Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	258.0	2071.0	8.0	-0.841	0.217	1000.0	-1000.0	-0.042	-1000.0
HIF-1-alpha transcription factor network	201.0	15296.0	76.0	-1.33	0.026	1000.0	-1000.0	-0.179	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	183.0	6222.0	34.0	-0.605	0.016	1000.0	-1000.0	-0.109	-1000.0
TCR signaling in naïve CD8+ T cells	148.0	13797.0	93.0	-0.655	0.328	1000.0	-1000.0	-0.113	-1000.0
TCGA08_p53	146.0	1027.0	7.0	-0.652	0.313	1000.0	-1000.0	-0.019	-1000.0
Syndecan-4-mediated signaling events	120.0	8066.0	67.0	-0.638	0.108	1000.0	-1000.0	-0.138	-1000.0
Aurora B signaling	119.0	8035.0	67.0	-0.404	0.016	1000.0	-1000.0	-0.106	-1000.0
FOXA2 and FOXA3 transcription factor networks	117.0	5395.0	46.0	-1.219	0.025	1000.0	-1000.0	-0.095	-1000.0
IL12-mediated signaling events	116.0	10111.0	87.0	-0.69	0.162	1000.0	-1000.0	-0.141	-1000.0
Glypican 1 network	106.0	5123.0	48.0	-0.557	0.045	1000.0	-1000.0	-0.078	-1000.0
FOXM1 transcription factor network	105.0	5382.0	51.0	-0.823	0.04	1000.0	-1000.0	-0.205	-1000.0
PDGFR-alpha signaling pathway	104.0	4618.0	44.0	-0.274	0.034	1000.0	-1000.0	-0.096	-1000.0
amb2 Integrin signaling	84.0	6888.0	82.0	-0.55	0.016	1000.0	-1000.0	-0.124	-1000.0
IL4-mediated signaling events	78.0	7117.0	91.0	-0.838	0.544	1000.0	-1000.0	-0.168	-1000.0
Caspase cascade in apoptosis	77.0	5751.0	74.0	-0.325	0.161	1000.0	-1000.0	-0.093	-1000.0
JNK signaling in the CD4+ TCR pathway	77.0	1318.0	17.0	-0.412	0.016	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	74.0	1567.0	21.0	-0.666	0.016	1000.0	-1000.0	-0.111	-1000.0
Aurora C signaling	71.0	499.0	7.0	-0.393	0.012	1000.0	-1000.0	-0.064	-1000.0
VEGFR1 specific signals	71.0	3991.0	56.0	-0.467	0.046	1000.0	-1000.0	-0.115	-1000.0
Glypican 2 network	70.0	281.0	4.0	-0.123	-1000.0	1000.0	-1000.0	-0.052	-1000.0
Syndecan-1-mediated signaling events	67.0	2303.0	34.0	-0.413	0.016	1000.0	-1000.0	-0.108	-1000.0
BMP receptor signaling	63.0	5108.0	81.0	-0.689	0.016	1000.0	-1000.0	-0.13	-1000.0
HIF-2-alpha transcription factor network	61.0	2637.0	43.0	-0.76	0.34	1000.0	-1000.0	-0.121	-1000.0
IL23-mediated signaling events	61.0	3673.0	60.0	-0.392	0.021	1000.0	-1000.0	-0.186	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	61.0	2013.0	33.0	-0.83	0.016	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by the Hedgehog family	51.0	2691.0	52.0	-0.436	0.118	1000.0	-1000.0	-0.111	-1000.0
Fc-epsilon receptor I signaling in mast cells	48.0	4663.0	97.0	-0.32	0.04	1000.0	-1000.0	-0.129	-1000.0
IL27-mediated signaling events	45.0	2319.0	51.0	-0.622	0.074	1000.0	-1000.0	-0.096	-1000.0
S1P1 pathway	43.0	1551.0	36.0	-0.378	0.018	1000.0	-1000.0	-0.092	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	42.0	2877.0	68.0	-0.545	0.063	1000.0	-1000.0	-0.174	-1000.0
Ephrin A  reverse signaling	41.0	292.0	7.0	-0.059	-0.0	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	41.0	1091.0	26.0	-0.363	0.016	1000.0	-1000.0	-0.092	-1000.0
Arf6 signaling events	40.0	2485.0	62.0	-0.666	0.016	1000.0	-1000.0	-0.086	-1000.0
Calcium signaling in the CD4+ TCR pathway	38.0	1194.0	31.0	-0.455	0.016	1000.0	-1000.0	-0.155	-1000.0
p75(NTR)-mediated signaling	36.0	4581.0	125.0	-0.414	0.016	1000.0	-1000.0	-0.149	-1000.0
IL2 signaling events mediated by PI3K	35.0	2030.0	58.0	-0.432	0.032	1000.0	-1000.0	-0.108	-1000.0
LPA4-mediated signaling events	34.0	417.0	12.0	-0.165	0.026	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by STAT5	34.0	751.0	22.0	-0.435	0.038	1000.0	-1000.0	-0.081	-1000.0
Coregulation of Androgen receptor activity	31.0	2356.0	76.0	-0.915	0.033	1000.0	-1000.0	-0.073	-1000.0
PLK1 signaling events	31.0	2656.0	85.0	-0.376	0.016	1000.0	-1000.0	-0.08	-1000.0
Integrins in angiogenesis	31.0	2613.0	84.0	-0.378	0.04	1000.0	-1000.0	-0.132	-1000.0
BCR signaling pathway	31.0	3154.0	99.0	-0.343	0.035	1000.0	-1000.0	-0.14	-1000.0
Glucocorticoid receptor regulatory network	30.0	3429.0	114.0	-0.408	0.162	1000.0	-1000.0	-0.098	-1000.0
Regulation of Telomerase	30.0	3129.0	102.0	-0.667	0.051	1000.0	-1000.0	-0.139	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	29.0	2279.0	78.0	-0.316	0.045	1000.0	-1000.0	-0.111	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	28.0	1541.0	54.0	-0.65	0.031	1000.0	-1000.0	-0.132	-1000.0
EPO signaling pathway	28.0	1566.0	55.0	-0.286	0.018	1000.0	-1000.0	-0.132	-1000.0
IL6-mediated signaling events	27.0	2091.0	75.0	-0.287	0.076	1000.0	-1000.0	-0.127	-1000.0
Reelin signaling pathway	24.0	1392.0	56.0	-0.238	0.016	1000.0	-1000.0	-0.121	-1000.0
Visual signal transduction: Rods	24.0	1256.0	52.0	-0.288	0.016	1000.0	-1000.0	-0.122	-1000.0
Signaling events mediated by PTP1B	23.0	1765.0	76.0	-0.669	0.049	1000.0	-1000.0	-0.116	-1000.0
Angiopoietin receptor Tie2-mediated signaling	23.0	2094.0	88.0	-0.312	0.075	1000.0	-1000.0	-0.157	-1000.0
Aurora A signaling	22.0	1323.0	60.0	-0.238	0.053	1000.0	-1000.0	-0.107	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	22.0	1005.0	45.0	-0.566	0.062	1000.0	-1000.0	-0.128	-1000.0
Syndecan-2-mediated signaling events	21.0	1454.0	69.0	-0.55	0.053	1000.0	-1000.0	-0.104	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2530.0	120.0	-0.164	0.141	1000.0	-1000.0	-0.112	-1000.0
Endothelins	18.0	1780.0	96.0	-0.347	0.086	1000.0	-1000.0	-0.101	-1000.0
Wnt signaling	18.0	127.0	7.0	-0.068	0.016	1000.0	-1000.0	-0.085	-1000.0
Class I PI3K signaling events	18.0	1325.0	73.0	-0.472	0.036	1000.0	-1000.0	-0.107	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2404.0	136.0	-0.452	0.1	1000.0	-1000.0	-0.128	-1000.0
Presenilin action in Notch and Wnt signaling	17.0	1039.0	61.0	-0.187	0.092	1000.0	-1000.0	-0.108	-1000.0
S1P3 pathway	17.0	720.0	42.0	-0.374	0.062	1000.0	-1000.0	-0.089	-1000.0
Thromboxane A2 receptor signaling	16.0	1776.0	105.0	-0.666	0.067	1000.0	-1000.0	-0.111	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	16.0	610.0	37.0	-0.294	0.026	1000.0	-1000.0	-0.129	-1000.0
LPA receptor mediated events	16.0	1665.0	102.0	-0.398	0.06	1000.0	-1000.0	-0.126	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	426.0	28.0	-0.138	0.023	1000.0	-1000.0	-0.081	-1000.0
Ceramide signaling pathway	15.0	1164.0	76.0	-0.666	0.232	1000.0	-1000.0	-0.091	-1000.0
FoxO family signaling	15.0	997.0	64.0	-0.569	0.122	1000.0	-1000.0	-0.112	-1000.0
PLK2 and PLK4 events	14.0	44.0	3.0	-0.016	0.011	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.07	-1000.0
IFN-gamma pathway	13.0	887.0	68.0	-0.373	0.018	1000.0	-1000.0	-0.13	-1000.0
FAS signaling pathway (CD95)	13.0	647.0	47.0	-0.422	0.028	1000.0	-1000.0	-0.075	-1000.0
Canonical Wnt signaling pathway	13.0	713.0	51.0	-0.186	0.096	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	13.0	1729.0	125.0	-0.39	0.043	1000.0	-1000.0	-0.148	-1000.0
Regulation of Androgen receptor activity	13.0	932.0	70.0	-0.957	0.04	1000.0	-1000.0	-0.094	-1000.0
Nongenotropic Androgen signaling	12.0	639.0	52.0	-0.177	0.071	1000.0	-1000.0	-0.086	-1000.0
ErbB4 signaling events	11.0	796.0	69.0	-0.179	0.105	1000.0	-1000.0	-0.133	-1000.0
S1P5 pathway	11.0	197.0	17.0	-0.138	0.046	1000.0	-1000.0	-0.074	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	836.0	74.0	-0.666	0.099	1000.0	-1000.0	-0.137	-1000.0
S1P4 pathway	11.0	287.0	25.0	-0.138	0.033	1000.0	-1000.0	-0.075	-1000.0
Visual signal transduction: Cones	9.0	363.0	38.0	-0.041	0.016	1000.0	-1000.0	-0.095	-1000.0
Noncanonical Wnt signaling pathway	9.0	254.0	26.0	-0.115	0.016	1000.0	-1000.0	-0.128	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	-0.02	0.016	1000.0	-1000.0	-0.051	-1000.0
TCGA08_rtk_signaling	9.0	238.0	26.0	-0.276	0.041	1000.0	-1000.0	-0.033	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	692.0	82.0	-0.064	0.025	1000.0	-1000.0	-0.126	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PRL	7.0	245.0	34.0	-0.055	0.045	1000.0	-1000.0	-0.091	-1000.0
Canonical NF-kappaB pathway	6.0	268.0	39.0	-0.187	0.075	1000.0	-1000.0	-0.115	-1000.0
Insulin-mediated glucose transport	6.0	192.0	32.0	-0.083	0.068	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by HDAC Class III	6.0	242.0	40.0	-0.058	0.032	1000.0	-1000.0	-0.066	-1000.0
IL1-mediated signaling events	6.0	400.0	62.0	-0.09	0.059	1000.0	-1000.0	-0.136	-1000.0
Ephrin B reverse signaling	6.0	335.0	48.0	-0.03	0.031	1000.0	-1000.0	-0.104	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	271.0	44.0	-0.046	0.049	1000.0	-1000.0	-0.069	-1000.0
Plasma membrane estrogen receptor signaling	6.0	540.0	86.0	-0.163	0.07	1000.0	-1000.0	-0.131	-1000.0
p38 MAPK signaling pathway	6.0	276.0	44.0	-0.099	0.049	1000.0	-1000.0	-0.101	-1000.0
ErbB2/ErbB3 signaling events	5.0	387.0	65.0	-0.128	0.059	1000.0	-1000.0	-0.103	-1000.0
Arf6 downstream pathway	5.0	225.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.057	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	85.0	15.0	0.0	0.036	1000.0	-1000.0	-0.049	-1000.0
Syndecan-3-mediated signaling events	5.0	209.0	35.0	-0.039	0.016	1000.0	-1000.0	-0.117	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	407.0	76.0	-0.026	0.067	1000.0	-1000.0	-0.122	-1000.0
Arf6 trafficking events	5.0	413.0	71.0	-0.123	0.058	1000.0	-1000.0	-0.106	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	85.0	17.0	-0.037	0.055	1000.0	-1000.0	-0.064	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	363.0	85.0	-0.037	0.079	1000.0	-1000.0	-0.108	-1000.0
EPHB forward signaling	4.0	376.0	85.0	-0.075	0.069	1000.0	-1000.0	-0.137	-1000.0
BARD1 signaling events	3.0	217.0	57.0	-0.166	0.044	1000.0	-1000.0	-0.102	-1000.0
Osteopontin-mediated events	3.0	123.0	38.0	-0.03	0.096	1000.0	-1000.0	-0.148	-1000.0
Cellular roles of Anthrax toxin	3.0	119.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	138.0	36.0	-0.026	0.031	1000.0	-1000.0	-0.101	-1000.0
PDGFR-beta signaling pathway	3.0	386.0	97.0	-0.058	0.087	1000.0	-1000.0	-0.122	-1000.0
E-cadherin signaling in keratinocytes	3.0	133.0	43.0	-0.291	0.054	1000.0	-1000.0	-0.119	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	134.0	65.0	-0.06	0.093	1000.0	-1000.0	-0.097	-1000.0
ceramide signaling pathway	2.0	131.0	49.0	-0.116	0.054	1000.0	-1000.0	-0.074	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	119.0	52.0	-0.031	0.093	1000.0	-1000.0	-0.107	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	181.0	83.0	-0.083	0.081	1000.0	-1000.0	-0.112	-1000.0
Signaling events mediated by HDAC Class I	2.0	216.0	104.0	-0.029	0.063	1000.0	-1000.0	-0.101	-1000.0
Retinoic acid receptors-mediated signaling	2.0	128.0	58.0	-0.025	0.062	1000.0	-1000.0	-0.112	-1000.0
Regulation of p38-alpha and p38-beta	2.0	150.0	54.0	-0.041	0.073	1000.0	-1000.0	-0.094	-1000.0
Insulin Pathway	2.0	200.0	74.0	-0.034	0.055	1000.0	-1000.0	-0.141	-1000.0
Signaling events mediated by HDAC Class II	1.0	127.0	75.0	-0.027	0.051	1000.0	-1000.0	-0.092	-1000.0
Circadian rhythm pathway	1.0	33.0	22.0	-0.019	0.064	1000.0	-1000.0	-0.089	-1000.0
mTOR signaling pathway	1.0	102.0	53.0	-0.01	0.044	1000.0	-1000.0	-0.087	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	103.0	68.0	-0.083	0.059	1000.0	-1000.0	-0.105	-1000.0
Nectin adhesion pathway	1.0	92.0	63.0	-0.016	0.078	1000.0	-1000.0	-0.11	-1000.0
Atypical NF-kappaB pathway	1.0	55.0	31.0	-0.02	0.037	1000.0	-1000.0	-0.105	-1000.0
IGF1 pathway	1.0	110.0	57.0	-0.065	0.071	1000.0	-1000.0	-0.137	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.062	1000.0	-1000.0	-0.111	-1000.0
TRAIL signaling pathway	0.0	32.0	48.0	-0.002	0.07	1000.0	-1000.0	-0.095	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.082	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.006	0.016	1000.0	-1000.0	-0.065	-1000.0
Arf1 pathway	0.0	31.0	54.0	-0.01	0.043	1000.0	-1000.0	-0.078	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.005	0.016	1000.0	-1000.0	-0.107	-1000.0
Total	4180	224701	7203	-39.8860234341	-991.853868918	131000	-131000	-13.6416309817	-131000