rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(2), HRAS(1), NGFR(1), NTRK1(6), PIK3CD(1), SHC1(3), SOS1(6) 8805146 29 28 28 1 2 6 3 15 3 0 0.00479 0.0104 1.000 2 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(3), GOT2(2), TAT(1), TYR(5) 3135385 13 13 13 1 1 0 3 4 5 0 0.272 0.0105 1.000 3 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(4), EGFR(10), HGS(2), RAB5A(1), TFRC(2) 8444563 25 24 23 0 4 1 6 6 8 0 0.00377 0.0209 1.000 4 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(10), ERBB3(6), NRG1(4), UBE2D1(2) 6806238 26 26 24 3 3 2 4 9 8 0 0.140 0.0268 1.000 5 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(4), GNB1(2), PPP2CA(1), PRKAA2(4), PRKAB1(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2) 9860005 33 31 30 2 3 3 2 15 10 0 0.0263 0.0310 1.000 6 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(3), PDXP(1), PSAT1(1) 3151763 12 11 12 0 2 1 0 6 3 0 0.0789 0.0377 1.000 7 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(19), MAP2(4), PPP2CA(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAR2B(2), PRKCE(2) 12102647 39 37 36 3 5 2 2 17 12 1 0.0261 0.0395 1.000 8 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(4), CPS1(5), GLS(4), GOT1(3) 5133932 17 17 17 1 0 3 1 8 5 0 0.132 0.0395 1.000 9 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(3), MPST(2) 4479216 18 18 16 2 1 0 2 6 9 0 0.390 0.0449 1.000 10 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(10), MAP3K1(6), MAPK14(1), NCOR2(7), RARA(4), THRA(2) 11146341 34 30 32 2 2 4 7 9 12 0 0.0154 0.0567 1.000 11 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(4), TYR(5) 6283322 19 18 19 1 1 2 5 7 4 0 0.0556 0.0580 1.000 12 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(22), RANGAP1(1) 5391270 24 20 18 2 2 6 2 5 9 0 0.0533 0.0709 1.000 13 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(4), AKT1(2), ATM(16), BAX(1), CDKN1A(1), CPB2(5), CSNK1A1(2), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1) 12591479 37 32 34 2 0 4 5 13 15 0 0.0144 0.0768 1.000 14 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(2), WT1(3) 3982979 15 15 15 2 0 1 0 8 6 0 0.479 0.0900 1.000 15 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(1) 1757669 6 6 6 1 1 0 2 0 3 0 0.569 0.105 1.000 16 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ARPC1B(1), CDC42(1), PAK1(2), PDGFRA(7), PIK3R1(2), RAC1(1), WASL(6) 7083750 21 20 21 2 0 4 1 12 4 0 0.132 0.110 1.000 17 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(5), KARS(1) 3196928 9 9 9 1 0 1 1 2 5 0 0.448 0.124 1.000 18 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(4) 3459591 11 11 11 2 1 1 1 4 3 1 0.531 0.127 1.000 19 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), GNA12(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAR2B(2) 6577458 19 19 19 2 2 3 3 9 2 0 0.0991 0.143 1.000 20 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(2), AASS(5), KARS(1) 4697753 12 12 12 1 0 2 1 3 6 0 0.314 0.144 1.000 21 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 778537 4 3 4 0 0 1 1 1 1 0 0.376 0.149 1.000 22 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD2(2), CD34(2), CD3E(2), CD3G(2), CD8A(1), IL3(1), KITLG(2) 3521831 12 10 12 1 1 2 1 5 3 0 0.266 0.151 1.000 23 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), HLA-DRA(1), HLA-DRB1(1) 748139 3 3 3 0 1 0 0 0 2 0 0.699 0.158 1.000 24 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 2637325 9 9 9 2 0 1 3 2 3 0 0.523 0.158 1.000 25 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(6), EGF(4), EGFR(10), GRB2(2), MET(6), PDGFRA(7), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(1), SRC(2) 12895146 45 40 42 5 3 7 5 16 14 0 0.0416 0.173 1.000 26 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(1), GSS(1), NFKB1(1), NOX1(6), RELA(5), XDH(6) 6455005 21 18 16 1 1 2 4 5 8 1 0.0983 0.178 1.000 27 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(7), MMP9(1), RECK(1), TIMP3(4) 4896566 15 14 12 1 2 3 1 3 6 0 0.137 0.186 1.000 28 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(5), HADHA(2) 3225085 9 9 8 0 1 3 2 1 2 0 0.0459 0.187 1.000 29 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(2), JAK1(5), JAK2(5), STAT1(4) 5533825 18 18 18 3 1 0 2 10 5 0 0.492 0.194 1.000 30 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ACADS(3), ECHS1(2), HADHA(2) 3565989 8 8 7 0 3 1 3 1 0 0 0.0479 0.198 1.000 31 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(2), VNN2(1) 7846258 19 17 18 1 3 5 4 2 5 0 0.0155 0.229 1.000 32 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(4) 2902056 8 8 8 0 0 1 0 6 1 0 0.230 0.247 1.000 33 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(6), EP300(11), NCOA3(5), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RARA(4) 13385859 37 35 34 3 3 2 7 18 7 0 0.0122 0.248 1.000 34 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(4), AOC3(1), CES1(7) 3671618 17 16 15 3 0 2 2 8 5 0 0.311 0.253 1.000 35 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD28(1), CD3E(2), CD3G(2) 1554162 5 4 5 0 1 1 1 1 1 0 0.253 0.268 1.000 36 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25B(1), CDC25C(2), MNAT1(1), SHH(1), XPO1(6) 5730976 13 13 13 1 0 1 4 7 1 0 0.133 0.280 1.000 37 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(2), CD3G(2), CREBBP(6), CSK(3), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6) 13841274 40 36 40 3 4 4 2 23 7 0 0.0252 0.288 1.000 38 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(2), CD3G(2), CREBBP(6), CSK(3), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6) 13841274 40 36 40 3 4 4 2 23 7 0 0.0252 0.288 1.000 39 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(2), NDUFA13(2) 2720684 6 6 6 0 2 1 0 2 1 0 0.182 0.320 1.000 40 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), FOS(1), JUN(2), MAPK3(1), POLR2A(8), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 8295387 24 23 24 3 6 2 2 10 4 0 0.0931 0.328 1.000 41 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2) 3825796 12 11 12 2 1 3 1 6 1 0 0.241 0.329 1.000 42 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(2), GOT1(3), GOT2(2), PAH(4), TAT(1), YARS(1) 5536066 18 16 18 3 2 1 5 4 6 0 0.292 0.343 1.000 43 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(4), OAT(1), PRODH(1) 3619832 8 8 8 0 0 1 3 3 1 0 0.124 0.345 1.000 44 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS2(1), DHRSX(5), PON3(4), RDH11(3) 5824116 16 15 11 1 2 0 3 4 7 0 0.276 0.353 1.000 45 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(3), ABCB4(5), ABCC1(8), ABCC3(10) 9684385 30 23 24 3 1 4 5 9 11 0 0.0841 0.357 1.000 46 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(11) 4734833 17 15 14 3 1 2 2 7 5 0 0.524 0.360 1.000 47 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(5), GCDH(3), HADHA(2), SDHB(1) 5173720 13 13 10 0 1 3 3 1 5 0 0.0336 0.362 1.000 48 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 481049 1 1 1 0 0 0 1 0 0 0 0.751 0.362 1.000 49 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(2), GLI2(4), GLI3(5), GSK3B(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SHH(1), SMO(3), SUFU(1) 10138090 32 29 29 4 5 3 2 14 8 0 0.0855 0.373 1.000 50 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(5), HADHA(2), HADHB(3) 5572378 12 12 11 0 1 4 3 2 2 0 0.0187 0.379 1.000 51 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAP2B(2) 9420366 24 24 24 3 3 1 2 12 6 0 0.250 0.380 1.000 52 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2) 4071859 11 11 11 2 1 1 0 8 1 0 0.580 0.385 1.000 53 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(1), HRAS(1), PTK2B(3), SHC1(3), SOS1(6), SRC(2) 5690638 18 16 18 3 1 6 2 6 3 0 0.279 0.386 1.000 54 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), HLA-DRA(1), HLA-DRB1(1), IL4(1) 1810951 4 4 4 1 1 0 1 0 2 0 0.750 0.386 1.000 55 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(1), RDH11(3) 3085748 7 7 7 0 2 0 1 4 0 0 0.158 0.389 1.000 56 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(2), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(3), TOB1(2), TOB2(3) 7049851 20 19 20 3 1 3 4 7 5 0 0.217 0.405 1.000 57 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1) 6888798 14 14 14 1 1 2 1 5 5 0 0.163 0.426 1.000 58 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), IDS(2), IDUA(1), LCT(2), NAGLU(2) 9307263 26 22 24 3 4 3 4 10 5 0 0.0663 0.427 1.000 59 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(2), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PRF1(1) 5356831 14 12 14 1 1 4 2 4 3 0 0.0917 0.428 1.000 60 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), LUM(1) 2353850 7 7 7 2 0 1 0 4 2 0 0.683 0.437 1.000 61 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(6), POLG(4), PRPS2(3), RRM1(3) 8012839 20 19 18 2 2 4 1 6 7 0 0.142 0.460 1.000 62 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 ABO(1), B3GNT1(1), FUT1(1), ST8SIA1(2) 2423982 5 5 5 1 2 1 0 1 1 0 0.488 0.468 1.000 63 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG7(4), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), PIK3C3(2), PIK3R4(4), PRKAA2(4), ULK1(1), ULK2(1), ULK3(3) 13894331 33 31 30 3 2 3 2 16 10 0 0.0740 0.480 1.000 64 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(2), CD28(1), CD3E(2), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 6762553 20 18 20 3 2 3 2 9 4 0 0.255 0.482 1.000 65 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(2), CAMKK2(2), SYT1(1) 7576560 16 16 15 0 1 1 2 7 5 0 0.0480 0.486 1.000 66 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(2), AKT2(3), AKT3(2), GRB2(2), ILK(4), MAPK3(1), PDK1(1), PIK3CD(1), PTK2B(3), RBL2(2), SHC1(3), SOS1(6) 11294224 30 27 28 3 3 7 3 10 7 0 0.0562 0.492 1.000 67 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(5), GNAS(4), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 8295712 24 24 24 4 3 2 0 14 5 0 0.435 0.493 1.000 68 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(3), GPRC5A(1), GPRC5B(2), GPRC5C(1), GRM1(5), GRM2(2), GRM3(3), GRM4(3), GRM5(8), GRM7(4), GRM8(3) 12621622 40 34 37 5 5 6 3 15 11 0 0.0742 0.498 1.000 69 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 1107719 2 2 2 1 0 1 0 1 0 0 0.763 0.515 1.000 70 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(1), IKBKB(1), IL4(1), JUN(2), MAP3K1(6), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(5), TNFRSF9(1), TNFSF9(1), TRAF2(1) 13014003 31 27 28 3 0 4 1 15 10 1 0.203 0.521 1.000 71 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 1021533 2 2 2 1 0 0 0 2 0 0 0.880 0.521 1.000 72 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(2), IFNB1(3), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(3), JUN(2), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFB2(2), TGFB3(1), TRAF6(2) 19456804 45 42 41 4 4 12 0 16 12 1 0.0165 0.523 1.000 73 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(3), UXS1(1) 2648399 5 5 5 1 0 1 2 2 0 0 0.555 0.524 1.000 74 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), CPT1A(1), LEP(1), LEPR(1), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4) 9711466 21 21 18 2 1 4 4 3 9 0 0.0613 0.530 1.000 75 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 6954807 21 18 21 3 2 4 2 9 4 0 0.194 0.531 1.000 76 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(2), FSHR(2), GNAS(4), XPO1(6) 6080934 17 17 17 3 3 1 3 7 3 0 0.416 0.532 1.000 77 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(5), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 10437781 23 23 23 2 3 0 0 13 7 0 0.0853 0.534 1.000 78 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(2), NFATC2(5), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 7255388 28 27 26 5 5 0 1 15 7 0 0.268 0.534 1.000 79 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(2), EIF2S2(2), MAP3K14(1), NFKB1(1), RELA(5) 6021957 12 12 9 1 0 4 0 2 5 1 0.398 0.556 1.000 80 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(3), UGP2(1), UXS1(1) 3354142 6 6 6 1 0 1 3 2 0 0 0.434 0.559 1.000 81 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), ARF3(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(8) 4769783 24 21 16 6 0 1 3 5 15 0 0.897 0.561 1.000 82 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(4), GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 3581936 15 15 12 4 0 1 3 4 7 0 0.596 0.579 1.000 83 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(2), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(4) 7662500 20 19 20 3 1 3 4 7 5 0 0.240 0.580 1.000 84 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), IDH1(2), IDH2(5), MDH1(1), SDHB(1), SUCLA2(1) 5926418 14 13 11 2 1 2 1 5 5 0 0.368 0.582 1.000 85 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(5) 8256148 19 18 16 2 0 4 1 6 7 1 0.183 0.590 1.000 86 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(2), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(1), PTPRC(6) 5093230 14 12 14 2 0 2 1 7 4 0 0.477 0.595 1.000 87 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTR2(1), ARPC1B(1), NCK1(1), NCKAP1(2), NTRK1(6), RAC1(1), WASF2(2), WASF3(3), WASL(6) 9573330 23 23 22 3 0 4 2 14 3 0 0.208 0.598 1.000 88 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(6), NT5M(2), QPRT(1) 9614289 22 22 22 3 1 2 3 12 4 0 0.165 0.614 1.000 89 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(3), TPI1(1) 2534776 6 6 6 4 0 0 1 1 4 0 0.993 0.617 1.000 90 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(2) 2908836 6 6 6 1 0 0 0 4 2 0 0.766 0.617 1.000 91 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2) 3778160 8 8 7 2 1 0 0 5 2 0 0.801 0.621 1.000 92 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(1), CNR2(2), MTNR1B(1), PTAFR(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), TBXA2R(2) 4663794 15 15 15 4 1 2 0 7 5 0 0.598 0.627 1.000 93 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB1A(2), RAB3A(1), RAB4A(1), RAB5A(1) 2793408 5 5 5 0 1 0 1 1 2 0 0.222 0.627 1.000 94 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(3), MST1R(4) 3807978 9 9 8 2 0 1 5 1 2 0 0.562 0.630 1.000 95 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(2), IFNB1(3), JAK1(5), STAT1(4), STAT2(6), TYK2(6) 7056471 28 24 27 6 2 7 3 7 9 0 0.255 0.643 1.000 96 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 1497521 3 3 3 1 0 0 1 0 2 0 0.902 0.644 1.000 97 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(6), IL3(1), KITLG(2), TGFB2(2), TGFB3(1) 5477520 13 13 13 2 0 1 1 7 4 0 0.515 0.647 1.000 98 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), MECR(1) 5555699 10 9 10 0 1 2 4 3 0 0 0.0351 0.649 1.000 99 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1B(1), BMPR2(5) 4067154 9 7 9 0 0 1 2 4 2 0 0.0715 0.659 1.000 100 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(3), GPI(3), HK1(4), PFKL(1), PGAM1(1), PGK1(3), TPI1(1) 5888375 19 17 17 4 3 2 2 5 7 0 0.437 0.662 1.000 101 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(8), CCNE1(2), CCNE2(2), CDK2(2), CDK4(6), CDKN2A(3), E2F1(1), PRB1(8) 5784289 32 24 20 6 1 2 3 5 21 0 0.678 0.680 1.000 102 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), HLA-DRB1(1), IL3(1) 1780309 3 3 3 0 0 0 0 1 2 0 0.826 0.686 1.000 103 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTR2(1), ARPC1B(1), CDC42(1), RAC1(1), WASL(6) 4930054 10 10 10 2 0 3 0 7 0 0 0.486 0.687 1.000 104 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1) 2183565 4 4 4 1 0 0 0 2 2 0 0.892 0.696 1.000 105 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2) 8183213 18 17 18 3 4 1 1 8 4 0 0.340 0.704 1.000 106 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), CASP9(1), CHUK(1), GHR(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(5) 7868555 14 14 11 0 0 4 0 4 5 1 0.0519 0.704 1.000 107 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), NAGLU(2), SPAM1(6) 13332496 40 33 38 6 6 6 5 16 7 0 0.0439 0.707 1.000 108 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(1), GRIA2(3), PPP1R1B(1) 2312513 5 5 5 2 1 1 0 3 0 0 0.748 0.734 1.000 109 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(2), EGF(4), EGFR(10), GRB2(2), HRAS(1), MAPK3(1), PTPRB(3), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SPRY1(1), SPRY2(2), SRC(2) 16181333 41 34 39 5 4 11 6 11 9 0 0.0364 0.742 1.000 110 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1) 2735789 4 4 4 1 0 1 1 0 2 0 0.815 0.745 1.000 111 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SCLY(2), SEPHS1(1) 7909012 17 17 17 3 2 0 6 5 4 0 0.284 0.755 1.000 112 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(1) 2545277 3 3 3 1 0 0 2 0 1 0 0.770 0.757 1.000 113 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 HLA-DRA(1), HLA-DRB1(1), IFNA1(2), IFNB1(3), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1) 7760287 14 14 14 2 0 5 1 6 2 0 0.198 0.762 1.000 114 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1070228 1 1 1 0 0 0 0 1 0 0 0.838 0.763 1.000 115 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(5), JAK2(5), PTPRU(5), STAT1(4) 7501440 21 19 21 4 2 0 2 13 4 0 0.473 0.765 1.000 116 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(4), GNB1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2) 6151940 19 18 19 4 2 2 0 12 3 0 0.546 0.767 1.000 117 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(2), CD86(1), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), PIK3R1(2), PTPN11(1) 6845113 18 17 17 3 1 4 1 4 8 0 0.536 0.767 1.000 118 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1) 6720053 14 12 14 2 0 3 2 5 4 0 0.266 0.768 1.000 119 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), NDST1(2), NDST2(3), NDST4(5) 13199599 33 31 27 3 2 4 5 9 13 0 0.0392 0.770 1.000 120 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(5), TNFRSF13B(1), TNFRSF17(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2) 9546530 18 17 15 2 0 4 0 7 6 1 0.363 0.773 1.000 121 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), STX1A(1), VAMP2(1) 2113258 5 5 5 3 0 0 0 2 3 0 0.972 0.775 1.000 122 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), GBA3(2), MPO(4), TPO(4) 5410392 14 13 14 3 1 2 4 5 2 0 0.390 0.776 1.000 123 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(1), FUT6(2), ST3GAL3(3) 2932945 7 7 6 2 2 1 0 0 4 0 0.785 0.782 1.000 124 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(2), IFNB1(3), NFKB1(1), RELA(5), TRAF6(2) 7067516 14 14 11 2 1 6 0 1 5 1 0.361 0.785 1.000 125 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD2(1), GGT1(2) 3696433 5 5 5 1 0 1 2 1 1 0 0.469 0.785 1.000 126 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(2) 3173931 4 4 4 0 1 0 1 0 2 0 0.468 0.791 1.000 127 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 1344260 3 3 3 2 0 2 0 1 0 0 0.868 0.791 1.000 128 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2) 8545476 21 20 19 3 1 4 4 4 8 0 0.173 0.798 1.000 129 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(7), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 9718536 24 23 24 4 2 2 1 12 7 0 0.408 0.806 1.000 130 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2) 10831774 20 19 16 1 1 1 3 7 8 0 0.150 0.815 1.000 131 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1) 5329177 7 7 7 1 1 1 3 2 0 0 0.321 0.822 1.000 132 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(5), ACADM(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), CNDP1(4), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(2) 17467757 47 41 44 7 3 6 12 13 13 0 0.0355 0.829 1.000 133 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(6), FADS2(2), FASN(3), HADHA(2), PECR(1) 9051181 18 17 15 3 3 2 4 5 4 0 0.169 0.830 1.000 134 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(5), AOC2(4), AOC3(1), CES1(7), DDHD1(2), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PLA1A(3), PNPLA3(2), SH3GLB1(2) 16430976 37 32 35 3 2 3 4 17 11 0 0.0365 0.831 1.000 135 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(3), FUT1(1), FUT6(2), ST3GAL6(1), ST8SIA1(2) 8299108 18 17 18 3 3 4 2 3 6 0 0.289 0.842 1.000 136 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2) 2037938 2 2 2 0 0 1 0 1 0 0 0.551 0.848 1.000 137 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(7), RPE(1), UCHL3(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 11577235 27 23 25 4 2 5 4 6 10 0 0.192 0.849 1.000 138 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(2), FDPS(1), IDI1(1), LSS(2), MVK(1), PMVK(1), SC5DL(1), VKORC1(1) 7266876 12 12 12 1 0 0 1 8 3 0 0.408 0.850 1.000 139 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(3), GPR75(1) 6370681 10 10 10 2 1 2 0 4 2 1 0.190 0.852 1.000 140 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(4), EIF2B5(2), EIF2S2(2), EIF5(2), GSK3B(3) 7634764 16 15 14 2 1 1 2 4 8 0 0.359 0.853 1.000 141 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(3), CASP8(1), CASP9(1), JUN(2), PRF1(1) 8351688 17 16 17 3 0 3 1 8 5 0 0.446 0.853 1.000 142 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(2), IL4(1), IL4R(2), IRS1(4), JAK1(5), JAK3(3), RPS6KB1(2), SHC1(3), STAT6(4) 9209886 28 26 28 5 4 3 4 10 7 0 0.248 0.859 1.000 143 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1) 8767774 18 18 18 3 0 1 2 8 7 0 0.536 0.865 1.000 144 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(5), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP2K6(1), MAP3K1(6), MAP3K5(5), MAP3K7(1), MAP3K9(4), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(1), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), RPS6KA5(1), SHC1(3), STAT1(4), TGFB2(2), TGFB3(1), TRADD(2), TRAF2(1) 24138594 60 52 58 7 6 5 3 31 15 0 0.0268 0.874 1.000 145 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(2), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(2), HRAS(1), MAPK14(1), MAPK3(1), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAC1(1), RPS6KA1(7), RPS6KA5(1), SOS1(6) 17474901 48 46 44 7 5 7 2 24 9 1 0.150 0.875 1.000 146 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(2), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAPK14(1), MAPK3(1), NFKB1(1), PIK3R1(2), RB1(2), RELA(5), SP1(2) 11540591 26 25 23 4 2 6 0 10 7 1 0.255 0.879 1.000 147 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(1), AKR1B10(3), ALAS1(5), ALAS2(3), AOC2(4), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(5), GATM(2), GLDC(3), GNMT(2), MAOA(1), PHGDH(3), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(4), SARS(3), SHMT1(2), SHMT2(3), TARS(6), TARS2(5) 27800539 78 67 74 11 10 12 13 27 16 0 0.00377 0.880 1.000 148 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(1), NEK1(3), WEE1(1) 4906037 7 6 7 1 0 2 0 3 2 0 0.447 0.880 1.000 149 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDFT1(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1) 8670732 16 14 16 1 0 2 1 8 5 0 0.213 0.882 1.000 150 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(1), C1R(3), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1) 10533806 22 21 22 4 3 4 1 10 4 0 0.241 0.884 1.000 151 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(5), F13A1(1), F2(3), FGA(2), FGG(5), PLAT(4), PLAU(4), PLG(5) 8931892 29 27 24 6 1 1 4 13 10 0 0.413 0.895 1.000 152 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(11), LPL(2), NCOA1(3), NCOA2(9), PPARG(2) 12108595 33 24 24 4 3 3 4 9 14 0 0.0681 0.896 1.000 153 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(5), C6(1), C7(3), C8A(1) 8544986 16 16 16 3 2 2 1 8 3 0 0.325 0.897 1.000 154 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3) 9596586 18 17 14 1 1 2 2 5 8 0 0.213 0.899 1.000 155 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(1), CDC25C(2), CSK(3), GRB2(2), PRKCA(2), PTPRA(3), SRC(2) 6030235 16 14 16 4 0 6 1 6 3 0 0.418 0.899 1.000 156 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 1350624 1 1 1 1 0 0 0 1 0 0 0.940 0.901 1.000 157 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(3), PPP2CA(1) 6119567 11 10 9 0 0 1 1 1 8 0 0.108 0.908 1.000 158 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(3), HDAC9(2), MEF2A(1), MEF2D(1) 5358220 8 8 7 1 1 0 0 2 5 0 0.614 0.909 1.000 159 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), CREBBP(6), DFFB(1), PRF1(1) 6823412 10 9 10 0 2 2 2 3 1 0 0.0518 0.912 1.000 160 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1), SPCS1(1) 2028703 2 2 2 1 0 0 0 2 0 0 0.869 0.912 1.000 161 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), NFS1(2), THTPA(1), TPK1(1) 4262104 6 6 6 2 2 0 1 3 0 0 0.691 0.913 1.000 162 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(3), CPOX(6), FECH(2), PPOX(1), UROD(1) 5062066 18 18 13 6 0 0 3 7 8 0 0.870 0.918 1.000 163 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(3), JAK1(5), PTPRU(5), STAT1(4), STAT2(6), TYK2(6) 8016205 31 27 30 7 3 5 3 11 9 0 0.320 0.918 1.000 164 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(2), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), YOD1(1) 16967600 35 31 28 3 2 4 6 8 15 0 0.0748 0.922 1.000 165 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(7), AXIN1(3), BTRC(2), CREBBP(6), CSNK1A1(2), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(4) 18971371 42 37 36 4 3 3 5 17 14 0 0.0218 0.923 1.000 166 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(4) 7542016 19 18 19 4 1 3 3 7 5 0 0.440 0.927 1.000 167 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(8), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(2), SKP2(1) 5788222 19 18 16 5 1 3 2 3 10 0 0.576 0.929 1.000 168 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(1), PER1(5) 5502413 9 9 8 2 0 0 2 3 3 1 0.634 0.929 1.000 169 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), MAP3K14(1), NFKB1(1), RELA(5), TRAF3(1), TRAF6(2) 12025983 20 18 17 2 0 5 0 4 10 1 0.246 0.930 1.000 170 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(5), ACO1(4), ACSS1(3), ACSS2(7), IDH1(2), IDH2(5), MDH1(1), SUCLA2(1) 8812773 28 23 24 5 1 5 3 8 10 1 0.361 0.932 1.000 171 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(1), TOP2A(4), TOP2B(2) 6729138 8 8 8 0 2 1 0 3 2 0 0.206 0.933 1.000 172 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1) 15491738 36 33 33 4 1 5 3 16 11 0 0.0747 0.933 1.000 173 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(1), ST3GAL3(3), ST3GAL4(1) 4537861 11 10 10 4 2 0 1 1 7 0 0.895 0.934 1.000 174 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(2), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 5178481 9 9 9 3 0 3 3 2 1 0 0.572 0.935 1.000 175 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1) 5547482 12 12 12 3 0 1 1 5 5 0 0.807 0.936 1.000 176 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(2), SLC18A3(1) 4258777 10 10 8 3 0 2 0 2 6 0 0.887 0.938 1.000 177 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(2) 2542945 4 4 4 2 0 0 2 1 1 0 0.861 0.941 1.000 178 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2A(1), MEF2D(1), PPP3CA(2), PPP3CC(3), SLC2A4(1), SYT1(1) 13416740 20 20 19 1 2 1 1 7 9 0 0.0864 0.942 1.000 179 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCR(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAP3K1(6), MAPK3(1), MYC(1), PIK3R1(2), RAF1(1), SOS1(6), STAT1(4), STAT5A(2), STAT5B(2) 16651053 39 39 38 6 3 5 3 22 6 0 0.145 0.944 1.000 180 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(2), CASP9(1), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3R1(2), RAC1(1), RAF1(1), RALA(2), RALBP1(1), RELA(5) 11107607 21 21 17 3 1 5 0 7 7 1 0.361 0.950 1.000 181 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 EGF(4), EGFR(10), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(5), JUN(2), MAP3K1(6), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1), STAT1(4), STAT3(3), STAT5A(2) 23159982 62 56 58 10 6 9 5 22 20 0 0.165 0.952 1.000 182 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), DHCR7(2), FDFT1(2), FDPS(1), GGCX(1), IDI1(1), IDI2(2), LSS(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1), VKORC1(1) 12617987 23 21 21 2 0 2 1 11 9 0 0.266 0.957 1.000 183 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(2), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(2), PPP3CC(3), SYNJ1(5), SYNJ2(6), SYT1(1) 14557266 31 31 29 5 1 6 1 16 7 0 0.208 0.957 1.000 184 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), LCMT2(3), PCYT1A(1), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3) 9072873 16 15 16 2 1 2 1 7 5 0 0.438 0.959 1.000 185 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 2272771 1 1 1 1 0 0 0 0 1 0 0.967 0.959 1.000 186 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), NDUFA1(1), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1) 4300772 7 6 7 2 1 2 1 3 0 0 0.532 0.960 1.000 187 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(2), AKT2(3), AKT3(2), BRAF(2), EIF4B(3), FIGF(2), HIF1A(3), MAPK3(1), PGF(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRKAA2(4), RHEB(4), RICTOR(4), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(1), TSC1(2), TSC2(6), ULK1(1), ULK2(1), ULK3(3), VEGFC(2) 33073805 74 67 62 8 7 9 7 27 22 2 0.00833 0.962 1.000 188 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 24 AKT1(2), AKT2(3), AKT3(2), GRB2(2), GSK3A(2), GSK3B(3), IL4R(2), IRS1(4), JAK1(5), JAK3(3), MAP4K1(2), MAPK3(1), PDK1(1), PIK3CD(1), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(6), SOS2(3), STAT6(4) 21362212 55 47 53 9 6 9 8 21 11 0 0.0543 0.963 1.000 189 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(4) 4078790 10 10 10 3 1 0 4 2 3 0 0.657 0.964 1.000 190 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(1), CD28(1), CXCR4(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1) 12567307 18 17 18 2 4 1 2 9 2 0 0.120 0.965 1.000 191 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), PPARG(2), RETN(1) 3623001 5 5 5 2 1 2 0 1 1 0 0.732 0.965 1.000 192 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(2), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RPS6KA1(7), SRC(2) 13011651 35 33 31 6 5 3 0 19 7 1 0.292 0.966 1.000 193 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(6), DAXX(5), HRAS(1), PAX3(1), PML(5), RARA(4), RB1(2), SIRT1(4), SP100(1), TNFRSF1A(1) 11448480 30 29 30 6 4 4 5 12 5 0 0.262 0.968 1.000 194 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(2), TPH1(1) 3765718 5 5 5 2 1 1 1 1 1 0 0.762 0.969 1.000 195 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), CLTB(1), COPA(6), GBF1(7), GPLD1(1), KDELR2(2), KDELR3(2) 10825705 26 25 26 5 1 1 4 12 7 1 0.458 0.970 1.000 196 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(7), FYN(2), LRP8(4), RELN(5), VLDLR(2) 9287001 20 19 15 3 1 4 0 5 10 0 0.612 0.970 1.000 197 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2) 5551696 11 11 9 3 0 2 0 3 6 0 0.823 0.971 1.000 198 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(5), JAK2(5), TYK2(6) 6769437 19 19 18 5 1 0 3 7 8 0 0.803 0.972 1.000 199 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(5), JAK2(5), TYK2(6) 6769437 19 19 18 5 1 0 3 7 8 0 0.803 0.972 1.000 200 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), DDC(2), EPX(2), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TAT(1), TPO(4) 14132890 39 33 36 6 3 4 9 11 12 0 0.127 0.974 1.000 201 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 CHST11(1), CHST12(2), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(4) 5671732 14 14 14 4 2 1 4 2 5 0 0.709 0.976 1.000 202 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(7), EIF4E(1), FBL(1), GPT(2), LDHB(1), LDHC(3), MAPK14(1), NCL(4) 5863439 20 18 19 6 0 0 5 8 7 0 0.854 0.977 1.000 203 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2) 16469964 31 27 26 4 2 2 3 13 11 0 0.313 0.977 1.000 204 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(3), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1) 6394068 13 13 13 4 0 6 1 6 0 0 0.445 0.978 1.000 205 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK1G(3), CAMK4(1), CREBBP(6), CSNK1A1(2), ELSPBP1(1), F2(3), FGF2(1), GATA4(2), GSK3B(3), HRAS(1), MAPK14(1), MAPK3(1), MYH2(9), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NPPA(1), PIK3R1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAF1(1), RPS6KB1(2), SYT1(1) 31082128 78 65 73 9 7 8 5 28 30 0 0.0111 0.978 1.000 206 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(2), CASP9(1), DAXX(5), FAS(1), FASLG(1), HSPB2(2), MAPKAPK2(1) 7180948 13 13 13 3 2 1 1 7 2 0 0.502 0.978 1.000 207 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(2), LTA4H(4), PLA2G6(3), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(4), TBXAS1(3) 9760650 27 24 24 6 2 4 6 7 7 1 0.355 0.979 1.000 208 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), ATIC(2), FTCD(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3) 12548008 22 21 22 4 3 4 0 10 5 0 0.301 0.979 1.000 209 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(4), AOC3(1), CNDP1(4), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(2) 18839524 48 42 45 9 3 6 13 14 12 0 0.0912 0.979 1.000 210 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(1), AGTR1(2), BDKRB2(1), KNG1(2), NOS3(3), REN(1) 6220091 15 14 13 4 1 3 2 4 5 0 0.599 0.979 1.000 211 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), ASPA(1), CNDP1(4), DDC(2), HAL(1), HARS(1), HNMT(1), MAOA(1), PRPS1(1), PRPS2(3) 15828919 40 37 37 7 2 7 7 14 10 0 0.119 0.979 1.000 212 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), CAPN2(2), EGF(4), EGFR(10), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTK2(1), PXN(1), TLN1(7) 21454073 54 48 51 9 8 4 4 22 16 0 0.163 0.979 1.000 213 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2C1(5), MANBA(1), NEU1(1) 10318615 19 18 19 4 2 3 2 10 2 0 0.366 0.979 1.000 214 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1), TUB(2) 4682284 6 6 6 2 0 0 0 5 1 0 0.802 0.980 1.000 215 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(2), RB1(2) 5632778 12 11 12 5 1 2 1 2 6 0 0.880 0.981 1.000 216 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), NEDD8(2), RB1(2), SKP2(1) 5746773 13 12 12 4 1 2 1 2 7 0 0.779 0.981 1.000 217 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(2), ATM(16), BAX(1), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), PCNA(3), RB1(2), TIMP3(4) 11513444 40 31 34 8 1 4 5 9 21 0 0.573 0.982 1.000 218 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT3(2), B4GALT5(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1) 5027823 9 9 8 6 1 0 1 1 6 0 0.984 0.982 1.000 219 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(5), CS(2), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A11(1) 6003931 14 14 14 4 1 3 0 6 4 0 0.566 0.982 1.000 220 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(2), JAK1(5), STAT1(4), STAT3(3), STAT5A(2) 7906947 17 17 16 4 1 0 1 7 8 0 0.826 0.983 1.000 221 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(6), MYC(1), NFATC1(2), NFATC2(5), NFKB1(1), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), SYT1(1) 17766085 43 39 37 6 4 5 0 16 17 1 0.166 0.983 1.000 222 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2) 11441752 29 27 28 5 4 3 4 12 6 0 0.261 0.985 1.000 223 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), FAH(1), GOT1(3), GOT2(2), HGD(2), MAOA(1), TAT(1), TH(2), TPO(4), TYR(5) 20485286 62 53 58 12 5 5 8 24 20 0 0.291 0.985 1.000 224 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), LDLR(1), LPL(2) 3413036 4 4 4 2 0 3 0 1 0 0 0.732 0.986 1.000 225 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), ATIC(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3) 11867713 20 19 20 4 3 4 0 8 5 0 0.359 0.986 1.000 226 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6814216 11 11 11 3 3 2 1 5 0 0 0.388 0.987 1.000 227 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(2), GRB2(2), HRAS(1), MAPK3(1), MAPK7(1), MEF2A(1), MEF2D(1), NTRK1(6), PIK3R1(2), PLCG1(2), RPS6KA1(7), SHC1(3) 10954524 29 26 23 5 4 3 1 10 10 1 0.450 0.988 1.000 228 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAX(1), BCL10(1), BID(1), CASP8AP2(4), CASP9(1), CES1(7) 7571865 17 17 15 5 0 1 0 7 9 0 0.887 0.988 1.000 229 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(6), GRIN2B(6), NOS1(9), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), SYT1(1) 16559708 44 39 43 9 7 8 1 22 6 0 0.166 0.988 1.000 230 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(4), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(6), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKG1(3), PRKG2(2) 20348083 43 40 40 6 5 5 3 20 10 0 0.124 0.989 1.000 231 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1) 7034714 11 11 11 3 0 3 2 3 3 0 0.614 0.989 1.000 232 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(1), PRKCA(2), RELA(5) 5442041 9 9 6 4 0 3 0 0 5 1 0.927 0.989 1.000 233 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), ITPKA(1), ITPKB(1) 3678919 4 4 4 2 1 1 0 1 1 0 0.822 0.989 1.000 234 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(3), NR1H4(2) 3365546 6 6 6 3 0 3 0 3 0 0 0.802 0.990 1.000 235 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1) 4396277 5 5 5 2 0 0 1 4 0 0 0.741 0.990 1.000 236 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(1), ITGAL(5), ITGAM(5), ITGB2(1), SELE(5) 6986089 19 19 19 5 1 6 3 4 5 0 0.400 0.990 1.000 237 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(1), C1R(3), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1), C8B(2), MASP1(2) 12731512 26 25 26 5 6 4 1 11 4 0 0.189 0.990 1.000 238 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV1(1), NDUFV2(1) 4638002 12 12 12 4 0 1 1 7 3 0 0.873 0.990 1.000 239 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(1), C1R(3), C2(2), C3(6), C5(5), C6(1), C7(3), C8A(1), MASP1(2), MASP2(1), MBL2(1) 13079129 26 25 26 5 5 5 1 11 4 0 0.179 0.991 1.000 240 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(3), PKM2(1), RPE(1), TKT(1), TPI1(1) 11637287 28 26 28 6 0 3 5 8 12 0 0.491 0.992 1.000 241 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(2), SULT1C4(1), SULT4A1(1) 8238711 26 26 24 6 2 1 2 10 11 0 0.742 0.992 1.000 242 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2) 19637784 29 28 29 3 5 5 1 14 4 0 0.0234 0.992 1.000 243 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(1), CDC25B(1), CDC25C(2), MYT1(2), WEE1(1) 9173713 23 20 23 5 0 3 3 10 7 0 0.495 0.992 1.000 244 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(5), JAK2(5), JAK3(3), MAPK3(1), STAT3(3), TYK2(6) 7595297 23 23 22 9 1 0 4 9 9 0 0.953 0.992 1.000 245 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8) 10720371 25 22 23 4 2 0 0 11 12 0 0.531 0.993 1.000 246 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(7), RPE(1), UGP2(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), XYLB(1) 17938184 41 36 39 7 3 6 7 13 12 0 0.174 0.993 1.000 247 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(3), B3GNT7(1), B4GALT3(2), B4GALT4(3), CHST1(2), CHST2(1), CHST4(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1) 7451397 19 18 18 6 1 3 2 3 10 0 0.790 0.993 1.000 248 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(3), GOT2(2), PAH(4), TAT(1), YARS(1) 5743651 12 12 12 4 1 0 3 3 5 0 0.826 0.993 1.000 249 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELE(5) 8049451 20 19 20 5 1 5 4 5 5 0 0.436 0.994 1.000 250 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD8A(1), IL3(1), IL4(1) 3292154 3 3 3 2 0 1 1 1 0 0 0.893 0.994 1.000 251 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(7), CDC25C(2), CHEK2(1) 10191584 26 23 26 6 0 3 3 11 9 0 0.652 0.994 1.000 252 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(6), IRS1(4), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SLC2A4(1), SOS1(6), SRF(1) 14776831 36 33 34 7 5 9 3 13 6 0 0.190 0.994 1.000 253 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(1), LTA(1), MAP3K1(6), MAP3K14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TRAF2(1), TRAF3(1) 14638426 22 19 19 3 1 4 0 6 10 1 0.309 0.995 1.000 254 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(4), AOC3(1), ASPA(1), CNDP1(4), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HNMT(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(1) 25522496 56 48 53 7 3 11 8 20 14 0 0.0170 0.995 1.000 255 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(16), CDC25A(1), CDC25B(1), CDC25C(2), CDK2(2), CDK4(6), MYT1(2), RB1(2), WEE1(1) 11233597 33 29 30 9 0 4 5 11 13 0 0.728 0.995 1.000 256 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(16), BMPR1B(1), CCND2(1), CDK4(6), ESR2(2), FSHR(2), GJA4(1), MLH1(2), NCOR1(4), NRIP1(6), PGR(2), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(2) 21718234 50 43 47 7 3 7 7 16 17 0 0.0638 0.995 1.000 257 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(2), PRKCA(2), PTK2B(3) 4390874 8 8 7 6 0 3 0 1 4 0 0.988 0.995 1.000 258 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(2), SP1(2), SP3(2) 4473590 8 8 8 3 0 2 0 2 4 0 0.894 0.996 1.000 259 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(5), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), DDC(2), EPX(2), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), TAT(1), TPO(4) 22080165 51 44 48 7 4 5 10 17 15 0 0.0641 0.996 1.000 260 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(1), PER1(5), PER2(4), PER3(3) 11025602 16 16 14 3 0 1 4 6 4 1 0.404 0.996 1.000 261 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(5), JAK2(5), JAK3(3), PIAS1(4), PIAS3(2), PTPRU(5), SOAT1(4) 8989340 28 24 26 6 1 2 5 11 9 0 0.401 0.996 1.000 262 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(2), CREBBP(6), EP300(11), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1) 16947697 33 31 30 5 2 3 7 14 7 0 0.101 0.996 1.000 263 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F5(8), F7(1), FGA(2), FGG(5), PROC(4), PROS1(4), TFPI(1) 10725276 28 27 26 7 1 3 1 12 10 1 0.649 0.997 1.000 264 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(2), QPRT(1) 14178712 29 28 29 6 1 3 4 14 7 0 0.380 0.997 1.000 265 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(5), JUN(2), MAP3K1(6), MAPK3(1), PDGFRA(7), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1), STAT1(4), STAT3(3), STAT5A(2) 21480000 55 51 53 10 4 8 3 23 17 0 0.253 0.997 1.000 266 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NEU1(1) 12702405 21 19 21 4 2 3 3 11 2 0 0.276 0.997 1.000 267 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3), UROD(1) 5212363 16 16 14 5 0 1 3 9 3 0 0.698 0.997 1.000 268 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(6), DDX20(4), E2F1(1), ETS1(1), ETS2(1), FOS(1), HRAS(1), JUN(2), NCOR2(7), RBL2(2), SIN3A(1), SIN3B(1) 16981032 28 26 28 4 2 3 2 12 9 0 0.201 0.997 1.000 269 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(5), CDKN2A(3), E2F1(1), MYC(1), PIK3R1(2), POLR1A(4), POLR1B(2), POLR1C(3), RAC1(1), RB1(2) 10911080 24 24 23 5 1 6 0 11 6 0 0.350 0.997 1.000 270 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), HADHA(2) 7977735 19 19 16 5 1 4 3 5 6 0 0.558 0.997 1.000 271 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 DPM2(1), HRAS(1), KLK2(1), MAPK3(1), NGFR(1), RAF1(1) 4559693 6 6 6 3 1 1 0 4 0 0 0.849 0.997 1.000 272 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(1), CHUK(1), IKBKB(1), JUN(2), LTA(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 15660452 33 30 30 6 2 4 2 14 10 1 0.437 0.997 1.000 273 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(3), NOTCH1(5) 5218392 9 9 7 3 1 1 0 3 4 0 0.883 0.997 1.000 274 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(2), BCAR1(3), GRB2(2), ILK(4), ITGB1(4), MAPK3(1), PDK2(2), PIK3R1(2), PTK2(1), SHC1(3), SOS1(6) 10532557 30 24 28 6 2 5 2 12 9 0 0.539 0.997 1.000 275 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(10), ELK1(1), GNAS(4), GNB1(2), GRB2(2), HRAS(1), IGF1R(1), ITGB1(4), KLK2(1), MAPK3(1), MKNK1(2), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(4), RAF1(1), RPS6KA1(7), RPS6KA5(1), SHC1(3), SOS1(6), SRC(2), STAT3(3) 21388019 68 56 62 14 7 11 6 26 17 1 0.264 0.998 1.000 276 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), BCKDHA(1), ECHS1(2), EHHADH(5), HADHA(2), HADHB(3), HIBADH(1), IVD(2), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3) 23862148 52 50 48 9 3 8 10 18 13 0 0.138 0.998 1.000 277 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(5), C6(1), C7(3), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELP(2), SELPLG(2), VCAM1(3) 16371292 35 33 35 8 4 5 5 15 6 0 0.283 0.998 1.000 278 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(2), CD3E(2), CD3G(2), IL12RB1(2), IL12RB2(2), JAK2(5), STAT4(1), TYK2(6) 9065761 22 21 21 5 2 1 3 9 7 0 0.617 0.998 1.000 279 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(3), GRB2(2), GSK3A(2), GSK3B(3), IARS(4), INPP5D(2), PDK1(1), PPP1R13B(3), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(6), SOS2(3), TEC(6), YWHAE(1) 21613744 57 47 51 10 2 10 6 20 18 1 0.206 0.998 1.000 280 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CFL1(1), CHN1(2), LIMK1(4), MAP3K1(6), MYL2(1), MYLK(4), NCF2(1), PAK1(2), PDGFRA(7), PIK3R1(2), PLD1(3), PPP1R12B(1), RAC1(1), RALBP1(1), RPS6KB1(2), TRIO(2), VAV1(3) 21684207 44 41 42 6 1 3 2 20 18 0 0.210 0.998 1.000 281 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(6), TAF13(1), TAF1L(7), TAF2(5), TAF4(5), TAF4B(5), TAF5(2), TAF5L(2), TAF6(1), TAF7(1), TAF7L(5), TAF9B(1) 23845446 57 50 53 9 4 7 6 23 17 0 0.0784 0.998 1.000 282 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(8), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(2) 10455994 29 25 23 8 1 3 3 7 15 0 0.733 0.998 1.000 283 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(3), NAT1(1), NAT2(2), XDH(6) 5170152 15 15 15 5 2 1 3 5 4 0 0.790 0.998 1.000 284 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(3), PKM2(1), RPE(1), TKT(1), TKTL1(1), TKTL2(3), TPI1(1) 13036866 30 29 30 7 0 2 5 10 13 0 0.613 0.998 1.000 285 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 5203296 10 10 8 5 0 1 1 4 4 0 0.971 0.998 1.000 286 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 5203296 10 10 8 5 0 1 1 4 4 0 0.971 0.998 1.000 287 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA2B(1), P2RY1(1), P2RY2(1) 3573278 4 4 4 5 0 1 0 2 1 0 0.974 0.998 1.000 288 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(2), AKT2(3), AKT3(2), BRD4(5), CBL(2), CDC42(1), CDKN2A(3), F2RL2(1), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), LNPEP(3), MAPK3(1), PARD3(5), PDK1(1), PIK3CD(1), PIK3R1(2), PTPN1(1), RAF1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(3), YWHAE(1) 35358027 74 62 66 9 6 9 11 25 22 1 0.0220 0.998 1.000 289 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP19(1), SRP68(2), SRP72(2), SRP9(1) 5035886 8 8 8 3 0 3 1 4 0 0 0.701 0.998 1.000 290 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(4), AKT1(2), AKT2(3), AKT3(2), APAF1(2), ATM(16), BAX(1), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CAPN2(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(1), DFFB(1), FAS(1), FASLG(1), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(3), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), NTRK1(6), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), RIPK1(1), TNFRSF10C(1), TNFRSF1A(1), TNFSF10(6), TRADD(2), TRAF2(1) 52701715 126 101 117 18 9 16 15 53 32 1 0.00802 0.998 1.000 291 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SCLY(2), SEPHS1(1), SEPHS2(2) 15925758 31 30 31 5 3 2 9 10 7 0 0.182 0.998 1.000 292 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(6), EP300(11), IKBKB(1), NFKB1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF6(2) 14388684 31 27 25 5 1 5 6 6 12 1 0.238 0.999 1.000 293 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACADS(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), BCKDHA(1), DLD(2), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(2), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3) 28556934 58 56 54 9 4 8 12 20 14 0 0.0648 0.999 1.000 294 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(5) 6339264 12 12 12 5 0 3 0 6 3 0 0.865 0.999 1.000 295 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(6) 7505675 13 13 13 4 1 3 2 2 5 0 0.681 0.999 1.000 296 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GPX1(1), PRKCE(2) 5231754 10 10 10 5 0 0 1 7 2 0 0.955 0.999 1.000 297 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), IFNGR1(2), IFNGR2(2), IKBKB(1), JAK2(5), NFKB1(1), RB1(2), RELA(5), TNFRSF1A(1), USH1C(3), WT1(3) 11175025 26 25 23 9 0 4 2 8 11 1 0.929 0.999 1.000 298 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(2), CHST14(1), CHST7(1), CHSY1(9), DSE(1), XYLT1(2), XYLT2(2) 7901368 23 21 17 6 2 5 0 6 10 0 0.592 0.999 1.000 299 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), IDH2(5), MDH1(1), OGDH(3), SDHA(1), SUCLA2(1) 6227804 13 12 10 5 0 3 0 5 5 0 0.906 0.999 1.000 300 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), PRKCA(2) 3139352 3 3 3 3 0 1 0 1 1 0 0.980 0.999 1.000 301 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), DFFB(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(6) 11618458 24 23 24 5 1 5 3 8 7 0 0.368 0.999 1.000 302 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(2), ITGB1(4), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(2), PIK3R1(2), PTK2B(3), PTPN6(3), RAC1(1), SYK(1), VAV1(3) 10822179 28 24 27 8 2 5 3 7 11 0 0.725 0.999 1.000 303 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1) 8806978 18 18 15 5 1 1 0 9 7 0 0.862 0.999 1.000 304 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(9), FLT4(7), KDR(5), NOS3(3), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKG1(3), PRKG2(2), RYR2(11), SLC7A1(1), SYT1(1), TNNI1(1) 26966845 67 63 67 12 11 10 7 28 11 0 0.0519 0.999 1.000 305 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 30 AADAT(1), AASDH(3), AASDHPPT(2), AASS(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(4), GCDH(3), HADHA(2), PLOD1(3), PLOD2(4), SHMT1(2), SHMT2(3), TMLHE(1) 22452289 57 50 51 11 4 9 6 16 22 0 0.222 0.999 1.000 306 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(3), NPPA(1), PIK3R1(2), RELA(5), SYT1(1) 10055532 24 23 21 5 1 6 1 9 6 1 0.553 0.999 1.000 307 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(5), LCT(2), MPI(2), PYGL(1), PYGM(3), TPI1(1) 8882163 18 17 18 5 4 0 4 7 3 0 0.510 0.999 1.000 308 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(1), MAP3K1(6), MAPK3(1), NFKB1(1), NSMAF(4), RAF1(1), RELA(5), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 13355727 26 23 23 5 1 5 3 6 10 1 0.267 0.999 1.000 309 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2) 3499094 8 8 8 5 0 2 1 4 1 0 0.829 0.999 1.000 310 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(2), PLCB1(1), PLCG1(2), PRKCA(2), VAV1(3) 7083136 12 12 11 9 1 3 1 2 5 0 0.987 0.999 1.000 311 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), DHRSX(5), PON3(4) 11460846 26 25 21 6 1 5 2 9 9 0 0.525 0.999 1.000 312 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(2), APC(7), AR(1), ASAH1(2), BRAF(2), EGFR(10), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CD(1), PIK3R1(2), PITX2(2), RAF1(1), SRC(2) 33421668 62 48 60 9 8 12 10 23 8 1 0.00955 0.999 1.000 313 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(16), ATR(7), BRCA1(7), CDC25A(1), CDC25B(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(11), MYT1(2), PRKDC(11), RPS6KA1(7), WEE1(1) 27946212 68 55 61 10 1 8 8 31 19 1 0.0823 0.999 1.000 314 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(2), ASPH(3), COPS5(1), EP300(11), HIF1A(3), JUN(2), NOS3(3) 10894418 25 23 22 9 0 0 5 10 10 0 0.849 0.999 1.000 315 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 15 AHCY(1), BHMT(2), CTH(1), DNMT3B(1), MARS(2), MARS2(3), MTAP(2), TAT(1) 10261299 13 13 13 3 2 1 3 6 1 0 0.470 0.999 1.000 316 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), HADHA(2), MYST3(4), MYST4(3), PNPLA3(2), SH3GLB1(2), YOD1(1) 20234780 41 36 34 6 2 5 6 12 16 0 0.207 1.000 1.000 317 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(4), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(1), PSMD11(3), PSMD13(2), PSMD2(5), PSMD6(1) 10694207 25 22 24 6 1 3 3 6 12 0 0.593 1.000 1.000 318 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(7), ATF2(1), AXIN1(3), BMP10(1), BMP2(2), BMP4(1), BMP5(1), BMP7(3), BMPR2(5), CHRD(3), CTNNB1(1), DVL1(1), FZD1(2), GATA4(2), GSK3B(3), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(5), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(3) 23282567 53 46 51 8 5 6 4 24 14 0 0.0559 1.000 1.000 319 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX5(2), CBR1(2), CYP4F2(2), EPX(2), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(3), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3), TPO(4) 17956538 40 37 37 8 4 6 9 11 9 1 0.191 1.000 1.000 320 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(2), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(1), JUN(2), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK7(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(1), MEF2D(1), MKNK1(2), MKNK2(1), MYC(1), NFKB1(1), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(5), RIPK1(1), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(2), TRAF2(1) 62711428 140 99 130 18 15 14 9 55 44 3 0.00621 1.000 1.000 321 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(2), CD3G(2), ETV5(1), IL12RB1(2), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(6) 12283508 26 25 25 6 2 1 3 13 7 0 0.623 1.000 1.000 322 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1) 4779260 5 5 5 3 0 1 0 3 1 0 0.950 1.000 1.000 323 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(1), CALM2(1), EGFR(10), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), MEF2A(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(1), PTK2B(3), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SRC(2), SYT1(1) 22267611 52 42 50 10 6 12 5 18 11 0 0.190 1.000 1.000 324 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(2) 9047276 19 18 19 5 1 3 4 7 4 0 0.489 1.000 1.000 325 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(2), CALCRL(1), CD97(4), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(2), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(3), LPHN1(2), LPHN2(3), LPHN3(9), SCTR(1), VIPR1(1) 18037113 41 35 41 9 6 5 4 19 7 0 0.197 1.000 1.000 326 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(2), JAK1(5), JAK2(5), JAK3(3), PIAS3(2), PTPRU(5), SRC(2), STAT3(3) 9856128 27 24 27 9 1 3 3 11 9 0 0.850 1.000 1.000 327 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), GREB1(13), HSPB2(2), MTA1(1), MTA3(2) 6796750 20 19 17 6 0 1 2 13 4 0 0.825 1.000 1.000 328 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), PC(3), PCK1(4), SDHA(1), SDHB(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 13517464 36 32 33 9 2 3 5 15 11 0 0.589 1.000 1.000 329 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(7), AXIN1(3), CTNNB1(1), DVL1(1), FZD1(2), GNAI1(1), GSK3B(3), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(5), TLR4(2) 18083669 37 37 32 7 2 7 4 12 11 1 0.156 1.000 1.000 330 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(7), AXIN1(3), CREBBP(6), CTNNB1(1), DVL1(1), EP300(11), FZD1(2), GSK3B(3), HDAC1(2), LDB1(1), LEF1(1), PITX2(2), TRRAP(8) 21404191 48 42 40 7 2 3 8 19 16 0 0.107 1.000 1.000 331 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 10 AHCY(1), BHMT(2), CTH(1), DNMT3B(1), MARS(2), MARS2(3) 8048154 10 10 10 3 1 1 2 5 1 0 0.669 1.000 1.000 332 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), JUN(2), KEAP1(2), MAPK14(1), NFE2L2(7), PRKCA(2) 5598849 15 15 15 6 1 3 2 7 2 0 0.768 1.000 1.000 333 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(2), CREB5(2), DUSP4(1), DUSP9(1), EEF2K(1), EIF4E(1), GRB2(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), SHC1(3), SOS1(6), SOS2(3), TRAF3(1) 19323486 39 36 35 7 4 5 5 14 9 2 0.314 1.000 1.000 334 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(7), AXIN1(3), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), GSK3B(3), NOTCH1(5) 12978526 25 24 22 5 2 3 3 11 6 0 0.305 1.000 1.000 335 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(4), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(4), SLC18A3(1), TH(2), TPH1(1) 8959575 19 18 17 7 1 3 4 4 7 0 0.840 1.000 1.000 336 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC4(1) 4821591 9 8 9 6 2 0 2 4 1 0 0.943 1.000 1.000 337 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR2(2), ITPKA(1), PDE1A(1), PDE1B(5), PLCB1(1), PLCB2(2) 6946267 12 12 12 9 3 2 0 4 3 0 0.981 1.000 1.000 338 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(5), ATM(16), ATR(7), CCNA1(8), CCNE1(2), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), E2F1(1), GSK3B(3), HDAC1(2), RB1(2), SKP2(1), TGFB2(2), TGFB3(1) 19208785 63 54 55 13 2 9 6 19 27 0 0.355 1.000 1.000 339 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), EDNRB(3), EGF(4), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(1), PLCG1(2), PRKCA(2), RELA(5) 13362042 35 31 29 8 4 4 4 11 11 1 0.531 1.000 1.000 340 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(2), EIF4A2(3), EIF4B(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(2), PDK2(2), PIK3R1(2), PPP2CA(1), RPS6KB1(2), TSC1(2), TSC2(6) 16198912 34 31 32 7 2 5 3 14 10 0 0.346 1.000 1.000 341 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), FOS(1), IKBKB(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TLR10(2), TLR2(2), TLR4(2), TLR6(1), TLR7(4), TLR9(1), TRAF6(2) 23441123 43 39 39 7 3 8 2 15 14 1 0.185 1.000 1.000 342 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD8(1), ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), RDH11(3), SLC27A5(2), SOAT1(4), SOAT2(3) 20802444 41 37 36 8 5 3 3 17 13 0 0.351 1.000 1.000 343 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCAIP(2), UBE2E2(1) 4184639 5 5 5 3 0 3 1 0 1 0 0.829 1.000 1.000 344 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(2), ACTG2(1), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(4), FLNC(5), FSCN1(3), FSCN3(2), GDI2(1), LIMK1(4), MYH2(9), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6) 30169321 68 55 66 12 4 13 3 22 26 0 0.170 1.000 1.000 345 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PITX2(2), PLD1(3), PLD2(7), PLD3(3) 28922609 54 42 52 8 6 9 9 19 11 0 0.0164 1.000 1.000 346 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), NT5M(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2), RRM1(3), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2) 37263633 78 60 70 12 3 11 11 22 30 1 0.0503 1.000 1.000 347 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(5), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(4), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(2), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(3), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(2), TPO(4), TYR(5), TYRP1(1) 38483713 92 75 88 15 7 8 13 37 27 0 0.0846 1.000 1.000 348 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3) 8497018 16 16 16 5 3 1 1 10 1 0 0.597 1.000 1.000 349 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), SELE(5), SELP(2) 10666870 27 25 27 8 1 7 5 7 7 0 0.556 1.000 1.000 350 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), NFAT5(8), PDE6A(1), PDE6B(3), PDE6C(2), SLC6A13(2) 23627157 41 37 40 8 5 4 7 18 7 0 0.166 1.000 1.000 351 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(2), EIF2B5(2), EIF2S2(2), EIF4E(1), GSK3B(3), IGF1R(1), INPPL1(2), PDK2(2), PIK3R1(2), PPP2CA(1), RPS6KB1(2) 10903105 20 19 18 5 1 3 0 7 9 0 0.563 1.000 1.000 352 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(4), ASNS(1), ASPA(1), ASRGL1(4), ASS1(2), CAD(9), CRAT(1), DARS(1), DARS2(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), NARS2(4), PC(3), PDHA1(1), PDHA2(2), PDHB(1) 24693317 58 45 51 10 2 5 11 14 25 1 0.162 1.000 1.000 353 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 20 19 20 7 0 3 5 6 6 0 0.763 1.000 1.000 354 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 20 19 20 7 0 3 5 6 6 0 0.763 1.000 1.000 355 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 20 19 20 7 0 3 5 6 6 0 0.763 1.000 1.000 356 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(2), IL1B(1), IL6R(2), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1) 8490160 15 15 13 5 2 4 0 3 6 0 0.728 1.000 1.000 357 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(2), AKT1(2), BAX(1), CSF2RB(1), IGF1R(1), IL3(1), KIT(3), KITLG(2), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 12738720 26 26 26 7 5 2 1 15 3 0 0.468 1.000 1.000 358 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(3), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(5), RENBP(2) 18875362 37 35 34 7 5 4 5 13 10 0 0.129 1.000 1.000 359 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3) 8913722 16 16 16 5 3 1 1 10 1 0 0.595 1.000 1.000 360 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(3), NCOA2(9), NCOA3(5), NCOR2(7), POLR2A(8), RARA(4), TBP(1) 16358051 41 32 35 9 2 5 6 9 19 0 0.308 1.000 1.000 361 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(1), IL1R1(1), IRAK1(3), MAP3K1(6), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(5), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(2), TRAF6(2) 15645914 28 25 25 8 1 7 2 5 12 1 0.679 1.000 1.000 362 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(4), ASNS(1), ASPA(1), CAD(9), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), PC(3) 16996699 36 32 32 7 1 3 9 5 17 1 0.393 1.000 1.000 363 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAX(1), BCL2A1(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DAXX(5), DFFB(1), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(6), PTPN13(8), RIPK1(1), TFG(2), TNFRSF1A(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 28439569 50 44 49 9 3 8 6 23 10 0 0.148 1.000 1.000 364 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), GPI(3), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(2), TKT(1) 12977377 26 25 24 9 1 4 4 7 10 0 0.815 1.000 1.000 365 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA14(3), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(4), HAL(1) 12473657 23 22 23 6 1 3 2 16 1 0 0.538 1.000 1.000 366 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(6), EP300(11), IKBKB(1), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFBR2(1), TLR2(2) 19371642 36 32 30 6 2 4 4 12 13 1 0.333 1.000 1.000 367 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10593136 20 19 20 7 0 3 5 6 6 0 0.761 1.000 1.000 368 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(7), NRG2(3), NRG3(2), PRKCA(2) 6056416 14 14 14 5 1 4 1 6 2 0 0.730 1.000 1.000 369 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5903596 6 6 6 3 0 0 1 5 0 0 0.813 1.000 1.000 370 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5903596 6 6 6 3 0 0 1 5 0 0 0.813 1.000 1.000 371 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(2) 7898767 15 15 15 6 0 4 3 6 2 0 0.814 1.000 1.000 372 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(7), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(3), CD1E(2), CD2(2), CD22(4), CD24(1), CD33(1), CD34(2), CD38(1), CD3E(2), CD3G(2), CD44(2), CD55(1), CD8A(1), CR1(7), CR2(2), CSF1R(6), CSF2RA(4), CSF3R(3), DNTT(4), FLT3(6), GYPA(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL9R(2), ITGA1(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGAM(5), ITGB3(1), KIT(3), KITLG(2), MME(6), MS4A1(1), TFRC(2), TPO(4) 52645767 132 94 124 25 8 14 16 49 45 0 0.170 1.000 1.000 373 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(7), SHC1(3), SOS1(6), SYK(1), VAV1(3), VAV2(4) 20598662 43 37 39 9 5 6 3 18 10 1 0.304 1.000 1.000 374 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(4) 6631308 4 3 4 6 2 0 0 1 1 0 0.995 1.000 1.000 375 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(2), DPM2(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(6), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(3), SOS1(6) 8657332 28 26 26 8 1 6 2 13 6 0 0.721 1.000 1.000 376 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(2), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3R1(2), RAC1(1), RAF1(1), RB1(2), RELA(5) 11851216 30 24 24 7 2 5 2 8 12 1 0.666 1.000 1.000 377 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(2), CREB5(2), RAF1(1), SNX13(3), SRC(2) 7645801 13 10 13 5 0 5 1 5 1 1 0.745 1.000 1.000 378 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(5), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3) 15947146 35 32 31 9 2 5 4 13 10 1 0.627 1.000 1.000 379 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(11), MAPK3(1), PELP1(1), SRC(2) 9572843 21 18 18 7 2 3 4 6 6 0 0.704 1.000 1.000 380 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACADM(1), ACADS(3), ACOX1(1), ACOX3(2), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CPT1C(4), CPT2(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(5), GCDH(3), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PECI(1) 31354484 62 56 53 12 5 6 12 20 19 0 0.187 1.000 1.000 381 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), PRKCA(2), RAF1(1), RELA(5) 9892034 18 18 15 6 4 3 0 5 5 1 0.725 1.000 1.000 382 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(4), IMPA2(3) 7466458 7 6 7 7 3 0 0 2 2 0 0.993 1.000 1.000 383 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(3), ILVBL(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(2), VARS2(2) 11227977 23 19 23 9 0 6 2 9 6 0 0.776 1.000 1.000 384 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(2), GHR(1), HRAS(1), IGF1R(1), PIK3R1(2), SHC1(3) 7101553 12 11 12 6 2 2 1 5 2 0 0.901 1.000 1.000 385 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(5), GNS(1), GUSB(7), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NAGLU(2), NEU1(1), SPAM1(6) 21861110 53 44 51 11 7 8 7 23 8 0 0.116 1.000 1.000 386 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(3), AKT3(2), GRB2(2), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(5), JAK2(5), JAK3(3), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(6), SOS2(3), SRC(2), STAT6(4), TYK2(6) 22441811 61 51 60 13 2 10 11 23 15 0 0.277 1.000 1.000 387 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(5) 9877713 15 15 15 6 0 3 0 9 3 0 0.875 1.000 1.000 388 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BAX(1), BID(1), BIK(1), BIRC2(3), BIRC3(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1) 8930987 14 14 14 5 0 2 2 6 4 0 0.788 1.000 1.000 389 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(4), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), PPP1R12B(1), PRKCA(2), ROCK1(4) 13493006 26 26 26 8 1 2 0 16 7 0 0.781 1.000 1.000 390 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(2), ARF1(1), BTK(1), EEA1(6), GSK3A(2), GSK3B(3), PFKL(1), PFKM(3), PFKP(2), PLCG1(2), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(4) 16531177 37 32 34 9 2 6 5 12 12 0 0.467 1.000 1.000 391 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(5), BTK(1), CDC42(1), CFL1(1), GDI2(1), INPPL1(2), ITPR1(4), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(2), PPP1R13B(3), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(4), WASL(6) 44028804 90 71 87 14 5 20 10 31 24 0 0.0137 1.000 1.000 392 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(1), AASDHPPT(2), AASS(5), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(4), GCDH(3), HADH(1), HADHA(2), HSD17B4(1), NSD1(8), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(3), PLOD2(4), RDH11(3), SETD1A(4), SETD7(1), SETDB1(6), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(4), TMLHE(1) 36182531 91 72 84 18 7 16 12 27 29 0 0.120 1.000 1.000 393 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(5), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(3), C2(2), C3(6), C3AR1(1), C4BPA(3), C4BPB(2), C5(5), C5AR1(2), C6(1), C7(3), C8A(1), C8B(2), C8G(1), CD55(1), CFB(5), CFH(5), CFI(1), CPB2(5), CR1(7), CR2(2), F11(1), F12(3), F13A1(1), F13B(2), F2(3), F5(8), F7(1), F8(5), F9(2), FGA(2), FGG(5), KLKB1(2), KNG1(2), MASP1(2), MASP2(1), MBL2(1), PLAT(4), PLAU(4), PLAUR(2), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPIND1(2), SERPINF2(2), SERPING1(3), TFPI(1), VWF(11) 57965285 152 114 144 29 13 19 16 67 35 2 0.0326 1.000 1.000 394 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(2), HRAS(1), MAP2K3(3), MAP2K6(1), MAP3K1(6), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(3), PLCB1(1), PPP3CA(2), PPP3CC(3), RAC1(1), RAF1(1), RELA(5), SYT1(1) 25044200 61 49 55 13 6 7 3 21 23 1 0.387 1.000 1.000 395 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(1), FYN(2), ITGA1(5), ITGB1(4), L1CAM(5), SELP(2) 10345754 20 18 19 8 2 3 2 8 5 0 0.850 1.000 1.000 396 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), ASRGL1(4), CA14(3), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(4), HAL(1) 13903166 27 26 24 7 1 3 2 16 5 0 0.562 1.000 1.000 397 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), GPI(3), PFKL(1), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(2), TKT(1), TKTL1(1), TKTL2(3) 15635698 31 30 29 9 1 5 4 10 11 0 0.683 1.000 1.000 398 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(7), AXIN1(3), AXIN2(1), CER1(1), CSNK1A1(2), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(2), GSK3A(2), GSK3B(3), LRP1(14), MVP(4), NKD1(2), NKD2(1), PTPRA(3), SENP2(1), WIF1(4) 26105870 63 54 59 13 4 10 8 22 19 0 0.148 1.000 1.000 399 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(1), BCHE(2), CES1(7), CES2(2), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2) 15191546 32 25 27 8 2 3 4 9 14 0 0.712 1.000 1.000 400 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(1), B4GALT3(2), B4GALT5(1), DPAGT1(5), DPM1(1), MAN1A1(2), MGAT4A(3), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1) 12592340 24 24 24 9 0 6 0 11 7 0 0.834 1.000 1.000 401 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PLCG1(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2) 13912285 32 30 30 8 3 4 4 13 8 0 0.613 1.000 1.000 402 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2) 6422822 11 11 11 5 2 2 1 5 1 0 0.688 1.000 1.000 403 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3) 6802671 11 11 10 5 2 1 2 5 1 0 0.743 1.000 1.000 404 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(1), GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), GTF2H2(2), ILK(4), MNAT1(1), POLR1A(4), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3B(3), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TAF7(1), TBP(1) 23174090 49 44 45 9 1 6 5 18 19 0 0.268 1.000 1.000 405 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(4), MAPK10(1), MAPK7(1), MAPK9(2), NFATC3(5), NR2C2(1), PAPPA(1), SHC1(3), TRAF6(2), ZAK(3) 32050460 72 63 68 13 5 8 10 31 18 0 0.119 1.000 1.000 406 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(7), CALM2(1), CAPN2(2), EP300(11), HDAC1(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(2), PPP3CC(3), PRKCA(2), SYT1(1) 15555640 39 32 34 10 4 4 4 14 13 0 0.485 1.000 1.000 407 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(2), PRKCA(2), PTK2B(3), SYT1(1) 8980806 15 14 14 7 2 4 1 4 4 0 0.908 1.000 1.000 408 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(2), GNAI1(1), GNB1(2), GRB2(2), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(3), MYLK(4), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(6), STAT1(4), STAT3(3), STAT5A(2), SYT1(1) 27480771 59 52 57 12 4 9 6 24 16 0 0.306 1.000 1.000 409 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(3), BLVRA(1), COX10(2), COX15(1), CP(1), CPOX(6), EPRS(3), FECH(2), FTMT(3), GUSB(7), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), PPOX(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UROD(1) 27766131 69 60 61 15 5 8 9 28 19 0 0.300 1.000 1.000 410 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(2), VNN1(1) 11219940 22 21 22 8 1 4 4 8 5 0 0.752 1.000 1.000 411 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3R1(2), PLCG1(2), RAF1(1), SHC1(3), SOS1(6) 10787517 25 24 24 7 3 5 1 12 4 0 0.684 1.000 1.000 412 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 14 ACADM(1), ACADS(3), ACSL1(2), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(5), HADHA(2), PECR(1), SCP2(2) 10119412 19 18 17 7 2 4 6 4 3 0 0.525 1.000 1.000 413 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(2), ARHGEF1(2), F2(3), GNA12(1), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2B(3), ROCK1(4) 15370591 29 28 29 9 2 4 1 14 8 0 0.700 1.000 1.000 414 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(8), CBL(2), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(2), CD8A(1), CDC42(1), CDK4(6), CHUK(1), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IKBKB(1), IL4(1), ITK(2), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NCK1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(6), RASGRP1(2), SOS1(6), SOS2(3), TEC(6), VAV1(3), VAV2(4) 63714902 156 115 146 27 8 21 19 66 42 0 0.0687 1.000 1.000 415 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), CHRNB1(2), MUSK(1), PIK3R1(2), PTK2(1), PTK2B(3), SRC(2), TERT(5) 9240306 18 16 18 6 2 8 0 5 3 0 0.646 1.000 1.000 416 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), SDHB(1) 16974815 31 30 27 8 4 5 6 7 9 0 0.409 1.000 1.000 417 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG1(1), ASL(4), CPS1(5), GATM(2), OAT(1), ODC1(2), OTC(1), PYCR1(1), SMS(2) 11356087 21 20 21 7 1 2 4 10 4 0 0.801 1.000 1.000 418 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(2), ADCY4(2), ADCY6(1), ADCY8(9), CACNA1A(5), CACNA1B(4), GNAS(4), GNB1(2), GNB3(2), GNG3(1), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(5), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(2), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(2) 36438522 81 70 79 16 14 6 7 33 21 0 0.179 1.000 1.000 419 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), CD3E(2), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PIK3R1(2), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PTPN7(1), RAC1(1), RAF1(1), RASA1(3), RELA(5), SHC1(3), SOS1(6), SYT1(1), VAV1(3) 29309427 72 62 66 16 6 15 5 22 23 1 0.343 1.000 1.000 420 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), SOAT2(3) 15300366 27 25 24 8 2 2 2 13 8 0 0.864 1.000 1.000 421 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GFPT1(1), GNE(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2) 11123051 14 13 14 6 3 0 2 6 3 0 0.858 1.000 1.000 422 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLB(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(4), POLH(5), POLI(3), POLK(3), POLL(2), POLM(3), POLQ(8), PRIM1(2), PRIM2(4), REV1(2), REV3L(13), RFC5(1) 27198763 68 54 62 14 4 4 4 33 23 0 0.485 1.000 1.000 423 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(1), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), JUN(2), LMNB1(3), MAP3K1(6), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(11), PTPN13(8), RB1(2), RIPK2(2), SPTAN1(6) 28042411 58 49 58 10 3 8 7 24 16 0 0.113 1.000 1.000 424 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(1), ARSE(1), CYP11B2(2), HSD17B2(1), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 17731963 24 22 24 6 2 3 3 7 9 0 0.468 1.000 1.000 425 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(9), CPS1(5), EPRS(3), GAD2(1), GCLC(1), GFPT1(1), GLS(4), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSS(1), NADSYN1(1), QARS(1) 21914311 42 35 38 9 2 4 7 15 13 1 0.474 1.000 1.000 426 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(5), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 10442846 23 21 23 8 2 4 2 10 5 0 0.606 1.000 1.000 427 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(2), CABIN1(7), CALM2(1), CAMK1(1), CAMK1G(3), IGF1R(1), INSR(6), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2D(1), NFATC1(2), NFATC2(5), PIK3R1(2), PPP3CA(2), PPP3CC(3), SYT1(1) 20750278 41 37 36 9 4 6 3 12 16 0 0.369 1.000 1.000 428 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(2), AKT2(3), AKT3(2), CASP8(1), CCL3(1), CD86(1), CHUK(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IKBKB(1), IKBKE(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(1), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), NFKB2(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(5), RIPK1(1), SPP1(3), STAT1(4), TBK1(2), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(4), TLR8(5), TLR9(1), TRAF3(1), TRAF6(2) 56148144 111 95 106 19 9 18 12 53 18 1 0.0273 1.000 1.000 429 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BAX(1), BFAR(1), BTK(1), CAD(9), CASP10(3), CASP8(1), CASP8AP2(4), CSNK1A1(2), DAXX(5), DEDD(2), EGFR(10), EPHB2(2), FAIM2(1), MAP2K7(1), MAP3K1(6), MAP3K5(5), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(6), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(8), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TPX2(1), TRAF2(1) 47000460 98 79 90 17 9 9 8 43 28 1 0.101 1.000 1.000 430 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(1), ALAS1(5), ALAS2(3), AOC2(4), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(5), GATM(2), GLDC(3), MAOA(1), PISD(1), PLCB2(2), PLCG1(2), PLCG2(2), SARDH(4), SARS(3), SHMT1(2), SHMT2(3), TARS(6) 27427385 66 58 62 15 6 9 12 22 17 0 0.198 1.000 1.000 431 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(9), ATF4(2), BRAF(2), CACNA1C(10), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(6), EP300(11), GRIA1(6), GRIA2(3), GRIN1(2), GRIN2A(6), GRIN2B(6), GRM1(5), GRM5(8), HRAS(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PPP1R12A(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), RAP1A(1), RAPGEF3(2), RPS6KA1(7), RPS6KA6(1) 66267243 150 110 140 28 19 17 12 62 38 2 0.0417 1.000 1.000 432 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAF1(1), SYT1(1) 21997311 53 46 50 13 7 6 2 22 16 0 0.531 1.000 1.000 433 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(2), ARHGEF11(5), CDC42(1), DLG4(1), GNA13(4), LPA(6), MAP3K1(6), MAP3K5(5), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PLD1(3), PLD2(7), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(2) 31808522 71 60 67 14 4 8 8 31 20 0 0.201 1.000 1.000 434 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(4), FASN(3), OLAH(1), OXSM(1) 10057712 14 14 14 6 2 0 4 6 2 0 0.838 1.000 1.000 435 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(1), APOA2(1), CREBBP(6), EHHADH(5), EP300(11), FABP1(3), HSD17B4(1), JUN(2), LPL(2), MAPK3(1), ME1(1), MYC(1), NCOA1(3), NCOR1(4), NCOR2(7), NR1H3(3), NRIP1(6), PIK3R1(2), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PTGS2(4), RB1(2), RELA(5), SP1(2), SRA1(1), STAT5A(2), STAT5B(2) 39249679 91 64 82 19 5 14 11 36 24 1 0.174 1.000 1.000 436 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(5), EGF(4), EGFR(10), ETS1(1), ETS2(1), FOS(1), HRAS(1), IKBKB(1), JUN(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), RAF1(1), RELA(5), RIPK1(1), SP1(2), TNFRSF1A(1), TRAF2(1) 31927150 77 62 71 17 10 7 3 29 27 1 0.449 1.000 1.000 437 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(3), EGFR(10), ERBB2(4), ERBB4(7), ETS1(1), ETS2(1), ETV6(2), FMN2(6), GRB2(2), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(8), NOTCH3(8), NOTCH4(5), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(6), SOS2(3), SPIRE1(1), SPIRE2(1) 32271932 86 71 83 19 11 8 11 36 18 2 0.303 1.000 1.000 438 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(1), ARSE(1), ASAH1(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1) 15163689 27 25 27 9 2 5 4 10 6 0 0.686 1.000 1.000 439 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX11(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2), VAMP2(1) 11051827 16 14 16 8 2 2 2 8 2 0 0.865 1.000 1.000 440 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DFFB(1), LMNB1(3), PRF1(1) 12493614 22 21 22 7 0 6 3 9 4 0 0.639 1.000 1.000 441 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GHR(1), GRB2(2), HRAS(1), INSR(6), IRS1(4), JAK2(5), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), PTPN6(3), RAF1(1), RPS6KA1(7), SHC1(3), SLC2A4(1), SOS1(6), SRF(1), STAT5A(2), STAT5B(2) 19868821 52 46 44 13 5 7 6 17 16 1 0.604 1.000 1.000 442 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(2), AGT(1), AGTR1(2), ANPEP(7), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(6), REN(1), THOP1(1) 13831036 35 31 30 10 1 4 9 12 9 0 0.754 1.000 1.000 443 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(1), CABIN1(7), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(2), CDKN1A(1), CNR1(1), CREBBP(6), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(11), FOS(1), GATA3(2), GATA4(2), GRLF1(6), GSK3A(2), GSK3B(3), HRAS(1), ICOS(2), IFNA1(2), IFNB1(3), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PAK1(2), PPP3CC(3), PTPRC(6), RELA(5), SLA(1), SP1(2), SP3(2), TRAF2(1), TRPV6(4), VAV1(3), VAV2(4), XPO5(3) 58343361 145 104 133 29 12 19 16 53 44 1 0.0936 1.000 1.000 444 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC1B(1), CFL1(1), DIAPH1(3), GSN(2), LIMK1(4), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(7), VCL(2) 29221627 52 48 49 10 2 6 2 20 22 0 0.392 1.000 1.000 445 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(7), G6PD(2), GCLC(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(2), IDH1(2), IDH2(5), OPLAH(2), TXNDC12(1) 14138763 35 31 32 10 1 2 7 15 10 0 0.785 1.000 1.000 446 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(5), ACO1(4), CLYBL(2), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), OGDHL(2), PC(3), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 19614320 50 43 47 14 3 7 5 21 14 0 0.660 1.000 1.000 447 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(3), CREB5(2), ERBB4(7), F2RL2(1), GAB1(1), GRB2(2), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), MET(6), MYC(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARD3(5), PDK1(1), PIK3CD(1), PPP1R13B(3), PREX1(6), PTK2(1), PTPN1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(6), SOS2(3), TSC1(2), TSC2(6), YWHAE(1) 47094902 106 84 97 21 9 14 10 41 31 1 0.207 1.000 1.000 448 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DFFB(1), GAS2(3), MAP3K14(1), NFKB1(1), RELA(5), RIPK1(1), SPTAN1(6), TNFSF10(6), TRADD(2), TRAF2(1) 21839088 43 36 37 10 1 5 5 15 16 1 0.550 1.000 1.000 449 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CP(1), CPOX(6), EPRS(3), FECH(2), GUSB(7), HCCS(1), HMOX1(2), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UROD(1) 18053735 41 37 35 11 4 4 5 14 14 0 0.629 1.000 1.000 450 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), CREB5(2), DUSP10(1), EEF2K(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(2) 21858948 43 40 43 10 3 8 0 25 7 0 0.336 1.000 1.000 451 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH4A1(1), CAD(9), CPS1(5), EPRS(3), GAD2(1), GCLC(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(2), QARS(1) 26048357 47 38 43 10 3 4 9 16 14 1 0.411 1.000 1.000 452 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(5), ATM(16), BRCA1(7), CDKN1A(1), CHEK2(1), JUN(2), MRE11A(1), NFKB1(1), RAD50(4), RAD51(2), RELA(5), TP73(3) 18875186 48 43 45 11 2 8 5 19 13 1 0.489 1.000 1.000 453 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(1), AGPS(1), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLD1(3), PLD2(7), PPAP2B(1), PPAP2C(2) 15330061 26 24 23 9 3 2 4 11 6 0 0.762 1.000 1.000 454 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(2), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), MAPK7(1), PLD1(3), PLD2(7), PLD3(3), PTK2(1), RAF1(1), RASAL1(5), SRC(2), TEC(6), VAV1(3) 17863193 45 40 39 12 4 3 5 18 15 0 0.721 1.000 1.000 455 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(2), ATM(16), ATR(7), BAI1(1), BAX(1), BBC3(1), BID(1), CASP8(1), CASP9(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNG2(1), CD82(3), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), RCHY1(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(11), TP53I3(6), TP73(3), TSC2(6) 41219685 104 81 97 21 6 16 14 30 38 0 0.166 1.000 1.000 456 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX5(2), CYP1A2(3), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP3A7(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), RDH11(3) 15699422 24 24 23 8 4 2 3 11 4 0 0.610 1.000 1.000 457 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SULT2A1(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3) 32479861 51 46 51 11 5 7 7 19 13 0 0.287 1.000 1.000 458 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(2), ASAH1(2), BRAF(2), DRD2(1), EGFR(10), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), PIK3CB(3), PITX2(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SRC(2), STAT3(3) 38247862 83 62 81 18 9 13 13 32 15 1 0.116 1.000 1.000 459 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(5), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADH(1), HADHA(2), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), TPH1(1), TPH2(1), WARS(1), WARS2(4) 39559123 77 65 70 16 4 13 12 29 19 0 0.196 1.000 1.000 460 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), MAPK3(1), PIK3R1(2), RAF1(1), SHC1(3), SOS1(6) 10615957 23 21 23 8 5 5 1 10 2 0 0.633 1.000 1.000 461 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFB(1), JUN(2), LMNB1(3), MADD(6), MAP3K1(6), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(11), RB1(2), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1) 25861196 51 45 51 11 1 9 7 18 16 0 0.246 1.000 1.000 462 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(7), ASAH1(2), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(4), ITPR2(10), ITPR3(4), KCNJ3(3), PITX2(2), RAC1(1), RHO(1), RYR1(13) 29642229 53 48 53 12 9 8 8 20 8 0 0.140 1.000 1.000 463 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), EGFR(10), IGF1R(1), MYC(1), POLR2A(8), PPP2CA(1), PRKCA(2), RB1(2), TEP1(4), TERT(5), TNKS(4), XRCC5(3) 17815217 43 35 41 12 6 9 5 12 11 0 0.363 1.000 1.000 464 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CEL(1), DAK(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(5), GPAM(2), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2) 38525819 73 60 70 16 6 12 10 24 21 0 0.236 1.000 1.000 465 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(9), CASP1(2), CASP7(1), CASP8(1), GAPDH(2), INSR(6), MAGI1(4), MAGI2(4), RERE(3), WWP2(3) 15438477 35 31 26 10 4 4 4 9 12 2 0.872 1.000 1.000 466 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(1), ALG6(2), ALG8(2), B4GALT3(2), DOLPP1(2), DPAGT1(5), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), RFT1(1), RPN1(2), RPN2(1), STT3B(3) 27562098 59 49 58 14 0 14 2 24 19 0 0.461 1.000 1.000 467 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(3), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(2), HERPUD1(1), HSPA8(7), IDI1(1), KLF9(2), MYF6(2), NCKAP1(2), NCOA4(5), NR1D2(1), PER1(5), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(6) 23817899 59 52 58 14 2 10 11 21 14 1 0.273 1.000 1.000 468 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(6), STAT1(4), STAT3(3), STAT5A(2), STAT5B(2) 18178229 42 39 40 11 4 6 3 18 11 0 0.689 1.000 1.000 469 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(3), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(4), ITPR2(10), ITPR3(4), PDK1(1), PHF11(1), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTPRC(6), RPS6KA1(7), RPS6KB1(2), SAG(4), SYK(1), TEC(6), VAV1(3) 34399400 78 68 74 18 6 14 9 28 20 1 0.202 1.000 1.000 470 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ACY1(1), ADC(1), AGMAT(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(4), AOC3(1), ARG1(1), ASL(4), ASS1(2), CPS1(5), GATM(2), MAOA(1), ODC1(2), OTC(1), SAT1(1), SAT2(1), SMS(2) 19122684 46 43 44 13 1 6 8 19 12 0 0.654 1.000 1.000 471 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(8), CD19(1), CD22(4), CD72(1), CHUK(1), CR2(2), FOS(1), GSK3B(3), HRAS(1), IKBKB(1), INPP5D(2), JUN(2), KRAS(1), LILRB3(4), MALT1(2), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(4) 46727648 106 86 97 23 6 16 9 42 33 0 0.271 1.000 1.000 472 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(3), CDC20(1), CDC23(2), CDC27(2), CUL1(3), CUL2(1), CUL3(6), FBXW11(1), FBXW7(2), FZR1(4), SKP2(1), SMURF2(3), TCEB1(4), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP2(3) 26678924 60 59 55 14 3 7 5 25 19 1 0.538 1.000 1.000 473 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(5), ACACB(4), ACADM(1), ACSS1(3), ACSS2(7), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(5), HADHA(2), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2) 26298582 61 51 56 16 3 7 15 15 20 1 0.513 1.000 1.000 474 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(2), ATM(16), BAX(1), BID(1), CASP7(1), CASP9(1), PRKCA(2), PTK2(1), PXN(1), STAT1(4), TLN1(7) 17564613 39 35 39 10 2 5 3 16 13 0 0.591 1.000 1.000 475 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(2), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 17018286 24 23 24 8 0 5 6 10 3 0 0.587 1.000 1.000 476 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(4), CR2(2), CSK(3), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPP5D(2), ITPR1(4), ITPR2(10), ITPR3(4), MAP4K1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(1), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), PPP3CA(2), PPP3CC(3), PTPRC(6), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SYK(1), VAV1(3) 46457051 95 71 89 20 8 16 9 33 29 0 0.109 1.000 1.000 477 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CSK(3), CTLA4(1), DTYMK(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(2), ITK(2), ITPKA(1), ITPKB(1), LCP2(1), NCK1(1), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLCG1(2), PTPRC(6), RAF1(1), RASGRP1(2), RASGRP2(4), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(3), VAV1(3) 36156246 75 60 72 17 6 10 8 30 21 0 0.423 1.000 1.000 478 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(5), HADHA(2), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2) 21966427 47 43 43 13 3 5 11 14 14 0 0.533 1.000 1.000 479 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(4), KHK(5), MPI(2), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(3), PFKP(2), PGM2(2), PMM1(1), RDH11(3), TPI1(1) 23884258 45 42 45 12 8 3 7 14 13 0 0.483 1.000 1.000 480 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GALM(2), GAPDH(2), GAPDHS(2), GPI(3), HK1(4), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKL(1), PFKM(3), PFKP(2), PGAM1(1), PGAM2(1), PGK1(3), PKM2(1), TPI1(1) 37949123 88 69 79 22 6 7 11 30 33 1 0.609 1.000 1.000 481 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ALG6(2), CCKBR(2), CELSR1(12), CELSR2(6), CELSR3(5), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(2), EMR3(9), FSHR(2), GPR116(4), GPR133(3), GPR17(2), GPR61(1), GPR77(1), GPR84(4), GRM1(5), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(9), NTSR1(1), OR8G1(2), OR8G2(2), P2RY13(1), PTGFR(3), SMO(3), TSHR(2) 41481571 96 74 92 23 14 17 6 34 25 0 0.162 1.000 1.000 482 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(13), B3GALT4(1), CDR1(2), DGKI(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL23(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(2), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(1), RPS19(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS9(1), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(3) 33964219 86 75 81 19 5 7 17 32 24 1 0.346 1.000 1.000 483 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), DLAT(2), DLD(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK3(2), PDP2(2), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 18653873 44 36 41 13 1 7 6 17 13 0 0.666 1.000 1.000 484 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PKM2(1) 24117765 49 44 46 13 2 6 7 14 20 0 0.610 1.000 1.000 485 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(3), ACSM1(1), AKR1B10(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(5), GAD2(1), HADH(1), HADHA(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(3), RDH11(3) 26710355 50 44 46 13 7 7 7 15 14 0 0.419 1.000 1.000 486 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(6), CTBP1(1), CTBP2(2), DLL1(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(1), DTX4(4), DVL1(1), DVL2(1), EP300(11), HDAC1(2), JAG1(5), JAG2(2), MAML1(5), MAML2(2), MAML3(6), NCOR2(7), NCSTN(1), NOTCH1(5), NOTCH2(8), NOTCH3(8), NOTCH4(5), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), PTCRA(1), RBPJ(2), RBPJL(7), SNW1(3) 41783564 111 80 101 28 9 10 15 36 39 2 0.549 1.000 1.000 487 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(7), BRCA1(7), BRCA2(8), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(1), RAD17(1), RAD50(4), RAD51(2), TREX1(2) 28845530 62 52 62 13 2 12 7 28 13 0 0.329 1.000 1.000 488 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(3), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(1), NFAT5(8), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(6), SOS2(3), SYK(1), VAV1(3) 32093241 56 47 55 13 5 11 6 23 11 0 0.208 1.000 1.000 489 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(5), GSK3B(3), HHIP(3), LRP2(18), PRKACA(1), PRKACB(5), PRKACG(2), PTCH1(10), PTCH2(2), SHH(1), SMO(3), STK36(2), SUFU(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 37361099 96 78 86 24 10 10 7 44 25 0 0.514 1.000 1.000 490 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(4), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(2), CAMKK2(2), CHUK(1), CPT1A(1), CPT1C(4), CPT2(1), G6PC(3), IKBKB(1), IRS1(4), IRS4(1), JAK1(5), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), POMC(1), PPARGC1A(3), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4), PRKCQ(4), PTPN11(1), RELA(5), RXRB(4), RXRG(2), SLC2A1(1), SLC2A4(1), SOCS3(1), STAT3(3), STK11(1), TNFRSF1A(1), TRADD(2), TRAF2(1), TYK2(6) 51611933 116 92 107 27 5 16 18 37 39 1 0.434 1.000 1.000 491 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GAPDHS(2), GOT1(3), GOT2(2), GPI(3), HK1(4), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(3), PFKP(2), PGAM1(1), PGAM2(1), PGK1(3), PKM2(1), TNFAIP1(1), TPI1(1) 27486661 68 55 64 19 4 6 9 20 29 0 0.658 1.000 1.000 492 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(4), ACSS1(3), ACSS2(7), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(2), PDHB(1), PKM2(1) 30516346 63 53 59 16 2 8 11 15 26 1 0.581 1.000 1.000 493 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(1), ASAH1(2), B4GALT6(1), CERK(5), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(2), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2) 22215704 43 39 40 13 6 7 6 13 11 0 0.587 1.000 1.000 494 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(2), BAX(1), BID(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(3), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CHUK(1), DFFB(1), FAS(1), FASLG(1), HELLS(2), IKBKB(1), IRF5(1), IRF6(5), IRF7(1), JUN(2), LTA(1), MAP3K1(6), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFRSF21(1), TNFSF10(6), TP73(3), TRADD(2), TRAF2(1), TRAF3(1) 36049029 67 52 57 16 1 9 7 24 25 1 0.553 1.000 1.000 495 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(2), ATF1(2), BRAF(2), CREB5(2), CREBBP(6), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(8), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(6), PIK3C2G(3), PIK3CD(1), PIK3R1(2), PTPN11(1), SHC1(3), SRC(2), TH(2) 30792260 61 51 59 16 8 13 3 23 13 1 0.387 1.000 1.000 496 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), ENTPD5(1), NME7(1), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(4), RFC5(1), RRM1(3), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(2) 53777536 98 77 89 20 3 17 12 32 33 1 0.114 1.000 1.000 497 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT6(1), CDS2(1), CHAT(4), CHKB(2), CHPT1(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(2), LCAT(1), LYPLA1(1), MYST3(4), MYST4(3), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLD1(3), PLD2(7), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(2) 42731591 72 57 67 16 9 8 10 24 21 0 0.255 1.000 1.000 498 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(6), DARS(1), EPRS(3), HARS(1), IARS(4), KARS(1), LARS(3), LARS2(2), MARS(2), MARS2(3), QARS(1), RARS(2), SARS(3), TARS(6), WARS(1), WARS2(4), YARS(1) 21368148 46 38 41 12 0 5 7 22 12 0 0.573 1.000 1.000 499 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(2), CERK(5), CREB5(2), EPHB2(2), FOS(1), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 17965013 32 29 29 10 5 4 3 12 8 0 0.695 1.000 1.000 500 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), CEL(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(5), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNLIPRP2(1), PPAP2B(1), PPAP2C(2) 31560764 59 48 56 16 6 11 6 18 18 0 0.518 1.000 1.000 501 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(3), FYN(2), GRB2(2), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAPK3(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(1), RAP1A(1), ROCK1(4), SHC1(3), SOS1(6), SRC(2), TLN1(7), VCL(2), ZYX(1) 30457734 61 51 60 16 5 9 2 29 16 0 0.589 1.000 1.000 502 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(2), DHRS4(3), EPHX2(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(4), TBXAS1(3) 25276434 56 49 53 15 6 6 12 20 11 1 0.384 1.000 1.000 503 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(2), CALR(1), CANX(1), CD74(1), CD8A(1), CIITA(3), CTSB(3), CTSL1(2), CTSS(1), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-E(2), HLA-F(2), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), KIR2DL3(1), KIR2DS4(1), KIR3DL1(3), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), NFYC(2), RFX5(1), RFXAP(1), TAP2(1) 26477226 68 60 67 20 4 9 7 30 18 0 0.817 1.000 1.000 504 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GPI(3), HK1(4), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGAM1(1), PGK1(3), PKM2(1), TPI1(1) 31870819 71 57 63 20 6 4 7 27 27 0 0.780 1.000 1.000 505 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(2), GPI(3), HK1(4), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGAM1(1), PGK1(3), PKM2(1), TPI1(1) 31870819 71 57 63 20 6 4 7 27 27 0 0.780 1.000 1.000 506 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), F11(1), F12(3), F2(3), F5(8), F8(5), F9(2), FGA(2), FGG(5), KLKB1(2), PROC(4), PROS1(4), SERPING1(3) 29418959 63 57 61 19 6 13 4 23 16 1 0.549 1.000 1.000 507 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), ATP7A(3), ATP7B(6), COX10(2), COX6A2(1), COX7A2(1), NDUFA1(1), NDUFA10(2), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(1) 25317507 56 48 55 16 3 11 9 22 11 0 0.479 1.000 1.000 508 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(4), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(2), CAPN2(2), CAV2(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(10), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), CTNNB1(1), DIAPH1(3), DOCK1(1), EGF(4), EGFR(10), ELK1(1), ERBB2(4), FARP2(2), FIGF(2), FLNA(4), FLNB(4), FLNC(5), FLT1(9), FN1(4), FYN(2), GRB2(2), GRLF1(6), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), JUN(2), KDR(5), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), MAPK10(1), MAPK3(1), MAPK9(2), MET(6), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARVB(1), PARVG(1), PDGFC(1), PDGFD(2), PDGFRA(7), PDGFRB(1), PGF(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(2), PRKCA(2), PRKCG(2), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(5), ROCK1(4), ROCK2(3), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SPP1(3), SRC(2), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TLN1(7), TLN2(9), TNC(8), TNN(3), TNR(8), TNXB(5), VAV1(3), VAV2(4), VCL(2), VEGFC(2), VTN(1), VWF(11), ZYX(1) 237555392 523 264 502 155 53 75 57 192 144 2 0.654 1.000 1.000 509 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY7(1), ADCY8(9), ADCY9(4), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), ATP2B4(3), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(8), CACNA1H(4), CACNA1I(4), CACNA1S(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(3), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(4), ERBB3(6), ERBB4(7), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(6), GRM1(5), GRM5(8), GRPR(1), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), MYLK(4), MYLK2(1), NOS1(9), NOS3(3), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), PDE1A(1), PDE1B(5), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PTAFR(2), PTGER3(5), PTGFR(3), PTK2B(3), RYR1(13), RYR2(11), RYR3(12), SLC25A4(2), SLC25A5(1), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(4), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(2), TRHR(2), TRPC1(2), VDAC3(1) 176508822 398 245 380 108 59 49 33 161 96 0 0.209 1.000 1.000 510 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(2), ARRB2(1), ATF2(1), ATF4(2), BRAF(2), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(8), CACNA1H(4), CACNA1I(4), CACNA1S(8), CACNA2D1(3), CACNA2D2(1), CACNA2D4(4), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CDC25B(1), CDC42(1), CHUK(1), DAXX(5), DUSP10(1), DUSP3(2), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(4), EGF(4), EGFR(10), ELK1(1), ELK4(2), FAS(1), FASLG(1), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(4), FGFR4(3), FLNA(4), FLNB(4), FLNC(5), FOS(1), GNA12(1), GNG12(1), GRB2(2), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(4), JUN(2), KRAS(1), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(2), MAP4K2(1), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAPT(3), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(9), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NTRK1(6), NTRK2(1), PAK1(2), PAK2(2), PDGFRA(7), PDGFRB(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PPM1B(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PPP5C(2), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PTPN5(3), PTPN7(1), PTPRR(4), RAC1(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(7), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(3), RASGRP1(2), RASGRP2(4), RASGRP3(1), RASGRP4(2), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KA6(1), SOS1(6), SOS2(3), SRF(1), TAOK2(3), TAOK3(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(3) 186359868 407 241 391 97 41 54 39 163 108 2 0.115 1.000 1.000 511 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), APC(7), ARHGEF1(2), ARHGEF12(2), ARHGEF6(2), ARHGEF7(5), ARPC1B(1), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(2), C3orf10(2), CDC42(1), CFL1(1), CHRM2(3), CHRM3(2), CHRM5(2), CSK(3), CYFIP1(5), CYFIP2(6), DIAPH1(3), DIAPH2(2), DIAPH3(4), DOCK1(1), EGF(4), EGFR(10), EZR(1), F2(3), FGD1(3), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(4), FGFR4(3), FN1(4), GIT1(2), GNA12(1), GNA13(4), GNG12(1), GRLF1(6), GSN(2), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(5), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAD(9), ITGAE(6), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(1), LIMK1(4), LIMK2(2), MAPK3(1), MOS(1), MRAS(1), MSN(2), MYH10(2), MYH14(4), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), NCKAP1(2), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), RDX(1), ROCK1(4), ROCK2(3), SCIN(2), SLC9A1(2), SOS1(6), SOS2(3), SSH1(2), SSH2(8), SSH3(2), TIAM1(6), TIAM2(1), VAV1(3), VAV2(4), VCL(2), WASF2(2), WASL(6) 179275625 378 221 359 96 26 47 45 149 110 1 0.384 1.000 1.000 512 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(2), CHAD(2), COL11A1(10), COL11A2(4), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), DSC2(3), DSG1(3), DSG2(2), DSG3(2), DSG4(2), FN1(4), GJA10(2), GJA3(1), GJA4(1), GJA5(5), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(2), KRT19(1), KRT2(3), KRT23(2), KRT24(1), KRT25(1), KRT27(2), KRT28(2), KRT3(1), KRT31(1), KRT33B(2), KRT35(1), KRT36(2), KRT39(1), KRT4(3), KRT5(2), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(3), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT77(1), KRT78(3), KRT79(4), KRT82(2), KRT83(1), KRT84(2), KRT85(4), KRT86(1), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), LMNB1(3), NES(8), PRPH(1), RELN(5), SPP1(3), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TNC(8), TNN(3), TNR(8), TNXB(5), VIM(1), VTN(1), VWF(11) 157743068 360 215 347 121 39 53 36 122 109 1 0.900 1.000 1.000 513 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), C5AR1(2), CALCR(2), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(3), CHRM3(2), CHRM5(2), CNR1(1), CNR2(2), CRHR1(1), CRHR2(2), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GABBR1(3), GABRA1(1), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(7), GABRR1(2), GABRR2(1), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(2), GLRA2(1), GLRB(2), GPR156(1), GPR35(2), GPR50(1), GPR63(1), GPR83(1), GRIA1(6), GRIA2(3), GRIA3(2), GRIA4(3), GRID1(3), GRID2(6), GRIK1(3), GRIK2(4), GRIK3(4), GRIK5(4), GRIN1(2), GRIN2A(6), GRIN2B(6), GRIN3B(2), GRM1(5), GRM2(2), GRM3(3), GRM4(3), GRM5(8), GRM6(2), GRM7(4), GRM8(3), GRPR(1), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), LEP(1), LEPR(1), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(3), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(1), P2RY8(2), PARD3(5), PRLR(2), PRSS3(3), PTAFR(2), PTGDR(1), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(3), PTGIR(1), RXFP1(1), RXFP2(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(2), THRA(2), TRHR(2), TSHR(2), VIPR1(1) 140192782 307 196 294 94 44 43 26 118 76 0 0.567 1.000 1.000 514 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD44(2), CHAD(2), COL11A1(10), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(5), COL5A2(5), COL5A3(10), COL6A1(2), COL6A2(6), COL6A3(13), COL6A6(13), FN1(4), FNDC1(1), FNDC3A(3), FNDC5(1), HMMR(1), HSPG2(10), IBSP(1), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(10), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(5), LAMC2(6), LAMC3(5), RELN(5), SDC3(1), SPP1(3), SV2A(1), SV2B(1), SV2C(2), THBS1(11), THBS2(1), THBS3(6), THBS4(3), TNC(8), TNN(3), TNR(8), TNXB(5), VTN(1), VWF(11) 142965294 307 196 297 99 31 45 32 104 94 1 0.840 1.000 1.000 515 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB2(1), ATP1A4(4), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(10), CACNA1D(6), CACNA1E(3), CACNA1S(8), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(4), CASQ2(2), CHRM2(3), CHRM3(2), CHRM5(2), GJA4(1), GJA5(5), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(2), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GRK4(1), GRK5(1), GRK6(5), ITPR1(4), ITPR2(10), ITPR3(4), KCNB1(1), KCNJ3(3), MYCBP(1), NME7(1), PKIA(1), PLCB3(2), PRKACA(1), PRKACB(5), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS3(6), RGS6(2), RGS7(1), RGS9(4), RYR1(13), RYR2(11), RYR3(12), SLC8A1(1), SLC8A3(4), USP5(2) 124492271 269 177 260 73 42 34 23 100 70 0 0.222 1.000 1.000 516 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(2), BMP7(3), BMPR1B(1), BMPR2(5), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(6), CSF2RA(4), CSF2RB(1), CSF3R(3), CX3CR1(1), CXCL11(1), CXCL16(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(10), FAS(1), FASLG(1), FLT1(9), FLT3(6), FLT4(7), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(4), IL20RA(1), IL21(1), IL21R(3), IL22(1), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTB(1), LTBR(2), MET(6), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF10C(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(6), TNFSF14(1), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(4), VEGFC(2), XCL1(2), XCR1(1) 115120482 251 173 237 51 17 36 25 109 64 0 0.0340 1.000 1.000 517 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(5), CASK(1), CDC42(1), CDK4(6), CGN(1), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), EPB41(2), EPB41L1(1), EPB41L2(2), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), IGSF5(4), INADL(4), JAM3(1), KRAS(1), LLGL1(5), LLGL2(2), MAGI1(4), MAGI2(4), MAGI3(4), MLLT4(8), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH10(2), MYH11(8), MYH13(4), MYH14(4), MYH15(3), MYH2(9), MYH3(6), MYH4(10), MYH6(4), MYH7(8), MYH7B(5), MYH8(5), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLPF(3), OCLN(2), PARD3(5), PARD6B(4), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), SPTAN1(6), SRC(2), TJAP1(1), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(3) 126476768 270 171 254 77 29 35 21 89 95 1 0.704 1.000 1.000 518 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ARRB2(1), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(6), ATP2A3(4), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GBA2(4), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GRK4(1), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(3), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(10), ITPR3(4), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(9), NOS3(3), PDE4B(2), PDE4D(2), PKIA(1), PLCB3(2), PLCD1(1), PLCG1(2), PLCG2(2), PRKACA(1), PRKACB(5), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS3(6), RGS6(2), RGS7(1), RGS9(4), RLN1(1), RYR1(13), RYR2(11), RYR3(12), SLC8A1(1), SP1(2), TNXB(5), USP5(2) 112147180 246 170 239 60 35 34 23 92 62 0 0.198 1.000 1.000 519 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(5), ABLIM1(4), ABLIM2(1), ABLIM3(3), ARHGEF12(2), CDC42(1), CFL1(1), CXCR4(1), DCC(4), DPYSL2(3), EFNA3(1), EFNB1(1), EPHA1(3), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(2), EPHB4(4), EPHB6(5), FES(3), FYN(2), GNAI1(1), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(2), MAPK3(1), MET(6), NCK1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NGEF(1), NRP1(2), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(3), PLXNC1(3), PPP3CA(2), PPP3CC(3), PPP3R2(2), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(6), RND1(3), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(6), SEMA4G(2), SEMA5A(5), SEMA5B(1), SEMA6C(4), SEMA6D(3), SLIT1(2), SLIT2(7), SLIT3(6), SRGAP1(4), SRGAP2(2), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(2), UNC5D(2) 125131847 259 168 239 71 21 33 24 96 84 1 0.637 1.000 1.000 520 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(5), ACACB(4), AKT1(2), AKT2(3), AKT3(2), BRAF(2), CALM2(1), CBL(2), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(3), FBP1(1), FLOT1(1), FLOT2(1), FOXO1(2), G6PC(3), GRB2(2), GSK3B(3), GYS1(3), GYS2(1), HRAS(1), IKBKB(1), INPP5D(2), INSR(6), IRS1(4), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(2), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(3), PHKG2(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2), PRKCI(2), PRKCZ(2), PTPN1(1), PTPRF(4), PYGB(2), PYGL(1), PYGM(3), RAF1(1), RAPGEF1(4), RHEB(4), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(1), SHC3(1), SLC2A4(1), SOCS3(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(3), SREBF1(2), TRIP10(1), TSC1(2), TSC2(6) 101175673 215 155 202 39 19 29 25 89 52 1 0.0106 1.000 1.000 521 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(7), AXIN1(3), AXIN2(1), BTRC(2), CACYBP(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(3), CREBBP(6), CSNK1A1(2), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(2), CTNNB1(1), CUL1(3), CXXC4(2), DAAM1(2), DKK2(1), DVL1(1), DVL2(1), EP300(11), FBXW11(1), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GSK3B(3), JUN(2), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), MAPK9(2), MYC(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), VANGL1(1), VANGL2(3), WIF1(4), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 101616687 210 149 199 56 14 22 26 87 61 0 0.485 1.000 1.000 522 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT1(2), AKT2(3), AKT3(2), CBL(2), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(6), CSF2RA(4), CSF2RB(1), CSF3R(3), EP300(11), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL20RA(1), IL21(1), IL21R(3), IL22(1), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(5), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(4), PIAS2(1), PIAS3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(1), SOS1(6), SOS2(3), SPRED1(6), SPRED2(1), SPRY1(1), SPRY2(2), STAM(2), STAT1(4), STAT2(6), STAT3(3), STAT4(1), STAT5A(2), STAT5B(2), STAT6(4), TPO(4), TYK2(6) 92772625 209 144 202 52 12 32 32 84 49 0 0.245 1.000 1.000 523 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(3), CADM1(2), CADM3(1), CD2(2), CD22(4), CD28(1), CD34(2), CD6(2), CD86(1), CD8A(1), CD99(1), CDH1(2), CDH2(6), CDH3(3), CDH4(5), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CNTN1(4), CNTN2(2), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(4), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-E(2), HLA-F(2), ICAM1(1), ICOS(2), ICOSLG(1), ITGA4(2), ITGA6(4), ITGA9(2), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(4), ITGB2(1), ITGB7(3), ITGB8(1), JAM3(1), L1CAM(5), MPZL1(1), NCAM1(1), NCAM2(2), NEGR1(2), NEO1(2), NFASC(5), NRCAM(3), NRXN1(7), NRXN2(4), NRXN3(4), OCLN(2), PTPRC(6), PTPRF(4), PTPRM(3), PVRL2(3), PVRL3(2), SDC3(1), SELE(5), SELP(2), SELPLG(2), SIGLEC1(3), SPN(1), VCAM1(3), VCAN(7) 92698422 204 143 199 68 18 27 27 86 46 0 0.845 1.000 1.000 524 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), CANT1(1), ENPP3(1), ENTPD2(1), ENTPD5(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(1), NME7(1), NPR1(4), NPR2(4), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT5(3), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(5), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(1), PDE8A(2), PDE8B(1), PDE9A(8), PFAS(2), PKM2(1), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(3), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(4), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RFC5(1), RRM1(3), RRM2(1), XDH(6) 107731605 204 138 190 38 15 27 20 76 66 0 0.0474 1.000 1.000 525 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), ATF4(2), CACNA1C(10), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(1), GNAS(4), GRB2(2), HRAS(1), ITPR1(4), ITPR2(10), ITPR3(4), JUN(2), KRAS(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK9(2), MMP14(1), MMP2(7), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLD1(3), PLD2(7), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCD(3), PTK2B(3), RAF1(1), SOS1(6), SOS2(3), SRC(2) 84485985 200 138 195 47 26 28 21 85 40 0 0.0740 1.000 1.000 526 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(2), CREBBP(6), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), CTNND1(5), EGFR(10), EP300(11), ERBB2(4), FARP2(2), FER(2), FGFR1(5), FYN(2), IGF1R(1), INSR(6), IQGAP1(5), LEF1(1), LMO7(11), MAP3K7(1), MAPK3(1), MET(6), MLLT4(8), PARD3(5), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(4), PTPRJ(7), PTPRM(3), PVRL2(3), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(2), WASF3(3), WASL(6), YES1(1) 78785612 186 135 168 46 19 20 26 70 51 0 0.340 1.000 1.000 527 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), DRD1(1), DRD2(1), EGF(4), EGFR(10), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(2), GRM1(5), GRM5(8), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), PDGFC(1), PDGFD(2), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), SOS1(6), SOS2(3), SRC(2), TJP1(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1) 85841526 195 132 190 47 21 26 20 80 48 0 0.245 1.000 1.000 528 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(6), CAPN5(1), CAPN6(2), CAPN7(1), CAPN9(2), CAV2(1), CDC42(1), CSK(3), DOCK1(1), FYN(2), GIT2(2), GRB2(2), ILK(4), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), ITGAD(9), ITGAE(6), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K3(3), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(1), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAPGEF1(4), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(2), SHC1(3), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(7), TNS1(7), VAV2(4), VCL(2), ZYX(1) 88189962 186 131 177 53 11 31 21 72 51 0 0.632 1.000 1.000 529 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(3), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(4), MYBPC3(1), MYH3(6), MYH6(4), MYH7(8), MYH8(5), MYL1(3), MYL2(1), MYL9(1), MYOM1(5), NEB(13), TMOD1(5), TNNI1(1), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TTN(92), VIM(1) 93467529 171 130 167 47 16 32 15 69 36 3 0.385 1.000 1.000 530 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(5), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), ATM(16), ATR(7), BUB1B(1), BUB3(1), CCNA1(8), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNH(1), CDC14A(5), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(2), CDC27(2), CDC6(1), CDC7(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(6), CUL1(3), E2F1(1), EP300(11), ESPL1(8), FZR1(4), GSK3B(3), HDAC1(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(11), RB1(2), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), WEE1(1), YWHAE(1) 89635213 191 129 177 44 11 25 23 68 63 1 0.171 1.000 1.000 531 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), AKAP1(2), AKAP10(1), AKAP11(2), AKAP12(5), AKAP3(1), AKAP4(3), AKAP6(5), AKAP7(1), AKAP8(2), AKAP9(19), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA12(1), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(2), GNB1(2), GNB3(2), GNB5(2), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(4), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(5), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE8A(2), PDE8B(1), PLCB3(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), PRKD1(3), PRKD3(3), SLC9A1(2), USP5(2) 76969295 180 125 174 39 20 22 7 77 53 1 0.135 1.000 1.000 532 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(5), ASH2L(2), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(4), EZH1(2), EZH2(4), FBXO11(3), HCFC1(6), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(4), MEN1(1), MLL(5), MLL2(11), MLL3(15), MLL4(3), MLL5(6), NSD1(8), OGT(4), PAXIP1(1), PRDM2(1), PRDM6(1), PRDM7(4), PRDM9(3), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(2), SETD1A(4), SETD1B(1), SETD7(1), SETDB1(6), SETMAR(2), SMYD3(2), SUV39H2(4), SUV420H1(2), SUZ12(5), WHSC1(5), WHSC1L1(5) 75908148 157 124 156 39 9 23 21 53 51 0 0.302 1.000 1.000 533 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(2), ARHGAP5(4), BCAR1(3), CD99(1), CDC42(1), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CTNNA1(4), CTNNA2(5), CTNNA3(2), CTNNB1(1), CTNND1(5), CXCR4(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), ITK(2), JAM3(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(8), MMP2(7), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), MYLPF(3), NCF1(1), NCF2(1), NOX1(6), NOX3(4), OCLN(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), SIPA1(1), VAV1(3), VAV2(4), VCAM1(3), VCL(2) 79737708 176 124 166 52 20 23 18 59 56 0 0.665 1.000 1.000 534 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(2), CACNA1A(5), CRHR1(1), GNA12(1), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(2), GRID2(6), GRM1(5), GRM5(8), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HRAS(1), IGF1R(1), ITPR1(4), ITPR2(10), ITPR3(4), KRAS(1), MAPK3(1), NOS1(9), NOS3(3), NPR1(4), NPR2(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), RYR1(13) 72272749 161 123 158 49 26 17 13 66 38 1 0.663 1.000 1.000 535 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(4), NPR2(4), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(2), PDE8A(2), PDE9A(8), PFAS(2), PKM2(1), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(4), POLR2I(1), POLRMT(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RRM1(3), RRM2(1) 83661134 173 123 162 31 17 20 16 66 54 0 0.0441 1.000 1.000 536 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR6(1), CCR9(1), CHML(1), CHRM2(3), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(2), GPR174(2), GPR35(2), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(1), GPR85(2), GPR87(1), GRPR(1), HCRTR2(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(2), OPRD1(2), OPRM1(3), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(2), OR8B8(2), P2RY1(1), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(2) 74811985 145 117 143 51 26 18 15 59 27 0 0.651 1.000 1.000 537 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(4), ABCA12(9), ABCA13(18), ABCA2(3), ABCA3(3), ABCA4(7), ABCA5(7), ABCA6(3), ABCA7(7), ABCA8(4), ABCA9(3), ABCB1(4), ABCB11(3), ABCB4(5), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(8), ABCC10(4), ABCC11(5), ABCC12(3), ABCC2(1), ABCC3(10), ABCC4(5), ABCC5(4), ABCC6(5), ABCC8(4), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(5), ABCG5(2), ABCG8(3), CFTR(5), TAP2(1) 77455409 168 117 157 44 6 30 20 68 43 1 0.281 1.000 1.000 538 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 BID(1), BRAF(2), CD48(1), FAS(1), FASLG(1), FCGR3B(1), FYN(2), GRB2(2), HCST(1), HLA-B(1), HLA-C(2), HLA-E(2), HRAS(1), ICAM1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(3), IFNGR1(2), IFNGR2(2), ITGAL(5), ITGB2(1), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(2), NCR1(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SYK(1), TNFRSF10C(1), TNFSF10(6), ULBP2(1), ULBP3(1), VAV1(3), VAV2(4) 71178417 160 117 151 45 10 25 20 60 44 1 0.673 1.000 1.000 539 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(2), ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(2), ALG8(2), B3GNT1(1), B3GNT2(3), B3GNT6(1), B3GNT7(1), B4GALT3(2), B4GALT4(3), B4GALT5(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(1), CHST4(1), CHST7(1), CHSY1(9), DPAGT1(5), EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(1), GALNT1(1), GALNT10(5), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(2), NDST2(3), NDST4(5), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(3), WBSCR17(4), XYLT1(2), XYLT2(2) 70053130 168 115 151 44 6 28 16 57 61 0 0.591 1.000 1.000 540 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(5), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(2), ENPP3(1), EP400(8), ERCC2(1), ERCC3(1), G6PC(3), GAA(1), GANC(2), GBA(2), GBA3(2), GBE1(1), GPI(3), GUSB(7), GYS1(3), GYS2(1), HK1(4), IFIH1(2), MGAM(6), MOV10L1(5), NUDT5(3), PYGB(2), PYGL(1), PYGM(3), RAD54L(2), RUVBL2(2), SETX(7), SI(6), SMARCA2(5), SMARCA5(1), UGP2(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UXS1(1) 81764248 152 114 144 53 7 25 23 45 52 0 0.913 1.000 1.000 541 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BMPR1B(1), BMPR2(5), CHRD(3), CREBBP(6), CUL1(3), DCN(3), E2F5(1), EP300(11), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(2), MAPK3(1), MYC(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(2), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(1), SMAD5(1), SMAD9(1), SMURF2(3), SP1(2), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(11), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(6) 63765341 147 111 133 32 9 13 17 59 49 0 0.308 1.000 1.000 542 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(4), ADCY3(4), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(9), ADCY9(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(3), CREBBP(6), CTNNB1(1), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(11), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GSK3B(3), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), POMC(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), TCF7L2(1), TYR(5), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 68695131 147 110 141 33 15 14 16 69 33 0 0.139 1.000 1.000 543 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), ACVR1B(4), AKT1(2), AURKB(1), BMPR2(5), CDKL1(1), CDS2(1), CLK1(4), CLK2(2), CLK4(3), COL4A3BP(2), CSNK2A2(1), CSNK2B(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(3), MOS(1), NEK1(3), NEK3(3), OCRL(2), PAK4(2), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCG1(2), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(5), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(2), PRKD1(3), PRKG1(3), RAF1(1), RPS6KA1(7), RPS6KA4(1), RPS6KB1(2), STK11(1) 73188644 148 110 141 37 11 23 8 56 49 1 0.472 1.000 1.000 544 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(5), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(2), ARHGEF7(5), BCAR1(3), BRAF(2), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(2), FYN(2), GRB2(2), GRB7(2), GRLF1(6), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(2), MAP2K7(1), MAP3K11(2), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CB(3), PLCG1(2), PLCG2(2), PTK2(1), RAF1(1), RALA(2), RHO(1), ROCK1(4), ROCK2(3), SHC1(3), SOS1(6), SOS2(3), SRC(2), TLN1(7), TLN2(9), ZYX(1) 77961831 163 110 157 41 8 31 18 59 46 1 0.342 1.000 1.000 545 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM2(1), CDS2(1), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(2), INPP5E(2), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), OCRL(2), PI4KA(9), PI4KB(3), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3C3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(2), PTPMT1(2), SYNJ1(5), SYNJ2(6) 80459713 149 108 142 46 14 24 12 56 42 1 0.741 1.000 1.000 546 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(1), CLK2(2), CLK3(1), CLK4(3), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(4), CPSF4(2), CSTF2T(1), CSTF3(4), DDX1(1), DDX20(4), DHX15(3), DHX16(1), DHX8(2), DHX9(4), DICER1(3), FUS(6), GIPC1(1), LSM7(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(3), POLR2A(8), PPM1G(1), PRPF3(2), PRPF4B(3), PRPF8(12), PSKH1(2), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(7), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(2), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(2), SUPT5H(6), TXNL4A(1), U2AF2(2), XRN2(3) 69462013 136 108 133 35 7 34 11 52 31 1 0.306 1.000 1.000 547 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(5), ABL2(5), AKT1(2), AKT2(3), AKT3(2), BRAF(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(10), ELK1(1), ERBB2(4), ERBB3(6), ERBB4(7), GAB1(1), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NCK1(1), NRG1(4), NRG2(3), NRG3(2), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), RAF1(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SOS1(6), SOS2(3), SRC(2), STAT5A(2), STAT5B(2) 65348562 148 107 140 30 12 25 20 56 34 1 0.0807 1.000 1.000 548 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 ABL1(5), ATM(16), BUB1B(1), BUB3(1), CCNA1(8), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(5), CDC20(1), CDC25A(1), CDC25B(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(2), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), DTX4(4), E2F1(1), E2F5(1), EP300(11), ESPL1(8), GSK3B(3), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(11), PTPRA(3), RB1(2), SKP2(1), SMAD4(1), TBC1D8(1), WEE1(1) 72573461 154 103 142 39 10 21 24 50 48 1 0.230 1.000 1.000 549 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(16), CCNA1(8), CCND2(1), CCNE1(2), CCNE2(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(3), E2F1(1), E2F5(1), GBA2(4), MCM2(6), MCM5(2), MCM6(3), MCM7(5), MNAT1(1), MYC(1), MYT1(2), NACA(10), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(2), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(5), WEE1(1) 48457627 114 82 100 27 6 12 12 40 44 0 0.534 1.000 1.000 550 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(2), AKT2(3), AKT3(2), CASP9(1), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(8), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NOS3(3), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PPP3R2(2), PRKCA(2), PRKCG(2), PTGS2(4), PTK2(1), PXN(1), RAC1(1), RAC3(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(1), SRC(2) 44874462 96 77 90 31 7 14 9 44 22 0 0.745 1.000 1.000 551 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), IPMK(1), ITPK1(1), ITPKA(1), ITPKB(1), MINPP1(1), MIOX(2), OCRL(2), PI4KA(9), PI4KB(3), PIK3C3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PTPMT1(2), SYNJ1(5), SYNJ2(6) 46425421 94 76 89 29 8 12 7 35 31 1 0.847 1.000 1.000 552 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(2), GAB2(1), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(1), LCP2(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCD(3), PRKCE(2), RAC1(1), RAC3(1), RAF1(1), SOS1(6), SOS2(3), SYK(1), VAV1(3), VAV2(4) 45962800 85 76 82 28 8 16 12 36 13 0 0.619 1.000 1.000 553 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA2(1), APOA5(2), AQP7(3), CPT1A(1), CPT1C(4), CPT2(1), CYP27A1(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(5), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(1), HMGCS2(1), ILK(4), LPL(2), ME1(1), MMP1(1), NR1H3(3), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(6), SORBS1(1), UBC(3), UCP1(1) 41198276 96 75 89 30 6 12 14 36 28 0 0.795 1.000 1.000 554 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(1), CSK(3), EGFR(10), F11R(1), GIT1(2), IGSF5(4), IKBKB(1), JAM3(1), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(2), PLCG2(2), PTPN11(1), PTPRZ1(10), RAC1(1), RELA(5), SRC(2), TJP1(2) 46433030 94 71 84 23 6 14 11 35 27 1 0.522 1.000 1.000 555 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNB1(3), MAP2K7(1), MAP3K1(6), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(3), PAK2(2), PRKCD(3), PRKDC(11), PSEN2(3), PTK2(1), RASA1(3), RB1(2), RELA(5), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1) 45462088 87 67 84 22 3 19 11 31 22 1 0.303 1.000 1.000 556 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(5), ATP4A(5), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), COX10(2), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB2(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), NDUFV2(1), NDUFV3(2), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1) 36695426 79 67 78 26 5 11 11 35 17 0 0.803 1.000 1.000 557 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(5), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(2), EP400(8), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(5), NUDT5(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(7), SMARCA2(5), SMARCA5(1) 40685480 81 67 78 23 2 19 11 21 28 0 0.438 1.000 1.000 558 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(7), AXIN1(3), CCND2(1), CTNNB1(1), DVL1(1), DVL2(1), FZD1(2), FZD10(3), FZD2(2), FZD3(1), FZD5(1), GSK3B(3), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1) 37193972 72 64 69 22 6 13 7 27 19 0 0.564 1.000 1.000 559 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(4), AOC3(1), ARG1(1), ASL(4), CPS1(5), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(1), NOS1(9), NOS3(3), OAT(1), ODC1(2), OTC(1), P4HA1(3), P4HA2(1), P4HA3(1), PYCR1(1), RARS(2), SMS(2) 28582659 68 60 66 20 3 5 14 26 20 0 0.663 1.000 1.000 560 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(6), EEF1A2(1), EEF1D(1), EEF1G(1), EEF2K(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(3), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(10), PABPC3(7), PAIP1(3), SLC35A4(2) 28841964 68 60 68 23 8 11 9 24 16 0 0.712 1.000 1.000 561 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(2), MCM2(6), MCM5(2), MCM6(3), MCM7(5), NACA(10), ORC1L(1), ORC2L(1), PCNA(3), POLD1(6), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(5), RFC2(1), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBB(1), UBC(3) 33302474 72 58 64 22 5 8 7 26 26 0 0.825 1.000 1.000 562 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 ABO(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(1), FUT6(2), GBGT1(2), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(5), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 29539783 70 58 65 20 7 10 7 19 26 1 0.687 1.000 1.000 563 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(2), CARS(6), CARS2(3), DARS(1), DARS2(1), EPRS(3), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(3), KARS(1), LARS(3), LARS2(2), MARS(2), MARS2(3), NARS2(4), PARS2(3), QARS(1), RARS(2), SARS(3), TARS(6), TARS2(5), VARS(2), VARS2(2), WARS(1), WARS2(4), YARS(1) 34829011 73 57 67 19 1 12 8 33 19 0 0.500 1.000 1.000 564 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(3), GAA(1), GBA3(2), GBE1(1), GPI(3), GUSB(7), GYS1(3), GYS2(1), HK1(4), MGAM(6), PYGB(2), PYGL(1), PYGM(3), RNPC3(1), SI(6), UCHL3(1), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1) 37840880 68 57 63 24 5 9 11 21 22 0 0.848 1.000 1.000 565 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(4), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(4), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADHA(2), MAOA(1), TPH1(1), WARS(1), WARS2(4) 35913132 73 57 66 22 6 12 8 30 17 0 0.630 1.000 1.000 566 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1C1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(2), UGT1A1(1), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3) 38058446 69 55 65 20 7 8 9 25 20 0 0.665 1.000 1.000 567 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(3), F13B(2), F2(3), F5(8), F7(1), F8(5), F9(2), FGA(2), FGG(5), LPA(6), PLAT(4), PLAU(4), PLG(5), SERPINF2(2), VWF(11) 22827589 64 54 60 21 4 4 11 24 19 2 0.740 1.000 1.000 568 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(4), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 33048574 71 54 70 29 4 17 10 23 17 0 0.953 1.000 1.000 569 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(4), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 33048574 71 54 70 29 4 17 10 23 17 0 0.953 1.000 1.000 570 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(6), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK2(2), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(2), PPP3CC(3), RAF1(1), SHC1(3), SOS1(6), SYK(1), SYT1(1), VAV1(3) 26213157 59 52 56 17 6 9 4 20 20 0 0.650 1.000 1.000 571 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(6), MAPK14(1), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SYK(1), SYT1(1), VAV1(3) 24547456 57 49 54 20 6 9 4 19 19 0 0.858 1.000 1.000 572 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(7), CREBBP(6), EP300(11), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(7), NRIP1(6), PELP1(1), POLR2A(8), SRA1(1), TBP(1) 30162873 58 49 55 16 2 7 10 22 17 0 0.476 1.000 1.000 573 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ASL(4), ASS1(2), CPS1(5), DAO(1), EPRS(3), GATM(2), GOT1(3), GOT2(2), LAP3(2), NOS1(9), NOS3(3), OAT(1), OTC(1), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), PYCR2(1), RARS(2) 23285057 53 48 53 16 3 4 12 21 13 0 0.645 1.000 1.000 574 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), ATP8A1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR77(1), GRPR(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(3), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2), TSHR(2) 32739361 60 48 60 23 15 7 5 23 10 0 0.686 1.000 1.000 575 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(2), CBL(2), CFLAR(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(4), JAK1(5), JAK3(3), MAPK3(1), MYC(1), PIK3R1(2), PTPN6(3), RAF1(1), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(6), STAT5A(2), STAT5B(2), SYK(1) 21477159 51 47 50 15 6 9 7 16 13 0 0.542 1.000 1.000 576 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(2), EIF1(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), FLT1(9), FLT4(7), HIF1A(3), HRAS(1), KDR(5), NOS3(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PXN(1), SHC1(3) 20668553 51 46 50 16 5 6 5 19 16 0 0.788 1.000 1.000 577 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PIK3R1(2), PTK2(1), PXN(1), RAF1(1), ROCK1(4), SHC1(3), SRC(2), TLN1(7) 23089300 48 44 47 14 4 8 2 18 16 0 0.681 1.000 1.000 578 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), AR(1), ESR2(2), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(2), NR4A2(1), NR5A2(2), PGR(2), PPARD(1), PPARG(2), RARA(4), RARB(3), RORA(2), RORC(1), RXRB(4), RXRG(2), THRA(2), VDR(1) 26236564 46 44 46 16 6 6 11 15 8 0 0.710 1.000 1.000 579 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(5), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(4) 21376454 46 43 43 18 2 6 8 19 11 0 0.919 1.000 1.000 580 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDS2(1), CHAT(4), CHKB(2), CLC(2), DGKA(2), DGKB(2), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(3), PLCB2(2), PLCG1(2), PLCG2(2), PPAP2B(1), PPAP2C(2) 32534496 49 42 45 18 6 10 4 13 16 0 0.804 1.000 1.000 581 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 DOCK1(1), ELK1(1), FOS(1), GAB1(1), GRB2(2), HGF(1), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAP4K1(2), MAPK3(1), MET(6), PAK1(2), PIK3R1(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(3) 27699494 54 42 52 18 4 13 2 19 16 0 0.849 1.000 1.000 582 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(3), G6PC(3), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(3), GANC(2), GLA(1), GLB1(5), HK1(4), LALBA(1), LCT(2), MGAM(6), PFKL(1), PFKM(3), PFKP(2), RDH11(3), UGP2(1) 24901001 47 41 46 14 5 6 7 14 15 0 0.624 1.000 1.000 583 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(2), BAX(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), FAS(1), FASLG(1), JUN(2), MAP3K1(6), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(3), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFSF10(6), TRADD(2), TRAF2(1) 23497523 47 40 41 15 0 8 7 15 16 1 0.820 1.000 1.000 584 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(10), PDK2(2), PIK3R1(2), PRKCA(2), RPS6KB1(2) 16318161 41 38 41 14 6 9 4 16 6 0 0.687 1.000 1.000 585 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(1), ADCY3(4), ADCY9(4), ARF1(1), ARF3(1), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ATP6V1G1(1), ERO1L(1), GNAS(4), PLCG1(2), PLCG2(2), PRKCA(2), SEC61B(1), TRIM23(3) 24292078 43 38 42 17 1 6 5 17 14 0 0.970 1.000 1.000 586 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(3), JAK1(5), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(6), SRF(1), STAT3(3) 15363821 41 38 41 13 3 4 6 18 10 0 0.815 1.000 1.000 587 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GRB2(2), HRAS(1), JUN(2), MAP2K3(3), MAP3K1(6), MAPK14(1), MAPK3(1), PAK1(2), PLCG1(2), PRKCA(2), PTK2B(3), RAC1(1), RAF1(1), SHC1(3), SOS1(6), SRC(2), SYT1(1) 18578940 43 38 42 13 4 9 1 18 11 0 0.767 1.000 1.000 588 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(1), AKT1(2), DGKA(2), GCA(2), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(4), ITPR2(10), ITPR3(4), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(4), PDE3B(1), PIK3C2G(3), PIK3CD(1), PIK3R1(2) 30707028 44 37 44 15 6 7 4 19 8 0 0.623 1.000 1.000 589 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(2), PIK3C2A(3), PIK3C2B(3), PIK3C2G(3), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(6), PLCD1(1), PLCG1(2), PLCG2(2) 28177340 44 36 42 19 2 3 2 22 15 0 0.993 1.000 1.000 590 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(2), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS9(1) 14457472 39 35 39 10 2 3 8 19 7 0 0.501 1.000 1.000 591 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), G6PC(3), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(3), GLA(1), GLB1(5), HK1(4), LALBA(1), LCT(2), MGAM(6), PFKM(3), PFKP(2) 21050291 37 33 36 14 3 5 5 10 14 0 0.881 1.000 1.000 592 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), IL22RA1(1), IL22RA2(1), JAK1(5), JAK2(5), JAK3(3), SOCS3(1), STAT1(4), STAT3(3), STAT5A(2), STAT5B(2), TYK2(6) 11937463 34 33 32 13 1 0 6 14 13 0 0.975 1.000 1.000 593 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(5), JAK3(3), JUN(2), MAPK3(1), RAF1(1), SHC1(3), SOS1(6), STAT5A(2), STAT5B(2), SYK(1) 15080632 35 33 34 11 4 5 4 14 8 0 0.723 1.000 1.000 594 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(4) 18605266 36 32 36 11 6 9 1 15 5 0 0.414 1.000 1.000 595 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(6), EP300(11), FYN(2), JAK1(5), JAK3(3), PIK3R1(2), PTK2B(3), STAT5A(2), STAT5B(2) 16897303 36 32 32 11 1 5 7 12 11 0 0.744 1.000 1.000 596 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(5), ITGB1(4), ITGB3(1), PTK2(1), PXN(1), RAC1(1), SPTAN1(6), SRC(2), TLN1(7) 18685380 35 32 34 12 3 4 1 14 13 0 0.891 1.000 1.000 597 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(14), SCARB1(2), SOAT1(4) 17613083 32 31 30 10 2 7 4 10 9 0 0.592 1.000 1.000 598 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 AKR1B1(3), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(4), KHK(5), MPI(2), PFKFB3(1), PFKM(3), PFKP(2), PMM1(1), TPI1(1) 15263040 32 30 32 13 4 2 5 9 12 0 0.918 1.000 1.000 599 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRB2(2), CHRM2(3), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2) 15949244 33 30 31 15 5 3 2 14 9 0 0.908 1.000 1.000 600 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), SLC23A1(5), SLC23A2(1), SLC2A1(1), SLC2A3(2) 16805555 30 29 30 12 3 10 2 9 6 0 0.772 1.000 1.000 601 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(4), GNB1(2), HRAS(1), LIMK1(4), MAPK3(1), MYL2(1), NOX1(6), PIK3C2G(3), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2(1), RAF1(1), ROCK2(3) 16827317 32 28 28 12 1 3 1 15 12 0 0.982 1.000 1.000 602 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(7), CD2(2), CD33(1), IFNA1(2), IFNB1(3), IL3(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(4), TLR9(1) 11884722 29 28 28 10 2 6 6 10 5 0 0.701 1.000 1.000 603 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(2), AKT1(2), ASAH1(2), GNAI1(1), GNB1(2), ITGAV(1), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3R1(2), PLCB1(1), PRKCA(2), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2) 16565015 31 28 31 15 2 7 2 12 8 0 0.953 1.000 1.000 604 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(6), SRF(1) 14318494 30 28 30 11 6 8 1 12 3 0 0.692 1.000 1.000 605 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(2), ANXA4(1), ANXA6(2), CYP11A1(1), EDNRB(3), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), PTGS1(2), PTGS2(4), TBXAS1(3) 13322619 28 28 28 16 2 4 4 10 7 1 0.983 1.000 1.000 606 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1) 13047876 31 27 28 11 2 5 2 7 15 0 0.901 1.000 1.000 607 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), PLA2G4A(1), PLCB1(1), PRKCA(2), PTGS1(2), PTK2(1), RAF1(1), SRC(2), SYK(1), TBXAS1(3) 16063605 31 27 30 15 2 5 3 8 12 1 0.972 1.000 1.000 608 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR1(2), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(8), COL4A6(4), REN(1) 16834151 28 26 28 11 3 10 3 7 5 0 0.685 1.000 1.000 609 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(3), CTNNA1(4), CTNNA2(5), CTNNB1(1), PTK2(1), PXN(1), SRC(2), VCL(2) 12436358 27 26 27 13 5 4 3 12 3 0 0.931 1.000 1.000 610 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(7), G6PD(2), GCLC(1), GGT1(2), GPX1(1), GPX3(3), GPX4(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(2), IDH1(2), IDH2(5) 11898082 29 26 26 11 1 2 6 12 8 0 0.937 1.000 1.000 611 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(5) 16952399 30 25 26 16 1 6 1 12 9 1 0.994 1.000 1.000 612 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(5), GALNT2(2), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 9626314 23 22 20 14 1 1 6 6 9 0 0.997 1.000 1.000 613 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2) 3749783 6 6 6 5 1 3 0 2 0 0 0.859 1.000 1.000 614 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2) 3749783 6 6 6 5 1 3 0 2 0 0 0.859 1.000 1.000 615 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 1058489 1 1 1 2 0 0 1 0 0 0 0.982 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 341605 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000