Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	132.0	4512.0	34.0	-0.626	0.012	1000.0	-1000.0	-0.055	-1000.0
EGFR-dependent Endothelin signaling events	114.0	2399.0	21.0	-0.732	0.018	1000.0	-1000.0	-0.062	-1000.0
Angiopoietin receptor Tie2-mediated signaling	112.0	9878.0	88.0	-1.086	0.1	1000.0	-1000.0	-0.092	-1000.0
PDGFR-alpha signaling pathway	85.0	3749.0	44.0	-0.382	0.029	1000.0	-1000.0	-0.051	-1000.0
FOXA2 and FOXA3 transcription factor networks	60.0	2802.0	46.0	-1.124	0.019	1000.0	-1000.0	-0.076	-1000.0
Signaling mediated by p38-alpha and p38-beta	56.0	2507.0	44.0	-0.293	0.012	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	55.0	5830.0	105.0	-0.732	0.088	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	46.0	3603.0	78.0	-0.424	0.099	1000.0	-1000.0	-0.068	-1000.0
Arf6 signaling events	44.0	2761.0	62.0	-0.732	0.031	1000.0	-1000.0	-0.063	-1000.0
Endothelins	42.0	4122.0	96.0	-0.638	0.012	1000.0	-1000.0	-0.082	-1000.0
Glypican 1 network	39.0	1919.0	48.0	-0.432	0.03	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	35.0	3208.0	91.0	-0.916	0.57	1000.0	-1000.0	-0.128	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	35.0	4453.0	125.0	-0.179	0.032	1000.0	-1000.0	-0.093	-1000.0
BMP receptor signaling	34.0	2813.0	81.0	-0.55	0.018	1000.0	-1000.0	-0.094	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2263.0	68.0	-0.623	0.084	1000.0	-1000.0	-0.1	-1000.0
S1P1 pathway	32.0	1157.0	36.0	-0.274	0.012	1000.0	-1000.0	-0.052	-1000.0
amb2 Integrin signaling	30.0	2484.0	82.0	-0.472	0.012	1000.0	-1000.0	-0.072	-1000.0
TCGA08_retinoblastoma	29.0	233.0	8.0	-0.203	0.052	1000.0	-1000.0	-0.019	-1000.0
Syndecan-1-mediated signaling events	26.0	897.0	34.0	-0.138	0.012	1000.0	-1000.0	-0.046	-1000.0
Integrins in angiogenesis	23.0	1989.0	84.0	-0.523	0.033	1000.0	-1000.0	-0.087	-1000.0
Glypican 2 network	21.0	86.0	4.0	-0.1	-0.091	1000.0	-1000.0	-0.024	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	21.0	1582.0	74.0	-0.732	0.045	1000.0	-1000.0	-0.09	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2302.0	120.0	-0.354	0.129	1000.0	-1000.0	-0.069	-1000.0
Noncanonical Wnt signaling pathway	18.0	484.0	26.0	-0.159	0.012	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PTP1B	18.0	1369.0	76.0	-0.736	0.092	1000.0	-1000.0	-0.083	-1000.0
Aurora C signaling	18.0	132.0	7.0	-0.109	0.012	1000.0	-1000.0	-0.03	-1000.0
Syndecan-4-mediated signaling events	18.0	1246.0	67.0	-0.422	0.072	1000.0	-1000.0	-0.09	-1000.0
Signaling events regulated by Ret tyrosine kinase	17.0	1454.0	82.0	-0.144	0.012	1000.0	-1000.0	-0.078	-1000.0
Wnt signaling	17.0	121.0	7.0	-0.083	0.012	1000.0	-1000.0	-0.023	-1000.0
Plasma membrane estrogen receptor signaling	17.0	1534.0	86.0	-0.224	0.023	1000.0	-1000.0	-0.079	-1000.0
LPA4-mediated signaling events	16.0	195.0	12.0	-0.251	0.018	1000.0	-1000.0	-0.025	-1000.0
Glucocorticoid receptor regulatory network	16.0	1848.0	114.0	-0.718	0.198	1000.0	-1000.0	-0.067	-1000.0
TCR signaling in naïve CD8+ T cells	16.0	1536.0	93.0	-0.564	0.265	1000.0	-1000.0	-0.079	-1000.0
IL6-mediated signaling events	16.0	1242.0	75.0	-0.226	0.052	1000.0	-1000.0	-0.074	-1000.0
E-cadherin signaling events	16.0	81.0	5.0	-0.064	0.012	1000.0	-1000.0	-0.047	-1000.0
Ephrin A  reverse signaling	15.0	110.0	7.0	-0.051	-0.0	1000.0	-1000.0	-0.033	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	489.0	31.0	-0.199	0.013	1000.0	-1000.0	-0.071	-1000.0
Coregulation of Androgen receptor activity	14.0	1095.0	76.0	-0.756	0.022	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by the Hedgehog family	14.0	769.0	52.0	-0.08	0.031	1000.0	-1000.0	-0.049	-1000.0
HIF-1-alpha transcription factor network	14.0	1089.0	76.0	-0.2	0.046	1000.0	-1000.0	-0.107	-1000.0
Ceramide signaling pathway	14.0	1095.0	76.0	-0.732	0.251	1000.0	-1000.0	-0.06	-1000.0
p75(NTR)-mediated signaling	13.0	1651.0	125.0	-0.429	0.032	1000.0	-1000.0	-0.089	-1000.0
FoxO family signaling	13.0	879.0	64.0	-0.774	0.091	1000.0	-1000.0	-0.06	-1000.0
IL27-mediated signaling events	13.0	701.0	51.0	-1.051	0.175	1000.0	-1000.0	-0.074	-1000.0
Visual signal transduction: Rods	13.0	697.0	52.0	-0.278	0.012	1000.0	-1000.0	-0.077	-1000.0
FOXM1 transcription factor network	13.0	691.0	51.0	-0.197	0.028	1000.0	-1000.0	-0.166	-1000.0
S1P3 pathway	12.0	522.0	42.0	-0.203	0.018	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	11.0	684.0	61.0	-0.25	0.116	1000.0	-1000.0	-0.062	-1000.0
Reelin signaling pathway	11.0	631.0	56.0	-0.199	0.018	1000.0	-1000.0	-0.07	-1000.0
EPHB forward signaling	11.0	956.0	85.0	-0.198	0.068	1000.0	-1000.0	-0.086	-1000.0
Nongenotropic Androgen signaling	11.0	609.0	52.0	-0.078	0.019	1000.0	-1000.0	-0.064	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1383.0	136.0	-0.619	0.106	1000.0	-1000.0	-0.062	-1000.0
ErbB4 signaling events	10.0	720.0	69.0	-0.238	0.115	1000.0	-1000.0	-0.084	-1000.0
Osteopontin-mediated events	10.0	394.0	38.0	-0.104	0.029	1000.0	-1000.0	-0.096	-1000.0
Regulation of Androgen receptor activity	10.0	719.0	70.0	-0.87	0.027	1000.0	-1000.0	-0.062	-1000.0
Aurora B signaling	10.0	679.0	67.0	-0.313	0.012	1000.0	-1000.0	-0.063	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	271.0	28.0	-0.203	0.018	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	9.0	932.0	102.0	-0.732	0.043	1000.0	-1000.0	-0.105	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	314.0	33.0	-0.2	0.035	1000.0	-1000.0	-0.058	-1000.0
E-cadherin signaling in keratinocytes	9.0	400.0	43.0	-0.323	0.033	1000.0	-1000.0	-0.07	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	145.0	17.0	-0.045	0.02	1000.0	-1000.0	-0.065	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	688.0	85.0	-0.104	0.017	1000.0	-1000.0	-0.08	-1000.0
Effects of Botulinum toxin	8.0	212.0	26.0	-0.261	0.015	1000.0	-1000.0	-0.056	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	659.0	76.0	-0.064	0.027	1000.0	-1000.0	-0.085	-1000.0
IL1-mediated signaling events	7.0	443.0	62.0	-0.244	0.058	1000.0	-1000.0	-0.098	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	7.0	380.0	52.0	-0.269	0.057	1000.0	-1000.0	-0.066	-1000.0
Syndecan-3-mediated signaling events	7.0	274.0	35.0	-0.18	0.018	1000.0	-1000.0	-0.06	-1000.0
IL23-mediated signaling events	7.0	430.0	60.0	-0.203	0.02	1000.0	-1000.0	-0.168	-1000.0
Caspase cascade in apoptosis	6.0	510.0	74.0	-0.413	0.041	1000.0	-1000.0	-0.035	-1000.0
IL12-mediated signaling events	6.0	602.0	87.0	-0.149	0.038	1000.0	-1000.0	-0.117	-1000.0
BARD1 signaling events	6.0	389.0	57.0	-0.098	0.023	1000.0	-1000.0	-0.062	-1000.0
Syndecan-2-mediated signaling events	6.0	452.0	69.0	-0.472	0.039	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	6.0	301.0	48.0	-0.109	0.036	1000.0	-1000.0	-0.066	-1000.0
TCGA08_rtk_signaling	6.0	171.0	26.0	-0.377	0.025	1000.0	-1000.0	-0.019	-1000.0
BCR signaling pathway	6.0	666.0	99.0	-0.065	0.033	1000.0	-1000.0	-0.084	-1000.0
PDGFR-beta signaling pathway	6.0	677.0	97.0	-0.12	0.043	1000.0	-1000.0	-0.091	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.008	-1000.0	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	5.0	16.0	3.0	-0.002	0.011	1000.0	-1000.0	-0.018	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	290.0	54.0	-0.19	0.025	1000.0	-1000.0	-0.087	-1000.0
Canonical Wnt signaling pathway	5.0	263.0	51.0	-0.25	0.122	1000.0	-1000.0	-0.06	-1000.0
Regulation of p38-alpha and p38-beta	5.0	291.0	54.0	-0.212	0.063	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	5.0	315.0	57.0	-0.033	0.038	1000.0	-1000.0	-0.093	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	91.0	17.0	-0.004	0.027	1000.0	-1000.0	-0.037	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	394.0	97.0	-0.104	0.028	1000.0	-1000.0	-0.081	-1000.0
Nectin adhesion pathway	4.0	268.0	63.0	-0.064	0.044	1000.0	-1000.0	-0.072	-1000.0
S1P5 pathway	4.0	74.0	17.0	-0.044	0.025	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	4.0	215.0	47.0	-0.204	0.015	1000.0	-1000.0	-0.046	-1000.0
LPA receptor mediated events	4.0	440.0	102.0	-0.104	0.053	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by PRL	4.0	168.0	34.0	-0.032	0.021	1000.0	-1000.0	-0.038	-1000.0
S1P4 pathway	4.0	116.0	25.0	-0.044	0.027	1000.0	-1000.0	-0.047	-1000.0
ErbB2/ErbB3 signaling events	3.0	198.0	65.0	-0.087	0.034	1000.0	-1000.0	-0.062	-1000.0
Cellular roles of Anthrax toxin	3.0	147.0	39.0	-0.214	0.018	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	3.0	257.0	68.0	-0.281	0.069	1000.0	-1000.0	-0.097	-1000.0
HIF-2-alpha transcription factor network	3.0	135.0	43.0	-0.249	0.095	1000.0	-1000.0	-0.079	-1000.0
IL2 signaling events mediated by PI3K	3.0	214.0	58.0	-0.044	0.061	1000.0	-1000.0	-0.071	-1000.0
Class I PI3K signaling events	3.0	235.0	73.0	-0.045	0.037	1000.0	-1000.0	-0.066	-1000.0
Arf6 trafficking events	3.0	276.0	71.0	-0.34	0.04	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by HDAC Class II	2.0	215.0	75.0	-0.167	0.037	1000.0	-1000.0	-0.055	-1000.0
PLK1 signaling events	2.0	207.0	85.0	-0.067	0.025	1000.0	-1000.0	-0.047	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	185.0	83.0	-0.215	0.05	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	2.0	53.0	22.0	-0.026	0.052	1000.0	-1000.0	-0.048	-1000.0
Insulin Pathway	2.0	159.0	74.0	-0.05	0.033	1000.0	-1000.0	-0.085	-1000.0
VEGFR1 specific signals	2.0	123.0	56.0	-0.009	0.045	1000.0	-1000.0	-0.084	-1000.0
Visual signal transduction: Cones	1.0	46.0	38.0	-0.014	0.014	1000.0	-1000.0	-0.051	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	89.0	65.0	-0.044	0.061	1000.0	-1000.0	-0.059	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	54.0	37.0	-0.028	0.038	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by HDAC Class I	1.0	185.0	104.0	-0.167	0.052	1000.0	-1000.0	-0.057	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	25.0	15.0	-0.0	0.026	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	1.0	80.0	58.0	-0.076	0.033	1000.0	-1000.0	-0.071	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	52.0	45.0	-0.017	0.067	1000.0	-1000.0	-0.082	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	-0.002	0.044	1000.0	-1000.0	-0.055	-1000.0
Canonical NF-kappaB pathway	0.0	9.0	39.0	-0.009	0.076	1000.0	-1000.0	-0.077	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.013	0.044	1000.0	-1000.0	-0.056	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.012	0.018	1000.0	-1000.0	-0.016	-1000.0
Aurora A signaling	0.0	39.0	60.0	-0.068	0.036	1000.0	-1000.0	-0.048	-1000.0
Arf6 downstream pathway	0.0	0.0	43.0	-0.027	0.028	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	0.0	53.0	55.0	-0.032	0.074	1000.0	-1000.0	-0.094	-1000.0
Insulin-mediated glucose transport	0.0	10.0	32.0	-0.117	0.07	1000.0	-1000.0	-0.054	-1000.0
mTOR signaling pathway	0.0	45.0	53.0	-0.006	0.033	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	10.0	68.0	-0.117	0.047	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by HDAC Class III	0.0	22.0	40.0	-0.019	0.021	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	0.0	10.0	48.0	-0.003	0.043	1000.0	-1000.0	-0.059	-1000.0
ceramide signaling pathway	0.0	14.0	49.0	-0.012	0.048	1000.0	-1000.0	-0.042	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.133	0.084	1000.0	-1000.0	-0.013	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	4.0	36.0	-0.036	0.038	1000.0	-1000.0	-0.069	-1000.0
Atypical NF-kappaB pathway	0.0	29.0	31.0	-0.003	0.044	1000.0	-1000.0	-0.043	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.032	1000.0	-1000.0	-0.052	-1000.0
Rapid glucocorticoid signaling	0.0	15.0	20.0	-0.002	0.012	1000.0	-1000.0	-0.034	-1000.0
p38 MAPK signaling pathway	0.0	26.0	44.0	-0.059	0.034	1000.0	-1000.0	-0.06	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.005	0.03	1000.0	-1000.0	-0.047	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.018	1000.0	-1000.0	-0.056	-1000.0
Total	1831	110477	7203	-32.4999523836	-993.73247959	131000	-131000	-8.37708254045	-131000