rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(5), CDC34(4), CUL1(11), RB1(18), TFDP1(3) 4986845 41 35 41 7 3 12 6 3 17 0 0.0381 0.264 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 386575 2 2 2 0 0 0 0 0 2 0 0.660 0.300 1.000 3 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 4644911 24 22 24 2 5 7 5 5 2 0 0.0310 0.501 1.000 4 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 549130 2 2 2 1 1 0 0 1 0 0 0.796 0.574 1.000 5 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(6) 1383171 9 9 9 2 1 3 2 2 1 0 0.347 0.623 1.000 6 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(7) 1537915 13 13 13 3 0 4 5 3 1 0 0.369 0.674 1.000 7 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(2), RAB27A(1), RAB3A(2), RAB4A(1), RAB5A(3) 3208378 14 14 14 1 5 4 2 2 1 0 0.0336 0.685 1.000 8 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(4), UXS1(2) 2921501 11 11 11 0 0 1 5 4 1 0 0.104 0.695 1.000 9 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(4) 1256585 6 6 6 2 1 3 2 0 0 0 0.649 0.717 1.000 10 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(10), BCMO1(3), RDH5(1) 2966657 15 15 15 3 2 1 6 2 4 0 0.357 0.778 1.000 11 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(4), UGP2(2), UXS1(2) 3720453 13 13 13 0 0 1 7 4 1 0 0.0736 0.792 1.000 12 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2) 1800404 7 7 6 2 0 1 0 3 3 0 0.747 0.810 1.000 13 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(18), SP1(3), SP3(3) 5049097 26 26 26 9 0 2 5 4 15 0 0.839 0.811 1.000 14 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(1), RXRA(5) 4399391 16 16 16 1 2 4 6 2 2 0 0.0307 0.837 1.000 15 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 1694316 7 7 7 2 1 3 2 0 1 0 0.481 0.845 1.000 16 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CHEK1(1), NEK1(9), WEE1(1) 5221484 17 17 17 1 4 3 6 1 3 0 0.124 0.864 1.000 17 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(1), GRIA2(16), JUND(1), PPP1R1B(2) 2839623 23 22 23 6 4 6 11 2 0 0 0.219 0.892 1.000 18 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(5), SNCA(1), SNCAIP(3), UBE2L3(2), UBE2L6(2) 4889898 23 21 23 4 4 5 4 7 3 0 0.155 0.912 1.000 19 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(6), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2) 2305423 12 12 11 4 0 4 4 0 4 0 0.598 0.953 1.000 20 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1160551 1 1 1 0 0 0 0 1 0 0 0.757 0.955 1.000 21 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(1), IL12B(4), IL18(1), IL2(2) 2267286 12 12 12 4 1 2 2 4 3 0 0.769 0.963 1.000 22 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(4), PRKCA(7), TGM2(4) 3760452 18 18 18 4 2 6 5 3 2 0 0.114 0.965 1.000 23 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(5), CES1(7), ESD(3) 4600242 20 19 20 3 2 9 7 0 2 0 0.0470 0.972 1.000 24 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(5) 3898124 16 15 16 3 4 3 6 2 1 0 0.151 0.973 1.000 25 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 860420 1 1 1 1 0 0 1 0 0 0 0.944 0.975 1.000 26 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(5), GAD1(4), GAD2(7), GGT1(4) 4376205 24 24 24 5 4 7 6 2 5 0 0.117 0.980 1.000 27 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(16), C5(11), C7(12), C8A(8), C9(15) 8096275 62 53 61 12 10 19 21 9 3 0 0.0301 0.983 1.000 28 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(12), RB1(18), WEE1(1), YWHAH(2) 12721311 65 59 65 9 7 14 14 8 22 0 0.0329 0.985 1.000 29 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(7), ELK1(2), FOS(6), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(2), PIK3R1(10), PLCG1(8), RAF1(3), SHC1(3), SOS1(9) 12509890 62 56 62 9 11 9 23 6 13 0 0.0152 0.986 1.000 30 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2) 6634572 26 24 26 4 1 5 8 7 5 0 0.138 0.986 1.000 31 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4) 1300338 4 4 4 3 0 1 2 0 1 0 0.872 0.991 1.000 32 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(6), FOSL1(3), FOSL2(10), IFNAR1(3), IFNAR2(3), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3) 8440356 43 40 43 8 6 9 10 9 9 0 0.185 0.991 1.000 33 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 3683426 12 10 12 2 0 4 3 3 2 0 0.269 0.991 1.000 34 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(4), CHST12(5), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 7044363 40 37 40 7 10 7 11 8 4 0 0.0562 0.992 1.000 35 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1) 6032901 24 21 24 4 7 3 7 2 5 0 0.150 0.993 1.000 36 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(22), GNAS(12), GNB1(3), PRKACA(4), PRKAR1A(3) 5046187 44 37 43 8 15 7 13 6 3 0 0.0443 0.993 1.000 37 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 4111521 14 14 14 3 2 3 4 4 1 0 0.357 0.994 1.000 38 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(4) 4058542 23 21 23 6 2 1 11 1 8 0 0.437 0.994 1.000 39 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(2), HMGCL(1), OXCT1(2) 2569006 5 5 5 2 1 0 1 1 2 0 0.781 0.994 1.000 40 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(3), TAT(1) 1997140 5 5 5 2 0 0 3 1 1 0 0.768 0.996 1.000 41 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(3), AASS(3), KARS(3) 3583040 12 12 12 3 1 1 2 3 5 0 0.515 0.996 1.000 42 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4) 4282569 14 13 14 4 1 4 2 3 4 0 0.561 0.997 1.000 43 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(1), SPCS1(2), SPCS3(1) 2321334 6 6 6 4 0 2 1 0 3 0 0.848 0.998 1.000 44 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(3), CASP3(2), CASP9(1), GZMB(2), JUN(1), PRF1(4) 8920640 38 35 38 7 6 8 4 12 8 0 0.146 0.998 1.000 45 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(3), STX1A(6) 2472973 9 9 9 3 5 0 3 1 0 0 0.647 0.999 1.000 46 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1) 5938441 17 16 17 3 2 4 5 4 2 0 0.219 0.999 1.000 47 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4) 6158075 34 32 34 9 5 8 12 6 3 0 0.286 0.999 1.000 48 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2) 2757273 18 14 18 6 1 8 5 2 2 0 0.389 0.999 1.000 49 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(6), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(5) 4142702 22 21 21 6 4 6 6 2 4 0 0.296 0.999 1.000 50 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(1), CD80(5), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1) 3017930 15 15 14 5 0 4 4 4 3 0 0.664 0.999 1.000 51 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(5), SEC61A2(4), SRP54(2), SRP68(4), SRP72(1), SRPR(2) 5730942 18 17 18 3 2 9 6 1 0 0 0.145 0.999 1.000 52 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1) 3251066 9 9 9 3 2 5 1 1 0 0 0.406 0.999 1.000 53 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(3), CD3D(1), CD80(5), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3R1(10), PTPN11(2) 8051580 39 33 38 7 0 8 8 9 14 0 0.133 0.999 1.000 54 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(1), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PRKCA(7) 4449572 21 19 21 6 1 6 6 3 5 0 0.364 0.999 1.000 55 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(5), CDC34(4), CUL1(11), RB1(18), SKP2(4), TFDP1(3) 6468191 52 45 52 13 4 12 13 5 18 0 0.217 1.000 1.000 56 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(6), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2) 4052954 19 19 18 6 1 5 8 2 3 0 0.535 1.000 1.000 57 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(6), CD3D(1), CD4(1), CD58(2), CD8A(2), IL3(1), IL6(2), KITLG(1) 4699278 17 16 17 6 2 2 3 4 6 0 0.695 1.000 1.000 58 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(4), GLUD2(10) 3468502 17 17 17 6 4 2 4 3 4 0 0.686 1.000 1.000 59 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(6), CTH(3), MUT(5) 3728828 18 17 18 5 2 6 4 3 3 0 0.473 1.000 1.000 60 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(2), IDI1(1) 2430488 7 7 7 3 2 4 1 0 0 0 0.550 1.000 1.000 61 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(8) 3576674 20 18 20 6 2 3 10 1 4 0 0.520 1.000 1.000 62 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(1) 3047233 15 14 15 5 2 3 5 2 3 0 0.600 1.000 1.000 63 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(5), JAK1(11), JAK2(5), STAT1(7) 6222329 34 30 33 9 2 9 9 5 9 0 0.242 1.000 1.000 64 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(7), ELK1(2), FOS(6), INSR(3), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SLC2A4(4), SOS1(9), SRF(1) 15828483 64 57 64 9 8 11 21 10 14 0 0.00614 1.000 1.000 65 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3) 7710747 36 34 36 8 6 7 13 4 6 0 0.102 1.000 1.000 66 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(22), CREM(3), FHL5(5), FSHB(2), FSHR(12), GNAS(12), XPO1(6) 7305896 62 53 61 12 14 12 19 14 3 0 0.0687 1.000 1.000 67 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(7), SDHB(1), SDHC(1), UQCRC1(1) 5030336 17 17 16 4 1 5 6 4 1 0 0.336 1.000 1.000 68 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(3), CD3D(1), CD4(1) 2438429 5 5 5 3 0 0 1 3 1 0 0.904 1.000 1.000 69 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(3), HTR2C(3), PLCB1(21), TUB(3) 5432569 30 30 29 8 7 5 12 5 1 0 0.293 1.000 1.000 70 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1) 6350763 18 16 18 4 1 3 8 4 2 0 0.416 1.000 1.000 71 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDKN1B(3), CKS1B(4), CUL1(11), NEDD8(2), RB1(18), RBX1(3), SKP2(4), TFDP1(3), UBE2M(2) 6508770 55 51 55 14 4 13 12 6 20 0 0.202 1.000 1.000 72 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(6), FYN(5), JUN(1), MAPK14(2), THBS1(8) 5637356 26 24 26 7 3 7 5 7 4 0 0.239 1.000 1.000 73 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(3) 5282395 17 17 17 5 1 1 3 6 6 0 0.603 1.000 1.000 74 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3) 8183514 37 35 37 9 6 7 14 4 6 0 0.137 1.000 1.000 75 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3) 5283313 15 14 15 3 3 5 5 1 1 0 0.283 1.000 1.000 76 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3) 7766709 32 31 32 7 7 10 8 3 4 0 0.0943 1.000 1.000 77 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(22), NRG2(6), NRG3(17), PRKCA(7) 6834830 57 52 57 15 4 9 22 12 10 0 0.371 1.000 1.000 78 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(6), ST6GALNAC2(3), ST8SIA1(3) 4298913 20 19 20 7 4 4 5 2 5 0 0.426 1.000 1.000 79 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(2) 4604224 22 22 22 8 3 2 11 1 5 0 0.649 1.000 1.000 80 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(12), WEE1(1), YWHAH(2) 10453443 42 37 42 7 7 9 11 8 7 0 0.120 1.000 1.000 81 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(4), GH1(4), GHR(8), IGF1(1), IGF1R(13), PIK3R1(10), SHC1(3), SOD1(1), SOD2(1), SOD3(3) 8126349 50 43 50 11 10 12 14 9 5 0 0.0867 1.000 1.000 82 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 16 IL18(1), ITGB1(17), KLRC1(1), KLRC2(1), KLRC3(4), LAT(3), MAP2K1(5), PAK1(3), PIK3R1(10), PTK2B(4), PTPN6(3), SYK(8), VAV1(8) 11388222 68 56 67 12 14 9 15 9 21 0 0.0420 1.000 1.000 83 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT2(2), FUT9(11), GCNT2(7), ST8SIA1(3) 4694960 26 25 25 9 4 6 13 2 1 0 0.464 1.000 1.000 84 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(2), GGT1(4), SHMT1(1), SHMT2(2) 3159906 9 8 9 4 3 0 4 1 1 0 0.730 1.000 1.000 85 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6) 6560593 22 22 22 5 6 5 3 5 3 0 0.322 1.000 1.000 86 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(4), OAT(1), PRODH(1) 4210897 8 8 8 3 0 2 1 3 2 0 0.659 1.000 1.000 87 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 10663831 47 41 47 9 11 11 13 6 6 0 0.0430 1.000 1.000 88 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 89 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 90 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(10), PDXK(1), PSAT1(1) 3686452 12 10 12 5 1 2 1 6 2 0 0.766 1.000 1.000 91 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(6), DNAJC3(2), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2) 6848557 24 23 24 9 4 5 5 3 7 0 0.753 1.000 1.000 92 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(3), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1) 6763942 22 19 22 5 2 8 9 1 2 0 0.223 1.000 1.000 93 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(40), GZMA(2), GZMB(2), HMGB2(2), PRF1(4), SET(1) 8072642 53 44 52 13 10 8 13 11 10 1 0.145 1.000 1.000 94 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(10), PLCB1(21), PLCG1(8), PRKCA(7), VAV1(8) 8080811 56 50 55 13 7 9 22 8 10 0 0.228 1.000 1.000 95 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(7), ELK1(2), FOS(6), IGF1(1), IGF1R(13), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1) 15296528 71 62 71 11 12 13 22 11 13 0 0.00672 1.000 1.000 96 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9) 7011957 32 29 32 9 6 8 10 6 2 0 0.240 1.000 1.000 97 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(25), CDC25C(4), CHEK1(1), CHEK2(5), YWHAH(2) 11536354 53 48 53 9 4 16 10 14 9 0 0.120 1.000 1.000 98 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(5), TAX1BP3(1), UBE2D2(1), UBE2D3(1), UBE2E1(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(2), UBE2S(1), UBE3A(6) 8012959 29 27 29 8 4 11 8 0 6 0 0.326 1.000 1.000 99 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1B(4), BMPR2(6) 4760347 15 15 15 6 3 4 4 1 3 0 0.729 1.000 1.000 100 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIK(1), BIRC2(2), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), DIABLO(2) 9317945 39 35 39 8 7 13 5 6 8 0 0.113 1.000 1.000 101 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(12), BAD(2), BAK1(1), BAX(2), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(7) 8316255 33 31 33 8 7 9 6 5 6 0 0.341 1.000 1.000 102 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1) 6441487 24 21 24 6 1 4 10 7 2 0 0.383 1.000 1.000 103 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(5), ITPKB(5) 4610024 11 9 11 4 1 3 4 1 2 0 0.609 1.000 1.000 104 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C9(15) 11866188 77 65 76 17 12 27 24 10 4 0 0.0217 1.000 1.000 105 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 6 CREBBP(40), LPL(4), NCOA1(7), NCOA2(8), PPARG(1), RXRA(5) 10308805 65 51 64 14 7 13 19 15 10 1 0.0953 1.000 1.000 106 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(1), RANBP2(14), RANGAP1(1) 6414010 18 18 18 9 3 4 5 1 5 0 0.941 1.000 1.000 107 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(2) 4542113 23 21 22 9 4 7 8 2 2 0 0.333 1.000 1.000 108 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 13 CUZD1(3), FOS(6), JUN(1), MAP2K1(5), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RAF1(3), RELA(2) 11000650 60 56 57 15 8 13 24 8 7 0 0.0830 1.000 1.000 109 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), IL6(2), IL6R(5), IL6ST(4), JAK1(11), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT3(6) 17770774 79 70 79 13 13 12 26 16 12 0 0.00567 1.000 1.000 110 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(5), DLL1(5), FURIN(1) 3958653 11 11 11 5 3 3 2 1 2 0 0.738 1.000 1.000 111 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6) 9796477 37 32 37 8 1 8 14 10 4 0 0.229 1.000 1.000 112 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), WT1(3) 4746761 17 17 15 7 0 4 8 3 2 0 0.770 1.000 1.000 113 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(12), ATM(16), BAX(2), BCL2(1), CCND1(4), CCNE1(5), CDK4(5), GADD45A(1), MDM2(2), PCNA(1), RB1(18) 13151754 67 60 67 13 4 17 10 13 23 0 0.105 1.000 1.000 114 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(2), MDH1(1), ME1(2), PC(14), PDHA1(4) 7057566 27 27 27 8 4 7 6 5 5 0 0.331 1.000 1.000 115 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(2), CCL2(2), CXCL12(6), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(8), PRKCA(7), PTK2B(4), SYT1(8) 10487659 55 49 55 13 8 9 21 13 4 0 0.105 1.000 1.000 116 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NFS1(1), PHPT1(1), TPK1(3) 4868352 16 14 16 5 4 2 5 3 2 0 0.699 1.000 1.000 117 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C9(15), MASP1(9), MASP2(5), MBL2(2) 14759177 93 74 91 21 15 29 25 16 8 0 0.0178 1.000 1.000 118 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(8), MDM2(2), MYC(6), PIK3R1(10), POLR1A(10), POLR1B(4), POLR1C(3), RB1(18), TBX2(4), TWIST1(1) 12367648 66 58 63 14 6 10 13 11 26 0 0.149 1.000 1.000 119 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(4), JAK1(11), JAK2(5), PLA2G2A(2), PTPRU(9), REG1A(13), STAT1(7) 8690684 54 48 53 14 8 16 13 7 10 0 0.108 1.000 1.000 120 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), BAD(2), CASP9(1), CHUK(6), GH1(4), GHR(8), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3R1(10), RELA(2), YWHAH(2) 9069885 47 41 46 11 5 12 12 7 11 0 0.212 1.000 1.000 121 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(11), EPHB1(16), FYN(5), ITGA1(4), ITGB1(17), L1CAM(10), LYN(8), RAP1B(3), SELP(15) 12007305 93 66 91 20 13 17 25 18 20 0 0.0671 1.000 1.000 122 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(2), IL6(2), LDLR(6), LPL(4) 4042609 16 16 15 7 2 5 6 2 1 0 0.708 1.000 1.000 123 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 13 AKT1(2), CREB1(1), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), NTRK1(3), PIK3R1(10), PLCG1(8), RPS6KA1(10), SHC1(3) 11207042 52 46 52 10 11 9 13 11 8 0 0.0766 1.000 1.000 124 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8) 9615390 56 49 54 14 4 10 18 8 16 0 0.215 1.000 1.000 125 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(5), CREB1(1), CREBBP(40), NCOA3(9), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RARA(4), RXRA(5) 11954119 80 65 79 21 15 19 16 13 16 1 0.121 1.000 1.000 126 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(3), GGT1(4), SHMT1(1), SHMT2(2) 4189992 11 11 11 5 5 2 2 1 1 0 0.639 1.000 1.000 127 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(2), PRKACB(3), PRKACG(3), PRKAR2B(3) 7645574 27 25 27 8 5 10 6 3 3 0 0.393 1.000 1.000 128 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(2), IL1B(1), MST1(7), MST1R(8) 4955041 20 19 20 9 4 6 8 0 2 0 0.612 1.000 1.000 129 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(2), OXCT2(1) 5469959 13 12 13 8 3 2 2 4 2 0 0.925 1.000 1.000 130 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(8), GLI2(15), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3) 12661824 70 62 69 17 13 17 24 8 8 0 0.0678 1.000 1.000 131 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(22), ARHGEF1(9), F2(3), F2R(4), F2RL3(3), GNA12(2), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3R1(10), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2B(4), ROCK1(19) 18014302 124 100 121 26 21 24 40 23 16 0 0.00970 1.000 1.000 132 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(2), BCAR1(3), CDKN1B(3), ILK(4), ITGB1(17), PDK2(1), PDPK1(4), PIK3R1(10), PTK2(10), SHC1(3), SOS1(9) 11921381 66 56 64 15 9 13 17 9 18 0 0.169 1.000 1.000 133 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 19 F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), ITGA1(4), ITGB1(17), MAP2K1(5), PLA2G4A(3), PLCB1(21), PRKCA(7), PTGS1(7), PTK2(10), RAF1(3), SYK(8), TBXAS1(5) 17698435 105 86 103 22 15 18 33 20 19 0 0.0219 1.000 1.000 134 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(4) 6989177 25 24 25 8 6 7 6 2 4 0 0.397 1.000 1.000 135 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(5), ST3GAL4(1) 5501975 18 17 18 7 5 2 7 2 2 0 0.694 1.000 1.000 136 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 11 APC(27), CDH1(5), CREBBP(40), MAP2K1(5), MAP3K7(8), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2) 14883936 96 73 93 20 11 15 29 21 19 1 0.138 1.000 1.000 137 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(4), MPST(2) 5208192 19 17 19 7 4 1 11 2 1 0 0.707 1.000 1.000 138 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST7(2), CHSY1(3), DSE(2), UST(3), XYLT1(10), XYLT2(3) 10680334 56 51 56 12 14 5 19 11 7 0 0.0687 1.000 1.000 139 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(7), ELK1(2), EPO(2), EPOR(2), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(8), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 15986399 68 61 68 13 13 18 24 4 9 0 0.0109 1.000 1.000 140 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), BRAF(10), CREB1(1), CREB3(1), CREB5(8), RAF1(3), SNX13(2) 7952573 26 20 26 9 2 4 8 6 6 0 0.697 1.000 1.000 141 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(12), GNB1(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7) 7309401 40 35 40 10 14 9 9 4 4 0 0.184 1.000 1.000 142 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1) 5573878 15 15 15 7 2 2 6 4 1 0 0.881 1.000 1.000 143 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), IMPA2(4), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3) 8868988 40 38 40 10 9 11 10 3 7 0 0.0806 1.000 1.000 144 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(7), CCNA2(4), CCND1(4), CCNE1(5), CCNE2(4), CDK4(5), CDKN1B(3), E2F2(3), E2F4(2), PRB1(8) 6397211 45 43 45 14 1 12 13 12 7 0 0.572 1.000 1.000 145 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 5 CREBBP(40), ESR1(6), PELP1(2) 6952436 48 40 47 15 5 7 14 10 11 1 0.419 1.000 1.000 146 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(4) 6469482 24 24 24 9 4 3 6 8 3 0 0.624 1.000 1.000 147 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(12), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3R1(10), RELA(2), SYT1(8) 11981750 62 50 62 13 13 12 14 12 11 0 0.111 1.000 1.000 148 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C8B(9), C9(15), MASP1(9) 14372980 95 77 93 24 15 28 29 15 8 0 0.0540 1.000 1.000 149 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(2), CAMKK2(6), CREB1(1), SYT1(8) 8786689 37 37 37 10 5 7 13 8 4 0 0.366 1.000 1.000 150 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 17 AKT1(2), BAD(2), BCL2L1(2), CASP9(1), CDC42(4), CHUK(6), ELK1(2), H2AFX(1), MAP2K1(5), NFKB1(5), PIK3R1(10), RAF1(3), RALBP1(5), RALGDS(9), RELA(2) 11885461 59 50 59 14 13 11 18 4 13 0 0.146 1.000 1.000 151 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA3(2), ANXA4(2), ANXA6(7), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(4), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 15681651 80 68 79 20 18 13 17 13 18 1 0.0720 1.000 1.000 152 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(5), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(4) 5738999 15 15 15 8 1 3 5 5 1 0 0.913 1.000 1.000 153 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(9), EGFR(21), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(24), RARA(4), RXRA(5), THRA(7), THRB(1) 13131412 84 69 84 22 13 14 24 18 14 1 0.139 1.000 1.000 154 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(1), PTK2B(4), SHC1(3), SOS1(9) 6371114 17 16 17 7 7 2 4 3 1 0 0.710 1.000 1.000 155 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 12 AKT1(2), BAD(2), IGF1R(13), IRS1(4), MAP2K1(5), PIK3R1(10), RAF1(3), SHC1(3), SOS1(9), YWHAH(2) 11923445 53 45 53 13 10 12 16 8 7 0 0.142 1.000 1.000 156 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 11404505 49 45 49 13 10 13 11 8 7 0 0.143 1.000 1.000 157 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 19 CSNK2A1(7), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), THPO(1) 19237986 90 75 90 19 14 22 27 10 17 0 0.0217 1.000 1.000 158 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(5), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(1), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 11454795 52 49 52 14 10 10 15 5 12 0 0.0625 1.000 1.000 159 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(6), ACTN2(11), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(17), ITGB3(8), PTK2(10), PXN(3), SPTAN1(24), TLN1(24) 21398474 118 94 117 23 20 19 44 20 15 0 0.00802 1.000 1.000 160 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(8), FYN(5), LRP8(4), RELN(53), VLDLR(5) 10640095 79 65 79 23 14 16 19 16 14 0 0.233 1.000 1.000 161 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(5), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(4) 8140743 38 34 38 11 5 7 9 12 5 0 0.513 1.000 1.000 162 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F2(3), F2R(4), F3(2), F5(20), F7(3), FGA(10), FGB(4), FGG(6), PROC(2), PROS1(9), SERPINC1(4), TFPI(2) 12450168 73 58 73 19 6 23 21 13 10 0 0.158 1.000 1.000 163 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(1), FARSB(7), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7), YARS2(4) 6612485 35 32 35 10 2 11 12 5 5 0 0.260 1.000 1.000 164 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4) 7051136 31 30 31 10 7 9 5 4 6 0 0.355 1.000 1.000 165 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6) 10251772 47 40 47 11 3 9 18 6 11 0 0.193 1.000 1.000 166 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 20 ACTA1(4), ADCY1(22), CAP1(6), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(12), GNB1(3), MYT1(12), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10) 14810434 95 75 94 22 28 19 24 14 10 0 0.0209 1.000 1.000 167 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(12), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP7(3), CASP9(1), GZMB(2), PRF1(4), SCAP(9), SREBF1(5), SREBF2(5) 12953721 50 45 50 12 10 11 10 10 9 0 0.146 1.000 1.000 168 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(5), APC(27), AXIN1(11), BTRC(1), CTNNB1(6), DLL1(5), DVL1(7), FZD1(6), GSK3B(3), WNT1(2) 13236379 73 53 72 19 13 18 16 13 12 1 0.154 1.000 1.000 169 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), CDKN2C(1), RB1(18), RBL1(11), TFDP1(3) 11744055 66 60 66 18 4 14 14 11 23 0 0.283 1.000 1.000 170 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL12A(1), IL12B(4), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4) 7559330 36 34 36 12 7 9 10 6 4 0 0.460 1.000 1.000 171 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(11), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(9), REG1A(13), SOAT1(5) 10403694 55 51 55 15 10 10 17 9 9 0 0.246 1.000 1.000 172 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(6), MBTPS1(10), MBTPS2(4), SCAP(9), SREBF1(5), SREBF2(5) 9048536 42 40 41 13 6 8 13 10 5 0 0.439 1.000 1.000 173 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(1), CREBBP(40), FYN(5), IL7(1), IL7R(6), JAK1(11), JAK3(6), LCK(5), NMI(6), PIK3R1(10), PTK2B(4), STAT5A(3), STAT5B(5) 15834955 103 78 102 27 10 22 24 22 24 1 0.0533 1.000 1.000 174 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(8), FOS(6), IL3(1), IL3RA(6), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 13118426 57 50 57 15 9 17 17 8 6 0 0.0953 1.000 1.000 175 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(7), ELK1(2), FOS(6), IL2(2), IL2RA(2), IL2RB(3), JAK1(11), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 17382445 85 72 85 21 11 18 28 11 17 0 0.0443 1.000 1.000 176 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(5), JAK1(11), JAK2(5), JAK3(6), PIAS3(4), PTPRU(9), REG1A(13), STAT3(6) 11553078 62 58 62 17 11 11 20 12 8 0 0.171 1.000 1.000 177 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(6), CREBBP(40), FADD(4), HDAC3(3), IKBKB(12), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 13310411 82 72 81 22 12 15 24 16 14 1 0.159 1.000 1.000 178 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(8), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(13), HIF1A(3), KDR(13), NOS3(4), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PXN(3), SHC1(3) 23822343 132 107 132 29 26 33 33 20 20 0 0.0176 1.000 1.000 179 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 22 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(5), HDAC5(3), MEF2A(3), MEF2B(5), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(4), SYT1(8), YWHAH(2) 14716358 56 50 55 14 5 15 19 14 3 0 0.112 1.000 1.000 180 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(2), KLK2(2), NTRK1(3), PIK3R1(10), PLCG1(8), PRKCA(7), SHC1(3), SOS1(9) 9840505 44 40 44 12 7 10 14 7 6 0 0.350 1.000 1.000 181 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 22 ADCY1(22), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(12), MAPK14(2), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RPS6KA1(10), RPS6KA5(5), SOS1(9) 19336048 107 88 106 25 22 25 29 14 17 0 0.0396 1.000 1.000 182 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 18 AKT1(2), CCND1(4), CCNE1(5), CDK4(5), CDK6(2), CDKN1B(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3R1(10), RAF1(3), RB1(18), RELA(2), TFDP1(3) 12559647 66 62 66 18 4 12 14 8 28 0 0.290 1.000 1.000 183 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(2), EGF(9), EGFR(21), MET(4), PDGFRA(14), PRKCA(7), SH3GLB1(2), SH3GLB2(3), SH3KBP1(8) 14746309 73 67 73 21 9 16 23 13 11 1 0.208 1.000 1.000 184 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 185 ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(2), BCAR1(3), BCL2(1), BIRC2(2), BIRC3(2), BRAF(10), CAPN2(6), CAV1(1), CCND1(4), CCND2(2), CDC42(4), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(9), EGFR(21), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(23), FLNB(10), FLNC(15), FLT1(17), FN1(19), FYN(5), GSK3B(3), HGF(13), IBSP(3), IGF1(1), IGF1R(13), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), JUN(1), KDR(13), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), MAP2K1(5), MAPK10(4), MAPK8(4), MAPK9(5), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(53), ROCK1(19), ROCK2(10), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TLN1(24), TLN2(13), TNC(12), TNN(23), TNR(19), TNXB(23), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2) 277078767 1494 416 1481 478 236 322 474 230 226 6 0.0486 1.000 1.000 185 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY7(5), ADCY8(28), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ATP2A1(8), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), ATP2B4(6), AVPR1A(9), AVPR1B(7), BDKRB1(3), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(6), CD38(5), CHRM2(5), CHRM3(9), CHRM5(3), CHRNA7(2), CYSLTR1(2), CYSLTR2(5), DRD1(2), EDNRA(2), EDNRB(7), EGFR(21), ERBB2(11), ERBB3(14), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(12), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), LHCGR(9), LTB4R2(3), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(14), PDGFRB(8), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(7), PTGFR(2), PTK2B(4), RYR1(34), RYR2(79), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(17), SPHK2(5), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), TNNC2(1), TRHR(7), TRPC1(10) 204129430 1231 395 1224 426 259 262 355 203 151 1 0.00576 1.000 1.000 186 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 240 ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(2), ARRB2(3), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(5), CACNB2(7), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(4), CACNG6(5), CACNG7(4), CACNG8(8), CASP3(2), CD14(1), CDC25B(4), CDC42(4), CHUK(6), CRK(2), CRKL(3), DAXX(5), DDIT3(1), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(4), EGF(9), EGFR(21), ELK1(2), ELK4(4), FAS(5), FASLG(1), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FLNA(23), FLNB(10), FLNC(15), FOS(6), GADD45A(1), GADD45G(1), GNA12(2), GNG12(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAPT(9), MAX(1), MKNK1(1), MKNK2(3), MOS(7), MYC(6), NF1(16), NFATC2(15), NFATC4(4), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(14), PDGFRB(8), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(5), PTPRR(5), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(1), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(1), TAOK1(6), TAOK2(16), TAOK3(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF1A(1), TRAF2(2), TRAF6(3), ZAK(5) 212444297 1105 389 1094 362 218 235 323 165 162 2 0.0172 1.000 1.000 187 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(7), ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(4), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(6), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CNR1(4), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(5), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHB(2), FSHR(12), GABBR1(3), GABBR2(6), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GABRB1(8), GABRB2(8), GABRB3(15), GABRD(2), GABRE(8), GABRG1(10), GABRG2(8), GABRG3(8), GABRP(6), GABRQ(10), GABRR1(4), GABRR2(4), GALR1(4), GALR2(4), GALR3(2), GH1(4), GH2(7), GHR(8), GHRHR(4), GHSR(3), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(3), GLRA2(5), GLRA3(4), GLRB(4), GNRHR(3), GPR156(5), GPR35(2), GPR50(6), GPR63(6), GPR83(1), GRIA1(17), GRIA2(16), GRIA3(8), GRIA4(12), GRID1(20), GRID2(21), GRIK1(8), GRIK2(15), GRIK3(8), GRIK4(6), GRIK5(9), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM6(4), GRM7(19), GRM8(23), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LEP(1), LEPR(20), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(3), MAS1(2), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), MCHR1(3), MCHR2(5), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR1(1), NPBWR2(4), NPY1R(6), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), P2RY8(3), PARD3(15), PRL(4), PRLHR(5), PRLR(8), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(7), PTGER4(6), PTGFR(2), PTGIR(2), PTH2R(12), RXFP1(5), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), THRA(7), THRB(1), TRHR(7), TRPV1(7), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(6) 167011664 1236 384 1229 436 225 231 424 201 154 1 0.0184 1.000 1.000 188 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 197 ABI2(3), ACTN1(6), ACTN2(11), ACTN4(6), APC(27), APC2(6), ARAF(2), ARHGEF1(9), ARHGEF12(12), ARHGEF4(5), ARHGEF6(7), ARHGEF7(3), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), BCAR1(3), BDKRB1(3), BDKRB2(3), BRAF(10), CD14(1), CDC42(4), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CRK(2), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(9), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(9), EGFR(21), F2(3), F2R(4), FGD1(12), FGD3(5), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FN1(19), GIT1(5), GNA12(2), GNA13(2), GNG12(1), GSN(5), IQGAP1(11), IQGAP2(6), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(7), MAP2K1(5), MAP2K2(6), MOS(7), MSN(3), MYH10(23), MYH14(7), MYH9(24), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), NCKAP1(8), NCKAP1L(8), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(14), PDGFRB(8), PFN1(1), PFN4(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), RDX(1), ROCK1(19), ROCK2(10), RRAS(2), RRAS2(1), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(7), SSH2(7), SSH3(5), TIAM1(15), TIAM2(13), TMSB4Y(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), WAS(2), WASF1(3), WASF2(5), WASL(2) 205275484 1008 369 996 345 188 206 292 164 156 2 0.303 1.000 1.000 189 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(5), ACTG1(3), CHAD(5), COL11A1(65), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(9), DSG2(3), DSG3(2), DSG4(5), FN1(19), GJA1(2), GJA10(7), GJA3(2), GJA4(1), GJA5(6), GJA8(8), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(3), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(11), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(4), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(5), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(4), KRT35(4), KRT36(6), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(3), KRT72(4), KRT73(4), KRT74(7), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(4), KRT8(1), KRT82(7), KRT83(6), KRT84(1), KRT85(5), KRT86(4), KRT9(3), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), LMNA(1), LMNB1(1), LMNB2(8), NES(13), RELN(53), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VIM(4), VTN(2), VWF(19) 189768350 1052 361 1046 364 175 214 355 150 153 5 0.393 1.000 1.000 190 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 120 ABL1(8), ABLIM1(8), ABLIM2(5), ABLIM3(5), ARHGEF12(12), CDC42(4), CDK5(3), CFL1(2), CXCL12(6), CXCR4(2), DCC(31), DPYSL2(5), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA3(20), EPHA4(11), EPHA5(25), EPHA6(18), EPHA7(24), EPHA8(5), EPHB1(16), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(6), FYN(5), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), ITGB1(17), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(7), LRRC4C(29), MET(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLXNA1(24), PLXNA2(17), PLXNA3(15), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTK2(10), RAC2(2), RAC3(3), RGS3(10), RHOD(1), ROBO1(13), ROBO2(16), ROBO3(6), ROCK1(19), ROCK2(10), SEMA3A(14), SEMA3C(8), SEMA3D(5), SEMA3E(12), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(4), SEMA4C(3), SEMA4D(8), SEMA4F(5), SEMA4G(8), SEMA5B(13), SEMA6A(3), SEMA6B(6), SEMA6C(1), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(25), SLIT3(9), SRGAP1(11), SRGAP2(2), SRGAP3(7), UNC5A(5), UNC5B(8), UNC5C(20), UNC5D(22) 143666998 891 357 884 280 138 184 279 153 135 2 0.0195 1.000 1.000 191 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(9), CD36(2), CD44(3), CD47(1), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DAG1(5), FN1(19), FNDC1(13), FNDC3A(11), FNDC4(3), FNDC5(1), GP5(4), GP6(3), GP9(2), HMMR(2), HSPG2(23), IBSP(3), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), RELN(53), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VTN(2), VWF(19) 169148130 936 348 930 319 151 204 296 141 140 4 0.380 1.000 1.000 192 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(7), ARRB1(2), ARRB2(3), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(16), CACNB1(5), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), ITPR1(16), ITPR2(26), ITPR3(10), KCNB1(3), KCNJ3(11), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(8), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(17), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 142455442 863 346 858 302 180 197 234 139 111 2 0.0237 1.000 1.000 193 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(5), ASH1L(20), CASK(4), CDC42(4), CDK4(5), CGN(5), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTTN(12), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(24), EXOC3(3), EXOC4(15), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(14), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(7), MYH1(22), MYH10(23), MYH11(11), MYH13(28), MYH14(7), MYH15(14), MYH2(28), MYH3(14), MYH4(19), MYH6(20), MYH7(16), MYH7B(10), MYH8(26), MYH9(24), MYL7(2), MYL9(4), MYLPF(2), NRAS(1), OCLN(1), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP2R3A(14), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), RAB13(2), RRAS(2), RRAS2(1), SPTAN1(24), SYMPK(7), TJAP1(4), TJP1(12), TJP2(5), TJP3(6), VAPA(2), YES1(3), ZAK(5) 146368196 838 337 826 258 144 186 258 132 116 2 0.0138 1.000 1.000 194 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(3), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADM(1), ARRB1(2), ARRB2(3), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(6), CACNB3(3), CALCA(3), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CREB3(1), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(9), GJA1(2), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), GSTO1(2), GUCA2A(1), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(2), PDE4B(9), PDE4D(10), PKIG(1), PLCB3(8), PLCD1(4), PLCG1(8), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(23), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 131546288 757 332 754 265 141 186 212 120 96 2 0.0731 1.000 1.000 195 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(5), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(2), CCL3(1), CCL8(3), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(5), CNTFR(1), CRLF2(4), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(8), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(1), CXCL14(1), CXCL16(3), CXCL2(1), CXCL3(1), CXCL5(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(4), EDA2R(1), EDAR(2), EGF(9), EGFR(21), EPO(2), EPOR(2), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(13), GDF5(4), GH1(4), GH2(7), GHR(8), HGF(13), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(6), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), INHBA(4), INHBB(4), INHBC(3), INHBE(1), KDR(13), KIT(11), KITLG(1), LEP(1), LEPR(20), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(2), OSMR(5), PDGFB(1), PDGFC(3), PDGFRA(14), PDGFRB(8), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(4), PRLR(8), RELT(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(2), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(11), TSLP(1), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3) 133839974 691 309 687 226 105 135 226 124 100 1 0.169 1.000 1.000 196 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADK(2), ADSL(5), ADSS(4), ADSSL1(6), AK1(1), AK2(1), AK5(12), AK7(2), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(1), GART(4), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE11A(3), PDE1A(6), PDE1C(14), PDE2A(4), PDE3B(4), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PDE9A(3), PFAS(13), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(6) 122900958 616 300 613 199 108 132 185 101 90 0 0.127 1.000 1.000 197 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 139 APC(27), APC2(6), AXIN1(11), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(4), CCND2(2), CER1(1), CHD8(16), CREBBP(40), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTBP1(2), CTBP2(8), CTNNB1(6), CUL1(11), CXXC4(4), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(7), DVL2(1), DVL3(9), FBXW11(3), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(6), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(5), MMP7(1), MYC(6), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKD1(8), NKD2(3), NLK(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PORCN(2), PPARD(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAC2(2), RAC3(3), RBX1(3), ROCK1(19), ROCK2(10), SENP2(3), SFRP1(4), SFRP4(12), SFRP5(1), SIAH1(5), SKP1(1), SMAD2(4), SMAD3(4), SOX17(3), TBL1X(6), TBL1XR1(5), TBL1Y(3), TCF7(3), TCF7L1(2), TCF7L2(1), VANGL1(2), VANGL2(5), WIF1(1), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 117179899 663 298 657 203 111 142 198 109 101 2 0.0152 1.000 1.000 198 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(3), ACTN2(11), ACTN4(6), DES(3), DMD(53), MYBPC1(13), MYBPC2(8), MYBPC3(5), MYH3(14), MYH6(20), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(42), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(4), TNNT3(3), TPM1(2), TPM2(2), TPM4(1), TTN(434), VIM(4) 103717356 706 297 700 198 93 180 252 105 70 6 0.109 1.000 1.000 199 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(7), CADM1(4), CADM3(5), CD2(1), CD22(3), CD226(5), CD274(1), CD276(1), CD28(3), CD34(6), CD4(1), CD40(7), CD40LG(5), CD58(2), CD6(1), CD80(5), CD86(2), CD8A(2), CD8B(2), CD99(1), CDH1(5), CDH15(3), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(11), CNTN2(8), CNTNAP1(9), CNTNAP2(27), CTLA4(2), ESAM(4), F11R(3), GLG1(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(13), ITGA6(4), ITGA9(3), ITGAL(7), ITGAM(8), ITGAV(6), ITGB1(17), ITGB2(4), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(4), NCAM2(13), NEGR1(7), NEO1(4), NFASC(6), NLGN1(19), NLGN2(6), NLGN3(3), NRCAM(14), NRXN1(31), NRXN2(10), NRXN3(24), OCLN(1), PDCD1(2), PTPRC(19), PTPRF(17), PTPRM(25), PVR(5), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SELE(7), SELL(2), SELP(15), SELPLG(1), SIGLEC1(13), SPN(3), VCAM1(10), VCAN(32) 109550739 643 288 636 237 101 135 185 116 106 0 0.525 1.000 1.000 200 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(9), EGFR(21), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(12), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HTR2A(5), HTR2B(2), HTR2C(3), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(1), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), TJP1(12), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2) 99622820 594 286 588 175 111 134 173 109 66 1 0.000849 1.000 1.000 201 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(4), CCND2(2), CISH(1), CNTFR(1), CREBBP(40), CRLF2(4), CSF2RA(1), CSF2RB(8), CSF3R(3), EPO(2), EPOR(2), GH1(4), GH2(7), GHR(8), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL13RA2(4), IL19(4), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), IRF9(4), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(5), PIAS1(1), PIAS2(3), PIAS3(4), PIAS4(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIM1(3), PRL(4), PRLR(8), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(7), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(7), STAT2(6), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(11), TSLP(1), TYK2(8) 105156382 564 285 556 170 73 122 174 111 83 1 0.0458 1.000 1.000 202 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(4), CGA(1), EGFR(21), ELK1(2), FSHB(2), GNA11(4), GNAS(12), GNRHR(3), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(5), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLD1(17), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11) 95661740 545 285 539 177 108 126 153 94 64 0 0.0178 1.000 1.000 203 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(8), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(6), GPR6(5), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LHCGR(9), LTB4R(3), MAS1(2), MC1R(2), MC3R(4), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(8), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(2), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), RGR(4), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SUCNR1(1), TBXA2R(1), TRHR(7) 92000845 572 283 569 226 116 120 191 90 55 0 0.0823 1.000 1.000 204 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(16), ACACB(20), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(4), FOXO1(3), G6PC(2), G6PC2(7), GCK(4), GSK3B(3), GYS1(7), GYS2(7), IKBKB(12), INPP5D(10), INSR(3), IRS1(4), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK10(4), MAPK8(4), MAPK9(5), MKNK1(1), MKNK2(3), NRAS(1), PCK1(1), PCK2(4), PDE3A(18), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(13), PPP1R3B(3), PPP1R3C(2), PPP1R3D(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAG3(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(17), PYGB(5), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(5), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(5), TSC2(8) 119336369 577 282 572 190 117 116 161 96 87 0 0.118 1.000 1.000 205 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), AKAP1(8), AKAP10(5), AKAP11(8), AKAP12(13), AKAP2(1), AKAP3(8), AKAP4(11), AKAP5(3), AKAP6(27), AKAP7(5), AKAP8(4), AKAP9(30), ARHGEF1(9), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(2), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB5(2), GNG10(1), GNG12(1), GNG13(2), IL18BP(1), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PLCB3(8), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RRAS(2), SLC9A1(4), USP5(5) 88186925 530 279 526 140 107 125 138 87 73 0 0.000121 1.000 1.000 206 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADK(2), ADSL(5), ADSS(4), AK1(1), AK2(1), AK5(12), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(4), GDA(7), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(13), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(1), RRM2(1) 97524512 517 274 514 158 88 111 167 76 75 0 0.0370 1.000 1.000 207 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(6), ACTN2(11), ACTN4(6), ARHGAP5(10), BCAR1(3), CD99(1), CDC42(4), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), CXCL12(6), CXCR4(2), CYBB(3), ESAM(4), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), ITK(3), JAM2(2), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), MYLPF(2), NCF1(2), NCF2(6), NCF4(3), NOX1(6), NOX3(8), OCLN(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAC2(2), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOH(1), ROCK1(19), ROCK2(10), SIPA1(3), THY1(2), TXK(5), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCAM1(10), VCL(6) 92316933 506 264 499 166 87 94 139 93 92 1 0.259 1.000 1.000 208 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 69 ACP1(1), ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(3), CDC42(4), CDH1(5), CREBBP(40), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), EGFR(21), ERBB2(11), FARP2(3), FER(6), FGFR1(4), FYN(5), IGF1R(13), INSR(3), IQGAP1(11), LEF1(6), LMO7(8), MAP3K7(8), MET(4), MLLT4(13), NLK(1), PARD3(15), PTPN1(3), PTPN6(3), PTPRB(24), PTPRF(17), PTPRJ(7), PTPRM(25), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(3), RAC2(2), RAC3(3), SMAD2(4), SMAD3(4), SNAI2(1), SORBS1(7), SSX2IP(6), TCF7(3), TCF7L1(2), TCF7L2(1), TGFBR1(2), TJP1(12), VCL(6), WAS(2), WASF1(3), WASF2(5), WASF3(7), WASL(2), YES1(3) 84358819 477 263 471 148 75 98 137 90 75 2 0.201 1.000 1.000 209 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(1), CREB3L1(4), CREB3L2(3), CREB3L3(10), CREB3L4(2), CREBBP(40), CTNNB1(6), DCT(4), DVL1(7), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GSK3B(3), KIT(11), KITLG(1), KRAS(1), LEF1(6), MAP2K1(5), MAP2K2(6), MC1R(2), MITF(7), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), POMC(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(3), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 78415402 480 262 475 146 105 90 135 85 63 2 0.00261 1.000 1.000 210 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(22), ADCY8(28), ARAF(2), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(40), GRIA1(17), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP1CA(1), PPP1R12A(5), PPP1R1A(2), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8) 70906136 488 257 483 163 83 111 136 97 60 1 0.0591 1.000 1.000 211 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(8), ABL2(11), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), BTC(3), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(3), CRK(2), CRKL(3), EGF(9), EGFR(21), EIF4EBP1(1), ELK1(2), ERBB2(11), ERBB3(14), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK9(5), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(4), NRG2(6), NRG3(17), NRG4(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), RAF1(3), RPS6KB1(5), RPS6KB2(2), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), STAT5A(3), STAT5B(5) 75815462 446 254 440 139 61 93 147 86 58 1 0.211 1.000 1.000 212 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(10), INPP5E(1), INPPL1(9), ITPK1(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), OCRL(4), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PRKCA(7), PRKCG(14), PTPMT1(2), SYNJ1(10), SYNJ2(9) 92234964 478 251 471 143 76 101 129 92 80 0 0.0196 1.000 1.000 213 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(2), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(2), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GNAZ(7), GRIA1(17), GRIA2(16), GRIA3(8), GRID2(21), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), IGF1(1), IGF1R(13), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), RAF1(3), RYR1(34) 82750691 489 250 487 153 90 101 146 92 60 0 0.0530 1.000 1.000 214 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(5), ACVR1B(5), ACVRL1(4), AKT1(2), AURKB(3), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(8), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MAP3K10(6), MOS(7), NEK1(9), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9), PLK3(6), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(8), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KB1(5), STK11(7), TGFBR1(2), VRK1(1) 84052961 463 248 456 137 83 86 142 75 77 0 0.0337 1.000 1.000 215 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), AMY2B(9), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(7), GAA(3), GANC(6), GBA(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), IFIH1(6), MGAM(37), MOV10L1(6), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SI(61), SKIV2L2(4), SMARCA2(13), SMARCA5(2), TREH(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UXS1(2) 94008768 473 247 471 145 56 95 154 95 71 2 0.309 1.000 1.000 216 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(13), ABCA12(19), ABCA13(39), ABCA2(17), ABCA3(10), ABCA4(15), ABCA5(6), ABCA6(11), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(20), ABCB11(9), ABCB4(13), ABCB5(12), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(9), ABCC12(11), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(9), ABCG8(13), CFTR(14), TAP1(6), TAP2(6) 89789433 441 247 439 143 65 93 133 70 80 0 0.0709 1.000 1.000 217 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 119 ARAF(2), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FCGR3B(5), FYN(5), GZMB(2), HLA-C(5), HLA-E(1), HLA-G(2), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), ITGAL(7), ITGB2(4), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KLRC1(1), KLRC2(1), KLRC3(4), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MICB(3), NCR1(6), NCR2(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NRAS(1), PAK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRF1(4), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC2(2), RAC3(3), RAF1(3), SH2D1B(2), SH3BP2(4), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 82247418 433 244 427 140 86 83 119 70 75 0 0.122 1.000 1.000 218 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(8), ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(25), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(4), CDC26(1), CDC27(8), CDC6(2), CDC7(1), CDK4(5), CDK6(2), CDKN1B(3), CDKN2C(1), CHEK1(1), CHEK2(5), CREBBP(40), CUL1(11), DBF4(3), E2F2(3), E2F3(3), ESPL1(10), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(18), RBL1(11), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMC1A(3), SMC1B(7), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 97716577 411 239 409 133 40 100 103 87 80 1 0.522 1.000 1.000 219 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(5), CD8A(2), CD8B(2), CDC42(4), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(5), GRAP2(2), ICOS(1), IFNG(2), IKBKB(12), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCQ(8), PTPN6(3), PTPRC(19), RASGRP1(8), SOS1(9), SOS2(11), TEC(2), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 74997338 390 238 388 126 66 75 112 68 69 0 0.338 1.000 1.000 220 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(4), CAPN11(2), CAPN2(6), CAPN3(5), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(4), CAPNS1(2), CAV1(1), CDC42(4), CRK(2), CSK(1), DOCK1(15), FYN(5), GIT2(3), ILK(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(8), MAPK6(3), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(10), SDCCAG8(7), SEPP1(3), SHC1(3), SHC3(6), SORBS1(7), SOS1(9), TLN1(24), TNS1(8), VASP(1), VAV2(4), VAV3(4), VCL(6), ZYX(2) 99922567 461 235 456 152 78 100 137 72 74 0 0.126 1.000 1.000 221 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(2), AKT2(4), AKT3(6), CCL3(1), CD14(1), CD40(7), CD80(5), CD86(2), CHUK(6), CXCL10(2), CXCL9(3), FADD(4), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IKBKB(12), IKBKE(5), IL12A(1), IL12B(4), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(3), IRF5(3), IRF7(3), JUN(1), LBP(8), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), RELA(2), RIPK1(2), SPP1(2), STAT1(7), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(3), TLR3(2), TLR4(16), TLR5(4), TLR6(4), TLR7(8), TLR8(7), TLR9(7), TOLLIP(2), TRAF3(6), TRAF6(3) 64937456 347 221 344 116 56 75 105 55 56 0 0.204 1.000 1.000 222 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(3), CHPF(7), CHST1(4), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST2(5), CHST4(4), CHST6(8), CHST7(2), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GANAB(3), GCNT1(1), GCNT3(1), GCNT4(3), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST6GAL1(3), ST6GALNAC1(4), STT3B(2), UST(3), WBSCR17(9), XYLT1(10), XYLT2(3) 84055408 358 217 358 141 74 72 115 50 46 1 0.794 1.000 1.000 223 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 83 ACVR1(5), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BMPR1B(4), BMPR2(6), CHRD(12), CREBBP(40), CUL1(11), DCN(4), E2F4(2), E2F5(6), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(4), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MYC(6), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), RBL1(11), RBL2(6), RBX1(3), ROCK1(19), ROCK2(10), RPS6KB1(5), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(3), SMURF2(6), SP1(3), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), ZFYVE16(10), ZFYVE9(8) 69028546 365 217 362 96 36 81 108 71 68 1 0.0108 1.000 1.000 224 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 73 ABL1(8), ACTN1(6), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(3), BCAR1(3), BRAF(10), CAV1(1), CDC42(4), CRK(2), CSE1L(2), DOCK1(15), EPHB2(3), FYN(5), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(4), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PKLR(3), PLCG1(8), PLCG2(9), PTK2(10), RAF1(3), RHO(3), ROCK1(19), ROCK2(10), SHC1(3), SOS1(9), SOS2(11), TLN1(24), TLN2(13), VASP(1), WAS(2), ZYX(2) 88152167 374 216 372 136 62 66 119 74 53 0 0.724 1.000 1.000 225 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(7), BDKRB1(3), BDKRB2(3), C1QA(3), C1QC(1), C1R(4), C1S(6), C2(2), C3(16), C3AR1(5), C4BPA(5), C4BPB(2), C5(11), C5AR1(2), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(3), CD55(1), CD59(1), CFB(8), CFH(19), CFI(5), CPB2(4), CR1(10), CR2(9), F10(4), F11(2), F12(2), F13A1(8), F13B(13), F2(3), F2R(4), F3(2), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), KNG1(5), MASP1(9), MASP2(5), MBL2(2), PLAT(3), PLAU(3), PLG(13), PROC(2), PROS1(9), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(8), SERPING1(5), TFPI(2), THBD(2), VWF(19) 67386746 389 213 386 136 49 99 113 69 58 1 0.538 1.000 1.000 226 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(5), BAD(2), BCL2(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(4), CREBBP(40), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(9), GSK3A(2), GSK3B(3), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(5), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB2(5), NFKBIB(2), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(19), RELA(2), RPL13A(2), SFN(7), SLA(3), SP1(3), SP3(3), TGFB1(2), TRAF2(2), TRPV6(7), VAV1(8), VAV2(4), VAV3(4), XPO5(4) 65282583 331 208 330 116 46 64 99 66 55 1 0.484 1.000 1.000 227 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(8), ATM(16), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND2(2), CCNE1(5), CCNE2(4), CDAN1(7), CDC14A(3), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CHEK1(1), CHEK2(5), DTX4(5), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), ESPL1(10), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), HDAC8(2), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(4), RB1(18), RBL1(11), SKP2(4), TBC1D8(4), TFDP1(3), TGFB1(2), WEE1(1) 77872752 308 202 307 105 35 72 78 58 65 0 0.663 1.000 1.000 228 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(5), ELK1(2), FOS(6), IKBKB(12), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAP4K5(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(8), MAPK6(3), MAPK7(6), MAPK8(4), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MKNK2(3), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(5), RPS6KB2(2), SHC1(3), SP1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 70775698 330 201 325 107 58 68 107 52 45 0 0.353 1.000 1.000 229 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2L1(2), CDC42(4), CDKN1B(3), CREB1(1), CREB3(1), CREB5(8), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PPP1R13B(2), PREX1(15), PTK2(10), PTPN1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SLC2A4(4), SOS1(9), SOS2(11), TSC1(5), TSC2(8), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 56091953 297 198 295 90 43 65 86 53 50 0 0.110 1.000 1.000 230 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(5), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(9), FCGR2B(1), FOS(6), GSK3B(3), IKBKB(12), INPP5D(10), JUN(1), KRAS(1), LILRB3(5), LYN(8), MALT1(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(2), RAC3(3), RASGRP3(8), SYK(8), VAV1(8), VAV2(4), VAV3(4) 54401076 294 194 292 94 59 60 76 50 48 1 0.153 1.000 1.000 231 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(20), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(2), CAMKK2(6), CD36(2), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(7), IKBKB(12), IRS1(4), IRS2(6), IRS4(16), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), MAPK10(4), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NPY(5), PCK1(1), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(5), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), STK11(7), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8) 63166369 321 194 321 102 55 62 96 55 52 1 0.112 1.000 1.000 232 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CAPN1(3), CAPN2(6), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(8), FADD(4), FAS(5), FASLG(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(6), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(2) 60402234 270 188 267 86 48 61 64 49 48 0 0.225 1.000 1.000 233 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(5), GAB2(4), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(10), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MS4A2(5), NRAS(1), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC2(2), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8), VAV2(4), VAV3(4) 52007868 282 185 280 95 50 49 87 47 48 1 0.471 1.000 1.000 234 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(11), EZH1(5), EZH2(5), FBXO11(7), HCFC1(8), HSF4(1), JMJD4(2), JMJD6(2), KDM6A(17), MEN1(3), OGT(4), PAXIP1(5), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(37), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(2), SATB1(6), SETD1A(11), SETD2(12), SETD7(4), SETD8(1), SETDB1(10), SETDB2(2), SETMAR(2), SMYD3(2), STK38(3), SUV39H1(5), SUV39H2(2), SUV420H1(8), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6) 86174587 281 182 276 79 43 52 85 50 51 0 0.142 1.000 1.000 235 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(9), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(4), MIOX(4), OCRL(4), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PTPMT1(2), SYNJ1(10), SYNJ2(9) 54225122 272 182 267 92 54 51 80 48 39 0 0.189 1.000 1.000 236 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(2), AKT2(4), AKT3(6), BAD(2), CASP9(1), CDC42(4), KDR(13), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(4), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NOS3(4), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCA(7), PRKCG(14), PTGS2(4), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), SHC2(5), SPHK2(5) 52040639 273 181 271 96 59 55 74 44 41 0 0.334 1.000 1.000 237 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(3), GRPR(1), LHCGR(9), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), NMBR(3), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), TACR1(3), TACR2(4), TACR3(6), TRHR(7), TSHR(4) 39301078 274 180 273 96 52 64 86 38 34 0 0.0308 1.000 1.000 238 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(6), CPSF2(5), CPSF3(2), CSTF1(2), CSTF2(2), CSTF2T(2), CSTF3(2), DDIT3(1), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(2), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(3), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(11), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(13), PTBP1(3), PTBP2(4), RBM17(1), RBM5(9), RNGTT(2), RNMT(5), RNPS1(5), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(4), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(5), SRPK1(1), SRPK2(8), SRRM1(4), SUPT5H(4), U2AF1(4), U2AF2(2), XRN2(8) 80511676 293 179 291 103 34 71 83 51 54 0 0.815 1.000 1.000 239 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(10), CPEB1(6), EGFR(21), ERBB2(11), ERBB4(22), ETS1(4), ETS2(7), ETV6(6), ETV7(4), FMN2(41), KRAS(1), MAP2K1(5), NOTCH2(21), NOTCH3(23), NOTCH4(8), PIWIL1(11), PIWIL2(9), PIWIL3(7), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1) 36177175 249 175 245 77 34 48 82 42 43 0 0.596 1.000 1.000 240 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(4), CCKBR(6), CCR2(5), CCR3(6), CELSR1(23), CELSR2(25), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(4), GNRHR(3), GPR116(8), GPR132(4), GPR133(10), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR61(3), GPR84(3), GRM1(30), GRPR(1), HRH4(3), LGR6(10), LPHN2(11), LPHN3(24), LTB4R2(3), NTSR1(3), OR2M4(6), P2RY13(3), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2) 50653530 279 173 278 108 52 63 84 46 34 0 0.322 1.000 1.000 241 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(9), ARHGEF11(4), BTK(8), CDC42(4), CFL1(2), GDI1(4), GDI2(5), INPPL1(9), ITPR1(16), ITPR2(26), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CD(8), PIK3CG(20), PIK3R1(10), PITX2(2), PPP1R13B(2), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(10), SAG(1), WASF1(3), WASL(2) 50927844 253 169 251 101 42 65 65 45 35 1 0.741 1.000 1.000 242 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 CD14(1), CD19(4), CD1A(7), CD1B(3), CD1C(5), CD1D(5), CD2(1), CD22(3), CD33(2), CD34(6), CD36(2), CD37(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD55(1), CD59(1), CD7(2), CD8A(2), CD8B(2), CD9(1), CR1(10), CR2(9), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(3), EPO(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), GYPA(5), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL7(1), IL7R(6), IL9R(11), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(8), KIT(11), KITLG(1), MME(16), MS4A1(3), TFRC(7), THPO(1), TPO(11) 61431156 283 168 280 114 43 57 82 56 45 0 0.909 1.000 1.000 243 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), BCR(2), BLNK(5), BTK(8), CD19(4), CD22(3), CR2(9), CSK(1), DAG1(5), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), INPP5D(10), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), MAP4K1(4), NFATC1(10), NFATC2(15), NR0B2(1), PDK1(3), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(19), RAF1(3), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 54031389 259 168 258 95 45 58 58 57 40 1 0.482 1.000 1.000 244 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), AMY2B(9), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), MGAM(37), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), SI(61), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UXS1(2) 43197822 255 167 253 83 30 48 82 52 41 2 0.494 1.000 1.000 245 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(16), CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG2(4), CDC25A(2), CDK4(5), CDKN1B(3), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(10), CREB3L4(2), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), GADD45A(1), GBA2(9), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MNAT1(1), MYC(6), MYT1(12), NACA(25), PCNA(1), POLA2(2), POLE(11), POLE2(1), PRIM1(3), RB1(18), RBL1(11), RPA1(5), RPA2(1), TFDP1(3), TFDP2(1), TNXB(23), WEE1(1) 57694492 255 166 252 71 29 67 72 38 48 1 0.0758 1.000 1.000 246 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(5), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(4), CHUK(6), CSK(1), CXCL1(3), EGFR(21), F11R(3), GIT1(5), IGSF5(4), IKBKB(12), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(8), PAK1(3), PLCG1(8), PLCG2(9), PTPN11(2), PTPRZ1(16), RELA(2), TCIRG1(8), TJP1(12) 53097613 243 163 242 75 27 54 75 48 39 0 0.303 1.000 1.000 247 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ANGPTL4(3), APOA2(1), APOA5(2), AQP7(3), CD36(2), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(3), CYP4A22(10), CYP7A1(6), CYP8B1(6), DBI(5), EHHADH(5), FABP1(4), FABP2(2), FABP3(1), FABP4(4), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(5), GK2(8), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(7), NR1H3(1), OLR1(1), PCK1(1), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRA(5), RXRB(3), RXRG(7), SCD(1), SCP2(2), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1) 48966333 226 159 225 84 40 51 65 31 38 1 0.536 1.000 1.000 248 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(21), EPHB2(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PI3(2), PIK3CB(7), PITX2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), RAF1(3), RGS20(4), SHC1(3), SOS1(9), SOS2(11), STAT3(6) 43856905 228 159 227 76 33 51 64 57 23 0 0.267 1.000 1.000 249 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UPB1(2), UPP1(3), UPP2(4), UPRT(2) 61520900 242 158 242 92 40 43 67 51 41 0 0.864 1.000 1.000 250 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 ADAM17(5), APH1A(4), CREBBP(40), CTBP1(2), CTBP2(8), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(7), DVL2(1), DVL3(9), HDAC1(1), HDAC2(3), JAG1(7), JAG2(8), LFNG(3), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(24), NCSTN(2), NOTCH2(21), NOTCH3(23), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(8), RBPJL(5), RFNG(3), SNW1(5) 45988128 249 158 247 100 48 53 61 36 50 1 0.817 1.000 1.000 251 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(15), GLI3(12), GSK3B(3), HHIP(7), IHH(2), LRP2(42), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(14), PTCH2(11), RAB23(2), SHH(2), SMO(3), STK36(7), SUFU(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3), ZIC2(6) 46317598 240 158 239 90 52 46 83 34 25 0 0.567 1.000 1.000 252 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(27), AXIN1(11), CCND1(4), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(7), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(6), MAPK10(4), MAPK9(5), MYC(6), PAFAH1B1(1), PLAU(3), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), SFRP4(12), TCF7(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1) 45136374 248 155 244 85 40 53 78 50 26 1 0.274 1.000 1.000 253 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 47 ACOX1(2), APOA2(1), CD36(2), CPT1B(4), CREBBP(40), DUSP1(2), EHHADH(5), FABP1(4), HSD17B4(5), JUN(1), LPL(4), ME1(2), MYC(6), NCOA1(7), NCOR1(21), NCOR2(24), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(9), PIK3R1(10), PPARA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(4), RB1(18), RELA(2), RXRA(5), SP1(3), STAT5A(3), STAT5B(5) 42216979 220 154 213 63 25 54 59 30 51 1 0.0760 1.000 1.000 254 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(2), AKT2(4), AKT3(6), BRD4(9), CAP1(6), CBL(3), CDC42(4), F2RL2(2), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), LNPEP(5), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PIK3R1(10), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(7), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 42074484 217 154 216 63 38 49 58 39 33 0 0.119 1.000 1.000 255 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(12), ATM(16), ATR(25), BAI1(8), BAX(2), BID(3), CASP3(2), CASP9(1), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(2), CHEK1(1), CHEK2(5), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(8), IGF1(1), IGFBP3(1), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(6), RCHY1(2), RFWD2(2), RRM2(1), RRM2B(1), SERPINE1(8), SESN1(3), SESN2(3), SESN3(3), SFN(7), SIAH1(5), STEAP3(4), THBS1(8), TNFRSF10B(1), TSC2(8), ZMAT3(2) 47227163 209 151 209 58 22 53 43 46 45 0 0.117 1.000 1.000 256 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(14), GNAS(12), GNAT3(6), GNB1(3), GNB3(7), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(4), SCNN1B(6), SCNN1G(6), TAS1R1(8), TAS1R2(3), TAS1R3(3), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R14(5), TAS2R16(4), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R40(8), TAS2R41(3), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(6) 43345617 230 150 228 108 50 42 54 47 37 0 0.932 1.000 1.000 257 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(13), KDR(13), NOS3(4), PDE2A(4), PDE3A(18), PDE3B(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKG1(8), PRKG2(2), RYR2(79), SLC7A1(4), SYT1(8) 30730065 205 149 205 74 34 52 58 37 23 1 0.516 1.000 1.000 258 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT2(2), ACMSD(4), AFMID(6), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), NFX1(2), OGDH(11), OGDHL(12), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(4), TPH1(2), TPH2(6), WARS(2), WARS2(8) 45967534 202 147 202 65 29 45 64 32 32 0 0.306 1.000 1.000 259 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(6), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CRADD(1), DAXX(5), FADD(4), GSN(5), LMNA(1), LMNB1(1), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(2), NFKB1(5), NFKBIA(1), NUMA1(18), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(10), RB1(18), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 50295853 224 146 224 73 30 48 62 36 48 0 0.445 1.000 1.000 260 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(4), DGAT1(1), DGAT2(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), GK(5), GK2(8), GLA(3), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 44508420 201 144 200 61 26 44 53 41 37 0 0.113 1.000 1.000 261 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PRKAA1(4), PRKAA2(4), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), STK11(7), TSC1(5), TSC2(8), ULK1(8), ULK2(2), VEGFB(1), VEGFC(6) 38250667 198 144 195 54 34 42 52 32 38 0 0.0897 1.000 1.000 262 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 47 ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(40), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), IGF1(1), LIF(2), MAP2K1(5), MAPK14(2), MAPK8(4), MYH2(28), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKX2-5(1), NPPA(3), PIK3R1(10), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(5), SYT1(8) 35440055 202 141 201 64 35 44 59 31 32 1 0.152 1.000 1.000 263 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB3(1), CREB5(8), CREBBP(40), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), NTRK1(3), OPN1LW(3), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PTPN11(2), RPS6KA3(4), SHC1(3), TH(3) 36969164 187 141 185 50 28 34 51 34 39 1 0.0884 1.000 1.000 264 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(2), BAK1(1), BAX(2), BTK(8), CAD(5), CASP10(3), CASP3(2), CD7(2), CSNK1A1(1), DAXX(5), DEDD(1), DEDD2(5), DIABLO(2), EGFR(21), EPHB2(3), FADD(4), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MET(4), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR0B2(1), PFN1(1), PTPN13(13), RALBP1(5), RIPK1(2), ROCK1(19), SMPD1(2), TNFRSF6B(4), TPX2(5), TRAF2(2), TUFM(2) 53450829 202 141 202 61 30 45 61 28 37 1 0.219 1.000 1.000 265 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(2), ACMSD(4), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(2), WARS(2), WARS2(8) 41837003 188 139 188 65 25 40 62 33 27 1 0.482 1.000 1.000 266 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(12), BAD(2), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(2), BIRC3(2), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CHUK(6), FADD(4), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(12), IRF1(8), IRF2(8), IRF3(3), IRF4(5), IRF5(3), IRF6(6), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), PLEKHG5(6), PRF1(4), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2), TRAF3(6) 42241605 192 138 189 56 37 50 43 23 39 0 0.0706 1.000 1.000 267 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(7), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 44194172 185 138 185 78 29 49 48 30 29 0 0.808 1.000 1.000 268 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C2(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7) 43717129 210 138 210 81 29 43 68 41 28 1 0.783 1.000 1.000 269 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39643784 205 138 202 74 34 48 60 25 37 1 0.446 1.000 1.000 270 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39643784 205 138 202 74 34 48 60 25 37 1 0.446 1.000 1.000 271 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), RRM1(1), RRM2(1), TXNRD1(6), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UNG(2), UPB1(2), UPP1(3) 43605398 187 138 187 60 27 34 59 32 35 0 0.374 1.000 1.000 272 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), FLOT1(2), FLOT2(4), GAB1(5), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(15), PTPRC(19), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SAG(1), SYK(8), TEC(2), VAV1(8) 39121694 194 138 193 70 28 48 46 40 31 1 0.470 1.000 1.000 273 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(21), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK10(4), MAPK14(2), PHKA2(9), PIK3CD(8), PIK3R1(10), PITX2(2), PTX3(4), RAF1(3) 38267398 198 137 196 63 30 45 52 41 30 0 0.213 1.000 1.000 274 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), GRAP2(2), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), NCK1(5), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLCG1(8), PTPRC(19), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), SOS1(9), SOS2(11), VAV1(8), ZAP70(2) 40747494 188 136 188 64 25 36 58 27 42 0 0.586 1.000 1.000 275 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(2), CARM1(5), CYP11B1(7), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7) 38193915 185 135 185 60 34 33 60 36 22 0 0.374 1.000 1.000 276 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MIOX(4), OCRL(4), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9) 32377525 178 134 173 48 33 31 55 31 28 0 0.0607 1.000 1.000 277 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHFR(3), DHX58(2), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), FPGS(2), GGH(3), IFIH1(6), MOV10L1(6), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SKIV2L2(4), SMARCA2(13), SMARCA5(2) 47813003 180 132 180 55 23 36 58 35 28 0 0.365 1.000 1.000 278 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(4), CFL1(2), FLNA(23), FLNC(15), FSCN1(2), FSCN2(1), FSCN3(6), GDI1(4), GDI2(5), LIMK1(5), MYH2(28), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PFN1(1), RHO(3), ROCK1(19), ROCK2(10), VASP(1), WASF1(3), WASL(2) 36437833 191 132 191 75 32 45 53 28 33 0 0.659 1.000 1.000 279 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), OGDH(11), OGDHL(12), PIPOX(2), PLOD1(3), PLOD2(8), PLOD3(4), RDH11(2), RDH12(4), SETD1A(11), SETD7(4), SETDB1(10), SHMT1(1), SHMT2(2), SPCS1(2), SPCS3(1), SUV39H1(5), SUV39H2(2), TMLHE(2) 39947494 175 131 175 63 34 32 49 34 26 0 0.495 1.000 1.000 280 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCR(2), BLNK(5), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PI3(2), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 38028694 175 131 175 58 35 31 47 28 33 1 0.357 1.000 1.000 281 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 23 BRCA1(12), CARM1(5), CCND1(4), CREBBP(40), ERCC3(5), ESR1(6), GRIP1(11), GTF2A1(3), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), NCOR2(24), NR0B1(5), NRIP1(9), PELP1(2), POLR2A(11), TBP(2) 30546205 178 130 177 63 19 33 53 38 34 1 0.611 1.000 1.000 282 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(10), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(1), NDUFA2(1), NDUFA3(3), NDUFA5(3), NDUFA7(2), NDUFA9(2), NDUFB1(1), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(5), PPA1(1), SDHA(7), SDHB(1), SDHC(1), TCIRG1(8), UQCRC1(1), UQCRC2(1), UQCRFS1(4) 42404427 177 130 176 47 18 38 59 33 29 0 0.0872 1.000 1.000 283 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), GK(5), GLA(3), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 36570399 166 126 165 52 21 33 45 31 36 0 0.193 1.000 1.000 284 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(35), B3GALT4(4), CDR1(7), DGKI(11), IL6ST(4), MRPL19(3), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL18A(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(3), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5) 39813299 179 126 179 71 21 39 67 25 27 0 0.909 1.000 1.000 285 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), F10(4), F11(2), F12(2), F2(3), F2R(4), F5(20), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), PROC(2), PROS1(9), SERPINC1(4), SERPING1(5) 33727835 171 125 170 55 16 52 47 31 25 0 0.585 1.000 1.000 286 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(1), CHUK(6), DAXX(5), EGF(9), EGFR(21), ETS1(4), ETS2(7), FOS(6), HOXA7(4), IKBKB(12), JUN(1), MAP2K1(5), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(1), TNFRSF1B(2), TRAF2(2) 36684011 173 125 173 64 29 35 54 28 26 1 0.600 1.000 1.000 287 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(4), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(5), MYEF2(7), NFATC3(6), NR2C2(1), PAPPA(13), SHC1(3), TRAF6(3), ZAK(5) 37764870 173 125 170 45 28 40 58 25 22 0 0.106 1.000 1.000 288 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), CARM1(5), COMT(2), DBH(8), DCT(4), DDC(7), ECH1(2), ESCO1(4), ESCO2(4), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PNMT(1), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(8), TYRP1(4) 45187717 164 124 163 54 28 40 48 23 25 0 0.265 1.000 1.000 289 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PAK2(8), PIK3R1(10), PLA2G4A(3), PLCG1(8), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 30228030 159 123 159 39 30 26 46 29 27 1 0.0723 1.000 1.000 290 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(4), AKT3(6), ANKRD6(3), APC(27), AXIN1(11), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(7), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(34), MVP(5), NKD1(8), NKD2(3), PIN1(1), PTPRA(4), SENP2(3), SFRP1(4), TSHB(2), WIF1(1) 30754359 163 123 162 56 22 39 43 33 25 1 0.453 1.000 1.000 291 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(3), GNPAT(3), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(2) 49774432 185 122 184 52 20 38 55 31 41 0 0.113 1.000 1.000 292 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 34 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(7), GNA15(4), GNB1(3), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NCF1(2), NCF2(6), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(13), PLCB1(21), PPP3CA(2), PPP3CB(1), RAF1(3), RELA(2), SYT1(8) 27927977 151 121 149 48 33 24 51 23 20 0 0.366 1.000 1.000 293 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12(3), ALOX12B(5), ALOX15B(5), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP2U1(1), CYP4A22(10), CYP4F2(7), CYP4F3(4), DHRS4(2), EPHX2(4), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), LTA4H(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 28776554 149 121 149 50 22 29 48 22 27 1 0.255 1.000 1.000 294 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 21 ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(5), EPHB2(3), GNAI1(2), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PITX2(2), PTX3(4), RHO(3), RYR1(34) 33910438 158 121 157 60 31 36 38 26 27 0 0.413 1.000 1.000 295 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(4), AKT3(6), ARHGEF11(4), BCL2(1), CDC42(4), DLG4(5), GNA13(2), LPA(16), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PI3(2), PIK3CB(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RDX(1), ROCK1(19), ROCK2(10), SERPINA4(7), SRF(1), TBXA2R(1) 37381120 168 120 168 55 16 43 51 29 29 0 0.435 1.000 1.000 296 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(16), ACACB(20), ACAT2(2), ACOT12(3), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 35530493 149 119 149 58 31 26 44 29 19 0 0.822 1.000 1.000 297 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(5), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PIK3R1(10), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(5), RAF1(3), RELA(2), SHC1(3), SOS1(9), SYT1(8), VAV1(8), ZAP70(2) 32524611 154 119 154 39 31 28 44 22 29 0 0.0542 1.000 1.000 298 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 152 118 152 57 22 40 40 26 24 0 0.575 1.000 1.000 299 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 152 118 152 57 22 40 40 26 24 0 0.575 1.000 1.000 300 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(3), GCNT2(7), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST3GAL5(6), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1) 36951387 159 118 157 61 30 37 53 18 21 0 0.456 1.000 1.000 301 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(17), AR(6), ESR1(6), ESR2(1), ESRRA(5), HNF4A(7), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(2), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(8), NR2F1(3), NR2F2(9), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(5), PGR(5), PPARA(2), PPARD(1), PPARG(1), RARA(4), RARB(6), RARG(11), ROR1(9), RORA(4), RORC(3), RXRA(5), RXRB(3), RXRG(7), THRA(7), THRB(1), VDR(2) 31972831 171 118 169 50 31 30 59 25 25 1 0.130 1.000 1.000 302 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CFLAR(2), DAXX(5), FADD(4), FAF1(2), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(13), RB1(18), RIPK2(6), SPTAN1(24) 30163874 158 117 157 38 18 34 45 24 37 0 0.107 1.000 1.000 303 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(3), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(8), PLCG2(9), PPAP2A(1), PPAP2B(1) 37943344 155 116 154 50 20 26 47 26 36 0 0.282 1.000 1.000 304 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(7), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(37), PFKL(6), PFKM(6), PFKP(6), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2) 29300594 153 116 152 39 26 34 46 22 23 2 0.0186 1.000 1.000 305 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 70 CALR(2), CANX(3), CD4(1), CD74(3), CD8A(2), CD8B(2), CIITA(12), CREB1(1), CTSS(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(9), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(4), LGMN(5), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(2), TAP1(6), TAP2(6), TAPBP(5) 34088361 162 116 159 59 21 42 47 22 30 0 0.480 1.000 1.000 306 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(8), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PIK3CB(7), PITX2(2), PLD1(17), PLD2(1), PLD3(2), VN1R1(2) 34047169 141 116 141 50 17 43 32 27 22 0 0.323 1.000 1.000 307 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 32 BLNK(5), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 28435577 145 114 145 34 30 25 41 25 23 1 0.0230 1.000 1.000 308 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 30 ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(13), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(4), MAPK8(4), MET(4), PAK1(3), PIK3R1(10), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAF1(3), RAP1B(3), SOS1(9), STAT3(6) 28841107 148 113 145 33 23 23 46 32 24 0 0.0347 1.000 1.000 309 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(18), EEF1A2(3), EEF1B2(1), EEF1D(4), EEF1G(2), EEF2(5), EEF2K(6), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G3(9), EIF5(3), EIF5A(5), EIF5B(6), ETF1(3), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1) 33334084 154 112 153 40 17 35 50 28 24 0 0.174 1.000 1.000 310 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(22), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(12), GNB1(3), JUN(1), MAP2K1(5), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(8) 26244007 143 111 142 34 36 28 40 22 17 0 0.00954 1.000 1.000 311 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(5), EPRS(4), FARS2(4), FARSA(1), FARSB(7), GARS(1), HARS(1), HARS2(3), IARS(11), IARS2(3), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), SARS2(1), TARS(6), TARS2(4), VARS(6), VARS2(4), WARS(2), WARS2(8), YARS(7), YARS2(4) 41248531 145 111 145 38 17 30 48 29 21 0 0.117 1.000 1.000 312 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 EGFR(21), ELK1(2), GNAS(12), GNB1(3), IGF1R(13), ITGB1(17), KLK2(2), MAP2K1(5), MAP2K2(6), MKNK1(1), MKNK2(3), MYC(6), NGFR(2), PDGFRA(14), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(3), SOS1(9), STAT3(6) 24297470 148 110 145 32 36 28 48 19 17 0 0.00634 1.000 1.000 313 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(3), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4) 32250973 149 110 149 57 25 40 40 24 20 0 0.489 1.000 1.000 314 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(4), ACAT2(2), ACOX1(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A22(10), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5) 36379858 137 110 137 49 15 32 39 29 22 0 0.595 1.000 1.000 315 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 33 ACTA1(4), ACTN1(6), ACTN2(11), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(5), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAPK8(4), PPP1R12B(5), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), SOS1(9), TLN1(24), VCL(6), ZYX(2) 35055940 164 110 163 43 29 28 59 29 19 0 0.0926 1.000 1.000 316 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(4), ARHGAP4(9), ARHGAP5(10), ARHGAP6(10), ARHGEF1(9), ARHGEF11(4), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(4), PIP5K1B(9), PPP1R12B(5), ROCK1(19), TLN1(24), VCL(6) 34447041 162 110 162 63 25 36 48 34 19 0 0.863 1.000 1.000 317 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(2), ITGA9(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), MAP2K1(5), NR1I3(1), PAK1(3), PDE3A(18), PDE3B(4), PI3(2), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PSME1(1), RIPK3(1), SGCB(3), VASP(1) 34730959 150 109 149 57 18 35 39 27 31 0 0.799 1.000 1.000 318 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(9), GABBR1(3), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM7(19), GRM8(23) 15909035 149 108 147 44 32 29 46 29 13 0 0.0415 1.000 1.000 319 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(5), BLVRA(3), COX10(3), COX15(4), CP(8), CPOX(1), EARS2(5), EPRS(4), FECH(1), FTMT(6), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(2), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UROD(1), UROS(4) 32129286 146 108 146 59 17 23 57 35 14 0 0.952 1.000 1.000 320 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(6), CASP2(3), CASP3(2), CRADD(1), FADD(4), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(18), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TRADD(1), TRAF2(2) 28714380 145 108 144 42 19 26 47 23 30 0 0.353 1.000 1.000 321 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(25), BRCA1(12), BRCA2(22), CHEK1(1), CHEK2(5), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(9), RAD51(1), RAD9A(2), TREX1(4) 32865448 132 107 132 27 9 41 32 29 21 0 0.0328 1.000 1.000 322 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 35 AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(5), GNA11(4), GNAI1(2), GNB1(3), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), SYT1(8) 30749051 139 107 139 48 31 32 42 21 13 0 0.285 1.000 1.000 323 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(3), BTG1(1), CBX3(2), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(3), DNAJA1(3), EIF4G2(9), ETV6(6), G0S2(1), GFRA1(8), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(2), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(3), PPP1R3C(2), PPP2CB(3), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(2), ZFR(5) 27841024 126 107 126 42 17 24 45 23 17 0 0.708 1.000 1.000 324 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(7), EGF(9), EGFR(21), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 24928734 131 107 131 32 17 29 38 22 24 1 0.0493 1.000 1.000 325 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(5), ABAT(7), ACY3(3), ADSL(5), ADSS(4), ADSSL1(6), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(1), DLAT(4), DLD(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1) 28751414 135 107 135 44 19 34 43 20 19 0 0.276 1.000 1.000 326 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(12), BAD(2), BAX(2), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CD40(7), CD40LG(5), CRADD(1), DAXX(5), FADD(4), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(2), NR3C1(6), NTRK1(3), PTPN13(13), RIPK1(2), TFG(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3) 32204174 131 106 131 36 21 35 32 22 21 0 0.102 1.000 1.000 327 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(3), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(5), TAF1(13), TAF10(4), TAF13(1), TAF1L(25), TAF2(8), TAF4(5), TAF4B(5), TAF5(7), TAF5L(4), TAF6(8), TAF6L(2), TAF7(2), TAF7L(5), TAF9(3), TBPL1(2), TBPL2(1) 27383127 136 104 135 46 19 31 39 24 23 0 0.660 1.000 1.000 328 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(3), AOC2(5), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(3), HAL(6), HARS(1), HARS2(3), HDC(4), HEMK1(1), HNMT(2), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(2), UROC1(5) 30069281 131 103 131 36 22 34 43 17 15 0 0.0325 1.000 1.000 329 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT2(2), ACSM1(8), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(5), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(6), L2HGDH(4), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PRDX6(1), RDH11(2), RDH12(4) 30830480 142 103 142 54 17 39 46 25 15 0 0.644 1.000 1.000 330 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(2), F12(2), F13B(13), F2(3), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), LPA(16), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8), VWF(19) 26846529 148 102 147 42 15 40 44 26 23 0 0.174 1.000 1.000 331 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), FUK(3), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(5), MTMR1(1), MTMR2(5), MTMR6(4), PFKFB1(3), PFKFB2(5), PFKFB3(3), PFKFB4(1), PFKL(6), PFKM(6), PFKP(6), PGM2(3), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2) 28192307 119 102 119 36 24 27 32 22 14 0 0.108 1.000 1.000 332 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(7), POLM(2), POLQ(22), PRIM1(3), PRIM2(1), REV1(3), REV3L(25), RFC5(2) 30787268 126 102 125 31 20 29 31 20 26 0 0.0934 1.000 1.000 333 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), LALBA(1), LCT(17), MGAM(37), PFKM(6), PFKP(6), PGM1(5), PGM3(1) 24702425 124 101 123 29 20 30 34 17 21 2 0.0121 1.000 1.000 334 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(8), ATM(16), ATR(25), CCNA1(7), CCND1(4), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), DHFR(3), GSK3B(3), HDAC1(1), RB1(18), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1) 21884065 115 100 114 27 9 22 30 24 30 0 0.161 1.000 1.000 335 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(7), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(10), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), OXCT2(1), PCCA(9), PCCB(1) 32713574 129 100 128 43 16 34 34 27 18 0 0.503 1.000 1.000 336 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7) 19574300 127 100 127 61 34 17 40 21 15 0 0.734 1.000 1.000 337 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(2), BTK(8), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(10), PDK1(3), PPP1R13B(2), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 24676050 134 100 134 46 17 30 42 27 17 1 0.600 1.000 1.000 338 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(11), BTRC(1), CCND1(4), CREBBP(40), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(1), TLE1(8), WIF1(1), WNT1(2) 22357252 144 100 139 36 18 34 36 25 29 2 0.0525 1.000 1.000 339 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(5), APC(27), ATF2(1), AXIN1(11), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(12), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), MAP3K7(8), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), WNT1(2) 26210907 138 99 136 36 20 30 35 29 23 1 0.105 1.000 1.000 340 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(16), ATR(25), BRCA1(12), CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CDC34(4), CHEK1(1), CHEK2(5), GADD45A(1), MDM2(2), MYT1(12), PRKDC(28), RPS6KA1(10), WEE1(1), YWHAH(2), YWHAQ(3) 27511188 135 99 135 28 17 30 39 28 21 0 0.0540 1.000 1.000 341 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 22 ACTA1(4), CAPN1(3), CAPN2(6), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(21), ITGA1(4), ITGB1(17), MYLK(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTK2(10), PXN(3), TLN1(24) 24025925 130 99 128 43 24 23 40 25 17 1 0.444 1.000 1.000 342 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), BCL2(1), EGFR(21), IGF1R(13), MYC(6), POLR2A(11), PRKCA(7), RB1(18), TEP1(16), TERF1(5), TERT(4), TNKS(8), XRCC5(4) 20871413 116 99 114 39 14 30 30 18 23 1 0.266 1.000 1.000 343 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(8), ADRBK2(5), ARRB2(3), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(5), CLCA2(6), CLCA4(6), CNGA3(10), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(3), PRKG1(8), PRKG2(2), PRKX(1) 23203428 120 98 120 45 18 27 35 23 17 0 0.548 1.000 1.000 344 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(14), PIK3R1(10), PLD1(17), PPP1R12B(5), RALBP1(5), RPS6KB1(5), TRIO(22), VAV1(8), WASF1(3) 24567635 130 98 130 52 21 29 43 15 22 0 0.896 1.000 1.000 345 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 AGT(4), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(21), ELK1(2), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK8(4), MEF2A(3), MEF2B(5), MEF2D(1), PAK1(3), PRKCA(7), PTK2(10), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 23034129 113 97 113 34 18 19 40 25 11 0 0.336 1.000 1.000 346 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), NACA(25), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5) 38518834 143 97 142 52 15 38 48 18 23 1 0.848 1.000 1.000 347 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(3), CEBPB(1), DAZL(3), DMC1(2), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), NCOR1(21), NRIP1(9), PGR(5), PRLR(8), PTGER2(5), SMPD1(2), VDR(2), ZP2(6) 26643751 128 97 124 37 15 32 39 21 21 0 0.225 1.000 1.000 348 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(5), ADCY3(8), ADCY9(9), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(8), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6) 28098922 128 96 128 35 24 28 36 21 19 0 0.0589 1.000 1.000 349 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 19 ARHGAP5(10), DIAPH1(7), FYN(5), GSN(5), ITGA1(4), ITGB1(17), MAP2K1(5), MYLK(8), PFN1(1), PIK3R1(10), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), TLN1(24) 25884604 134 95 133 36 21 23 36 29 25 0 0.238 1.000 1.000 350 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(7), ACACA(16), ACACB(20), ACADM(3), ACAT2(2), ACSS1(5), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 30167579 123 95 123 47 23 22 36 24 18 0 0.800 1.000 1.000 351 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(7), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(14), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 22979223 115 95 115 27 17 26 35 14 23 0 0.0409 1.000 1.000 352 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(12), IRAK1(3), JUN(1), LY96(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(4), TLR2(3), TLR3(2), TLR4(16), TLR6(4), TLR7(8), TLR9(7), TOLLIP(2), TRAF6(3) 27776437 120 95 119 46 19 25 38 14 24 0 0.710 1.000 1.000 353 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(2), DLG4(5), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(8) 19451476 114 94 114 41 23 28 30 20 13 0 0.213 1.000 1.000 354 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 28074114 119 94 119 41 22 23 36 24 14 0 0.589 1.000 1.000 355 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(10), JAK1(11), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(5), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), STAT6(5), TYK2(8) 26383894 120 94 120 44 19 24 39 24 14 0 0.628 1.000 1.000 356 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(2), ATF1(3), CDC42(4), CREB1(1), CREB3(1), CREB5(8), DUSP1(2), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(6), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3) 24848235 114 94 112 35 17 24 32 23 18 0 0.320 1.000 1.000 357 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(27), AXIN1(11), CCND1(4), CD14(1), CTNNB1(6), DVL1(7), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(8), LEF1(6), LY96(2), NFKB1(5), PDPK1(4), PIK3R1(10), RELA(2), TIRAP(1), TLR4(16), TOLLIP(2), WNT1(2) 21801708 132 93 130 41 18 34 33 19 27 1 0.229 1.000 1.000 358 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(2), AVP(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(13), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), NFATC1(10), NFATC2(15), PIK3R1(10), PPP3CA(2), PPP3CB(1), SYT1(8), YWHAH(2) 24165674 115 93 115 41 21 23 28 28 15 0 0.345 1.000 1.000 359 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 125 92 122 38 23 26 31 21 23 1 0.202 1.000 1.000 360 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 19 CCR3(6), CFL1(2), GNAS(12), GNB1(3), LIMK1(5), MAP2K1(5), NOX1(6), PIK3C2G(13), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2(10), RAF1(3), ROCK2(10) 18294635 108 92 106 32 18 21 39 14 16 0 0.445 1.000 1.000 361 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 125 92 122 38 23 26 31 21 23 1 0.202 1.000 1.000 362 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(4), GIPR(2), GLP1R(2), GLP2R(3), GPR64(6), LPHN1(11), LPHN2(11), LPHN3(24), SCTR(2), VIPR1(1), VIPR2(6) 20246798 120 92 120 44 15 15 36 38 16 0 0.641 1.000 1.000 363 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 31 AKT1(2), BAD(2), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), IL2RA(2), IL2RB(3), IRS1(4), JAK1(11), JAK3(6), MYC(6), NMI(6), PIK3R1(10), PTPN6(3), RAF1(3), RPS6KB1(5), SHC1(3), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 24980870 110 92 108 31 15 32 29 16 18 0 0.0560 1.000 1.000 364 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 36 ATF2(1), CDC42(4), CREB1(1), DAXX(5), DDIT3(1), ELK1(2), HMGN1(1), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RIPK1(2), RPS6KA5(5), SHC1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 26494513 101 92 98 37 18 22 30 14 17 0 0.722 1.000 1.000 365 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(27), AXIN1(11), CREBBP(40), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(6), PITX2(2), TRRAP(22), WNT1(2) 21511275 135 92 133 31 23 29 32 27 22 2 0.0101 1.000 1.000 366 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), GAMT(2), GATM(4), GLUD1(4), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3) 33577243 117 91 117 39 22 25 33 21 16 0 0.367 1.000 1.000 367 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(22), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(8), PDGFRA(14), PIK3R1(10), PLCB1(21), PRKCA(7), PTK2(10), SMPD1(2) 18363045 108 91 106 30 15 23 36 17 17 0 0.124 1.000 1.000 368 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(10) 22321126 115 91 114 44 15 19 43 22 15 1 0.734 1.000 1.000 369 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(5), ALAS2(5), AMT(2), AOC2(5), AOC3(5), ATP6V0C(2), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), MAOA(1), MAOB(1), PLCB2(7), PLCG1(8), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(2), TARS(6) 31847778 117 90 117 47 28 20 40 19 10 0 0.690 1.000 1.000 370 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(10), ATP4B(2), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(7), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4) 28976279 116 90 114 27 16 29 34 24 13 0 0.0248 1.000 1.000 371 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 21 ATF2(1), BCR(2), BLNK(5), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK8IP3(8), PAPPA(13), RPS6KA1(10), RPS6KA3(4), SHC1(3), SOS1(9), SYK(8), VAV1(8), VAV2(4), VAV3(4) 23230646 107 90 107 27 25 14 30 15 23 0 0.123 1.000 1.000 372 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(4), IRS2(6), JAK1(11), JAK3(6), MAP4K1(4), PDK1(3), PIK3CD(8), PIK3R1(10), PPP1R13B(2), RAF1(3), SHC1(3), SOCS1(1), SOS1(9), SOS2(11), STAT6(5) 25670668 114 90 114 36 19 24 32 24 15 0 0.260 1.000 1.000 373 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), AOX1(10), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), PCCA(9), PCCB(1), SDS(1) 27373833 108 90 107 34 11 22 32 25 18 0 0.550 1.000 1.000 374 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(7), ADC(1), ALDH5A1(1), CAD(5), CPS1(13), EARS2(5), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 30042916 109 89 109 51 19 25 26 20 19 0 0.932 1.000 1.000 375 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(7), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), MLYCD(3), SDS(1), SMS(3), UPB1(2) 22098133 114 88 114 31 12 30 38 22 12 0 0.125 1.000 1.000 376 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(16), C5(11), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELP(15), SELPLG(1), VCAM1(10) 17391670 115 88 114 35 12 32 35 17 19 0 0.155 1.000 1.000 377 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ATP6V0C(2), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADHA(3), PLOD1(3), PLOD2(8), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(2) 28166869 110 88 110 45 19 18 28 24 21 0 0.780 1.000 1.000 378 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PIK3CD(8), PIK3R1(10), SYT1(8), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 23475983 101 88 101 28 21 17 27 12 24 0 0.0927 1.000 1.000 379 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(7), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 25172960 103 87 103 32 17 17 33 20 16 0 0.501 1.000 1.000 380 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(3), BAD(2), BRAF(10), CREB1(1), CREB3(1), CREB5(8), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(6), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MKNK1(1), MKNK2(3), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), SHC1(3), SOS1(9), SOS2(11), TRAF3(6) 21917671 121 87 120 32 26 22 37 21 15 0 0.104 1.000 1.000 381 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(2), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(8), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 21552481 103 86 102 30 13 24 36 17 13 0 0.224 1.000 1.000 382 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(3), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(3), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(8), TAF7(2), TAF9(3), TBP(2) 26651829 112 86 112 39 9 26 28 23 26 0 0.621 1.000 1.000 383 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(5), AMT(2), AOC2(5), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SARS2(1), SDS(1), SHMT1(1), SHMT2(2), TARS(6), TARS2(4) 32368566 109 85 109 45 27 20 39 15 7 1 0.720 1.000 1.000 384 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 20 CHUK(6), CREBBP(40), DUSP1(2), IKBKB(12), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K7(8), MAPK11(4), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TLR2(3) 17962099 99 85 97 28 14 16 29 18 21 1 0.296 1.000 1.000 385 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), COMT(2), DBH(8), DCT(4), DDC(7), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(3), TPO(11), TYR(8) 24089511 104 85 103 40 18 25 31 12 18 0 0.517 1.000 1.000 386 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), RPE(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), XYLB(3) 20775690 104 84 104 40 14 15 39 25 11 0 0.876 1.000 1.000 387 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(3), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(3) 26180325 99 84 99 44 23 20 20 17 19 0 0.801 1.000 1.000 388 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(10), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(8), VIP(1), VIPR2(6) 21280054 103 84 101 36 24 20 31 16 12 0 0.369 1.000 1.000 389 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), ALG9(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(2), RPN1(2), RPN2(6), ST6GAL1(3), STT3B(2) 32231042 113 83 113 41 15 23 38 18 19 0 0.668 1.000 1.000 390 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(17), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(4), LCAT(2), LDLR(6), LIPC(5), LPL(4), LRP1(34), SCARB1(1), SOAT1(5) 20853162 92 83 91 29 12 21 27 19 13 0 0.357 1.000 1.000 391 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(10), PXN(3), STAT1(7), TLN1(24) 20207506 104 82 104 28 13 30 25 20 16 0 0.176 1.000 1.000 392 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFAT5(13), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5) 27079943 103 82 103 40 10 36 27 17 13 0 0.519 1.000 1.000 393 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GH1(4), GHR(8), INSR(3), IRS1(4), JAK2(5), MAP2K1(5), PIK3R1(10), PLCG1(8), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5) 22651414 96 81 96 22 15 26 33 11 11 0 0.0192 1.000 1.000 394 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(7), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HIBCH(2), MLYCD(3), SMS(3), UPB1(2) 20536304 99 81 99 29 11 30 31 19 8 0 0.167 1.000 1.000 395 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(3), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(3), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(4), WBSCR17(9) 24558538 105 80 105 38 17 28 28 15 16 1 0.604 1.000 1.000 396 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), FADD(4), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TRADD(1), TRAF2(2) 27021042 101 79 99 26 19 26 26 14 16 0 0.0776 1.000 1.000 397 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(22), AKT1(2), BAD(2), BAX(2), BCL2(1), BCL2L1(2), CSF2RB(8), IGF1(1), IGF1R(13), IL3(1), IL3RA(6), KIT(11), KITLG(1), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), YWHAH(2) 15019889 100 79 99 30 16 26 25 17 16 0 0.119 1.000 1.000 398 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(9), EGFR(21), FOS(6), JUN(1), MYC(6), NFKB1(5), PLCG1(8), PRKCA(7), RELA(2) 15307125 87 79 85 26 12 22 31 14 7 1 0.214 1.000 1.000 399 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(12), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), FADD(4), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2) 24567054 94 79 94 25 18 23 22 12 19 0 0.0803 1.000 1.000 400 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(7), CYP4F3(4), EPX(10), GGT1(4), LTA4H(1), MPO(8), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5), TPO(11) 21251910 96 79 95 46 22 18 27 11 18 0 0.849 1.000 1.000 401 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB3(1), CREB5(8), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5) 21252265 95 79 94 22 13 24 25 15 18 0 0.0548 1.000 1.000 402 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(4), ARSE(2), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD1(2), SMPD3(2), SMPD4(5), SPHK2(5), SPTLC1(5), SPTLC2(3), UGCG(1) 27239418 95 78 95 44 20 24 26 12 13 0 0.716 1.000 1.000 403 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(2), CDC23(4), CDC26(1), CDC27(8), CUL1(11), CUL2(3), FBXW11(3), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(3), SMURF2(6), TCEB1(2), TCEB2(1), UBA1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(1), WWP1(7), WWP2(5) 28013249 96 78 96 37 9 30 21 21 15 0 0.805 1.000 1.000 404 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(2), TGFB2(3), TGFB3(1), TOLLIP(2), TRAF6(3) 22629746 91 78 90 34 18 17 26 12 18 0 0.723 1.000 1.000 405 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(8), DLG4(5), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK7(6), MAPK8(4), MYEF2(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RAF1(3), RASAL1(5), TEC(2), VAV1(8) 20396850 94 78 94 23 8 21 26 18 20 1 0.0794 1.000 1.000 406 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 15 CBL(3), EGF(9), EGFR(21), MAP2K1(5), PTPRB(24), RAF1(3), SHC1(3), SOS1(9), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2) 16585991 87 77 87 26 14 14 28 19 11 1 0.405 1.000 1.000 407 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 BCAR1(3), CRK(2), CXCL12(6), CXCR4(2), GNAI1(2), GNB1(3), MAP2K1(5), NFKB1(5), PIK3C2G(13), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PTK2B(4), PXN(3), RAF1(3), RELA(2) 18542196 88 76 87 29 15 14 26 15 18 0 0.628 1.000 1.000 408 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(7), ACO2(3), CLYBL(1), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), OGDHL(12), PC(14), PCK1(1), PCK2(4), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 22686178 94 76 93 37 19 18 29 15 13 0 0.639 1.000 1.000 409 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(7), ADSL(5), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), PC(14) 19803813 89 75 89 28 15 17 30 14 13 0 0.299 1.000 1.000 410 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(8) 18450820 85 75 85 31 14 16 25 19 11 0 0.491 1.000 1.000 411 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), EPRS(4), GAMT(2), GATM(4), GLUD1(4), GLUD2(10), GOT1(1), GOT2(3), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 27312081 95 75 95 33 20 17 23 22 13 0 0.529 1.000 1.000 412 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(40), DAXX(5), PAX3(6), PML(4), RARA(4), RB1(18), SIRT1(2), SP100(8), TNFRSF1A(1), TNFRSF1B(2) 13524169 90 75 89 27 9 17 25 13 25 1 0.375 1.000 1.000 413 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(3), NCOA1(7), NCOA2(8), NCOA3(9), NCOR2(24), POLR2A(11), RARA(4), RXRA(5), TBP(2) 18982669 93 75 93 25 12 21 25 23 12 0 0.110 1.000 1.000 414 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(2), CYP11B1(7), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14) 20760596 89 74 89 34 18 14 27 19 11 0 0.699 1.000 1.000 415 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(7), ALDH5A1(1), CAD(5), CPS1(13), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), GMPS(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 25243521 87 74 87 41 13 21 21 17 15 0 0.933 1.000 1.000 416 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2) 24044556 89 74 89 37 17 20 28 17 7 0 0.774 1.000 1.000 417 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(2), AP2A1(3), AP2M1(3), BAD(2), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PLCG1(8), PRKCE(3), PRKCZ(3), RAB5A(3), RPS6KB1(5), VAV2(4) 18709470 91 74 90 31 12 17 30 13 18 1 0.497 1.000 1.000 418 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(7), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(2), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1) 19612415 90 73 90 32 10 26 28 12 14 0 0.553 1.000 1.000 419 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(3), AGT(4), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), REN(3) 18588701 89 72 88 39 10 26 28 15 10 0 0.960 1.000 1.000 420 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), GCK(4), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), KHK(3), MPI(5), PFKFB1(3), PFKFB3(3), PFKFB4(1), PFKM(6), PFKP(6), PMM2(2), SORD(2), TPI1(4) 18131556 80 72 80 23 14 23 18 14 11 0 0.0729 1.000 1.000 421 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(2), CSF1R(2), DDX20(4), E2F4(2), ETS1(4), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), JUN(1), NCOR2(24), RBL1(11), RBL2(6), SIN3A(6), SIN3B(11) 19454627 92 71 92 29 16 27 23 14 12 0 0.157 1.000 1.000 422 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(14), BAIAP2(3), CASP1(2), CASP3(2), CASP7(3), GAPDH(2), INSR(3), ITCH(7), MAGI1(14), MAGI2(20), RERE(7), WWP1(7), WWP2(5) 17353403 89 71 89 36 13 26 22 16 12 0 0.834 1.000 1.000 423 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(9), GNA12(2), GNA13(2), GNB1(3), MYLK(8), PLCB1(21), PPP1R12B(5), PRKCA(7), ROCK1(19) 15718096 86 71 85 30 15 16 28 16 11 0 0.653 1.000 1.000 424 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(17), AP2A1(3), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(5), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(9), SYT1(8) 16499519 81 71 81 35 11 15 27 15 13 0 0.922 1.000 1.000 425 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(4), IKBKB(12), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(16), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 18588574 83 71 82 30 15 17 26 13 12 0 0.560 1.000 1.000 426 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 25 BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP3K1(6), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 20509374 86 71 86 30 21 12 31 12 10 0 0.599 1.000 1.000 427 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), GHR(8), IRS1(4), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3R1(10), PRKCA(7), RPS6KB1(5) 18642654 89 70 88 26 3 25 23 14 24 0 0.449 1.000 1.000 428 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(5), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2) 18542350 82 70 82 24 11 18 31 12 10 0 0.183 1.000 1.000 429 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(4), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(13), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3) 22360443 80 70 80 25 18 21 22 11 8 0 0.221 1.000 1.000 430 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(6), CHIT1(4), CTBS(3), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(5), HK3(8), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(4) 21800018 82 70 82 28 21 17 21 8 15 0 0.402 1.000 1.000 431 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4) 18172097 85 70 85 30 11 16 36 12 9 1 0.498 1.000 1.000 432 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), HAL(6) 16146378 79 70 79 33 16 17 21 16 9 0 0.834 1.000 1.000 433 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(8), ACE2(3), AGT(4), AGTR2(2), CMA1(5), CPA3(7), CTSA(2), CTSG(1), ENPEP(14), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1) 15535590 83 70 83 32 11 13 32 15 12 0 0.697 1.000 1.000 434 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), P4HB(1), SLC23A1(3), SLC23A2(7), SLC2A1(4), SLC2A3(2) 18991315 89 70 88 40 10 27 24 17 11 0 0.948 1.000 1.000 435 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(4), DARS(5), EPRS(4), FARS2(4), GARS(1), HARS(1), IARS(11), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(7) 24299185 84 69 84 21 7 14 33 21 9 0 0.231 1.000 1.000 436 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5), TSC1(5), TSC2(8) 18753629 87 69 86 22 6 22 23 10 26 0 0.275 1.000 1.000 437 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(6), ACTN2(11), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(10), PXN(3), VCL(6) 14613213 85 68 83 36 11 18 30 13 12 1 0.896 1.000 1.000 438 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3R1(10), RAF1(3), SOS1(9), STAT1(7), STAT5A(3), STAT5B(5) 19413464 80 68 78 25 9 24 25 8 14 0 0.293 1.000 1.000 439 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(30), PLCB1(21), PPP1CA(1), PPP1R1B(2), PPP3CA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 12136445 83 67 81 30 16 21 24 18 4 0 0.337 1.000 1.000 440 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAPN2(6), CAPNS1(2), CAPNS2(2), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(10), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(8) 14816740 78 67 77 26 13 17 21 19 8 0 0.308 1.000 1.000 441 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(5), GADD45A(1), JUN(1), MAPK8(4), MDM2(2), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(2) 22063335 78 66 77 24 6 20 24 14 14 0 0.656 1.000 1.000 442 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(2), TGFB2(3), TGFB3(1) 15203829 79 66 78 26 10 13 26 14 16 0 0.354 1.000 1.000 443 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(5), IKBKB(12), JAK2(5), LIN7A(5), NFKB1(5), NFKBIA(1), RB1(18), RELA(2), TNFRSF1A(1), TNFRSF1B(2), USH1C(7), WT1(3) 13216630 75 66 74 23 6 12 24 10 23 0 0.421 1.000 1.000 444 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(8) 15979389 73 63 73 25 15 14 22 15 7 0 0.410 1.000 1.000 445 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(7), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), METTL2B(4), METTL6(3), PAPSS1(6), PAPSS2(6), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(3) 18938494 77 62 77 23 18 21 19 12 7 0 0.132 1.000 1.000 446 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(3) 15532358 72 62 72 31 13 15 14 16 14 0 0.802 1.000 1.000 447 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(6), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7) 12508670 71 62 71 23 15 14 19 11 12 0 0.269 1.000 1.000 448 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), SELE(7), SELL(2), SELP(15) 12108439 82 62 81 29 9 18 22 12 21 0 0.525 1.000 1.000 449 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), HAL(6) 14444489 68 62 68 28 12 16 18 15 7 0 0.804 1.000 1.000 450 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3) 15543179 68 62 68 25 11 13 19 16 9 0 0.458 1.000 1.000 451 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(3), CP(8), CPOX(1), EPRS(4), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UROD(1), UROS(4) 20864118 70 62 70 35 8 11 25 17 9 0 0.987 1.000 1.000 452 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), ESCO1(4), ESCO2(4), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11) 26016506 76 61 75 37 15 16 27 7 11 0 0.924 1.000 1.000 453 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CMBL(2), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(10), PON2(1), PON3(6) 13706360 70 61 69 27 10 10 23 13 14 0 0.773 1.000 1.000 454 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), OPLAH(6) 16828021 72 61 72 31 14 18 20 13 7 0 0.610 1.000 1.000 455 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(20), AKT1(2), ATM(16), BAX(2), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(4), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(2), NQO1(3) 15197591 67 61 67 21 11 14 18 10 14 0 0.568 1.000 1.000 456 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(6), CRADD(1), IKBKB(12), JUN(1), LTA(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 18415390 67 61 67 25 13 12 21 9 12 0 0.665 1.000 1.000 457 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(4), MAPK14(2), NFATC1(10), NFATC2(15), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9250727 63 60 63 25 19 13 13 9 9 0 0.324 1.000 1.000 458 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NFKB1(5), PIK3R1(10), RB1(18), RELA(2), SP1(3) 12579283 65 60 65 22 10 7 17 5 26 0 0.821 1.000 1.000 459 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15) 15808855 64 59 64 31 14 11 23 9 7 0 0.929 1.000 1.000 460 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6) 17108010 64 59 64 22 12 14 17 7 14 0 0.448 1.000 1.000 461 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(22), CFTR(14), GNAS(12), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1) 9965823 65 58 64 19 18 14 18 9 6 0 0.236 1.000 1.000 462 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(22), GNAS(12), GNB1(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 11662340 69 58 68 22 20 11 20 10 8 0 0.481 1.000 1.000 463 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(10), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(4), QPRT(1) 16385816 70 58 70 36 9 9 23 18 11 0 0.984 1.000 1.000 464 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX2(2), PRDX6(1), TAT(1), TPO(11) 16695952 68 58 67 32 15 15 23 6 9 0 0.769 1.000 1.000 465 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(22), GNAS(12), PLCE1(21), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAP2B(2) 11244945 73 58 72 22 20 15 21 8 9 0 0.246 1.000 1.000 466 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(9), COMT(2), DBH(8), DDC(7), GAD1(4), GAD2(7), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(2) 10979411 64 57 64 28 10 13 23 5 13 0 0.739 1.000 1.000 467 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22) 12728592 61 57 61 16 11 13 14 7 16 0 0.155 1.000 1.000 468 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTAP(4), MTFMT(4), MTR(8), TAT(1) 15762418 72 57 72 25 11 16 15 14 16 0 0.343 1.000 1.000 469 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(11), ENPP6(5), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1) 17648206 76 57 76 21 6 21 23 14 12 0 0.156 1.000 1.000 470 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(8), TPI1(4) 15364646 65 57 65 23 10 14 23 11 7 0 0.519 1.000 1.000 471 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(30), MAP2(21), PPP1CA(1), PRKACB(3), PRKACG(3), PRKAR2B(3), PRKCE(3) 13782702 64 56 63 20 4 7 24 11 18 0 0.819 1.000 1.000 472 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(10), CR2(9), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19) 11557965 64 56 63 29 4 17 17 10 16 0 0.910 1.000 1.000 473 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(6), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2), VNN1(3) 13169729 71 56 71 29 8 15 23 16 9 0 0.823 1.000 1.000 474 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(4), ARSE(2), ASAH1(1), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD1(2), SPTLC1(5), SPTLC2(3), UGCG(1) 18358974 63 55 63 33 14 16 17 6 10 0 0.894 1.000 1.000 475 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(9), ABCG2(4), BCHE(5), CES1(7), CES2(11), CYP3A4(6), CYP3A5(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1) 17365735 66 55 66 35 13 10 26 9 8 0 0.951 1.000 1.000 476 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(16), CPT1A(6), LEP(1), LEPR(20), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2) 10992549 59 55 59 30 9 8 21 9 12 0 0.989 1.000 1.000 477 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), SOAT2(2) 17667332 65 54 65 27 10 11 20 15 9 0 0.842 1.000 1.000 478 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(8), F2(3), F2R(4), FGA(10), FGB(4), FGG(6), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8) 10177414 68 54 68 24 6 17 18 9 18 0 0.669 1.000 1.000 479 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(7), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), HADHA(3), SH3GLB1(2), YOD1(4) 23523236 65 54 65 27 3 14 22 17 9 0 0.874 1.000 1.000 480 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1) 17836859 71 54 71 21 6 16 20 13 16 0 0.351 1.000 1.000 481 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(2), IL22RA1(4), IL22RA2(1), JAK1(11), JAK2(5), JAK3(6), SOCS3(1), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8) 13969727 64 54 64 26 8 19 18 10 9 0 0.527 1.000 1.000 482 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(4), IARS(11), IARS2(3), ILVBL(6), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(6), VARS2(4) 14172257 64 53 64 23 3 24 21 7 9 0 0.571 1.000 1.000 483 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(7), ST3GAL6(4), ST8SIA1(3) 12353169 57 53 55 20 9 15 23 5 5 0 0.356 1.000 1.000 484 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(2), ATIC(6), DHFR(3), FTCD(3), GART(4), MTFMT(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 14376024 64 53 64 24 9 6 25 10 13 1 0.762 1.000 1.000 485 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(6), BIRC2(2), BIRC3(2), CASP3(2), CFLAR(2), FADD(4), JUN(1), MAP2K4(2), MAP3K3(3), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR2C2(1), RALBP1(5), RIPK1(2), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 19926143 68 53 67 23 16 20 16 7 9 0 0.304 1.000 1.000 486 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(4), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), GAMT(2), GATM(4), GLUD1(4), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3) 13320479 55 53 55 16 15 15 14 7 4 0 0.152 1.000 1.000 487 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(6), IFNG(2), IKBKB(12), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2) 14780390 60 52 60 20 9 9 21 7 14 0 0.624 1.000 1.000 488 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(3), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(14), PCK1(1), SDHA(7), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 15649727 61 52 60 22 10 16 18 10 7 0 0.413 1.000 1.000 489 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(11), EGF(9), EGFR(21), HGS(2), RAB5A(3), TF(5), TFRC(7) 9752921 58 52 58 21 5 13 17 12 10 1 0.764 1.000 1.000 490 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), PHPT1(1), TYR(8) 11427331 59 52 59 18 11 6 24 7 11 0 0.641 1.000 1.000 491 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), GOSR1(4), GOSR2(2), SNAP25(3), STX11(6), STX12(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1) 12701549 59 52 58 18 11 13 17 4 14 0 0.320 1.000 1.000 492 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3) 13818226 55 51 55 18 10 12 15 5 13 0 0.472 1.000 1.000 493 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(2) 16075307 59 51 59 27 8 8 27 11 5 0 0.952 1.000 1.000 494 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8) 14191291 60 51 60 23 5 13 18 8 16 0 0.772 1.000 1.000 495 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), JAK1(11), PTPRU(9), REG1A(13), STAT1(7), STAT2(6), TYK2(8) 9506297 57 51 57 22 9 15 15 7 11 0 0.550 1.000 1.000 496 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD5(1), CD7(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(7), TLR2(3), TLR4(16), TLR7(8), TLR9(7) 14151845 59 50 59 25 9 12 17 9 12 0 0.660 1.000 1.000 497 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), PGD(2) 13740469 58 50 58 22 13 14 14 10 7 0 0.470 1.000 1.000 498 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(2), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(13), INPPL1(9), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5) 12712212 63 50 62 18 9 18 13 7 16 0 0.301 1.000 1.000 499 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(16), ACACB(20), FASN(10), MCAT(3), OLAH(3), OXSM(3) 12070202 55 49 55 23 13 12 14 11 5 0 0.658 1.000 1.000 500 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(20), ABCB11(9), ABCB4(13), ABCC1(5), ABCC3(4), GSTP1(1) 10885488 52 49 52 24 7 10 18 3 14 0 0.806 1.000 1.000 501 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(2), ATIC(6), ATP6V0C(2), DHFR(3), GART(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 13581168 59 49 59 25 9 5 26 9 9 1 0.894 1.000 1.000 502 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 13 AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), PDK1(3), PIK3CD(8), PTK2B(4), RBL2(6), SHC1(3), SOS1(9) 12749744 51 49 51 17 12 9 15 11 4 0 0.469 1.000 1.000 503 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPHN(5), NSF(1), UBQLN1(2) 9111054 58 48 57 26 5 11 21 9 12 0 0.953 1.000 1.000 504 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4) 10912235 54 48 54 23 11 14 12 10 7 0 0.644 1.000 1.000 505 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELE(7), SELL(2) 9205718 59 48 58 23 7 14 14 8 16 0 0.634 1.000 1.000 506 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2) 10610737 58 48 58 22 7 10 19 14 8 0 0.775 1.000 1.000 507 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(21), PLCB2(7), PRL(4), TRH(2), VIP(1) 8460897 52 48 51 23 6 7 24 10 5 0 0.844 1.000 1.000 508 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPX1(3), PRKCE(3), SOD1(1) 5981221 55 47 54 19 5 8 22 8 12 0 0.743 1.000 1.000 509 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTR(8) 13211457 59 47 59 23 10 14 13 12 10 0 0.518 1.000 1.000 510 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(5), HK3(8), PGM3(1), RENBP(5), UAP1(4) 12878816 48 46 48 16 13 14 9 6 6 0 0.352 1.000 1.000 511 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(12), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), GZMB(2), LMNA(1), LMNB1(1), LMNB2(8), PRF1(4) 13797785 54 46 54 14 10 13 9 13 9 0 0.211 1.000 1.000 512 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(4), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGW(2), PIGX(2), PIGZ(2) 18076612 53 46 53 32 8 13 16 6 10 0 0.989 1.000 1.000 513 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14) 13372374 49 46 49 25 9 4 15 15 6 0 0.963 1.000 1.000 514 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(2), AKT2(4), AKT3(6), ELK1(2), MAP2K1(5), MAP2K2(6), NGFR(2), NTRK1(3), PIK3CD(8), SHC1(3), SOS1(9) 10293649 50 46 50 17 15 6 15 11 3 0 0.482 1.000 1.000 515 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), BAD(2), CHRNB1(1), CHRNG(9), MUSK(7), PIK3R1(10), PTK2(10), PTK2B(4), TERT(4), YWHAH(2) 10798624 51 45 51 23 8 10 13 9 11 0 0.786 1.000 1.000 516 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(3), LCT(17), MPI(5), PGM1(5), PYGL(9), PYGM(8), TPI1(4), TREH(1) 10134954 56 45 56 19 10 15 16 8 7 0 0.263 1.000 1.000 517 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 15482055 50 45 50 25 15 8 12 6 9 0 0.825 1.000 1.000 518 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(3), AFMID(6), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 10171935 51 45 51 16 6 13 17 8 6 1 0.483 1.000 1.000 519 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(3), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(2), SLC25A20(3) 12775859 51 45 51 20 5 13 11 12 10 0 0.762 1.000 1.000 520 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(5), GALNT2(7), GALNT3(6), GALNT6(4), GALNT7(3), GALNT8(6), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(9) 10976813 47 44 47 20 8 14 12 5 7 1 0.699 1.000 1.000 521 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4) 13746524 49 43 49 18 9 10 16 9 5 0 0.565 1.000 1.000 522 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 19 BAD(2), BAX(2), BCL2(1), FADD(4), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), SMPD1(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 14253683 50 43 50 23 12 6 19 6 7 0 0.910 1.000 1.000 523 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(5), AOC3(5), CES1(7), DDHD1(5), ESCO1(4), ESCO2(4), LIPA(3), PLA1A(8), PRDX6(1), SH3GLB1(2) 19292782 49 43 49 12 4 12 19 9 5 0 0.268 1.000 1.000 524 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(10), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5E(1), QPRT(1) 11070058 51 43 51 27 4 7 19 13 8 0 0.981 1.000 1.000 525 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(3), FOS(6), JUN(1), OPRK1(7), POLR2A(11), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9805793 45 42 45 17 9 12 12 7 5 0 0.497 1.000 1.000 526 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(9), EGFR(21), ERBB3(14), NRG1(4) 7831161 48 42 48 17 5 12 12 13 5 1 0.686 1.000 1.000 527 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(8), IRS1(4), JAK1(11), JAK3(6), RPS6KB1(5), SHC1(3), STAT6(5) 11221458 45 42 45 13 7 11 12 8 7 0 0.220 1.000 1.000 528 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(3) 15241478 55 42 55 18 9 9 15 9 13 0 0.448 1.000 1.000 529 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(4), DHFR(3), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(1) 9527178 46 42 46 16 12 5 18 2 9 0 0.554 1.000 1.000 530 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD8A(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8175122 45 42 45 22 4 8 10 9 14 0 0.872 1.000 1.000 531 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(5), ARFGEF2(14), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(3) 12328265 47 41 47 14 5 17 12 4 9 0 0.219 1.000 1.000 532 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(3), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 9711714 45 41 45 16 6 10 16 7 5 1 0.666 1.000 1.000 533 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(6), GREB1(19), HSPB2(2), MTA1(8), MTA3(2), PDZK1(1), TUBA8(2) 8345615 46 41 46 22 12 3 17 8 6 0 0.852 1.000 1.000 534 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8577979 44 41 44 22 3 8 10 10 13 0 0.885 1.000 1.000 535 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), WASF1(3), WASF2(5), WASF3(7), WASL(2) 11260187 46 40 46 22 10 10 12 9 5 0 0.942 1.000 1.000 536 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(5), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2), VKORC1(2) 14668829 45 40 45 18 11 11 10 5 8 0 0.577 1.000 1.000 537 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(5), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1) 9584644 48 40 48 22 20 8 14 2 4 0 0.728 1.000 1.000 538 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(2), YOD1(4) 19773448 44 40 44 16 2 11 12 12 7 0 0.675 1.000 1.000 539 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(14), PIK3R1(10), WASL(2) 8177237 41 39 41 16 5 8 13 6 9 0 0.899 1.000 1.000 540 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 12562163 43 39 43 21 12 6 12 6 7 0 0.829 1.000 1.000 541 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(10), MPO(8), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8827971 42 38 41 22 15 6 15 3 3 0 0.892 1.000 1.000 542 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(6) 12149192 43 38 43 15 3 8 16 11 5 0 0.710 1.000 1.000 543 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(2), CAT(4), EPX(10), MPO(8), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8975989 44 38 43 21 14 6 16 5 3 0 0.830 1.000 1.000 544 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), FDXR(4), SHMT1(1) 12146771 50 38 50 14 6 9 18 9 8 0 0.375 1.000 1.000 545 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(5), SELL(2), SPN(3), TGFB1(2), TGFB2(3), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10031334 43 38 43 19 6 12 11 10 4 0 0.658 1.000 1.000 546 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(3), PER3(7) 12977866 44 37 44 17 11 11 10 9 3 0 0.573 1.000 1.000 547 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(2), IL1A(1), IL6(2), JAK1(11), STAT1(7), STAT3(6), STAT5A(3) 9254119 41 37 41 20 3 15 11 6 6 0 0.651 1.000 1.000 548 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), JAK2(5), STAT4(6), TYK2(8) 11170748 45 37 45 19 4 10 14 7 10 0 0.789 1.000 1.000 549 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), TYR(8) 7388664 41 37 41 14 5 6 19 4 7 0 0.699 1.000 1.000 550 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(2), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 11090459 37 37 36 13 4 9 12 1 11 0 0.598 1.000 1.000 551 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(3), RPL8(1), RPS13(2), RPS15A(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS28(1), RPS3(1), RPS5(1) 17258755 45 36 45 21 5 10 17 4 9 0 0.879 1.000 1.000 552 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(4), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), TBXA2R(1) 8514322 41 36 41 22 8 8 17 5 3 0 0.770 1.000 1.000 553 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 554 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 555 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(5), GPR161(4), GPR171(3), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(3), GPR75(5) 7484334 38 35 38 19 11 7 7 7 6 0 0.857 1.000 1.000 556 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1) 9523891 40 35 40 16 8 5 15 7 5 0 0.752 1.000 1.000 557 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 18987938 41 35 41 16 3 12 8 10 8 0 0.754 1.000 1.000 558 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(5), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(4) 8603698 38 35 38 12 6 11 10 6 5 0 0.430 1.000 1.000 559 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(10), MPO(8), PRDX2(2), PRDX6(1), TPO(11), TYR(8) 7343191 40 35 39 18 11 4 17 4 4 0 0.818 1.000 1.000 560 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 46 35 46 13 5 9 15 9 8 0 0.384 1.000 1.000 561 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1) 7603533 41 35 41 13 0 16 14 6 5 0 0.622 1.000 1.000 562 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(8), ASPH(11), COPS5(2), CREB1(1), EDN1(1), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(4), P4HB(1) 9165972 35 34 35 14 6 10 7 9 3 0 0.655 1.000 1.000 563 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNAR2(3), JAK1(11), STAT1(7), STAT2(6), TYK2(8) 8257040 38 34 38 16 5 11 7 6 9 0 0.673 1.000 1.000 564 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RELA(2) 6273776 36 34 35 12 5 6 15 6 4 0 0.519 1.000 1.000 565 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 566 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 567 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6) 5331209 37 33 37 19 4 10 15 4 4 0 0.874 1.000 1.000 568 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1) 8797320 34 33 34 14 3 9 10 4 8 0 0.895 1.000 1.000 569 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), EPO(2), EPOR(2), GRIN1(4), HIF1A(3), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1) 9657990 33 33 33 11 4 11 6 7 5 0 0.358 1.000 1.000 570 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 9244748 36 33 36 13 4 5 12 9 6 0 0.703 1.000 1.000 571 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(7), ITGAM(8), ITGB2(4), SELE(7), SELL(2) 7886915 37 33 37 21 4 9 7 5 12 0 0.895 1.000 1.000 572 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(10), PON2(1), PON3(6), RDH11(2), RDH12(4) 6840643 37 32 36 17 3 7 11 11 5 0 0.830 1.000 1.000 573 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), LTA(4), TGFB1(2), TGFB2(3), TGFB3(1) 10113759 34 32 33 18 5 8 7 8 6 0 0.931 1.000 1.000 574 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(19), ZAP70(2) 6869407 36 32 35 18 3 8 8 7 10 0 0.907 1.000 1.000 575 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3) 10054416 33 31 33 14 4 8 8 8 5 0 0.777 1.000 1.000 576 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(2), HDAC9(16), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), YWHAH(2) 5163667 33 31 33 11 7 5 9 9 3 0 0.516 1.000 1.000 577 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(3), GGT1(4), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(1) 9404841 33 31 33 12 8 10 7 6 2 0 0.443 1.000 1.000 578 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(11), JAK2(5), JAK3(6), STAT3(6), TYK2(8) 8386337 36 31 36 13 5 6 10 9 6 0 0.572 1.000 1.000 579 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 32 30 32 15 10 3 8 5 5 1 0.837 1.000 1.000 580 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 32 30 32 15 10 3 8 5 5 1 0.837 1.000 1.000 581 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(10), GBA(3), MPO(8), PRDX6(1), TPO(11) 6371299 33 29 32 16 11 5 12 2 3 0 0.804 1.000 1.000 582 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 7 ACE(8), AGT(4), AGTR2(2), BDKRB2(3), KNG1(5), NOS3(4), REN(3) 6950425 29 28 29 16 5 7 9 3 5 0 0.839 1.000 1.000 583 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7) 6487339 30 28 30 11 6 6 8 9 1 0 0.632 1.000 1.000 584 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(7), ACO2(3), ACSS1(5), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(1) 10104755 32 28 32 16 3 10 11 2 6 0 0.865 1.000 1.000 585 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(2), FH(3), IDH2(1), MDH1(1), OGDH(11), SDHA(7), SUCLA2(1) 7148129 29 27 28 10 5 4 11 5 4 0 0.657 1.000 1.000 586 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), TOB2(3) 7155105 27 26 27 11 2 5 8 8 4 0 0.851 1.000 1.000 587 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4) 10028443 28 25 28 12 9 8 3 4 4 0 0.564 1.000 1.000 588 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CCND1(4), CDK4(5), CDKN1B(3), CFL1(2), E2F2(3), MDM2(2), PRB1(8) 5364510 27 25 27 11 1 7 10 5 4 0 0.804 1.000 1.000 589 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3) 6074660 25 24 25 11 4 2 9 6 4 0 0.853 1.000 1.000 590 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3) 6074660 25 24 25 11 4 2 9 6 4 0 0.853 1.000 1.000 591 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4), VKORC1(2) 8415959 27 24 27 10 10 8 3 2 4 0 0.361 1.000 1.000 592 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6) 7528437 26 24 26 13 5 6 7 4 4 0 0.819 1.000 1.000 593 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 9007518 30 24 30 11 0 11 10 5 4 0 0.716 1.000 1.000 594 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(2), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1) 10918791 26 24 26 16 6 8 5 2 5 0 0.893 1.000 1.000 595 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(3), FARS2(4), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7) 6306436 29 24 29 11 0 9 11 3 6 0 0.603 1.000 1.000 596 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 10 CDK5(3), CDK5R1(1), EGR1(4), KLK2(2), MAP2K1(5), MAP2K2(6), NGFR(2), RAF1(3) 5378267 26 23 26 12 8 4 8 2 4 0 0.597 1.000 1.000 597 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 8 CD3D(1), GZMB(2), ICAM1(6), ITGAL(7), ITGB2(4), PRF1(4) 5900376 24 23 24 12 5 5 4 2 8 0 0.649 1.000 1.000 598 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), DHFR(3), FPGS(2), GGH(3) 4978860 25 23 25 11 3 2 13 3 4 0 0.769 1.000 1.000 599 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3) 7706334 25 22 25 14 4 6 8 1 6 0 0.893 1.000 1.000 600 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(4) 5101404 22 22 22 10 5 4 9 3 1 0 0.655 1.000 1.000 601 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1) 5385256 23 22 23 19 2 8 5 6 2 0 0.994 1.000 1.000 602 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(13), GLS(1), GLUD1(4), GOT1(1) 5928982 22 22 22 10 4 5 5 5 3 0 0.801 1.000 1.000 603 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 5250461 24 21 24 17 7 3 7 2 4 1 0.960 1.000 1.000 604 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), WASF1(3), WASL(2) 5844308 21 21 21 15 5 5 5 4 2 0 0.990 1.000 1.000 605 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(2), TGFB2(3), TGFB3(1) 6285319 23 20 23 12 6 2 8 5 2 0 0.882 1.000 1.000 606 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), NAT1(2), XDH(6) 6066385 23 20 23 13 3 5 9 4 2 0 0.906 1.000 1.000 607 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(5), CPO(4), FECH(1), HBA2(2), UROD(1), UROS(4) 5939473 19 19 19 11 2 3 7 6 1 0 0.947 1.000 1.000 608 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), IL9(2) 4619492 18 18 18 10 4 3 6 3 2 0 0.888 1.000 1.000 609 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 12617181 18 17 18 10 0 4 5 5 4 0 0.957 1.000 1.000 610 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(6), BIRC3(2), FADD(4), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 5518937 20 17 20 10 5 5 6 3 1 0 0.735 1.000 1.000 611 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4) 6712693 19 16 19 10 3 6 5 2 3 0 0.957 1.000 1.000 612 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4) 2979765 16 16 16 7 1 6 4 5 0 0 0.692 1.000 1.000 613 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4) 6833447 17 16 17 11 3 2 4 4 4 0 0.969 1.000 1.000 614 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4) 3644574 16 15 16 7 3 3 7 3 0 0 0.695 1.000 1.000 615 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(6), SUCLA2(1) 1601806 7 7 7 4 0 2 4 1 0 0 0.831 1.000 1.000 616 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 BCL2(1), CASP3(2), CFL1(2), CFLAR(2) 2059462 7 7 7 5 2 5 0 0 0 0 0.743 1.000 1.000