rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(3), CDC20(1), CDC23(2), CDC27(2), CUL1(3), CUL2(1), CUL3(6), FBXW11(1), FBXW7(2), FZR1(4), SKP2(1), SMURF2(3), TCEB1(4), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(242), WWP2(3)	26842932	302	260	195	21	11	18	29	91	151	2	3.00e-08	<1.00e-15	<6.16e-13
2	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(3), COPS5(1), EP300(11), HIF1A(3), JUN(2), NOS3(3), VHL(242)	11058426	267	242	162	16	8	11	29	76	142	1	1.05e-08	2.44e-15	7.52e-13
3	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), FLT1(9), FLT4(7), HIF1A(3), HRAS(1), KDR(5), NOS3(3), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PXN(1), SHC1(3), VHL(242)	22290046	305	256	199	23	13	22	31	89	149	1	1.33e-08	6.11e-15	1.25e-12
4	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(3), AKT3(2), GRB2(2), ILK(4), MAPK3(1), PDK1(1), PIK3CA(12), PIK3CD(1), PTEN(22), PTK2B(3), RBL2(2), SHC1(3), SOS1(6)	13295530	64	56	59	4	4	14	5	18	22	1	0.000467	6.54e-07	0.000101
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(2), TP53(18), WT1(3)	4549903	33	29	31	3	2	3	2	11	13	2	0.0671	2.28e-05	0.00280
6	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC1B(1), ARPC2(8), CDC42(1), PAK1(2), PDGFRA(7), PIK3CA(12), PIK3R1(2), RAC1(1), WASL(6)	8954221	41	40	32	2	0	9	3	17	12	0	0.00314	3.44e-05	0.00353
7	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(2), HRAS(1), NGFR(1), NTRK1(6), PIK3CA(12), PIK3CD(1), SHC1(3), SOS1(6)	10262631	41	39	37	1	2	11	5	19	4	0	0.000147	4.03e-05	0.00355
8	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(2), ATM(16), BAX(1), CDKN1A(1), CPB2(5), CSNK1A1(2), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(18)	13158403	55	49	50	3	2	6	7	16	22	2	0.00199	8.50e-05	0.00654
9	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1)	1356343	13	13	7	1	1	1	0	1	9	1	0.705	0.000295	0.0202
10	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(1), FUT1(1), GCNT2(21), ST8SIA1(2)	3802567	26	25	10	2	2	1	1	3	19	0	0.485	0.000577	0.0356
11	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), EIF2S2(2), MAP3K14(1), NFKB1(1), RELA(5), TP53(18)	6588881	30	26	25	2	2	6	2	5	12	3	0.0465	0.00111	0.0623
12	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(3), GRB2(2), ILK(4), ITGB1(4), MAPK3(1), PDK2(2), PIK3CA(12), PIK3R1(2), PTEN(22), PTK2(1), SHC1(3), SOS1(6)	12533863	64	54	59	7	3	12	4	20	24	1	0.0256	0.00123	0.0631
13	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3E(2), CD3G(2), CD4(10)	2162366	15	14	9	1	1	2	1	2	8	1	0.386	0.00212	0.101
14	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(3), GOT2(2), TAT(1), TYR(5)	3135385	13	13	13	1	1	0	3	4	5	0	0.272	0.0105	0.461
15	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(2), DNMT1(22), MTNR1B(1), PTAFR(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), TBXA2R(2)	6746905	37	36	22	4	1	3	4	8	21	0	0.319	0.0122	0.499
16	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(2), CD3G(2), CD4(10), CD8A(1), IL3(1), KITLG(2)	4130035	22	19	16	2	1	3	1	6	10	1	0.361	0.0171	0.658
17	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(6), EGF(4), EGFR(10), HGS(2), RAB5A(1), TFRC(2)	8444563	25	24	23	0	4	1	6	6	8	0	0.00377	0.0209	0.757
18	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(10), ERBB3(6), NRG1(4), UBE2D1(2)	6806238	26	26	24	3	3	2	4	9	8	0	0.140	0.0268	0.918
19	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(2), EIF2S2(2), EIF4E(1), GSK3B(3), IGF1R(1), INPPL1(2), PDK2(2), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(22), RPS6KB1(2)	12904411	54	48	49	6	2	10	2	15	24	1	0.0187	0.0297	0.954
20	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(4), GNB1(2), PPP2CA(1), PRKAA2(4), PRKAB1(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2)	9860005	33	31	30	2	3	3	2	15	10	0	0.0263	0.0310	0.954
21	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD3G(2), CD86(1), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), PIK3CA(12), PIK3R1(2), PTPN11(1)	8302598	30	29	26	3	1	9	3	8	9	0	0.0710	0.0368	0.973
22	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), CASP9(1), CHUK(1), GHR(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(5)	9326040	26	26	20	0	0	9	2	8	6	1	0.00128	0.0369	0.973
23	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(3), PDXP(1), PSAT1(1)	3151763	12	11	12	0	2	1	0	6	3	0	0.0789	0.0377	0.973
24	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(19), MAP2(4), PPP2CA(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAR2B(2), PRKCE(2)	12102647	39	37	36	3	5	2	2	17	12	1	0.0261	0.0395	0.973
25	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(5), GLS(4), GOT1(3)	5133932	17	17	17	1	0	3	1	8	5	0	0.132	0.0395	0.973
26	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(3), MPST(2)	4479216	18	18	16	2	1	0	2	6	9	0	0.390	0.0449	1.000
27	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1), IL4(1)	2419155	14	14	8	2	1	1	1	1	9	1	0.768	0.0486	1.000
28	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(10), MAP3K1(6), MAPK14(1), NCOR2(7), RARA(4), THRA(2)	11146341	34	30	32	2	2	4	7	9	12	0	0.0154	0.0567	1.000
29	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(4), TYR(5)	6283322	19	18	19	1	1	2	5	7	4	0	0.0556	0.0580	1.000
30	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(3), EIF4B(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(2), PDK2(2), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(22), RPS6KB1(2), TSC1(2), TSC2(6)	18200218	68	61	63	8	3	12	5	22	25	1	0.0127	0.0631	1.000
31	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(5), CDKN2A(3), E2F1(1), MYC(1), PIK3CA(12), PIK3R1(2), POLR1A(4), POLR1B(2), POLR1C(3), RAC1(1), RB1(2), TP53(18)	12935489	54	49	48	6	3	13	4	18	14	2	0.00846	0.0655	1.000
32	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(22), RANGAP1(1)	5391270	24	20	18	2	2	6	2	5	9	0	0.0533	0.0709	1.000
33	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(3), GRB2(2), GSK3A(2), GSK3B(3), IARS(4), INPP5D(2), PDK1(1), PIK3CA(12), PPP1R13B(3), PTEN(22), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(6), SOS2(3), TEC(6), YWHAE(1)	23615050	91	73	82	11	3	17	8	28	33	2	0.00900	0.0908	1.000
34	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(1)	1757669	6	6	6	1	1	0	2	0	3	0	0.569	0.105	1.000
35	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(5), KARS(1)	3196928	9	9	9	1	0	1	1	2	5	0	0.448	0.124	1.000
36	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(4)	3459591	11	11	11	2	1	1	1	4	3	1	0.531	0.127	1.000
37	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), CTH(1), DNMT1(22), DNMT3A(12), DNMT3B(1), MARS(2), MARS2(3)	11258234	44	39	25	3	2	2	6	9	25	0	0.133	0.134	1.000
38	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), GNA12(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAR2B(2)	6577458	19	19	19	2	2	3	3	9	2	0	0.0991	0.143	1.000
39	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(2), AASS(5), KARS(1)	4697753	12	12	12	1	0	2	1	3	6	0	0.314	0.144	1.000
40	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	778537	4	3	4	0	0	1	1	1	1	0	0.376	0.149	1.000
41	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	2637325	9	9	9	2	0	1	3	2	3	0	0.523	0.158	1.000
42	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(8), TP53(18)	5336707	42	33	32	7	2	3	5	8	22	2	0.374	0.163	1.000
43	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(3), FUT1(1), FUT6(2), GCNT2(21), ST3GAL6(1), ST8SIA1(2)	9677693	39	33	23	4	3	4	3	5	24	0	0.301	0.169	1.000
44	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), BHMT(2), CTH(1), DNMT1(22), DNMT3A(12), DNMT3B(1), MARS(2), MARS2(3), MTAP(2), TAT(1)	13471379	47	42	28	3	3	2	7	10	25	0	0.0753	0.170	1.000
45	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(6), CSK(3), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	14449478	50	43	44	4	4	5	2	24	14	1	0.0416	0.172	1.000
46	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(6), CSK(3), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	14449478	50	43	44	4	4	5	2	24	14	1	0.0416	0.172	1.000
47	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(6), EGF(4), EGFR(10), GRB2(2), MET(6), PDGFRA(7), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(1), SRC(2)	12895146	45	40	42	5	3	7	5	16	14	0	0.0416	0.173	1.000
48	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RB1(2), RELA(5), SP1(2)	12998076	38	37	32	4	2	11	2	14	8	1	0.0322	0.174	1.000
49	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(1), NFKB1(1), NOX1(6), RELA(5), XDH(6)	6455005	21	18	16	1	1	2	4	5	8	1	0.0983	0.178	1.000
50	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(7), MMP9(1), RECK(1), TIMP3(4)	4896566	15	14	12	1	2	3	1	3	6	0	0.137	0.186	1.000
51	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(5), HADHA(2)	3225085	9	9	8	0	1	3	2	1	2	0	0.0459	0.187	1.000
52	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(2), JAK1(5), JAK2(5), STAT1(4)	5533825	18	18	18	3	1	0	2	10	5	0	0.492	0.194	1.000
53	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(3), ECHS1(2), HADHA(2)	3565989	8	8	7	0	3	1	3	1	0	0	0.0479	0.198	1.000
54	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(2), CD3G(2), CD4(10), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	7370757	30	26	24	4	2	4	2	10	11	1	0.319	0.200	1.000
55	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(3), AKT3(2), BRD4(5), CBL(2), CDC42(1), CDKN2A(3), F2RL2(1), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), LNPEP(3), MAPK3(1), PARD3(5), PDK1(1), PIK3CA(12), PIK3CD(1), PIK3R1(2), PTEN(22), PTPN1(1), RAF1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(3), YWHAE(1)	37359333	108	87	97	10	7	16	13	33	37	2	0.000373	0.201	1.000
56	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(2), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(2), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(12), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAC1(1), RPS6KA1(7), RPS6KA5(1), SOS1(6)	18932386	60	57	53	7	5	12	4	28	10	1	0.0235	0.208	1.000
57	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(10), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1)	3343993	14	14	8	2	0	2	1	1	9	1	0.816	0.209	1.000
58	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ARPC1B(1), ARPC2(8), CDC42(1), RAC1(1), WASL(6)	5343040	18	18	12	2	0	3	0	8	7	0	0.207	0.217	1.000
59	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(1), PTPRC(6)	5701434	24	22	18	3	0	3	1	8	11	1	0.547	0.227	1.000
60	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(2), VNN2(1)	7846258	19	17	18	1	3	5	4	2	5	0	0.0155	0.229	1.000
61	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(4)	2902056	8	8	8	0	0	1	0	6	1	0	0.230	0.247	1.000
62	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(6), EP300(11), NCOA3(5), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RARA(4)	13385859	37	35	34	3	3	2	7	18	7	0	0.0122	0.248	1.000
63	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(6), DAXX(5), HRAS(1), PAX3(1), PML(5), RARA(4), RB1(2), SIRT1(4), SP100(1), TNFRSF1A(1), TP53(18)	12015404	48	42	46	7	6	6	7	15	12	2	0.0543	0.253	1.000
64	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(4), AOC3(1), CES1(7)	3671618	17	16	15	3	0	2	2	8	5	0	0.311	0.253	1.000
65	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), CASP9(1), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RAF1(1), RALA(2), RALBP1(1), RELA(5)	12565092	33	33	26	3	1	10	2	11	8	1	0.0371	0.267	1.000
66	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(1), CDC25C(2), MNAT1(1), SHH(1), XPO1(6)	5730976	13	13	13	1	0	1	4	7	1	0	0.133	0.280	1.000
67	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(2), NDUFA13(2)	2720684	6	6	6	0	2	1	0	2	1	0	0.182	0.320	1.000
68	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(1), POLR2A(8), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295387	24	23	24	3	6	2	2	10	4	0	0.0931	0.328	1.000
69	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2)	3825796	12	11	12	2	1	3	1	6	1	0	0.241	0.329	1.000
70	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ARPC1B(1), ARPC2(8), NCK1(1), NCKAP1(2), NTRK1(6), RAC1(1), WASF2(2), WASF3(3), WASL(6)	9986316	31	27	24	3	0	4	2	15	10	0	0.0863	0.342	1.000
71	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(2), ENO3(2), GOT1(3), GOT2(2), PAH(4), TAT(1), YARS(1)	5536066	18	16	18	3	2	1	5	4	6	0	0.292	0.343	1.000
72	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(4), OAT(1), PRODH(1)	3619832	8	8	8	0	0	1	3	3	1	0	0.124	0.345	1.000
73	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(1), DHRSX(5), PON3(4), RDH11(3)	5824116	16	15	11	1	2	0	3	4	7	0	0.276	0.353	1.000
74	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(3), ABCB4(5), ABCC1(8), ABCC3(10)	9684385	30	23	24	3	1	4	5	9	11	0	0.0841	0.357	1.000
75	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(11)	4734833	17	15	14	3	1	2	2	7	5	0	0.524	0.360	1.000
76	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(5), GCDH(3), HADHA(2), SDHB(1)	5173720	13	13	10	0	1	3	3	1	5	0	0.0336	0.362	1.000
77	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	481049	1	1	1	0	0	0	1	0	0	0	0.751	0.362	1.000
78	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(2), GLI2(4), GLI3(5), GSK3B(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SHH(1), SMO(3), SUFU(1)	10138090	32	29	29	4	5	3	2	14	8	0	0.0855	0.373	1.000
79	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(5), HADHA(2), HADHB(3)	5572378	12	12	11	0	1	4	3	2	2	0	0.0187	0.379	1.000
80	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAP2B(2)	9420366	24	24	24	3	3	1	2	12	6	0	0.250	0.380	1.000
81	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2)	4071859	11	11	11	2	1	1	0	8	1	0	0.580	0.385	1.000
82	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(1), PTK2B(3), SHC1(3), SOS1(6), SRC(2)	5690638	18	16	18	3	1	6	2	6	3	0	0.279	0.386	1.000
83	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), RDH11(3)	3085748	7	7	7	0	2	0	1	4	0	0	0.158	0.389	1.000
84	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAP3K1(6), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), RAF1(1), SOS1(6), STAT1(4), STAT5A(2), STAT5B(2)	18108538	51	49	47	6	3	10	5	26	7	0	0.0194	0.391	1.000
85	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(3), TOB1(2), TOB2(3)	7049851	20	19	20	3	1	3	4	7	5	0	0.217	0.405	1.000
86	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1)	6888798	14	14	14	1	1	2	1	5	5	0	0.163	0.426	1.000
87	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), IDS(2), IDUA(1), LCT(2), NAGLU(2)	9307263	26	22	24	3	4	3	4	10	5	0	0.0663	0.427	1.000
88	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PRF1(1)	5356831	14	12	14	1	1	4	2	4	3	0	0.0917	0.428	1.000
89	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), LUM(1)	2353850	7	7	7	2	0	1	0	4	2	0	0.683	0.437	1.000
90	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(4), EGFR(10), GRB2(2), HRAS(1), MAPK3(1), PTPRB(3), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SPRY1(1), SPRY2(2), SPRY4(10), SRC(2)	16509407	51	41	42	5	5	12	6	11	17	0	0.0221	0.437	1.000
91	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(6), POLG(4), PRPS2(3), RRM1(3)	8012839	20	19	18	2	2	4	1	6	7	0	0.142	0.460	1.000
92	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(4), AKT1(2), AKT2(3), AKT3(2), APAF1(2), ATM(16), BAX(1), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CAPN2(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(1), DFFB(1), FAS(1), FASLG(1), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(3), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), NTRK1(6), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), RIPK1(1), TNFRSF10C(1), TNFRSF1A(1), TNFSF10(6), TP53(18), TRADD(2), TRAF2(1)	54726124	156	122	142	19	11	23	19	60	40	3	0.000254	0.466	1.000
93	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG7(4), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), PIK3C3(2), PIK3R4(4), PRKAA2(4), ULK1(1), ULK2(1), ULK3(3)	13894331	33	31	30	3	2	3	2	16	10	0	0.0740	0.480	1.000
94	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(2), CAMKK2(2), SYT1(1)	7576560	16	16	15	0	1	1	2	7	5	0	0.0480	0.486	1.000
95	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(5), GNAS(4), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295712	24	24	24	4	3	2	0	14	5	0	0.435	0.493	1.000
96	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(3), GPRC5A(1), GPRC5B(2), GPRC5C(1), GRM1(5), GRM2(2), GRM3(3), GRM4(3), GRM5(8), GRM7(4), GRM8(3)	12621622	40	34	37	5	5	6	3	15	11	0	0.0742	0.498	1.000
97	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), GRB2(2), HRAS(1), MAPK3(1), MAPK7(1), MEF2A(1), MEF2D(1), NTRK1(6), PIK3CA(12), PIK3R1(2), PLCG1(2), RPS6KA1(7), SHC1(3)	12412009	41	38	32	5	4	8	3	14	11	1	0.0730	0.499	1.000
98	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	1107719	2	2	2	1	0	1	0	1	0	0	0.763	0.515	1.000
99	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(3), AKT3(2), GRB2(2), GSK3A(2), GSK3B(3), IL4R(2), IRS1(4), JAK1(5), JAK3(3), MAP4K1(2), MAPK3(1), PDK1(1), PIK3CA(12), PIK3CD(1), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(6), SOS2(3), STAT6(4)	22819697	67	58	62	9	6	14	10	25	12	0	0.00730	0.518	1.000
100	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IKBKB(1), IL4(1), JUN(2), MAP3K1(6), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(5), TNFRSF9(1), TNFSF9(1), TRAF2(1)	13014003	31	27	28	3	0	4	1	15	10	1	0.203	0.521	1.000
101	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	1021533	2	2	2	1	0	0	0	2	0	0	0.880	0.521	1.000
102	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(2), IFNB1(3), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(3), JUN(2), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFB2(2), TGFB3(1), TRAF6(2)	19456804	45	42	41	4	4	12	0	16	12	1	0.0165	0.523	1.000
103	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(3), UXS1(1)	2648399	5	5	5	1	0	1	2	2	0	0	0.555	0.524	1.000
104	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(1), LEP(1), LEPR(1), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4)	9711466	21	21	18	2	1	4	4	3	9	0	0.0613	0.530	1.000
105	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	6954807	21	18	21	3	2	4	2	9	4	0	0.194	0.531	1.000
106	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(2), FSHR(2), GNAS(4), XPO1(6)	6080934	17	17	17	3	3	1	3	7	3	0	0.416	0.532	1.000
107	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(5), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	10437781	23	23	23	2	3	0	0	13	7	0	0.0853	0.534	1.000
108	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(2), NFATC2(5), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	7255388	28	27	26	5	5	0	1	15	7	0	0.268	0.534	1.000
109	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(10), HLA-DRA(1), HLA-DRB1(1), IFNA1(2), IFNB1(3), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1)	8368491	24	23	18	3	0	6	1	7	9	1	0.267	0.544	1.000
110	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(3), UGP2(1), UXS1(1)	3354142	6	6	6	1	0	1	3	2	0	0	0.434	0.559	1.000
111	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(16), ATR(7), CDC25C(2), CHEK2(1), TP53(18)	10758508	44	39	42	7	2	5	5	14	16	2	0.255	0.564	1.000
112	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	3581936	15	15	12	4	0	1	3	4	7	0	0.596	0.579	1.000
113	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(2), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(4)	7662500	20	19	20	3	1	3	4	7	5	0	0.240	0.580	1.000
114	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), IDH1(2), IDH2(5), MDH1(1), SDHB(1), SUCLA2(1)	5926418	14	13	11	2	1	2	1	5	5	0	0.368	0.582	1.000
115	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(5)	8256148	19	18	16	2	0	4	1	6	7	1	0.183	0.590	1.000
116	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(6), IRS1(4), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SLC2A4(1), SOS1(6), SRF(1)	16234316	48	44	43	7	5	14	5	17	7	0	0.0299	0.595	1.000
117	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(4), EGFR(10), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(5), JUN(2), MAP3K1(6), MAPK3(1), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1), STAT1(4), STAT3(3), STAT5A(2)	24617467	74	66	67	10	6	14	7	26	21	0	0.0329	0.603	1.000
118	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(6), NT5M(2), QPRT(1)	9614289	22	22	22	3	1	2	3	12	4	0	0.165	0.614	1.000
119	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(3), TPI1(1)	2534776	6	6	6	4	0	0	1	1	4	0	0.993	0.617	1.000
120	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(2)	2908836	6	6	6	1	0	0	0	4	2	0	0.766	0.617	1.000
121	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2)	3778160	8	8	7	2	1	0	0	5	2	0	0.801	0.621	1.000
122	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(3), NPPA(1), PIK3CA(12), PIK3R1(2), RELA(5), SYT1(1)	11513017	36	35	30	5	1	11	3	13	7	1	0.117	0.622	1.000
123	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(2), RAB3A(1), RAB4A(1), RAB5A(1)	2793408	5	5	5	0	1	0	1	1	2	0	0.222	0.627	1.000
124	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(3), MST1R(4)	3807978	9	9	8	2	0	1	5	1	2	0	0.562	0.630	1.000
125	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(2), IFNB1(3), JAK1(5), STAT1(4), STAT2(6), TYK2(6)	7056471	28	24	27	6	2	7	3	7	9	0	0.255	0.643	1.000
126	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	1497521	3	3	3	1	0	0	1	0	2	0	0.902	0.644	1.000
127	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), KITLG(2), TGFB2(2), TGFB3(1)	5477520	13	13	13	2	0	1	1	7	4	0	0.515	0.647	1.000
128	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), MECR(1)	5555699	10	9	10	0	1	2	4	3	0	0	0.0351	0.649	1.000
129	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(1), BMPR2(5)	4067154	9	7	9	0	0	1	2	4	2	0	0.0715	0.659	1.000
130	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(3), GPI(3), HK1(4), PFKL(1), PGAM1(1), PGK1(3), TPI1(1)	5888375	19	17	17	4	3	2	2	5	7	0	0.437	0.662	1.000
131	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(8), CCNE1(2), CCNE2(2), CDK2(2), CDK4(6), CDKN2A(3), E2F1(1), PRB1(8)	5784289	32	24	20	6	1	2	3	5	21	0	0.678	0.680	1.000
132	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), HLA-DRB1(1), IL3(1)	1780309	3	3	3	0	0	0	0	1	2	0	0.826	0.686	1.000
133	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1)	2183565	4	4	4	1	0	0	0	2	2	0	0.892	0.696	1.000
134	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2)	8183213	18	17	18	3	4	1	1	8	4	0	0.340	0.704	1.000
135	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), NAGLU(2), SPAM1(6)	13332496	40	33	38	6	6	6	5	16	7	0	0.0439	0.707	1.000
136	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK1G(3), CAMK4(1), CREBBP(6), CSNK1A1(2), ELSPBP1(1), F2(3), FGF2(1), GATA4(2), GSK3B(3), HRAS(1), MAPK14(1), MAPK3(1), MYH2(9), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(12), PIK3R1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAF1(1), RPS6KB1(2), SYT1(1)	32539613	90	76	82	9	7	13	7	32	31	0	0.00122	0.709	1.000
137	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(3), AKT3(2), BRAF(2), EIF4B(3), FIGF(2), HIF1A(3), MAPK3(1), PGF(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRKAA2(4), RHEB(4), RICTOR(4), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(1), TSC1(2), TSC2(6), ULK1(1), ULK2(1), ULK3(3), VEGFC(2)	34531290	86	78	71	8	7	14	9	31	23	2	0.000801	0.712	1.000
138	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(10), CD8A(1), IL3(1), IL4(1)	3900358	13	13	7	3	0	2	1	2	7	1	0.887	0.733	1.000
139	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(3), PPP1R1B(1)	2312513	5	5	5	2	1	1	0	3	0	0	0.748	0.734	1.000
140	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	21095269	41	39	38	3	5	10	3	18	5	0	0.00124	0.740	1.000
141	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(16), BAX(1), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), PCNA(3), RB1(2), TIMP3(4), TP53(18)	12080368	58	39	50	9	3	6	7	12	28	2	0.209	0.751	1.000
142	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SCLY(2), SEPHS1(1)	7909012	17	17	17	3	2	0	6	5	4	0	0.284	0.755	1.000
143	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	2545277	3	3	3	1	0	0	2	0	1	0	0.770	0.757	1.000
144	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1070228	1	1	1	0	0	0	0	1	0	0	0.838	0.763	1.000
145	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(5), JAK2(5), PTPRU(5), STAT1(4)	7501440	21	19	21	4	2	0	2	13	4	0	0.473	0.765	1.000
146	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), GNB1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2)	6151940	19	18	19	4	2	2	0	12	3	0	0.546	0.767	1.000
147	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(3), C1S(16), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1)	11483685	38	31	25	6	3	5	1	17	12	0	0.167	0.767	1.000
148	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1)	6720053	14	12	14	2	0	3	2	5	4	0	0.266	0.768	1.000
149	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), NDST1(2), NDST2(3), NDST4(5)	13199599	33	31	27	3	2	4	5	9	13	0	0.0392	0.770	1.000
150	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(5), TNFRSF13B(1), TNFRSF17(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	9546530	18	17	15	2	0	4	0	7	6	1	0.363	0.773	1.000
151	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), STX1A(1), VAMP2(1)	2113258	5	5	5	3	0	0	0	2	3	0	0.972	0.775	1.000
152	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(2), GBA3(2), MPO(4), TPO(4)	5410392	14	13	14	3	1	2	4	5	2	0	0.390	0.776	1.000
153	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(1), FUT6(2), ST3GAL3(3)	2932945	7	7	6	2	2	1	0	0	4	0	0.785	0.782	1.000
154	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(2), IFNB1(3), NFKB1(1), RELA(5), TRAF6(2)	7067516	14	14	11	2	1	6	0	1	5	1	0.361	0.785	1.000
155	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD2(1), GGT1(2)	3696433	5	5	5	1	0	1	2	1	1	0	0.469	0.785	1.000
156	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(2)	3173931	4	4	4	0	1	0	1	0	2	0	0.468	0.791	1.000
157	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1344260	3	3	3	2	0	2	0	1	0	0	0.868	0.791	1.000
158	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2)	8545476	21	20	19	3	1	4	4	4	8	0	0.173	0.798	1.000
159	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	9718536	24	23	24	4	2	2	1	12	7	0	0.408	0.806	1.000
160	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2)	10831774	20	19	16	1	1	1	3	7	8	0	0.150	0.815	1.000
161	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1)	5329177	7	7	7	1	1	1	3	2	0	0	0.321	0.822	1.000
162	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(5), JUN(2), MAP3K1(6), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1), STAT1(4), STAT3(3), STAT5A(2)	22937485	67	62	62	10	4	13	5	27	18	0	0.0574	0.824	1.000
163	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(5), ACADM(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), CNDP1(4), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(2)	17467757	47	41	44	7	3	6	12	13	13	0	0.0355	0.829	1.000
164	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CD28(1), CD4(10), CXCR4(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1)	13175511	28	27	22	3	4	2	2	10	9	1	0.175	0.830	1.000
165	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(6), FADS2(2), FASN(3), HADHA(2), PECR(1)	9051181	18	17	15	3	3	2	4	5	4	0	0.169	0.830	1.000
166	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC2(4), AOC3(1), CES1(7), DDHD1(2), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PLA1A(3), PNPLA3(2), SH3GLB1(2)	16430976	37	32	35	3	2	3	4	17	11	0	0.0365	0.831	1.000
167	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), DPM2(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(6), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(3), SOS1(6)	10114817	40	37	35	8	1	11	4	17	7	0	0.254	0.847	1.000
168	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2)	2037938	2	2	2	0	0	1	0	1	0	0	0.551	0.848	1.000
169	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(7), RPE(1), UCHL3(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	11577235	27	23	25	4	2	5	4	6	10	0	0.192	0.849	1.000
170	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), FDPS(1), IDI1(1), LSS(2), MVK(1), PMVK(1), SC5DL(1), VKORC1(1)	7266876	12	12	12	1	0	0	1	8	3	0	0.408	0.850	1.000
171	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(3), GPR75(1)	6370681	10	10	10	2	1	2	0	4	2	1	0.190	0.852	1.000
172	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(4), EIF2B5(2), EIF2S2(2), EIF5(2), GSK3B(3)	7634764	16	15	14	2	1	1	2	4	8	0	0.359	0.853	1.000
173	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(3), CASP8(1), CASP9(1), JUN(2), PRF1(1)	8351688	17	16	17	3	0	3	1	8	5	0	0.446	0.853	1.000
174	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(2), BAX(1), CSF2RB(1), IGF1R(1), IL3(1), KIT(3), KITLG(2), PIK3CA(12), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	14196205	38	38	35	7	5	7	3	19	4	0	0.104	0.859	1.000
175	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(2), IL4(1), IL4R(2), IRS1(4), JAK1(5), JAK3(3), RPS6KB1(2), SHC1(3), STAT6(4)	9209886	28	26	28	5	4	3	4	10	7	0	0.248	0.859	1.000
176	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1)	8767774	18	18	18	3	0	1	2	8	7	0	0.536	0.865	1.000
177	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(5), BTK(1), CDC42(1), CFL1(1), GDI2(1), INPPL1(2), ITPR1(4), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(12), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(2), PPP1R13B(3), PTEN(22), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(4), WASL(6)	46030110	124	97	118	15	6	27	12	39	39	1	0.000299	0.868	1.000
178	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(5), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP2K6(1), MAP3K1(6), MAP3K5(5), MAP3K7(1), MAP3K9(4), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(1), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), RPS6KA5(1), SHC1(3), STAT1(4), TGFB2(2), TGFB3(1), TRADD(2), TRAF2(1)	24138594	60	52	58	7	6	5	3	31	15	0	0.0268	0.874	1.000
179	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(1), AKR1B10(3), ALAS1(5), ALAS2(3), AOC2(4), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(5), GATM(2), GLDC(3), GNMT(2), MAOA(1), PHGDH(3), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(4), SARS(3), SHMT1(2), SHMT2(3), TARS(6), TARS2(5)	27800539	78	67	74	11	10	12	13	27	16	0	0.00377	0.880	1.000
180	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(1), NEK1(3), WEE1(1)	4906037	7	6	7	1	0	2	0	3	2	0	0.447	0.880	1.000
181	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDFT1(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1)	8670732	16	14	16	1	0	2	1	8	5	0	0.213	0.882	1.000
182	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(7), AXIN1(3), CTNNB1(1), DVL1(1), FZD1(2), GNAI1(1), GSK3B(3), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(5), TLR4(2)	19541154	49	49	41	7	2	12	6	16	12	1	0.0233	0.883	1.000
183	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(3), C1S(16), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1), MASP1(2), MASP2(1), MBL2(1)	14029008	42	35	29	7	5	6	1	18	12	0	0.126	0.888	1.000
184	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(16), ATR(7), BRCA1(7), CDC25A(1), CDC25B(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(11), MYT1(2), PRKDC(11), RPS6KA1(7), TP53(18), WEE1(1)	28513136	86	67	77	11	3	10	10	34	26	3	0.0202	0.890	1.000
185	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(5), F13A1(1), F2(3), FGA(2), FGG(5), PLAT(4), PLAU(4), PLG(5)	8931892	29	27	24	6	1	1	4	13	10	0	0.413	0.895	1.000
186	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(11), LPL(2), NCOA1(3), NCOA2(9), PPARG(2)	12108595	33	24	24	4	3	3	4	9	14	0	0.0681	0.896	1.000
187	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(5), C6(1), C7(3), C8A(1)	8544986	16	16	16	3	2	2	1	8	3	0	0.325	0.897	1.000
188	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9596586	18	17	14	1	1	2	2	5	8	0	0.213	0.899	1.000
189	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(1), CDC25C(2), CSK(3), GRB2(2), PRKCA(2), PTPRA(3), SRC(2)	6030235	16	14	16	4	0	6	1	6	3	0	0.418	0.899	1.000
190	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	1350624	1	1	1	1	0	0	0	1	0	0	0.940	0.901	1.000
191	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CFL1(1), CHN1(2), LIMK1(4), MAP3K1(6), MYL2(1), MYLK(4), NCF2(1), PAK1(2), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLD1(3), PPP1R12B(1), RAC1(1), RALBP1(1), RPS6KB1(2), TRIO(2), VAV1(3)	23141692	56	51	51	6	1	8	4	24	19	0	0.0308	0.907	1.000
192	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(3), PPP2CA(1)	6119567	11	10	9	0	0	1	1	1	8	0	0.108	0.908	1.000
193	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(2), MEF2A(1), MEF2D(1)	5358220	8	8	7	1	1	0	0	2	5	0	0.614	0.909	1.000
194	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3CA(12), PIK3R1(2), PLCG1(2), RAF1(1), SHC1(3), SOS1(6)	12245002	37	35	33	7	3	10	3	16	5	0	0.212	0.911	1.000
195	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(6), DFFB(1), PRF1(1)	6823412	10	9	10	0	2	2	2	3	1	0	0.0518	0.912	1.000
196	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS1(1)	2028703	2	2	2	1	0	0	0	2	0	0	0.869	0.912	1.000
197	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), NFS1(2), THTPA(1), TPK1(1)	4262104	6	6	6	2	2	0	1	3	0	0	0.691	0.913	1.000
198	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(5), ATM(16), ATR(7), CCNA1(8), CCNE1(2), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), E2F1(1), GSK3B(3), HDAC1(2), RB1(2), SKP2(1), TGFB2(2), TGFB3(1), TP53(18)	19775709	81	63	71	14	4	11	8	22	34	2	0.127	0.917	1.000
199	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(3), C1S(16), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1), C8B(2), MASP1(2)	13681391	42	35	29	7	6	5	1	18	12	0	0.135	0.917	1.000
200	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(3), CPOX(6), FECH(2), PPOX(1), UROD(1)	5062066	18	18	13	6	0	0	3	7	8	0	0.870	0.918	1.000
201	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(3), JAK1(5), PTPRU(5), STAT1(4), STAT2(6), TYK2(6)	8016205	31	27	30	7	3	5	3	11	9	0	0.320	0.918	1.000
202	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(2), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), YOD1(1)	16967600	35	31	28	3	2	4	6	8	15	0	0.0748	0.922	1.000
203	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(7), AXIN1(3), BTRC(2), CREBBP(6), CSNK1A1(2), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(4)	18971371	42	37	36	4	3	3	5	17	14	0	0.0218	0.923	1.000
204	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(2), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(4)	7542016	19	18	19	4	1	3	3	7	5	0	0.440	0.927	1.000
205	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), ITGB1(4), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(2), PIK3CA(12), PIK3R1(2), PTK2B(3), PTPN6(3), RAC1(1), SYK(1), VAV1(3)	12279664	40	36	36	8	2	10	5	11	12	0	0.250	0.928	1.000
206	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(8), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(2), SKP2(1)	5788222	19	18	16	5	1	3	2	3	10	0	0.576	0.929	1.000
207	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(1), PER1(5)	5502413	9	9	8	2	0	0	2	3	3	1	0.634	0.929	1.000
208	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), MAP3K14(1), NFKB1(1), RELA(5), TRAF3(1), TRAF6(2)	12025983	20	18	17	2	0	5	0	4	10	1	0.246	0.930	1.000
209	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(5), ACO1(4), ACSS1(3), ACSS2(7), IDH1(2), IDH2(5), MDH1(1), SUCLA2(1)	8812773	28	23	24	5	1	5	3	8	10	1	0.361	0.932	1.000
210	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(1), TOP2A(4), TOP2B(2)	6729138	8	8	8	0	2	1	0	3	2	0	0.206	0.933	1.000
211	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1)	15491738	36	33	33	4	1	5	3	16	11	0	0.0747	0.933	1.000
212	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(1), ST3GAL3(3), ST3GAL4(1)	4537861	11	10	10	4	2	0	1	1	7	0	0.895	0.934	1.000
213	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	5178481	9	9	9	3	0	3	3	2	1	0	0.572	0.935	1.000
214	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	5547482	12	12	12	3	0	1	1	5	5	0	0.807	0.936	1.000
215	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(2), SLC18A3(1)	4258777	10	10	8	3	0	2	0	2	6	0	0.887	0.938	1.000
216	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), CHRNB1(2), MUSK(1), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(3), SRC(2), TERT(5)	10697791	30	28	27	6	2	13	2	9	4	0	0.154	0.941	1.000
217	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(2)	2542945	4	4	4	2	0	0	2	1	1	0	0.861	0.941	1.000
218	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2A(1), MEF2D(1), PPP3CA(2), PPP3CC(3), SLC2A4(1), SYT1(1)	13416740	20	20	19	1	2	1	1	7	9	0	0.0864	0.942	1.000
219	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(10), HRAS(1), KLK2(1), MAPK3(1), NGFR(1), RAF1(1)	5216259	16	16	9	4	2	1	0	5	8	0	0.813	0.956	1.000
220	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), DHCR7(2), FDFT1(2), FDPS(1), GGCX(1), IDI1(1), IDI2(2), LSS(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1), VKORC1(1)	12617987	23	21	21	2	0	2	1	11	9	0	0.266	0.957	1.000
221	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(2), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(2), PPP3CC(3), SYNJ1(5), SYNJ2(6), SYT1(1)	14557266	31	31	29	5	1	6	1	16	7	0	0.208	0.957	1.000
222	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), LCMT2(3), PCYT1A(1), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9072873	16	15	16	2	1	2	1	7	5	0	0.438	0.959	1.000
223	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	2272771	1	1	1	1	0	0	0	0	1	0	0.967	0.959	1.000
224	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), NDUFA1(1), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1)	4300772	7	6	7	2	1	2	1	3	0	0	0.532	0.960	1.000
225	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3CA(12), PIK3R1(2), RAC1(1), RAF1(1), RB1(2), RELA(5)	13308701	42	36	33	7	2	10	4	12	13	1	0.189	0.960	1.000
226	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADS(3), ACSL1(2), ACSL3(13), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(5), HADHA(2), PECR(1), SCP2(2)	11117341	32	28	20	7	2	5	6	14	5	0	0.200	0.962	1.000
227	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(2), AASS(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(4), GCDH(3), HADHA(2), PLOD1(3), PLOD2(4), PLOD3(11), SHMT1(2), SHMT2(3), TMLHE(1)	23315967	68	55	56	12	4	10	6	18	29	1	0.240	0.964	1.000
228	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(4)	4078790	10	10	10	3	1	0	4	2	3	0	0.657	0.964	1.000
229	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), PPARG(2), RETN(1)	3623001	5	5	5	2	1	2	0	1	1	0	0.732	0.965	1.000
230	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(2), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RPS6KA1(7), SRC(2)	13011651	35	33	31	6	5	3	0	19	7	1	0.292	0.966	1.000
231	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(2), TPH1(1)	3765718	5	5	5	2	1	1	1	1	1	0	0.762	0.969	1.000
232	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(10), PDK2(2), PIK3CA(12), PIK3R1(2), PRKCA(2), PTEN(22), RPS6KB1(2)	18319467	75	66	72	15	7	16	6	24	21	1	0.116	0.970	1.000
233	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), CLTB(1), COPA(6), GBF1(7), GPLD1(1), KDELR2(2), KDELR3(2)	10825705	26	25	26	5	1	1	4	12	7	1	0.458	0.970	1.000
234	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(7), FYN(2), LRP8(4), RELN(5), VLDLR(2)	9287001	20	19	15	3	1	4	0	5	10	0	0.612	0.970	1.000
235	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2)	5551696	11	11	9	3	0	2	0	3	6	0	0.823	0.971	1.000
236	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(5), JAK2(5), TYK2(6)	6769437	19	19	18	5	1	0	3	7	8	0	0.803	0.972	1.000
237	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(5), JAK2(5), TYK2(6)	6769437	19	19	18	5	1	0	3	7	8	0	0.803	0.972	1.000
238	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), DDC(2), EPX(2), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TAT(1), TPO(4)	14132890	39	33	36	6	3	4	9	11	12	0	0.127	0.974	1.000
239	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(1), PDE1B(5), PLCB1(1), PLCB2(2), TRH(8)	7190204	20	18	13	9	3	2	0	4	11	0	0.982	0.975	1.000
240	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(2), CD3G(2), CD4(10), IL12RB1(2), IL12RB2(2), JAK2(5), STAT4(1), TYK2(6)	9673965	32	29	25	6	2	2	3	10	14	1	0.661	0.976	1.000
241	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), CHST12(2), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(4)	5671732	14	14	14	4	2	1	4	2	5	0	0.709	0.976	1.000
242	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(7), EIF4E(1), FBL(1), GPT(2), LDHB(1), LDHC(3), MAPK14(1), NCL(4)	5863439	20	18	19	6	0	0	5	8	7	0	0.854	0.977	1.000
243	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2)	16469964	31	27	26	4	2	2	3	13	11	0	0.313	0.977	1.000
244	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(2), ATM(16), ATR(7), BAI1(1), BAX(1), BBC3(1), BID(1), CASP8(1), CASP9(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNG2(1), CD82(3), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), PTEN(22), RCHY1(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(11), TP53(18), TP53I3(6), TP73(3), TSC2(6)	42330430	144	102	135	23	9	20	16	37	59	3	0.0173	0.978	1.000
245	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1)	6394068	13	13	13	4	0	6	1	6	0	0	0.445	0.978	1.000
246	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(4), MAPK10(1), MAPK7(1), MAPK9(2), NFATC3(5), NR2C2(1), PAPPA(1), SHC1(3), TP53(18), TRAF6(2), ZAK(3)	32617384	90	75	84	14	7	10	12	34	25	2	0.0325	0.978	1.000
247	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(2), CASP9(1), DAXX(5), FAS(1), FASLG(1), HSPB2(2), MAPKAPK2(1)	7180948	13	13	13	3	2	1	1	7	2	0	0.502	0.978	1.000
248	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(2), LTA4H(4), PLA2G6(3), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(4), TBXAS1(3)	9760650	27	24	24	6	2	4	6	7	7	1	0.355	0.979	1.000
249	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(2), FTCD(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	12548008	22	21	22	4	3	4	0	10	5	0	0.301	0.979	1.000
250	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(4), AOC3(1), CNDP1(4), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(2)	18839524	48	42	45	9	3	6	13	14	12	0	0.0912	0.979	1.000
251	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(1), AGTR1(2), BDKRB2(1), KNG1(2), NOS3(3), REN(1)	6220091	15	14	13	4	1	3	2	4	5	0	0.599	0.979	1.000
252	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), ASPA(1), CNDP1(4), DDC(2), HAL(1), HARS(1), HNMT(1), MAOA(1), PRPS1(1), PRPS2(3)	15828919	40	37	37	7	2	7	7	14	10	0	0.119	0.979	1.000
253	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(2), CAPN2(2), EGF(4), EGFR(10), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTK2(1), PXN(1), TLN1(7)	21454073	54	48	51	9	8	4	4	22	16	0	0.163	0.979	1.000
254	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2C1(5), MANBA(1), NEU1(1)	10318615	19	18	19	4	2	3	2	10	2	0	0.366	0.979	1.000
255	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(2)	4682284	6	6	6	2	0	0	0	5	1	0	0.802	0.980	1.000
256	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(3), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(4), ITPR2(10), ITPR3(4), PDK1(1), PHF11(1), PIK3CA(12), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTEN(22), PTPRC(6), RPS6KA1(7), RPS6KB1(2), SAG(4), SYK(1), TEC(6), VAV1(3)	36400706	112	96	105	19	7	21	11	36	35	2	0.0136	0.980	1.000
257	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(2), RB1(2)	5632778	12	11	12	5	1	2	1	2	6	0	0.880	0.981	1.000
258	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), NEDD8(2), RB1(2), SKP2(1)	5746773	13	12	12	4	1	2	1	2	7	0	0.779	0.981	1.000
259	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT3(2), B4GALT5(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	5027823	9	9	8	6	1	0	1	1	6	0	0.984	0.982	1.000
260	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(5), CS(2), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A11(1)	6003931	14	14	14	4	1	3	0	6	4	0	0.566	0.982	1.000
261	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), MAPK3(1), PIK3CA(12), PIK3R1(2), RAF1(1), SHC1(3), SOS1(6)	12073442	35	32	32	8	5	10	3	14	3	0	0.195	0.983	1.000
262	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), JAK1(5), STAT1(4), STAT3(3), STAT5A(2)	7906947	17	17	16	4	1	0	1	7	8	0	0.826	0.983	1.000
263	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(6), MYC(1), NFATC1(2), NFATC2(5), NFKB1(1), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), SYT1(1)	17766085	43	39	37	6	4	5	0	16	17	1	0.166	0.983	1.000
264	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(3), CREB5(2), ERBB4(7), F2RL2(1), GAB1(1), GRB2(2), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), MET(6), MYC(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARD3(5), PDK1(1), PIK3CA(12), PIK3CD(1), PPP1R13B(3), PREX1(6), PTEN(22), PTK2(1), PTPN1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(6), SOS2(3), TSC1(2), TSC2(6), YWHAE(1)	49096208	140	108	128	22	10	21	12	49	46	2	0.0185	0.984	1.000
265	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2)	11441752	29	27	28	5	4	3	4	12	6	0	0.261	0.985	1.000
266	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), FAH(1), GOT1(3), GOT2(2), HGD(2), MAOA(1), TAT(1), TH(2), TPO(4), TYR(5)	20485286	62	53	58	12	5	5	8	24	20	0	0.291	0.985	1.000
267	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LDLR(1), LPL(2)	3413036	4	4	4	2	0	3	0	1	0	0	0.732	0.986	1.000
268	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	11867713	20	19	20	4	3	4	0	8	5	0	0.359	0.986	1.000
269	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(7), AR(1), ASAH1(2), BRAF(2), EGFR(10), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(12), PIK3CD(1), PIK3R1(2), PITX2(2), RAF1(1), SRC(2)	34879153	74	57	69	9	8	17	12	27	9	1	0.000940	0.986	1.000
270	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(16), BMPR1B(1), CCND2(1), CDK4(6), EGR1(10), ESR2(2), FSHR(2), GJA4(1), MLH1(2), NCOR1(4), NRIP1(6), PGR(2), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(2)	22374800	60	52	50	8	4	7	7	17	25	0	0.0785	0.986	1.000
271	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT1(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6814216	11	11	11	3	3	2	1	5	0	0	0.388	0.987	1.000
272	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAX(1), BCL10(1), BID(1), CASP8AP2(4), CASP9(1), CES1(7)	7571865	17	17	15	5	0	1	0	7	9	0	0.887	0.988	1.000
273	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(6), GRIN2B(6), NOS1(9), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), SYT1(1)	16559708	44	39	43	9	7	8	1	22	6	0	0.166	0.988	1.000
274	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(4), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(6), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKG1(3), PRKG2(2)	20348083	43	40	40	6	5	5	3	20	10	0	0.124	0.989	1.000
275	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1)	7034714	11	11	11	3	0	3	2	3	3	0	0.614	0.989	1.000
276	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(1), PRKCA(2), RELA(5)	5442041	9	9	6	4	0	3	0	0	5	1	0.927	0.989	1.000
277	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), ITPKA(1), ITPKB(1)	3678919	4	4	4	2	1	1	0	1	1	0	0.822	0.989	1.000
278	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(3), NR1H4(2)	3365546	6	6	6	3	0	3	0	3	0	0	0.802	0.990	1.000
279	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1)	4396277	5	5	5	2	0	0	1	4	0	0	0.741	0.990	1.000
280	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(2), GHR(1), HRAS(1), IGF1R(1), PIK3CA(12), PIK3R1(2), SHC1(3)	8559038	24	23	21	6	2	7	3	9	3	0	0.356	0.990	1.000
281	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGAL(5), ITGAM(5), ITGB2(1), SELE(5)	6986089	19	19	19	5	1	6	3	4	5	0	0.400	0.990	1.000
282	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV1(1), NDUFV2(1)	4638002	12	12	12	4	0	1	1	7	3	0	0.873	0.990	1.000
283	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(3), AKT3(2), GRB2(2), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(5), JAK2(5), JAK3(3), PIK3CA(12), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(6), SOS2(3), SRC(2), STAT6(4), TYK2(6)	23899296	73	61	69	13	2	15	13	27	16	0	0.0734	0.991	1.000
284	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(3), PKM2(1), RPE(1), TKT(1), TPI1(1)	11637287	28	26	28	6	0	3	5	8	12	0	0.491	0.992	1.000
285	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(2), SULT1C4(1), SULT4A1(1)	8238711	26	26	24	6	2	1	2	10	11	0	0.742	0.992	1.000
286	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(1), CDC25B(1), CDC25C(2), MYT1(2), WEE1(1)	9173713	23	20	23	5	0	3	3	10	7	0	0.495	0.992	1.000
287	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(5), JAK2(5), JAK3(3), MAPK3(1), STAT3(3), TYK2(6)	7595297	23	23	22	9	1	0	4	9	9	0	0.953	0.992	1.000
288	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8)	10720371	25	22	23	4	2	0	0	11	12	0	0.531	0.993	1.000
289	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(7), RPE(1), UGP2(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), XYLB(1)	17938184	41	36	39	7	3	6	7	13	12	0	0.174	0.993	1.000
290	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(3), B3GNT7(1), B4GALT3(2), B4GALT4(3), CHST1(2), CHST2(1), CHST4(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	7451397	19	18	18	6	1	3	2	3	10	0	0.790	0.993	1.000
291	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(3), GOT2(2), PAH(4), TAT(1), YARS(1)	5743651	12	12	12	4	1	0	3	3	5	0	0.826	0.993	1.000
292	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELE(5)	8049451	20	19	20	5	1	5	4	5	5	0	0.436	0.994	1.000
293	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADS(3), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CPT1C(4), CPT2(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(5), GCDH(3), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PECI(1)	32352413	75	62	56	12	5	7	12	30	21	0	0.0639	0.994	1.000
294	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(1), LTA(1), MAP3K1(6), MAP3K14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TRAF2(1), TRAF3(1)	14638426	22	19	19	3	1	4	0	6	10	1	0.309	0.995	1.000
295	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(4), AOC3(1), ASPA(1), CNDP1(4), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HNMT(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(1)	25522496	56	48	53	7	3	11	8	20	14	0	0.0170	0.995	1.000
296	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(2), PRKCA(2), PTK2B(3)	4390874	8	8	7	6	0	3	0	1	4	0	0.988	0.995	1.000
297	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(16), CDC25A(1), CDC25B(1), CDC25C(2), CDK2(2), CDK4(6), MYT1(2), RB1(2), TP53(18), WEE1(1)	11800521	51	41	46	10	2	6	7	14	20	2	0.337	0.996	1.000
298	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(2), SP1(2), SP3(2)	4473590	8	8	8	3	0	2	0	2	4	0	0.894	0.996	1.000
299	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(10), IGF1R(1), MYC(1), POLR2A(8), PPP2CA(1), PRKCA(2), RB1(2), TEP1(4), TERT(5), TNKS(4), TP53(18), XRCC5(3)	18382141	61	48	57	13	8	11	7	15	18	2	0.113	0.996	1.000
300	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), DDC(2), EPX(2), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), TAT(1), TPO(4)	22080165	51	44	48	7	4	5	10	17	15	0	0.0641	0.996	1.000
301	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(1), PER1(5), PER2(4), PER3(3)	11025602	16	16	14	3	0	1	4	6	4	1	0.404	0.996	1.000
302	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(5), JAK2(5), JAK3(3), PIAS1(4), PIAS3(2), PTPRU(5), SOAT1(4)	8989340	28	24	26	6	1	2	5	11	9	0	0.401	0.996	1.000
303	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(2), IFNGR2(2), IKBKB(1), JAK2(5), NFKB1(1), RB1(2), RELA(5), TNFRSF1A(1), TP53(18), USH1C(3), WT1(3)	11741949	44	38	39	10	2	6	4	11	18	3	0.552	0.996	1.000
304	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(2), CREBBP(6), EP300(11), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1)	16947697	33	31	30	5	2	3	7	14	7	0	0.101	0.996	1.000
305	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F5(8), F7(1), FGA(2), FGG(5), PROC(4), PROS1(4), TFPI(1)	10725276	28	27	26	7	1	3	1	12	10	1	0.649	0.997	1.000
306	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(2), QPRT(1)	14178712	29	28	29	6	1	3	4	14	7	0	0.380	0.997	1.000
307	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NEU1(1)	12702405	21	19	21	4	2	3	3	11	2	0	0.276	0.997	1.000
308	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3), UROD(1)	5212363	16	16	14	5	0	1	3	9	3	0	0.698	0.997	1.000
309	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(6), DDX20(4), E2F1(1), ETS1(1), ETS2(1), FOS(1), HRAS(1), JUN(2), NCOR2(7), RBL2(2), SIN3A(1), SIN3B(1)	16981032	28	26	28	4	2	3	2	12	9	0	0.201	0.997	1.000
310	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), HADHA(2)	7977735	19	19	16	5	1	4	3	5	6	0	0.558	0.997	1.000
311	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), IKBKB(1), JUN(2), LTA(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	15660452	33	30	30	6	2	4	2	14	10	1	0.437	0.997	1.000
312	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(3), NOTCH1(5)	5218392	9	9	7	3	1	1	0	3	4	0	0.883	0.997	1.000
313	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(10), ELK1(1), GNAS(4), GNB1(2), GRB2(2), HRAS(1), IGF1R(1), ITGB1(4), KLK2(1), MAPK3(1), MKNK1(2), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(4), RAF1(1), RPS6KA1(7), RPS6KA5(1), SHC1(3), SOS1(6), SRC(2), STAT3(3)	21388019	68	56	62	14	7	11	6	26	17	1	0.264	0.998	1.000
314	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), BCKDHA(1), ECHS1(2), EHHADH(5), HADHA(2), HADHB(3), HIBADH(1), IVD(2), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	23862148	52	50	48	9	3	8	10	18	13	0	0.138	0.998	1.000
315	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(5), C6(1), C7(3), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELP(2), SELPLG(2), VCAM1(3)	16371292	35	33	35	8	4	5	5	15	6	0	0.283	0.998	1.000
316	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(6), TAF13(1), TAF1L(7), TAF2(5), TAF4(5), TAF4B(5), TAF5(2), TAF5L(2), TAF6(1), TAF7(1), TAF7L(5), TAF9B(1)	23845446	57	50	53	9	4	7	6	23	17	0	0.0784	0.998	1.000
317	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(7), CALM2(1), CAMK1(1), CAMK1G(3), IGF1R(1), INSR(6), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2D(1), NFATC1(2), NFATC2(5), PIK3CA(12), PIK3R1(2), PPP3CA(2), PPP3CC(3), SYT1(1)	22207763	53	49	45	9	4	11	5	16	17	0	0.0826	0.998	1.000
318	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(8), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(2)	10455994	29	25	23	8	1	3	3	7	15	0	0.733	0.998	1.000
319	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(3), NAT1(1), NAT2(2), XDH(6)	5170152	15	15	15	5	2	1	3	5	4	0	0.790	0.998	1.000
320	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(3), PKM2(1), RPE(1), TKT(1), TKTL1(1), TKTL2(3), TPI1(1)	13036866	30	29	30	7	0	2	5	10	13	0	0.613	0.998	1.000
321	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	5203296	10	10	8	5	0	1	1	4	4	0	0.971	0.998	1.000
322	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	5203296	10	10	8	5	0	1	1	4	4	0	0.971	0.998	1.000
323	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(1), P2RY1(1), P2RY2(1)	3573278	4	4	4	5	0	1	0	2	1	0	0.974	0.998	1.000
324	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP19(1), SRP68(2), SRP72(2), SRP9(1)	5035886	8	8	8	3	0	3	1	4	0	0	0.701	0.998	1.000
325	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SCLY(2), SEPHS1(1), SEPHS2(2)	15925758	31	30	31	5	3	2	9	10	7	0	0.182	0.998	1.000
326	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(6), EP300(11), IKBKB(1), NFKB1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF6(2)	14388684	31	27	25	5	1	5	6	6	12	1	0.238	0.999	1.000
327	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACADS(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), BCKDHA(1), DLD(2), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(2), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	28556934	58	56	54	9	4	8	12	20	14	0	0.0648	0.999	1.000
328	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(5)	6339264	12	12	12	5	0	3	0	6	3	0	0.865	0.999	1.000
329	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(6)	7505675	13	13	13	4	1	3	2	2	5	0	0.681	0.999	1.000
330	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GPX1(1), PRKCE(2)	5231754	10	10	10	5	0	0	1	7	2	0	0.955	0.999	1.000
331	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(5), ATM(16), BRCA1(7), CDKN1A(1), CHEK2(1), JUN(2), MRE11A(1), NFKB1(1), RAD50(4), RAD51(2), RELA(5), TP53(18), TP73(3)	19442110	66	56	61	12	4	10	7	22	20	3	0.198	0.999	1.000
332	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(2), CHST14(1), CHST7(1), CHSY1(9), DSE(1), XYLT1(2), XYLT2(2)	7901368	23	21	17	6	2	5	0	6	10	0	0.592	0.999	1.000
333	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), IDH2(5), MDH1(1), OGDH(3), SDHA(1), SUCLA2(1)	6227804	13	12	10	5	0	3	0	5	5	0	0.906	0.999	1.000
334	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(2)	3139352	3	3	3	3	0	1	0	1	1	0	0.980	0.999	1.000
335	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), DFFB(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(6)	11618458	24	23	24	5	1	5	3	8	7	0	0.368	0.999	1.000
336	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1)	8806978	18	18	15	5	1	1	0	9	7	0	0.862	0.999	1.000
337	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(9), FLT4(7), KDR(5), NOS3(3), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKG1(3), PRKG2(2), RYR2(11), SLC7A1(1), SYT1(1), TNNI1(1)	26966845	67	63	67	12	11	10	7	28	11	0	0.0519	0.999	1.000
338	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(2), ATM(16), BAX(1), BID(1), CASP7(1), CASP9(1), PRKCA(2), PTK2(1), PXN(1), STAT1(4), TLN1(7), TP53(18)	18131537	57	49	55	11	4	7	5	19	20	2	0.237	0.999	1.000
339	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY4(2), ADCY6(1), ADCY8(9), CACNA1A(5), CACNA1B(4), GNAS(4), GNB1(2), GNB3(2), GNG3(1), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(5), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(2), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R3(14), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(2)	36868061	95	75	84	16	14	6	8	46	21	0	0.0698	0.999	1.000
340	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(5), LCT(2), MPI(2), PYGL(1), PYGM(3), TPI1(1)	8882163	18	17	18	5	4	0	4	7	3	0	0.510	0.999	1.000
341	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(1), MAP3K1(6), MAPK3(1), NFKB1(1), NSMAF(4), RAF1(1), RELA(5), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	13355727	26	23	23	5	1	5	3	6	10	1	0.267	0.999	1.000
342	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2)	3499094	8	8	8	5	0	2	1	4	1	0	0.829	0.999	1.000
343	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), DHRSX(5), PON3(4)	11460846	26	25	21	6	1	5	2	9	9	0	0.525	0.999	1.000
344	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), HADHA(2), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), YOD1(1)	20234780	41	36	34	6	2	5	6	12	16	0	0.207	1.000	1.000
345	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(1), PSMD11(3), PSMD13(2), PSMD2(5), PSMD6(1)	10694207	25	22	24	6	1	3	3	6	12	0	0.593	1.000	1.000
346	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(7), ATF2(1), AXIN1(3), BMP10(1), BMP2(2), BMP4(1), BMP5(1), BMP7(3), BMPR2(5), CHRD(3), CTNNB1(1), DVL1(1), FZD1(2), GATA4(2), GSK3B(3), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(5), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(3)	23282567	53	46	51	8	5	6	4	24	14	0	0.0559	1.000	1.000
347	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX5(2), CBR1(2), CYP4F2(2), EPX(2), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(3), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3), TPO(4)	17956538	40	37	37	8	4	6	9	11	9	1	0.191	1.000	1.000
348	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(2), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(1), JUN(2), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK7(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(1), MEF2D(1), MKNK1(2), MKNK2(1), MYC(1), NFKB1(1), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(5), RIPK1(1), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(2), TRAF2(1)	62711428	140	99	130	18	15	14	9	55	44	3	0.00621	1.000	1.000
349	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(2), CD3G(2), ETV5(1), IL12RB1(2), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(6)	12283508	26	25	25	6	2	1	3	13	7	0	0.623	1.000	1.000
350	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3E(2), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PIK3CA(12), PIK3R1(2), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PTPN7(1), RAC1(1), RAF1(1), RASA1(3), RELA(5), SHC1(3), SOS1(6), SYT1(1), VAV1(3)	30766912	84	73	75	16	6	20	7	26	24	1	0.115	1.000	1.000
351	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	4779260	5	5	5	3	0	1	0	3	1	0	0.950	1.000	1.000
352	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), CALM2(1), EGFR(10), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), MEF2A(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(1), PTK2B(3), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SRC(2), SYT1(1)	22267611	52	42	50	10	6	12	5	18	11	0	0.190	1.000	1.000
353	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(2)	9047276	19	18	19	5	1	3	4	7	4	0	0.489	1.000	1.000
354	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(2), CALCRL(1), CD97(4), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(2), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(3), LPHN1(2), LPHN2(3), LPHN3(9), SCTR(1), VIPR1(1)	18037113	41	35	41	9	6	5	4	19	7	0	0.197	1.000	1.000
355	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(2), JAK1(5), JAK2(5), JAK3(3), PIAS3(2), PTPRU(5), SRC(2), STAT3(3)	9856128	27	24	27	9	1	3	3	11	9	0	0.850	1.000	1.000
356	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), GREB1(13), HSPB2(2), MTA1(1), MTA3(2)	6796750	20	19	17	6	0	1	2	13	4	0	0.825	1.000	1.000
357	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), GRB2(2), HRAS(1), INSR(6), IRS1(4), JAK2(5), MAPK3(1), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), PTPN6(3), RAF1(1), RPS6KA1(7), SHC1(3), SLC2A4(1), SOS1(6), SRF(1), STAT5A(2), STAT5B(2)	21326306	64	56	53	13	5	12	8	21	17	1	0.231	1.000	1.000
358	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), PC(3), PCK1(4), SDHA(1), SDHB(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	13517464	36	32	33	9	2	3	5	15	11	0	0.589	1.000	1.000
359	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(2), F2(3), GNA12(1), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(12), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2B(3), ROCK1(4)	16828076	41	40	38	9	2	9	3	18	9	0	0.255	1.000	1.000
360	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(12), PIK3R1(2), PLCB1(1), PLCG1(2), PRKCA(2), VAV1(3)	8540621	24	24	20	9	1	8	3	6	6	0	0.705	1.000	1.000
361	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(7), AXIN1(3), CREBBP(6), CTNNB1(1), DVL1(1), EP300(11), FZD1(2), GSK3B(3), HDAC1(2), LDB1(1), LEF1(1), PITX2(2), TRRAP(8)	21404191	48	42	40	7	2	3	8	19	16	0	0.107	1.000	1.000
362	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(8), CBL(2), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(6), CHUK(1), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IKBKB(1), IL4(1), ITK(2), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NCK1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(6), RASGRP1(2), SOS1(6), SOS2(3), TEC(6), VAV1(3), VAV2(4)	65780591	178	126	159	28	8	27	21	71	50	1	0.0235	1.000	1.000
363	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(2), AASS(5), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(4), GCDH(3), HADH(1), HADHA(2), HSD17B4(1), NSD1(8), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(3), PLOD2(4), PLOD3(11), RDH11(3), SETD1A(4), SETD7(1), SETDB1(6), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(4), TMLHE(1)	37046209	102	77	89	19	7	17	12	29	36	1	0.129	1.000	1.000
364	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(7), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(3), CD1E(2), CD2(2), CD22(4), CD24(1), CD33(1), CD34(2), CD38(1), CD3E(2), CD3G(2), CD4(10), CD44(2), CD55(1), CD8A(1), CR1(7), CR2(2), CSF1R(6), CSF2RA(4), CSF3R(3), DNTT(4), FLT3(6), GYPA(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL9R(2), ITGA1(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGAM(5), ITGB3(1), KIT(3), KITLG(2), MME(6), MS4A1(1), TFRC(2), TPO(4)	53253971	142	96	128	26	8	15	16	50	52	1	0.189	1.000	1.000
365	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), JUN(2), KEAP1(2), MAPK14(1), NFE2L2(7), PRKCA(2)	5598849	15	15	15	6	1	3	2	7	2	0	0.768	1.000	1.000
366	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(2), CREB5(2), DUSP4(1), DUSP9(1), EEF2K(1), EIF4E(1), GRB2(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), SHC1(3), SOS1(6), SOS2(3), TRAF3(1)	19323486	39	36	35	7	4	5	5	14	9	2	0.314	1.000	1.000
367	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(7), AXIN1(3), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), GSK3B(3), NOTCH1(5)	12978526	25	24	22	5	2	3	3	11	6	0	0.305	1.000	1.000
368	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(4), SLC18A3(1), TH(2), TPH1(1)	8959575	19	18	17	7	1	3	4	4	7	0	0.840	1.000	1.000
369	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC4(1)	4821591	9	8	9	6	2	0	2	4	1	0	0.943	1.000	1.000
370	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAX(1), BFAR(1), BTK(1), CAD(9), CASP10(3), CASP8(1), CASP8AP2(4), CSNK1A1(2), DAXX(5), DEDD(2), EGFR(10), EPHB2(2), FAIM2(1), MAP2K7(1), MAP3K1(6), MAP3K5(5), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(6), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(8), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TP53(18), TPX2(1), TRAF2(1)	47567384	116	90	106	18	11	11	10	46	35	3	0.0293	1.000	1.000
371	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), EDNRB(3), EGF(4), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(1), PLCG1(2), PRKCA(2), RELA(5)	13362042	35	31	29	8	4	4	4	11	11	1	0.531	1.000	1.000
372	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), FOS(1), IKBKB(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TLR10(2), TLR2(2), TLR4(2), TLR6(1), TLR7(4), TLR9(1), TRAF6(2)	23441123	43	39	39	7	3	8	2	15	14	1	0.185	1.000	1.000
373	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD8(1), ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), RDH11(3), SLC27A5(2), SOAT1(4), SOAT2(3)	20802444	41	37	36	8	5	3	3	17	13	0	0.351	1.000	1.000
374	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCAIP(2), UBE2E2(1)	4184639	5	5	5	3	0	3	1	0	1	0	0.829	1.000	1.000
375	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(2), ACTG2(1), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(4), FLNC(5), FSCN1(3), FSCN3(2), GDI2(1), LIMK1(4), MYH2(9), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6)	30169321	68	55	66	12	4	13	3	22	26	0	0.170	1.000	1.000
376	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PITX2(2), PLD1(3), PLD2(7), PLD3(3)	28922609	54	42	52	8	6	9	9	19	11	0	0.0164	1.000	1.000
377	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), NT5M(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2), RRM1(3), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2)	37263633	78	60	70	12	3	11	11	22	30	1	0.0503	1.000	1.000
378	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(5), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(2), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(3), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(2), TPO(4), TYR(5), TYRP1(1)	38483713	92	75	88	15	7	8	13	37	27	0	0.0846	1.000	1.000
379	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8497018	16	16	16	5	3	1	1	10	1	0	0.597	1.000	1.000
380	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), STAT1(4), STAT3(3), STAT5A(2), STAT5B(2)	19635714	54	49	49	11	4	11	5	22	12	0	0.285	1.000	1.000
381	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), SELE(5), SELP(2)	10666870	27	25	27	8	1	7	5	7	7	0	0.556	1.000	1.000
382	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), NFAT5(8), PDE6A(1), PDE6B(3), PDE6C(2), SLC6A13(2)	23627157	41	37	40	8	5	4	7	18	7	0	0.166	1.000	1.000
383	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(4), ASNS(1), ASPA(1), ASRGL1(4), ASS1(2), CAD(9), CRAT(1), DARS(1), DARS2(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), NARS2(4), PC(3), PDHA1(1), PDHA2(2), PDHB(1)	24693317	58	45	51	10	2	5	11	14	25	1	0.162	1.000	1.000
384	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	20	19	20	7	0	3	5	6	6	0	0.763	1.000	1.000
385	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	20	19	20	7	0	3	5	6	6	0	0.763	1.000	1.000
386	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	20	19	20	7	0	3	5	6	6	0	0.763	1.000	1.000
387	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(2), IL1B(1), IL6R(2), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1)	8490160	15	15	13	5	2	4	0	3	6	0	0.728	1.000	1.000
388	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(3), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(5), RENBP(2)	18875362	37	35	34	7	5	4	5	13	10	0	0.129	1.000	1.000
389	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8913722	16	16	16	5	3	1	1	10	1	0	0.595	1.000	1.000
390	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(3), NCOA2(9), NCOA3(5), NCOR2(7), POLR2A(8), RARA(4), TBP(1)	16358051	41	32	35	9	2	5	6	9	19	0	0.308	1.000	1.000
391	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1R1(1), IRAK1(3), MAP3K1(6), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(5), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(2), TRAF6(2)	15645914	28	25	25	8	1	7	2	5	12	1	0.679	1.000	1.000
392	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(2), ATF1(2), BRAF(2), CREB5(2), CREBBP(6), EGR1(10), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(8), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(6), PIK3C2G(3), PIK3CA(12), PIK3CD(1), PIK3R1(2), PTPN11(1), SHC1(3), SRC(2), TH(2)	32906311	83	69	71	17	9	18	5	28	22	1	0.141	1.000	1.000
393	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(4), ASNS(1), ASPA(1), CAD(9), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), PC(3)	16996699	36	32	32	7	1	3	9	5	17	1	0.393	1.000	1.000
394	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAX(1), BCL2A1(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DAXX(5), DFFB(1), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(6), PTPN13(8), RIPK1(1), TFG(2), TNFRSF1A(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	28439569	50	44	49	9	3	8	6	23	10	0	0.148	1.000	1.000
395	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), GPI(3), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(2), TKT(1)	12977377	26	25	24	9	1	4	4	7	10	0	0.815	1.000	1.000
396	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA14(3), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(4), HAL(1)	12473657	23	22	23	6	1	3	2	16	1	0	0.538	1.000	1.000
397	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(6), EP300(11), IKBKB(1), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFBR2(1), TLR2(2)	19371642	36	32	30	6	2	4	4	12	13	1	0.333	1.000	1.000
398	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10593136	20	19	20	7	0	3	5	6	6	0	0.761	1.000	1.000
399	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(1), APOA2(1), CREBBP(6), EHHADH(5), EP300(11), FABP1(3), HSD17B4(1), JUN(2), LPL(2), MAPK3(1), ME1(1), MYC(1), NCOA1(3), NCOR1(4), NCOR2(7), NR1H3(3), NRIP1(6), PIK3CA(12), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PTGS2(4), RB1(2), RELA(5), SP1(2), SRA1(1), STAT5A(2), STAT5B(2)	40707164	103	74	91	19	5	19	13	40	25	1	0.0504	1.000	1.000
400	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(7), NRG2(3), NRG3(2), PRKCA(2)	6056416	14	14	14	5	1	4	1	6	2	0	0.730	1.000	1.000
401	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
402	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
403	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(2)	7898767	15	15	15	6	0	4	3	6	2	0	0.814	1.000	1.000
404	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(7), SHC1(3), SOS1(6), SYK(1), VAV1(3), VAV2(4)	20598662	43	37	39	9	5	6	3	18	10	1	0.304	1.000	1.000
405	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(4)	6631308	4	3	4	6	2	0	0	1	1	0	0.995	1.000	1.000
406	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(1), BRAF(2), CREB5(2), RAF1(1), SNX13(3), SRC(2)	7645801	13	10	13	5	0	5	1	5	1	1	0.745	1.000	1.000
407	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(3), AKT3(2), CASP8(1), CCL3(1), CD86(1), CHUK(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IKBKB(1), IKBKE(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(1), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), NFKB2(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(5), RIPK1(1), SPP1(3), STAT1(4), TBK1(2), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(4), TLR8(5), TLR9(1), TRAF3(1), TRAF6(2)	57605629	123	104	115	19	9	23	14	57	19	1	0.00517	1.000	1.000
408	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(5), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	15947146	35	32	31	9	2	5	4	13	10	1	0.627	1.000	1.000
409	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(11), MAPK3(1), PELP1(1), SRC(2)	9572843	21	18	18	7	2	3	4	6	6	0	0.704	1.000	1.000
410	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), PRKCA(2), RAF1(1), RELA(5)	9892034	18	18	15	6	4	3	0	5	5	1	0.725	1.000	1.000
411	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(4), IMPA2(3)	7466458	7	6	7	7	3	0	0	2	2	0	0.993	1.000	1.000
412	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(3), ILVBL(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(2), VARS2(2)	11227977	23	19	23	9	0	6	2	9	6	0	0.776	1.000	1.000
413	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NAGLU(2), NEU1(1), SPAM1(6)	21861110	53	44	51	11	7	8	7	23	8	0	0.116	1.000	1.000
414	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(5)	9877713	15	15	15	6	0	3	0	9	3	0	0.875	1.000	1.000
415	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAX(1), BID(1), BIK(1), BIRC2(3), BIRC3(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1)	8930987	14	14	14	5	0	2	2	6	4	0	0.788	1.000	1.000
416	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), PPP1R12B(1), PRKCA(2), ROCK1(4)	13493006	26	26	26	8	1	2	0	16	7	0	0.781	1.000	1.000
417	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(2), ARF1(1), BTK(1), EEA1(6), GSK3A(2), GSK3B(3), PFKL(1), PFKM(3), PFKP(2), PLCG1(2), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(4)	16531177	37	32	34	9	2	6	5	12	12	0	0.467	1.000	1.000
418	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(2), HRAS(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(3), PLCB1(1), PPP3CA(2), PPP3CC(3), RAC1(1), RAF1(1), RELA(5), SYT1(1)	25044200	61	49	55	13	6	7	3	21	23	1	0.387	1.000	1.000
419	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(16), ATR(7), BRCA1(7), BRCA2(8), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(1), RAD17(1), RAD50(4), RAD51(2), TP53(18), TREX1(2)	29412454	80	66	78	14	4	14	9	31	20	2	0.126	1.000	1.000
420	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC1B(1), ARPC2(8), CFL1(1), DIAPH1(3), GSN(2), LIMK1(4), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(7), VCL(2)	29634613	60	52	51	10	2	6	2	21	29	0	0.243	1.000	1.000
421	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(1), FYN(2), ITGA1(5), ITGB1(4), L1CAM(5), SELP(2)	10345754	20	18	19	8	2	3	2	8	5	0	0.850	1.000	1.000
422	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), ASRGL1(4), CA14(3), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(4), HAL(1)	13903166	27	26	24	7	1	3	2	16	5	0	0.562	1.000	1.000
423	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), GPI(3), PFKL(1), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(2), TKT(1), TKTL1(1), TKTL2(3)	15635698	31	30	29	9	1	5	4	10	11	0	0.683	1.000	1.000
424	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(7), AXIN1(3), AXIN2(1), CER1(1), CSNK1A1(2), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(2), GSK3A(2), GSK3B(3), LRP1(14), MVP(4), NKD1(2), NKD2(1), PTPRA(3), SENP2(1), WIF1(4)	26105870	63	54	59	13	4	10	8	22	19	0	0.148	1.000	1.000
425	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(1), BCHE(2), CES1(7), CES2(2), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2)	15191546	32	25	27	8	2	3	4	9	14	0	0.712	1.000	1.000
426	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT3(2), B4GALT5(1), DPAGT1(5), DPM1(1), MAN1A1(2), MGAT4A(3), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1)	12592340	24	24	24	9	0	6	0	11	7	0	0.834	1.000	1.000
427	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PLCG1(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2)	13912285	32	30	30	8	3	4	4	13	8	0	0.613	1.000	1.000
428	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2)	6422822	11	11	11	5	2	2	1	5	1	0	0.688	1.000	1.000
429	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3)	6802671	11	11	10	5	2	1	2	5	1	0	0.743	1.000	1.000
430	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BAX(1), BID(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CHUK(1), DFFB(1), FAS(1), FASLG(1), HELLS(2), IKBKB(1), IRF5(1), IRF6(5), IRF7(1), JUN(2), LTA(1), MAP3K1(6), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFRSF21(1), TNFSF10(6), TP53(18), TP73(3), TRADD(2), TRAF2(1), TRAF3(1)	36615953	85	64	73	17	3	11	9	27	32	3	0.250	1.000	1.000
431	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(1), GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), GTF2H2(2), ILK(4), MNAT1(1), POLR1A(4), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3B(3), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TAF7(1), TBP(1)	23174090	49	44	45	9	1	6	5	18	19	0	0.268	1.000	1.000
432	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(7), CALM2(1), CAPN2(2), EP300(11), HDAC1(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(2), PPP3CC(3), PRKCA(2), SYT1(1)	15555640	39	32	34	10	4	4	4	14	13	0	0.485	1.000	1.000
433	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(2), PRKCA(2), PTK2B(3), SYT1(1)	8980806	15	14	14	7	2	4	1	4	4	0	0.908	1.000	1.000
434	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(2), GNAI1(1), GNB1(2), GRB2(2), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(3), MYLK(4), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(6), STAT1(4), STAT3(3), STAT5A(2), SYT1(1)	27480771	59	52	57	12	4	9	6	24	16	0	0.306	1.000	1.000
435	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(1), FUT6(2), GBGT1(2), GCNT2(21), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(5), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	30918368	91	70	70	21	7	10	8	21	44	1	0.680	1.000	1.000
436	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(6), EP300(11), FYN(2), JAK1(5), JAK3(3), PIK3CA(12), PIK3R1(2), PTK2B(3), STAT5A(2), STAT5B(2)	18354788	48	43	41	11	1	10	9	16	12	0	0.315	1.000	1.000
437	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(3), BLVRA(1), COX10(2), COX15(1), CP(1), CPOX(6), EPRS(3), FECH(2), FTMT(3), GUSB(7), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), PPOX(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UROD(1)	27766131	69	60	61	15	5	8	9	28	19	0	0.300	1.000	1.000
438	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(2), VNN1(1)	11219940	22	21	22	8	1	4	4	8	5	0	0.752	1.000	1.000
439	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(1), ELK1(1), FOS(1), GAB1(1), GRB2(2), HGF(1), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAP4K1(2), MAPK3(1), MET(6), PAK1(2), PIK3CA(12), PIK3R1(2), PTEN(22), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(3)	29700800	88	69	83	19	5	20	4	27	31	1	0.260	1.000	1.000
440	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(8), CD19(1), CD22(4), CD72(1), CHUK(1), CR2(2), FOS(1), GSK3B(3), HRAS(1), IKBKB(1), INPP5D(2), JUN(2), KRAS(1), LILRB3(4), MALT1(2), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(4)	48185133	118	98	106	23	6	21	11	46	34	0	0.0971	1.000	1.000
441	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), SDHB(1)	16974815	31	30	27	8	4	5	6	7	9	0	0.409	1.000	1.000
442	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG1(1), ASL(4), CPS1(5), GATM(2), OAT(1), ODC1(2), OTC(1), PYCR1(1), SMS(2)	11356087	21	20	21	7	1	2	4	10	4	0	0.801	1.000	1.000
443	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(4), KHK(5), MPI(2), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(3), PFKP(2), PGM2(2), PMM1(1), RDH11(3), SORD(10), TPI1(1)	24272749	55	51	48	12	9	3	7	15	21	0	0.417	1.000	1.000
444	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1)	15775979	42	39	39	11	6	13	3	16	4	0	0.284	1.000	1.000
445	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), SOAT2(3)	15300366	27	25	24	8	2	2	2	13	8	0	0.864	1.000	1.000
446	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), CBL(2), CFLAR(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(4), JAK1(5), JAK3(3), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RAF1(1), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(6), STAT5A(2), STAT5B(2), SYK(1)	22934644	63	58	59	15	6	14	9	20	14	0	0.207	1.000	1.000
447	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GFPT1(1), GNE(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2)	11123051	14	13	14	6	3	0	2	6	3	0	0.858	1.000	1.000
448	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(4), POLH(5), POLI(3), POLK(3), POLL(2), POLM(3), POLQ(8), PRIM1(2), PRIM2(4), REV1(2), REV3L(13), RFC5(1)	27198763	68	54	62	14	4	4	4	33	23	0	0.485	1.000	1.000
449	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(1), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), JUN(2), LMNB1(3), MAP3K1(6), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(11), PTPN13(8), RB1(2), RIPK2(2), SPTAN1(6)	28042411	58	49	58	10	3	8	7	24	16	0	0.113	1.000	1.000
450	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSD(1), ARSE(1), CYP11B2(2), HSD17B2(1), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	17731963	24	22	24	6	2	3	3	7	9	0	0.468	1.000	1.000
451	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(9), CPS1(5), EPRS(3), GAD2(1), GCLC(1), GFPT1(1), GLS(4), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSS(1), NADSYN1(1), QARS(1)	21914311	42	35	38	9	2	4	7	15	13	1	0.474	1.000	1.000
452	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(5), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	10442846	23	21	23	8	2	4	2	10	5	0	0.606	1.000	1.000
453	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BAX(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), FAS(1), FASLG(1), JUN(2), MAP3K1(6), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(3), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFSF10(6), TP53(18), TRADD(2), TRAF2(1)	24064447	65	52	57	16	2	10	9	18	23	3	0.483	1.000	1.000
454	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(4), CR2(2), CSK(3), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPP5D(2), ITPR1(4), ITPR2(10), ITPR3(4), MAP4K1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(1), PIK3CA(12), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), PPP3CA(2), PPP3CC(3), PTPRC(6), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SYK(1), VAV1(3)	47914536	107	82	98	20	8	21	11	37	30	0	0.0278	1.000	1.000
455	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(1), ALAS1(5), ALAS2(3), AOC2(4), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(5), GATM(2), GLDC(3), MAOA(1), PISD(1), PLCB2(2), PLCG1(2), PLCG2(2), SARDH(4), SARS(3), SHMT1(2), SHMT2(3), TARS(6)	27427385	66	58	62	15	6	9	12	22	17	0	0.198	1.000	1.000
456	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(3), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(1), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SYK(1), VAV1(3)	33550726	68	57	64	13	5	16	8	27	12	0	0.0480	1.000	1.000
457	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(9), ATF4(2), BRAF(2), CACNA1C(10), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(6), EP300(11), GRIA1(6), GRIA2(3), GRIN1(2), GRIN2A(6), GRIN2B(6), GRM1(5), GRM5(8), HRAS(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PPP1R12A(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), RAP1A(1), RAPGEF3(2), RPS6KA1(7), RPS6KA6(1)	66267243	150	110	140	28	19	17	12	62	38	2	0.0417	1.000	1.000
458	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAF1(1), SYT1(1)	21997311	53	46	50	13	7	6	2	22	16	0	0.531	1.000	1.000
459	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(2), ARHGEF11(5), CDC42(1), DLG4(1), GNA13(4), LPA(6), MAP3K1(6), MAP3K5(5), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PLD1(3), PLD2(7), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(2)	31808522	71	60	67	14	4	8	8	31	20	0	0.201	1.000	1.000
460	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(4), FASN(3), OLAH(1), OXSM(1)	10057712	14	14	14	6	2	0	4	6	2	0	0.838	1.000	1.000
461	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(5), EGF(4), EGFR(10), ETS1(1), ETS2(1), FOS(1), HRAS(1), IKBKB(1), JUN(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), RAF1(1), RELA(5), RIPK1(1), SP1(2), TNFRSF1A(1), TRAF2(1)	31927150	77	62	71	17	10	7	3	29	27	1	0.449	1.000	1.000
462	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), CPEB1(3), EGFR(10), ERBB2(4), ERBB4(7), ETS1(1), ETS2(1), ETV6(2), FMN2(6), GRB2(2), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(8), NOTCH3(8), NOTCH4(5), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(6), SOS2(3), SPIRE1(1), SPIRE2(1)	32271932	86	71	83	19	11	8	11	36	18	2	0.303	1.000	1.000
463	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(1), ARSE(1), ASAH1(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1)	15163689	27	25	27	9	2	5	4	10	6	0	0.686	1.000	1.000
464	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(1), BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX11(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2), VAMP2(1)	11051827	16	14	16	8	2	2	2	8	2	0	0.865	1.000	1.000
465	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DFFB(1), LMNB1(3), PRF1(1)	12493614	22	21	22	7	0	6	3	9	4	0	0.639	1.000	1.000
466	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(12), PIK3R1(2), PTK2(1), PXN(1), RAF1(1), ROCK1(4), SHC1(3), SRC(2), TLN1(7)	24546785	60	55	56	14	4	13	4	22	17	0	0.314	1.000	1.000
467	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(6), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK2(2), PIK3CA(12), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(2), PPP3CC(3), RAF1(1), SHC1(3), SOS1(6), SYK(1), SYT1(1), VAV1(3)	27670642	71	62	65	17	6	14	6	24	21	0	0.317	1.000	1.000
468	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(4), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(2), CAMKK2(2), CHUK(1), CPT1A(1), CPT1C(4), CPT2(1), G6PC(3), IKBKB(1), IRS1(4), IRS4(1), JAK1(5), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), POMC(1), PPARGC1A(3), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4), PRKCQ(4), PTPN11(1), RELA(5), RXRB(4), RXRG(2), SLC2A1(1), SLC2A4(1), SOCS3(1), STAT3(3), STK11(1), TNFRSF1A(1), TRADD(2), TRAF2(1), TYK2(6)	52609862	129	97	110	27	5	17	18	47	41	1	0.252	1.000	1.000
469	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(2), AGT(1), AGTR1(2), ANPEP(7), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(6), REN(1), THOP1(1)	13831036	35	31	30	10	1	4	9	12	9	0	0.754	1.000	1.000
470	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), CABIN1(7), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(2), CDKN1A(1), CNR1(1), CREBBP(6), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(11), FOS(1), GATA3(2), GATA4(2), GRLF1(6), GSK3A(2), GSK3B(3), HRAS(1), ICOS(2), IFNA1(2), IFNB1(3), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PAK1(2), PPP3CC(3), PTPRC(6), RELA(5), SLA(1), SP1(2), SP3(2), TRAF2(1), TRPV6(4), VAV1(3), VAV2(4), XPO5(3)	58343361	145	104	133	29	12	19	16	53	44	1	0.0936	1.000	1.000
471	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(7), G6PD(2), GCLC(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(2), IDH1(2), IDH2(5), OPLAH(2), TXNDC12(1)	14138763	35	31	32	10	1	2	7	15	10	0	0.785	1.000	1.000
472	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(5), ACO1(4), CLYBL(2), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), OGDHL(2), PC(3), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	19614320	50	43	47	14	3	7	5	21	14	0	0.660	1.000	1.000
473	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DFFB(1), GAS2(3), MAP3K14(1), NFKB1(1), RELA(5), RIPK1(1), SPTAN1(6), TNFSF10(6), TRADD(2), TRAF2(1)	21839088	43	36	37	10	1	5	5	15	16	1	0.550	1.000	1.000
474	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(1), CPOX(6), EPRS(3), FECH(2), GUSB(7), HCCS(1), HMOX1(2), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UROD(1)	18053735	41	37	35	11	4	4	5	14	14	0	0.629	1.000	1.000
475	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), CREB5(2), DUSP10(1), EEF2K(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(2)	21858948	43	40	43	10	3	8	0	25	7	0	0.336	1.000	1.000
476	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(1), CAD(9), CPS1(5), EPRS(3), GAD2(1), GCLC(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(2), QARS(1)	26048357	47	38	43	10	3	4	9	16	14	1	0.411	1.000	1.000
477	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(1), AGPS(1), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLD1(3), PLD2(7), PPAP2B(1), PPAP2C(2)	15330061	26	24	23	9	3	2	4	11	6	0	0.762	1.000	1.000
478	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(2), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), MAPK7(1), PLD1(3), PLD2(7), PLD3(3), PTK2(1), RAF1(1), RASAL1(5), SRC(2), TEC(6), VAV1(3)	17863193	45	40	39	12	4	3	5	18	15	0	0.721	1.000	1.000
479	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX5(2), CYP1A2(3), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP3A7(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), RDH11(3)	15699422	24	24	23	8	4	2	3	11	4	0	0.610	1.000	1.000
480	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SULT2A1(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	32479861	51	46	51	11	5	7	7	19	13	0	0.287	1.000	1.000
481	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(2), ASAH1(2), BRAF(2), DRD2(1), EGFR(10), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), PIK3CB(3), PITX2(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SRC(2), STAT3(3)	38247862	83	62	81	18	9	13	13	32	15	1	0.116	1.000	1.000
482	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(5), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADH(1), HADHA(2), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), TPH1(1), TPH2(1), WARS(1), WARS2(4)	39559123	77	65	70	16	4	13	12	29	19	0	0.196	1.000	1.000
483	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFB(1), JUN(2), LMNB1(3), MADD(6), MAP3K1(6), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(11), RB1(2), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	25861196	51	45	51	11	1	9	7	18	16	0	0.246	1.000	1.000
484	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(7), ASAH1(2), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), PITX2(2), RAC1(1), RHO(1), RYR1(13)	29642229	53	48	53	12	9	8	8	20	8	0	0.140	1.000	1.000
485	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CEL(1), DAK(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(5), GPAM(2), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2)	38525819	73	60	70	16	6	12	10	24	21	0	0.236	1.000	1.000
486	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), CASP1(2), CASP7(1), CASP8(1), GAPDH(2), INSR(6), MAGI1(4), MAGI2(4), RERE(3), WWP2(3)	15438477	35	31	26	10	4	4	4	9	12	2	0.872	1.000	1.000
487	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(1), ALG6(2), ALG8(2), B4GALT3(2), DOLPP1(2), DPAGT1(5), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), RFT1(1), RPN1(2), RPN2(1), STT3B(3)	27562098	59	49	58	14	0	14	2	24	19	0	0.461	1.000	1.000
488	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(2), HERPUD1(1), HSPA8(7), IDI1(1), KLF9(2), MYF6(2), NCKAP1(2), NCOA4(5), NR1D2(1), PER1(5), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(6)	23817899	59	52	58	14	2	10	11	21	14	1	0.273	1.000	1.000
489	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(16), CCNA1(8), CCND2(1), CCNE1(2), CCNE2(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(3), E2F1(1), E2F5(1), GBA2(4), MCM2(6), MCM5(2), MCM6(3), MCM7(5), MNAT1(1), MYC(1), MYT1(2), NACA(10), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(2), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(5), TP53(18), WEE1(1)	49024551	132	87	116	28	8	14	14	43	51	2	0.289	1.000	1.000
490	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(1), ADC(1), AGMAT(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), ARG1(1), ASL(4), ASS1(2), CPS1(5), GATM(2), MAOA(1), ODC1(2), OTC(1), SAT1(1), SAT2(1), SMS(2)	19122684	46	43	44	13	1	6	8	19	12	0	0.654	1.000	1.000
491	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(1), CD4(10), CD74(1), CD8A(1), CIITA(3), CTSB(3), CTSL1(2), CTSS(1), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-E(2), HLA-F(2), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), KIR2DL3(1), KIR2DS4(1), KIR3DL1(3), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), NFYC(2), RFX5(1), RFXAP(1), TAP2(1)	27085430	78	63	71	21	4	10	7	31	25	1	0.831	1.000	1.000
492	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(5), ACACB(4), ACADM(1), ACSS1(3), ACSS2(7), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(5), HADHA(2), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	26298582	61	51	56	16	3	7	15	15	20	1	0.513	1.000	1.000
493	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(4), KHK(5), MPI(2), PFKFB3(1), PFKM(3), PFKP(2), PMM1(1), SORD(10), TPI1(1)	15651531	42	39	35	13	5	2	5	10	20	0	0.880	1.000	1.000
494	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(2), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	17018286	24	23	24	8	0	5	6	10	3	0	0.587	1.000	1.000
495	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(5), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(3), C1S(16), C2(2), C3(6), C3AR1(1), C4BPA(3), C4BPB(2), C5(5), C5AR1(2), C6(1), C7(3), C8A(1), C8B(2), C8G(1), CD55(1), CFB(5), CFH(5), CFI(1), CPB2(5), CR1(7), CR2(2), F11(1), F12(3), F13A1(1), F13B(2), F2(3), F5(8), F7(1), F8(5), F9(2), FGA(2), FGG(5), KLKB1(2), KNG1(2), MASP1(2), MASP2(1), MBL2(1), PLAT(4), PLAU(4), PLAUR(2), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPIND1(2), SERPINF2(2), SERPING1(3), TFPI(1), VWF(11)	58915164	168	116	147	31	13	20	16	74	43	2	0.0248	1.000	1.000
496	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CSK(3), CTLA4(1), DTYMK(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(2), ITK(2), ITPKA(1), ITPKB(1), LCP2(1), NCK1(1), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLCG1(2), PTPRC(6), RAF1(1), RASGRP1(2), RASGRP2(4), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(3), VAV1(3)	36156246	75	60	72	17	6	10	8	30	21	0	0.423	1.000	1.000
497	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), HADHA(2), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	21966427	47	43	43	13	3	5	11	14	14	0	0.533	1.000	1.000
498	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GALM(2), GAPDH(2), GAPDHS(2), GPI(3), HK1(4), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKL(1), PFKM(3), PFKP(2), PGAM1(1), PGAM2(1), PGK1(3), PKM2(1), TPI1(1)	37949123	88	69	79	22	6	7	11	30	33	1	0.609	1.000	1.000
499	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ALG6(2), CCKBR(2), CELSR1(12), CELSR2(6), CELSR3(5), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(2), EMR3(9), FSHR(2), GPR116(4), GPR133(3), GPR17(2), GPR61(1), GPR77(1), GPR84(4), GRM1(5), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(9), NTSR1(1), OR8G1(2), OR8G2(2), P2RY13(1), PTGFR(3), SMO(3), TSHR(2)	41481571	96	74	92	23	14	17	6	34	25	0	0.162	1.000	1.000
500	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(13), B3GALT4(1), CDR1(2), DGKI(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL23(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(2), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(1), RPS19(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS9(1), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(3)	33964219	86	75	81	19	5	7	17	32	24	1	0.346	1.000	1.000
501	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK3(2), PDP2(2), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	18653873	44	36	41	13	1	7	6	17	13	0	0.666	1.000	1.000
502	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PKM2(1)	24117765	49	44	46	13	2	6	7	14	20	0	0.610	1.000	1.000
503	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(3), ACSM1(1), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(5), GAD2(1), HADH(1), HADHA(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(3), RDH11(3)	26710355	50	44	46	13	7	7	7	15	14	0	0.419	1.000	1.000
504	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(6), CTBP1(1), CTBP2(2), DLL1(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(1), DTX4(4), DVL1(1), DVL2(1), EP300(11), HDAC1(2), JAG1(5), JAG2(2), MAML1(5), MAML2(2), MAML3(6), NCOR2(7), NCSTN(1), NOTCH1(5), NOTCH2(8), NOTCH3(8), NOTCH4(5), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), PTCRA(1), RBPJ(2), RBPJL(7), SNW1(3)	41783564	111	80	101	28	9	10	15	36	39	2	0.549	1.000	1.000
505	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(5), GSK3B(3), HHIP(3), LRP2(18), PRKACA(1), PRKACB(5), PRKACG(2), PTCH1(10), PTCH2(2), SHH(1), SMO(3), STK36(2), SUFU(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	37361099	96	78	86	24	10	10	7	44	25	0	0.514	1.000	1.000
506	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GAPDHS(2), GOT1(3), GOT2(2), GPI(3), HK1(4), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(3), PFKP(2), PGAM1(1), PGAM2(1), PGK1(3), PKM2(1), TNFAIP1(1), TPI1(1)	27486661	68	55	64	19	4	6	9	20	29	0	0.658	1.000	1.000
507	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(4), ACSS1(3), ACSS2(7), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(2), PDHB(1), PKM2(1)	30516346	63	53	59	16	2	8	11	15	26	1	0.581	1.000	1.000
508	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(1), ASAH1(2), B4GALT6(1), CERK(5), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(2), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2)	22215704	43	39	40	13	6	7	6	13	11	0	0.587	1.000	1.000
509	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), ENTPD5(1), NME7(1), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(4), RFC5(1), RRM1(3), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(2)	53777536	98	77	89	20	3	17	12	32	33	1	0.114	1.000	1.000
510	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT6(1), CDS2(1), CHAT(4), CHKB(2), CHPT1(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(2), LCAT(1), LYPLA1(1), MYST3(4), MYST4(3), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLD1(3), PLD2(7), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(2)	42731591	72	57	67	16	9	8	10	24	21	0	0.255	1.000	1.000
511	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(6), DARS(1), EPRS(3), HARS(1), IARS(4), KARS(1), LARS(3), LARS2(2), MARS(2), MARS2(3), QARS(1), RARS(2), SARS(3), TARS(6), WARS(1), WARS2(4), YARS(1)	21368148	46	38	41	12	0	5	7	22	12	0	0.573	1.000	1.000
512	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(2), CERK(5), CREB5(2), EPHB2(2), FOS(1), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	17965013	32	29	29	10	5	4	3	12	8	0	0.695	1.000	1.000
513	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), CEL(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(5), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNLIPRP2(1), PPAP2B(1), PPAP2C(2)	31560764	59	48	56	16	6	11	6	18	18	0	0.518	1.000	1.000
514	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(3), FYN(2), GRB2(2), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAPK3(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(1), RAP1A(1), ROCK1(4), SHC1(3), SOS1(6), SRC(2), TLN1(7), VCL(2), ZYX(1)	30457734	61	51	60	16	5	9	2	29	16	0	0.589	1.000	1.000
515	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(2), DHRS4(3), EPHX2(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(4), TBXAS1(3)	25276434	56	49	53	15	6	6	12	20	11	1	0.384	1.000	1.000
516	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GPI(3), HK1(4), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGAM1(1), PGK1(3), PKM2(1), TPI1(1)	31870819	71	57	63	20	6	4	7	27	27	0	0.780	1.000	1.000
517	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GPI(3), HK1(4), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGAM1(1), PGK1(3), PKM2(1), TPI1(1)	31870819	71	57	63	20	6	4	7	27	27	0	0.780	1.000	1.000
518	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), F11(1), F12(3), F2(3), F5(8), F8(5), F9(2), FGA(2), FGG(5), KLKB1(2), PROC(4), PROS1(4), SERPING1(3)	29418959	63	57	61	19	6	13	4	23	16	1	0.549	1.000	1.000
519	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), ATP7A(3), ATP7B(6), COX10(2), COX6A2(1), COX7A2(1), NDUFA1(1), NDUFA10(2), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(1)	25317507	56	48	55	16	3	11	9	22	11	0	0.479	1.000	1.000
520	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(4), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(2), CAPN2(2), CAV2(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(10), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), CTNNB1(1), DIAPH1(3), DOCK1(1), EGF(4), EGFR(10), ELK1(1), ERBB2(4), FARP2(2), FIGF(2), FLNA(4), FLNB(4), FLNC(5), FLT1(9), FN1(4), FYN(2), GRB2(2), GRLF1(6), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), JUN(2), KDR(5), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), MAPK10(1), MAPK3(1), MAPK9(2), MET(6), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARVB(1), PARVG(1), PDGFC(1), PDGFD(2), PDGFRA(7), PDGFRB(1), PGF(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(2), PRKCA(2), PRKCG(2), PTEN(22), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(5), ROCK1(4), ROCK2(3), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SPP1(3), SRC(2), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TLN1(7), TLN2(9), TNC(8), TNN(3), TNR(8), TNXB(5), VAV1(3), VAV2(4), VCL(2), VEGFC(2), VTN(1), VWF(11), ZYX(1)	239556698	557	273	533	156	54	82	59	200	159	3	0.423	1.000	1.000
521	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY7(1), ADCY8(9), ADCY9(4), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), ATP2B4(3), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(8), CACNA1H(4), CACNA1I(4), CACNA1S(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(3), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(4), ERBB3(6), ERBB4(7), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(6), GRM1(5), GRM5(8), GRPR(1), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), MYLK(4), MYLK2(1), NOS1(9), NOS3(3), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), PDE1A(1), PDE1B(5), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PTAFR(2), PTGER3(5), PTGFR(3), PTK2B(3), RYR1(13), RYR2(11), RYR3(12), SLC25A4(2), SLC25A5(1), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(4), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(2), TRHR(2), TRPC1(2), VDAC3(1)	176508822	398	245	380	108	59	49	33	161	96	0	0.209	1.000	1.000
522	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(2), ARRB2(1), ATF2(1), ATF4(2), BRAF(2), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(8), CACNA1H(4), CACNA1I(4), CACNA1S(8), CACNA2D1(3), CACNA2D2(1), CACNA2D4(4), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CDC25B(1), CDC42(1), CHUK(1), DAXX(5), DUSP10(1), DUSP3(2), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(4), EGF(4), EGFR(10), ELK1(1), ELK4(2), FAS(1), FASLG(1), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(4), FGFR4(3), FLNA(4), FLNB(4), FLNC(5), FOS(1), GNA12(1), GNG12(1), GRB2(2), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(4), JUN(2), KRAS(1), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(2), MAP4K2(1), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAPT(3), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(9), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NTRK1(6), NTRK2(1), PAK1(2), PAK2(2), PDGFRA(7), PDGFRB(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PPM1B(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PPP5C(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PTPN5(3), PTPN7(1), PTPRR(4), RAC1(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(7), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(3), RASGRP1(2), RASGRP2(4), RASGRP3(1), RASGRP4(2), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KA6(1), RRAS2(8), SOS1(6), SOS2(3), SRF(1), TAOK2(3), TAOK3(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TP53(18), TRAF2(1), TRAF6(2), ZAK(3)	187165167	433	244	408	98	43	56	41	166	123	4	0.0475	1.000	1.000
523	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), APC(7), ARHGEF1(2), ARHGEF12(2), ARHGEF6(2), ARHGEF7(5), ARPC1B(1), ARPC2(8), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(2), C3orf10(2), CDC42(1), CFL1(1), CHRM2(3), CHRM3(2), CHRM5(2), CSK(3), CYFIP1(5), CYFIP2(6), DIAPH1(3), DIAPH2(2), DIAPH3(4), DOCK1(1), EGF(4), EGFR(10), EZR(1), F2(3), FGD1(3), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(4), FGFR4(3), FN1(4), GIT1(2), GNA12(1), GNA13(4), GNG12(1), GRLF1(6), GSN(2), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(5), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAD(9), ITGAE(6), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(1), LIMK1(4), LIMK2(2), MAPK3(1), MOS(1), MRAS(1), MSN(2), MYH10(2), MYH14(4), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), NCKAP1(2), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), RDX(1), ROCK1(4), ROCK2(3), RRAS2(8), SCIN(2), SLC9A1(2), SOS1(6), SOS2(3), SSH1(2), SSH2(8), SSH3(2), TIAM1(6), TIAM2(1), VAV1(3), VAV2(4), VCL(2), WASF2(2), WASL(6)	181384471	406	227	371	96	26	52	47	154	126	1	0.168	1.000	1.000
524	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(2), CHAD(2), COL11A1(10), COL11A2(4), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), DSC2(3), DSG1(3), DSG2(2), DSG3(2), DSG4(2), FN1(4), GJA10(2), GJA3(1), GJA4(1), GJA5(5), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(2), KRT19(1), KRT2(3), KRT23(2), KRT24(1), KRT25(1), KRT27(2), KRT28(2), KRT3(1), KRT31(1), KRT33B(2), KRT35(1), KRT36(2), KRT39(1), KRT4(3), KRT5(2), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(3), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT77(1), KRT78(3), KRT79(4), KRT82(2), KRT83(1), KRT84(2), KRT85(4), KRT86(1), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), LMNB1(3), NES(8), PRPH(1), RELN(5), SPP1(3), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TNC(8), TNN(3), TNR(8), TNXB(5), VIM(1), VTN(1), VWF(11)	157743068	360	215	347	121	39	53	36	122	109	1	0.900	1.000	1.000
525	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), C5AR1(2), CALCR(2), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(3), CHRM3(2), CHRM5(2), CNR1(1), CNR2(2), CRHR1(1), CRHR2(2), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GABBR1(3), GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(7), GABRR1(2), GABRR2(1), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(2), GLRA2(1), GLRB(2), GPR156(1), GPR35(2), GPR50(1), GPR63(1), GPR83(1), GRIA1(6), GRIA2(3), GRIA3(2), GRIA4(3), GRID1(3), GRID2(6), GRIK1(3), GRIK2(4), GRIK3(4), GRIK5(4), GRIN1(2), GRIN2A(6), GRIN2B(6), GRIN3B(2), GRM1(5), GRM2(2), GRM3(3), GRM4(3), GRM5(8), GRM6(2), GRM7(4), GRM8(3), GRPR(1), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), LEP(1), LEPR(1), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(3), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(1), P2RY8(2), PARD3(5), PRLR(2), PRSS3(3), PTAFR(2), PTGDR(1), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(3), PTGIR(1), RXFP1(1), RXFP2(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(2), THRA(2), TRHR(2), TSHR(2), VIPR1(1)	140192782	307	196	294	94	44	43	26	118	76	0	0.567	1.000	1.000
526	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD44(2), CHAD(2), COL11A1(10), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), FN1(4), FNDC1(1), FNDC3A(3), FNDC5(1), HMMR(1), HSPG2(10), IBSP(1), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), RELN(5), SDC3(1), SPP1(3), SV2A(1), SV2B(1), SV2C(2), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TNC(8), TNN(3), TNR(8), TNXB(5), VTN(1), VWF(11)	142965294	307	196	297	99	31	45	32	104	94	1	0.840	1.000	1.000
527	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(5), CASK(1), CDC42(1), CDK4(6), CGN(1), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), EPB41(2), EPB41L1(1), EPB41L2(2), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), IGSF5(4), INADL(4), JAM3(1), KRAS(1), LLGL1(5), LLGL2(2), MAGI1(4), MAGI2(4), MAGI3(4), MLLT4(8), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH10(2), MYH11(8), MYH13(4), MYH14(4), MYH15(3), MYH2(9), MYH3(6), MYH4(10), MYH6(4), MYH7(8), MYH7B(5), MYH8(5), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLPF(3), OCLN(2), PARD3(5), PARD6B(4), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), PTEN(22), RRAS2(8), SPTAN1(6), SRC(2), TJAP1(1), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(3)	127258964	300	181	277	78	30	37	21	93	117	2	0.476	1.000	1.000
528	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB2(1), ATP1A4(4), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1S(8), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(4), CASQ2(2), CHRM2(3), CHRM3(2), CHRM5(2), GJA4(1), GJA5(5), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(2), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GRK4(1), GRK5(1), GRK6(5), ITPR1(4), ITPR2(10), ITPR3(4), KCNB1(1), KCNJ3(3), MYCBP(1), NME7(1), PKIA(1), PLCB3(2), PRKACA(1), PRKACB(5), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS3(6), RGS6(2), RGS7(1), RGS9(4), RYR1(13), RYR2(11), RYR3(12), SLC8A1(1), SLC8A3(4), USP5(2)	124492271	269	177	260	73	42	34	23	100	70	0	0.222	1.000	1.000
529	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(1), ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(2), BMP7(3), BMPR1B(1), BMPR2(5), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(6), CSF2RA(4), CSF2RB(1), CSF3R(3), CX3CR1(1), CXCL11(1), CXCL16(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(10), FAS(1), FASLG(1), FLT1(9), FLT3(6), FLT4(7), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(4), IL20RA(1), IL21(1), IL21R(3), IL22(1), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTB(1), LTBR(2), MET(6), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF10C(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(6), TNFSF14(1), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(4), VEGFC(2), XCL1(2), XCR1(1)	115120482	251	173	237	51	17	36	25	109	64	0	0.0340	1.000	1.000
530	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ARRB2(1), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(6), ATP2A3(4), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GBA2(4), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GRK4(1), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(3), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(10), ITPR3(4), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(9), NOS3(3), PDE4B(2), PDE4D(2), PKIA(1), PLCB3(2), PLCD1(1), PLCG1(2), PLCG2(2), PRKACA(1), PRKACB(5), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS3(6), RGS6(2), RGS7(1), RGS9(4), RLN1(1), RYR1(13), RYR2(11), RYR3(12), SLC8A1(1), SP1(2), TNXB(5), USP5(2)	112147180	246	170	239	60	35	34	23	92	62	0	0.198	1.000	1.000
531	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(5), ABLIM1(4), ABLIM2(1), ABLIM3(3), ARHGEF12(2), CDC42(1), CFL1(1), CXCR4(1), DCC(4), DPYSL2(3), EFNA3(1), EFNB1(1), EFNB3(12), EPHA1(3), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(2), EPHB4(4), EPHB6(5), FES(3), FYN(2), GNAI1(1), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(2), MAPK3(1), MET(6), NCK1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NGEF(1), NRP1(2), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(3), PLXNC1(3), PPP3CA(2), PPP3CC(3), PPP3R2(2), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(6), RND1(3), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(6), SEMA4G(2), SEMA5A(5), SEMA5B(1), SEMA6C(4), SEMA6D(3), SLIT1(2), SLIT2(7), SLIT3(6), SRGAP1(4), SRGAP2(2), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(2), UNC5D(2)	125480090	271	169	240	71	21	33	24	96	96	1	0.636	1.000	1.000
532	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(5), ACACB(4), AKT1(2), AKT2(3), AKT3(2), BRAF(2), CALM2(1), CBL(2), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(3), FBP1(1), FLOT1(1), FLOT2(1), FOXO1(2), G6PC(3), GRB2(2), GSK3B(3), GYS1(3), GYS2(1), HRAS(1), IKBKB(1), INPP5D(2), INSR(6), IRS1(4), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(2), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(3), PHKG2(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2), PRKCI(2), PRKCZ(2), PTPN1(1), PTPRF(4), PYGB(2), PYGL(1), PYGM(3), RAF1(1), RAPGEF1(4), RHEB(4), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(1), SHC3(1), SLC2A4(1), SOCS3(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(3), SREBF1(2), TRIP10(1), TSC1(2), TSC2(6)	102633158	227	162	211	39	19	34	27	93	53	1	0.00271	1.000	1.000
533	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(5), ASH2L(2), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(4), EZH1(2), EZH2(4), FBXO11(3), HCFC1(6), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(4), MEN1(1), MLL(5), MLL2(11), MLL3(15), MLL4(3), MLL5(6), NSD1(8), OGT(4), PAXIP1(1), PRDM2(1), PRDM6(1), PRDM7(4), PRDM9(3), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(2), SETD1A(4), SETD1B(1), SETD2(59), SETD7(1), SETDB1(6), SETMAR(2), SMYD3(2), SUV39H2(4), SUV420H1(2), SUZ12(5), WHSC1(5), WHSC1L1(5)	79066801	216	158	212	41	12	26	25	67	83	3	0.0244	1.000	1.000
534	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(7), AXIN1(3), AXIN2(1), BTRC(2), CACYBP(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(3), CREBBP(6), CSNK1A1(2), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(2), CTNNB1(1), CUL1(3), CXXC4(2), DAAM1(2), DKK2(1), DVL1(1), DVL2(1), EP300(11), FBXW11(1), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GSK3B(3), JUN(2), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), MAPK9(2), MYC(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), TP53(18), VANGL1(1), VANGL2(3), WIF1(4), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	102183611	228	155	215	57	16	24	28	90	68	2	0.311	1.000	1.000
535	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(2), AKT2(3), AKT3(2), CBL(2), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(6), CSF2RA(4), CSF2RB(1), CSF3R(3), EP300(11), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL20RA(1), IL21(1), IL21R(3), IL22(1), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(5), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(4), PIAS2(1), PIAS3(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(1), SOS1(6), SOS2(3), SPRED1(6), SPRED2(1), SPRY1(1), SPRY2(2), SPRY4(10), STAM(2), STAT1(4), STAT2(6), STAT3(3), STAT4(1), STAT5A(2), STAT5B(2), STAT6(4), TPO(4), TYK2(6)	94558184	231	152	214	52	13	38	34	88	58	0	0.102	1.000	1.000
536	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(3), CADM1(2), CADM3(1), CD2(2), CD22(4), CD28(1), CD34(2), CD4(10), CD6(2), CD86(1), CD8A(1), CD99(1), CDH1(2), CDH2(6), CDH3(3), CDH4(5), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CNTN1(4), CNTN2(2), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(4), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-E(2), HLA-F(2), ICAM1(1), ICOS(2), ICOSLG(1), ITGA4(2), ITGA6(4), ITGA9(2), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(4), ITGB2(1), ITGB7(3), ITGB8(1), JAM3(1), L1CAM(5), MPZL1(1), NCAM1(1), NCAM2(2), NEGR1(2), NEO1(2), NFASC(5), NRCAM(3), NRXN1(7), NRXN2(4), NRXN3(4), OCLN(2), PTPRC(6), PTPRF(4), PTPRM(3), PVRL2(3), PVRL3(2), SDC3(1), SELE(5), SELP(2), SELPLG(2), SIGLEC1(3), SPN(1), VCAM1(3), VCAN(7)	93306626	214	144	203	69	18	28	27	87	53	1	0.853	1.000	1.000
537	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), CANT1(1), ENPP3(1), ENTPD2(1), ENTPD5(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(1), NME7(1), NPR1(4), NPR2(4), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT5(3), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(5), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(1), PDE8A(2), PDE8B(1), PDE9A(8), PFAS(2), PKM2(1), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(4), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RFC5(1), RRM1(3), RRM2(1), XDH(6)	107731605	204	138	190	38	15	27	20	76	66	0	0.0474	1.000	1.000
538	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ATF4(2), CACNA1C(10), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(1), GNAS(4), GRB2(2), HRAS(1), ITPR1(4), ITPR2(10), ITPR3(4), JUN(2), KRAS(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK9(2), MMP14(1), MMP2(7), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLD1(3), PLD2(7), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCD(3), PTK2B(3), RAF1(1), SOS1(6), SOS2(3), SRC(2)	84485985	200	138	195	47	26	28	21	85	40	0	0.0740	1.000	1.000
539	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(5), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), ATM(16), ATR(7), BUB1B(1), BUB3(1), CCNA1(8), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNH(1), CDC14A(5), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(2), CDC27(2), CDC6(1), CDC7(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(6), CUL1(3), E2F1(1), EP300(11), ESPL1(8), FZR1(4), GSK3B(3), HDAC1(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(11), RB1(2), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), TP53(18), WEE1(1), YWHAE(1)	90202137	209	136	193	45	13	27	25	71	70	3	0.0826	1.000	1.000
540	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(2), CREBBP(6), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), CTNND1(5), EGFR(10), EP300(11), ERBB2(4), FARP2(2), FER(2), FGFR1(5), FYN(2), IGF1R(1), INSR(6), IQGAP1(5), LEF1(1), LMO7(11), MAP3K7(1), MAPK3(1), MET(6), MLLT4(8), PARD3(5), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(4), PTPRJ(7), PTPRM(3), PVRL2(3), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(2), WASF3(3), WASL(6), YES1(1)	78785612	186	135	168	46	19	20	26	70	51	0	0.340	1.000	1.000
541	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), ARHGAP5(4), BCAR1(3), CD99(1), CDC42(1), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), CTNND1(5), CXCR4(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), ITK(2), JAM3(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(8), MMP2(7), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), MYLPF(3), NCF1(1), NCF2(1), NOX1(6), NOX3(4), OCLN(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), SIPA1(1), VAV1(3), VAV2(4), VCAM1(3), VCL(2)	81195193	188	133	175	52	20	28	20	63	57	0	0.456	1.000	1.000
542	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), DRD1(1), DRD2(1), EGF(4), EGFR(10), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(2), GRM1(5), GRM5(8), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), PDGFC(1), PDGFD(2), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), SOS1(6), SOS2(3), SRC(2), TJP1(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1)	85841526	195	132	190	47	21	26	20	80	48	0	0.245	1.000	1.000
543	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(6), CAPN5(1), CAPN6(2), CAPN7(1), CAPN9(2), CAV2(1), CDC42(1), CSK(3), DOCK1(1), FYN(2), GIT2(2), GRB2(2), ILK(4), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAD(9), ITGAE(6), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K3(3), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(1), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAPGEF1(4), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(2), SHC1(3), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(7), TNS1(7), VAV2(4), VCL(2), ZYX(1)	88189962	186	131	177	53	11	31	21	72	51	0	0.632	1.000	1.000
544	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(3), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(4), MYBPC3(1), MYH3(6), MYH6(4), MYH7(8), MYH8(5), MYL1(3), MYL2(1), MYL9(1), MYOM1(5), NEB(13), TMOD1(5), TNNI1(1), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TTN(92), VIM(1)	93467529	171	130	167	47	16	32	15	69	36	3	0.385	1.000	1.000
545	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(5), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(2), ARHGEF7(5), BCAR1(3), BRAF(2), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(2), FYN(2), GRB2(2), GRB7(2), GRLF1(6), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), MAP2K7(1), MAP3K11(2), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(12), PIK3CB(3), PLCG1(2), PLCG2(2), PTEN(22), PTK2(1), RAF1(1), RALA(2), RHO(1), ROCK1(4), ROCK2(3), SHC1(3), SOS1(6), SOS2(3), SRC(2), TLN1(7), TLN2(9), ZYX(1)	79963137	197	129	188	42	9	38	20	67	61	2	0.0751	1.000	1.000
546	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(2), INPP5E(2), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), OCRL(2), PI4KA(9), PI4KB(3), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3C3(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(2), PTEN(22), PTPMT1(2), SYNJ1(5), SYNJ2(6)	82461019	183	127	173	47	15	31	14	64	57	2	0.322	1.000	1.000
547	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), AKAP1(2), AKAP10(1), AKAP11(2), AKAP12(5), AKAP3(1), AKAP4(3), AKAP6(5), AKAP7(1), AKAP8(2), AKAP9(19), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA12(1), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(2), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(4), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(5), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE8A(2), PDE8B(1), PLCB3(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), PRKD1(3), PRKD3(3), SLC9A1(2), USP5(2)	76969295	180	125	174	39	20	22	7	77	53	1	0.135	1.000	1.000
548	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(1), BRAF(2), CD48(1), FAS(1), FASLG(1), FCGR3B(1), FYN(2), GRB2(2), HCST(1), HLA-B(1), HLA-C(2), HLA-E(2), HRAS(1), ICAM1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), ITGAL(5), ITGB2(1), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(2), NCR1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK1(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SYK(1), TNFRSF10C(1), TNFSF10(6), ULBP2(1), ULBP3(1), VAV1(3), VAV2(4)	72635902	172	124	160	45	10	30	22	64	45	1	0.450	1.000	1.000
549	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(2), CACNA1A(5), CRHR1(1), GNA12(1), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(2), GRID2(6), GRM1(5), GRM5(8), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HRAS(1), IGF1R(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAPK3(1), NOS1(9), NOS3(3), NPR1(4), NPR2(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), RYR1(13)	72272749	161	123	158	49	26	17	13	66	38	1	0.663	1.000	1.000
550	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(4), NPR2(4), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(2), PDE8A(2), PDE9A(8), PFAS(2), PKM2(1), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RRM1(3), RRM2(1)	83661134	173	123	162	31	17	20	16	66	54	0	0.0441	1.000	1.000
551	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(4), AKT1(2), AURKB(1), BMPR2(5), CDKL1(1), CDS2(1), CLK1(4), CLK2(2), CLK4(3), COL4A3BP(2), CSNK2A2(1), CSNK2B(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(3), MOS(1), NEK1(3), NEK3(3), OCRL(2), PAK4(2), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3CA(12), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCG1(2), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), PRKG1(3), RAF1(1), RPS6KA1(7), RPS6KA4(1), RPS6KB1(2), STK11(1)	74646129	160	118	150	37	11	28	10	60	50	1	0.254	1.000	1.000
552	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR6(1), CCR9(1), CHML(1), CHRM2(3), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(2), GPR174(2), GPR35(2), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(1), GPR85(2), GPR87(1), GRPR(1), HCRTR2(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(2), OPRD1(2), OPRM1(3), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(2), OR8B8(2), P2RY1(1), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(2)	74811985	145	117	143	51	26	18	15	59	27	0	0.651	1.000	1.000
553	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(4), ABCA12(9), ABCA13(18), ABCA2(3), ABCA3(3), ABCA4(7), ABCA5(7), ABCA6(3), ABCA7(7), ABCA8(4), ABCA9(3), ABCB1(4), ABCB11(3), ABCB4(5), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(8), ABCC10(4), ABCC11(5), ABCC12(3), ABCC2(1), ABCC3(10), ABCC4(5), ABCC5(4), ABCC6(5), ABCC8(4), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(5), ABCG5(2), ABCG8(3), CFTR(5), TAP2(1)	77455409	168	117	157	44	6	30	20	68	43	1	0.281	1.000	1.000
554	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(5), ABL2(5), AKT1(2), AKT2(3), AKT3(2), BRAF(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(10), ELK1(1), ERBB2(4), ERBB3(6), ERBB4(7), GAB1(1), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NCK1(1), NRG1(4), NRG2(3), NRG3(2), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), RAF1(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SRC(2), STAT5A(2), STAT5B(2)	66806047	160	116	149	30	12	30	22	60	35	1	0.0247	1.000	1.000
555	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(2), ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(2), ALG8(2), B3GNT1(1), B3GNT2(3), B3GNT6(1), B3GNT7(1), B4GALT3(2), B4GALT4(3), B4GALT5(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(1), CHST4(1), CHST7(1), CHSY1(9), DPAGT1(5), EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(1), GALNT1(1), GALNT10(5), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(2), NDST2(3), NDST4(5), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(3), WBSCR17(4), XYLT1(2), XYLT2(2)	70053130	168	115	151	44	6	28	16	57	61	0	0.591	1.000	1.000
556	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(5), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(2), ENPP3(1), EP400(8), ERCC2(1), ERCC3(1), G6PC(3), GAA(1), GANC(2), GBA(2), GBA3(2), GBE1(1), GPI(3), GUSB(7), GYS1(3), GYS2(1), HK1(4), IFIH1(2), MGAM(6), MOV10L1(5), NUDT5(3), PYGB(2), PYGL(1), PYGM(3), RAD54L(2), RUVBL2(2), SETX(7), SI(6), SMARCA2(5), SMARCA5(1), UGP2(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UXS1(1)	81764248	152	114	144	53	7	25	23	45	52	0	0.913	1.000	1.000
557	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BMPR1B(1), BMPR2(5), CHRD(3), CREBBP(6), CUL1(3), DCN(3), E2F5(1), EP300(11), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(2), MAPK3(1), MYC(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(2), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(1), SMAD5(1), SMAD9(1), SMURF2(3), SP1(2), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(11), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(6)	63765341	147	111	133	32	9	13	17	59	49	0	0.308	1.000	1.000
558	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(16), BUB1B(1), BUB3(1), CCNA1(8), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(5), CDC20(1), CDC25A(1), CDC25B(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(2), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), DTX4(4), E2F1(1), E2F5(1), EP300(11), ESPL1(8), GSK3B(3), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(11), PTPRA(3), RB1(2), SKP2(1), SMAD4(1), TBC1D8(1), TP53(18), WEE1(1)	73140385	172	110	158	40	12	23	26	53	55	3	0.111	1.000	1.000
559	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(3), CREBBP(6), CTNNB1(1), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(11), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GSK3B(3), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), POMC(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), TCF7L2(1), TYR(5), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	68695131	147	110	141	33	15	14	16	69	33	0	0.139	1.000	1.000
560	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(1), CLK2(2), CLK3(1), CLK4(3), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(4), CPSF4(2), CSTF2T(1), CSTF3(4), DDX1(1), DDX20(4), DHX15(3), DHX16(1), DHX8(2), DHX9(4), DICER1(3), FUS(6), GIPC1(1), LSM7(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(3), POLR2A(8), PPM1G(1), PRPF3(2), PRPF4B(3), PRPF8(12), PSKH1(2), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(7), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(2), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(2), SUPT5H(6), TXNL4A(1), U2AF2(2), XRN2(3)	69462013	136	108	133	35	7	34	11	52	31	1	0.306	1.000	1.000
561	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), IPMK(1), ITPK1(1), ITPKA(1), ITPKB(1), MINPP1(1), MIOX(2), OCRL(2), PI4KA(9), PI4KB(3), PIK3C3(2), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PTEN(22), PTPMT1(2), SYNJ1(5), SYNJ2(6)	48426727	128	99	120	30	9	19	9	43	46	2	0.343	1.000	1.000
562	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(3), AKT3(2), CASP9(1), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NOS3(3), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKCA(2), PRKCG(2), PTGS2(4), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(1), SRC(2)	46331947	108	86	99	31	7	19	11	48	23	0	0.482	1.000	1.000
563	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(2), GAB2(1), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(1), LCP2(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCD(3), PRKCE(2), RAC1(1), RAC3(1), RAF1(1), SOS1(6), SOS2(3), SYK(1), VAV1(3), VAV2(4)	47420285	97	85	91	28	8	21	14	40	14	0	0.341	1.000	1.000
564	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA2(1), APOA5(2), AQP7(3), CPT1A(1), CPT1C(4), CPT2(1), CYP27A1(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(5), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(1), HMGCS2(1), ILK(4), LPL(2), ME1(1), MMP1(1), NR1H3(3), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(6), SORBS1(1), UBC(3), UCP1(1)	42196205	109	81	92	30	6	13	14	46	30	0	0.610	1.000	1.000
565	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(1), CSK(3), EGFR(10), F11R(1), GIT1(2), IGSF5(4), IKBKB(1), JAM3(1), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(2), PLCG2(2), PTPN11(1), PTPRZ1(10), RAC1(1), RELA(5), SRC(2), TJP1(2)	46433030	94	71	84	23	6	14	11	35	27	1	0.522	1.000	1.000
566	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNB1(3), MAP2K7(1), MAP3K1(6), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(3), PAK2(2), PRKCD(3), PRKDC(11), PSEN2(3), PTK2(1), RASA1(3), RB1(2), RELA(5), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	45462088	87	67	84	22	3	19	11	31	22	1	0.303	1.000	1.000
567	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(5), ATP4A(5), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), COX10(2), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB2(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), NDUFV2(1), NDUFV3(2), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1)	36695426	79	67	78	26	5	11	11	35	17	0	0.803	1.000	1.000
568	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(5), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(2), EP400(8), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(5), NUDT5(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(7), SMARCA2(5), SMARCA5(1)	40685480	81	67	78	23	2	19	11	21	28	0	0.438	1.000	1.000
569	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(7), AXIN1(3), CCND2(1), CTNNB1(1), DVL1(1), DVL2(1), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD5(1), GSK3B(3), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1)	37193972	72	64	69	22	6	13	7	27	19	0	0.564	1.000	1.000
570	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(4), AOC3(1), ARG1(1), ASL(4), CPS1(5), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(1), NOS1(9), NOS3(3), OAT(1), ODC1(2), OTC(1), P4HA1(3), P4HA2(1), P4HA3(1), PYCR1(1), RARS(2), SMS(2)	28582659	68	60	66	20	3	5	14	26	20	0	0.663	1.000	1.000
571	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(6), EEF1A2(1), EEF1D(1), EEF1G(1), EEF2K(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(3), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(10), PABPC3(7), PAIP1(3), SLC35A4(2)	28841964	68	60	68	23	8	11	9	24	16	0	0.712	1.000	1.000
572	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(2), MCM2(6), MCM5(2), MCM6(3), MCM7(5), NACA(10), ORC1L(1), ORC2L(1), PCNA(3), POLD1(6), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(5), RFC2(1), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBB(1), UBC(3)	33302474	72	58	64	22	5	8	7	26	26	0	0.825	1.000	1.000
573	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(2), CARS(6), CARS2(3), DARS(1), DARS2(1), EPRS(3), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(3), KARS(1), LARS(3), LARS2(2), MARS(2), MARS2(3), NARS2(4), PARS2(3), QARS(1), RARS(2), SARS(3), TARS(6), TARS2(5), VARS(2), VARS2(2), WARS(1), WARS2(4), YARS(1)	34829011	73	57	67	19	1	12	8	33	19	0	0.500	1.000	1.000
574	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(3), GAA(1), GBA3(2), GBE1(1), GPI(3), GUSB(7), GYS1(3), GYS2(1), HK1(4), MGAM(6), PYGB(2), PYGL(1), PYGM(3), RNPC3(1), SI(6), UCHL3(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1)	37840880	68	57	63	24	5	9	11	21	22	0	0.848	1.000	1.000
575	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(4), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(4), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADHA(2), MAOA(1), TPH1(1), WARS(1), WARS2(4)	35913132	73	57	66	22	6	12	8	30	17	0	0.630	1.000	1.000
576	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1C1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(2), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	38058446	69	55	65	20	7	8	9	25	20	0	0.665	1.000	1.000
577	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(3), F13B(2), F2(3), F5(8), F7(1), F8(5), F9(2), FGA(2), FGG(5), LPA(6), PLAT(4), PLAU(4), PLG(5), SERPINF2(2), VWF(11)	22827589	64	54	60	21	4	4	11	24	19	2	0.740	1.000	1.000
578	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(4), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	33048574	71	54	70	29	4	17	10	23	17	0	0.953	1.000	1.000
579	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(4), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	33048574	71	54	70	29	4	17	10	23	17	0	0.953	1.000	1.000
580	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK14(1), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SYK(1), SYT1(1), VAV1(3)	24547456	57	49	54	20	6	9	4	19	19	0	0.858	1.000	1.000
581	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(7), CREBBP(6), EP300(11), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(7), NRIP1(6), PELP1(1), POLR2A(8), SRA1(1), TBP(1)	30162873	58	49	55	16	2	7	10	22	17	0	0.476	1.000	1.000
582	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(4), ASS1(2), CPS1(5), DAO(1), EPRS(3), GATM(2), GOT1(3), GOT2(2), LAP3(2), NOS1(9), NOS3(3), OAT(1), OTC(1), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), PYCR2(1), RARS(2)	23285057	53	48	53	16	3	4	12	21	13	0	0.645	1.000	1.000
583	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), ATP8A1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR77(1), GRPR(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(3), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2), TSHR(2)	32739361	60	48	60	23	15	7	5	23	10	0	0.686	1.000	1.000
584	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(2), DGKA(2), GCA(2), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(4), PDE3B(1), PIK3C2G(3), PIK3CA(12), PIK3CD(1), PIK3R1(2)	32164513	56	48	53	15	6	12	6	23	9	0	0.260	1.000	1.000
585	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(2), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3CA(12), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCG1(2), PLCG2(2)	29634825	56	46	51	19	2	8	4	26	16	0	0.907	1.000	1.000
586	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(1), ESR2(2), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(2), NR4A2(1), NR5A2(2), PGR(2), PPARD(1), PPARG(2), RARA(4), RARB(3), RORA(2), RORC(1), RXRB(4), RXRG(2), THRA(2), VDR(1)	26236564	46	44	46	16	6	6	11	15	8	0	0.710	1.000	1.000
587	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(5), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(4)	21376454	46	43	43	18	2	6	8	19	11	0	0.919	1.000	1.000
588	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDS2(1), CHAT(4), CHKB(2), CLC(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(3), PLCB2(2), PLCG1(2), PLCG2(2), PPAP2B(1), PPAP2C(2)	32534496	49	42	45	18	6	10	4	13	16	0	0.804	1.000	1.000
589	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(3), G6PC(3), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(3), GANC(2), GLA(1), GLB1(5), HK1(4), LALBA(1), LCT(2), MGAM(6), PFKL(1), PFKM(3), PFKP(2), RDH11(3), UGP2(1)	24901001	47	41	46	14	5	6	7	14	15	0	0.624	1.000	1.000
590	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(2), ASAH1(2), GNAI1(1), GNB1(2), ITGAV(1), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLCB1(1), PRKCA(2), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2)	18022500	43	39	40	15	2	12	4	16	9	0	0.701	1.000	1.000
591	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(1), ADCY3(4), ADCY9(4), ARF1(1), ARF3(1), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ATP6V1G1(1), ERO1L(1), GNAS(4), PLCG1(2), PLCG2(2), PRKCA(2), SEC61B(1), TRIM23(3)	24292078	43	38	42	17	1	6	5	17	14	0	0.970	1.000	1.000
592	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(3), JAK1(5), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(6), SRF(1), STAT3(3)	15363821	41	38	41	13	3	4	6	18	10	0	0.815	1.000	1.000
593	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GRB2(2), HRAS(1), JUN(2), MAP2K3(3), MAP3K1(6), MAPK14(1), MAPK3(1), PAK1(2), PLCG1(2), PRKCA(2), PTK2B(3), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SRC(2), SYT1(1)	18578940	43	38	42	13	4	9	1	18	11	0	0.767	1.000	1.000
594	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(3), PIK3CA(12), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(5)	18409884	42	37	35	16	1	11	3	16	10	1	0.882	1.000	1.000
595	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(2), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(2), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS9(1)	14457472	39	35	39	10	2	3	8	19	7	0	0.501	1.000	1.000
596	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), G6PC(3), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(3), GLA(1), GLB1(5), HK1(4), LALBA(1), LCT(2), MGAM(6), PFKM(3), PFKP(2)	21050291	37	33	36	14	3	5	5	10	14	0	0.881	1.000	1.000
597	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA1(1), IL22RA2(1), JAK1(5), JAK2(5), JAK3(3), SOCS3(1), STAT1(4), STAT3(3), STAT5A(2), STAT5B(2), TYK2(6)	11937463	34	33	32	13	1	0	6	14	13	0	0.975	1.000	1.000
598	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(5), JAK3(3), JUN(2), MAPK3(1), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2), SYK(1)	15080632	35	33	34	11	4	5	4	14	8	0	0.723	1.000	1.000
599	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(4)	18605266	36	32	36	11	6	9	1	15	5	0	0.414	1.000	1.000
600	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(5), ITGB1(4), ITGB3(1), PTK2(1), PXN(1), RAC1(1), SPTAN1(6), SRC(2), TLN1(7)	18685380	35	32	34	12	3	4	1	14	13	0	0.891	1.000	1.000
601	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(14), SCARB1(2), SOAT1(4)	17613083	32	31	30	10	2	7	4	10	9	0	0.592	1.000	1.000
602	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM2(3), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2)	15949244	33	30	31	15	5	3	2	14	9	0	0.908	1.000	1.000
603	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), SLC23A1(5), SLC23A2(1), SLC2A1(1), SLC2A3(2)	16805555	30	29	30	12	3	10	2	9	6	0	0.772	1.000	1.000
604	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(4), GNB1(2), HRAS(1), LIMK1(4), MAPK3(1), MYL2(1), NOX1(6), PIK3C2G(3), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2(1), RAF1(1), ROCK2(3)	16827317	32	28	28	12	1	3	1	15	12	0	0.982	1.000	1.000
605	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(7), CD2(2), CD33(1), IFNA1(2), IFNB1(3), IL3(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(4), TLR9(1)	11884722	29	28	28	10	2	6	6	10	5	0	0.701	1.000	1.000
606	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(2), ANXA4(1), ANXA6(2), CYP11A1(1), EDNRB(3), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), PTGS1(2), PTGS2(4), TBXAS1(3)	13322619	28	28	28	16	2	4	4	10	7	1	0.983	1.000	1.000
607	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	13047876	31	27	28	11	2	5	2	7	15	0	0.901	1.000	1.000
608	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), PLA2G4A(1), PLCB1(1), PRKCA(2), PTGS1(2), PTK2(1), RAF1(1), SRC(2), SYK(1), TBXAS1(3)	16063605	31	27	30	15	2	5	3	8	12	1	0.972	1.000	1.000
609	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(2), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), REN(1)	16834151	28	26	28	11	3	10	3	7	5	0	0.685	1.000	1.000
610	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(3), CTNNA1(4), CTNNA2(5), CTNNB1(1), PTK2(1), PXN(1), SRC(2), VCL(2)	12436358	27	26	27	13	5	4	3	12	3	0	0.931	1.000	1.000
611	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(7), G6PD(2), GCLC(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(2), IDH1(2), IDH2(5)	11898082	29	26	26	11	1	2	6	12	8	0	0.937	1.000	1.000
612	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(5), GALNT2(2), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	9626314	23	22	20	14	1	1	6	6	9	0	0.997	1.000	1.000
613	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
614	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	1058489	1	1	1	2	0	0	1	0	0	0	0.982	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		341605	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000