Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	169.0	8830.0	52.0	-0.644	0.345	1000.0	-1000.0	-0.092	-1000.0
Angiopoietin receptor Tie2-mediated signaling	157.0	13822.0	88.0	-0.749	0.06	1000.0	-1000.0	-0.131	-1000.0
Aurora B signaling	125.0	8435.0	67.0	-0.625	0.005	1000.0	-1000.0	-0.085	-1000.0
FOXM1 transcription factor network	116.0	5936.0	51.0	-0.707	0.002	1000.0	-1000.0	-0.204	-1000.0
Endothelins	84.0	8133.0	96.0	-0.437	0.036	1000.0	-1000.0	-0.097	-1000.0
TCGA08_retinoblastoma	64.0	516.0	8.0	-0.278	0.087	1000.0	-1000.0	-0.031	-1000.0
Glypican 2 network	61.0	247.0	4.0	-0.085	-0.068	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	60.0	4946.0	82.0	-0.68	0.0	1000.0	-1000.0	-0.103	-1000.0
Thromboxane A2 receptor signaling	54.0	5731.0	105.0	-0.181	0.041	1000.0	-1000.0	-0.095	-1000.0
Fc-epsilon receptor I signaling in mast cells	53.0	5171.0	97.0	-0.258	0.033	1000.0	-1000.0	-0.115	-1000.0
Aurora C signaling	51.0	363.0	7.0	-0.412	0.0	1000.0	-1000.0	-0.051	-1000.0
IL4-mediated signaling events	49.0	4538.0	91.0	-0.806	0.45	1000.0	-1000.0	-0.196	-1000.0
Signaling events regulated by Ret tyrosine kinase	46.0	3777.0	82.0	-0.204	0.0	1000.0	-1000.0	-0.111	-1000.0
Glucocorticoid receptor regulatory network	45.0	5170.0	114.0	-0.56	0.361	1000.0	-1000.0	-0.093	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	43.0	2238.0	52.0	-0.382	0.057	1000.0	-1000.0	-0.083	-1000.0
PLK1 signaling events	42.0	3647.0	85.0	-0.38	0.072	1000.0	-1000.0	-0.062	-1000.0
Arf6 signaling events	40.0	2490.0	62.0	-0.302	0.015	1000.0	-1000.0	-0.072	-1000.0
BMP receptor signaling	40.0	3275.0	81.0	-0.387	0.037	1000.0	-1000.0	-0.106	-1000.0
Canonical Wnt signaling pathway	39.0	2002.0	51.0	-0.467	0.164	1000.0	-1000.0	-0.071	-1000.0
Visual signal transduction: Cones	38.0	1456.0	38.0	-0.288	0.009	1000.0	-1000.0	-0.081	-1000.0
Glypican 1 network	38.0	1863.0	48.0	-0.223	0.032	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	2973.0	78.0	-0.129	0.036	1000.0	-1000.0	-0.094	-1000.0
Presenilin action in Notch and Wnt signaling	35.0	2154.0	61.0	-0.467	0.016	1000.0	-1000.0	-0.087	-1000.0
Integrins in angiogenesis	35.0	2954.0	84.0	-0.461	0.031	1000.0	-1000.0	-0.107	-1000.0
Nongenotropic Androgen signaling	35.0	1857.0	52.0	-0.152	0.048	1000.0	-1000.0	-0.071	-1000.0
Nectin adhesion pathway	34.0	2164.0	63.0	-0.273	0.0	1000.0	-1000.0	-0.09	-1000.0
TCGA08_p53	34.0	242.0	7.0	-0.193	0.097	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	32.0	1007.0	31.0	-0.21	0.012	1000.0	-1000.0	-0.133	-1000.0
FOXA2 and FOXA3 transcription factor networks	30.0	1418.0	46.0	-0.768	0.072	1000.0	-1000.0	-0.117	-1000.0
HIF-1-alpha transcription factor network	29.0	2230.0	76.0	-0.442	0.017	1000.0	-1000.0	-0.222	-1000.0
Coregulation of Androgen receptor activity	27.0	2092.0	76.0	-0.396	0.031	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	27.0	1635.0	60.0	-0.241	0.018	1000.0	-1000.0	-0.192	-1000.0
LPA4-mediated signaling events	26.0	323.0	12.0	-0.141	0.017	1000.0	-1000.0	-0.037	-1000.0
Syndecan-3-mediated signaling events	26.0	938.0	35.0	-0.343	0.0	1000.0	-1000.0	-0.079	-1000.0
Reelin signaling pathway	25.0	1412.0	56.0	-0.13	0.003	1000.0	-1000.0	-0.122	-1000.0
IL6-mediated signaling events	25.0	1911.0	75.0	-0.477	0.05	1000.0	-1000.0	-0.117	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	25.0	1706.0	68.0	-0.227	0.015	1000.0	-1000.0	-0.153	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	23.0	2960.0	125.0	-0.202	0.0	1000.0	-1000.0	-0.123	-1000.0
ErbB4 signaling events	22.0	1583.0	69.0	-0.384	0.198	1000.0	-1000.0	-0.103	-1000.0
Aurora A signaling	22.0	1335.0	60.0	-0.489	0.028	1000.0	-1000.0	-0.075	-1000.0
Wnt signaling	22.0	155.0	7.0	-0.094	0.0	1000.0	-1000.0	-0.059	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	22.0	2668.0	120.0	-0.267	0.129	1000.0	-1000.0	-0.093	-1000.0
Regulation of Androgen receptor activity	22.0	1600.0	70.0	-0.417	0.018	1000.0	-1000.0	-0.082	-1000.0
Syndecan-1-mediated signaling events	21.0	725.0	34.0	-0.356	0.0	1000.0	-1000.0	-0.087	-1000.0
Signaling mediated by p38-alpha and p38-beta	21.0	957.0	44.0	-0.126	0.0	1000.0	-1000.0	-0.065	-1000.0
p75(NTR)-mediated signaling	20.0	2514.0	125.0	-0.345	0.0	1000.0	-1000.0	-0.128	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	686.0	33.0	-0.269	0.0	1000.0	-1000.0	-0.071	-1000.0
IL12-mediated signaling events	19.0	1704.0	87.0	-0.163	0.019	1000.0	-1000.0	-0.157	-1000.0
Osteopontin-mediated events	19.0	728.0	38.0	-0.289	0.0	1000.0	-1000.0	-0.13	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1705.0	86.0	-0.181	0.031	1000.0	-1000.0	-0.098	-1000.0
Visual signal transduction: Rods	19.0	999.0	52.0	-0.179	0.0	1000.0	-1000.0	-0.11	-1000.0
HIF-2-alpha transcription factor network	17.0	753.0	43.0	-0.375	0.206	1000.0	-1000.0	-0.119	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1599.0	93.0	-0.066	0.035	1000.0	-1000.0	-0.104	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	16.0	894.0	54.0	-0.15	0.02	1000.0	-1000.0	-0.121	-1000.0
PDGFR-alpha signaling pathway	16.0	716.0	44.0	-0.202	0.021	1000.0	-1000.0	-0.074	-1000.0
Ephrin A  reverse signaling	14.0	100.0	7.0	-0.024	0.002	1000.0	-1000.0	-0.041	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1273.0	85.0	-0.159	0.011	1000.0	-1000.0	-0.095	-1000.0
EGFR-dependent Endothelin signaling events	13.0	276.0	21.0	-0.065	0.0	1000.0	-1000.0	-0.08	-1000.0
Noncanonical Wnt signaling pathway	12.0	317.0	26.0	-0.103	0.0	1000.0	-1000.0	-0.098	-1000.0
Caspase cascade in apoptosis	11.0	849.0	74.0	-0.071	0.035	1000.0	-1000.0	-0.071	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1552.0	136.0	-0.335	0.094	1000.0	-1000.0	-0.108	-1000.0
Syndecan-2-mediated signaling events	11.0	770.0	69.0	-0.168	0.031	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class III	11.0	443.0	40.0	-0.147	0.05	1000.0	-1000.0	-0.056	-1000.0
FAS signaling pathway (CD95)	11.0	541.0	47.0	-0.19	0.009	1000.0	-1000.0	-0.058	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	194.0	17.0	-0.057	0.008	1000.0	-1000.0	-0.074	-1000.0
JNK signaling in the CD4+ TCR pathway	10.0	175.0	17.0	-0.044	0.022	1000.0	-1000.0	-0.08	-1000.0
S1P1 pathway	10.0	378.0	36.0	-0.061	0.01	1000.0	-1000.0	-0.086	-1000.0
Effects of Botulinum toxin	10.0	274.0	26.0	-0.071	0.005	1000.0	-1000.0	-0.07	-1000.0
BCR signaling pathway	10.0	1080.0	99.0	-0.113	0.04	1000.0	-1000.0	-0.11	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	328.0	34.0	-0.029	0.0	1000.0	-1000.0	-0.072	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	734.0	74.0	-0.171	0.068	1000.0	-1000.0	-0.116	-1000.0
Syndecan-4-mediated signaling events	9.0	623.0	67.0	-0.168	0.01	1000.0	-1000.0	-0.111	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	242.0	28.0	-0.181	0.02	1000.0	-1000.0	-0.065	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	583.0	65.0	-0.598	0.044	1000.0	-1000.0	-0.091	-1000.0
IL2 signaling events mediated by STAT5	8.0	183.0	22.0	-0.148	0.06	1000.0	-1000.0	-0.071	-1000.0
S1P4 pathway	8.0	220.0	25.0	-0.065	0.003	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PTP1B	7.0	550.0	76.0	-0.102	0.033	1000.0	-1000.0	-0.1	-1000.0
TRAIL signaling pathway	7.0	366.0	48.0	-0.096	0.046	1000.0	-1000.0	-0.083	-1000.0
Cellular roles of Anthrax toxin	6.0	263.0	39.0	-0.092	0.017	1000.0	-1000.0	-0.042	-1000.0
Retinoic acid receptors-mediated signaling	6.0	381.0	58.0	-0.221	0.034	1000.0	-1000.0	-0.092	-1000.0
Regulation of p38-alpha and p38-beta	6.0	353.0	54.0	-0.087	0.036	1000.0	-1000.0	-0.086	-1000.0
LPA receptor mediated events	6.0	635.0	102.0	-0.102	0.035	1000.0	-1000.0	-0.11	-1000.0
S1P3 pathway	6.0	273.0	42.0	-0.181	0.041	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by PRL	6.0	209.0	34.0	-0.127	0.028	1000.0	-1000.0	-0.074	-1000.0
BARD1 signaling events	5.0	304.0	57.0	-0.127	0.022	1000.0	-1000.0	-0.077	-1000.0
IL2 signaling events mediated by PI3K	5.0	307.0	58.0	-0.226	0.074	1000.0	-1000.0	-0.099	-1000.0
IL27-mediated signaling events	5.0	295.0	51.0	-0.118	0.011	1000.0	-1000.0	-0.109	-1000.0
IGF1 pathway	5.0	326.0	57.0	-0.021	0.04	1000.0	-1000.0	-0.119	-1000.0
Insulin Pathway	5.0	381.0	74.0	-0.105	0.032	1000.0	-1000.0	-0.116	-1000.0
ErbB2/ErbB3 signaling events	4.0	274.0	65.0	-0.078	0.054	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class II	4.0	350.0	75.0	-0.081	0.0	1000.0	-1000.0	-0.076	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	20.0	5.0	-0.009	-0.001	1000.0	-1000.0	-0.041	-1000.0
IL1-mediated signaling events	4.0	298.0	62.0	-0.061	0.042	1000.0	-1000.0	-0.134	-1000.0
Ephrin B reverse signaling	4.0	215.0	48.0	-0.071	0.04	1000.0	-1000.0	-0.081	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	384.0	83.0	-0.069	0.05	1000.0	-1000.0	-0.096	-1000.0
EPHB forward signaling	4.0	349.0	85.0	-0.072	0.033	1000.0	-1000.0	-0.112	-1000.0
Class I PI3K signaling events	4.0	341.0	73.0	-0.054	0.026	1000.0	-1000.0	-0.076	-1000.0
Arf6 trafficking events	4.0	301.0	71.0	-0.085	0.032	1000.0	-1000.0	-0.09	-1000.0
Regulation of Telomerase	4.0	408.0	102.0	-0.118	0.025	1000.0	-1000.0	-0.124	-1000.0
p38 MAPK signaling pathway	4.0	219.0	44.0	-0.069	0.034	1000.0	-1000.0	-0.073	-1000.0
IFN-gamma pathway	3.0	244.0	68.0	-0.069	0.065	1000.0	-1000.0	-0.126	-1000.0
Signaling events mediated by HDAC Class I	3.0	396.0	104.0	-0.081	0.041	1000.0	-1000.0	-0.088	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	139.0	45.0	-0.027	0.061	1000.0	-1000.0	-0.116	-1000.0
TCGA08_rtk_signaling	3.0	90.0	26.0	-0.065	0.038	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	3.0	212.0	56.0	-0.202	0.043	1000.0	-1000.0	-0.096	-1000.0
Circadian rhythm pathway	2.0	59.0	22.0	-0.032	0.038	1000.0	-1000.0	-0.077	-1000.0
Ceramide signaling pathway	2.0	159.0	76.0	-0.028	0.041	1000.0	-1000.0	-0.074	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	101.0	37.0	-0.012	0.025	1000.0	-1000.0	-0.093	-1000.0
PDGFR-beta signaling pathway	2.0	224.0	97.0	-0.044	0.054	1000.0	-1000.0	-0.117	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.022	-1000.0
Insulin-mediated glucose transport	1.0	52.0	32.0	-0.057	0.034	1000.0	-1000.0	-0.073	-1000.0
S1P5 pathway	1.0	30.0	17.0	-0.01	0.006	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	1.0	97.0	64.0	-0.089	0.081	1000.0	-1000.0	-0.105	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.001	0.027	1000.0	-1000.0	-0.057	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	43.0	36.0	-0.01	0.02	1000.0	-1000.0	-0.082	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.007	0.007	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	1.0	62.0	43.0	-0.023	0.043	1000.0	-1000.0	-0.091	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.036	1000.0	-1000.0	-0.086	-1000.0
Canonical NF-kappaB pathway	0.0	33.0	39.0	-0.019	0.072	1000.0	-1000.0	-0.111	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.001	0.019	1000.0	-1000.0	-0.03	-1000.0
Arf6 downstream pathway	0.0	21.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.046	-1000.0
EPO signaling pathway	0.0	52.0	55.0	-0.007	0.066	1000.0	-1000.0	-0.124	-1000.0
mTOR signaling pathway	0.0	14.0	53.0	-0.004	0.03	1000.0	-1000.0	-0.078	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	60.0	68.0	-0.057	0.043	1000.0	-1000.0	-0.086	-1000.0
ceramide signaling pathway	0.0	47.0	49.0	-0.013	0.044	1000.0	-1000.0	-0.071	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	-0.001	0.03	1000.0	-1000.0	-0.083	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	54.0	76.0	-0.026	0.053	1000.0	-1000.0	-0.109	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.001	0.025	1000.0	-1000.0	-0.068	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.0	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	32.0	54.0	-0.022	0.022	1000.0	-1000.0	-0.062	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.001	0.0	1000.0	-1000.0	-0.079	-1000.0
Total	2623	165115	7203	-24.936240564	-994.699286097	131000	-131000	-11.7722956677	-131000