rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(2), ADORA3(1), P2RY1(2), P2RY2(1), P2RY6(2) 1424191 8 8 8 0 1 1 2 4 0 0 0.0940 0.0120 1.000 2 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(1), EIF4A2(1), EIF4B(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(4), PIK3CA(2), PIK3R1(2), PTEN(5), TSC1(2), TSC2(4) 6716562 27 24 27 2 2 6 4 6 9 0 0.0233 0.0121 1.000 3 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(2), GCLC(3), GGT1(1), GPX1(1), GPX4(1), GSTA1(1), GSTA2(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), IDH2(1), OPLAH(3) 5431281 21 18 21 0 2 4 5 7 3 0 0.00234 0.0192 1.000 4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CDKN2A(2), E2F2(1), PRB1(2), TP53(4) 2036926 10 9 10 1 0 0 0 6 3 1 0.360 0.0206 1.000 5 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(3), NRG2(1), NRG3(3) 2177146 9 9 9 0 2 1 1 4 1 0 0.0853 0.0239 1.000 6 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(1) 433960 3 3 3 1 1 0 1 1 0 0 0.766 0.0251 1.000 7 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(2), IDH2(1), MDH1(1), OGDH(5), SDHA(2), SUCLA2(1) 2277788 12 11 12 2 0 3 0 4 5 0 0.293 0.0337 1.000 8 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFV1(1) 1698697 9 9 8 2 0 0 1 3 5 0 0.750 0.0416 1.000 9 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(2), GCLC(3), GGT1(1), GPX1(1), GPX4(1), GSTA1(1), GSTA2(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), IDH2(1) 4460585 17 15 17 0 1 3 4 7 2 0 0.00824 0.0438 1.000 10 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(1), RAB3A(1), RAB6A(1) 1030751 5 5 5 1 0 1 1 2 1 0 0.685 0.0445 1.000 11 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(3), AGT(3), AGTR2(1), KNG1(2), NOS3(1) 2443240 10 10 10 1 1 1 1 6 1 0 0.230 0.0474 1.000 12 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(1), DPYS(2), ENPP1(4), ENPP3(1), PANK2(1), PANK3(2), PPCS(1) 3373705 13 12 13 1 2 0 0 6 5 0 0.281 0.0494 1.000 13 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(1), DAG1(3), ITPKA(1), ITPKB(1) 1465809 7 6 7 1 1 0 2 0 4 0 0.693 0.0516 1.000 14 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 122038 1 1 1 0 0 0 0 0 1 0 1.000 0.0604 1.000 15 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(2), ITGAM(3), ITGB2(1), SELE(1), SELL(1) 2555223 9 9 9 0 2 2 0 4 1 0 0.0716 0.0763 1.000 16 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), HADHA(2) 1314125 5 5 5 0 0 1 0 3 0 1 0.331 0.0814 1.000 17 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL10RA(4), JAK1(2), STAT1(1), STAT5A(1), TNF(1) 2954387 10 10 10 1 2 0 0 6 2 0 0.458 0.0842 1.000 18 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), SELE(1), SELL(1) 3887865 12 12 12 1 2 2 1 5 2 0 0.175 0.0867 1.000 19 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), EHHADH(1), HADHA(2) 1176952 5 5 5 1 0 0 1 3 1 0 0.524 0.0940 1.000 20 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(2), AKT3(1), PIK3CA(2), PIK3CD(1), PTEN(5), RBL2(2), SOS1(3) 4925268 17 15 17 2 2 3 3 3 6 0 0.111 0.101 1.000 21 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(1), ITGAL(2), ITGB1(2), ITGB2(1), SELE(1), SELL(1) 2938159 9 9 9 1 1 2 1 3 2 0 0.317 0.101 1.000 22 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(2), ALDH3A2(2), UGDH(1) 2074147 7 7 7 1 1 1 4 1 0 0 0.311 0.101 1.000 23 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(2), OAT(1), PRODH(1) 1369163 5 5 5 1 0 0 2 1 2 0 0.709 0.113 1.000 24 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSL(2), AGXT(1), AGXT2(1), ASNS(1), CAD(4), CRAT(2), DARS(2), DDO(1), GAD1(2), GAD2(1), GPT(2), PC(5) 6335082 25 22 25 3 1 4 2 9 9 0 0.161 0.139 1.000 25 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(2), ENPP1(4), ENPP3(1), FLAD1(1), MTMR2(2), MTMR6(1), PHPT1(1) 3638098 12 11 11 0 0 3 1 7 1 0 0.0552 0.145 1.000 26 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), IL5RA(2) 1287805 4 4 4 0 1 0 1 0 2 0 0.488 0.157 1.000 27 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1B1(2), ALDH2(2), ALDH3A2(2) 1936281 6 6 6 0 1 1 3 1 0 0 0.124 0.162 1.000 28 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1B1(2), ALDH2(2), ALDH3A2(2) 1936281 6 6 6 0 1 1 3 1 0 0 0.124 0.162 1.000 29 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2) 2951017 9 9 9 1 1 1 3 4 0 0 0.202 0.163 1.000 30 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNE1(1), CCNE2(1), CDKN2A(2), E2F2(1), PRB1(2) 2183798 7 6 7 0 0 1 1 2 2 1 0.203 0.172 1.000 31 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(2), DHCR24(1), GGCX(1), HSD17B7(1), IDI2(1), LSS(2), SQLE(1), TM7SF2(2) 4716092 13 12 13 0 2 3 1 5 2 0 0.0252 0.178 1.000 32 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), HLA-A(1), ICAM1(1), ITGAL(2), ITGB2(1) 2110199 6 6 6 1 1 1 0 3 0 1 0.433 0.189 1.000 33 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GBA3(1), GGT1(1), SHMT2(2) 1359590 5 5 5 0 0 0 1 4 0 0 0.329 0.190 1.000 34 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(2), MTMR6(1), PHPT1(1), TPK1(1) 1546101 5 5 5 0 0 2 1 2 0 0 0.211 0.194 1.000 35 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(1), RDH5(2) 933101 3 3 3 1 0 0 3 0 0 0 0.721 0.198 1.000 36 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(1), SHMT2(2) 1024321 4 4 4 0 0 0 1 3 0 0 0.407 0.199 1.000 37 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(4), TNF(1) 1579608 5 5 4 0 1 0 0 1 3 0 0.571 0.203 1.000 38 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(1), DPYS(2), ENPP1(4), ENPP3(1), ILVBL(1), PANK2(1), PANK3(2), PPCS(1) 4196180 14 13 14 2 2 0 1 6 5 0 0.434 0.230 1.000 39 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(1), CASP8AP2(3), CASP9(1), CES1(1) 2700022 10 10 10 2 1 1 4 2 2 0 0.345 0.230 1.000 40 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(1), CSNK1E(3), PER1(1) 2088356 7 7 7 2 2 1 2 2 0 0 0.608 0.233 1.000 41 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLB(1), POLD1(1), POLG(2), POLG2(1), POLK(2), POLM(1), POLQ(5), PRIM1(1), PRIM2(3), REV1(2), REV3L(3), RFC5(2) 9891128 27 26 27 2 0 3 3 13 8 0 0.100 0.242 1.000 42 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), FH(2), IDH2(1), MDH1(1), SUCLA2(1) 2156731 6 6 6 1 0 0 0 2 4 0 0.485 0.243 1.000 43 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(2), SULT1E1(2) 1463166 4 4 4 1 0 2 1 1 0 0 0.512 0.243 1.000 44 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD86(2), CTLA4(2), ICOS(1), PIK3CA(2), PIK3R1(2), PTPN11(1) 3077017 10 10 10 2 0 3 1 4 2 0 0.537 0.246 1.000 45 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), SNCAIP(2), UBE2L3(1) 1541971 5 5 5 1 0 1 0 3 1 0 0.510 0.250 1.000 46 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), SHMT2(2), TYMS(1) 4324859 11 11 11 0 0 2 3 5 1 0 0.0529 0.251 1.000 47 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(3), ITGB1(2), LYN(1) 3791760 10 10 10 1 1 1 0 5 3 0 0.428 0.255 1.000 48 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(2), SDHD(1) 1589838 4 4 4 1 0 2 2 0 0 0 0.461 0.275 1.000 49 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 3085025 8 8 8 1 0 1 2 2 3 0 0.418 0.276 1.000 50 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(2), HSD17B4(1), MECR(3) 2059509 6 6 6 0 1 1 0 4 0 0 0.207 0.277 1.000 51 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(1) 1767040 5 5 5 1 0 0 3 2 0 0 0.622 0.277 1.000 52 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2) 727593 2 2 2 0 0 0 1 0 1 0 0.747 0.279 1.000 53 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(2), JAK1(2), JAK2(1), JAK3(1), STAT1(1), STAT5A(1) 4510147 12 12 12 1 2 0 1 8 1 0 0.269 0.279 1.000 54 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 HMGB1(3), HMGB2(2), TOP2A(1), TOP2B(4) 2327433 10 9 10 2 1 2 1 3 3 0 0.657 0.284 1.000 55 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), EHHADH(1), HADHA(2) 2028716 6 6 6 1 0 0 0 5 1 0 0.647 0.287 1.000 56 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1), SUCLA2(1) 517635 2 2 2 1 0 0 1 1 0 0 0.869 0.294 1.000 57 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CUL1(2), FBXW7(2) 2006615 5 5 5 0 1 1 2 0 1 0 0.203 0.312 1.000 58 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(2), GAD2(1), GGT1(1) 1404186 6 6 6 2 1 1 2 1 1 0 0.646 0.312 1.000 59 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 3235278 8 8 8 1 0 1 2 2 3 0 0.421 0.320 1.000 60 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(6) 1993431 7 7 7 2 0 1 1 4 1 0 0.677 0.323 1.000 61 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(1), PLCB1(2), TUB(1) 1721561 6 5 6 0 0 1 0 5 0 0 0.250 0.331 1.000 62 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(1), ACOX3(3), ELOVL6(1), FADS1(1), FASN(5), HADHA(2), PECR(1) 3608891 17 12 17 3 1 4 0 10 2 0 0.264 0.341 1.000 63 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP6(2), ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), CMBL(1), CYP3A43(2), CYP3A7(1), PON2(2) 4383421 12 12 11 2 1 2 1 4 4 0 0.469 0.341 1.000 64 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 2575227 6 6 6 1 1 1 0 2 2 0 0.401 0.351 1.000 65 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(3), ACACB(1), FASN(5), MCAT(2), OLAH(1), OXSM(2) 3947691 14 14 14 3 1 6 1 4 2 0 0.231 0.363 1.000 66 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 397196 1 1 1 1 0 0 1 0 0 0 0.899 0.367 1.000 67 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 2708738 6 6 6 1 1 1 0 2 2 0 0.404 0.390 1.000 68 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(3), CYP2A7(1) 1928876 6 5 6 1 0 2 0 4 0 0 0.425 0.392 1.000 69 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), GBA(1), GBA3(1), MPO(2), PRDX6(2) 2039185 7 7 7 2 1 0 2 3 1 0 0.625 0.395 1.000 70 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), MTHFD2(1), POLB(1), POLD1(1), POLG(2), PRPS2(1) 3078420 8 8 8 0 0 1 1 4 2 0 0.211 0.408 1.000 71 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(1), HSD17B4(1), HSD17B7(1) 1950857 5 4 5 1 1 1 0 2 1 0 0.587 0.408 1.000 72 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), NOTCH1(5) 2284097 7 7 7 2 1 3 0 2 1 0 0.426 0.408 1.000 73 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(4), CPS1(1), EPRS(2), GAD1(2), GAD2(1), GCLC(3), GFPT1(1), GLS(2), GLUL(2), GMPS(1), GPT(2), PPAT(1) 8035287 23 22 23 3 1 4 5 9 4 0 0.117 0.412 1.000 74 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(1), SQLE(1) 1040548 2 2 2 0 1 1 0 0 0 0 0.440 0.418 1.000 75 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(2), PLCG1(1), VAV1(1) 3099761 9 9 9 2 0 2 0 6 1 0 0.652 0.423 1.000 76 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), ADC(1), AGMAT(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AMD1(2), AOC2(1), AOC3(1), ARG2(1), ASS1(1), CPS1(1), MAOA(1), MAOB(2), NAGS(1), SAT2(1) 7182804 23 20 23 3 3 2 5 7 6 0 0.124 0.430 1.000 77 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(2) 1669583 4 4 4 1 0 1 1 2 0 0 0.686 0.432 1.000 78 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAS(1), GNB1(1), LIMK1(2), NOX1(1), PIK3C2G(2), PLCB1(2), PTK2(1), RAF1(2), ROCK2(1) 6139095 15 15 15 2 2 4 3 4 2 0 0.161 0.441 1.000 79 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(1), F2R(1), PLAU(1), PLG(2), SERPINB2(1) 3233348 9 9 9 2 2 1 1 4 1 0 0.558 0.449 1.000 80 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), IL6ST(3), JAK1(2), JAK2(1), JAK3(1), PTPN11(1), RAF1(2), SOS1(3) 5801557 15 14 15 2 2 2 1 6 4 0 0.201 0.451 1.000 81 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(1) 782147 3 2 3 1 0 1 0 2 0 0 0.653 0.453 1.000 82 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), CYP2A13(2), CYP2A6(3), CYP2A7(1), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP3A7(1), CYP4F8(1), CYP51A1(2) 7098325 17 15 17 1 2 4 1 7 3 0 0.0523 0.454 1.000 83 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLG(2), POLQ(5) 4056855 9 9 9 1 0 1 2 3 3 0 0.446 0.455 1.000 84 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), HS3ST3A1(1), XYLT1(2) 1643817 4 4 4 0 1 0 0 2 1 0 0.364 0.461 1.000 85 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), HS3ST3A1(1), XYLT1(2) 1643817 4 4 4 0 1 0 0 2 1 0 0.364 0.461 1.000 86 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PLCB1(2), PLCB2(2) 2687145 6 6 6 1 1 0 0 3 2 0 0.653 0.465 1.000 87 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 539801 1 1 1 0 0 0 0 1 0 0 0.836 0.469 1.000 88 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), UGDH(1) 946985 2 2 2 0 0 0 1 1 0 0 0.585 0.469 1.000 89 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS2(1), ILVBL(1), LARS(4), VARS(2), VARS2(3) 4501022 11 11 11 2 1 1 4 2 3 0 0.359 0.472 1.000 90 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 TP53(4) 1711784 4 4 4 0 0 0 0 3 1 0 0.373 0.486 1.000 91 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACSL1(2), EHHADH(1), HADHA(2), PECR(1), SCP2(1) 4070942 10 10 10 2 0 3 0 5 1 1 0.426 0.486 1.000 92 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 11 AHCY(4), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(2), MARS(1), MARS2(1), MAT1A(1), MAT2B(1) 4028568 17 16 17 4 1 3 1 6 6 0 0.547 0.495 1.000 93 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), IGF1R(1), POLR2A(3), TEP1(4), TERF1(2), TERT(3), TNKS(2), TP53(4), XRCC5(1) 6810115 21 21 21 4 3 4 0 12 2 0 0.210 0.502 1.000 94 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), GBA3(1), MPO(2), PRDX2(1), PRDX6(2) 2351166 7 7 7 2 1 0 3 2 1 0 0.597 0.514 1.000 95 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SEC22B(1), SNAP29(1), STX11(1), STX17(1), STX18(1), STX2(1), STX4(1), STX5(1), TSNARE1(1), USE1(1) 4069819 10 10 10 2 2 1 1 5 1 0 0.394 0.518 1.000 96 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ENPP1(4), ENPP3(1), FLAD1(1) 2345468 6 5 6 0 0 1 0 4 1 0 0.316 0.521 1.000 97 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), NFKB1(1), NOX1(1), RELA(1), TNF(1) 2418041 5 5 5 1 0 1 1 1 2 0 0.685 0.535 1.000 98 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(1), GPT(2), MDH1(1), ME2(1), RPE(1), RPIA(1), TKT(1), TPI1(1) 4371448 9 9 9 1 1 1 2 2 3 0 0.327 0.539 1.000 99 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(1), TPI1(1) 940999 2 2 2 1 0 0 1 0 1 0 0.916 0.539 1.000 100 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(1), CYP17A1(2) 1672778 5 3 5 0 1 0 0 4 0 0 0.311 0.548 1.000 101 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(1), GPT(2), MDH1(1), PGK2(1), RPE(1), RPIA(1), TKT(1), TKTL2(1), TPI1(1) 4882125 10 10 10 1 1 1 2 3 3 0 0.281 0.561 1.000 102 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), GREB1(4), MTA1(1), MTA3(1), PDZK1(1) 2685703 9 7 9 2 1 1 1 3 3 0 0.677 0.567 1.000 103 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(1), BMPR1B(1) 1510342 3 3 3 0 0 1 0 1 1 0 0.334 0.574 1.000 104 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(1) 2492309 7 7 7 2 0 3 0 3 1 0 0.533 0.576 1.000 105 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BAAT(1), CEL(2), SOAT2(1), SRD5A1(1) 5617925 16 15 16 3 2 1 3 7 3 0 0.414 0.580 1.000 106 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(4) 2415433 4 4 4 0 1 0 1 0 2 0 0.476 0.580 1.000 107 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(1), MPO(2), PRDX2(1), PRDX6(2), SHMT2(2) 2875724 8 8 8 2 1 0 3 3 1 0 0.542 0.582 1.000 108 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 PAPSS2(2), SULT1E1(2) 2226255 4 4 4 1 0 2 1 1 0 0 0.464 0.582 1.000 109 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), EHHADH(1), HADHA(2) 1891303 4 4 4 1 0 0 0 4 0 0 0.720 0.582 1.000 110 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(2), HDC(1) 1468369 3 3 3 1 0 1 0 1 1 0 0.742 0.583 1.000 111 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2) 3218462 8 8 8 2 1 1 3 3 0 0 0.482 0.587 1.000 112 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2) 1134812 2 2 2 1 0 1 0 1 0 0 0.893 0.588 1.000 113 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), CYP17A1(2), CYP21A2(1) 2281329 5 4 5 1 1 0 0 2 2 0 0.631 0.589 1.000 114 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), CYP17A1(2), CYP21A2(1) 2281329 5 4 5 1 1 0 0 2 2 0 0.631 0.589 1.000 115 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(2), CAMP(1), CREB3(1), RAF1(2), SNX13(1), SRC(1) 2744561 10 9 10 3 1 0 3 4 2 0 0.726 0.597 1.000 116 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), UGDH(1) 1198581 2 2 2 0 0 0 1 1 0 0 0.576 0.604 1.000 117 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB11(1), ABCB4(3), ABCC1(2), GSTP1(2) 3468826 8 8 8 2 1 3 2 1 1 0 0.372 0.605 1.000 118 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 782278 1 1 1 0 0 1 0 0 0 0 0.628 0.607 1.000 119 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), SHMT2(2), TYMS(1) 4600541 11 11 11 2 0 2 3 5 1 0 0.427 0.611 1.000 120 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 TGFBR1(1), TGFBR2(1), TOB1(3) 2568545 5 5 5 0 0 1 1 3 0 0 0.260 0.617 1.000 121 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(1), EIF4A2(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(4), IRS1(1), PABPC1(1), PIK3CA(2), PIK3R1(2), PTEN(5) 6795039 21 18 21 3 1 4 3 5 8 0 0.236 0.626 1.000 122 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(1), GLS(2) 1874708 3 3 3 1 0 0 1 1 1 0 0.827 0.634 1.000 123 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNGR1(1), JAK1(2), JAK2(1), STAT1(1) 2758507 7 7 7 2 1 0 0 5 1 0 0.762 0.634 1.000 124 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(2), PLCB1(2), RELA(1) 1995037 6 6 6 2 1 0 0 4 1 0 0.816 0.636 1.000 125 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS3(1), SRC(1) 3707857 8 7 8 1 1 1 1 4 1 0 0.400 0.645 1.000 126 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CTLA4(2), DAG1(3), FBXW7(2), ITPKA(1), ITPKB(1), LAT(1), LCP2(2), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RAF1(2), RASGRP1(1), RASGRP3(1), SOS1(3), SOS2(1), VAV1(1), ZAP70(1) 13646744 38 32 38 4 3 8 5 11 11 0 0.0140 0.649 1.000 127 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), SCAP(2), SREBF1(2), SREBF2(2) 2978981 7 7 7 2 0 0 2 4 1 0 0.727 0.653 1.000 128 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), PAH(2), YARS2(1) 2104714 4 4 4 0 0 0 1 2 1 0 0.497 0.655 1.000 129 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), AOC3(1), CES1(1), ESD(1) 1453760 4 4 4 2 0 1 2 1 0 0 0.821 0.656 1.000 130 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(3), SELL(1), TNF(1), TNFRSF1B(1), TNFSF8(1) 3273177 7 6 7 1 0 2 1 2 2 0 0.383 0.658 1.000 131 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), JAK1(2), JAK3(1), RAF1(2), SOS1(3), STAT5A(1) 5705006 11 11 11 1 2 1 1 2 5 0 0.208 0.659 1.000 132 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 723581 1 1 1 1 0 0 0 1 0 0 0.979 0.669 1.000 133 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(2) 1214742 2 2 2 0 0 0 0 1 1 0 0.836 0.670 1.000 134 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DOT1L(6), EHHADH(1), EHMT1(1), EHMT2(3), HADHA(2), PLOD2(1), SHMT2(2) 8934729 26 22 26 3 3 5 4 12 2 0 0.0356 0.670 1.000 135 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ARG2(1), CKB(1), CPS1(1), NAGS(1), OAT(1) 4287252 8 8 8 1 0 0 1 4 3 0 0.610 0.673 1.000 136 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 SOS1(3), SRC(1) 2126898 4 4 4 1 0 1 0 1 2 0 0.577 0.679 1.000 137 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(1), ACO1(1), ACSS1(1), FH(2), IDH2(1), MDH1(1), SUCLA2(1) 3215949 8 7 8 3 0 0 0 3 5 0 0.836 0.683 1.000 138 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), DLD(2), FH(2), IDH2(1), IDH3B(2), MDH1(1), PC(5), PCK1(1), SDHA(2), SUCLA2(1) 4987243 18 16 18 6 0 3 2 5 7 1 0.688 0.686 1.000 139 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(2), STAT1(1) 2627593 4 4 4 1 1 0 0 2 1 0 0.550 0.686 1.000 140 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), GNB1(1), ITGA1(3), ITGB1(2), PLA2G4A(1), PLCB1(2), PTK2(1), RAF1(2), SRC(1), TBXAS1(1) 5880272 16 16 16 3 1 0 3 9 3 0 0.505 0.703 1.000 141 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNE1(1), CUL1(2) 2074980 3 3 3 0 1 0 2 0 0 0 0.323 0.704 1.000 142 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(2) 2070731 3 3 3 0 1 0 2 0 0 0 0.329 0.705 1.000 143 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHPF(1), CHST3(1), CHST7(1), UST(1), XYLT1(2) 3434015 6 6 6 1 1 1 0 3 1 0 0.475 0.708 1.000 144 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(1), NFKB1(1), RELA(1) 2677606 4 4 4 1 1 0 0 1 2 0 0.667 0.715 1.000 145 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), INS(1), IRS1(1), PIK3CA(2), PIK3R1(2), PTPN11(1), RAF1(2), RASA1(2), SLC2A4(1), SOS1(3) 6160478 17 16 17 3 2 3 0 6 6 0 0.356 0.716 1.000 146 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), ERBB3(1), NRG1(2) 2484594 4 4 4 0 1 1 0 2 0 0 0.315 0.717 1.000 147 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), LDHB(1), SULT1C2(1), SULT1C4(2) 3036352 5 5 5 1 0 0 3 2 0 0 0.531 0.720 1.000 148 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B4GALT1(1), CHST2(1), CHST6(1), ST3GAL4(1) 2994315 5 5 5 1 2 1 0 2 0 0 0.390 0.721 1.000 149 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(1), ALPP(1), ALPPL2(1) 1608829 4 4 4 2 1 2 1 0 0 0 0.667 0.722 1.000 150 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), GALNT10(2), GALNT11(1), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(1), GALNT6(2), GALNT7(1), GALNTL5(1), GCNT3(2), GCNT4(1), OGT(1), WBSCR17(1) 7814738 19 17 18 3 1 2 6 3 7 0 0.186 0.727 1.000 151 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(3), LEPR(1), PRKAG2(2) 3484515 6 6 6 1 0 1 2 2 1 0 0.420 0.727 1.000 152 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(1), MPO(2), PRDX6(2), SHMT2(2) 2818501 7 7 7 2 1 0 2 3 1 0 0.628 0.728 1.000 153 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 LSS(2), NQO2(1), SQLE(1) 2712608 4 4 4 0 0 2 1 0 1 0 0.227 0.729 1.000 154 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ACY3(1), ADSL(2), ADSSL1(1), AGXT(1), AGXT2(1), ASNS(1), ASS1(1), CAD(4), CRAT(2), DARS(2), DDO(1), DLD(2), GAD1(2), GAD2(1), GPT(2), NARS2(1), PC(5) 9199431 32 27 32 5 2 4 4 11 10 1 0.190 0.729 1.000 155 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 GAD1(2), GAD2(1), HDC(1), MAOA(1), PAH(2), SLC18A3(1) 3521301 8 8 8 2 0 2 1 4 1 0 0.511 0.731 1.000 156 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 LDLR(1), LPL(1) 1283635 2 2 2 1 0 0 0 2 0 0 0.866 0.732 1.000 157 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA7(1), PSMB1(2), PSMB10(1) 2118461 5 5 5 2 1 0 0 3 1 0 0.780 0.736 1.000 158 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 MAP3K14(1), NFKB1(1), NFKBIA(2), RELA(1), TP53(4) 2422602 9 9 9 3 1 1 0 5 2 0 0.714 0.737 1.000 159 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HDC(1), HNMT(1), MAOA(1), MAOB(2), PRPS2(1) 5923857 16 15 16 3 3 3 3 6 1 0 0.235 0.742 1.000 160 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), EHHADH(1), HADHA(2), HSD17B4(1), NTAN1(1) 2873255 7 7 7 2 0 1 1 4 1 0 0.567 0.743 1.000 161 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLD(2), FH(2), IDH2(1), IDH3B(2), MDH1(1), OGDH(5), PC(5), PDHX(1), PDK4(1), SDHA(2), SDHD(1), SUCLA2(1) 6898030 24 21 24 5 0 4 3 7 9 1 0.356 0.749 1.000 162 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), JAK1(2), JAK2(1), STAT1(1) 1968166 5 5 5 2 1 0 0 4 0 0 0.870 0.749 1.000 163 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), BAD(1), CHRNB1(2), MUSK(1), PIK3CA(2), PIK3R1(2), PTK2(1), RAPSN(1), SRC(1), TERT(3) 3998241 15 15 15 4 0 2 2 9 2 0 0.582 0.751 1.000 164 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 DNMT1(2), PTGDR(1), PTGFR(2), PTGIR(1) 2721188 6 5 6 2 1 0 2 2 1 0 0.727 0.755 1.000 165 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), TNF(1), TNFRSF1B(1) 2049649 3 3 3 1 0 1 0 1 1 0 0.869 0.755 1.000 166 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), IGF1R(1), IRS1(1), PIK3CA(2), PIK3R1(2), PTPN11(1), RAF1(2), RASA1(2), SOS1(3) 5979883 16 15 16 3 2 3 0 5 6 0 0.399 0.756 1.000 167 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS1(1), PIAS3(1) 3345250 8 7 8 2 1 1 2 3 1 0 0.586 0.765 1.000 168 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 BST1(2), ENPP1(4), ENPP3(1), NADK(1), NNT(1), NT5C1B(1) 5209025 10 9 9 1 0 0 0 9 1 0 0.433 0.766 1.000 169 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), LDHB(1) 1641762 2 2 2 1 0 0 1 1 0 0 0.841 0.767 1.000 170 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), DPYD(1), DPYS(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1) 6539811 18 18 18 4 1 3 4 6 4 0 0.394 0.767 1.000 171 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT6(1) 1233787 2 2 2 0 0 0 0 2 0 0 0.669 0.772 1.000 172 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 PTPRC(2), ZAP70(1) 2179528 3 3 3 1 0 0 0 1 2 0 0.803 0.773 1.000 173 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD2(6) 1094435 8 8 6 5 0 0 3 4 1 0 0.939 0.779 1.000 174 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 750598 1 1 1 0 0 0 0 1 0 0 0.833 0.780 1.000 175 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(1), CCNE1(1), TP53(4) 4374716 7 7 7 1 0 0 1 3 3 0 0.379 0.783 1.000 176 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(1), ST3GAL4(1) 1899893 3 3 3 0 1 0 0 2 0 0 0.489 0.783 1.000 177 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 1628655 2 2 2 0 1 0 0 1 0 0 0.585 0.788 1.000 178 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(1), DPAGT1(2), MGAT2(1), MGAT3(1), MGAT5(1), RPN1(1), ST6GAL1(1) 4841177 9 7 9 0 1 3 0 1 4 0 0.0401 0.790 1.000 179 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1) 814873 1 1 1 1 0 0 0 1 0 0 0.935 0.792 1.000 180 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(2), INPPL1(2), ITPKA(1), ITPKB(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(2), PIK3CB(1), PIK3CG(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCG1(1), PLCG2(2) 10908611 29 27 29 4 2 6 2 13 6 0 0.123 0.792 1.000 181 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGT(3), AGTR2(1), COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3) 6170600 13 12 13 2 0 2 1 9 1 0 0.250 0.793 1.000 182 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), MDH1(1), PC(5), SLC25A1(1) 2245654 8 7 8 4 0 0 1 4 3 0 0.945 0.797 1.000 183 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1) 779369 1 1 1 1 0 0 0 1 0 0 0.932 0.799 1.000 184 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15B(1), ALOX5(2), GGT1(1), PLA2G6(1), PTGS2(1), TBXAS1(1) 3719306 8 8 8 2 0 1 3 3 1 0 0.520 0.801 1.000 185 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CBL(1), CSF1R(1), EGF(1), PDGFRA(1), SH3KBP1(2), SRC(1) 4007280 7 6 7 1 1 1 0 4 1 0 0.525 0.801 1.000 186 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(1) 867185 1 1 1 0 0 0 0 1 0 0 0.840 0.803 1.000 187 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT2(1) 1490278 2 2 2 0 0 0 0 2 0 0 0.693 0.803 1.000 188 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(1), ALOX12B(1), ALOX15B(1), ALOX5(2), CBR1(1), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F2(1), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PTGS2(1), TBXAS1(1) 9527579 22 21 22 3 2 3 3 11 3 0 0.144 0.803 1.000 189 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(2), JAK2(1), PLCG1(1), RAF1(2), SOS1(3), STAT5A(1) 5239741 12 11 12 2 1 1 1 4 5 0 0.413 0.804 1.000 190 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR2(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 3663909 7 7 7 2 1 1 0 3 2 0 0.661 0.805 1.000 191 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 PTGS2(1) 1278741 1 1 1 0 0 0 1 0 0 0 0.751 0.806 1.000 192 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL4(1), ST6GALNAC2(1) 1365205 2 2 2 0 1 0 0 1 0 0 0.547 0.807 1.000 193 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(2), STAT1(1) 3027593 4 4 4 1 1 0 0 2 1 0 0.534 0.808 1.000 194 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(1), PGM1(1) 2498953 4 4 4 1 1 0 0 3 0 0 0.645 0.811 1.000 195 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 PSAT1(1) 1167383 1 1 1 1 0 0 0 0 1 0 1.000 0.815 1.000 196 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(1), PTPRB(2), RAF1(2), RASA1(2), SOS1(3), SPRY2(1), SRC(1) 6040768 13 13 13 2 0 2 1 6 4 0 0.337 0.818 1.000 197 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(1), JAK3(1) 2875770 4 4 4 1 1 0 1 2 0 0 0.682 0.819 1.000 198 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), THBS1(4) 1767161 5 5 5 4 0 0 3 0 2 0 0.982 0.821 1.000 199 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(2), ANXA6(1), CYP11A1(1), PLA2G4A(1), PTGDR(1), PTGFR(2), PTGIR(1), PTGS2(1), TBXAS1(1) 4981768 12 10 12 3 2 0 4 4 2 0 0.501 0.822 1.000 200 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 911442 1 1 1 0 0 0 0 0 1 0 1.000 0.824 1.000 201 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 AKT1(1), ATM(1), CPB2(1), HIC1(1), HIF1A(1), TP53(4) 5044450 9 9 9 2 0 0 0 6 2 1 0.603 0.825 1.000 202 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(1), IRS1(1), JAK1(2), JAK3(1), STAT6(1) 3591542 7 7 7 2 2 0 1 3 1 0 0.596 0.827 1.000 203 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F2R(1), F5(3), PROS1(1), TFPI(1) 3962866 8 8 8 2 1 0 1 3 3 0 0.768 0.827 1.000 204 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), LSS(2), SQLE(1) 3222762 5 4 5 0 0 2 0 1 2 0 0.275 0.834 1.000 205 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(3), ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), LDHB(1), PCCA(1), SUCLA2(1) 8001737 19 19 19 4 1 4 5 7 1 1 0.222 0.834 1.000 206 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(1), ITGB1(2), PIK3CA(2), PIK3R1(2), PTEN(5), PTK2(1), SOS1(3) 4688560 17 16 17 5 0 3 3 4 7 0 0.629 0.835 1.000 207 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), GATA1(2), UROD(1) 1942686 5 5 5 4 2 1 0 0 2 0 0.947 0.838 1.000 208 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 NFKB1(1), NFKBIA(2), PLCB1(2), RAF1(2), RELA(1), TNF(1) 3744385 9 8 9 2 1 0 0 5 3 0 0.766 0.842 1.000 209 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(1), ITGB1(2), KLRC1(1), KLRC2(1), KLRC3(1), LAT(1), PAK1(1), PIK3CA(2), PIK3R1(2), VAV1(1) 4526385 14 11 14 3 0 3 1 4 5 1 0.713 0.845 1.000 210 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(3), AGTR2(1), EGF(1), NFKB1(1), PLCG1(1), RELA(1) 4957872 10 8 10 1 1 1 0 7 1 0 0.325 0.848 1.000 211 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2I(1), UBE2L3(1), UBE2N(2), UBE3A(1) 2542079 5 5 5 2 0 0 1 4 0 0 0.808 0.856 1.000 212 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 ENPP1(4), ENPP3(1), NNT(1) 3527759 6 5 6 1 0 0 0 5 1 0 0.669 0.863 1.000 213 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(1), HK1(1), RENBP(2) 4117909 7 7 7 1 0 0 0 6 1 0 0.585 0.865 1.000 214 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 PAH(2) 1999130 2 2 2 0 0 0 1 1 0 0 0.610 0.866 1.000 215 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B4GALT1(1), FUT2(1), FUT4(1), FUT6(1), FUT7(1) 3897416 6 6 6 1 1 0 0 4 1 0 0.558 0.867 1.000 216 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CTH(1) 1190025 1 1 1 1 0 0 0 1 0 0 0.945 0.868 1.000 217 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3), P4HB(1), SLC23A1(2), SLC23A2(1), SLC2A1(1) 6165637 14 13 14 3 0 2 2 8 2 0 0.379 0.869 1.000 218 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1) 1605146 1 1 1 0 0 1 0 0 0 0 0.710 0.869 1.000 219 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 IL9(1) 1487765 1 1 1 0 0 0 1 0 0 0 0.739 0.871 1.000 220 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 AHCY(4), AMD1(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(2), MARS(1), MARS2(1), MAT1A(1), MAT2B(1) 4841464 19 18 19 5 2 3 2 6 6 0 0.594 0.873 1.000 221 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 EP300(5), HIF1A(1), NOS3(1), P4HB(1), VHL(2) 4123274 10 10 10 3 1 0 0 4 4 1 0.895 0.878 1.000 222 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(2), TNF(1) 1395601 4 4 4 3 0 0 1 2 1 0 0.964 0.879 1.000 223 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2) 3275763 12 12 12 4 2 1 1 5 3 0 0.729 0.886 1.000 224 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(1), PGM1(1) 2851686 4 4 4 1 1 0 0 3 0 0 0.634 0.887 1.000 225 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(4), HMGB2(2) 2573972 8 8 8 3 1 2 2 0 3 0 0.538 0.889 1.000 226 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1) 1504884 1 1 1 0 0 0 1 0 0 0 0.709 0.890 1.000 227 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1) 3415511 7 6 7 3 0 0 1 2 4 0 0.785 0.890 1.000 228 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1) 3644944 5 5 5 1 0 1 0 4 0 0 0.592 0.890 1.000 229 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1) 3644944 5 5 5 1 0 1 0 4 0 0 0.592 0.890 1.000 230 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1) 3644944 5 5 5 1 0 1 0 4 0 0 0.592 0.890 1.000 231 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 NDUFB11(1) 990437 1 1 1 1 0 0 0 1 0 0 0.972 0.891 1.000 232 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), F2(1), F2RL2(1), MAP2K5(2), MAPK7(3), MYEF2(1), PTK2(1), RAF1(2), RASAL1(1), SRC(1), VAV1(1) 6693005 15 15 14 3 2 2 2 8 1 0 0.306 0.899 1.000 233 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 DCXR(1), RPE(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1) 4236743 7 7 7 2 0 1 4 1 1 0 0.549 0.899 1.000 234 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), FDXR(2) 3878501 7 7 7 2 0 1 0 6 0 0 0.654 0.902 1.000 235 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1) 5036380 7 7 7 1 1 0 0 3 3 0 0.650 0.902 1.000 236 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT2(1), ST3GAL4(1) 1739627 2 2 2 0 0 0 0 2 0 0 0.692 0.903 1.000 237 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), DPYD(1), DPYS(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2) 7026885 21 21 21 5 1 5 3 7 4 1 0.376 0.906 1.000 238 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT2(1), GALNT4(1), GALNT6(2), GALNT7(1), ST3GAL4(1), WBSCR17(1) 3511712 9 9 9 3 0 1 1 3 4 0 0.731 0.907 1.000 239 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK2A(1), CAMKK1(2) 2845316 5 5 5 2 1 0 2 2 0 0 0.693 0.907 1.000 240 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(1), H6PD(2), PFKP(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(1), TAL1(1), TKT(1) 4926039 11 11 11 3 3 1 1 3 3 0 0.640 0.909 1.000 241 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1) 1313330 1 1 1 1 0 0 0 1 0 0 0.930 0.910 1.000 242 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(3), LCT(3), PGM1(1), PYGL(1), PYGM(1), TPI1(1) 3269977 11 11 11 4 3 0 2 5 1 0 0.713 0.910 1.000 243 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(3), AGT(3), AGTR2(1), ANPEP(2), ENPEP(2), LNPEP(1) 5110768 12 10 12 3 1 2 2 6 1 0 0.502 0.910 1.000 244 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(1), ACO1(1), CLYBL(1), DLD(2), FH(2), IDH2(1), IDH3B(2), MDH1(1), OGDH(5), PC(5), PCK1(1), PCK2(1), SDHA(2), SDHD(1), SUCLA2(1) 7219475 27 22 27 9 1 4 3 10 8 1 0.716 0.915 1.000 245 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1) 3638552 6 5 6 3 0 0 1 1 4 0 0.847 0.919 1.000 246 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(1), CASP1(1), GAPDH(2), INS(1), MAGI1(1), MAGI2(2), RERE(7), WWP1(6), WWP2(1) 5791683 23 22 23 6 4 0 2 11 6 0 0.755 0.919 1.000 247 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), UROD(1) 1852416 3 3 3 3 1 1 0 0 1 0 0.943 0.920 1.000 248 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNB1(1), CCNE1(1), CDKN2A(2) 3888930 4 4 4 1 0 1 1 1 1 0 0.521 0.921 1.000 249 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C6(2), C7(1), ICAM1(1), ITGA4(1), ITGAL(2), ITGB1(2), ITGB2(1), TNF(1), VCAM1(2) 5973810 14 12 14 3 1 1 1 9 2 0 0.622 0.923 1.000 250 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), IFNGR1(1), IL12RB1(1), IL4R(1) 3065997 5 5 5 2 0 0 0 2 3 0 0.912 0.926 1.000 251 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(1), CHEK1(1), MYT1(2), TP53(4) 4252861 8 8 8 2 0 0 1 5 2 0 0.566 0.929 1.000 252 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 TIMP2(1) 1833353 1 1 1 1 0 0 0 0 1 0 1.000 0.930 1.000 253 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(5), SRC(1) 3621849 10 10 10 6 0 2 1 3 4 0 0.951 0.932 1.000 254 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(2), CLTA(1), CLTB(1), GBF1(6), GPLD1(1), KDELR3(2) 3921570 14 14 14 7 0 1 3 6 4 0 0.953 0.934 1.000 255 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), PNPLA3(1), YOD1(1) 7465336 12 12 12 2 1 2 3 4 2 0 0.315 0.936 1.000 256 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH4A1(1), AMD1(2), AOC2(1), AOC3(1), ARG2(1), CKB(1), CPS1(1), MAOA(1), MAOB(2), NOS1(1), NOS3(1), OAT(1), P4HA1(1), P4HB(1), RARS(1) 10762799 24 23 24 4 4 2 6 8 4 0 0.164 0.937 1.000 257 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(1), CRKL(1), DOCK1(2), GAB1(1), ITGA1(3), ITGB1(2), MAP2K2(1), MAP4K1(2), PAK1(1), PIK3CA(2), PIK3R1(2), PTEN(5), PTK2(1), PTPN11(1), PXN(1), RAF1(2), RASA1(2), SOS1(3), SRC(1) 10114871 34 30 34 7 0 4 5 12 13 0 0.458 0.938 1.000 258 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), ITGAX(4), TLR4(1), TLR7(1) 4494682 8 7 8 2 2 0 2 3 1 0 0.411 0.938 1.000 259 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(1), AOC3(1), CES1(1), LIPA(1), PNPLA3(1), PRDX6(2) 6113002 7 7 7 1 0 2 2 1 2 0 0.463 0.939 1.000 260 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CTH(1), GGT1(1), MARS(1), MARS2(1), MAT1A(1), MAT2B(1), PAPSS2(2), SCLY(1) 3006316 13 12 13 5 0 5 2 3 3 0 0.693 0.942 1.000 261 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(2), ABCC2(3), ABCG2(2), BCHE(1), CES1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1) 5493033 13 13 13 4 0 2 4 4 3 0 0.621 0.942 1.000 262 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(1), RPL10A(1), RPL11(1), RPL13(1), RPL14(1), RPL18(1), RPL19(1), RPL24(1), RPL26(1), RPL3(2), RPL3L(1), RPL6(1), RPS2(1), RPS24(1), RPS7(1), RPS8(1), RPSA(1) 5437011 20 20 20 7 2 2 2 7 7 0 0.845 0.943 1.000 263 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(2), LCT(3), MANBA(1) 4046423 6 6 6 2 1 0 1 3 1 0 0.785 0.944 1.000 264 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(5), LPL(1), NCOA1(1), NCOA2(2) 4448644 13 13 13 9 1 3 1 3 5 0 0.989 0.945 1.000 265 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 JUNB(1), MAF(1), MAP2K3(1), NFATC2(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 2951143 9 8 9 5 1 0 1 4 3 0 0.944 0.946 1.000 266 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 2436182 4 4 4 4 0 0 0 2 2 0 0.992 0.947 1.000 267 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), CASP1(1), CASP10(1), CASP9(1) 3092050 6 6 6 3 0 1 1 1 3 0 0.950 0.950 1.000 268 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(1), GNB1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 2359999 7 7 7 4 1 1 0 3 2 0 0.928 0.950 1.000 269 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 IL9(1) 2025594 1 1 1 1 0 0 1 0 0 0 0.956 0.953 1.000 270 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 CFTR(3), GNAS(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1) 3190415 8 8 8 5 1 0 2 2 3 0 0.949 0.953 1.000 271 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAD8(2), ACAD9(1), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BAAT(1), CEL(2), LIPA(1), RDH11(1), RDH13(1), SOAT2(1), SRD5A1(1) 7702614 22 21 22 5 2 2 3 11 4 0 0.490 0.955 1.000 272 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), JAK2(1), RAF1(2), SOS1(3), STAT5A(1) 4294331 8 7 8 2 0 1 0 3 4 0 0.685 0.956 1.000 273 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), SOS1(3) 4616487 12 12 12 4 1 3 0 3 5 0 0.742 0.959 1.000 274 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(1), TFRC(1) 3097339 3 3 3 0 0 0 0 3 0 0 0.615 0.959 1.000 275 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C6(2), C7(1) 3038601 4 3 4 1 0 0 0 4 0 0 0.826 0.959 1.000 276 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CHEK1(1) 1727314 1 1 1 0 0 0 0 1 0 0 0.847 0.960 1.000 277 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(1) 1943278 3 3 3 2 1 0 1 0 1 0 0.763 0.961 1.000 278 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ATF3(1), EIF4EBP1(1), IL1R1(1), WDR1(1) 2625205 4 4 4 2 0 1 1 2 0 0 0.851 0.961 1.000 279 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP10(1), CASP9(1), SCAP(2), SREBF1(2), SREBF2(2) 4498040 10 10 10 3 0 1 2 4 3 0 0.722 0.962 1.000 280 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(2), JAK2(1) 2532952 4 4 4 2 1 0 0 2 1 0 0.803 0.962 1.000 281 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(2), JAK2(1) 2532952 4 4 4 2 1 0 0 2 1 0 0.803 0.962 1.000 282 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CTH(1), GGT1(1), MARS(1), MARS2(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS2(2), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), SCLY(1), SEPHS2(2) 6054270 21 18 21 7 0 5 4 5 7 0 0.593 0.963 1.000 283 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(2), LCT(3), MAN2B1(1), MANBA(1) 4987788 7 7 7 2 2 0 1 3 1 0 0.679 0.964 1.000 284 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACMSD(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), CYP2A13(2), CYP2A6(3), CYP2A7(1), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP3A7(1), CYP4F8(1), CYP51A1(2), EHHADH(1), HAAO(1), HADHA(2), KYNU(1), MAOA(1), MAOB(2) 13314477 31 25 31 4 4 4 3 15 5 0 0.0765 0.965 1.000 285 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), PTPRA(1), SRC(1) 2240029 3 3 3 2 0 1 0 2 0 0 0.903 0.965 1.000 286 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), BAD(1), IGF1R(1), IRS1(1), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(3) 4558520 13 12 13 4 1 3 1 4 4 0 0.621 0.967 1.000 287 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA7(1), PSMB1(2), PSMD1(1), PSMD11(1), PSMD6(1) 3869959 7 7 7 5 2 0 0 2 3 0 0.974 0.968 1.000 288 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CMAS(1), GFPT1(1), HK1(1), MTMR2(2), MTMR6(1), NAGK(1), NANS(1), NPL(1), PHPT1(1), RENBP(2) 6965455 13 13 13 3 0 2 3 6 2 0 0.403 0.968 1.000 289 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(1) 1755551 1 1 1 1 0 0 0 1 0 0 0.942 0.968 1.000 290 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), GPT(2), LDHB(1) 2170579 5 5 5 3 0 0 3 1 1 0 0.917 0.969 1.000 291 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPOR(2), HIF1A(1), JAK2(1), NFKB1(1), NFKBIA(2), RELA(1) 3101695 8 7 8 4 1 0 1 4 1 1 0.923 0.969 1.000 292 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NFAT5(1), PDE6B(2), PDE6C(1), SLC6A13(4) 8731146 20 18 20 4 1 3 4 8 4 0 0.297 0.970 1.000 293 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 PON2(2), RDH11(1), RDH13(1) 2172765 4 4 4 3 0 0 0 3 1 0 0.969 0.971 1.000 294 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2) 5663978 14 14 14 4 3 1 0 7 3 0 0.668 0.971 1.000 295 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), NFKB1(1), RELA(1), TRAF5(2) 3537640 5 5 5 3 0 1 0 1 3 0 0.980 0.972 1.000 296 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), CASP9(1), DAXX(1), FASLG(2), TNF(1) 2725855 7 5 7 3 0 3 1 0 3 0 0.877 0.972 1.000 297 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 MAP2K2(1), RAF1(2) 2008334 3 3 3 2 0 0 0 2 1 0 0.963 0.972 1.000 298 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(1), C3(1), C6(2), C7(1), MASP1(1), MBL2(1) 5189042 7 6 7 1 0 0 1 6 0 0 0.572 0.973 1.000 299 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CREBBP(4), EP300(5), MAP3K7(1), SKIL(1), TGFBR1(1), TGFBR2(1) 6195815 14 13 14 4 0 3 1 5 4 1 0.679 0.973 1.000 300 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR161(1), GPR18(2), GPR39(1), GPR65(1) 2369541 5 5 5 3 1 2 0 2 0 0 0.863 0.973 1.000 301 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), ST3GAL4(1) 2441241 2 2 2 0 0 0 0 2 0 0 0.693 0.973 1.000 302 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), CETP(1), DGAT1(2), LCAT(2), LDLR(1), LPL(1), LRP1(1), SCARB1(1) 6623174 11 9 11 2 1 1 1 8 0 0 0.401 0.975 1.000 303 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 SLC18A3(1) 1697779 1 1 1 1 0 0 0 1 0 0 0.927 0.976 1.000 304 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 KEAP1(1) 1895586 1 1 1 2 0 0 0 0 1 0 0.989 0.977 1.000 305 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACADL(3), ACADSB(1), ACOX1(1), ACOX3(3), ACSL1(2), ACSL6(1), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CYP4A11(1), CYP4A22(1), EHHADH(1), HADHA(2), HSD17B4(1) 11855739 28 26 28 6 2 7 3 13 2 1 0.232 0.977 1.000 306 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), NTRK1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), SOS1(3) 3764807 11 10 11 5 1 3 0 4 3 0 0.805 0.979 1.000 307 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL16(1), IL9(1), TNF(1) 2395022 3 3 3 2 0 1 1 0 1 0 0.933 0.979 1.000 308 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), JAK2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1), THPO(1) 7235462 18 16 18 4 1 3 0 7 7 0 0.588 0.979 1.000 309 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(1), GNAS(1), GNB1(1), NFKB1(1), NOS3(1), NR3C1(2), PIK3CA(2), PIK3R1(2), RELA(1) 4389146 12 12 12 4 2 2 1 5 2 0 0.763 0.980 1.000 310 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1) 1816887 1 1 1 0 0 0 0 1 0 0 0.839 0.980 1.000 311 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), GNB1(1), PLCB1(2) 4988995 5 5 5 0 0 0 1 3 1 0 0.423 0.980 1.000 312 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DOT1L(6), EHHADH(1), EHMT1(1), EHMT2(3), HADHA(2), HSD17B4(1), NSD1(5), OGDH(5), PIPOX(2), PLOD2(1), RDH11(1), RDH13(1), SETD1A(3), SETDB1(2), SHMT2(2), SUV39H2(1) 14054836 45 38 45 9 3 8 4 21 9 0 0.199 0.981 1.000 313 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(1), SP100(1), TNF(1), TNFRSF1B(1), TP53(4) 4611774 12 11 12 5 0 3 1 3 5 0 0.762 0.982 1.000 314 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(1), CHEK1(1), MYT1(2) 3329632 4 4 4 2 0 0 1 2 1 0 0.814 0.983 1.000 315 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC2(1), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(2) 3234331 8 8 8 6 1 3 0 2 2 0 0.987 0.983 1.000 316 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BAD(1), CBL(1), CRKL(1), IRS1(1), JAK1(2), JAK3(1), PIK3CA(2), PIK3R1(2), PPIA(1), RAF1(2), SOS1(3), STAT5A(1) 8781056 19 16 19 4 2 4 2 6 5 0 0.353 0.984 1.000 317 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FHL5(1), GNAS(1), XPO1(2) 2324404 4 4 4 3 2 0 1 0 1 0 0.944 0.984 1.000 318 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(1), GNB1(1), PRKACG(1), PRKAG2(2), PRKAR2A(1), PRKAR2B(1) 3740886 7 7 7 5 1 0 0 3 3 0 0.963 0.985 1.000 319 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(4), EP300(5), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1), TNFRSF1B(1) 5424636 16 15 16 6 1 3 1 5 6 0 0.860 0.985 1.000 320 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(2), PIK3CA(2), PIK3R1(2), POLR1A(1), POLR1B(2), TP53(4) 4908605 16 14 16 5 1 3 0 7 5 0 0.702 0.986 1.000 321 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 POLR2A(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 3123547 6 6 6 5 2 0 0 2 2 0 0.958 0.986 1.000 322 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2S3(1), EIF4EBP1(1), IGF1R(1), INPPL1(2), PIK3CA(2), PIK3R1(2), PTEN(5) 4786378 15 14 15 5 2 3 2 4 4 0 0.718 0.986 1.000 323 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(3), ACACB(1), ACSS1(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), HIBCH(1), LDHB(1), PCCA(1), SUCLA2(1) 9600110 18 18 18 4 1 3 6 6 2 0 0.264 0.986 1.000 324 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 PLCB1(2), PPP1CA(1), PPP3CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 3876831 7 7 7 9 0 0 0 4 3 0 0.999 0.987 1.000 325 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(1), ALOX5(2), CBR1(1), CYP4F2(1), CYP4F3(2), EPX(1), GGT1(1), MPO(2), PLA2G4A(1), PLA2G6(1), PRDX2(1), PRDX6(2), PTGS2(1), TBXAS1(1) 6812195 20 18 20 5 2 0 6 8 4 0 0.525 0.987 1.000 326 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCL(1) 6251760 13 13 13 4 1 2 3 6 1 0 0.561 0.988 1.000 327 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(1), C3(1), C6(2), C7(1) 4259584 5 4 5 1 0 0 0 5 0 0 0.755 0.988 1.000 328 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK2A(1), ESRRA(1), HDAC5(3), PPP3CA(1), SLC2A4(1) 4999970 9 9 9 3 2 0 1 5 1 0 0.669 0.989 1.000 329 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(1), ATR(3), CHEK1(1), TP53(4) 3831555 9 9 9 3 0 1 0 6 2 0 0.752 0.989 1.000 330 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(2), AKT3(1), BAD(1), GSK3A(1), IL4R(1), IRS1(1), IRS2(2), JAK1(2), JAK3(1), MAP4K1(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), RAF1(2), SOS1(3), SOS2(1), STAT6(1) 8878453 27 23 27 6 3 5 5 8 6 0 0.251 0.989 1.000 331 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), BAD(1), CASP9(1), NFKB1(1), NFKBIA(2), PIK3CA(2), PIK3R1(2), RELA(1) 3412483 11 11 11 6 1 3 1 4 2 0 0.935 0.990 1.000 332 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CREBBP(4), GNAS(1), GNB1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(1) 5585638 12 11 12 8 1 2 1 3 5 0 0.957 0.990 1.000 333 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CREBBP(4), GNAS(1), GNB1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(1) 5585638 12 11 12 8 1 2 1 3 5 0 0.957 0.990 1.000 334 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), PPP1CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2) 4286124 8 8 8 4 0 1 0 4 3 0 0.922 0.990 1.000 335 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(1), CRKL(1), JAK2(1), MAP3K1(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(3), STAT1(1), STAT5A(1) 6758907 17 14 17 8 0 4 0 6 7 0 0.963 0.991 1.000 336 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(3), ITGB1(2), PIK3CA(2), PIK3R1(2), PTK2(1), PXN(1), RAF1(2), SRC(1), TLN1(7) 9053608 27 23 27 7 0 3 3 11 10 0 0.785 0.991 1.000 337 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(1), C3(1), C6(2), C7(1), MASP1(1) 5051102 6 5 6 1 0 0 0 6 0 0 0.692 0.992 1.000 338 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNGR1(1), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1), TNFRSF1B(1), TP53(4), USH1C(1) 4439852 14 13 14 6 1 1 0 9 3 0 0.929 0.992 1.000 339 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(2), ATP4A(1), ATP5A1(1), ATP5B(1), ATP5F1(1), ATP5L(1), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), COX10(3), COX15(1), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB10(1), NDUFB11(1), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFS3(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), SDHA(2), SDHD(1), TCIRG1(2) 13619031 38 35 37 9 3 4 7 16 8 0 0.381 0.992 1.000 340 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CAPN2(2), EP300(5), NFATC2(3), PPP3CA(1) 5872708 14 14 14 5 2 0 0 7 5 0 0.940 0.992 1.000 341 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), ALDH3B1(1), ALDH3B2(1), CYP1B1(1), CYP2C8(1), CYP2F1(1), CYP3A43(2), CYP3A7(1), DHDH(3), EPHX1(1), GSTA1(1), GSTA2(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1) 13923237 34 31 34 7 4 2 5 17 6 0 0.350 0.992 1.000 342 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), NFKB1(1), NFKBIA(2), PAK1(1), PIK3CA(2), PIK3R1(2), RAF1(2), RELA(1) 4896134 13 12 13 4 1 2 1 5 4 0 0.805 0.993 1.000 343 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BCKDHA(1), EHHADH(1), HADHA(2), HMGCL(1), MCCC1(1), PCCA(1) 8729350 20 19 20 5 1 3 4 9 2 1 0.390 0.993 1.000 344 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), EP300(5), IKBKB(1), MAP2K3(1), MAP3K14(1), MAP3K7(1), NFKB1(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(1), TNF(1) 7201443 22 18 22 7 1 4 2 8 6 1 0.706 0.993 1.000 345 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA1(1), CA6(1), CA9(1), CPS1(1), CTH(1), GLS(2), GLUL(2) 4583996 10 10 10 4 0 1 2 4 3 0 0.874 0.993 1.000 346 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA7(1), PSMB1(2), RPN1(1), UBE3A(1) 3143161 6 6 6 4 1 1 0 3 1 0 0.909 0.993 1.000 347 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(1), LCT(3), SMPD1(3), SMPD2(1), SPTLC2(2) 5872279 17 16 17 5 3 1 0 8 5 0 0.727 0.994 1.000 348 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 LCT(3), ST6GALNAC5(2) 3974321 5 4 5 2 1 1 0 2 1 0 0.859 0.994 1.000 349 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(1), ALDH4A1(1), CAD(4), CPS1(1), EPRS(2), GAD1(2), GAD2(1), GCLC(3), GFPT1(1), GLS(2), GLUD2(6), GLUL(2), GMPS(1), GPT(2), NAGK(1), PPAT(1) 9570754 31 28 29 8 1 4 8 13 5 0 0.414 0.994 1.000 350 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 GNAS(1), PLCE1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 3589483 5 5 5 6 1 0 1 1 2 0 0.995 0.994 1.000 351 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(2), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP7A(1), ATP7B(2), COX10(3), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFV1(1), SDHA(2) 9258553 27 27 26 7 1 3 3 13 7 0 0.635 0.994 1.000 352 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(1), AKT2(2), AKT3(1), BAD(1), CDKN2A(2), DAPP1(2), GSK3A(1), IGFBP1(1), PIK3CA(2), PTEN(5), RPS6KA1(1), RPS6KA3(2), SFN(1), SOS1(3), SOS2(1) 8705692 26 23 26 8 1 5 8 4 8 0 0.445 0.994 1.000 353 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASS1(1), CKB(1), CPS1(1), EPRS(2), GLUD2(6), LAP3(2), NOS1(1), NOS3(1), OAT(1), P4HA1(1), PRODH(1), RARS(1), RARS2(2) 8753469 23 21 21 5 2 1 5 11 4 0 0.378 0.995 1.000 354 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 BCAR1(1), CTNNA1(3), CTNNA2(1), PTK2(1), PXN(1), SRC(1) 4687079 8 8 8 3 0 1 2 2 3 0 0.735 0.995 1.000 355 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1) 2588115 1 1 1 0 0 0 0 1 0 0 0.835 0.995 1.000 356 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ACYP1(1), EHHADH(1), HADHA(2), PNPLA3(1), YOD1(1) 6258868 7 7 7 2 0 1 0 4 2 0 0.782 0.995 1.000 357 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TLR4(1), TNF(1), TNFAIP3(2), TNFRSF1B(1) 5923186 15 14 15 6 1 4 1 5 3 1 0.832 0.995 1.000 358 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(5), IL7R(1), JAK1(2), JAK3(1), PIK3CA(2), PIK3R1(2), STAT5A(1) 6783330 18 17 18 5 1 4 2 5 6 0 0.632 0.996 1.000 359 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(1), CCR3(2), CCR5(1), CCR7(1), IFNGR1(1), IL12RB1(1), IL4R(1) 4853861 8 7 8 4 0 0 1 4 3 0 0.936 0.996 1.000 360 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(2), AKT3(1), MAP2K2(1), NTRK1(2), PIK3CA(2), PIK3CD(1), SOS1(3) 3955810 13 10 13 5 2 3 1 5 2 0 0.599 0.996 1.000 361 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSD(1), ARSE(1), CYP11B1(1), SRD5A1(1), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1) 6593516 10 10 10 3 1 0 4 1 4 0 0.577 0.996 1.000 362 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(1), H6PD(2), PFKL(1), PFKP(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(1), TKT(1), TKTL2(1) 5898252 12 12 12 4 3 2 1 3 3 0 0.670 0.996 1.000 363 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 GABBR1(1), GPRC5D(1), GRM2(3), GRM4(3), GRM5(1) 5056128 9 8 9 3 3 3 0 2 1 0 0.425 0.996 1.000 364 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 TNF(1) 3246862 1 1 1 1 0 0 0 0 1 0 1.000 0.996 1.000 365 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(2), EPRS(2), LARS(4), MARS(1), MARS2(1), RARS(1) 7715743 12 11 12 3 1 1 1 4 5 0 0.758 0.996 1.000 366 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), NFKB1(1), PIK3CA(2), PIK3R1(2), RELA(1) 4710753 11 11 11 6 0 3 0 5 3 0 0.981 0.997 1.000 367 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 RELN(2), VLDLR(2) 3372780 4 4 4 4 1 1 0 1 1 0 0.987 0.997 1.000 368 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), IGF1R(1), PIK3CA(2), PIK3R1(2) 3200697 6 6 6 4 0 2 0 3 1 0 0.975 0.997 1.000 369 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(2), CREB3(1), DUSP6(2), EEF2K(3), MAP2K2(1), MAP3K8(1), NFKB1(1), RPS6KA1(1), RPS6KA3(2), SOS1(3), SOS2(1) 7193345 19 18 19 5 0 5 6 4 4 0 0.274 0.997 1.000 370 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA1(1), CA13(2), CA6(1), CA9(1), CPS1(1), CTH(1), GLS(2), GLUD2(6), GLUL(2) 5124413 18 18 16 7 0 2 4 9 3 0 0.829 0.997 1.000 371 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI3(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SHH(1), SUFU(2) 4030378 9 8 9 7 0 2 1 3 3 0 0.978 0.997 1.000 372 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(1), AR(3), ASAH1(1), BRAF(2), CAMP(1), DAG1(3), GNA11(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), MAPK10(1), PHKA2(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), RAF1(2), SRC(1) 12992358 33 30 33 7 1 6 5 13 8 0 0.393 0.998 1.000 373 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), CAP1(2), CCNB1(1), GNAS(1), GNB1(1), MYT1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SRC(1) 5015509 13 13 13 8 1 3 2 4 3 0 0.947 0.998 1.000 374 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 GNS(1), LCT(3) 3350889 4 4 4 3 1 0 0 2 1 0 0.956 0.998 1.000 375 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(2), CREBBP(4), CSNK2A1(2), CTBP1(1), FZD1(2), MAP3K7(1), NLK(1), WIF1(1) 7171725 15 14 15 9 2 2 1 5 4 1 0.962 0.998 1.000 376 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 AKT1(1), ASAH1(1), GNB1(1), ITGB3(2), PDGFRA(1), PIK3CA(2), PIK3R1(2), PLCB1(2), PTK2(1), SMPD1(3), SMPD2(1), SPHK1(2), SRC(1) 6615447 20 20 20 6 2 5 1 9 3 0 0.614 0.998 1.000 377 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), ASAH1(1), CAMP(1), CERK(1), CREB3(1), DAG1(3), ITPKA(1), ITPKB(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1) 6936340 13 12 13 6 2 0 4 2 5 0 0.931 0.998 1.000 378 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(2), AKT3(1), BAD(1), BCR(1), DAG1(3), ITPKA(1), ITPKB(1), LYN(1), MAP2K2(1), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PI3(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), PLCG2(2), RAF1(2), SOS1(3), SOS2(1), VAV1(1) 12813132 35 29 35 7 3 5 4 14 9 0 0.255 0.998 1.000 379 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BAK1(1), BID(1), BIRC3(1), CASP9(1), DIABLO(1) 3281438 6 6 6 3 1 2 1 1 1 0 0.808 0.998 1.000 380 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(1), AGPS(4), CDS2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GPD1(1), LCAT(2), LGALS13(1), PAFAH2(1), PLA2G4A(1), PLA2G6(1), PLCB2(2), PLCG1(1), PLCG2(2) 12263900 30 28 30 7 3 3 3 14 7 0 0.356 0.998 1.000 381 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(3), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BCKDHA(1), DBT(2), DLD(2), EHHADH(1), HADHA(2), HIBCH(1), HMGCL(1), HSD17B4(1), MCCC1(1), PCCA(1) 10472795 22 20 22 5 1 2 7 9 2 1 0.285 0.998 1.000 382 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), HPD(2), MAOA(1), MAOB(2), MPO(2), PRDX2(1), PRDX6(2) 5352490 15 14 15 5 4 1 3 5 2 0 0.614 0.998 1.000 383 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), IL12RB1(1), JAK2(1) 3585113 3 3 3 2 0 0 0 2 1 0 0.955 0.999 1.000 384 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(1), GCK(2), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), KHK(3), PFKFB3(2), PFKFB4(1), PFKP(1), TPI1(1) 5838795 16 14 16 6 0 2 3 7 4 0 0.837 0.999 1.000 385 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 GNAS(1), GNB1(1), IGF1R(1), ITGB1(2), MAP2K2(1), PDGFRA(1), PTPRR(1), RAF1(2), RPS6KA1(1), SOS1(3), SRC(1) 8076787 15 15 15 4 2 1 1 7 4 0 0.630 0.999 1.000 386 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2B(1), ENPP1(4), ENPP3(1), GAA(1), GBA3(1), GBE1(1), GCK(2), GYS2(2), HK1(1), MGAM(3), PGM1(1), PYGB(1), PYGL(1), PYGM(1), SI(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1) 13847306 31 26 31 6 5 1 5 14 6 0 0.315 0.999 1.000 387 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 PNPLA3(1) 3974463 1 1 1 1 0 1 0 0 0 0 0.889 0.999 1.000 388 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), PAK1(1), PLCG1(1), RAF1(2), SOS1(3), SRC(1) 6920918 14 13 14 7 0 2 0 7 5 0 0.963 0.999 1.000 389 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKB(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2) 4416481 10 10 10 4 1 3 0 4 2 0 0.854 0.999 1.000 390 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2B(2), GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(1), TAF10(1), TAF1L(2), TAF2(1), TAF4(2), TAF4B(3), TAF5L(1), TAF6(1), TAF7(1), TBPL2(1) 8742581 20 19 20 5 1 4 6 7 2 0 0.290 0.999 1.000 391 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPN1(1), ITGA1(3), ITGB1(2), ITGB3(2), PTK2(1), PXN(1), SPTAN1(4), SRC(1), TLN1(7) 6939909 23 21 23 7 0 3 3 12 5 0 0.722 0.999 1.000 392 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG7(1), IFNA16(1), IFNA2(1), INS(1), PIK3C3(1), PIK3R4(1), ULK1(1), ULK2(1) 5139746 8 8 8 4 1 1 0 4 2 0 0.935 0.999 1.000 393 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), JAK1(2), MAP3K1(2), PDGFRA(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1) 8446631 21 16 21 7 3 4 0 6 8 0 0.807 0.999 1.000 394 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(2), CYP2C8(1), CYP3A43(2), CYP3A7(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), RDH11(1), RDH13(1) 5805576 11 10 11 5 0 1 0 7 3 0 0.901 0.999 1.000 395 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), BAD(1), CASP9(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RAF1(2), RALBP1(1), RELA(1) 4663315 12 11 12 6 0 3 1 5 3 0 0.957 0.999 1.000 396 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ARPC2(1), NCKAP1(1), NTRK1(2), PIR(1), PSMA7(1), WASF1(1) 3695428 9 9 9 6 1 3 0 4 1 0 0.932 0.999 1.000 397 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(1), ATM(1), BAD(1), BID(1), CASP9(1), PTK2(1), PXN(1), STAT1(1), TLN1(7), TP53(4) 6626732 20 17 20 7 0 2 4 9 5 0 0.727 0.999 1.000 398 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PGAP1(5), PIGB(1), PIGF(1), PIGN(1), PIGQ(1) 5866760 10 10 10 4 0 3 2 5 0 0 0.687 0.999 1.000 399 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH4(1), ADH6(1), AGPAT1(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), LCT(3), LPL(1) 11798312 31 28 31 8 3 3 6 14 5 0 0.427 0.999 1.000 400 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1) 4669826 6 5 6 5 0 2 0 2 2 0 0.986 0.999 1.000 401 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IKBKB(1), IL1R1(1), IL1RN(1), MAP2K3(1), MAP3K1(2), MAP3K14(1), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1) 7191856 13 12 13 7 1 3 0 5 3 1 0.966 0.999 1.000 402 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(2), RELA(1) 4725646 7 7 7 7 1 1 0 3 2 0 0.999 0.999 1.000 403 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(3), CAMK1(2), HDAC5(3), IGF1R(1), INS(1), MAPK7(3), NFATC2(3), PIK3CA(2), PIK3R1(2), PPP3CA(1) 8455596 22 21 21 6 4 3 1 11 3 0 0.572 0.999 1.000 404 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(1), CSNK1E(3), PER1(1), PER2(2), PER3(1) 4164606 10 10 10 9 3 1 2 3 1 0 0.993 0.999 1.000 405 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(2), AKT3(1), ASAH1(1), BRAF(2), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), PI3(1), PIK3CB(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(3), SOS2(1), SRC(1) 14202557 35 31 35 8 2 5 6 12 10 0 0.338 1.000 1.000 406 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), GNB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), NFATC2(3), NFATC3(2), NFKB1(1), NFKBIA(2), PAK1(1), PIK3C2G(2), PLCB1(2), PPP3CA(1), RAF1(2), RELA(1) 9321538 24 23 24 6 3 3 1 10 7 0 0.701 1.000 1.000 407 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 IKBKB(1), MAP2K3(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1) 5893079 10 10 10 8 1 2 0 4 3 0 0.997 1.000 1.000 408 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(1), JAK1(2), MAP3K1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1) 9058720 21 17 21 7 2 4 0 7 8 0 0.830 1.000 1.000 409 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(1), BRCA1(2), CHEK1(1), MRE11A(1), NFKB1(1), NFKBIA(2), RBBP8(2), RELA(1), TP53(4) 7177486 18 15 18 9 2 1 0 11 4 0 0.948 1.000 1.000 410 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), MAP3K1(2), NFKB1(1), NSMAF(1), RAF1(2), RELA(1), SMPD1(3) 4971115 11 10 11 7 1 2 1 4 3 0 0.984 1.000 1.000 411 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), DDX20(3), ETS1(1), HDAC5(3), RBL2(2), SIN3A(2), SIN3B(1) 6450158 13 12 13 7 2 2 1 5 3 0 0.886 1.000 1.000 412 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(1), AP2A1(1), AP2M1(1), BIN1(2), DNM1(2), EPS15(1), PICALM(2), PPP3CA(1), SYNJ1(1) 5338197 12 11 12 6 1 0 5 4 2 0 0.897 1.000 1.000 413 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), LYN(1), MAP3K1(2), MAPK8IP3(1), PAPPA(3), RPS6KA1(1), RPS6KA3(2), SOS1(3), VAV1(1) 7792610 15 14 15 8 0 4 2 4 5 0 0.934 1.000 1.000 414 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 LYN(1), MAP3K1(2), NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1), RAF1(2), SOS1(3), VAV1(1) 9223530 16 15 16 5 1 2 0 6 7 0 0.856 1.000 1.000 415 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(1), ASAH1(1), CERK(1), GAL3ST1(1), GALC(2), GBA(1), LCT(3), SGMS1(1), SMPD1(3), SMPD2(1), SMPD4(2), SPHK1(2), SPTLC2(2) 8689615 23 20 23 7 3 4 1 10 5 0 0.590 1.000 1.000 416 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), CAPN2(2), EGF(1), ITGA1(3), ITGB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(7) 7985078 22 19 22 9 0 2 2 12 6 0 0.923 1.000 1.000 417 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), DCK(1), DPYD(1), DPYS(2), ENTPD1(1), POLB(1), POLD1(1), POLG(2), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2), TK2(1), TXNRD1(2), TYMS(1) 13987082 34 31 34 8 3 4 5 11 11 0 0.486 1.000 1.000 418 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 GNAS(1), GNB1(1), NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RAF1(2), RPS6KA3(2) 8464193 16 16 16 9 2 1 1 6 6 0 0.979 1.000 1.000 419 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), ETV5(2), IL12RB1(1), JAK2(1) 4530466 5 5 5 3 0 1 0 3 1 0 0.945 1.000 1.000 420 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS6ST2(1), NDST3(1) 5058638 7 7 7 3 1 0 2 3 1 0 0.822 1.000 1.000 421 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(1), ALG5(1), ALG6(1), ALG9(1), B4GALT1(1), DPAGT1(2), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), RFT1(1), RPN1(1), ST6GAL1(1) 10309749 14 11 14 3 1 3 2 2 6 0 0.355 1.000 1.000 422 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CALCRL(1), CD97(2), ELTD1(2), EMR2(1), GIPR(1), LPHN1(1), LPHN2(1), VIPR2(1) 6566110 11 10 11 5 1 1 3 3 3 0 0.927 1.000 1.000 423 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(1), ATR(3), BRCA1(2), CCNB1(1), CHEK1(1), EP300(5), MYT1(2), PRKDC(2), RPS6KA1(1), TP53(4) 10223912 22 21 22 8 0 3 2 10 7 0 0.834 1.000 1.000 424 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F12(4), F13B(1), F2(1), F5(3), F8(2), LPA(3), PLAU(1), PLG(2), SERPINB2(1), VWF(2) 8473457 21 19 21 8 2 2 3 9 5 0 0.880 1.000 1.000 425 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDT1(1), MCM10(2), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), NACA(1), POLD1(1), PRIM1(1), RFC1(1), RFC4(1), RFC5(2), RPA4(1), UBA52(1) 12298582 20 18 20 4 2 2 3 9 4 0 0.392 1.000 1.000 426 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPS(4), CHPT1(1), PAFAH1B2(1), PAFAH2(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1) 5653895 11 11 11 8 1 2 1 5 2 0 0.970 1.000 1.000 427 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 F2(1), F2R(1), GNB1(1), MAP3K7(1), PIK3CA(2), PIK3R1(2), PLCB1(2) 6245301 10 10 10 4 1 2 1 4 1 1 0.769 1.000 1.000 428 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 INS(1), IRS1(1), JAK2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RPS6KA1(1), SLC2A4(1), SOS1(3), STAT5A(1) 8012173 16 14 16 6 1 3 1 6 5 0 0.818 1.000 1.000 429 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), MAP3K1(2) 4232955 3 3 3 7 0 1 0 1 1 0 1.000 1.000 1.000 430 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), MAP2K2(1), MAP3K1(2), PAK1(1), PTK2(1), RAF1(2), SOS1(3), SRC(1) 8159348 14 13 14 7 0 3 1 5 5 0 0.927 1.000 1.000 431 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(3), ACYP1(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DLD(2), LDHB(1), MDH1(1), ME2(1), PC(5), PCK1(1) 8938640 21 18 21 7 1 2 7 6 4 1 0.688 1.000 1.000 432 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 FCER1G(1), LYN(1), MAP3K1(2), NFATC2(3), NFATC3(2), PIK3CA(2), PIK3R1(2), PLA2G4A(1), PLCG1(1), PPP3CA(1), RAF1(2), SOS1(3), VAV1(1) 10372563 22 21 22 9 1 4 0 9 8 0 0.937 1.000 1.000 433 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(1), AGXT2(1), ALAS2(2), AOC2(1), AOC3(1), CHDH(1), CTH(1), DLD(2), MAOA(1), MAOB(2), PIPOX(2), PSAT1(1), RDH11(1), RDH13(1), SARS2(1), SHMT2(2), TARS2(2) 10239805 23 23 23 9 2 3 2 10 5 1 0.885 1.000 1.000 434 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(1), DAG1(3), DGKA(1), GCA(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), PAK1(1), PDE3B(2), PI3(1), PIK3C2G(2), PIK3CA(2), PIK3CD(1), PIK3R1(2) 11870726 26 25 26 6 0 7 2 12 5 0 0.518 1.000 1.000 435 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKB(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TNFRSF1B(1) 5453860 11 11 11 5 1 4 0 4 2 0 0.889 1.000 1.000 436 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(1), ATR(3), CCNE1(1), CDKN2A(2), TP53(4) 7298237 14 13 14 7 1 1 1 8 3 0 0.892 1.000 1.000 437 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), MAPK7(3), NTRK1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RPS6KA1(1) 4660495 12 11 11 6 1 3 1 6 1 0 0.861 1.000 1.000 438 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 LIMK1(2), MAP3K1(2), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(2), RALBP1(1), TRIO(6), VAV1(1), WASF1(1) 8462840 19 18 19 8 2 5 1 6 5 0 0.888 1.000 1.000 439 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B1(1), HSD17B7(1), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), SRD5A1(1), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1) 12110428 21 19 21 8 1 0 5 6 9 0 0.795 1.000 1.000 440 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), DARS(2), EPRS(2), FARSA(1), IARS2(1), LARS(4), MARS(1), MARS2(1), NARS2(1), RARS(1), RARS2(2), SARS2(1), TARS2(2), VARS(2), VARS2(3), YARS2(1) 13114625 27 24 27 6 2 3 3 12 7 0 0.451 1.000 1.000 441 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(2), AKT3(1), CISH(2), IL4R(1), JAK1(2), JAK2(1), JAK3(1), PI3(1), PIK3CA(2), SOS1(3), SOS2(1), SRC(1), STAT6(1) 8944386 20 16 20 5 2 4 2 8 4 0 0.359 1.000 1.000 442 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), AMDHD1(1), AOC2(1), AOC3(1), HDC(1), HNMT(1), MAOA(1), MAOB(2), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), PRPS2(1) 9651399 24 20 24 7 4 3 4 8 5 0 0.455 1.000 1.000 443 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 GNS(1), HGSNAT(1), HPSE(1), HYAL1(1), LCT(3), SPAM1(1) 4850685 8 8 8 6 1 0 0 6 1 0 0.974 1.000 1.000 444 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC3(1), MAP3K7(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), RALBP1(1), TNF(1), TNFAIP3(2), TNFRSF1B(1) 6648870 13 12 13 6 2 3 0 6 1 1 0.821 1.000 1.000 445 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(2), APC(1), AXIN1(2), FZD1(2), NOTCH1(5) 5221564 12 12 12 5 2 3 0 6 1 0 0.777 1.000 1.000 446 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(2), CD1C(1), CD36(1), CD59(1), CR2(1), CSF1R(1), CSF2RA(1), CSF3R(1), EPOR(2), FCER2(1), FCGR1A(2), GP9(1), IL1R1(1), IL1R2(2), IL4R(1), IL5RA(2), IL7R(1), IL9R(3), ITGA1(3), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGAM(3), ITGB3(2), TFRC(1), THPO(1), TNF(1) 19875860 42 36 42 9 4 3 4 20 11 0 0.441 1.000 1.000 447 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), ASAH1(1), CAMP(1), DAG1(3), DLG4(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), RYR1(7) 11186250 22 22 22 6 4 2 5 8 3 0 0.517 1.000 1.000 448 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 AKT1(1), AURKB(1), BMPR1A(1), BUB1(1), CDKL2(3), CDS2(1), CLK1(1), CLK4(2), COL4A3BP(1), CSNK2A1(2), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP4B(2), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(1), OCRL(1), PAK4(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(2), PIK3CB(1), PIK3CG(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCG1(1), PLCG2(2), PRKACA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), PRKD1(1), PRKG1(1), RAF1(2), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), STK11(2), TGFBR1(1), VRK1(1) 27598330 81 64 81 14 7 13 7 31 23 0 0.0372 1.000 1.000 449 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), GNB1(1), NFKB1(1), PIK3C2G(2), PIK3CA(2), PIK3R1(2), PLCG1(1), PTK2(1), PXN(1), RAF1(2), RELA(1) 6770487 15 14 15 7 0 4 1 6 4 0 0.937 1.000 1.000 450 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 DCXR(1), RPE(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1) 6540850 11 11 11 5 0 1 4 4 2 0 0.864 1.000 1.000 451 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), AXIN1(2), CSNK1E(3), FZD1(2), FZD10(1), FZD5(1), FZD7(1), LDLR(1), MAPK10(1), PLAU(1), PPP2R5C(2), PPP2R5E(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PRKD1(1), WNT10A(2), WNT10B(1), WNT3(1) 14432597 33 29 33 8 4 4 2 15 8 0 0.382 1.000 1.000 452 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(2), CREBBP(4), EP300(5), FZD1(2), LDB1(1), LEF1(1) 8021683 16 15 16 7 1 2 2 7 4 0 0.890 1.000 1.000 453 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB3(1), EEF2K(3), IL1R1(1), MAP2K3(1), MAP3K10(1), MAP3K4(1), MAP3K7(1), MYEF2(1), NFKB1(1) 8144194 12 11 12 8 0 3 1 5 2 1 0.950 1.000 1.000 454 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC10(1), ANAPC4(1), ANAPC5(2), CDC16(1), CDC20(2), CUL1(2), CUL2(1), FBXW11(1), FBXW7(2), UBA1(1), VHL(2), WWP1(6), WWP2(1) 9003487 23 20 23 7 3 2 4 9 5 0 0.713 1.000 1.000 455 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(3), ASH2L(1), CTCFL(3), DOT1L(6), EED(1), EHMT1(1), EHMT2(3), EZH1(1), FBXO11(3), KDM6A(7), MLL(1), MLL2(12), MLL3(15), MLL4(3), MLL5(3), NSD1(5), OGT(1), PAXIP1(3), PPP1CA(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), RBBP5(1), SATB1(2), SETD1A(3), SETD2(11), SETDB1(2), SUV39H2(1), SUV420H1(1), SUZ12(1), WHSC1(1), WHSC1L1(1) 29461631 106 71 106 18 7 11 10 38 38 2 0.104 1.000 1.000 456 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), BCAR1(1), BCR(1), CAPN1(1), CRKL(1), ITGA1(3), ITGB1(2), MAP2K2(1), PTK2(1), PXN(1), RAF1(2), SOS1(3), SRC(1), TLN1(7) 11484977 26 24 26 8 0 3 2 13 8 0 0.794 1.000 1.000 457 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BID(1), BIRC3(1), CASP10(1), CASP9(1), GAS2(1), MAP3K14(1), NFKB1(1), NFKBIA(2), RELA(1), SPTAN1(4), TNFRSF25(1), TNFSF10(3) 8154011 19 18 19 8 1 3 3 8 4 0 0.883 1.000 1.000 458 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(3), ACACB(1), ACSS1(1), ACYP1(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DLD(2), LDHB(1), MDH1(1), ME2(1), PC(5), PCK1(1), PCK2(1) 11313483 24 21 24 8 1 3 7 7 5 1 0.703 1.000 1.000 459 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACMSD(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), CYP1B1(1), EHHADH(1), HAAO(1), HADHA(2), HSD17B4(1), KYNU(1), LNX1(1), MAOA(1), MAOB(2), METTL2B(1), NFX1(2), OGDH(5), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), TPH2(1) 14680834 35 28 35 9 3 6 5 13 8 0 0.336 1.000 1.000 460 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3), F10(1), F12(4), F2(1), F2R(1), F5(3), F8(2), PROS1(1) 10807039 22 20 22 8 1 2 4 10 5 0 0.760 1.000 1.000 461 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 AGXT(1), AGXT2(1), ALAS2(2), AOC2(1), AOC3(1), CHDH(1), CTH(1), DLD(2), MAOA(1), MAOB(2), PLCB2(2), PLCG1(1), PLCG2(2), SHMT2(2) 10067950 20 20 20 7 3 2 2 9 3 1 0.774 1.000 1.000 462 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 IKBKB(1), MAP2K3(1), MAP3K1(2), MAP3K14(1), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TLR10(1), TLR3(1), TLR4(1), TLR6(1), TLR7(1) 8831194 15 14 15 8 1 2 1 8 2 1 0.951 1.000 1.000 463 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(1), GAA(1), GALE(1), GCK(2), HK1(1), LCT(3), MGAM(3), PFKP(1), PGM1(1) 7941793 14 13 14 7 3 0 0 7 4 0 0.978 1.000 1.000 464 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(3), ESR2(1), ESRRA(1), HNF4A(2), NR1D2(1), NR2E1(1), NR2F1(1), NR2F2(2), NR2F6(1), NR3C1(2), PGR(1), RARG(1), RORA(1), RORC(1) 10254921 21 20 21 6 2 3 4 11 1 0 0.574 1.000 1.000 465 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), AXIN1(2), BMP7(1), BMPR1A(1), CHRD(1), FZD1(2), MAP3K7(1), NKX2-5(3), NOG(1), RFC1(1), TGFBR1(1), TGFBR2(1) 8825974 16 15 16 8 3 1 0 9 2 1 0.934 1.000 1.000 466 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(1), CAMK2A(1), CLCA1(1), CNGA3(1), CNGA4(1), GUCA1B(1), PDE1C(1), PRKACA(1), PRKACG(1), PRKG1(1), PRKG2(1), PRKX(1) 7427894 15 15 15 9 3 2 1 7 2 0 0.935 1.000 1.000 467 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(1), ADH4(1), ADH6(1), PNPLA3(1) 6007087 6 6 6 3 0 2 0 4 0 0 0.859 1.000 1.000 468 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(3), EPRS(2), HMOX1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UROD(1) 6609167 11 11 11 6 0 1 4 5 1 0 0.906 1.000 1.000 469 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GAPDH(2), GCK(2), HK1(1), LDHB(1), PFKP(1), PGM1(1), TPI1(1) 11807752 25 22 25 9 3 1 7 8 5 1 0.747 1.000 1.000 470 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GAPDH(2), GCK(2), HK1(1), LDHB(1), PFKP(1), PGM1(1), TPI1(1) 11807752 25 22 25 9 3 1 7 8 5 1 0.747 1.000 1.000 471 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), AP2M1(1), BAD(1), EEA1(1), GSK3A(1), LYN(1), PFKL(1), PFKP(1), PLCG1(1), PRKCE(2) 6023795 12 12 12 8 0 1 4 6 1 0 0.983 1.000 1.000 472 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(1), GMDS(1), GMPPA(1), GMPPB(2), HK1(1), KHK(3), MTMR2(2), MTMR6(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKP(1), PHPT1(1), RDH11(1), RDH13(1), TPI1(1) 9108745 21 20 21 9 0 5 4 8 4 0 0.819 1.000 1.000 473 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(1), CAMK2A(1), F2(1), GNA11(1), GNB1(1), JAK2(1), MAP2K2(1), PLCG1(1), RAF1(2), SOS1(3), STAT1(1), STAT5A(1) 10160872 18 16 18 7 1 2 0 10 5 0 0.865 1.000 1.000 474 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP5(2), ARHGEF5(1), ARPC2(1), BAIAP2(1), DIAPH1(2), GSN(2), LIMK1(2), PIP5K1B(1), SRC(1), TLN1(7) 11143687 21 18 21 6 1 3 3 8 6 0 0.638 1.000 1.000 475 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(1), CBX3(1), CLOCK(2), CRY1(1), EIF4G2(1), GSTP1(2), HERPUD1(2), HSPA8(1), NCKAP1(1), NCOA4(2), NR1D2(1), PER1(1), PER2(2), PIGF(1), PPP2CB(1), TOB1(3), ZFR(1) 8897726 24 21 24 8 1 2 6 11 4 0 0.784 1.000 1.000 476 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(1), ATM(1), ATR(3), BAI1(2), BID(1), CASP9(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN2A(2), CHEK1(1), GADD45B(1), GTSE1(2), PPM1D(2), PTEN(5), RCHY1(2), RFWD2(1), SERPINB5(1), SESN1(1), SFN(1), THBS1(4), TP53(4), TSC2(4), ZMAT3(1) 15880604 47 41 47 10 3 6 10 13 15 0 0.157 1.000 1.000 477 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(1), BMPR1B(1), DAZL(1), ESR2(1), MLH1(1), NCOR1(3), PGR(1), PRLR(1), SMPD1(3), ZP2(3) 8437678 16 14 16 6 1 4 1 8 2 0 0.727 1.000 1.000 478 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ACSM1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCL(1), HSD17B4(1), ILVBL(1), PRDX6(2), RDH11(1), RDH13(1) 9877092 21 21 21 7 1 3 5 10 2 0 0.632 1.000 1.000 479 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), HPD(2), MAOA(1), MAOB(2), MPO(2), PNPLA3(1), PRDX6(2) 8275947 15 14 15 5 4 2 2 5 2 0 0.606 1.000 1.000 480 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT2(2), AKT3(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PIK3CB(1) 10948352 25 24 25 8 4 3 4 10 4 0 0.579 1.000 1.000 481 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH4(1), ADH6(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HGD(1), HPD(2), MAOA(1), MAOB(2) 7697629 12 12 12 6 3 1 0 7 1 0 0.885 1.000 1.000 482 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(1), CCNB1(1), CCNE1(1), CCNE2(1), CCNG2(1), CDKN2A(2), CREB3(1), CREB3L3(1), E2F2(1), E2F3(1), GBA2(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), MYT1(2), NACA(1), PRIM1(1), TNXB(5), TP53(4) 18732408 31 29 31 7 4 3 6 13 5 0 0.166 1.000 1.000 483 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(1), CLK4(2), CPSF1(1), CPSF3(1), CSTF2T(1), DDX20(3), DHX16(1), DHX38(3), DHX9(3), DICER1(1), GIPC1(1), POLR2A(3), PRPF18(2), PRPF4B(4), PRPF8(3), RBM17(2), RBM5(1), RNMT(2), RNPS1(1), SF3A1(1), SF3B2(3), SF3B4(1), SNRPE(1), SRRM1(3), SUPT5H(3), U2AF2(1), XRN2(1) 25035062 51 42 51 9 6 8 5 22 10 0 0.197 1.000 1.000 484 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CEL(2), DAK(1), DGAT1(2), DGAT2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GPAM(2), LCT(3), LIPA(1), LPL(1), PNPLA3(1) 14344541 38 35 38 10 3 4 7 17 7 0 0.393 1.000 1.000 485 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(1), ATR(3), BRCA1(2), BRCA2(6), CHEK1(1), FANCA(1), FANCG(1), MRE11A(1), TP53(4), TREX1(1) 10612737 21 18 21 7 0 2 3 13 3 0 0.705 1.000 1.000 486 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(3), ADCY9(2), ARF3(1), ARF5(1), ATP6V0A4(1), ATP6V1A(1), GNAS(1), PLCG1(1), PLCG2(2), SEC61B(1), TRIM23(2) 8996297 17 16 17 8 4 1 1 9 2 0 0.852 1.000 1.000 487 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(2), CACNA1A(5), GNA11(1), GNAI2(1), GNAI3(1), GNAS(1), GNAZ(1), GRIA1(2), GRID2(3), GRM5(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), IGF1R(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), LYN(1), MAP2K2(1), NOS1(1), NOS3(1), NPR2(1), NRAS(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCG(3), PRKG1(1), PRKG2(1), RAF1(2), RYR1(7) 26922891 69 55 68 13 10 9 11 28 11 0 0.0630 1.000 1.000 488 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(1), ATP13A2(2), DDX23(1), DDX4(1), DDX41(3), DDX47(2), DDX50(2), DDX51(1), DDX52(1), DDX54(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(5), ERCC3(3), IFIH1(2), NUDT5(1), RAD54B(1), RUVBL2(1), SETX(2), SKIV2L2(1), SMARCA5(2) 15223548 42 38 42 10 2 6 9 22 3 0 0.255 1.000 1.000 489 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 FUCA1(2), GBA(1), GNS(1), HGSNAT(1), HPSE(1), HYAL1(1), LCT(3), MAN2B1(1), MANBA(1), SPAM1(1) 8303799 13 12 13 7 2 0 1 9 1 0 0.914 1.000 1.000 490 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(2), AKT3(1), CARD11(2), CBL(1), CBLB(1), CBLC(1), CTLA4(2), ICOS(1), IKBKB(1), KRAS(2), LAT(1), LCP2(2), MALT1(1), MAP3K14(1), MAP3K8(1), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NRAS(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PPP3CA(1), PRKCQ(1), PTPRC(2), RASGRP1(1), SOS1(3), SOS2(1), TNF(1), VAV1(1), ZAP70(1) 24613187 62 51 61 12 5 12 9 23 13 0 0.0712 1.000 1.000 491 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH4(1), ADH6(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HGD(1), HPD(2), MAOA(1), MAOB(2), METTL2B(1), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), TYRP1(2) 14395058 21 19 21 8 3 2 1 10 5 0 0.769 1.000 1.000 492 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(2), AKT3(1), APC(1), AXIN1(2), GSK3A(1), LRP1(1), MVP(1), NKD1(2), NKD2(2), PTPRA(1), WIF1(1) 9842146 16 16 16 7 2 2 2 9 1 0 0.831 1.000 1.000 493 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(1), AKT1(1), AKT2(2), AKT3(1), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(1), CBL(1), CBLB(1), CBLC(1), CRKL(1), EGF(1), EIF4EBP1(1), ERBB2(3), ERBB3(1), ERBB4(3), GAB1(1), KRAS(2), MAP2K2(1), MAPK10(1), NCK2(1), NRAS(1), NRG1(2), NRG2(1), NRG3(3), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PRKCG(3), PTK2(1), RAF1(2), SHC2(3), SHC4(1), SOS1(3), SOS2(1), SRC(1), STAT5A(1), TGFA(1) 25068808 74 55 73 16 6 12 14 32 10 0 0.117 1.000 1.000 494 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BID(1), BRAF(2), FASLG(2), FCER1G(1), HLA-A(1), HLA-B(2), HLA-C(1), ICAM1(1), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), ITGAL(2), ITGB2(1), KIR2DL4(1), KIR3DL2(1), KLRC1(1), KLRC2(1), KLRC3(1), KRAS(2), LAT(1), LCP2(2), MAP2K2(1), MICB(1), NCR2(1), NFAT5(1), NFATC2(3), NFATC3(2), NRAS(1), PAK1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PPP3CA(1), PRKCG(3), PTPN11(1), RAC2(1), RAF1(2), SH3BP2(4), SHC2(3), SHC4(1), SOS1(3), SOS2(1), TNF(1), TNFSF10(3), ULBP1(2), VAV1(1), ZAP70(1) 27511039 80 56 79 15 3 14 10 31 22 0 0.0729 1.000 1.000 495 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), AVPR2(1), C3AR1(2), CCKAR(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CCR7(1), GRPR(1), NPY2R(1), NTSR1(1), SSTR1(2), SSTR3(1), SSTR4(2), TACR2(1) 12559248 21 19 21 8 2 3 3 10 3 0 0.702 1.000 1.000 496 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR2A(3), AMH(1), AMHR2(2), BMP7(1), BMPR1A(1), BMPR1B(1), CCR2(1), CCR3(2), CCR5(1), CCR7(1), CD27(2), CD40(1), CNTF(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(2), CXCL1(1), EDA(1), EGF(1), EPOR(2), FASLG(2), FLT1(1), FLT4(3), GDF5(2), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), IL10RA(4), IL12RB1(1), IL15RA(1), IL17RB(2), IL1R1(1), IL1R2(2), IL21R(2), IL22RA1(2), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(3), INHBB(1), KDR(1), LEPR(1), LIFR(3), OSM(1), PDGFRA(1), PDGFRB(2), PRLR(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF19(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TNFSF15(1), TNFSF8(1) 42401123 93 72 93 18 7 12 15 38 21 0 0.0893 1.000 1.000 497 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4B(2), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(1), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PTEN(5), SYNJ1(1) 18088391 43 38 42 11 3 5 8 15 12 0 0.440 1.000 1.000 498 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(2), AKT3(1), BAD(1), BCR(1), CD81(1), CR2(1), DAG1(3), GSK3A(1), ITPR1(2), ITPR2(3), ITPR3(1), LYN(1), MAP4K1(2), NFATC2(3), PIK3CA(2), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP3CA(1), PTPRC(2), RAF1(2), SOS1(3), SOS2(1), VAV1(1) 17908774 41 36 41 11 2 6 6 16 11 0 0.582 1.000 1.000 499 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GNT1(1), B4GALT1(1), FUT2(1), FUT4(1), FUT6(1), FUT7(1), PIGB(1), PIGF(1), PIGN(1), PIGQ(1), ST3GAL4(1), ST6GALNAC5(2) 11837878 13 12 13 7 1 3 1 7 1 0 0.887 1.000 1.000 500 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(4), CDR1(2), FAU(2), IL6ST(3), RPL10(1), RPL11(1), RPL13(1), RPL14(1), RPL18(1), RPL19(1), RPL22(1), RPL24(1), RPL26(1), RPL3(2), RPL3L(1), RPL6(1), RPL7A(3), RPS14(1), RPS2(1), RPS24(1), RPS6KA1(1), RPS6KA3(2), RPS7(1), RPS8(1), RPSA(1), SLC36A2(1), UBA52(1) 12656260 38 36 36 10 2 4 7 15 10 0 0.498 1.000 1.000 501 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2B(1), ASCC3(1), ATP13A2(2), DDX23(1), DDX4(1), DDX41(3), DDX47(2), DDX50(2), DDX51(1), DDX52(1), DDX54(1), DDX56(1), DHX58(1), ENPP1(4), ENPP3(1), ENTPD7(3), EP400(5), ERCC3(3), GAA(1), GBA(1), GBA3(1), GBE1(1), GCK(2), GYS2(2), HK1(1), IFIH1(2), MGAM(3), NUDT5(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), RAD54B(1), RUVBL2(1), SETX(2), SI(2), SKIV2L2(1), SMARCA5(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1) 29986222 74 55 74 16 6 5 13 40 10 0 0.218 1.000 1.000 502 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACYP1(1), ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GALM(1), GAPDH(2), GAPDHS(2), GCK(2), HK1(1), LDHB(1), PFKL(1), PFKP(1), PGAM2(1), PGK2(1), PGM1(1), TPI1(1) 14089883 32 29 32 10 3 2 7 11 8 1 0.633 1.000 1.000 503 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(2), AKT3(1), BCR(1), CDKN2A(2), DAPP1(2), GAB1(1), ITPR1(2), ITPR2(3), ITPR3(1), LYN(1), PHF11(1), PIK3CA(2), PLCG2(2), PREX1(1), PTEN(5), PTPRC(2), RPS6KA1(1), RPS6KA3(2), VAV1(1) 13441467 34 30 34 10 1 5 6 12 10 0 0.477 1.000 1.000 504 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(2), AKT3(1), BAD(1), CASP9(1), KDR(1), KRAS(2), MAP2K2(1), NFAT5(1), NFATC2(3), NFATC3(2), NOS3(1), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCG1(1), PLCG2(2), PPP3CA(1), PRKCG(3), PTGS2(1), PTK2(1), PXN(1), RAC2(1), RAF1(2), SHC2(3), SPHK1(2), SRC(1) 17592569 49 39 48 13 3 8 8 19 11 0 0.528 1.000 1.000 505 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), C1S(1), C3(1), C3AR1(2), C4BPB(1), C5AR1(1), C6(2), C7(1), CD46(1), CD59(1), CFB(1), CFD(1), CFH(1), CFI(1), CPB2(1), CR2(1), F10(1), F12(4), F13A1(2), F13B(1), F2(1), F2R(1), F5(3), F8(2), KNG1(2), MASP1(1), MBL2(1), PLAU(1), PLG(2), PROS1(1), SERPINA1(1), SERPIND1(1), TFPI(1), THBD(1), VWF(2) 21931057 48 39 48 13 5 5 4 27 7 0 0.622 1.000 1.000 506 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(1), APC2(1), AXIN1(2), CACYBP(1), CAMK2A(1), CHD8(3), CREBBP(4), CSNK1E(3), CSNK2A1(2), CTBP1(1), CUL1(2), DAAM1(1), EP300(5), FBXW11(1), FZD1(2), FZD10(1), FZD4(1), FZD5(1), FZD7(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), NFAT5(1), NFATC2(3), NFATC3(2), NKD1(2), NKD2(2), NLK(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PORCN(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP3CA(1), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKX(1), RAC2(1), ROCK2(1), SFRP5(1), SMAD4(2), TBL1X(1), TBL1XR1(2), TCF7L1(1), TP53(4), VANGL1(3), WIF1(1), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1) 39249468 100 75 100 23 9 12 14 37 27 1 0.165 1.000 1.000 507 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG10B(1), ALG6(1), ALG9(1), B3GNT1(1), B3GNT6(3), B4GALT1(1), CHPF(1), CHST2(1), CHST3(1), CHST6(1), CHST7(1), DPAGT1(2), FUT11(2), GALNT10(2), GALNT11(1), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(1), GALNT6(2), GALNT7(1), GALNTL5(1), GCNT3(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS6ST2(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), NDST3(1), OGT(1), RPN1(1), ST3GAL4(1), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(2) 26809766 49 39 48 11 6 7 10 13 13 0 0.153 1.000 1.000 508 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP4B(2), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(1), PI4KA(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PRKCG(3), PTEN(5), SYNJ1(1) 30492909 75 61 74 18 4 13 11 30 17 0 0.246 1.000 1.000 509 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR2A(3), AMH(1), AMHR2(2), BMP7(1), BMP8A(1), BMPR1A(1), BMPR1B(1), CHRD(1), CREBBP(4), CUL1(2), EP300(5), GDF5(2), INHBB(1), LEFTY1(1), LTBP1(5), NODAL(1), NOG(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), RBL2(2), ROCK2(1), SMAD1(1), SMAD4(2), SMAD6(1), SMAD7(1), TGFBR1(1), TGFBR2(1), THBS1(4), THBS2(2), THBS3(1), TNF(1), ZFYVE9(1) 24027586 58 46 57 16 6 9 14 16 13 0 0.365 1.000 1.000 510 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(2), AKT3(1), CBL(1), CBLB(1), CBLC(1), CISH(2), CNTF(1), CREBBP(4), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(5), EPOR(2), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), IL10RA(4), IL12RB1(1), IL15RA(1), IL21R(2), IL22RA1(2), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(3), JAK1(2), JAK2(1), JAK3(1), LEPR(1), LIFR(3), OSM(1), PIAS1(1), PIAS2(1), PIAS3(1), PIAS4(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PRLR(1), PTPN11(1), SOCS5(1), SOS1(3), SOS2(1), SPRED2(1), SPRY2(1), STAM(2), STAT1(1), STAT5A(1), STAT6(1) 35251528 85 64 85 19 6 14 14 31 20 0 0.196 1.000 1.000 511 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADK(1), ADSL(2), AMPD2(2), ATP5A1(1), ATP5B(1), ATP5F1(1), DCK(1), ENPP1(4), ENPP3(1), ENTPD1(1), GART(2), GMPS(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), NPR2(1), PAPSS2(2), PDE4A(1), PDE5A(4), PDE6B(2), PDE6C(1), PDE7B(1), PDE9A(2), PFAS(1), POLB(1), POLD1(1), POLG(2), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2), PPAT(1), PRPS2(1), PRUNE(1) 31069063 76 60 76 19 7 14 11 28 16 0 0.284 1.000 1.000 512 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTG1(1), AKT1(1), AKT2(2), AKT3(1), ARHGAP5(2), BAD(1), BCAR1(1), BIRC3(1), BRAF(2), CAPN2(2), CAV2(1), CHAD(1), COL11A1(1), COL11A2(1), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), CRKL(1), DIAPH1(2), DOCK1(2), EGF(1), ERBB2(3), FARP2(1), FLNA(1), FLNB(2), FLNC(4), FLT1(1), FN1(4), IGF1R(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), KDR(1), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), MAPK10(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP5K1C(2), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PRKCG(3), PTEN(5), PTK2(1), PXN(1), RAC2(1), RAF1(2), RAPGEF1(1), RELN(2), ROCK2(1), SHC2(3), SHC4(1), SOS1(3), SOS2(1), SRC(1), THBS1(4), THBS2(2), THBS3(1), TLN1(7), TLN2(3), TNC(3), TNR(1), TNXB(5), VAV1(1), VWF(2) 89771519 201 109 201 56 11 23 34 84 48 1 0.453 1.000 1.000 513 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 APC(1), APC2(1), ARAF(1), ARHGEF12(3), ARHGEF4(2), ARHGEF6(2), ARPC2(1), BAIAP2(1), BCAR1(1), BRAF(2), CFL2(1), CHRM1(2), CHRM2(2), CHRM3(1), CRKL(1), CYFIP1(1), CYFIP2(1), DIAPH1(2), DIAPH3(2), DOCK1(2), EGF(1), EZR(1), F2(1), F2R(1), FGF1(2), FGF10(1), FGF12(1), FGF19(1), FGF21(1), FGF3(3), FGF6(1), FGFR1(1), FGFR3(6), FN1(4), GIT1(1), GNG12(1), GSN(2), INS(1), IQGAP1(1), IQGAP2(4), IQGAP3(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGAD(2), ITGAE(1), ITGAL(2), ITGAM(3), ITGAX(4), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), KRAS(2), LIMK1(2), LIMK2(2), MAP2K2(1), MSN(1), MYH10(1), MYH14(1), MYH9(2), NCKAP1(1), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PDGFRA(1), PDGFRB(2), PFN3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PTK2(1), PXN(1), RAC2(1), RAF1(2), RDX(1), ROCK2(1), SCIN(2), SOS1(3), SOS2(1), SSH2(4), TIAM1(1), VAV1(1), WASF1(1) 67723155 168 101 166 43 17 28 20 72 31 0 0.141 1.000 1.000 514 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 AKT1(1), AKT2(2), AKT3(1), ARRB1(2), BDNF(1), BRAF(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1G(2), CACNA1H(2), CACNA1I(3), CACNA1S(5), CACNA2D1(1), CACNA2D4(1), CACNB1(2), CACNB4(1), CACNG2(2), CACNG4(1), CACNG8(1), CRKL(1), DAXX(1), DUSP6(2), ECSIT(1), EGF(1), ELK4(1), FASLG(2), FGF1(2), FGF10(1), FGF12(1), FGF19(1), FGF21(1), FGF3(3), FGF6(1), FGFR1(1), FGFR3(6), FLNA(1), FLNB(2), FLNC(4), GADD45B(1), GNG12(1), IKBKB(1), IL1R1(1), IL1R2(2), KRAS(2), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K14(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K8(1), MAP4K1(2), MAP4K3(2), MAPK10(1), MAPK7(3), MAPK8IP1(1), MAPK8IP3(1), NF1(1), NFATC2(3), NFKB1(1), NFKB2(2), NLK(1), NRAS(1), NTRK1(2), NTRK2(1), PAK1(1), PDGFRA(1), PDGFRB(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PPM1A(3), PPP3CA(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKX(1), PTPRR(1), RAC2(1), RAF1(2), RAPGEF2(1), RASA1(2), RASA2(1), RASGRF1(3), RASGRP1(1), RASGRP3(1), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), SOS1(3), SOS2(1), TAOK3(1), TGFBR1(1), TGFBR2(1), TNF(1), TP53(4) 70433364 163 97 161 52 17 16 26 68 34 2 0.760 1.000 1.000 515 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY2(2), ADCY3(3), ADCY8(3), ADCY9(2), ADORA2A(2), ATP2A1(1), ATP2A2(1), ATP2B1(2), BST1(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1G(2), CACNA1H(2), CACNA1I(3), CACNA1S(5), CAMK2A(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(2), CHRM3(1), ERBB2(3), ERBB3(1), ERBB4(3), F2R(1), GNA11(1), GNAS(1), GRIN2A(2), GRIN2D(1), GRM5(1), GRPR(1), HTR2B(1), HTR6(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NOS1(1), NOS3(1), NTSR1(1), P2RX1(1), P2RX2(1), P2RX5(1), P2RX7(1), PDE1C(1), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PPP3CA(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKX(1), PTGFR(2), RYR1(7), RYR2(6), RYR3(5), SLC25A5(1), SLC8A1(2), SLC8A2(1), SLC8A3(1), SPHK1(2), TACR2(1), VDAC2(1), VDAC3(1) 66256450 146 95 145 45 21 26 19 54 26 0 0.338 1.000 1.000 516 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ANXA6(1), ARRB1(2), ATP2A2(1), ATP2B1(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1S(5), CACNB1(2), CALR(1), CAMK1(2), CAMK2A(1), CHRM1(2), CHRM2(2), CHRM3(1), GJB5(1), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(1), GNB1(1), GNG12(1), GRK4(1), GRK5(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), MIB1(1), NME7(1), PKIB(1), PLCB3(1), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS16(1), RGS20(1), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(7), RYR2(6), RYR3(5), SFN(1), SLC8A1(2), SLC8A3(1), USP5(2) 45863099 111 81 111 38 16 17 13 40 25 0 0.592 1.000 1.000 517 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(1), CHAD(1), COL11A1(1), COL11A2(1), COL17A1(2), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), DES(1), DSC2(2), DSC3(2), DSG3(1), DSG4(2), FN1(4), GJA3(1), GJB5(1), GJC1(1), ITGA6(2), ITGB4(4), KRT1(1), KRT10(1), KRT13(3), KRT17(1), KRT18(1), KRT2(1), KRT23(1), KRT27(2), KRT32(1), KRT33A(1), KRT35(2), KRT37(1), KRT38(1), KRT4(2), KRT40(1), KRT6A(1), KRT6B(1), KRT75(1), KRT76(1), KRT77(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), KRT9(2), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), PRPH(2), RELN(2), THBS1(4), THBS2(2), THBS3(1), TNC(3), TNR(1), TNXB(5), VIM(1), VWF(2) 60659946 135 81 135 45 9 15 17 65 28 1 0.777 1.000 1.000 518 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CHAD(1), COL11A1(1), COL11A2(1), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), DAG1(3), FN1(4), FNDC1(1), GP9(1), HSPG2(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), RELN(2), SDC2(1), SDC4(1), SV2B(2), SV2C(1), THBS1(4), THBS2(2), THBS3(1), TNC(3), TNR(1), TNXB(5), VWF(2) 54936826 119 81 119 36 7 13 18 52 28 1 0.597 1.000 1.000 519 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(3), ACACB(1), AKT1(1), AKT2(2), AKT3(1), ARAF(1), BAD(1), BRAF(2), CBL(1), CBLB(1), CBLC(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(5), FOXO1(2), GCK(2), GYS2(2), IKBKB(1), INS(1), IRS1(1), IRS2(2), KRAS(2), LIPE(1), MAP2K2(1), MAPK10(1), NRAS(1), PCK1(1), PCK2(1), PDE3B(2), PFKL(1), PFKP(1), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PPARGC1A(1), PPP1CA(1), PPP1CC(1), PPP1R3A(1), PRKACA(1), PRKACG(1), PRKAG2(2), PRKAR2A(1), PRKAR2B(1), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(3), PYGB(1), PYGL(1), PYGM(1), RAF1(2), RAPGEF1(1), RHEB(1), SH2B2(1), SHC2(3), SHC4(1), SLC2A4(1), SORBS1(2), SOS1(3), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(4) 39240503 111 80 110 31 8 26 16 42 19 0 0.164 1.000 1.000 520 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADORA2A(2), ADORA3(1), AGTR2(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), F2(1), F2R(1), F2RL2(1), GABBR1(1), GABRB2(1), GABRB3(1), GABRD(1), GABRG1(1), GABRG2(1), GABRG3(3), GABRQ(1), GIPR(1), GLRA2(1), GPR50(1), GPR83(1), GRIA1(2), GRID1(1), GRID2(3), GRIK1(1), GRIK2(1), GRIK3(2), GRIK5(1), GRIN2A(2), GRIN2B(1), GRIN2D(1), GRIN3A(1), GRIN3B(2), GRM2(3), GRM4(3), GRM5(1), GRPR(1), HCRTR2(4), HRH3(1), HTR1B(1), HTR2B(1), HTR6(1), LEPR(1), MCHR1(1), NMUR2(2), NPBWR1(1), NPFFR2(1), NPY2R(1), NR3C1(2), NTSR1(1), P2RX1(1), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY6(2), PARD3(1), PRLR(1), PRSS3(1), PTGDR(1), PTGFR(2), PTGIR(1), RXFP2(2), SSTR1(2), SSTR3(1), SSTR4(2), TAAR9(1), TACR2(1), TRPV1(1), UTS2R(2), VIPR2(1) 53710533 112 78 111 38 18 16 26 43 9 0 0.446 1.000 1.000 521 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(3), ABLIM1(1), ABLIM2(1), ARHGEF12(3), CFL2(1), DCC(2), DPYSL2(1), EFNA1(2), EFNB2(1), EPHA2(1), EPHA3(1), EPHA4(1), EPHA6(2), EPHA7(1), EPHA8(2), EPHB1(2), EPHB4(2), EPHB6(2), FES(1), GNAI2(1), GNAI3(1), ITGB1(2), KRAS(2), LIMK1(2), LIMK2(2), LRRC4C(2), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NRAS(1), NTNG1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(1), PLXNA2(7), PLXNA3(2), PLXNB1(4), PLXNB2(3), PLXNB3(2), PPP3CA(1), PTK2(1), RAC2(1), RASA1(2), RGS3(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK2(1), SEMA3A(2), SEMA3D(1), SEMA3E(1), SEMA3F(1), SEMA4D(1), SEMA4F(1), SEMA4G(1), SEMA5A(1), SEMA5B(1), SEMA6B(1), SEMA7A(1), SLIT3(2), SRGAP1(5), SRGAP3(1), UNC5A(2), UNC5B(1), UNC5C(1) 47356802 113 77 112 30 13 14 11 54 21 0 0.375 1.000 1.000 522 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CADM3(2), CD40(1), CD58(1), CD6(1), CD86(2), CDH15(1), CDH4(1), CDH5(1), CLDN11(1), CLDN16(1), CLDN18(1), CNTN1(3), CNTNAP1(2), CTLA4(2), ESAM(2), GLG1(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(1), ITGA6(2), ITGA8(2), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), ITGB7(1), MADCAM1(1), MPZL1(1), NCAM1(2), NCAM2(4), NEO1(3), NFASC(3), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(1), PDCD1(1), PTPRC(2), PTPRF(3), PTPRM(4), PVRL1(1), PVRL2(1), PVRL3(2), SDC2(1), SDC4(1), SELE(1), SELL(1), VCAM1(2), VCAN(9) 35864466 97 74 97 39 10 6 13 46 22 0 0.928 1.000 1.000 523 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(1), AKT1(1), AKT2(2), AKT3(1), AMOTL1(3), ASH1L(3), CASK(1), CGN(2), CLDN11(1), CLDN16(1), CLDN18(1), CSNK2A1(2), CTNNA1(3), CTNNA2(1), CTNNA3(1), EPB41L1(3), EPB41L3(3), EXOC4(1), GNAI2(1), GNAI3(1), INADL(5), KRAS(2), MAGI1(1), MAGI2(2), MLLT4(3), MYH10(1), MYH11(2), MYH13(2), MYH14(1), MYH15(2), MYH3(1), MYH4(4), MYH6(2), MYH7(4), MYH7B(1), MYH8(1), MYH9(2), NRAS(1), PARD3(1), PARD6B(4), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PTEN(5), RAB13(1), RAB3B(1), SPTAN1(4), SRC(1), TJAP1(3), TJP1(3), TJP2(1), YES1(1) 46881368 112 74 110 40 7 11 24 41 29 0 0.926 1.000 1.000 524 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ARRB1(2), ATF3(1), ATP2A2(1), CAMK2A(1), CREB3(1), DGKZ(2), GABPA(1), GBA2(1), GNB1(1), GNG12(1), GRK4(1), GRK5(1), IGFBP1(1), IGFBP4(1), IGFBP6(2), ITPR1(2), ITPR2(3), ITPR3(1), MIB1(1), NFKB1(1), NOS1(1), NOS3(1), PKIB(1), PLCB3(1), PLCD1(2), PLCG1(1), PLCG2(2), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS16(1), RGS20(1), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(7), RYR2(6), RYR3(5), SFN(1), SLC8A1(2), TNXB(5), USP5(2) 42394971 94 74 94 28 12 16 11 34 21 0 0.356 1.000 1.000 525 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ADK(1), ADSL(2), ADSSL1(1), AK7(2), AMPD2(2), DCK(1), ENPP1(4), ENPP3(1), ENTPD1(1), ENTPD5(1), ENTPD6(2), GART(2), GMPS(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), NME7(1), NPR2(1), NT5C1B(1), NUDT5(1), PAPSS2(2), PDE11A(2), PDE1C(1), PDE2A(2), PDE3B(2), PDE4A(1), PDE5A(4), PDE7B(1), PDE9A(2), PFAS(1), PNPT1(2), POLA1(3), POLD1(1), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2), PPAT(1), PRIM1(1), PRIM2(3), PRPS2(1), PRUNE(1), RFC5(2) 39777822 93 71 93 26 8 15 9 43 18 0 0.483 1.000 1.000 526 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(1), BCAR1(1), CAPN1(1), CAPN11(1), CAPN2(2), CAPN3(1), CAPN5(2), CAPN7(3), CAPN9(1), CAV2(1), DOCK1(2), GIT2(1), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGAD(2), ITGAE(1), ITGAL(2), ITGAM(3), ITGAX(4), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK6(1), MAPK7(3), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PIK3R2(1), PTK2(1), PXN(1), RAC2(1), RAPGEF1(1), ROCK2(1), SEPP1(2), SORBS1(2), SOS1(3), SRC(1), TLN1(7), TNS1(2) 32890666 89 70 88 24 6 14 12 40 17 0 0.337 1.000 1.000 527 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), EGF(1), GNA11(1), GNAI2(1), GNAI3(1), GNAS(1), GRM5(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), HTR2B(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), MAP2K5(2), MAPK7(3), NPR2(1), NRAS(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKG1(1), PRKG2(1), PRKX(1), RAF1(2), SOS1(3), SOS2(1), SRC(1), TJP1(3), TUBA4A(1), TUBB(1), TUBB1(1) 32161619 73 57 71 28 8 15 3 34 13 0 0.789 1.000 1.000 528 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACTG1(1), BAIAP2(1), CREBBP(4), CSNK2A1(2), CTNNA1(3), CTNNA2(1), CTNNA3(1), EP300(5), ERBB2(3), FARP2(1), FGFR1(1), IGF1R(1), IQGAP1(1), LEF1(1), LMO7(1), MAP3K7(1), MLLT4(3), NLK(1), PARD3(1), PTPN1(1), PTPRB(2), PTPRF(3), PTPRJ(5), PTPRM(4), PVRL1(1), PVRL2(1), PVRL3(2), RAC2(1), SMAD4(2), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7L1(1), TGFBR1(1), TGFBR2(1), TJP1(3), WASF1(1), YES1(1) 28220964 69 55 69 28 4 11 9 25 19 1 0.949 1.000 1.000 529 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), CACNA1C(5), CACNA1D(2), CACNA1S(5), CAMK2A(1), GNA11(1), GNAS(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), MAP2K3(1), MAP3K1(2), MAP3K4(1), MAPK10(1), MAPK7(3), NRAS(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCD(2), PRKX(1), RAF1(2), SOS1(3), SOS2(1), SRC(1) 31229289 67 54 65 30 7 17 4 24 15 0 0.914 1.000 1.000 530 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTR2(1), AKT1(1), AKT2(2), AKT3(1), ARHGEF6(2), BCAR1(1), BRAF(2), CDKN2A(2), CSE1L(2), DOCK1(2), GRB7(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB3BP(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), P4HB(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CB(1), PLCG1(1), PLCG2(2), PTEN(5), PTK2(1), RAF1(2), ROCK2(1), SOS1(3), SOS2(1), SRC(1), TLN1(7), TLN2(3) 29834825 73 54 73 22 3 10 13 33 14 0 0.589 1.000 1.000 531 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA2A(2), ADORA3(1), AGTR2(1), AVPR2(1), C3AR1(2), CCBP2(1), CCKAR(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CCR7(1), CCRL1(1), CCRL2(1), CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), F2R(1), F2RL2(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(1), GPR50(1), GPR83(1), GPR85(1), GPR87(1), GRPR(1), HCRTR2(4), HRH3(1), HTR1B(1), HTR2B(1), HTR6(1), NMUR2(2), NPY2R(1), NTSR1(1), OR11A1(1), OR1F1(1), OR5V1(1), P2RY1(2), P2RY2(1), P2RY6(2), PTGDR(1), PTGFR(2), PTGIR(1), SSTR1(2), SSTR3(1), SSTR4(2), SUCNR1(1) 29328947 70 53 70 21 8 8 10 34 10 0 0.396 1.000 1.000 532 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(3), ANAPC10(1), ANAPC4(1), ANAPC5(2), ATM(1), ATR(3), BUB1(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CDC14B(1), CDC16(1), CDC20(2), CDC6(1), CDC7(1), CDKN2A(2), CHEK1(1), CREBBP(4), CUL1(2), E2F2(1), E2F3(1), EP300(5), ESPL1(3), GADD45B(1), MAD1L1(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), PKMYT1(1), PLK1(1), PRKDC(2), RBL2(2), SFN(1), SMAD4(2), SMC1A(2), SMC1B(2), TP53(4) 32631388 66 53 66 22 5 8 11 27 15 0 0.714 1.000 1.000 533 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(5), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(2), ABCA7(4), ABCA8(2), ABCB10(1), ABCB11(1), ABCB4(3), ABCB5(1), ABCB6(2), ABCB9(2), ABCC1(2), ABCC10(2), ABCC11(2), ABCC12(1), ABCC2(3), ABCC4(2), ABCC5(3), ABCC9(1), ABCD2(1), ABCD4(1), ABCG2(2), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3), TAP1(1) 28819866 67 52 67 23 6 9 12 33 7 0 0.640 1.000 1.000 534 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ASIP(1), CAMK2A(1), CREB3(1), CREB3L3(1), CREBBP(4), EP300(5), FZD1(2), FZD10(1), FZD4(1), FZD5(1), FZD7(1), GNAI2(1), GNAI3(1), GNAS(1), KRAS(2), LEF1(1), MAP2K2(1), MITF(3), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), POMC(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKX(1), RAF1(2), TCF7L1(1), TYRP1(2), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1) 26554216 67 51 66 22 6 13 7 25 16 0 0.622 1.000 1.000 535 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ARHGAP5(2), BCAR1(1), CDH5(1), CLDN11(1), CLDN16(1), CLDN18(1), CTNNA1(3), CTNNA2(1), CTNNA3(1), ESAM(2), EZR(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), MLLT4(3), MSN(1), NOX1(1), NOX3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PRKCG(3), PTK2(1), PTPN11(1), PXN(1), RAC2(1), RAPGEF3(1), RAPGEF4(1), ROCK2(1), SIPA1(1), TXK(1), VAV1(1), VCAM1(2) 30333740 60 49 60 17 5 9 8 30 8 0 0.569 1.000 1.000 536 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY8(3), ARAF(1), BRAF(2), CACNA1C(5), CAMK2A(1), CREBBP(4), EP300(5), GRIA1(2), GRIN2A(2), GRIN2B(1), GRIN2D(1), GRM5(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(1), PLCB4(1), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PRKACA(1), PRKACG(1), PRKCG(3), PRKX(1), RAF1(2), RAPGEF3(1), RPS6KA1(1), RPS6KA3(2) 24414221 60 48 59 22 3 13 8 25 11 0 0.719 1.000 1.000 537 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), DES(1), DMD(3), MYBPC1(2), MYH3(1), MYH6(2), MYH7(4), MYH8(1), MYL1(1), MYOM1(1), NEB(9), TCAP(1), TMOD1(1), TPM4(1), TTN(26), VIM(1) 33187110 56 47 55 19 5 9 6 25 11 0 0.728 1.000 1.000 538 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(1), AKAP11(1), AKAP12(2), AKAP3(2), AKAP5(1), AKAP6(1), AKAP9(2), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(1), GNB1(1), GNG12(1), ITPR1(2), KCNJ3(1), KRAS(2), NRAS(1), PALM2(1), PDE1C(1), PDE4A(1), PDE7B(1), PLCB3(1), PPP3CA(1), PRKACA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PRKD1(1), USP5(2) 28359282 60 45 59 22 3 14 5 22 16 0 0.780 1.000 1.000 539 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(1), AKT2(2), AKT3(1), APAF1(1), ATM(1), BAD(1), BID(1), BIRC3(1), CAPN1(1), CAPN2(2), CASP10(1), CASP9(1), CSF2RB(1), FASLG(2), IKBKB(1), IL1R1(1), MAP3K14(1), NFKB1(1), NFKB2(2), NFKBIA(2), NTRK1(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PPP3CA(1), PRKACA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RELA(1), TNF(1), TNFSF10(3), TP53(4) 20378790 51 43 51 20 4 6 8 22 11 0 0.889 1.000 1.000 540 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(1), AKT2(2), AKT3(1), BAD(1), CDKN2A(2), CREB3(1), ERBB4(3), F2RL2(1), GAB1(1), GSK3A(1), IGFBP1(1), INPPL1(2), IRS1(1), IRS2(2), NOLC1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PARD3(1), PIK3CA(2), PIK3CD(1), PREX1(1), PTEN(5), PTK2(1), PTPN1(1), RPS6KA1(1), RPS6KA3(2), SFN(1), SLC2A4(1), SOS1(3), SOS2(1), TSC1(2), TSC2(4) 18022048 54 43 54 17 6 10 15 11 12 0 0.302 1.000 1.000 541 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(1), BUB1(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CDAN1(2), CDC14B(1), CDC20(2), CDC6(1), CDC7(1), CDKN2A(2), CHEK1(1), DTX4(1), E2F2(1), E2F3(1), EP300(5), ESPL1(3), HDAC5(3), HDAC6(1), HDAC8(1), MAD1L1(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), MPEG1(1), PLK1(1), PRKDC(2), PTPRA(1), SMAD4(2), TP53(4) 26807069 53 41 53 17 5 7 7 23 11 0 0.646 1.000 1.000 542 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(4), DCK(1), DPYD(1), DPYS(2), ENTPD1(1), ENTPD5(1), ENTPD6(2), NME7(1), NT5C1B(1), PNPT1(2), POLA1(3), POLD1(1), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2), PRIM1(1), PRIM2(3), RFC5(2), TK2(1), TXNRD1(2), TYMS(1), UPRT(1) 19758467 45 40 45 15 4 4 5 19 13 0 0.849 1.000 1.000 543 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(2), AKT3(1), FCER1G(1), GAB2(1), KRAS(2), LAT(1), LCP2(2), LYN(1), MAP2K2(1), MAP2K3(1), MAPK10(1), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCG1(1), PLCG2(2), PRKCD(2), PRKCE(2), RAC2(1), RAF1(2), SOS1(3), SOS2(1), TNF(1), VAV1(1) 17462760 44 39 43 14 2 10 4 20 8 0 0.599 1.000 1.000 544 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(2), AKT3(1), CAP1(2), CBL(1), CDKN2A(2), F2RL2(1), GSK3A(1), IGFBP1(1), INPPL1(2), IRS1(1), IRS2(2), LNPEP(1), PARD3(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), PTEN(5), PTPN1(1), RAF1(2), RPS6KA1(1), RPS6KA3(2), SFN(1), SLC2A4(1), SORBS1(2), SOS1(3), SOS2(1) 14376745 43 37 43 18 3 8 9 12 11 0 0.875 1.000 1.000 545 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BAD(1), CABIN1(3), CREBBP(4), CSNK2A1(2), CTLA4(2), EP300(5), GSK3A(1), ICOS(1), JUNB(1), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB2(2), NUP214(4), P2RX7(1), PAK1(1), PPIA(1), PTPRC(2), RELA(1), SFN(1), TNF(1), TRPV6(1), VAV1(1) 21928364 43 36 43 14 4 3 8 15 13 0 0.784 1.000 1.000 546 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(2), AKT3(1), CARD11(2), CD81(1), CR2(1), IFITM1(1), IKBKB(1), KRAS(2), LYN(1), MALT1(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG2(2), PPP3CA(1), RAC2(1), RASGRP3(1), VAV1(1) 18092723 41 36 40 13 4 5 4 21 7 0 0.690 1.000 1.000 547 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(2), AKT3(1), CD40(1), CD86(2), IFNA16(1), IFNA2(1), IFNAR1(1), IKBKB(1), IKBKE(1), IRF5(1), MAP2K2(1), MAP2K3(1), MAP3K7(1), MAP3K8(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), RELA(1), STAT1(1), TLR1(1), TLR3(1), TLR4(1), TLR5(2), TLR6(1), TLR7(1), TNF(1) 21710298 42 35 42 15 3 5 6 19 8 1 0.805 1.000 1.000 548 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(1), ACSL1(2), ACSL6(1), AKT1(1), AKT2(2), AKT3(1), CAMKK1(2), CD36(1), IKBKB(1), IRS1(1), IRS2(2), JAK1(2), JAK2(1), JAK3(1), LEPR(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), PCK1(1), PCK2(1), POMC(1), PPARGC1A(1), PRKAG2(2), PRKCQ(1), PTPN11(1), RELA(1), SLC2A1(1), SLC2A4(1), STK11(2), TNF(1), TNFRSF1B(1) 20225618 41 35 41 14 6 6 6 17 6 0 0.600 1.000 1.000 549 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM17(2), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), CXCL1(1), GIT1(1), IKBKB(1), LYN(1), MAP3K14(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), NOD1(2), PAK1(1), PLCG1(1), PLCG2(2), PTPN11(1), PTPRZ1(4), RELA(1), SRC(1), TCIRG1(2), TJP1(3) 16387167 36 35 36 17 3 4 3 22 4 0 0.965 1.000 1.000 550 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(1), BIRC3(1), BIRC5(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1), FASLG(2), HELLS(2), IKBKB(1), IRF2(1), IRF5(1), IRF6(1), MAP3K1(2), MAPK10(1), NFKB1(1), NFKBIA(2), PLEKHG5(1), RELA(1), TNF(1), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TP53(4) 13965315 40 34 40 14 4 7 7 14 8 0 0.734 1.000 1.000 551 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(2), AKT3(1), BRAF(2), EIF4B(2), EIF4EBP1(1), HIF1A(1), INS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), RHEB(1), RICTOR(3), RPS6KA1(1), RPS6KA3(2), STK11(2), TSC1(2), TSC2(4), ULK1(1), ULK2(1) 12971411 37 34 37 12 4 10 7 10 5 1 0.460 1.000 1.000 552 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(2), CREBBP(4), CTBP1(1), DTX1(1), DTX3L(1), DTX4(1), EP300(5), JAG1(3), JAG2(1), MAML1(4), MAML2(4), MAML3(3), NCSTN(1), NOTCH1(5), NOTCH2(3), NOTCH3(2), NUMB(1), PTCRA(1), RBPJL(1) 17116558 44 34 43 37 1 10 4 15 13 1 1.000 1.000 1.000 553 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(2), CEBPA(1), DAXX(1), IKBKB(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K14(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K8(1), MAP3K9(1), MAP4K1(2), MAP4K3(2), MAPK10(1), MAPK6(1), MAPK7(3), NFKB1(1), NFKBIA(2), PAK1(1), RAF1(2), RELA(1), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), STAT1(1), TGFBR1(1) 23459528 40 34 39 21 2 5 6 17 9 1 0.992 1.000 1.000 554 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY6(1), ADCY8(3), CACNA1A(5), GNAS(1), GNB1(1), GRM4(3), ITPR3(1), PLCB2(2), PRKACA(1), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(2), TAS1R1(1), TAS1R2(4), TAS2R13(1), TAS2R14(1), TAS2R39(1), TAS2R41(1), TAS2R43(1), TRPM5(1) 13938682 34 33 34 14 12 5 2 7 8 0 0.683 1.000 1.000 555 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(2), CHRM2(2), CHRM3(1), CIDEB(1), DRD4(2), EMR2(1), F2R(1), GPR116(1), GPR133(3), GPR135(2), GPR18(2), GPR55(1), GRPR(1), LPHN2(1), NTSR1(1), PTGFR(2) 16132772 38 32 37 17 5 5 5 19 4 0 0.901 1.000 1.000 556 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP7(1), BMP8A(1), CSNK1E(3), FBXW11(1), GLI1(3), GLI3(2), IHH(1), LRP2(6), PRKACA(1), PRKACG(1), PRKX(1), PTCH1(1), SHH(1), SUFU(2), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1), ZIC2(1) 14688580 32 30 32 12 4 8 4 8 8 0 0.769 1.000 1.000 557 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CD36(1), CITED2(1), CREBBP(4), EHHADH(1), EP300(5), HSD17B4(1), INS(1), LPL(1), MRPL11(1), NCOA1(1), NCOR1(3), NFKBIA(2), NR2F1(1), PIK3CA(2), PIK3R1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RELA(1), STAT5A(1), TNF(1) 15348533 35 30 35 23 1 6 2 13 13 0 0.999 1.000 1.000 558 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(1), AKT2(2), AKT3(1), CFL2(1), INPPL1(2), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PTEN(5), ROCK2(1), WASF1(1) 17044755 34 30 34 12 4 8 4 12 6 0 0.740 1.000 1.000 559 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BAK1(1), BFAR(1), CAD(4), CASP10(1), CASP8AP2(3), DAXX(1), DEDD(1), DIABLO(1), MAP3K1(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), RALBP1(1), SMPD1(3), TP53(4), TPX2(1) 17163565 34 30 34 17 6 5 2 14 7 0 0.956 1.000 1.000 560 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(3), AKT1(1), CALR(1), CAMK1(2), CREBBP(4), F2(1), HAND2(1), NFATC2(3), NFATC3(2), NKX2-5(3), PIK3CA(2), PIK3R1(2), PPP3CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RAF1(2) 12246765 32 29 32 16 3 6 2 12 9 0 0.977 1.000 1.000 561 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), BRAF(2), CAMP(1), CREB3(1), CREBBP(4), CRKL(1), DAG1(3), MAP1B(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NTRK1(2), PIK3C2G(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), PTPN11(1), RPS6KA3(2), SRC(1) 12590470 32 28 32 14 3 7 7 9 6 0 0.814 1.000 1.000 562 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), ERBB2(3), ERBB4(3), ETS1(1), FMN2(1), KRAS(2), NOTCH1(5), NOTCH2(3), NOTCH3(2), PIWIL4(1), RAF1(2), SOS1(3), SOS2(1), SPIRE2(1) 12751383 30 27 29 13 2 7 4 8 9 0 0.864 1.000 1.000 563 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(3), ACOX1(1), ACOX2(1), ACOX3(3), ACSL1(2), ACSL6(1), AQP7(1), CD36(1), CYP4A11(1), CYP4A22(1), EHHADH(1), LPL(1), PCK1(1), PCK2(1), SCP2(1), SLC27A1(2), SLC27A6(1), SORBS1(2) 15827210 28 26 28 13 2 6 1 12 6 1 0.940 1.000 1.000 564 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), DLD(2), GAB1(1), GCK(2), IL1R1(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K4(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK7(3), MYEF2(1), NFATC3(2), PAPPA(3), TP53(4) 12192773 29 26 28 13 0 4 3 16 4 2 0.928 1.000 1.000 565 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), BID(1), BIRC3(1), CASP9(1), DAXX(1), GSN(2), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(2), NUMA1(3), PRKCD(2), PRKDC(2), PTK2(1), RASA1(2), RELA(1), SPTAN1(4), TNF(1), TNFRSF1B(1) 16904972 31 25 31 14 1 6 3 8 13 0 0.965 1.000 1.000 566 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAK1(1), BID(1), BIRC3(1), CASP9(1), FASLG(2), MAP3K1(2), MAP3K14(1), MAPK10(1), NFKB1(1), NFKBIA(2), PARP1(2), RELA(1), TNF(1), TNFRSF1B(1), TNFSF10(3), TP53(4) 9071357 26 24 26 12 2 5 4 9 6 0 0.920 1.000 1.000 567 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(1), CDS2(1), CHPT1(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), ETNK2(1), GPAM(2), GPD1(1), GPD1L(1), LCAT(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PNPLA3(1) 16043359 26 24 26 12 1 4 2 12 7 0 0.890 1.000 1.000 568 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CANX(1), CIITA(2), CTSB(1), CTSL1(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(1), IFNA16(1), IFNA2(1), KIR2DL4(1), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC2(1), KLRC3(1), NFYA(1), PSME2(2), RFX5(1), TAP1(1) 11230460 28 24 28 13 2 5 2 8 10 1 0.901 1.000 1.000 569 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 LAT(1), MAP3K1(2), NFATC2(3), NFATC3(2), NFKB1(1), NFKBIA(2), PIK3CA(2), PIK3R1(2), PLCG1(1), PPP3CA(1), RAF1(2), RASA1(2), RELA(1), SOS1(3), VAV1(1), ZAP70(1) 11556184 27 24 27 10 2 5 0 10 10 0 0.909 1.000 1.000 570 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CREBBP(4), EP300(5), ERCC3(3), GRIP1(2), GTF2A1(1), HDAC5(3), HDAC6(1), POLR2A(3) 11349198 24 23 24 20 3 3 2 9 7 0 1.000 1.000 1.000 571 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(1), DAXX(1), EGF(1), ETS1(1), HOXA7(1), IKBKB(1), MAP2K3(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(2), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), RAF1(2), RELA(1), TNF(1), TNFRSF1B(1) 11852566 26 23 26 11 2 4 0 11 9 0 0.966 1.000 1.000 572 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(1), CHRM1(2), CHRNA1(1), FLT1(1), FLT4(3), KDR(1), NOS3(1), PDE2A(2), PDE3B(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(6), SLC7A1(1) 9974508 27 23 27 11 2 5 2 14 4 0 0.785 1.000 1.000 573 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(3), EIF1AX(1), EIF2AK1(3), EIF2S3(1), EIF4A1(1), EIF4A2(1), EIF4EBP1(1), EIF4G1(1), EIF4G3(4), EIF5B(1), GSPT2(1), PABPC1(1), PABPC3(1) 10676948 28 23 28 11 1 6 2 12 6 1 0.844 1.000 1.000 574 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(2), COX10(3), COX15(1), CP(3), EPRS(2), FTMT(1), HMOX1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1), UROD(1) 10162867 22 22 22 12 2 1 4 12 3 0 0.974 1.000 1.000 575 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(1), DLD(2), GAPDH(2), GAPDHS(2), GCK(2), HK1(1), LDHB(1), MDH1(1), PC(5), PCK1(1), PDHX(1), PFKL(1), PFKP(1), PGAM2(1), PGK2(1), TPI1(1) 10258603 24 21 24 10 0 1 4 7 11 1 0.941 1.000 1.000 576 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(2), AKT3(1), DLG4(1), LPA(3), MAP3K1(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PTK2(1), RDX(1), ROCK2(1) 11881709 23 21 23 14 5 4 4 8 2 0 0.956 1.000 1.000 577 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 ERCC3(3), GTF2B(2), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3B(2), TAF6(1), TAF7(1) 8514400 20 20 20 10 3 1 2 10 4 0 0.945 1.000 1.000 578 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAD(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1), CD40(1), DAXX(1), FASLG(2), IKBKE(1), NFKB1(1), NFKBIA(2), NR3C1(2), NTRK1(2), TNF(1), TNFRSF1B(1) 10586289 20 18 20 11 2 4 4 6 4 0 0.957 1.000 1.000 579 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR2(1), AKT1(1), CFL2(1), FLNA(1), FLNC(4), FSCN1(1), LIMK1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), WASF1(1) 11675079 19 18 19 12 3 5 1 7 3 0 0.966 1.000 1.000 580 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(1), GAA(1), GALE(1), GCK(2), HK1(1), LCT(3), MGAM(3), PFKL(1), PFKP(1), PGM1(1), RDH11(1), RDH13(1) 9419138 17 16 17 10 3 1 0 9 4 0 0.988 1.000 1.000 581 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2S3(1), FLT1(1), FLT4(3), HIF1A(1), KDR(1), NOS3(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PTK2(1), PXN(1), VHL(2) 8304437 17 16 17 10 2 3 2 4 5 1 0.982 1.000 1.000 582 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), TRAF5(2) 8277851 17 15 17 10 3 3 2 5 4 0 0.968 1.000 1.000 583 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 MAP3K1(2), NFATC2(3), NFKB1(1), NFKBIA(2), PLCG1(1), PPP3CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIPR2(1) 6740139 15 15 15 10 2 1 0 5 7 0 0.997 1.000 1.000 584 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(5), NCOA3(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5007443 14 14 14 10 0 2 1 4 7 0 0.994 1.000 1.000 585 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 AKT1(1), CAMK2A(1), GNAS(1), PIK3CA(2), PIK3R1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SOS1(3) 7088184 14 14 14 10 1 3 1 4 5 0 0.982 1.000 1.000 586 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), DAXX(1), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(2), RIPK2(2), SPTAN1(4) 10034649 14 14 14 11 1 1 1 4 6 1 0.999 1.000 1.000 587 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), EZR(1), ITGB1(2), KRT18(1), NCK2(1), ROCK2(1), TLR4(1), TLR5(2), TUBA4A(1), TUBB(1), TUBB1(1) 12457157 16 14 16 12 2 1 4 6 3 0 0.991 1.000 1.000 588 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), EZR(1), ITGB1(2), KRT18(1), NCK2(1), ROCK2(1), TLR4(1), TLR5(2), TUBA4A(1), TUBB(1), TUBB1(1) 12457157 16 14 16 12 2 1 4 6 3 0 0.991 1.000 1.000 589 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 MADD(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(2), SPTAN1(4), TNF(1) 9504571 14 14 14 11 0 1 2 5 5 1 0.999 1.000 1.000 590 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(1), AXIN1(2), FZD1(2), LEF1(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RELA(1), TLR4(1) 7437366 14 13 14 10 1 2 1 8 2 0 0.993 1.000 1.000 591 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(1), GTF2B(2), NCOA1(1), NCOA2(2), NCOA3(2), POLR2A(3) 6100881 14 13 14 13 3 1 1 7 2 0 0.997 1.000 1.000 592 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 AKT1(1), BAD(1), CSF2RB(1), IGF1R(1), PIK3CA(2), PIK3R1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5299040 11 11 11 11 0 2 1 5 3 0 0.999 1.000 1.000 593 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), HTR1B(1), HTR2B(1), HTR6(1) 6237696 12 10 12 7 2 2 0 8 0 0 0.875 1.000 1.000 594 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(2), GRIN2B(1), GRIN2D(1), NOS1(1), PPP3CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 6245446 10 10 10 10 1 1 3 2 3 0 0.997 1.000 1.000 595 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(1), MAP3K1(2), MAP3K7(1), MAP3K9(1), PLA2G4A(1), STAT1(1), TGFBR1(1) 8929280 8 8 8 10 0 1 0 4 2 1 1.000 1.000 1.000 596 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GPHN(3), SRC(1) 2886800 6 5 6 5 2 0 0 4 0 0 0.962 1.000 1.000 597 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), SHH(1), XPO1(2) 2100921 4 4 4 3 1 1 2 0 0 0 0.840 1.000 1.000 598 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ARPC2(1), WASF1(1) 1971981 4 4 4 4 0 2 0 2 0 0 0.976 1.000 1.000 599 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK4(1), EIF2S3(1), PPP1CA(1) 2785218 3 3 3 4 1 0 1 1 0 0 0.982 1.000 1.000 600 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GPX1(1), PRKCE(2) 1807032 3 3 3 3 0 1 0 2 0 0 0.965 1.000 1.000 601 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 HK1(1), PFKL(1), TPI1(1) 2242801 3 3 3 4 0 1 1 1 0 0 0.951 1.000 1.000 602 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(1), GNB1(1), PRKACA(1) 1611682 3 3 3 2 1 0 1 1 0 0 0.908 1.000 1.000 603 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(1), ADH6(1) 1351854 2 2 2 2 0 0 0 2 0 0 0.968 1.000 1.000 604 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(1), RDH13(1) 1161009 2 2 2 2 0 0 0 2 0 0 0.953 1.000 1.000 605 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(1), PLCG1(1) 3321693 2 1 2 4 0 0 0 2 0 0 0.997 1.000 1.000 606 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1) 2297103 1 1 1 7 0 0 0 1 0 0 1.000 1.000 1.000 607 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 958254 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 574789 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 635606 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 174446 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 367212 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 483874 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 1133971 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 409103 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 929316 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 277652 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000