11e-14 3 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(1), BAX(2), BTK(8), CAD(5), CASP10(3), CASP3(2), CASP8(61), CD7(2), CSNK1A1(1), DAXX(5), DEDD(1), DEDD2(5), DIABLO(2), EGFR(21), EPHB2(3), FADD(4), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MET(4), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR0B2(1), PFN1(1), PTPN13(13), RALBP1(5), RIPK1(2), ROCK1(19), SMPD1(2), TNFRSF6B(4), TP53(426), TPX2(5), TRAF2(2), TUFM(2) 55474647 698 416 462 67 113 99 130 104 239 13 <1.00e-15 <1.00e-15 <4.11e-14 4 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(40), DAXX(5), HRAS(32), PAX3(6), PML(4), RARA(4), RB1(18), SIRT1(2), SP100(8), TNFRSF1A(1), TNFRSF1B(2), TP53(426) 14483208 548 402 307 32 88 65 104 83 197 11 <1.00e-15 <1.00e-15 <4.11e-14 5 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(16), ATR(25), BRCA1(12), CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CDC34(4), CHEK1(1), CHEK2(5), EP300(39), GADD45A(1), MDM2(2), MYT1(12), PRKDC(28), RPS6KA1(10), TP53(426), WEE1(1), YWHAH(2), YWHAQ(3) 31890716 600 394 376 34 94 85 107 102 202 10 1.33e-15 <1.00e-15 <4.11e-14 6 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(16), ATR(25), BRCA1(12), BRCA2(22), CHEK1(1), CHEK2(5), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(9), RAD51(1), RAD9A(2), TP53(426), TREX1(4) 33493143 558 390 341 32 81 86 93 96 192 10 <1.00e-15 <1.00e-15 <4.11e-14 7 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(4), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(5), MYEF2(7), NFATC3(6), NR2C2(1), PAPPA(13), SHC1(3), TP53(426), TRAF6(3), ZAK(5) 38392565 599 388 379 50 100 85 119 92 193 10 <1.00e-15 <1.00e-15 <4.11e-14 8 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(5), IKBKB(12), JAK2(5), LIN7A(5), NFKB1(5), NFKBIA(1), RB1(18), RELA(2), TNFRSF1A(1), TNFRSF1B(2), TP53(426), USH1C(7), WT1(3) 13844325 501 384 283 28 78 57 85 77 194 10 <1.00e-15 <1.00e-15 <4.11e-14 9 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(12), RB1(18), TP53(426), WEE1(1), YWHAH(2) 13349006 491 381 274 14 79 59 75 75 193 10 <1.00e-15 <1.00e-15 <4.11e-14 10 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(20), AKT1(2), ATM(16), BAX(2), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(4), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(2), NQO1(3), TP53(426) 15825286 493 372 276 26 83 59 79 77 185 10 <1.00e-15 <1.00e-15 <4.11e-14 11 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(16), ATR(25), CDC25C(4), CHEK1(1), CHEK2(5), TP53(426), YWHAH(2) 12164049 479 367 262 14 76 61 71 81 180 10 <1.00e-15 <1.00e-15 <4.11e-14 12 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), TP53(426), WT1(3) 5374456 443 361 224 12 72 49 69 70 173 10 <1.00e-15 <1.00e-15 <4.11e-14 13 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(10), HLA-A(24), IL18(1), ITGB1(17), KLRC1(1), KLRC2(1), KLRC3(4), LAT(3), MAP2K1(5), PAK1(3), PIK3CA(96), PIK3R1(10), PTK2B(4), PTPN6(3), RAC1(16), SYK(8), VAV1(8) 14134507 214 169 141 17 23 70 27 48 46 0 3.70e-13 <1.00e-15 <4.11e-14 14 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(4), GH1(4), GHR(8), HRAS(32), IGF1(1), IGF1R(13), PIK3CA(96), PIK3R1(10), SHC1(3), SOD1(1), SOD2(1), SOD3(3) 10132708 178 146 94 12 19 70 38 42 9 0 6.64e-14 <1.00e-15 <4.11e-14 15 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(1), CD80(5), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3CA(96), PIK3R1(10), PTPN11(2) 9726595 135 123 73 8 2 63 14 39 17 0 2.43e-11 <1.00e-15 <4.11e-14 16 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(5), GADD45A(1), JUN(1), MAPK8(4), MDM2(2), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(2), TP53(426) 22691030 504 376 286 29 78 65 85 81 185 10 <1.00e-15 1.33e-15 4.79e-14 17 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(10), PXN(3), STAT1(7), TLN1(24), TP53(426) 20835201 530 387 313 33 85 75 86 87 187 10 <1.00e-15 1.55e-15 4.79e-14 18 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(4), CDK4(5), CDKN1B(3), CDKN2A(116), CFL1(2), E2F2(3), MDM2(2), PRB1(8), TP53(426) 6424705 569 373 291 16 77 58 79 79 264 12 <1.00e-15 1.55e-15 4.79e-14 19 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(4), CCNE1(5), CDK4(5), CDK6(2), CDKN1B(3), HRAS(32), MAPK1(9), NFKB1(5), NFKBIA(1), PAK1(3), PIK3CA(96), PIK3R1(10), RAC1(16), RAF1(3), RB1(18), RELA(2), TFDP1(3) 15389151 219 173 121 19 26 75 40 44 34 0 8.88e-14 1.55e-15 4.79e-14 20 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), CDKN2A(116), CDKN2C(1), RB1(18), RBL1(11), TFDP1(3) 12176555 182 163 121 18 8 20 22 18 112 2 4.16e-08 1.55e-15 4.79e-14 21 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(6), DNAJC3(2), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2), TP53(426) 7476252 450 367 233 14 76 50 66 70 178 10 <1.00e-15 1.78e-15 5.21e-14 22 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(32), MAPK1(9), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), NTRK1(3), PIK3CA(96), PIK3R1(10), PLCG1(8), RPS6KA1(10), SHC1(3) 14413023 205 164 114 14 27 72 42 47 17 0 <1.00e-15 1.89e-15 5.28e-14 23 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), FADD(4), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2) 28538961 588 399 357 32 95 79 95 90 217 12 <1.00e-15 2.00e-15 5.35e-14 24 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(12), ATM(16), ATR(25), BAI1(8), BAX(2), BID(3), CASP3(2), CASP8(61), CASP9(1), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(2), CDKN2A(116), CHEK1(1), CHEK2(5), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(8), IGF1(1), IGFBP3(1), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(6), PTEN(14), RCHY1(2), RFWD2(2), RRM2(1), RRM2B(1), SERPINE1(8), SESN1(3), SESN2(3), SESN3(3), SFN(7), SIAH1(5), STEAP3(4), THBS1(8), TNFRSF10B(1), TP53(426), TSC2(8), ZMAT3(2) 49796429 826 417 536 64 103 113 122 131 343 14 <1.00e-15 2.11e-15 5.41e-14 25 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(8), ATM(16), ATR(25), CCNA1(7), CCND1(4), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), CDKN2A(116), DHFR(3), GSK3B(3), HDAC1(1), RB1(18), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), TP53(426) 22944260 657 396 378 32 85 73 99 98 290 12 <1.00e-15 2.55e-15 6.29e-14 26 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(12), ATM(16), BAX(2), BCL2(1), CCND1(4), CCNE1(5), CDK4(5), GADD45A(1), MDM2(2), PCNA(1), RB1(18), TP53(426) 13779449 493 379 276 18 76 62 71 80 194 10 <1.00e-15 3.11e-15 7.37e-14 27 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IGF1(1), IGF1R(13), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(96), PIK3R1(10), PTPN11(2), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1) 18853105 216 173 130 12 22 71 49 46 27 1 <1.00e-15 3.66e-15 8.06e-14 28 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(2), BCL2L1(2), CASP9(1), CDC42(4), CHUK(6), ELK1(2), H2AFX(1), HRAS(32), MAP2K1(5), NFKB1(5), PIK3CA(96), PIK3R1(10), RAC1(16), RAF1(3), RALBP1(5), RALGDS(9), RELA(2), RHOA(10) 14514046 213 162 119 16 28 74 50 42 19 0 9.10e-15 3.66e-15 8.06e-14 29 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(32), KLK2(2), NTRK1(3), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), SHC1(3), SOS1(9) 11846864 172 145 88 13 16 68 38 40 10 0 3.68e-12 3.89e-15 8.25e-14 30 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(21), IGF1R(13), MYC(6), POLR2A(11), PRKCA(7), RB1(18), TEP1(16), TERF1(5), TERT(4), TNKS(8), TP53(426), XRCC5(4) 21499108 542 390 323 44 86 75 91 85 194 11 <1.00e-15 4.22e-15 8.66e-14 31 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(2), HRAS(32), IGF1R(13), IRS1(4), MAP2K1(5), MAPK1(9), PIK3CA(96), PIK3R1(10), RAF1(3), SHC1(3), SOS1(9), YWHAH(2) 14435703 190 151 99 14 26 71 40 41 12 0 3.52e-14 4.66e-15 9.12e-14 32 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(2), CASP8(61), CFL1(2), CFLAR(2) 2949686 68 62 56 6 6 13 8 9 30 2 6.60e-05 4.77e-15 9.12e-14 33 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(4), CCND1(4), CCNE1(5), CCNE2(4), CDK4(5), CDKN1B(3), CDKN2A(116), E2F2(3), E2F4(2), PRB1(8) 6829711 161 149 100 14 5 18 21 19 96 2 3.02e-08 5.22e-15 9.12e-14 34 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(96), PIK3R1(10), PLCB1(21), PLCG1(8), PRKCA(7), VAV1(8) 9755826 152 135 90 14 9 64 28 38 13 0 8.80e-10 5.22e-15 9.12e-14 35 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(12), BAD(2), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(2), BIRC3(2), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CHUK(6), FADD(4), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(12), IRF1(8), IRF2(8), IRF3(3), IRF4(5), IRF5(3), IRF6(6), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), PLEKHG5(6), PRF1(4), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2), TRAF3(6) 43759524 679 411 447 62 113 103 112 99 240 12 <1.00e-15 5.33e-15 9.12e-14 36 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(2), PIK3CA(96), PIK3R1(10), PLCG1(8), RAF1(3), SHC1(3), SOS1(9) 14516249 190 155 106 10 20 67 47 39 17 0 1.33e-15 5.33e-15 9.12e-14 37 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(2), CASP9(1), CHUK(6), GH1(4), GHR(8), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3CA(96), PIK3R1(10), RELA(2), YWHAH(2) 10744900 143 127 81 12 7 67 18 37 14 0 6.84e-10 5.55e-15 9.24e-14 38 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), INSR(3), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(96), PIK3R1(10), PTPN11(2), RAF1(3), RASA1(17), SHC1(3), SLC2A4(4), SOS1(9), SRF(1) 19385060 209 170 123 10 18 69 48 45 28 1 <1.00e-15 5.77e-15 9.36e-14 39 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CAPN1(3), CAPN2(6), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(8), FADD(4), FAS(5), FASLG(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(6), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2) 63595168 853 437 560 93 126 169 139 155 252 12 <1.00e-15 4.71e-14 7.44e-13 40 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(4), AKT3(6), ELK1(2), HRAS(32), MAP2K1(5), MAP2K2(6), NGFR(2), NTRK1(3), PIK3CA(96), PIK3CD(8), SHC1(3), SOS1(9) 12300008 178 148 94 18 24 64 39 44 7 0 3.90e-11 5.71e-13 8.79e-12 41 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), CDKN1B(3), ILK(4), ITGB1(17), MAPK1(9), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), PTK2(10), SHC1(3), SOS1(9) 14721142 185 153 115 16 19 70 25 41 30 0 2.78e-11 1.68e-12 2.52e-11 42 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(14), PIK3CA(96), PIK3R1(10), RAC1(16), WASL(2) 10169498 153 131 85 17 13 67 21 39 13 0 2.34e-07 7.28e-10 1.07e-08 43 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), THPO(1) 22794563 235 178 149 20 24 80 54 45 31 1 3.97e-14 7.45e-09 1.07e-07 44 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(22), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(12), HRAS(32), MAPK1(9), MAPK14(2), PIK3CA(96), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAC1(16), RPS6KA1(10), RPS6KA5(5), SOS1(9) 22165552 260 197 161 26 44 88 55 50 23 0 5.64e-14 1.33e-08 1.87e-07 45 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(3), CASP3(2), CASP8(61), CASP9(1), GZMB(2), JUN(1), PRF1(4) 9810864 99 85 87 8 10 16 12 21 38 2 1.49e-05 8.32e-08 1.14e-06 46 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(12), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3CA(96), PIK3R1(10), RELA(2), SYT1(8) 13656765 158 133 97 14 15 67 20 42 14 0 6.61e-10 2.61e-07 3.50e-06 47 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(5), FURIN(1), NOTCH1(95) 7141554 106 98 103 14 17 18 16 10 44 1 6.03e-05 4.24e-07 5.56e-06 48 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), MAPK1(9), PDK1(3), PIK3CA(96), PIK3CD(8), PTEN(14), PTK2B(4), RBL2(6), SHC1(3), SOS1(9) 15549505 170 143 102 18 22 66 23 43 16 0 4.40e-10 5.06e-07 6.49e-06 49 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(13), INPPL1(9), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), RPS6KB1(5) 15006074 173 139 111 19 12 74 21 39 27 0 1.79e-09 7.77e-06 9.77e-05 50 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(40), EP300(39), FYN(5), IL7(1), IL7R(6), JAK1(11), JAK3(6), LCK(5), NMI(6), PIK3CA(96), PIK3R1(10), PTK2B(4), STAT5A(3), STAT5B(5) 21261803 238 188 169 29 17 87 37 59 37 1 8.48e-12 8.44e-06 0.000104 51 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 26535800 260 194 174 28 27 84 62 49 37 1 1.67e-12 9.66e-06 0.000117 52 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(22), ARHGEF1(9), F2(3), F2R(4), F2RL3(3), GNA12(2), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3CA(96), PIK3R1(10), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2B(4), ROCK1(19) 19689317 220 176 156 27 23 79 46 53 19 0 1.59e-10 2.78e-05 0.000329 53 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIK(1), BIRC2(2), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), DIABLO(2) 10208169 100 84 88 9 11 21 13 15 38 2 1.31e-05 6.83e-05 0.000794 54 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NFKB1(5), PIK3CA(96), PIK3R1(10), RB1(18), RELA(2), SP1(3) 14760197 170 149 102 23 19 63 23 35 30 0 1.79e-06 0.000330 0.00376 55 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(4), GHR(8), HRAS(32), INSR(3), IRS1(4), JAK2(5), MAP2K1(5), MAPK1(9), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5) 25163672 233 180 142 23 31 85 57 44 16 0 2.09e-14 0.000544 0.00609 56 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(6), JUN(1), KEAP1(24), MAPK1(9), MAPK14(2), MAPK8(4), NFE2L2(27), PRKCA(7) 6773267 81 72 64 11 16 16 26 14 9 0 0.000432 0.00216 0.0238 57 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(2), BTK(8), CDKN2A(116), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(10), PDK1(3), PIK3CA(96), PPP1R13B(2), PTEN(14), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 27402412 360 258 238 47 24 92 58 66 117 3 4.42e-12 0.00227 0.0246 58 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3CA(96), PIK3R1(10), RAF1(3), SOS1(9), STAT1(7), STAT5A(3), STAT5B(5) 21419823 208 160 122 26 18 82 49 41 18 0 6.52e-10 0.00610 0.0648 59 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(6), BIRC3(2), CASP8(61), FADD(4), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 6409161 81 70 69 11 9 13 14 12 31 2 0.000431 0.00637 0.0665 60 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(13), HRAS(32), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(4), MAPK1(9), MAPK8(4), MET(4), PAK1(3), PIK3CA(96), PIK3R1(10), PTEN(14), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAF1(3), RAP1B(3), RASA1(17), SOS1(9), STAT3(6) 33522430 316 226 220 34 41 83 75 69 47 1 1.29e-13 0.0133 0.135 61 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(5), CDC34(4), CUL1(11), FBXW7(34), RB1(18), TFDP1(3) 6256728 75 66 66 11 7 14 17 8 28 1 0.0158 0.0133 0.135 62 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(2), CHRNB1(1), CHRNG(9), MUSK(7), PIK3CA(96), PIK3R1(10), PTK2(10), PTK2B(4), TERT(4), YWHAH(2) 12473639 147 134 86 24 10 65 19 39 14 0 9.17e-07 0.0157 0.156 63 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), RPS6KB1(5), TSC1(5), TSC2(8) 21047491 197 158 135 23 9 78 31 42 37 0 9.97e-09 0.0367 0.359 64 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(9), EGFR(21), ELK1(2), FOS(6), HRAS(32), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 28485311 276 207 190 33 27 87 65 57 38 2 1.25e-11 0.105 1.000 65 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), GHR(8), IRS1(4), MAPK1(9), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PRKCA(7), PTEN(14), RPS6KB1(5) 21442415 208 165 139 27 13 82 31 46 36 0 3.79e-08 0.116 1.000 66 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(8), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(13), HIF1A(3), HRAS(32), KDR(13), NOS3(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PXN(3), SHC1(3) 25828702 260 191 176 30 35 91 57 53 24 0 4.89e-12 0.123 1.000 67 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(16), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND2(2), CCNE1(5), CCNE2(4), CDAN1(7), CDC14A(3), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CDKN2A(116), CHEK1(1), CHEK2(5), DTX4(5), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), EP300(39), ESPL1(10), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), HDAC8(2), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(4), RB1(18), RBL1(11), SKP2(4), SMAD4(15), TBC1D8(4), TFDP1(3), TGFB1(2), TP53(426), WEE1(1) 83552232 904 436 618 112 121 134 158 139 340 12 <1.00e-15 0.136 1.000 68 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(6), HRAS(32), JUN(1), MAP2K1(5), MAPK1(9), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RAF1(3), RELA(2) 11837893 101 90 68 15 22 17 42 11 9 0 0.000153 0.292 1.000 69 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 386575 2 2 2 0 0 0 0 0 2 0 0.660 0.300 1.000 70 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(22), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(8), MAPK1(9), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLCB1(21), PRKCA(7), PTK2(10), RAC1(16), SMPD1(2) 20861205 229 182 152 31 30 83 44 50 22 0 2.76e-10 0.329 1.000 71 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(12), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP7(3), CASP8(61), CASP9(1), GZMB(2), PRF1(4), SCAP(9), SREBF1(5), SREBF2(5) 13843945 111 92 99 13 14 19 18 19 39 2 3.58e-05 0.357 1.000 72 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(2), CXCL12(6), CXCR4(2), GNAI1(2), GNB1(3), HRAS(32), MAP2K1(5), MAPK1(9), NFKB1(5), PIK3C2G(13), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PTK2B(4), PXN(3), RAF1(3), RELA(2) 21054454 225 173 133 30 31 73 50 48 23 0 4.05e-09 0.451 1.000 73 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(1), EGR1(4), HRAS(32), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), NGFR(2), RAF1(3) 6215510 67 59 37 12 22 8 26 5 6 0 0.00216 0.460 1.000 74 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 4644911 24 22 24 2 5 7 5 5 2 0 0.0310 0.501 1.000 75 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(32), PTK2B(4), SHC1(3), SOS1(9) 6702458 49 44 26 7 14 5 22 6 2 0 0.0219 0.556 1.000 76 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 549130 2 2 2 1 1 0 0 1 0 0 0.796 0.574 1.000 77 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PIK3CA(96), PIK3CD(8), PIK3R1(10), SYT1(8), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 25656897 206 164 138 29 30 73 33 42 28 0 5.58e-10 0.591 1.000 78 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(22), AKT1(2), BAD(2), BAX(2), BCL2(1), BCL2L1(2), CSF2RB(8), IGF1(1), IGF1R(13), IL3(1), IL3RA(6), KIT(11), KITLG(1), PIK3CA(96), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), YWHAH(2) 16694904 196 155 134 31 18 81 31 47 19 0 2.98e-08 0.591 1.000 79 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(6) 1383171 9 9 9 2 1 3 2 2 1 0 0.347 0.623 1.000 80 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(7) 1537915 13 13 13 3 0 4 5 3 1 0 0.369 0.674 1.000 81 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(2), RAB27A(1), RAB3A(2), RAB4A(1), RAB5A(3) 3208378 14 14 14 1 5 4 2 2 1 0 0.0336 0.685 1.000 82 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(4), UXS1(2) 2921501 11 11 11 0 0 1 5 4 1 0 0.104 0.695 1.000 83 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(4) 1256585 6 6 6 2 1 3 2 0 0 0 0.649 0.717 1.000 84 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(10), BCMO1(3), RDH5(1) 2966657 15 15 15 3 2 1 6 2 4 0 0.357 0.778 1.000 85 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(4), UGP2(2), UXS1(2) 3720453 13 13 13 0 0 1 7 4 1 0 0.0736 0.792 1.000 86 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(5), APC(27), AXIN1(11), BTRC(1), CTNNB1(6), DLL1(5), DVL1(7), FZD1(6), GSK3B(3), NOTCH1(95), WNT1(2) 16419280 168 130 164 28 27 33 30 22 54 2 0.000149 0.802 1.000 87 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2) 1800404 7 7 6 2 0 1 0 3 3 0 0.747 0.810 1.000 88 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(18), SP1(3), SP3(3) 5049097 26 26 26 9 0 2 5 4 15 0 0.839 0.811 1.000 89 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IL6(2), IL6R(5), IL6ST(4), JAK1(11), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT3(6) 18102118 111 97 88 13 20 15 44 19 13 0 4.14e-05 0.816 1.000 90 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(1), RXRA(5) 4399391 16 16 16 1 2 4 6 2 2 0 0.0307 0.837 1.000 91 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 1694316 7 7 7 2 1 3 2 0 1 0 0.481 0.845 1.000 92 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CHEK1(1), NEK1(9), WEE1(1) 5221484 17 17 17 1 4 3 6 1 3 0 0.124 0.864 1.000 93 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15) 9561208 87 71 86 14 11 24 27 13 12 0 0.00556 0.880 1.000 94 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(1), GRIA2(16), JUND(1), PPP1R1B(2) 2839623 23 22 23 6 4 6 11 2 0 0 0.219 0.892 1.000 95 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(12), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), GZMB(2), LMNA(1), LMNB1(1), LMNB2(8), PRF1(4) 14688009 115 92 103 15 14 21 17 22 39 2 0.000154 0.894 1.000 96 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(27), CDH1(5), CREBBP(40), EP300(39), MAP2K1(5), MAP3K7(8), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25) 19514612 160 125 141 23 20 32 36 33 38 1 0.000230 0.905 1.000 97 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(5), SNCA(1), SNCAIP(3), UBE2L3(2), UBE2L6(2) 4889898 23 21 23 4 4 5 4 7 3 0 0.155 0.912 1.000 98 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(2), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), HRAS(32), IL2RA(2), IL2RB(3), IRS1(4), JAK1(11), JAK3(6), MAPK1(9), MYC(6), NMI(6), PIK3CA(96), PIK3R1(10), PTPN6(3), RAF1(3), RPS6KB1(5), SHC1(3), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 27493128 247 182 154 32 31 91 53 49 23 0 2.77e-12 0.921 1.000 99 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(5), HRAS(32), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PIK3CA(96), PIK3R1(10), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(5), RAC1(16), RAF1(3), RASA1(17), RELA(2), SHC1(3), SOS1(9), SYT1(8), VAV1(8), ZAP70(2) 36398434 315 219 222 40 47 90 73 60 44 1 2.59e-12 0.940 1.000 100 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(6), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2) 2305423 12 12 11 4 0 4 4 0 4 0 0.598 0.953 1.000 101 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1160551 1 1 1 0 0 0 0 1 0 0 0.757 0.955 1.000 102 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(10), DIAPH1(7), FYN(5), GSN(5), HRAS(32), ITGA1(4), ITGB1(17), MAP2K1(5), MAPK1(9), MYLK(8), PFN1(1), PIK3CA(96), PIK3R1(10), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), TLN1(24) 28396862 271 195 179 37 37 82 60 62 30 0 2.93e-09 0.956 1.000 103 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PAK2(8), PIK3CA(96), PIK3R1(10), PLA2G4A(3), PLCG1(8), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 32740288 296 211 205 40 46 85 70 62 32 1 2.20e-10 0.957 1.000 104 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(40), EP300(39), ESR1(6), MAPK1(9), PELP1(2) 11210168 96 86 81 16 17 18 21 17 22 1 0.00195 0.958 1.000 105 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), HRAS(32), ITGA1(4), ITGB1(17), MAP2K1(5), MAPK1(9), PLA2G4A(3), PLCB1(21), PRKCA(7), PTGS1(7), PTK2(10), RAF1(3), SYK(8), TBXAS1(5) 18535678 146 118 114 22 29 22 51 23 21 0 8.19e-05 0.961 1.000 106 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(1), IL12B(4), IL18(1), IL2(2) 2267286 12 12 12 4 1 2 2 4 3 0 0.769 0.963 1.000 107 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(4), PRKCA(7), TGM2(4) 3760452 18 18 18 4 2 6 5 3 2 0 0.114 0.965 1.000 108 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(2), EPO(2), EPOR(2), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(8), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 16317743 100 87 77 13 20 21 42 7 10 0 8.25e-05 0.967 1.000 109 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(40), EP300(39), LPL(4), NCOA1(7), NCOA2(8), PPARG(1), RXRA(5) 14060638 104 87 96 15 12 23 26 22 20 1 0.000851 0.971 1.000 110 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(5), CES1(7), ESD(3) 4600242 20 19 20 3 2 9 7 0 2 0 0.0470 0.972 1.000 111 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(5) 3898124 16 15 16 3 4 3 6 2 1 0 0.151 0.973 1.000 112 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 860420 1 1 1 1 0 0 1 0 0 0 0.944 0.975 1.000 113 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(5), GAD1(4), GAD2(7), GGT1(4) 4376205 24 24 24 5 4 7 6 2 5 0 0.117 0.980 1.000 114 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2) 6634572 26 24 26 4 1 5 8 7 5 0 0.138 0.986 1.000 115 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4) 1300338 4 4 4 3 0 1 2 0 1 0 0.872 0.991 1.000 116 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(6), FOSL1(3), FOSL2(10), IFNAR1(3), IFNAR2(3), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3) 8440356 43 40 43 8 6 9 10 9 9 0 0.185 0.991 1.000 117 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 3683426 12 10 12 2 0 4 3 3 2 0 0.269 0.991 1.000 118 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(4), CHST12(5), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 7044363 40 37 40 7 10 7 11 8 4 0 0.0562 0.992 1.000 119 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1) 6032901 24 21 24 4 7 3 7 2 5 0 0.150 0.993 1.000 120 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(22), GNAS(12), GNB1(3), PRKACA(4), PRKAR1A(3) 5046187 44 37 43 8 15 7 13 6 3 0 0.0443 0.993 1.000 121 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 4111521 14 14 14 3 2 3 4 4 1 0 0.357 0.994 1.000 122 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(4) 4058542 23 21 23 6 2 1 11 1 8 0 0.437 0.994 1.000 123 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(2), HMGCL(1), OXCT1(2) 2569006 5 5 5 2 1 0 1 1 2 0 0.781 0.994 1.000 124 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(3), TAT(1) 1997140 5 5 5 2 0 0 3 1 1 0 0.768 0.996 1.000 125 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(3), AASS(3), KARS(3) 3583040 12 12 12 3 1 1 2 3 5 0 0.515 0.996 1.000 126 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4) 4282569 14 13 14 4 1 4 2 3 4 0 0.561 0.997 1.000 127 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(4), AKT3(6), BRD4(9), CAP1(6), CBL(3), CDC42(4), CDKN2A(116), F2RL2(2), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), LNPEP(5), MAPK1(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PTEN(14), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(7), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 45306745 452 288 322 64 52 112 74 78 134 2 2.16e-14 0.998 1.000 128 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(1), SPCS1(2), SPCS3(1) 2321334 6 6 6 4 0 2 1 0 3 0 0.848 0.998 1.000 129 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(3), STX1A(6) 2472973 9 9 9 3 5 0 3 1 0 0 0.647 0.999 1.000 130 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1) 5938441 17 16 17 3 2 4 5 4 2 0 0.219 0.999 1.000 131 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4) 6158075 34 32 34 9 5 8 12 6 3 0 0.286 0.999 1.000 132 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2) 2757273 18 14 18 6 1 8 5 2 2 0 0.389 0.999 1.000 133 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(6), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(5) 4142702 22 21 21 6 4 6 6 2 4 0 0.296 0.999 1.000 134 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(1), CD80(5), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1) 3017930 15 15 14 5 0 4 4 4 3 0 0.664 0.999 1.000 135 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(5), SEC61A2(4), SRP54(2), SRP68(4), SRP72(1), SRPR(2) 5730942 18 17 18 3 2 9 6 1 0 0 0.145 0.999 1.000 136 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1) 3251066 9 9 9 3 2 5 1 1 0 0 0.406 0.999 1.000 137 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15) 13331121 102 83 101 19 13 32 30 14 13 0 0.00403 0.999 1.000 138 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(8), FOS(6), HRAS(32), IL3(1), IL3RA(6), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 13449770 89 76 66 15 16 20 35 11 7 0 0.00174 1.000 1.000 139 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(5), CDC34(4), CUL1(11), RB1(18), SKP2(4), TFDP1(3) 6468191 52 45 52 13 4 12 13 5 18 0 0.217 1.000 1.000 140 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(1), CREBBP(40), EP300(39), NCOA3(9), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RARA(4), RXRA(5) 15705952 119 99 111 22 20 29 23 20 26 1 0.00244 1.000 1.000 141 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(6), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2) 4052954 19 19 18 6 1 5 8 2 3 0 0.535 1.000 1.000 142 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(6), CD3D(1), CD4(1), CD58(2), CD8A(2), IL3(1), IL6(2), KITLG(1) 4699278 17 16 17 6 2 2 3 4 6 0 0.695 1.000 1.000 143 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(4), GLUD2(10) 3468502 17 17 17 6 4 2 4 3 4 0 0.686 1.000 1.000 144 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(9), EGFR(21), HRAS(32), MAP2K1(5), MAPK1(9), PTPRB(24), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2) 18973452 145 127 113 26 29 18 49 24 23 2 0.00366 1.000 1.000 145 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(6), CTH(3), MUT(5) 3728828 18 17 18 5 2 6 4 3 3 0 0.473 1.000 1.000 146 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(2), IDI1(1) 2430488 7 7 7 3 2 4 1 0 0 0 0.550 1.000 1.000 147 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(8) 3576674 20 18 20 6 2 3 10 1 4 0 0.520 1.000 1.000 148 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(1) 3047233 15 14 15 5 2 3 5 2 3 0 0.600 1.000 1.000 149 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(22), CAP1(6), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(12), GNB1(3), HRAS(32), MAPK1(9), MYT1(12), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10) 15647677 136 108 105 22 42 23 42 17 12 0 6.57e-05 1.000 1.000 150 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(5), JAK1(11), JAK2(5), STAT1(7) 6222329 34 30 33 9 2 9 9 5 9 0 0.242 1.000 1.000 151 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3) 7710747 36 34 36 8 6 7 13 4 6 0 0.102 1.000 1.000 152 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(22), CREM(3), FHL5(5), FSHB(2), FSHR(12), GNAS(12), XPO1(6) 7305896 62 53 61 12 14 12 19 14 3 0 0.0687 1.000 1.000 153 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(7), SDHB(1), SDHC(1), UQCRC1(1) 5030336 17 17 16 4 1 5 6 4 1 0 0.336 1.000 1.000 154 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(3), CD3D(1), CD4(1) 2438429 5 5 5 3 0 0 1 3 1 0 0.904 1.000 1.000 155 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(3), HTR2C(3), PLCB1(21), TUB(3) 5432569 30 30 29 8 7 5 12 5 1 0 0.293 1.000 1.000 156 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(2), BAX(2), BCL2(1), CASP8(61), FADD(4), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), SMPD1(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 15649806 120 99 101 24 23 15 27 15 38 2 0.00889 1.000 1.000 157 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IL2(2), IL2RA(2), IL2RB(3), JAK1(11), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 17713789 117 98 94 21 18 21 46 14 18 0 0.000914 1.000 1.000 158 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1) 6350763 18 16 18 4 1 3 8 4 2 0 0.416 1.000 1.000 159 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDKN1B(3), CKS1B(4), CUL1(11), NEDD8(2), RB1(18), RBX1(3), SKP2(4), TFDP1(3), UBE2M(2) 6508770 55 51 55 14 4 13 12 6 20 0 0.202 1.000 1.000 160 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(6), FYN(5), JUN(1), MAPK14(2), THBS1(8) 5637356 26 24 26 7 3 7 5 7 4 0 0.239 1.000 1.000 161 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(9), EGFR(21), FOS(6), HRAS(32), JUN(1), MYC(6), NFKB1(5), PLCG1(8), PRKCA(7), RELA(2) 15638469 119 102 94 26 19 25 49 17 8 1 0.0121 1.000 1.000 162 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(3) 5282395 17 17 17 5 1 1 3 6 6 0 0.603 1.000 1.000 163 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3) 8183514 37 35 37 9 6 7 14 4 6 0 0.137 1.000 1.000 164 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15), MASP1(9), MASP2(5), MBL2(2) 16224110 118 92 116 23 16 34 31 20 17 0 0.00340 1.000 1.000 165 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3) 5283313 15 14 15 3 3 5 5 1 1 0 0.283 1.000 1.000 166 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3) 7766709 32 31 32 7 7 10 8 3 4 0 0.0943 1.000 1.000 167 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(22), NRG2(6), NRG3(17), PRKCA(7) 6834830 57 52 57 15 4 9 22 12 10 0 0.371 1.000 1.000 168 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(6), CREBBP(40), EP300(39), FADD(4), HDAC3(3), IKBKB(12), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 17062244 121 108 113 23 17 25 31 23 24 1 0.00366 1.000 1.000 169 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(6), ST6GALNAC2(3), ST8SIA1(3) 4298913 20 19 20 7 4 4 5 2 5 0 0.426 1.000 1.000 170 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(2) 4604224 22 22 22 8 3 2 11 1 5 0 0.649 1.000 1.000 171 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(12), WEE1(1), YWHAH(2) 10453443 42 37 42 7 7 9 11 8 7 0 0.120 1.000 1.000 172 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT2(2), FUT9(11), GCNT2(7), ST8SIA1(3) 4694960 26 25 25 9 4 6 13 2 1 0 0.464 1.000 1.000 173 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(2), GGT1(4), SHMT1(1), SHMT2(2) 3159906 9 8 9 4 3 0 4 1 1 0 0.730 1.000 1.000 174 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6) 6560593 22 22 22 5 6 5 3 5 3 0 0.322 1.000 1.000 175 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(2), BLNK(5), ELK1(2), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK1(9), MAPK8IP3(8), PAPPA(13), RAC1(16), RPS6KA1(10), RPS6KA3(4), SHC1(3), SOS1(9), SYK(8), VAV1(8), VAV2(4), VAV3(4) 24385135 164 128 127 27 45 22 50 21 26 0 0.000114 1.000 1.000 176 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(4), OAT(1), PRODH(1) 4210897 8 8 8 3 0 2 1 3 2 0 0.659 1.000 1.000 177 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 10663831 47 41 47 9 11 11 13 6 6 0 0.0430 1.000 1.000 178 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 179 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 180 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(10), PDXK(1), PSAT1(1) 3686452 12 10 12 5 1 2 1 6 2 0 0.766 1.000 1.000 181 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(3), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1) 6763942 22 19 22 5 2 8 9 1 2 0 0.223 1.000 1.000 182 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(40), GZMA(2), GZMB(2), HMGB2(2), PRF1(4), SET(1) 8072642 53 44 52 13 10 8 13 11 10 1 0.145 1.000 1.000 183 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(10), CD3D(1), GZMB(2), HLA-A(24), ICAM1(6), ITGAL(7), ITGB2(4), PRF1(4) 6654400 58 49 54 16 6 7 8 8 29 0 0.234 1.000 1.000 184 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(11), COPS5(2), CREB1(1), EDN1(1), EP300(39), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(4), P4HB(1) 12917805 74 72 67 15 11 20 14 16 13 0 0.0254 1.000 1.000 185 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9) 7011957 32 29 32 9 6 8 10 6 2 0 0.240 1.000 1.000 186 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(5), TAX1BP3(1), UBE2D2(1), UBE2D3(1), UBE2E1(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(2), UBE2S(1), UBE3A(6) 8012959 29 27 29 8 4 11 8 0 6 0 0.326 1.000 1.000 187 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1B(4), BMPR2(6) 4760347 15 15 15 6 3 4 4 1 3 0 0.729 1.000 1.000 188 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(12), BAD(2), BAK1(1), BAX(2), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(7) 8316255 33 31 33 8 7 9 6 5 6 0 0.341 1.000 1.000 189 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1) 6441487 24 21 24 6 1 4 10 7 2 0 0.383 1.000 1.000 190 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TGFBR3(5), TOB2(3) 8033948 52 47 43 13 6 12 8 13 13 0 0.199 1.000 1.000 191 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(5), ITPKB(5) 4610024 11 9 11 4 1 3 4 1 2 0 0.609 1.000 1.000 192 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(16), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), MYOD1(2), YWHAH(2) 5857390 49 43 49 14 7 9 14 12 7 0 0.320 1.000 1.000 193 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(1), RANBP2(14), RANGAP1(1) 6414010 18 18 18 9 3 4 5 1 5 0 0.941 1.000 1.000 194 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C6(25), C7(12), C8A(8), C8B(9), C9(15), MASP1(9) 15837913 120 95 118 26 16 33 35 19 17 0 0.0129 1.000 1.000 195 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(2) 4542113 23 21 22 9 4 7 8 2 2 0 0.333 1.000 1.000 196 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6) 9796477 37 32 37 8 1 8 14 10 4 0 0.229 1.000 1.000 197 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(2), MDH1(1), ME1(2), PC(14), PDHA1(4) 7057566 27 27 27 8 4 7 6 5 5 0 0.331 1.000 1.000 198 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(2), CCL2(2), CXCL12(6), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(8), PRKCA(7), PTK2B(4), SYT1(8) 10487659 55 49 55 13 8 9 21 13 4 0 0.105 1.000 1.000 199 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NFS1(1), PHPT1(1), TPK1(3) 4868352 16 14 16 5 4 2 5 3 2 0 0.699 1.000 1.000 200 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), CDKN2A(116), FLOT1(2), FLOT2(4), GAB1(5), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PIK3CA(96), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(15), PTEN(14), PTPRC(19), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SAG(1), SYK(8), TEC(2), VAV1(8) 41848056 420 275 297 71 35 110 62 79 131 3 1.39e-11 1.000 1.000 201 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(4), JAK1(11), JAK2(5), PLA2G2A(2), PTPRU(9), REG1A(13), STAT1(7) 8690684 54 48 53 14 8 16 13 7 10 0 0.108 1.000 1.000 202 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(10), CREB1(1), CREB3(1), CREB5(8), MAPK1(9), RAF1(3), SNX13(2) 8458472 35 27 28 9 9 5 8 6 7 0 0.324 1.000 1.000 203 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(11), EPHB1(16), FYN(5), ITGA1(4), ITGB1(17), L1CAM(10), LYN(8), RAP1B(3), SELP(15) 12007305 93 66 91 20 13 17 25 18 20 0 0.0671 1.000 1.000 204 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(2), IL6(2), LDLR(6), LPL(4) 4042609 16 16 15 7 2 5 6 2 1 0 0.708 1.000 1.000 205 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8) 9615390 56 49 54 14 4 10 18 8 16 0 0.215 1.000 1.000 206 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(8), ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(25), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(4), CDC26(1), CDC27(8), CDC6(2), CDC7(1), CDK4(5), CDK6(2), CDKN1B(3), CDKN2A(116), CDKN2C(1), CHEK1(1), CHEK2(5), CREBBP(40), CUL1(11), DBF4(3), E2F2(3), E2F3(3), EP300(39), ESPL1(10), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(18), RBL1(11), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMAD4(15), SMC1A(3), SMC1B(7), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), TP53(426), WEE1(1), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 103396057 1007 440 720 140 126 162 183 168 355 13 <1.00e-15 1.000 1.000 207 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(3), GGT1(4), SHMT1(1), SHMT2(2) 4189992 11 11 11 5 5 2 2 1 1 0 0.639 1.000 1.000 208 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(2), PRKACB(3), PRKACG(3), PRKAR2B(3) 7645574 27 25 27 8 5 10 6 3 3 0 0.393 1.000 1.000 209 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(27), AXIN1(11), CCND1(4), CD14(1), CTNNB1(6), DVL1(7), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(8), LEF1(6), LY96(2), NFKB1(5), PDPK1(4), PIK3CA(96), PIK3R1(10), RELA(2), TIRAP(1), TLR4(16), TOLLIP(2), WNT1(2) 23476723 228 168 165 42 20 89 39 49 30 1 2.13e-06 1.000 1.000 210 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(6), ACTN2(11), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(17), ITGB3(8), PTK2(10), PXN(3), RAC1(16), SPTAN1(24), TLN1(24) 21715720 134 105 126 23 26 23 46 23 16 0 0.000746 1.000 1.000 211 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(2), IL1B(1), MST1(7), MST1R(8) 4955041 20 19 20 9 4 6 8 0 2 0 0.612 1.000 1.000 212 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(6), BIRC2(2), BIRC3(2), CASP3(2), CASP8(61), CFLAR(2), FADD(4), JUN(1), MAP2K4(2), MAP3K3(3), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR2C2(1), RALBP1(5), RIPK1(2), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 20816367 129 103 116 24 20 28 24 16 39 2 0.000808 1.000 1.000 213 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(2), OXCT2(1) 5469959 13 12 13 8 3 2 2 4 2 0 0.925 1.000 1.000 214 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(8), GLI2(15), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3) 12661824 70 62 69 17 13 17 24 8 8 0 0.0678 1.000 1.000 215 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(4) 6989177 25 24 25 8 6 7 6 2 4 0 0.397 1.000 1.000 216 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(4), IRS2(6), JAK1(11), JAK3(6), MAP4K1(4), MAPK1(9), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PPP1R13B(2), RAF1(3), SHC1(3), SOCS1(1), SOS1(9), SOS2(11), STAT6(5) 27851582 219 166 151 37 28 80 38 54 19 0 1.12e-07 1.000 1.000 217 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(5), ST3GAL4(1) 5501975 18 17 18 7 5 2 7 2 2 0 0.694 1.000 1.000 218 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(4), MPST(2) 5208192 19 17 19 7 4 1 11 2 1 0 0.707 1.000 1.000 219 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST7(2), CHSY1(3), DSE(2), UST(3), XYLT1(10), XYLT2(3) 10680334 56 51 56 12 14 5 19 11 7 0 0.0687 1.000 1.000 220 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(12), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), FADD(4), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2) 25457278 155 119 143 26 22 31 30 21 49 2 0.000112 1.000 1.000 221 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(12), GNB1(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7) 7309401 40 35 40 10 14 9 9 4 4 0 0.184 1.000 1.000 222 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAPN2(6), CAPNS1(2), CAPNS2(2), EP300(39), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(10), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(8) 18568573 117 100 109 27 18 27 28 26 18 0 0.0125 1.000 1.000 223 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1) 5573878 15 15 15 7 2 2 6 4 1 0 0.881 1.000 1.000 224 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), IMPA2(4), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3) 8868988 40 38 40 10 9 11 10 3 7 0 0.0806 1.000 1.000 225 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(4) 6469482 24 24 24 9 4 3 6 8 3 0 0.624 1.000 1.000 226 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(13), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), MYOD1(2), NFATC1(10), NFATC2(15), PIK3CA(96), PIK3R1(10), PPP3CA(2), PPP3CB(1), SYT1(8), YWHAH(2) 26534412 227 170 166 45 23 82 39 61 22 0 1.48e-06 1.000 1.000 227 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(2), CAMKK2(6), CREB1(1), SYT1(8) 8786689 37 37 37 10 5 7 13 8 4 0 0.366 1.000 1.000 228 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB3(1), CREB5(8), CREBBP(40), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), NTRK1(3), OPN1LW(3), PIK3C2G(13), PIK3CA(96), PIK3CD(8), PIK3R1(10), PTPN11(2), RPS6KA3(4), SHC1(3), TH(3) 39150078 292 208 222 51 37 90 57 64 43 1 8.55e-08 1.000 1.000 229 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA3(2), ANXA4(2), ANXA6(7), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(4), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 15681651 80 68 79 20 18 13 17 13 18 1 0.0720 1.000 1.000 230 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(5), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(4) 5738999 15 15 15 8 1 3 5 5 1 0 0.913 1.000 1.000 231 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(5), HDAC5(3), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(4), SYT1(8), YWHAH(2) 15410081 72 61 71 17 5 19 24 17 7 0 0.0656 1.000 1.000 232 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(9), EGFR(21), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(24), RARA(4), RXRA(5), THRA(7), THRB(1) 13131412 84 69 84 22 13 14 24 18 14 1 0.139 1.000 1.000 233 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(14), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(21), ELK1(2), HRAS(32), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), PAK1(3), PRKCA(7), PTK2(10), PTK2B(4), RAC1(16), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 25435181 200 148 163 38 40 36 67 39 18 0 0.000339 1.000 1.000 234 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 11404505 49 45 49 13 10 13 11 8 7 0 0.143 1.000 1.000 235 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(5), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(1), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 11454795 52 49 52 14 10 10 15 5 12 0 0.0625 1.000 1.000 236 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(8), FYN(5), LRP8(4), RELN(53), VLDLR(5) 10640095 79 65 79 23 14 16 19 16 14 0 0.233 1.000 1.000 237 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(2), DDX20(4), E2F4(2), ETS1(4), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), HRAS(32), JUN(1), NCOR2(24), RBL1(11), RBL2(6), SIN3A(6), SIN3B(11) 19785971 124 93 101 29 23 30 41 17 13 0 0.00834 1.000 1.000 238 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(5), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), RAC1(16), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 29084167 193 146 163 34 43 32 61 31 25 1 8.75e-05 1.000 1.000 239 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(5), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(4) 8140743 38 34 38 11 5 7 9 12 5 0 0.513 1.000 1.000 240 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F2(3), F2R(4), F3(2), F5(20), F7(3), FGA(10), FGB(4), FGG(6), PROC(2), PROS1(9), SERPINC1(4), TFPI(2) 12450168 73 58 73 19 6 23 21 13 10 0 0.158 1.000 1.000 241 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(6), CREBBP(40), DUSP1(2), EP300(39), IKBKB(12), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K7(8), MAPK11(4), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TGFBR2(25), TLR2(3) 22592775 163 134 145 31 23 33 36 30 40 1 0.00153 1.000 1.000 242 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(21), ELK1(2), GNAS(12), GNB1(3), HRAS(32), IGF1R(13), ITGB1(17), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MKNK1(1), MKNK2(3), MYC(6), NGFR(2), PDGFRA(14), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(3), SOS1(9), STAT3(6) 25134713 189 140 156 32 50 32 66 22 19 0 3.32e-05 1.000 1.000 243 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(1), FARSB(7), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7), YARS2(4) 6612485 35 32 35 10 2 11 12 5 5 0 0.260 1.000 1.000 244 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4) 7051136 31 30 31 10 7 9 5 4 6 0 0.355 1.000 1.000 245 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6) 10251772 47 40 47 11 3 9 18 6 11 0 0.193 1.000 1.000 246 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB3(1), CREB5(8), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5) 21758164 104 86 96 22 20 25 25 15 19 0 0.0149 1.000 1.000 247 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL12A(1), IL12B(4), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4) 7559330 36 34 36 12 7 9 10 6 4 0 0.460 1.000 1.000 248 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(11), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(9), REG1A(13), SOAT1(5) 10403694 55 51 55 15 10 10 17 9 9 0 0.246 1.000 1.000 249 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(6), MBTPS1(10), MBTPS2(4), SCAP(9), SREBF1(5), SREBF2(5) 9048536 42 40 41 13 6 8 13 10 5 0 0.439 1.000 1.000 250 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(40), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), HRAS(32), IGF1(1), LIF(2), MAP2K1(5), MAPK1(9), MAPK14(2), MAPK8(4), MEF2C(16), MYH2(28), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKX2-5(1), NPPA(3), PIK3CA(96), PIK3R1(10), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(5), SYT1(8) 38646036 355 230 263 68 51 107 88 67 41 1 2.04e-08 1.000 1.000 251 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(5), JAK1(11), JAK2(5), JAK3(6), PIAS3(4), PTPRU(9), REG1A(13), STAT3(6) 11553078 62 58 62 17 11 11 20 12 8 0 0.171 1.000 1.000 252 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(27), AXIN1(11), CREBBP(40), CTNNB1(6), DVL1(7), EP300(39), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(6), PITX2(2), TRRAP(22), WNT1(2) 25263108 174 123 165 32 28 39 39 34 32 2 0.000135 1.000 1.000 253 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(5), JAK3(6), MAPK1(9), STAT3(6), TYK2(8) 8892236 45 40 38 13 12 7 10 9 7 0 0.258 1.000 1.000 254 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MIOX(4), OCRL(4), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CA(96), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9) 34052540 274 199 208 49 35 86 61 61 31 0 1.41e-07 1.000 1.000 255 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(2), EGF(9), EGFR(21), MET(4), PDGFRA(14), PRKCA(7), SH3GLB1(2), SH3GLB2(3), SH3KBP1(8) 14746309 73 67 73 21 9 16 23 13 11 1 0.208 1.000 1.000 256 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(2), ARRB2(3), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(5), CACNB2(7), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(4), CACNG6(5), CACNG7(4), CACNG8(8), CASP3(2), CD14(1), CDC25B(4), CDC42(4), CHUK(6), CRK(2), CRKL(3), DAXX(5), DDIT3(1), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(4), EGF(9), EGFR(21), ELK1(2), ELK4(4), FAS(5), FASLG(1), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FLNA(23), FLNB(10), FLNC(15), FOS(6), GADD45A(1), GADD45G(1), GNA12(2), GNG12(1), HRAS(32), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAPT(9), MAX(1), MEF2C(16), MKNK1(1), MKNK2(3), MOS(7), MYC(6), NF1(16), NFATC2(15), NFATC4(4), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(14), PDGFRB(8), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(5), PTPRR(5), RAC1(16), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(1), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(1), TAOK1(6), TAOK2(16), TAOK3(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TNFRSF1A(1), TP53(426), TRAF2(2), TRAF6(3), ZAK(5) 217349265 1646 472 1370 372 315 299 412 248 359 13 <1.00e-15 1.000 1.000 257 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(27), APC2(6), AXIN1(11), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(4), CCND2(2), CER1(1), CHD8(16), CREBBP(40), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTBP1(2), CTBP2(8), CTNNB1(6), CUL1(11), CXXC4(4), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(7), DVL2(1), DVL3(9), EP300(39), FBXW11(3), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(6), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(5), MMP7(1), MYC(6), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKD1(8), NKD2(3), NLK(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PORCN(2), PPARD(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAC1(16), RAC2(2), RAC3(3), RBX1(3), RHOA(10), ROCK1(19), ROCK2(10), SENP2(3), SFRP1(4), SFRP4(12), SFRP5(1), SIAH1(5), SKP1(1), SMAD2(4), SMAD3(4), SMAD4(15), SOX17(3), TBL1X(6), TBL1XR1(5), TBL1Y(3), TCF7(3), TCF7L1(2), TCF7L2(1), TP53(426), VANGL1(2), VANGL2(5), WIF1(1), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 123049105 1169 459 929 211 199 203 278 188 289 12 <1.00e-15 1.000 1.000 258 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(2), BCAR1(3), BCL2(1), BIRC2(2), BIRC3(2), BRAF(10), CAPN2(6), CAV1(1), CCND1(4), CCND2(2), CDC42(4), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(9), EGFR(21), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(23), FLNB(10), FLNC(15), FLT1(17), FN1(19), FYN(5), GSK3B(3), HGF(13), HRAS(32), IBSP(3), IGF1(1), IGF1R(13), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), JUN(1), KDR(13), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), MAP2K1(5), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(5), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PDPK1(4), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTEN(14), PTK2(10), PXN(3), RAC1(16), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(53), RHOA(10), ROCK1(19), ROCK2(10), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TLN1(24), TLN2(13), TNC(12), TNN(23), TNR(19), TNXB(23), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2) 282453904 1693 440 1579 482 262 391 515 272 247 6 1.61e-05 1.000 1.000 259 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(6), ACTN2(11), ACTN4(6), APC(27), APC2(6), ARAF(2), ARHGEF1(9), ARHGEF12(12), ARHGEF4(5), ARHGEF6(7), ARHGEF7(3), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), BCAR1(3), BDKRB1(3), BDKRB2(3), BRAF(10), CD14(1), CDC42(4), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CRK(2), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(9), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(9), EGFR(21), F2(3), F2R(4), FGD1(12), FGD3(5), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FN1(19), GIT1(5), GNA12(2), GNA13(2), GNG12(1), GSN(5), HRAS(32), IQGAP1(11), IQGAP2(6), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(7), MAP2K1(5), MAP2K2(6), MAPK1(9), MOS(7), MSN(3), MYH10(23), MYH14(7), MYH9(24), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), NCKAP1(8), NCKAP1L(8), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(14), PDGFRB(8), PFN1(1), PFN4(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(5), PTK2(10), PXN(3), RAC1(16), RAC2(2), RAC3(3), RAF1(3), RDX(1), RHOA(10), ROCK1(19), ROCK2(10), RRAS(2), RRAS2(1), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(7), SSH2(7), SSH3(5), TIAM1(15), TIAM2(13), TMSB4Y(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), WAS(2), WASF1(3), WASF2(5), WASL(2) 210031774 1193 404 1080 349 213 274 331 204 169 2 0.000307 1.000 1.000 260 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY7(5), ADCY8(28), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), AGTR1(14), ATP2A1(8), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), ATP2B4(6), AVPR1A(9), AVPR1B(7), BDKRB1(3), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(6), CD38(5), CHRM2(5), CHRM3(9), CHRM5(3), CHRNA7(2), CYSLTR1(2), CYSLTR2(5), DRD1(2), EDNRA(2), EDNRB(7), EGFR(21), ERBB2(11), ERBB3(14), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(12), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), LHCGR(9), LTB4R2(3), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(14), PDGFRB(8), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(7), PTGFR(2), PTK2B(4), RYR1(34), RYR2(79), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(17), SPHK2(5), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), TNNC2(1), TRHR(7), TRPC1(10) 204682270 1245 399 1238 427 261 267 357 208 151 1 0.00354 1.000 1.000 261 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(7), ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(4), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(14), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(6), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CNR1(4), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(5), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHB(2), FSHR(12), GABBR1(3), GABBR2(6), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GABRB1(8), GABRB2(8), GABRB3(15), GABRD(2), GABRE(8), GABRG1(10), GABRG2(8), GABRG3(8), GABRP(6), GABRQ(10), GABRR1(4), GABRR2(4), GALR1(4), GALR2(4), GALR3(2), GH1(4), GH2(7), GHR(8), GHRHR(4), GHSR(3), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(3), GLRA2(5), GLRA3(4), GLRB(4), GNRHR(3), GPR156(5), GPR35(2), GPR50(6), GPR63(6), GPR83(1), GRIA1(17), GRIA2(16), GRIA3(8), GRIA4(12), GRID1(20), GRID2(21), GRIK1(8), GRIK2(15), GRIK3(8), GRIK4(6), GRIK5(9), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM6(4), GRM7(19), GRM8(23), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LEP(1), LEPR(20), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(3), MAS1(2), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), MCHR1(3), MCHR2(5), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR1(1), NPBWR2(4), NPFFR2(17), NPY1R(6), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), P2RY8(3), PARD3(15), PRL(4), PRLHR(5), PRLR(8), PRSS1(10), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(7), PTGER4(6), PTGFR(2), PTGIR(2), PTH2R(12), RXFP1(5), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), THRA(7), THRB(1), TRHR(7), TRPV1(7), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(6) 168761211 1277 392 1269 439 228 242 432 215 159 1 0.00608 1.000 1.000 262 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(8), ABLIM1(8), ABLIM2(5), ABLIM3(5), ARHGEF12(12), CDC42(4), CDK5(3), CFL1(2), CXCL12(6), CXCR4(2), DCC(31), DPYSL2(5), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA2(27), EPHA3(20), EPHA4(11), EPHA5(25), EPHA6(18), EPHA7(24), EPHA8(5), EPHB1(16), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(6), FYN(5), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(32), ITGB1(17), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(7), LRRC4C(29), MAPK1(9), MET(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLXNA1(24), PLXNA2(17), PLXNA3(15), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTK2(10), RAC1(16), RAC2(2), RAC3(3), RASA1(17), RGS3(10), RHOA(10), RHOD(1), ROBO1(13), ROBO2(16), ROBO3(6), ROCK1(19), ROCK2(10), SEMA3A(14), SEMA3C(8), SEMA3D(5), SEMA3E(12), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(4), SEMA4C(3), SEMA4D(8), SEMA4F(5), SEMA4G(8), SEMA5A(28), SEMA5B(13), SEMA6A(3), SEMA6B(6), SEMA6C(1), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(25), SLIT3(9), SRGAP1(11), SRGAP2(2), SRGAP3(7), UNC5A(5), UNC5B(8), UNC5C(20), UNC5D(22) 149810079 1030 377 978 286 169 196 321 167 172 5 7.53e-05 1.000 1.000 263 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(5), ACTG1(3), CHAD(5), COL11A1(65), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(9), DSG2(3), DSG3(2), DSG4(5), FN1(19), GJA1(2), GJA10(7), GJA3(2), GJA4(1), GJA5(6), GJA8(8), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(3), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(11), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(4), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(5), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(4), KRT35(4), KRT36(6), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(3), KRT72(4), KRT73(4), KRT74(7), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(4), KRT8(1), KRT82(7), KRT83(6), KRT84(1), KRT85(5), KRT86(4), KRT9(3), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), LMNA(1), LMNB1(1), LMNB2(8), NES(13), RELN(53), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VIM(4), VTN(2), VWF(19) 189768350 1052 361 1046 364 175 214 355 150 153 5 0.393 1.000 1.000 264 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(5), ASH1L(20), CASK(4), CDC42(4), CDK4(5), CGN(5), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTTN(12), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(24), EXOC3(3), EXOC4(15), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(2), HRAS(32), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(14), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(7), MYH1(22), MYH10(23), MYH11(11), MYH13(28), MYH14(7), MYH15(14), MYH2(28), MYH3(14), MYH4(19), MYH6(20), MYH7(16), MYH7B(10), MYH8(26), MYH9(24), MYL7(2), MYL9(4), MYLPF(2), NRAS(1), OCLN(1), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP2R3A(14), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PTEN(14), RAB13(2), RHOA(10), RRAS(2), RRAS2(1), SPTAN1(24), SYMPK(7), TJAP1(4), TJP1(12), TJP2(5), TJP3(6), VAPA(2), YES1(3), ZAK(5) 147623367 894 353 856 259 152 191 284 139 126 2 0.00142 1.000 1.000 265 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(9), CD36(2), CD44(3), CD47(1), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DAG1(5), FN1(19), FNDC1(13), FNDC3A(11), FNDC4(3), FNDC5(1), GP5(4), GP6(3), GP9(2), HMMR(2), HSPG2(23), IBSP(3), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), RELN(53), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VTN(2), VWF(19) 170769936 958 352 952 321 154 208 303 143 146 4 0.285 1.000 1.000 266 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(7), ARRB1(2), ARRB2(3), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(16), CACNB1(5), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), ITPR1(16), ITPR2(26), ITPR3(10), KCNB1(3), KCNJ3(11), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(8), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(17), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 142455442 863 346 858 302 180 197 234 139 111 2 0.0237 1.000 1.000 267 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(3), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADM(1), ARRB1(2), ARRB2(3), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(6), CACNB3(3), CALCA(3), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CREB3(1), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(9), GJA1(2), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), GSTO1(2), GUCA2A(1), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(2), PDE4B(9), PDE4D(10), PKIG(1), PLCB3(8), PLCD1(4), PLCG1(8), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(23), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 131546288 757 332 754 265 141 186 212 120 96 2 0.0731 1.000 1.000 268 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(4), CCND2(2), CISH(1), CNTFR(1), CREBBP(40), CRLF2(4), CSF2RA(1), CSF2RB(8), CSF3R(3), EP300(39), EPO(2), EPOR(2), GH1(4), GH2(7), GHR(8), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL13RA2(4), IL19(4), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), IRF9(4), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(5), PIAS1(1), PIAS2(3), PIAS3(4), PIAS4(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIM1(3), PRL(4), PRLR(8), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(7), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(7), STAT2(6), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(11), TSLP(1), TYK2(8) 110583230 699 331 623 172 80 187 187 148 96 1 3.03e-06 1.000 1.000 269 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(16), ACACB(20), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(4), FOXO1(3), G6PC(2), G6PC2(7), GCK(4), GSK3B(3), GYS1(7), GYS2(7), HRAS(32), IKBKB(12), INPP5D(10), INSR(3), IRS1(4), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(5), MKNK1(1), MKNK2(3), NRAS(1), PCK1(1), PCK2(4), PDE3A(18), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(13), PPP1R3B(3), PPP1R3C(2), PPP1R3D(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAG3(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(17), PYGB(5), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(5), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(5), TSC2(8) 121848627 714 326 618 191 133 175 185 129 92 0 1.72e-05 1.000 1.000 270 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(6), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(3), BCAR1(3), BRAF(10), CAV1(1), CDC42(4), CDKN2A(116), CRK(2), CSE1L(2), DOCK1(15), EPHB2(3), FYN(5), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(4), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CA(96), PIK3CB(7), PKLR(3), PLCG1(8), PLCG2(9), PTEN(14), PTK2(10), RAF1(3), RHO(3), ROCK1(19), ROCK2(10), SHC1(3), SOS1(9), SOS2(11), TLN1(24), TLN2(13), VASP(1), WAS(2), ZYX(2) 93006234 631 326 500 139 79 133 142 115 160 2 1.34e-07 1.000 1.000 271 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(2), CCL3(1), CCL8(3), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(5), CNTFR(1), CRLF2(4), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(8), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(1), CXCL14(1), CXCL16(3), CXCL2(1), CXCL3(1), CXCL5(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(4), EDA2R(1), EDAR(2), EGF(9), EGFR(21), EPO(2), EPOR(2), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(13), GDF5(4), GH1(4), GH2(7), GHR(8), HGF(13), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(6), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), INHBA(4), INHBB(4), INHBC(3), INHBE(1), KDR(13), KIT(11), KITLG(1), LEP(1), LEPR(20), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(2), OSMR(5), PDGFB(1), PDGFC(3), PDGFRA(14), PDGFRB(8), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(4), PRLR(8), RELT(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(2), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(11), TSLP(1), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3) 134718817 716 314 703 228 109 142 226 129 109 1 0.0836 1.000 1.000 272 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FCGR3B(5), FYN(5), GZMB(2), HLA-A(24), HLA-B(26), HLA-C(5), HLA-E(1), HLA-G(2), HRAS(32), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), ITGAL(7), ITGB2(4), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KLRC1(1), KLRC2(1), KLRC3(4), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MICB(3), NCR1(6), NCR2(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NRAS(1), PAK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRF1(4), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC1(16), RAC2(2), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 86347259 642 313 530 146 109 149 157 116 111 0 3.31e-08 1.000 1.000 273 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(4), CADM3(5), CD2(1), CD22(3), CD226(5), CD274(1), CD276(1), CD28(3), CD34(6), CD4(1), CD40(7), CD40LG(5), CD58(2), CD6(1), CD80(5), CD86(2), CD8A(2), CD8B(2), CD99(1), CDH1(5), CDH15(3), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(11), CNTN2(8), CNTNAP1(9), CNTNAP2(27), CTLA4(2), ESAM(4), F11R(3), GLG1(4), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(13), ITGA6(4), ITGA8(22), ITGA9(3), ITGAL(7), ITGAM(8), ITGAV(6), ITGB1(17), ITGB2(4), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(4), NCAM2(13), NEGR1(7), NEO1(4), NFASC(6), NLGN1(19), NLGN2(6), NLGN3(3), NRCAM(14), NRXN1(31), NRXN2(10), NRXN3(24), OCLN(1), PDCD1(2), PTPRC(19), PTPRF(17), PTPRM(25), PVR(5), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SELE(7), SELL(2), SELP(15), SELPLG(1), SIGLEC1(13), SPN(3), VCAM1(10), VCAN(32) 112239504 715 310 700 244 105 140 202 126 142 0 0.218 1.000 1.000 274 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2L1(2), CDC42(4), CDKN1B(3), CDKN2A(116), CREB1(1), CREB3(1), CREB5(8), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CA(96), PIK3CD(8), PPP1R13B(2), PREX1(15), PTEN(14), PTK2(10), PTPN1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SLC2A4(4), SOS1(9), SOS2(11), TSC1(5), TSC2(8), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 58818315 523 308 399 91 50 127 102 92 150 2 6.12e-12 1.000 1.000 275 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(6), ACTN2(11), ACTN4(6), ARHGAP5(10), BCAR1(3), CD99(1), CDC42(4), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), CXCL12(6), CXCR4(2), CYBB(3), ESAM(4), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), ITK(3), JAM2(2), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), MYLPF(2), NCF1(2), NCF2(6), NCF4(3), NOX1(6), NOX3(8), OCLN(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAC1(16), RAC2(2), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOA(10), RHOH(1), ROCK1(19), ROCK2(10), SIPA1(3), THY1(2), TXK(5), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCAM1(10), VCL(6) 94614174 628 307 550 168 95 154 153 128 97 1 0.000240 1.000 1.000 276 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(11), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), BTC(3), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(3), CRK(2), CRKL(3), EGF(9), EGFR(21), EIF4EBP1(1), ELK1(2), ERBB2(11), ERBB3(14), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), HRAS(32), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(5), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(4), NRG2(6), NRG3(17), NRG4(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), RAF1(3), RPS6KB1(5), RPS6KB2(2), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), STAT5A(3), STAT5B(5) 78327720 583 306 486 140 77 152 171 119 63 1 1.94e-05 1.000 1.000 277 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADK(2), ADSL(5), ADSS(4), ADSSL1(6), AK1(1), AK2(1), AK5(12), AK7(2), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(1), GART(4), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE10A(20), PDE11A(3), PDE1A(6), PDE1C(14), PDE2A(4), PDE3B(4), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PDE9A(3), PFAS(13), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(6) 124133963 636 304 633 202 111 137 192 105 91 0 0.0866 1.000 1.000 278 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(9), EGFR(21), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(12), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HRAS(32), HTR2A(5), HTR2B(2), HTR2C(3), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(1), MAPK1(9), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), TJP1(12), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2) 100460063 635 304 599 175 125 138 191 112 68 1 3.92e-05 1.000 1.000 279 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(3), CDC42(4), CDH1(5), CREBBP(40), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), EGFR(21), EP300(39), ERBB2(11), FARP2(3), FER(6), FGFR1(4), FYN(5), IGF1R(13), INSR(3), IQGAP1(11), LEF1(6), LMO7(8), MAP3K7(8), MAPK1(9), MET(4), MLLT4(13), NLK(1), PARD3(15), PTPN1(3), PTPN6(3), PTPRB(24), PTPRF(17), PTPRJ(7), PTPRM(25), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(3), RAC1(16), RAC2(2), RAC3(3), RHOA(10), SMAD2(4), SMAD3(4), SMAD4(15), SNAI2(1), SORBS1(7), SSX2IP(6), TCF7(3), TCF7L1(2), TCF7L2(1), TGFBR1(2), TGFBR2(25), TJP1(12), VCL(6), WAS(2), WASF1(3), WASF2(5), WASF3(7), WASL(2), YES1(3) 90985072 591 301 552 153 102 122 156 107 102 2 0.00107 1.000 1.000 280 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(4), CGA(1), EGFR(21), ELK1(2), FSHB(2), GNA11(4), GNAS(12), GNRHR(3), HRAS(32), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(5), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLD1(17), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11) 96498983 586 300 550 177 122 130 171 97 66 0 0.00162 1.000 1.000 281 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(10), INPP5E(1), INPPL1(9), ITPK1(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), OCRL(4), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3C3(5), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PRKCA(7), PRKCG(14), PTEN(14), PTPMT1(2), SYNJ1(10), SYNJ2(9) 94528826 588 298 520 144 79 157 137 124 91 0 1.32e-06 1.000 1.000 282 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(4), AKT3(6), CASP8(61), CCL3(1), CD14(1), CD40(7), CD80(5), CD86(2), CHUK(6), CXCL10(2), CXCL9(3), FADD(4), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IKBKB(12), IKBKE(5), IL12A(1), IL12B(4), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(3), IRF5(3), IRF7(3), JUN(1), LBP(8), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), RAC1(16), RELA(2), RIPK1(2), SPP1(2), STAT1(7), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(3), TLR3(2), TLR4(16), TLR5(4), TLR6(4), TLR7(8), TLR8(7), TLR9(7), TOLLIP(2), TRAF3(6), TRAF6(3) 68325840 529 298 439 118 75 143 121 97 91 2 3.32e-08 1.000 1.000 283 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(5), CD8A(2), CD8B(2), CDC42(4), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(5), GRAP2(2), HRAS(32), ICOS(1), IFNG(2), IKBKB(12), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDCD1(2), PDK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCQ(8), PTPN6(3), PTPRC(19), RASGRP1(8), RHOA(10), SOS1(9), SOS2(11), TEC(2), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 77308677 528 298 439 128 75 134 142 103 74 0 7.67e-05 1.000 1.000 284 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(1), CREB3L1(4), CREB3L2(3), CREB3L3(10), CREB3L4(2), CREBBP(40), CTNNB1(6), DCT(4), DVL1(7), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), EP300(39), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GSK3B(3), HRAS(32), KIT(11), KITLG(1), KRAS(1), LEF1(6), MAP2K1(5), MAP2K2(6), MAPK1(9), MC1R(2), MITF(7), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), POMC(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(3), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 83004478 560 297 518 147 124 104 160 95 75 2 4.52e-06 1.000 1.000 285 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(3), ACTN2(11), ACTN4(6), DES(3), DMD(53), MYBPC1(13), MYBPC2(8), MYBPC3(5), MYH3(14), MYH6(20), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(42), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(4), TNNT3(3), TPM1(2), TPM2(2), TPM4(1), TTN(434), VIM(4) 103717356 706 297 700 198 93 180 252 105 70 6 0.109 1.000 1.000 286 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), AKAP1(8), AKAP10(5), AKAP11(8), AKAP12(13), AKAP2(1), AKAP3(8), AKAP4(11), AKAP5(3), AKAP6(27), AKAP7(5), AKAP8(4), AKAP9(30), ARHGEF1(9), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(2), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB5(2), GNG10(1), GNG12(1), GNG13(2), HRAS(32), IL18BP(1), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PLCB3(8), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RHOA(10), RRAS(2), SLC9A1(4), USP5(5) 88823249 572 295 542 141 114 129 162 92 75 0 5.91e-06 1.000 1.000 287 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(5), ACVRL1(4), AKT1(2), AURKB(3), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(8), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MAP3K10(6), MOS(7), NEK1(9), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CA(96), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9), PLK3(6), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(8), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KB1(5), STK11(7), TGFBR1(2), VRK1(1) 85727976 559 294 491 138 85 141 148 105 80 0 1.21e-05 1.000 1.000 288 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(14), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(8), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(6), GPR6(5), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LHCGR(9), LTB4R(3), MAS1(2), MC1R(2), MC3R(4), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(8), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(2), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), RGR(4), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SUCNR1(1), TBXA2R(1), TRHR(7) 92553685 586 287 583 227 118 125 193 95 55 0 0.0507 1.000 1.000 289 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(22), ADCY8(28), ARAF(2), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(40), EP300(39), GRIA1(17), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), HRAS(32), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP1CA(1), PPP1R12A(5), PPP1R1A(2), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8) 75495212 568 286 526 164 102 125 161 107 72 1 0.000767 1.000 1.000 290 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADK(2), ADSL(5), ADSS(4), AK1(1), AK2(1), AK5(12), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(4), GDA(7), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(13), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(1), RRM2(1) 97524512 517 274 514 158 88 111 167 76 75 0 0.0370 1.000 1.000 291 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(5), GAB2(4), HRAS(32), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(10), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MS4A2(5), NRAS(1), PDK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC1(16), RAC2(2), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8), VAV2(4), VAV3(4) 54837372 435 264 335 96 72 112 113 83 54 1 2.52e-06 1.000 1.000 292 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(2), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GNAZ(7), GRIA1(17), GRIA2(16), GRIA3(8), GRID2(21), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HRAS(32), IGF1(1), IGF1R(13), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), RAF1(3), RYR1(34) 83587934 530 262 498 153 104 105 164 95 62 0 0.00588 1.000 1.000 293 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BMPR1B(4), BMPR2(6), CHRD(12), CREBBP(40), CUL1(11), DCN(4), E2F4(2), E2F5(6), EP300(39), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(4), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(9), MYC(6), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), RBL1(11), RBL2(6), RBX1(3), RHOA(10), ROCK1(19), ROCK2(10), RPS6KB1(5), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD4(15), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(3), SMURF2(6), SP1(3), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), THBS1(8), THBS2(11), THBS3(4), THBS4(7), ZFYVE16(10), ZFYVE9(8) 75337553 463 261 434 101 57 101 125 85 94 1 7.37e-06 1.000 1.000 294 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(5), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(9), FCGR2B(1), FOS(6), GSK3B(3), HRAS(32), IKBKB(12), INPP5D(10), JUN(1), KRAS(1), LILRB3(5), LYN(8), MALT1(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC1(16), RAC2(2), RAC3(3), RASGRP3(8), SYK(8), VAV1(8), VAV2(4), VAV3(4) 56724681 438 261 345 95 74 122 102 86 53 1 2.12e-07 1.000 1.000 295 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(4), AKT3(6), BAD(2), CASP9(1), CDC42(4), HRAS(32), KDR(13), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(4), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NOS3(4), NRAS(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCA(7), PRKCG(14), PTGS2(4), PTK2(10), PXN(3), RAC1(16), RAC2(2), RAC3(3), RAF1(3), SHC2(5), SPHK2(5) 54870143 426 259 326 97 81 118 100 80 47 0 5.47e-07 1.000 1.000 296 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), AMY2B(9), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(7), GAA(3), GANC(6), GBA(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), IFIH1(6), MGAM(37), MOV10L1(6), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SI(61), SKIV2L2(4), SMARCA2(13), SMARCA5(2), TREH(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UXS1(2) 94008768 473 247 471 145 56 95 154 95 71 2 0.309 1.000 1.000 297 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(13), ABCA12(19), ABCA13(39), ABCA2(17), ABCA3(10), ABCA4(15), ABCA5(6), ABCA6(11), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(20), ABCB11(9), ABCB4(13), ABCB5(12), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(9), ABCC12(11), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(9), ABCG8(13), CFTR(14), TAP1(6), TAP2(6) 89789433 441 247 439 143 65 93 133 70 80 0 0.0709 1.000 1.000 298 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(5), BAD(2), BCL2(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(4), CREBBP(40), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), EP300(39), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(9), GSK3A(2), GSK3B(3), HRAS(32), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(5), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB2(5), NFKBIB(2), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(19), RELA(2), RPL13A(2), SFN(7), SLA(3), SP1(3), SP3(3), TGFB1(2), TRAF2(2), TRPV6(7), VAV1(8), VAV2(4), VAV3(4), XPO5(4) 69365760 402 244 371 117 58 77 124 76 66 1 0.0390 1.000 1.000 299 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(4), CAPN11(2), CAPN2(6), CAPN3(5), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(4), CAPNS1(2), CAV1(1), CDC42(4), CRK(2), CSK(1), DOCK1(15), FYN(5), GIT2(3), ILK(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(8), MAPK6(3), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(10), PXN(3), RAC1(16), RAC2(2), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(10), SDCCAG8(7), SEPP1(3), SHC1(3), SHC3(6), SORBS1(7), SOS1(9), TLN1(24), TNS1(8), VASP(1), VAV2(4), VAV3(4), VCL(6), ZYX(2) 101861619 499 244 487 154 87 108 146 77 81 0 0.0283 1.000 1.000 300 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(9), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(4), MIOX(4), OCRL(4), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PTEN(14), PTPMT1(2), SYNJ1(10), SYNJ2(9) 56518984 382 243 316 93 57 107 88 80 50 0 1.32e-05 1.000 1.000 301 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA2(1), CD36(2), CPT1B(4), CREBBP(40), DUSP1(2), EHHADH(5), EP300(39), FABP1(4), HSD17B4(5), JUN(1), LPL(4), MAPK1(9), ME1(2), MYC(6), NCOA1(7), NCOR1(21), NCOR2(24), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(9), PIK3CA(96), PIK3R1(10), PPARA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(4), RB1(18), RELA(2), RXRA(5), SP1(3), STAT5A(3), STAT5B(5) 48149726 364 241 282 65 39 120 72 67 65 1 3.13e-09 1.000 1.000 302 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(9), ARHGEF11(4), BTK(8), CDC42(4), CFL1(2), GDI1(4), GDI2(5), INPPL1(9), ITPR1(16), ITPR2(26), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3CG(20), PIK3R1(10), PITX2(2), PPP1R13B(2), PTEN(14), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(10), SAG(1), WASF1(3), WASL(2) 53221706 363 234 300 102 45 121 73 77 46 1 0.00222 1.000 1.000 303 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(4), CREBBP(40), CTBP1(2), CTBP2(8), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(7), DVL2(1), DVL3(9), EP300(39), HDAC1(1), HDAC2(3), JAG1(7), JAG2(8), LFNG(3), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(24), NCSTN(2), NOTCH1(95), NOTCH2(21), NOTCH3(23), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(8), RBPJL(5), RFNG(3), SNW1(5) 52922862 383 231 371 110 67 78 82 52 102 2 0.0254 1.000 1.000 304 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(5), ELK1(2), FOS(6), HRAS(32), IKBKB(12), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAP4K5(2), MAPK1(9), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(8), MAPK6(3), MAPK7(6), MAPK8(4), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), MKNK1(1), MKNK2(3), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAC1(16), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(5), RPS6KB2(2), SHC1(3), SP1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 72623910 403 231 361 110 78 80 132 61 52 0 0.0205 1.000 1.000 305 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(10), CPEB1(6), EGFR(21), ERBB2(11), ERBB4(22), ETS1(4), ETS2(7), ETV6(6), ETV7(4), FMN2(41), KRAS(1), MAP2K1(5), MAPK1(9), NOTCH1(95), NOTCH2(21), NOTCH3(23), NOTCH4(8), PIWIL1(11), PIWIL2(9), PIWIL3(7), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1) 39865975 353 230 339 86 55 64 96 51 86 1 0.0238 1.000 1.000 306 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), BCR(2), BLNK(5), BTK(8), CD19(4), CD22(3), CR2(9), CSK(1), DAG1(5), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), INPP5D(10), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), MAP4K1(4), MAPK1(9), NFATC1(10), NFATC2(15), NR0B2(1), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(19), RAF1(3), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 56212303 364 226 295 96 54 114 64 87 44 1 0.000270 1.000 1.000 307 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(7), BDKRB1(3), BDKRB2(3), C1QA(3), C1QC(1), C1R(4), C1S(6), C2(2), C3(16), C3AR1(5), C4BPA(5), C4BPB(2), C5(11), C5AR1(2), C6(25), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(3), CD55(1), CD59(1), CFB(8), CFH(19), CFI(5), CPB2(4), CR1(10), CR2(9), F10(4), F11(2), F12(2), F13A1(8), F13B(13), F2(3), F2R(4), F3(2), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), KNG1(5), MASP1(9), MASP2(5), MBL2(2), PLAT(3), PLAU(3), PLG(13), PROC(2), PROS1(9), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(8), SERPING1(5), TFPI(2), THBD(2), VWF(19) 68851679 414 218 411 138 50 104 119 73 67 1 0.390 1.000 1.000 308 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(3), CHPF(7), CHST1(4), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST2(5), CHST4(4), CHST6(8), CHST7(2), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GANAB(3), GCNT1(1), GCNT3(1), GCNT4(3), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST6GAL1(3), ST6GALNAC1(4), STT3B(2), UST(3), WBSCR17(9), XYLT1(10), XYLT2(3) 84055408 358 217 358 141 74 72 115 50 46 1 0.794 1.000 1.000 309 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), MAPK1(9), PDPK1(4), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PRKAA1(4), PRKAA2(4), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), STK11(7), TSC1(5), TSC2(8), ULK1(8), ULK2(2), VEGFB(1), VEGFC(6) 40431581 303 211 232 55 43 98 58 62 42 0 1.97e-07 1.000 1.000 310 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(11), EZH1(5), EZH2(5), FBXO11(7), HCFC1(8), HSF4(1), JMJD4(2), JMJD6(2), KDM6A(17), MEN1(3), NSD1(73), OGT(4), PAXIP1(5), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(37), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(2), SATB1(6), SETD1A(11), SETD2(12), SETD7(4), SETD8(1), SETDB1(10), SETDB2(2), SETMAR(2), SMYD3(2), STK38(3), SUV39H1(5), SUV39H2(2), SUV420H1(8), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6) 90336613 354 209 348 81 45 61 98 55 89 6 0.0105 1.000 1.000 311 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(21), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), MAPK10(4), MAPK14(2), PHKA2(9), PIK3CA(96), PIK3CD(8), PIK3R1(10), PITX2(2), PTX3(4), RAF1(3) 40448312 303 207 233 64 39 101 58 71 34 0 2.11e-06 1.000 1.000 312 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCR(2), BLNK(5), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PI3(2), PIK3CA(96), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 40209608 280 204 212 59 44 87 53 58 37 1 6.45e-06 1.000 1.000 313 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(20), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(2), CAMKK2(6), CD36(2), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(7), IKBKB(12), IRS1(4), IRS2(6), IRS4(16), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), MAPK10(4), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NPY(5), PCK1(1), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(5), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), STK11(7), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8) 63166369 321 194 321 102 55 62 96 55 52 1 0.112 1.000 1.000 314 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(6), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), CRADD(1), DAXX(5), FADD(4), GSN(5), LMNA(1), LMNB1(1), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(2), NFKB1(5), NFKBIA(1), NUMA1(18), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(10), RASA1(17), RB1(18), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 52736295 302 190 288 74 35 56 73 47 88 3 0.0128 1.000 1.000 315 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(14), AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(3), GRPR(1), LHCGR(9), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), NMBR(3), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), TACR1(3), TACR2(4), TACR3(6), TRHR(7), TSHR(4) 39853918 288 187 287 97 54 69 88 43 34 0 0.0134 1.000 1.000 316 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(2), ITGA9(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), MAP2K1(5), MAPK1(9), NR1I3(1), PAK1(3), PDE3A(18), PDE3B(4), PI3(2), PIK3C2G(13), PIK3CA(96), PIK3CD(8), PIK3R1(10), PSME1(1), RIPK3(1), SGCB(3), VASP(1) 36911873 255 184 186 58 27 91 45 57 35 0 0.000186 1.000 1.000 317 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLD1(17), PPP1R12B(5), RAC1(16), RALBP1(5), RPS6KB1(5), TRIO(22), VAV1(8), WASF1(3) 26559896 242 181 174 53 29 88 51 48 26 0 0.000296 1.000 1.000 318 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(6), CPSF2(5), CPSF3(2), CSTF1(2), CSTF2(2), CSTF2T(2), CSTF3(2), DDIT3(1), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(2), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(3), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(11), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(13), PTBP1(3), PTBP2(4), RBM17(1), RBM5(9), RNGTT(2), RNMT(5), RNPS1(5), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(4), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(5), SRPK1(1), SRPK2(8), SRRM1(4), SUPT5H(4), U2AF1(4), U2AF2(2), XRN2(8) 80511676 293 179 291 103 34 71 83 51 54 0 0.815 1.000 1.000 319 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(4), CD1A(7), CD1B(3), CD1C(5), CD1D(5), CD1E(14), CD2(1), CD22(3), CD33(2), CD34(6), CD36(2), CD37(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD55(1), CD59(1), CD7(2), CD8A(2), CD8B(2), CD9(1), CR1(10), CR2(9), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(3), EPO(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), GYPA(5), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL7(1), IL7R(6), IL9R(11), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(8), KIT(11), KITLG(1), MME(16), MS4A1(3), TFRC(7), THPO(1), TPO(11) 62037120 297 178 294 115 47 62 86 56 46 0 0.828 1.000 1.000 320 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(4), CCKBR(6), CCR2(5), CCR3(6), CELSR1(23), CELSR2(25), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(4), GNRHR(3), GPR116(8), GPR132(4), GPR133(10), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR61(3), GPR84(3), GRM1(30), GRPR(1), HRH4(3), LGR6(10), LPHN2(11), LPHN3(24), LTB4R2(3), NTSR1(3), OR2M4(6), P2RY13(3), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2) 50653530 279 173 278 108 52 63 84 46 34 0 0.322 1.000 1.000 321 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(5), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(4), CHUK(6), CSK(1), CXCL1(3), EGFR(21), F11R(3), GIT1(5), IGSF5(4), IKBKB(12), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(8), PAK1(3), PLCG1(8), PLCG2(9), PTPN11(2), PTPRZ1(16), RAC1(16), RELA(2), TCIRG1(8), TJP1(12) 53414859 259 172 251 75 33 58 77 51 40 0 0.140 1.000 1.000 322 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(5), CCND1(4), CREBBP(40), EP300(39), ERCC3(5), ESR1(6), GRIP1(11), GTF2A1(3), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), MEF2C(16), NCOR2(24), NR0B1(5), NRIP1(9), PELP1(2), POLR2A(11), TBP(2) 34991761 233 169 225 67 24 47 65 48 48 1 0.110 1.000 1.000 323 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), FBXW7(34), GRAP2(2), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), MAPK1(9), NCK1(5), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLCG1(8), PTPRC(19), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), SOS1(9), SOS2(11), VAV1(8), ZAP70(2) 42523276 231 169 215 68 36 39 69 32 54 1 0.279 1.000 1.000 324 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(27), AXIN1(11), CCND1(4), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(7), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(6), MAPK10(4), MAPK9(5), MYC(6), PAFAH1B1(1), PLAU(3), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), RAC1(16), RHOA(10), SFRP4(12), TCF7(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1) 45758600 274 169 260 86 46 58 86 55 28 1 0.0914 1.000 1.000 325 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(73), OGDH(11), OGDHL(12), PIPOX(2), PLOD1(3), PLOD2(8), PLOD3(4), RDH11(2), RDH12(4), SETD1A(11), SETD7(4), SETDB1(10), SHMT1(1), SHMT2(2), SPCS1(2), SPCS3(1), SUV39H1(5), SUV39H2(2), TMLHE(2) 44109520 248 168 247 65 36 41 62 39 64 6 0.0535 1.000 1.000 326 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), AMY2B(9), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), MGAM(37), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), SI(61), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UXS1(2) 43197822 255 167 253 83 30 48 82 52 41 2 0.494 1.000 1.000 327 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(10), JAK1(11), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PIK3CA(96), PPP1R13B(2), RPS6KB1(5), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), STAT6(5), TYK2(8) 28058909 216 166 155 45 21 79 45 54 17 0 6.55e-05 1.000 1.000 328 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ANGPTL4(3), APOA2(1), APOA5(2), AQP7(3), CD36(2), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(3), CYP4A11(13), CYP4A22(10), CYP7A1(6), CYP8B1(6), DBI(5), EHHADH(5), FABP1(4), FABP2(2), FABP3(1), FABP4(4), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(5), GK2(8), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(7), NR1H3(1), OLR1(1), PCK1(1), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRA(5), RXRB(3), RXRG(7), SCD(1), SCP2(2), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1) 49785711 239 164 238 85 40 56 67 36 39 1 0.395 1.000 1.000 329 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(21), EPHB2(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), PI3(2), PIK3CB(7), PITX2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), RAF1(3), RGS20(4), SHC1(3), SOS1(9), SOS2(11), STAT3(6) 44362804 237 164 229 76 40 52 64 57 24 0 0.163 1.000 1.000 330 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(7), GNA15(4), GNB1(3), HRAS(32), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NCF1(2), NCF2(6), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(13), PLCB1(21), PPP3CA(2), PPP3CB(1), RAC1(16), RAF1(3), RELA(2), SYT1(8) 29082466 208 158 169 48 53 32 71 29 23 0 0.00582 1.000 1.000 331 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UPB1(2), UPP1(3), UPP2(4), UPRT(2) 61520900 242 158 242 92 40 43 67 51 41 0 0.864 1.000 1.000 332 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(15), GLI3(12), GSK3B(3), HHIP(7), IHH(2), LRP2(42), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(14), PTCH2(11), RAB23(2), SHH(2), SMO(3), STK36(7), SUFU(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3), ZIC2(6) 46317598 240 158 239 90 52 46 83 34 25 0 0.567 1.000 1.000 333 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CFLAR(2), DAXX(5), FADD(4), FAF1(2), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(13), RB1(18), RIPK2(6), SPTAN1(24) 31054098 219 157 206 39 22 42 53 33 67 2 0.000780 1.000 1.000 334 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 BCL2(1), CHUK(6), DAXX(5), EGF(9), EGFR(21), ETS1(4), ETS2(7), FOS(6), HOXA7(4), HRAS(32), IKBKB(12), JUN(1), MAP2K1(5), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(1), TNFRSF1B(2), TRAF2(2) 37521254 214 155 184 64 43 39 72 31 28 1 0.110 1.000 1.000 335 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(14), GNAS(12), GNAT3(6), GNB1(3), GNB3(7), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(4), SCNN1B(6), SCNN1G(6), TAS1R1(8), TAS1R2(3), TAS1R3(3), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R14(5), TAS2R16(4), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R40(8), TAS2R41(3), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(6) 43345617 230 150 228 108 50 42 54 47 37 0 0.932 1.000 1.000 336 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(13), KDR(13), NOS3(4), PDE2A(4), PDE3A(18), PDE3B(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKG1(8), PRKG2(2), RYR2(79), SLC7A1(4), SYT1(8) 30730065 205 149 205 74 34 52 58 37 23 1 0.516 1.000 1.000 337 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(6), CASP2(3), CASP3(2), CASP8(61), CRADD(1), FADD(4), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(18), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TRADD(1), TRAF2(2) 29604604 206 149 193 43 23 34 55 32 60 2 0.00705 1.000 1.000 338 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(12), BAD(2), BAX(2), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CD40(7), CD40LG(5), CRADD(1), DAXX(5), FADD(4), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(2), NR3C1(6), NTRK1(3), PTPN13(13), RIPK1(2), TFG(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3) 33094398 192 148 180 37 25 43 40 31 51 2 0.000411 1.000 1.000 339 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT2(2), ACMSD(4), AFMID(6), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), NFX1(2), OGDH(11), OGDHL(12), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(4), TPH1(2), TPH2(6), WARS(2), WARS2(8) 45967534 202 147 202 65 29 45 64 32 32 0 0.306 1.000 1.000 340 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(4), DGAT1(1), DGAT2(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), GK(5), GK2(8), GLA(3), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 44508420 201 144 200 61 26 44 53 41 37 0 0.113 1.000 1.000 341 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(10), CALR(2), CANX(3), CD4(1), CD74(3), CD8A(2), CD8B(2), CIITA(12), CREB1(1), CTSS(4), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(9), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(4), LGMN(5), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(2), TAP1(6), TAP2(6), TAPBP(5) 35345030 222 144 210 64 22 45 59 30 66 0 0.116 1.000 1.000 342 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39948764 215 141 209 75 34 49 66 27 38 1 0.373 1.000 1.000 343 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39948764 215 141 209 75 34 49 66 27 38 1 0.373 1.000 1.000 344 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(6), ACTN2(11), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(5), HRAS(32), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK8(4), PPP1R12B(5), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), SOS1(9), TLN1(24), VCL(6), ZYX(2) 35893183 205 139 174 43 43 32 77 32 21 0 0.00233 1.000 1.000 345 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(2), ACMSD(4), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(2), WARS(2), WARS2(8) 41837003 188 139 188 65 25 40 62 33 27 1 0.482 1.000 1.000 346 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(7), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 44194172 185 138 185 78 29 49 48 30 29 0 0.808 1.000 1.000 347 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C2(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7) 43717129 210 138 210 81 29 43 68 41 28 1 0.783 1.000 1.000 348 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), RRM1(1), RRM2(1), TXNRD1(6), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UNG(2), UPB1(2), UPP1(3) 43605398 187 138 187 60 27 34 59 32 35 0 0.374 1.000 1.000 349 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(5), GNA11(4), GNAI1(2), GNB1(3), HRAS(32), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), SYT1(8) 31586294 180 135 150 48 45 36 60 24 15 0 0.0172 1.000 1.000 350 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(2), CARM1(5), CYP11B1(7), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7) 38193915 185 135 185 60 34 33 60 36 22 0 0.374 1.000 1.000 351 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(22), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(12), GNB1(3), HRAS(32), JUN(1), MAP2K1(5), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(8) 26575351 175 134 151 34 43 31 58 25 18 0 0.000279 1.000 1.000 352 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(4), CREB1(1), DAXX(5), DDIT3(1), ELK1(2), HMGN1(1), HRAS(32), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(16), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RAC1(16), RIPK1(2), RPS6KA5(5), SHC1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 27836826 165 133 132 40 31 33 55 23 23 0 0.0435 1.000 1.000 353 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(5), EPHB2(3), GNAI1(2), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), PITX2(2), PTX3(4), RAC1(16), RHO(3), RYR1(34) 34733583 183 133 168 60 44 41 40 29 29 0 0.0951 1.000 1.000 354 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHFR(3), DHX58(2), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), FPGS(2), GGH(3), IFIH1(6), MOV10L1(6), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SKIV2L2(4), SMARCA2(13), SMARCA5(2) 47813003 180 132 180 55 23 36 58 35 28 0 0.365 1.000 1.000 355 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(4), CFL1(2), FLNA(23), FLNC(15), FSCN1(2), FSCN2(1), FSCN3(6), GDI1(4), GDI2(5), LIMK1(5), MYH2(28), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PFN1(1), RHO(3), ROCK1(19), ROCK2(10), VASP(1), WASF1(3), WASL(2) 36437833 191 132 191 75 32 45 53 28 33 0 0.659 1.000 1.000 356 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(10), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(1), NDUFA2(1), NDUFA3(3), NDUFA5(3), NDUFA7(2), NDUFA9(2), NDUFB1(1), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(5), PPA1(1), SDHA(7), SDHB(1), SDHC(1), TCIRG1(8), UQCRC1(1), UQCRC2(1), UQCRFS1(4) 42404427 177 130 176 47 18 38 59 33 29 0 0.0872 1.000 1.000 357 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(3), CAPN2(6), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(21), HRAS(32), ITGA1(4), ITGB1(17), MAPK1(9), MYLK(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTK2(10), PXN(3), TLN1(24) 24863168 171 128 139 43 38 27 58 28 19 1 0.0339 1.000 1.000 358 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(3), ALOX12B(5), ALOX15B(5), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP2U1(1), CYP4A11(13), CYP4A22(10), CYP4F2(7), CYP4F3(4), DHRS4(2), EPHX2(4), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), LTA4H(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 29595932 162 127 162 51 22 34 50 27 28 1 0.141 1.000 1.000 359 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(27), ATF2(1), AXIN1(11), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(12), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), MAP3K7(8), MEF2C(16), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TGFBR3(5), WNT1(2) 27783473 179 126 168 41 24 41 40 37 36 1 0.0115 1.000 1.000 360 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), GK(5), GLA(3), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 36570399 166 126 165 52 21 33 45 31 36 0 0.193 1.000 1.000 361 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(35), B3GALT4(4), CDR1(7), DGKI(11), IL6ST(4), MRPL19(3), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL18A(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(3), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5) 39813299 179 126 179 71 21 39 67 25 27 0 0.909 1.000 1.000 362 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), F10(4), F11(2), F12(2), F2(3), F2R(4), F5(20), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), PROC(2), PROS1(9), SERPINC1(4), SERPING1(5) 33727835 171 125 170 55 16 52 47 31 25 0 0.585 1.000 1.000 363 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), CARM1(5), COMT(2), DBH(8), DCT(4), DDC(7), ECH1(2), ESCO1(4), ESCO2(4), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PNMT(1), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(8), TYRP1(4) 45187717 164 124 163 54 28 40 48 23 25 0 0.265 1.000 1.000 364 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(6), CFL1(2), GNAS(12), GNB1(3), HRAS(32), LIMK1(5), MAP2K1(5), MAPK1(9), NOX1(6), PIK3C2G(13), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2(10), RAF1(3), ROCK2(10) 19131878 149 123 117 32 32 25 57 17 18 0 0.0324 1.000 1.000 365 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(4), AKT3(6), ANKRD6(3), APC(27), AXIN1(11), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(7), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(34), MVP(5), NKD1(8), NKD2(3), PIN1(1), PTPRA(4), SENP2(3), SFRP1(4), TSHB(2), WIF1(1) 30754359 163 123 162 56 22 39 43 33 25 1 0.453 1.000 1.000 366 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(3), GNPAT(3), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(2) 49774432 185 122 184 52 20 38 55 31 41 0 0.113 1.000 1.000 367 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(4), AKT3(6), ARHGEF11(4), BCL2(1), CDC42(4), DLG4(5), GNA13(2), LPA(16), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PI3(2), PIK3CB(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RDX(1), ROCK1(19), ROCK2(10), SERPINA4(7), SRF(1), TBXA2R(1) 37381120 168 120 168 55 16 43 51 29 29 0 0.435 1.000 1.000 368 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(16), ACACB(20), ACAT2(2), ACOT12(3), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 35530493 149 119 149 58 31 26 44 29 19 0 0.822 1.000 1.000 369 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 152 118 152 57 22 40 40 26 24 0 0.575 1.000 1.000 370 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 152 118 152 57 22 40 40 26 24 0 0.575 1.000 1.000 371 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(3), GCNT2(7), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST3GAL5(6), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1) 36951387 159 118 157 61 30 37 53 18 21 0 0.456 1.000 1.000 372 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(2), CDC23(4), CDC26(1), CDC27(8), CUL1(11), CUL2(3), CUL3(14), FBXW11(3), FBXW7(34), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(3), SMURF2(6), TCEB1(2), TCEB2(1), UBA1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(1), WWP1(7), WWP2(5) 30450179 144 118 135 42 16 33 35 28 31 1 0.440 1.000 1.000 373 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(17), AR(6), ESR1(6), ESR2(1), ESRRA(5), HNF4A(7), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(2), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(8), NR2F1(3), NR2F2(9), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(5), PGR(5), PPARA(2), PPARD(1), PPARG(1), RARA(4), RARB(6), RARG(11), ROR1(9), RORA(4), RORC(3), RXRA(5), RXRB(3), RXRG(7), THRA(7), THRB(1), VDR(2) 31972831 171 118 169 50 31 30 59 25 25 1 0.130 1.000 1.000 374 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(3), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(8), PLCG2(9), PPAP2A(1), PPAP2B(1) 37943344 155 116 154 50 20 26 47 26 36 0 0.282 1.000 1.000 375 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(7), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(37), PFKL(6), PFKM(6), PFKP(6), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2) 29300594 153 116 152 39 26 34 46 22 23 2 0.0186 1.000 1.000 376 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(4), ACAT2(2), ACOX1(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(13), CYP4A22(10), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5) 37199236 150 116 150 50 15 37 41 34 23 0 0.414 1.000 1.000 377 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(8), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PIK3CB(7), PITX2(2), PLD1(17), PLD2(1), PLD3(2), VN1R1(2) 34047169 141 116 141 50 17 43 32 27 22 0 0.323 1.000 1.000 378 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(14), BAIAP2(3), CASP1(2), CASP3(2), CASP7(3), CASP8(61), GAPDH(2), INSR(3), ITCH(7), MAGI1(14), MAGI2(20), RERE(7), WWP1(7), WWP2(5) 18243627 150 113 138 37 17 34 30 25 42 2 0.0585 1.000 1.000 379 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(18), EEF1A2(3), EEF1B2(1), EEF1D(4), EEF1G(2), EEF2(5), EEF2K(6), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G3(9), EIF5(3), EIF5A(5), EIF5B(6), ETF1(3), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1) 33334084 154 112 153 40 17 35 50 28 24 0 0.174 1.000 1.000 380 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(5), EPRS(4), FARS2(4), FARSA(1), FARSB(7), GARS(1), HARS(1), HARS2(3), IARS(11), IARS2(3), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), SARS2(1), TARS(6), TARS2(4), VARS(6), VARS2(4), WARS(2), WARS2(8), YARS(7), YARS2(4) 41248531 145 111 145 38 17 30 48 29 21 0 0.117 1.000 1.000 381 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(3), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4) 32250973 149 110 149 57 25 40 40 24 20 0 0.489 1.000 1.000 382 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(4), ARHGAP4(9), ARHGAP5(10), ARHGAP6(10), ARHGEF1(9), ARHGEF11(4), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(4), PIP5K1B(9), PPP1R12B(5), ROCK1(19), TLN1(24), VCL(6) 34447041 162 110 162 63 25 36 48 34 19 0 0.863 1.000 1.000 383 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), HRAS(32), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(8), PRKCA(7), PTK2B(4), RAC1(16), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 21663863 143 109 106 30 41 20 51 18 13 0 0.00676 1.000 1.000 384 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(9), GABBR1(3), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM7(19), GRM8(23) 15909035 149 108 147 44 32 29 46 29 13 0 0.0415 1.000 1.000 385 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(5), BLVRA(3), COX10(3), COX15(4), CP(8), CPOX(1), EARS2(5), EPRS(4), FECH(1), FTMT(6), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(2), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UROD(1), UROS(4) 32129286 146 108 146 59 17 23 57 35 14 0 0.952 1.000 1.000 386 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(3), BTG1(1), CBX3(2), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(3), DNAJA1(3), EIF4G2(9), ETV6(6), G0S2(1), GFRA1(8), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(2), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(3), PPP1R3C(2), PPP2CB(3), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(2), ZFR(5) 27841024 126 107 126 42 17 24 45 23 17 0 0.708 1.000 1.000 387 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(5), ABAT(7), ACY3(3), ADSL(5), ADSS(4), ADSSL1(6), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(1), DLAT(4), DLD(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1) 28751414 135 107 135 44 19 34 43 20 19 0 0.276 1.000 1.000 388 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(3), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(5), TAF1(13), TAF10(4), TAF13(1), TAF1L(25), TAF2(8), TAF4(5), TAF4B(5), TAF5(7), TAF5L(4), TAF6(8), TAF6L(2), TAF7(2), TAF7L(5), TAF9(3), TBPL1(2), TBPL2(1) 27383127 136 104 135 46 19 31 39 24 23 0 0.660 1.000 1.000 389 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(11), C6(25), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELP(15), SELPLG(1), VCAM1(10) 18856603 140 104 139 37 13 37 41 21 28 0 0.0525 1.000 1.000 390 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(3), AOC2(5), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(3), HAL(6), HARS(1), HARS2(3), HDC(4), HEMK1(1), HNMT(2), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(2), UROC1(5) 30069281 131 103 131 36 22 34 43 17 15 0 0.0325 1.000 1.000 391 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT2(2), ACSM1(8), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(5), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(6), L2HGDH(4), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PRDX6(1), RDH11(2), RDH12(4) 30830480 142 103 142 54 17 39 46 25 15 0 0.644 1.000 1.000 392 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(2), F12(2), F13B(13), F2(3), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), LPA(16), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8), VWF(19) 26846529 148 102 147 42 15 40 44 26 23 0 0.174 1.000 1.000 393 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), FUK(3), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(5), MTMR1(1), MTMR2(5), MTMR6(4), PFKFB1(3), PFKFB2(5), PFKFB3(3), PFKFB4(1), PFKL(6), PFKM(6), PFKP(6), PGM2(3), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2) 28192307 119 102 119 36 24 27 32 22 14 0 0.108 1.000 1.000 394 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(7), POLM(2), POLQ(22), PRIM1(3), PRIM2(1), REV1(3), REV3L(25), RFC5(2) 30787268 126 102 125 31 20 29 31 20 26 0 0.0934 1.000 1.000 395 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), LALBA(1), LCT(17), MGAM(37), PFKM(6), PFKP(6), PGM1(5), PGM3(1) 24702425 124 101 123 29 20 30 34 17 21 2 0.0121 1.000 1.000 396 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(7), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(10), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), OXCT2(1), PCCA(9), PCCB(1) 32713574 129 100 128 43 16 34 34 27 18 0 0.503 1.000 1.000 397 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7) 19574300 127 100 127 61 34 17 40 21 15 0 0.734 1.000 1.000 398 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(11), BTRC(1), CCND1(4), CREBBP(40), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(1), TLE1(8), WIF1(1), WNT1(2) 22357252 144 100 139 36 18 34 36 25 29 2 0.0525 1.000 1.000 399 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(3), CDC42(4), CREB1(1), CREB3(1), CREB5(8), DUSP1(2), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(6), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK1(9), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3) 25354134 123 99 114 35 24 25 32 23 19 0 0.164 1.000 1.000 400 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(8), ADRBK2(5), ARRB2(3), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(5), CLCA2(6), CLCA4(6), CNGA3(10), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(3), PRKG1(8), PRKG2(2), PRKX(1) 23203428 120 98 120 45 18 27 35 23 17 0 0.548 1.000 1.000 401 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), NACA(25), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5) 38518834 143 97 142 52 15 38 48 18 23 1 0.848 1.000 1.000 402 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(3), CEBPB(1), DAZL(3), DMC1(2), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), NCOR1(21), NRIP1(9), PGR(5), PRLR(8), PTGER2(5), SMPD1(2), VDR(2), ZP2(6) 26643751 128 97 124 37 15 32 39 21 21 0 0.225 1.000 1.000 403 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(5), ADCY3(8), ADCY9(9), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(8), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6) 28098922 128 96 128 35 24 28 36 21 19 0 0.0589 1.000 1.000 404 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(7), ACACA(16), ACACB(20), ACADM(3), ACAT2(2), ACSS1(5), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 30167579 123 95 123 47 23 22 36 24 18 0 0.800 1.000 1.000 405 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(12), IRAK1(3), JUN(1), LY96(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(4), TLR2(3), TLR3(2), TLR4(16), TLR6(4), TLR7(8), TLR9(7), TOLLIP(2), TRAF6(3) 27776437 120 95 119 46 19 25 38 14 24 0 0.710 1.000 1.000 406 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(2), DLG4(5), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(8) 19451476 114 94 114 41 23 28 30 20 13 0 0.213 1.000 1.000 407 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 28074114 119 94 119 41 22 23 36 24 14 0 0.589 1.000 1.000 408 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 125 92 122 38 23 26 31 21 23 1 0.202 1.000 1.000 409 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 125 92 122 38 23 26 31 21 23 1 0.202 1.000 1.000 410 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(4), GIPR(2), GLP1R(2), GLP2R(3), GPR64(6), LPHN1(11), LPHN2(11), LPHN3(24), SCTR(2), VIPR1(1), VIPR2(6) 20246798 120 92 120 44 15 15 36 38 16 0 0.641 1.000 1.000 411 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BAD(2), BRAF(10), CREB1(1), CREB3(1), CREB5(8), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(6), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MAPK1(9), MKNK1(1), MKNK2(3), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), SHC1(3), SOS1(9), SOS2(11), TRAF3(6) 22423570 130 92 122 32 33 23 37 21 16 0 0.0407 1.000 1.000 412 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), GAMT(2), GATM(4), GLUD1(4), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3) 33577243 117 91 117 39 22 25 33 21 16 0 0.367 1.000 1.000 413 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(10) 22321126 115 91 114 44 15 19 43 22 15 1 0.734 1.000 1.000 414 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(5), ALAS2(5), AMT(2), AOC2(5), AOC3(5), ATP6V0C(2), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), MAOA(1), MAOB(1), PLCB2(7), PLCG1(8), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(2), TARS(6) 31847778 117 90 117 47 28 20 40 19 10 0 0.690 1.000 1.000 415 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(10), ATP4B(2), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(7), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4) 28976279 116 90 114 27 16 29 34 24 13 0 0.0248 1.000 1.000 416 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), AOX1(10), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), PCCA(9), PCCB(1), SDS(1) 27373833 108 90 107 34 11 22 32 25 18 0 0.550 1.000 1.000 417 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(7), ADC(1), ALDH5A1(1), CAD(5), CPS1(13), EARS2(5), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 30042916 109 89 109 51 19 25 26 20 19 0 0.932 1.000 1.000 418 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(7), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), MLYCD(3), SDS(1), SMS(3), UPB1(2) 22098133 114 88 114 31 12 30 38 22 12 0 0.125 1.000 1.000 419 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ATP6V0C(2), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADHA(3), PLOD1(3), PLOD2(8), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(2) 28166869 110 88 110 45 19 18 28 24 21 0 0.780 1.000 1.000 420 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(7), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 25172960 103 87 103 32 17 17 33 20 16 0 0.501 1.000 1.000 421 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(2), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(8), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 21552481 103 86 102 30 13 24 36 17 13 0 0.224 1.000 1.000 422 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(3), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(3), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(8), TAF7(2), TAF9(3), TBP(2) 26651829 112 86 112 39 9 26 28 23 26 0 0.621 1.000 1.000 423 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(5), AMT(2), AOC2(5), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SARS2(1), SDS(1), SHMT1(1), SHMT2(2), TARS(6), TARS2(4) 32368566 109 85 109 45 27 20 39 15 7 1 0.720 1.000 1.000 424 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(3), AP2M1(3), BAD(2), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PLCG1(8), PRKCE(3), PRKCZ(3), RAB5A(3), RAC1(16), RPS6KB1(5), VAV2(4) 19026716 107 85 99 31 18 21 32 16 19 1 0.179 1.000 1.000 425 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(8), DLG4(5), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(9), MAPK7(6), MAPK8(4), MYEF2(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RAF1(3), RASAL1(5), TEC(2), VAV1(8) 20902749 103 85 96 23 15 22 26 18 21 1 0.0262 1.000 1.000 426 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), COMT(2), DBH(8), DCT(4), DDC(7), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(3), TPO(11), TYR(8) 24089511 104 85 103 40 18 25 31 12 18 0 0.517 1.000 1.000 427 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), RPE(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), XYLB(3) 20775690 104 84 104 40 14 15 39 25 11 0 0.876 1.000 1.000 428 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(3), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(3) 26180325 99 84 99 44 23 20 20 17 19 0 0.801 1.000 1.000 429 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(10), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(8), VIP(1), VIPR2(6) 21280054 103 84 101 36 24 20 31 16 12 0 0.369 1.000 1.000 430 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), ALG9(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(2), RPN1(2), RPN2(6), ST6GAL1(3), STT3B(2) 32231042 113 83 113 41 15 23 38 18 19 0 0.668 1.000 1.000 431 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(17), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(4), LCAT(2), LDLR(6), LIPC(5), LPL(4), LRP1(34), SCARB1(1), SOAT1(5) 20853162 92 83 91 29 12 21 27 19 13 0 0.357 1.000 1.000 432 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(4), AGTR1(14), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), REN(3) 19141541 103 82 102 40 12 31 30 20 10 0 0.849 1.000 1.000 433 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFAT5(13), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5) 27079943 103 82 103 40 10 36 27 17 13 0 0.519 1.000 1.000 434 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(7), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HIBCH(2), MLYCD(3), SMS(3), UPB1(2) 20536304 99 81 99 29 11 30 31 19 8 0 0.167 1.000 1.000 435 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(3), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(3), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(4), WBSCR17(9) 24558538 105 80 105 38 17 28 28 15 16 1 0.604 1.000 1.000 436 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(3), AGT(4), AGTR1(14), AGTR2(2), CMA1(5), CPA3(7), CTSA(2), CTSG(1), ENPEP(14), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1) 16088430 97 80 97 33 13 18 34 20 12 0 0.443 1.000 1.000 437 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(7), CYP4F3(4), EPX(10), GGT1(4), LTA4H(1), MPO(8), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5), TPO(11) 21251910 96 79 95 46 22 18 27 11 18 0 0.849 1.000 1.000 438 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(4), ARSE(2), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD1(2), SMPD3(2), SMPD4(5), SPHK2(5), SPTLC1(5), SPTLC2(3), UGCG(1) 27239418 95 78 95 44 20 24 26 12 13 0 0.716 1.000 1.000 439 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(2), TGFB2(3), TGFB3(1), TOLLIP(2), TRAF6(3) 22629746 91 78 90 34 18 17 26 12 18 0 0.723 1.000 1.000 440 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(7), ACO2(3), CLYBL(1), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), OGDHL(12), PC(14), PCK1(1), PCK2(4), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 22686178 94 76 93 37 19 18 29 15 13 0 0.639 1.000 1.000 441 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(7), ADSL(5), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), PC(14) 19803813 89 75 89 28 15 17 30 14 13 0 0.299 1.000 1.000 442 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(8) 18450820 85 75 85 31 14 16 25 19 11 0 0.491 1.000 1.000 443 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), EPRS(4), GAMT(2), GATM(4), GLUD1(4), GLUD2(10), GOT1(1), GOT2(3), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 27312081 95 75 95 33 20 17 23 22 13 0 0.529 1.000 1.000 444 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(3), NCOA1(7), NCOA2(8), NCOA3(9), NCOR2(24), POLR2A(11), RARA(4), RXRA(5), TBP(2) 18982669 93 75 93 25 12 21 25 23 12 0 0.110 1.000 1.000 445 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(2), CYP11B1(7), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14) 20760596 89 74 89 34 18 14 27 19 11 0 0.699 1.000 1.000 446 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(7), ALDH5A1(1), CAD(5), CPS1(13), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), GMPS(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 25243521 87 74 87 41 13 21 21 17 15 0 0.933 1.000 1.000 447 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2) 24044556 89 74 89 37 17 20 28 17 7 0 0.774 1.000 1.000 448 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(7), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(2), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1) 19612415 90 73 90 32 10 26 28 12 14 0 0.553 1.000 1.000 449 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), GCK(4), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), KHK(3), MPI(5), PFKFB1(3), PFKFB3(3), PFKFB4(1), PFKM(6), PFKP(6), PMM2(2), SORD(2), TPI1(4) 18131556 80 72 80 23 14 23 18 14 11 0 0.0729 1.000 1.000 450 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(9), GNA12(2), GNA13(2), GNB1(3), MYLK(8), PLCB1(21), PPP1R12B(5), PRKCA(7), ROCK1(19) 15718096 86 71 85 30 15 16 28 16 11 0 0.653 1.000 1.000 451 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(17), AP2A1(3), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(5), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(9), SYT1(8) 16499519 81 71 81 35 11 15 27 15 13 0 0.922 1.000 1.000 452 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(4), IKBKB(12), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(16), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 18588574 83 71 82 30 15 17 26 13 12 0 0.560 1.000 1.000 453 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(5), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2) 18542350 82 70 82 24 11 18 31 12 10 0 0.183 1.000 1.000 454 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(4), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(13), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3) 22360443 80 70 80 25 18 21 22 11 8 0 0.221 1.000 1.000 455 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(6), CHIT1(4), CTBS(3), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(5), HK3(8), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(4) 21800018 82 70 82 28 21 17 21 8 15 0 0.402 1.000 1.000 456 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4) 18172097 85 70 85 30 11 16 36 12 9 1 0.498 1.000 1.000 457 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), HAL(6) 16146378 79 70 79 33 16 17 21 16 9 0 0.834 1.000 1.000 458 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), P4HB(1), SLC23A1(3), SLC23A2(7), SLC2A1(4), SLC2A3(2) 18991315 89 70 88 40 10 27 24 17 11 0 0.948 1.000 1.000 459 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(4), DARS(5), EPRS(4), FARS2(4), GARS(1), HARS(1), IARS(11), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(7) 24299185 84 69 84 21 7 14 33 21 9 0 0.231 1.000 1.000 460 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(6), ACTN2(11), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(10), PXN(3), VCL(6) 14613213 85 68 83 36 11 18 30 13 12 1 0.896 1.000 1.000 461 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(30), PLCB1(21), PPP1CA(1), PPP1R1B(2), PPP3CA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 12136445 83 67 81 30 16 21 24 18 4 0 0.337 1.000 1.000 462 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(2), TGFB2(3), TGFB3(1) 15203829 79 66 78 26 10 13 26 14 16 0 0.354 1.000 1.000 463 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(8) 15979389 73 63 73 25 15 14 22 15 7 0 0.410 1.000 1.000 464 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(7), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), METTL2B(4), METTL6(3), PAPSS1(6), PAPSS2(6), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(3) 18938494 77 62 77 23 18 21 19 12 7 0 0.132 1.000 1.000 465 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(3) 15532358 72 62 72 31 13 15 14 16 14 0 0.802 1.000 1.000 466 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(6), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7) 12508670 71 62 71 23 15 14 19 11 12 0 0.269 1.000 1.000 467 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), SELE(7), SELL(2), SELP(15) 12108439 82 62 81 29 9 18 22 12 21 0 0.525 1.000 1.000 468 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), HAL(6) 14444489 68 62 68 28 12 16 18 15 7 0 0.804 1.000 1.000 469 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3) 15543179 68 62 68 25 11 13 19 16 9 0 0.458 1.000 1.000 470 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(3), CP(8), CPOX(1), EPRS(4), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UROD(1), UROS(4) 20864118 70 62 70 35 8 11 25 17 9 0 0.987 1.000 1.000 471 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), ESCO1(4), ESCO2(4), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11) 26016506 76 61 75 37 15 16 27 7 11 0 0.924 1.000 1.000 472 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CMBL(2), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(10), PON2(1), PON3(6) 13706360 70 61 69 27 10 10 23 13 14 0 0.773 1.000 1.000 473 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), OPLAH(6) 16828021 72 61 72 31 14 18 20 13 7 0 0.610 1.000 1.000 474 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(6), CRADD(1), IKBKB(12), JUN(1), LTA(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 18415390 67 61 67 25 13 12 21 9 12 0 0.665 1.000 1.000 475 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(4), MAPK14(2), NFATC1(10), NFATC2(15), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9250727 63 60 63 25 19 13 13 9 9 0 0.324 1.000 1.000 476 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15) 15808855 64 59 64 31 14 11 23 9 7 0 0.929 1.000 1.000 477 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6) 17108010 64 59 64 22 12 14 17 7 14 0 0.448 1.000 1.000 478 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(22), CFTR(14), GNAS(12), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1) 9965823 65 58 64 19 18 14 18 9 6 0 0.236 1.000 1.000 479 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(22), GNAS(12), GNB1(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 11662340 69 58 68 22 20 11 20 10 8 0 0.481 1.000 1.000 480 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(10), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(4), QPRT(1) 16385816 70 58 70 36 9 9 23 18 11 0 0.984 1.000 1.000 481 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX2(2), PRDX6(1), TAT(1), TPO(11) 16695952 68 58 67 32 15 15 23 6 9 0 0.769 1.000 1.000 482 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(22), GNAS(12), PLCE1(21), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAP2B(2) 11244945 73 58 72 22 20 15 21 8 9 0 0.246 1.000 1.000 483 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(9), COMT(2), DBH(8), DDC(7), GAD1(4), GAD2(7), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(2) 10979411 64 57 64 28 10 13 23 5 13 0 0.739 1.000 1.000 484 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22) 12728592 61 57 61 16 11 13 14 7 16 0 0.155 1.000 1.000 485 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTAP(4), MTFMT(4), MTR(8), TAT(1) 15762418 72 57 72 25 11 16 15 14 16 0 0.343 1.000 1.000 486 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(11), ENPP6(5), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1) 17648206 76 57 76 21 6 21 23 14 12 0 0.156 1.000 1.000 487 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(8), TPI1(4) 15364646 65 57 65 23 10 14 23 11 7 0 0.519 1.000 1.000 488 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(30), MAP2(21), PPP1CA(1), PRKACB(3), PRKACG(3), PRKAR2B(3), PRKCE(3) 13782702 64 56 63 20 4 7 24 11 18 0 0.819 1.000 1.000 489 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(10), CR2(9), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19) 11557965 64 56 63 29 4 17 17 10 16 0 0.910 1.000 1.000 490 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(6), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2), VNN1(3) 13169729 71 56 71 29 8 15 23 16 9 0 0.823 1.000 1.000 491 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(4), ARSE(2), ASAH1(1), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD1(2), SPTLC1(5), SPTLC2(3), UGCG(1) 18358974 63 55 63 33 14 16 17 6 10 0 0.894 1.000 1.000 492 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(9), ABCG2(4), BCHE(5), CES1(7), CES2(11), CYP3A4(6), CYP3A5(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1) 17365735 66 55 66 35 13 10 26 9 8 0 0.951 1.000 1.000 493 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(16), CPT1A(6), LEP(1), LEPR(20), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2) 10992549 59 55 59 30 9 8 21 9 12 0 0.989 1.000 1.000 494 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), SOAT2(2) 17667332 65 54 65 27 10 11 20 15 9 0 0.842 1.000 1.000 495 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(8), F2(3), F2R(4), FGA(10), FGB(4), FGG(6), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8) 10177414 68 54 68 24 6 17 18 9 18 0 0.669 1.000 1.000 496 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(7), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), HADHA(3), SH3GLB1(2), YOD1(4) 23523236 65 54 65 27 3 14 22 17 9 0 0.874 1.000 1.000 497 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1) 17836859 71 54 71 21 6 16 20 13 16 0 0.351 1.000 1.000 498 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(2), IL22RA1(4), IL22RA2(1), JAK1(11), JAK2(5), JAK3(6), SOCS3(1), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8) 13969727 64 54 64 26 8 19 18 10 9 0 0.527 1.000 1.000 499 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), RAC1(16), WASF1(3), WASF2(5), WASF3(7), WASL(2) 11577433 62 53 55 22 16 14 14 12 6 0 0.637 1.000 1.000 500 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(4), IARS(11), IARS2(3), ILVBL(6), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(6), VARS2(4) 14172257 64 53 64 23 3 24 21 7 9 0 0.571 1.000 1.000 501 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(7), ST3GAL6(4), ST8SIA1(3) 12353169 57 53 55 20 9 15 23 5 5 0 0.356 1.000 1.000 502 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(2), ATIC(6), DHFR(3), FTCD(3), GART(4), MTFMT(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 14376024 64 53 64 24 9 6 25 10 13 1 0.762 1.000 1.000 503 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(4), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), GAMT(2), GATM(4), GLUD1(4), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3) 13320479 55 53 55 16 15 15 14 7 4 0 0.152 1.000 1.000 504 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(6), IFNG(2), IKBKB(12), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2) 14780390 60 52 60 20 9 9 21 7 14 0 0.624 1.000 1.000 505 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(3), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(14), PCK1(1), SDHA(7), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 15649727 61 52 60 22 10 16 18 10 7 0 0.413 1.000 1.000 506 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(11), EGF(9), EGFR(21), HGS(2), RAB5A(3), TF(5), TFRC(7) 9752921 58 52 58 21 5 13 17 12 10 1 0.764 1.000 1.000 507 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), PHPT1(1), TYR(8) 11427331 59 52 59 18 11 6 24 7 11 0 0.641 1.000 1.000 508 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), GOSR1(4), GOSR2(2), SNAP25(3), STX11(6), STX12(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1) 12701549 59 52 58 18 11 13 17 4 14 0 0.320 1.000 1.000 509 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3) 13818226 55 51 55 18 10 12 15 5 13 0 0.472 1.000 1.000 510 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(2) 16075307 59 51 59 27 8 8 27 11 5 0 0.952 1.000 1.000 511 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8) 14191291 60 51 60 23 5 13 18 8 16 0 0.772 1.000 1.000 512 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), JAK1(11), PTPRU(9), REG1A(13), STAT1(7), STAT2(6), TYK2(8) 9506297 57 51 57 22 9 15 15 7 11 0 0.550 1.000 1.000 513 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD5(1), CD7(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(7), TLR2(3), TLR4(16), TLR7(8), TLR9(7) 14151845 59 50 59 25 9 12 17 9 12 0 0.660 1.000 1.000 514 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), PGD(2) 13740469 58 50 58 22 13 14 14 10 7 0 0.470 1.000 1.000 515 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(16), ACACB(20), FASN(10), MCAT(3), OLAH(3), OXSM(3) 12070202 55 49 55 23 13 12 14 11 5 0 0.658 1.000 1.000 516 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(20), ABCB11(9), ABCB4(13), ABCC1(5), ABCC3(4), GSTP1(1) 10885488 52 49 52 24 7 10 18 3 14 0 0.806 1.000 1.000 517 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(2), ATIC(6), ATP6V0C(2), DHFR(3), GART(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 13581168 59 49 59 25 9 5 26 9 9 1 0.894 1.000 1.000 518 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(32), MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1) 5716600 55 49 32 19 9 11 23 9 3 0 0.456 1.000 1.000 519 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPHN(5), NSF(1), UBQLN1(2) 9111054 58 48 57 26 5 11 21 9 12 0 0.953 1.000 1.000 520 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4) 10912235 54 48 54 23 11 14 12 10 7 0 0.644 1.000 1.000 521 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELE(7), SELL(2) 9205718 59 48 58 23 7 14 14 8 16 0 0.634 1.000 1.000 522 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2) 10610737 58 48 58 22 7 10 19 14 8 0 0.775 1.000 1.000 523 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(21), PLCB2(7), PRL(4), TRH(2), VIP(1) 8460897 52 48 51 23 6 7 24 10 5 0 0.844 1.000 1.000 524 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPX1(3), PRKCE(3), SOD1(1) 5981221 55 47 54 19 5 8 22 8 12 0 0.743 1.000 1.000 525 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTR(8) 13211457 59 47 59 23 10 14 13 12 10 0 0.518 1.000 1.000 526 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(5), HK3(8), PGM3(1), RENBP(5), UAP1(4) 12878816 48 46 48 16 13 14 9 6 6 0 0.352 1.000 1.000 527 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(4), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGW(2), PIGX(2), PIGZ(2) 18076612 53 46 53 32 8 13 16 6 10 0 0.989 1.000 1.000 528 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14) 13372374 49 46 49 25 9 4 15 15 6 0 0.963 1.000 1.000 529 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(3), LCT(17), MPI(5), PGM1(5), PYGL(9), PYGM(8), TPI1(4), TREH(1) 10134954 56 45 56 19 10 15 16 8 7 0 0.263 1.000 1.000 530 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 15482055 50 45 50 25 15 8 12 6 9 0 0.825 1.000 1.000 531 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(3), AFMID(6), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 10171935 51 45 51 16 6 13 17 8 6 1 0.483 1.000 1.000 532 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(3), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(2), SLC25A20(3) 12775859 51 45 51 20 5 13 11 12 10 0 0.762 1.000 1.000 533 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(5), GALNT2(7), GALNT3(6), GALNT6(4), GALNT7(3), GALNT8(6), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(9) 10976813 47 44 47 20 8 14 12 5 7 1 0.699 1.000 1.000 534 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4) 13746524 49 43 49 18 9 10 16 9 5 0 0.565 1.000 1.000 535 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(5), AOC3(5), CES1(7), DDHD1(5), ESCO1(4), ESCO2(4), LIPA(3), PLA1A(8), PRDX6(1), SH3GLB1(2) 19292782 49 43 49 12 4 12 19 9 5 0 0.268 1.000 1.000 536 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(10), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5E(1), QPRT(1) 11070058 51 43 51 27 4 7 19 13 8 0 0.981 1.000 1.000 537 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(3), FOS(6), JUN(1), OPRK1(7), POLR2A(11), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9805793 45 42 45 17 9 12 12 7 5 0 0.497 1.000 1.000 538 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(9), EGFR(21), ERBB3(14), NRG1(4) 7831161 48 42 48 17 5 12 12 13 5 1 0.686 1.000 1.000 539 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(8), IRS1(4), JAK1(11), JAK3(6), RPS6KB1(5), SHC1(3), STAT6(5) 11221458 45 42 45 13 7 11 12 8 7 0 0.220 1.000 1.000 540 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(3) 15241478 55 42 55 18 9 9 15 9 13 0 0.448 1.000 1.000 541 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(4), DHFR(3), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(1) 9527178 46 42 46 16 12 5 18 2 9 0 0.554 1.000 1.000 542 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD8A(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8175122 45 42 45 22 4 8 10 9 14 0 0.872 1.000 1.000 543 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(4), AGTR1(14), AGTR2(2), BDKRB2(3), KNG1(5), NOS3(4), REN(3) 7503265 43 41 43 17 7 12 11 8 5 0 0.485 1.000 1.000 544 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(5), ARFGEF2(14), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(3) 12328265 47 41 47 14 5 17 12 4 9 0 0.219 1.000 1.000 545 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(3), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 9711714 45 41 45 16 6 10 16 7 5 1 0.666 1.000 1.000 546 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(6), GREB1(19), HSPB2(2), MTA1(8), MTA3(2), PDZK1(1), TUBA8(2) 8345615 46 41 46 22 12 3 17 8 6 0 0.852 1.000 1.000 547 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8577979 44 41 44 22 3 8 10 10 13 0 0.885 1.000 1.000 548 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(5), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2), VKORC1(2) 14668829 45 40 45 18 11 11 10 5 8 0 0.577 1.000 1.000 549 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(5), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1) 9584644 48 40 48 22 20 8 14 2 4 0 0.728 1.000 1.000 550 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(2), YOD1(4) 19773448 44 40 44 16 2 11 12 12 7 0 0.675 1.000 1.000 551 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 12562163 43 39 43 21 12 6 12 6 7 0 0.829 1.000 1.000 552 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(10), MPO(8), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8827971 42 38 41 22 15 6 15 3 3 0 0.892 1.000 1.000 553 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(6) 12149192 43 38 43 15 3 8 16 11 5 0 0.710 1.000 1.000 554 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(2), CAT(4), EPX(10), MPO(8), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8975989 44 38 43 21 14 6 16 5 3 0 0.830 1.000 1.000 555 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), FDXR(4), SHMT1(1) 12146771 50 38 50 14 6 9 18 9 8 0 0.375 1.000 1.000 556 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(5), SELL(2), SPN(3), TGFB1(2), TGFB2(3), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10031334 43 38 43 19 6 12 11 10 4 0 0.658 1.000 1.000 557 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(3), PER3(7) 12977866 44 37 44 17 11 11 10 9 3 0 0.573 1.000 1.000 558 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(2), IL1A(1), IL6(2), JAK1(11), STAT1(7), STAT3(6), STAT5A(3) 9254119 41 37 41 20 3 15 11 6 6 0 0.651 1.000 1.000 559 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), JAK2(5), STAT4(6), TYK2(8) 11170748 45 37 45 19 4 10 14 7 10 0 0.789 1.000 1.000 560 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), TYR(8) 7388664 41 37 41 14 5 6 19 4 7 0 0.699 1.000 1.000 561 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(2), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 11090459 37 37 36 13 4 9 12 1 11 0 0.598 1.000 1.000 562 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(3), RPL8(1), RPS13(2), RPS15A(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS28(1), RPS3(1), RPS5(1) 17258755 45 36 45 21 5 10 17 4 9 0 0.879 1.000 1.000 563 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(4), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), TBXA2R(1) 8514322 41 36 41 22 8 8 17 5 3 0 0.770 1.000 1.000 564 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 565 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 566 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(5), GPR161(4), GPR171(3), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(3), GPR75(5) 7484334 38 35 38 19 11 7 7 7 6 0 0.857 1.000 1.000 567 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1) 9523891 40 35 40 16 8 5 15 7 5 0 0.752 1.000 1.000 568 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 18987938 41 35 41 16 3 12 8 10 8 0 0.754 1.000 1.000 569 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(5), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(4) 8603698 38 35 38 12 6 11 10 6 5 0 0.430 1.000 1.000 570 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), RAC1(16), WASF1(3), WASL(2) 6161554 37 35 30 15 11 9 7 7 3 0 0.734 1.000 1.000 571 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(10), MPO(8), PRDX2(2), PRDX6(1), TPO(11), TYR(8) 7343191 40 35 39 18 11 4 17 4 4 0 0.818 1.000 1.000 572 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 573 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1) 7603533 41 35 41 13 0 16 14 6 5 0 0.622 1.000 1.000 574 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNAR2(3), JAK1(11), STAT1(7), STAT2(6), TYK2(8) 8257040 38 34 38 16 5 11 7 6 9 0 0.673 1.000 1.000 575 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RELA(2) 6273776 36 34 35 12 5 6 15 6 4 0 0.519 1.000 1.000 576 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 577 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 578 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6) 5331209 37 33 37 19 4 10 15 4 4 0 0.874 1.000 1.000 579 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1) 8797320 34 33 34 14 3 9 10 4 8 0 0.895 1.000 1.000 580 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), EPO(2), EPOR(2), GRIN1(4), HIF1A(3), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1) 9657990 33 33 33 11 4 11 6 7 5 0 0.358 1.000 1.000 581 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 9244748 36 33 36 13 4 5 12 9 6 0 0.703 1.000 1.000 582 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(7), ITGAM(8), ITGB2(4), SELE(7), SELL(2) 7886915 37 33 37 21 4 9 7 5 12 0 0.895 1.000 1.000 583 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(10), PON2(1), PON3(6), RDH11(2), RDH12(4) 6840643 37 32 36 17 3 7 11 11 5 0 0.830 1.000 1.000 584 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), LTA(4), TGFB1(2), TGFB2(3), TGFB3(1) 10113759 34 32 33 18 5 8 7 8 6 0 0.931 1.000 1.000 585 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(19), ZAP70(2) 6869407 36 32 35 18 3 8 8 7 10 0 0.907 1.000 1.000 586 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3) 10054416 33 31 33 14 4 8 8 8 5 0 0.777 1.000 1.000 587 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(3), GGT1(4), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(1) 9404841 33 31 33 12 8 10 7 6 2 0 0.443 1.000 1.000 588 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 32 30 32 15 10 3 8 5 5 1 0.837 1.000 1.000 589 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 32 30 32 15 10 3 8 5 5 1 0.837 1.000 1.000 590 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(10), GBA(3), MPO(8), PRDX6(1), TPO(11) 6371299 33 29 32 16 11 5 12 2 3 0 0.804 1.000 1.000 591 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7) 6487339 30 28 30 11 6 6 8 9 1 0 0.632 1.000 1.000 592 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(7), ACO2(3), ACSS1(5), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(1) 10104755 32 28 32 16 3 10 11 2 6 0 0.865 1.000 1.000 593 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(2), FH(3), IDH2(1), MDH1(1), OGDH(11), SDHA(7), SUCLA2(1) 7148129 29 27 28 10 5 4 11 5 4 0 0.657 1.000 1.000 594 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4) 10028443 28 25 28 12 9 8 3 4 4 0 0.564 1.000 1.000 595 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3) 6074660 25 24 25 11 4 2 9 6 4 0 0.853 1.000 1.000 596 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3) 6074660 25 24 25 11 4 2 9 6 4 0 0.853 1.000 1.000 597 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4), VKORC1(2) 8415959 27 24 27 10 10 8 3 2 4 0 0.361 1.000 1.000 598 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6) 7528437 26 24 26 13 5 6 7 4 4 0 0.819 1.000 1.000 599 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 9007518 30 24 30 11 0 11 10 5 4 0 0.716 1.000 1.000 600 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(2), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1) 10918791 26 24 26 16 6 8 5 2 5 0 0.893 1.000 1.000 601 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(3), FARS2(4), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7) 6306436 29 24 29 11 0 9 11 3 6 0 0.603 1.000 1.000 602 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), DHFR(3), FPGS(2), GGH(3) 4978860 25 23 25 11 3 2 13 3 4 0 0.769 1.000 1.000 603 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3) 7706334 25 22 25 14 4 6 8 1 6 0 0.893 1.000 1.000 604 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(4) 5101404 22 22 22 10 5 4 9 3 1 0 0.655 1.000 1.000 605 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(13), GLS(1), GLUD1(4), GOT1(1) 5928982 22 22 22 10 4 5 5 5 3 0 0.801 1.000 1.000 606 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 5250461 24 21 24 17 7 3 7 2 4 1 0.960 1.000 1.000 607 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(2), TGFB2(3), TGFB3(1) 6285319 23 20 23 12 6 2 8 5 2 0 0.882 1.000 1.000 608 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), NAT1(2), XDH(6) 6066385 23 20 23 13 3 5 9 4 2 0 0.906 1.000 1.000 609 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(5), CPO(4), FECH(1), HBA2(2), UROD(1), UROS(4) 5939473 19 19 19 11 2 3 7 6 1 0 0.947 1.000 1.000 610 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), IL9(2) 4619492 18 18 18 10 4 3 6 3 2 0 0.888 1.000 1.000 611 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 12617181 18 17 18 10 0 4 5 5 4 0 0.957 1.000 1.000 612 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4) 6712693 19 16 19 10 3 6 5 2 3 0 0.957 1.000 1.000 613 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4) 2979765 16 16 16 7 1 6 4 5 0 0 0.692 1.000 1.000 614 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4) 6833447 17 16 17 11 3 2 4 4 4 0 0.969 1.000 1.000 615 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4) 3644574 16 15 16 7 3 3 7 3 0 0 0.695 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(6), SUCLA2(1) 1601806 7 7 7 4 0 2 4 1 0 0 0.831 1.000 1.000