GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in MESO-TP

Mesothelioma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in MESO-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1P849ZT

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 191
Number of samples: 86
Original number of Gene Sets: 404
Maximum gene set size: 388

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 4 :[ clus1 ] 26
pheno.type: 2 - 4 :[ clus2 ] 22
pheno.type: 3 - 4 :[ clus3 ] 17
pheno.type: 4 - 4 :[ clus4 ] 21

For the expression subtypes of 18203 genes in 87 samples, GSEA found enriched gene sets in each cluster using 86 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are BIOCARTA DEATH PATHWAY, KEGG GLYCOLYSIS GLUCONEOGENESIS, KEGG FATTY ACID METABOLISM, KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM, KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION, KEGG TYROSINE METABOLISM, KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM, KEGG SPHINGOLIPID METABOLISM, KEGG PROPANOATE METABOLISM, KEGG BUTANOATE METABOLISM

And common core enriched genes are ADH1A, ADH1B, ADH1C, ADH4, ADH6, ALDH2, ALDH3A2, ACADS, ADH5, ALDH3B1

clus2

Top enriched gene sets are BIOCARTA CHREBP2 PATHWAY, BIOCARTA RHO PATHWAY, KEGG GLYCOLYSIS GLUCONEOGENESIS, KEGG CITRATE CYCLE TCA CYCLE, KEGG STEROID HORMONE BIOSYNTHESIS, KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION, KEGG ARGININE AND PROLINE METABOLISM, KEGG HISTIDINE METABOLISM, KEGG TYROSINE METABOLISM, KEGG TRYPTOPHAN METABOLISM

And common core enriched genes are ALDH1B1, ALDH7A1, ALDH1A3, ALDH3A1, MAOA, MAOB, ABAT, ACAT1, AOX1, EHHADH

clus3

Top enriched gene sets are BIOCARTA BCR PATHWAY, BIOCARTA HIVNEF PATHWAY, BIOCARTA IL2RB PATHWAY, BIOCARTA RACCYCD PATHWAY, BIOCARTA INTEGRIN PATHWAY, BIOCARTA TCR PATHWAY, BIOCARTA VEGF PATHWAY, KEGG PROTEASOME, KEGG CHEMOKINE SIGNALING PATHWAY, KEGG CELL CYCLE

And common core enriched genes are PIK3CG, TNF, AKT3, CHUK, NFKB1, NFKBIA, PIK3R3, PIK3R5, SHC1, TGFB1

clus4

Top enriched gene sets are BIOCARTA ALK PATHWAY, BIOCARTA G1 PATHWAY, BIOCARTA WNT PATHWAY, KEGG PURINE METABOLISM, KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES, KEGG CALCIUM SIGNALING PATHWAY, KEGG OOCYTE MEIOSIS, KEGG VASCULAR SMOOTH MUSCLE CONTRACTION, KEGG WNT SIGNALING PATHWAY, KEGG NOTCH SIGNALING PATHWAY

And common core enriched genes are FZD1, FZD10, FZD2, FZD3, FZD4, FZD7, FZD8, FZD9, LEF1, TCF7

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA DEATH PATHWAY	32	genes.ES.table	0.33	1.2	0.27	0.94	1	0.31	0.17	0.26	0.84	0.39
KEGG GLYCOLYSIS GLUCONEOGENESIS	55	genes.ES.table	0.46	1.5	0.037	1	0.85	0.22	0.1	0.2	0.88	0.45
KEGG FATTY ACID METABOLISM	39	genes.ES.table	0.61	1.9	0	0.16	0.13	0.33	0.12	0.3	0	0.045
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM	29	genes.ES.table	0.38	1.2	0.18	1	1	0.24	0.087	0.22	0.9	0.43
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION	42	genes.ES.table	0.33	1.2	0.29	0.98	1	0.52	0.28	0.38	0.89	0.42
KEGG TYROSINE METABOLISM	40	genes.ES.table	0.52	1.4	0.04	0.87	0.94	0.25	0.059	0.24	0.67	0.3
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM	42	genes.ES.table	0.42	1.5	0.098	0.91	0.92	0.24	0.11	0.21	0.67	0.32
KEGG SPHINGOLIPID METABOLISM	37	genes.ES.table	0.38	1.2	0.25	0.9	1	0.27	0.14	0.23	0.83	0.35
KEGG PROPANOATE METABOLISM	31	genes.ES.table	0.35	1.1	0.33	0.96	1	0.39	0.23	0.3	0.9	0.4
KEGG BUTANOATE METABOLISM	28	genes.ES.table	0.49	1.5	0.052	1	0.88	0.29	0.1	0.26	0.74	0.36

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADH6	ADH6	ADH6	1	1.3	0.17	YES
2	ADH1A	ADH1A	ADH1A	2	1.2	0.32	YES
3	ADH1B	ADH1B	ADH1B	13	0.79	0.43	YES
4	ACSL6	ACSL6	ACSL6	341	0.4	0.47	YES
5	ADH1C	ADH1C	ADH1C	640	0.31	0.49	YES
6	ADH4	ADH4	ADH4	671	0.3	0.53	YES
7	ALDH3A2	ALDH3A2	ALDH3A2	1083	0.23	0.54	YES
8	ACSL5	ACSL5	ACSL5	1103	0.22	0.56	YES
9	ACADS	ACADS	ACADS	1421	0.19	0.57	YES
10	ADH5	ADH5	ADH5	1713	0.16	0.58	YES
11	ALDH2	ALDH2	ALDH2	1818	0.15	0.59	YES
12	ACADM	ACADM	ACADM	2007	0.14	0.6	YES
13	ACSL1	ACSL1	ACSL1	2123	0.13	0.61	YES
14	CPT2	CPT2	CPT2	3144	0.086	0.57	NO
15	DCI	DCI	DCI	3614	0.072	0.55	NO
16	ALDH9A1	ALDH9A1	ALDH9A1	4232	0.057	0.52	NO
17	HADHB	HADHB	HADHB	4613	0.048	0.51	NO
18	ACAA2	ACAA2	ACAA2	4738	0.045	0.51	NO
19	ACADVL	ACADVL	ACADVL	4804	0.044	0.51	NO
20	HADH	HADH	HADH	5060	0.039	0.5	NO
21	ECHS1	ECHS1	ECHS1	5469	0.032	0.48	NO
22	CPT1B	CPT1B	CPT1B	5643	0.029	0.48	NO
23	ACAA1	ACAA1	ACAA1	6207	0.021	0.45	NO
24	HADHA	HADHA	HADHA	6751	0.013	0.42	NO
25	CPT1A	CPT1A	CPT1A	6781	0.012	0.42	NO
26	ALDH7A1	ALDH7A1	ALDH7A1	7531	0.0023	0.38	NO
27	ACAT2	ACAT2	ACAT2	7596	0.0014	0.38	NO
28	ACAT1	ACAT1	ACAT1	8804	-0.016	0.32	NO
29	ACADSB	ACADSB	ACADSB	9017	-0.02	0.31	NO
30	GCDH	GCDH	GCDH	9555	-0.028	0.28	NO
31	ACSL3	ACSL3	ACSL3	10411	-0.042	0.24	NO
32	ACOX3	ACOX3	ACOX3	11730	-0.07	0.18	NO
33	ACADL	ACADL	ACADL	12986	-0.11	0.12	NO
34	ACSL4	ACSL4	ACSL4	13053	-0.11	0.13	NO
35	PECI	PECI	PECI	13641	-0.13	0.12	NO
36	ALDH1B1	ALDH1B1	ALDH1B1	14707	-0.18	0.082	NO
37	CYP4A11	CYP4A11	CYP4A11	15329	-0.22	0.076	NO
38	EHHADH	EHHADH	EHHADH	16376	-0.29	0.057	NO
39	CPT1C	CPT1C	CPT1C	16689	-0.32	0.082	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADH6	ADH6	ADH6	1	1.3	0.13	YES
2	ADH1A	ADH1A	ADH1A	2	1.2	0.25	YES
3	ADH1B	ADH1B	ADH1B	13	0.79	0.34	YES
4	ALDH3B2	ALDH3B2	ALDH3B2	520	0.33	0.34	YES
5	ADH1C	ADH1C	ADH1C	640	0.31	0.37	YES
6	ADH4	ADH4	ADH4	671	0.3	0.4	YES
7	ALDH3B1	ALDH3B1	ALDH3B1	849	0.26	0.42	YES
8	PGM1	PGM1	PGM1	910	0.25	0.44	YES
9	ALDH3A2	ALDH3A2	ALDH3A2	1083	0.23	0.45	YES
10	PGM2	PGM2	PGM2	1669	0.16	0.44	YES
11	ADH5	ADH5	ADH5	1713	0.16	0.45	YES
12	ALDH2	ALDH2	ALDH2	1818	0.15	0.46	YES
13	PFKM	PFKM	PFKM	3235	0.084	0.39	NO
14	LDHA	LDHA	LDHA	3333	0.08	0.4	NO
15	PDHB	PDHB	PDHB	3497	0.075	0.39	NO
16	PCK2	PCK2	PCK2	3642	0.071	0.39	NO
17	HK2	HK2	HK2	3693	0.07	0.4	NO
18	ALDH9A1	ALDH9A1	ALDH9A1	4232	0.057	0.38	NO
19	DLD	DLD	DLD	4312	0.055	0.38	NO
20	DLAT	DLAT	DLAT	4464	0.051	0.37	NO
21	ALDOA	ALDOA	ALDOA	4999	0.04	0.35	NO
22	ACSS2	ACSS2	ACSS2	5305	0.035	0.34	NO
23	GPI	GPI	GPI	5338	0.035	0.34	NO
24	PGAM1	PGAM1	PGAM1	5522	0.032	0.33	NO
25	AKR1A1	AKR1A1	AKR1A1	5961	0.024	0.31	NO
26	PGAM4	PGAM4	PGAM4	6134	0.022	0.3	NO
27	ENO1	ENO1	ENO1	6254	0.02	0.3	NO
28	TPI1	TPI1	TPI1	6709	0.013	0.27	NO
29	PFKL	PFKL	PFKL	6941	0.01	0.26	NO
30	ALDH7A1	ALDH7A1	ALDH7A1	7531	0.0023	0.23	NO
31	PFKP	PFKP	PFKP	7562	0.0018	0.23	NO
32	PGK1	PGK1	PGK1	7797	-0.0017	0.22	NO
33	LDHAL6A	LDHAL6A	LDHAL6A	8524	-0.012	0.18	NO
34	HK3	HK3	HK3	8609	-0.013	0.17	NO
35	PDHA1	PDHA1	PDHA1	9793	-0.032	0.11	NO
36	PKM2	PKM2	PKM2	9965	-0.035	0.1	NO
37	GAPDH	GAPDH	GAPDH	10062	-0.036	0.1	NO
38	FBP1	FBP1	FBP1	10107	-0.037	0.1	NO
39	LDHB	LDHB	LDHB	11151	-0.058	0.054	NO
40	ALDH3A1	ALDH3A1	ALDH3A1	11239	-0.06	0.055	NO
41	ENO2	ENO2	ENO2	12235	-0.083	0.009	NO
42	ACSS1	ACSS1	ACSS1	13114	-0.11	-0.028	NO
43	ENO3	ENO3	ENO3	13341	-0.12	-0.028	NO
44	BPGM	BPGM	BPGM	13894	-0.14	-0.043	NO
45	ALDOB	ALDOB	ALDOB	14515	-0.17	-0.06	NO
46	PKLR	PKLR	PKLR	14678	-0.18	-0.051	NO
47	ALDH1B1	ALDH1B1	ALDH1B1	14707	-0.18	-0.034	NO
48	HK1	HK1	HK1	14745	-0.18	-0.017	NO
49	GALM	GALM	GALM	14883	-0.19	-0.005	NO
50	LDHAL6B	LDHAL6B	LDHAL6B	15461	-0.22	-0.014	NO
51	PCK1	PCK1	PCK1	15695	-0.24	-0.0015	NO
52	PGAM2	PGAM2	PGAM2	16218	-0.28	-0.0013	NO
53	ALDOC	ALDOC	ALDOC	16399	-0.29	0.019	NO
54	GCK	GCK	GCK	16619	-0.31	0.04	NO
55	ALDH1A3	ALDH1A3	ALDH1A3	17650	-0.45	0.03	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACSM1	ACSM1	ACSM1	310	0.41	0.11	YES
2	BDH2	BDH2	BDH2	817	0.27	0.17	YES
3	ALDH5A1	ALDH5A1	ALDH5A1	855	0.26	0.24	YES
4	ALDH3A2	ALDH3A2	ALDH3A2	1083	0.23	0.3	YES
5	AACS	AACS	AACS	1163	0.21	0.36	YES
6	ACADS	ACADS	ACADS	1421	0.19	0.41	YES
7	ABAT	ABAT	ABAT	1582	0.17	0.45	YES
8	ALDH2	ALDH2	ALDH2	1818	0.15	0.49	YES
9	HMGCL	HMGCL	HMGCL	3421	0.077	0.42	NO
10	PDHB	PDHB	PDHB	3497	0.075	0.44	NO
11	ALDH9A1	ALDH9A1	ALDH9A1	4232	0.057	0.42	NO
12	ACSM5	ACSM5	ACSM5	4575	0.049	0.42	NO
13	HADH	HADH	HADH	5060	0.039	0.4	NO
14	ECHS1	ECHS1	ECHS1	5469	0.032	0.39	NO
15	HADHA	HADHA	HADHA	6751	0.013	0.32	NO
16	L2HGDH	L2HGDH	L2HGDH	6842	0.012	0.32	NO
17	ALDH7A1	ALDH7A1	ALDH7A1	7531	0.0023	0.28	NO
18	ACAT2	ACAT2	ACAT2	7596	0.0014	0.28	NO
19	ACAT1	ACAT1	ACAT1	8804	-0.016	0.22	NO
20	GAD1	GAD1	GAD1	8826	-0.017	0.22	NO
21	PDHA1	PDHA1	PDHA1	9793	-0.032	0.18	NO
22	OXCT1	OXCT1	OXCT1	11053	-0.056	0.13	NO
23	ACSM3	ACSM3	ACSM3	11744	-0.071	0.11	NO
24	AKR1B10	AKR1B10	AKR1B10	12346	-0.087	0.1	NO
25	BDH1	BDH1	BDH1	13113	-0.11	0.097	NO
26	HMGCS1	HMGCS1	HMGCS1	13912	-0.14	0.097	NO
27	ALDH1B1	ALDH1B1	ALDH1B1	14707	-0.18	0.11	NO
28	OXCT2	OXCT2	OXCT2	16148	-0.27	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GFPT2	GFPT2	GFPT2	386	0.38	0.073	YES
2	GALK2	GALK2	GALK2	907	0.25	0.11	YES
3	PGM1	PGM1	PGM1	910	0.25	0.17	YES
4	CHIT1	CHIT1	CHIT1	1044	0.23	0.22	YES
5	UGP2	UGP2	UGP2	1353	0.19	0.25	YES
6	FPGT	FPGT	FPGT	1436	0.18	0.29	YES
7	GALE	GALE	GALE	1442	0.18	0.34	YES
8	FUK	FUK	FUK	1539	0.18	0.38	YES
9	PGM2	PGM2	PGM2	1669	0.16	0.41	YES
10	AMDHD2	AMDHD2	AMDHD2	2071	0.13	0.42	YES
11	PMM2	PMM2	PMM2	2965	0.092	0.4	NO
12	NANP	NANP	NANP	3499	0.075	0.38	NO
13	MPI	MPI	MPI	3621	0.072	0.4	NO
14	HK2	HK2	HK2	3693	0.07	0.41	NO
15	UGDH	UGDH	UGDH	4340	0.054	0.39	NO
16	CMAS	CMAS	CMAS	4470	0.051	0.39	NO
17	GMPPB	GMPPB	GMPPB	5014	0.04	0.37	NO
18	GNPDA1	GNPDA1	GNPDA1	5306	0.035	0.36	NO
19	GPI	GPI	GPI	5338	0.035	0.37	NO
20	HEXA	HEXA	HEXA	5399	0.034	0.38	NO
21	GFPT1	GFPT1	GFPT1	5671	0.029	0.37	NO
22	GMPPA	GMPPA	GMPPA	5768	0.027	0.37	NO
23	GMDS	GMDS	GMDS	6273	0.02	0.35	NO
24	GALT	GALT	GALT	6372	0.018	0.35	NO
25	GALK1	GALK1	GALK1	6418	0.018	0.35	NO
26	RENBP	RENBP	RENBP	7453	0.0034	0.29	NO
27	TSTA3	TSTA3	TSTA3	7598	0.0013	0.28	NO
28	NAGK	NAGK	NAGK	7875	-0.0026	0.27	NO
29	PMM1	PMM1	PMM1	8538	-0.012	0.24	NO
30	HK3	HK3	HK3	8609	-0.013	0.24	NO
31	NANS	NANS	NANS	8638	-0.014	0.24	NO
32	CYB5R1	CYB5R1	CYB5R1	8720	-0.015	0.24	NO
33	NPL	NPL	NPL	8848	-0.017	0.24	NO
34	HEXB	HEXB	HEXB	8970	-0.019	0.23	NO
35	UXS1	UXS1	UXS1	9906	-0.034	0.19	NO
36	UAP1	UAP1	UAP1	10014	-0.036	0.19	NO
37	PGM3	PGM3	PGM3	12099	-0.08	0.098	NO
38	GNPDA2	GNPDA2	GNPDA2	12106	-0.08	0.12	NO
39	GNE	GNE	GNE	14120	-0.15	0.044	NO
40	HK1	HK1	HK1	14745	-0.18	0.055	NO
41	GNPNAT1	GNPNAT1	GNPNAT1	15609	-0.23	0.065	NO
42	GCK	GCK	GCK	16619	-0.31	0.086	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADH6	ADH6	ADH6	1	1.3	0.14	YES
2	ADH1A	ADH1A	ADH1A	2	1.2	0.26	YES
3	ADH1B	ADH1B	ADH1B	13	0.79	0.35	YES
4	TAT	TAT	TAT	143	0.51	0.4	YES
5	ALDH3B2	ALDH3B2	ALDH3B2	520	0.33	0.41	YES
6	ADH1C	ADH1C	ADH1C	640	0.31	0.44	YES
7	ADH4	ADH4	ADH4	671	0.3	0.47	YES
8	ALDH3B1	ALDH3B1	ALDH3B1	849	0.26	0.48	YES
9	AOC2	AOC2	AOC2	935	0.25	0.51	YES
10	DCT	DCT	DCT	1069	0.23	0.52	YES
11	ADH5	ADH5	ADH5	1713	0.16	0.51	NO
12	HPD	HPD	HPD	2896	0.094	0.45	NO
13	GSTZ1	GSTZ1	GSTZ1	2945	0.092	0.46	NO
14	LCMT2	LCMT2	LCMT2	3105	0.087	0.46	NO
15	METTL6	METTL6	METTL6	3422	0.077	0.45	NO
16	MIF	MIF	MIF	3857	0.065	0.43	NO
17	GOT1	GOT1	GOT1	4102	0.06	0.43	NO
18	TPO	TPO	TPO	5344	0.034	0.36	NO
19	METTL2B	METTL2B	METTL2B	7599	0.0013	0.24	NO
20	MAOB	MAOB	MAOB	7718	-0.00055	0.23	NO
21	DDC	DDC	DDC	8694	-0.014	0.18	NO
22	COMT	COMT	COMT	8702	-0.015	0.18	NO
23	FAH	FAH	FAH	8771	-0.016	0.18	NO
24	IL4I1	IL4I1	IL4I1	9149	-0.022	0.16	NO
25	WBSCR22	WBSCR22	WBSCR22	9357	-0.025	0.15	NO
26	ALDH3A1	ALDH3A1	ALDH3A1	11239	-0.06	0.054	NO
27	LCMT1	LCMT1	LCMT1	11441	-0.064	0.05	NO
28	GOT2	GOT2	GOT2	11988	-0.077	0.028	NO
29	TRMT11	TRMT11	TRMT11	12908	-0.1	-0.012	NO
30	TYR	TYR	TYR	13600	-0.13	-0.036	NO
31	HEMK1	HEMK1	HEMK1	13667	-0.13	-0.025	NO
32	NAT6	NAT6	NAT6	13840	-0.14	-0.02	NO
33	AOX1	AOX1	AOX1	15163	-0.2	-0.07	NO
34	TH	TH	TH	15317	-0.21	-0.056	NO
35	HGD	HGD	HGD	15536	-0.23	-0.043	NO
36	AOC3	AOC3	AOC3	15746	-0.24	-0.029	NO
37	DBH	DBH	DBH	16682	-0.32	-0.046	NO
38	PNMT	PNMT	PNMT	16709	-0.32	-0.014	NO
39	MAOA	MAOA	MAOA	17583	-0.43	-0.015	NO
40	ALDH1A3	ALDH1A3	ALDH1A3	17650	-0.45	0.03	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GPR37	GPR37	GPR37	135	0.52	0.066	YES
2	SNCA	SNCA	SNCA	393	0.38	0.1	YES
3	PARK2	PARK2	PARK2	801	0.27	0.12	YES
4	SLC6A3	SLC6A3	SLC6A3	1192	0.21	0.13	YES
5	SLC25A4	SLC25A4	SLC25A4	1242	0.2	0.15	YES
6	NDUFC1	NDUFC1	NDUFC1	1445	0.18	0.17	YES
7	UBE2L6	UBE2L6	UBE2L6	1824	0.15	0.17	YES
8	NDUFB1	NDUFB1	NDUFB1	1904	0.14	0.18	YES
9	CASP3	CASP3	CASP3	2083	0.13	0.19	YES
10	NDUFB5	NDUFB5	NDUFB5	2511	0.11	0.19	YES
11	COX7A1	COX7A1	COX7A1	2793	0.099	0.18	YES
12	ATP5G1	ATP5G1	ATP5G1	3037	0.089	0.18	YES
13	ATP5H	ATP5H	ATP5H	3065	0.088	0.2	YES
14	NDUFA2	NDUFA2	NDUFA2	3110	0.087	0.2	YES
15	CASP9	CASP9	CASP9	3126	0.087	0.22	YES
16	ATP5G3	ATP5G3	ATP5G3	3195	0.085	0.22	YES
17	NDUFA3	NDUFA3	NDUFA3	3388	0.079	0.22	YES
18	NDUFB4	NDUFB4	NDUFB4	3542	0.074	0.23	YES
19	SDHD	SDHD	SDHD	3648	0.071	0.23	YES
20	COX7C	COX7C	COX7C	3775	0.068	0.23	YES
21	UQCR10	UQCR10	UQCR10	3849	0.066	0.24	YES
22	NDUFV3	NDUFV3	NDUFV3	3858	0.065	0.25	YES
23	COX5B	COX5B	COX5B	3887	0.065	0.26	YES
24	SLC25A6	SLC25A6	SLC25A6	3897	0.064	0.26	YES
25	NDUFB6	NDUFB6	NDUFB6	3928	0.064	0.27	YES
26	ATP5F1	ATP5F1	ATP5F1	3954	0.063	0.28	YES
27	COX8C	COX8C	COX8C	3959	0.063	0.29	YES
28	UBE2J2	UBE2J2	UBE2J2	4030	0.061	0.29	YES
29	NDUFA7	NDUFA7	NDUFA7	4063	0.06	0.3	YES
30	NDUFS8	NDUFS8	NDUFS8	4173	0.058	0.3	YES
31	NDUFS4	NDUFS4	NDUFS4	4238	0.057	0.3	YES
32	ATP5A1	ATP5A1	ATP5A1	4243	0.057	0.31	YES
33	UQCRFS1	UQCRFS1	UQCRFS1	4264	0.056	0.32	YES
34	HTRA2	HTRA2	HTRA2	4356	0.053	0.32	YES
35	ATP5C1	ATP5C1	ATP5C1	4425	0.052	0.33	YES
36	COX6A1	COX6A1	COX6A1	4499	0.05	0.33	YES
37	ATP5B	ATP5B	ATP5B	4525	0.05	0.33	YES
38	PARK7	PARK7	PARK7	4678	0.046	0.33	YES
39	PINK1	PINK1	PINK1	4689	0.046	0.34	YES
40	UBA7	UBA7	UBA7	4698	0.046	0.34	YES
41	UQCRB	UQCRB	UQCRB	4795	0.044	0.34	YES
42	COX7B	COX7B	COX7B	4924	0.042	0.34	YES
43	NDUFV1	NDUFV1	NDUFV1	4942	0.042	0.35	YES
44	ATP5G2	ATP5G2	ATP5G2	4991	0.041	0.35	YES
45	NDUFA10	NDUFA10	NDUFA10	5054	0.039	0.35	YES
46	NDUFB3	NDUFB3	NDUFB3	5069	0.039	0.36	YES
47	UQCRQ	UQCRQ	UQCRQ	5117	0.038	0.36	YES
48	ATP5O	ATP5O	ATP5O	5140	0.038	0.37	YES
49	NDUFS5	NDUFS5	NDUFS5	5153	0.038	0.37	YES
50	NDUFA9	NDUFA9	NDUFA9	5377	0.034	0.36	YES
51	COX4I1	COX4I1	COX4I1	5403	0.034	0.37	YES
52	NDUFB10	NDUFB10	NDUFB10	5417	0.033	0.37	YES
53	NDUFB7	NDUFB7	NDUFB7	5512	0.032	0.37	YES
54	NDUFA8	NDUFA8	NDUFA8	5541	0.031	0.37	YES
55	UQCR11	UQCR11	UQCR11	5567	0.031	0.38	YES
56	VDAC2	VDAC2	VDAC2	5612	0.03	0.38	YES
57	UQCRC2	UQCRC2	UQCRC2	5771	0.027	0.37	YES
58	COX8A	COX8A	COX8A	5813	0.026	0.37	YES
59	NDUFS3	NDUFS3	NDUFS3	5823	0.026	0.38	YES
60	COX6C	COX6C	COX6C	5847	0.026	0.38	YES
61	ATP5J	ATP5J	ATP5J	5874	0.025	0.38	YES
62	COX7A2L	COX7A2L	COX7A2L	5938	0.025	0.38	YES
63	SDHA	SDHA	SDHA	6020	0.024	0.38	YES
64	NDUFB2	NDUFB2	NDUFB2	6048	0.023	0.38	YES
65	UBE2L3	UBE2L3	UBE2L3	6129	0.022	0.38	YES
66	NDUFB8	NDUFB8	NDUFB8	6149	0.022	0.38	YES
67	NDUFS1	NDUFS1	NDUFS1	6173	0.021	0.38	YES
68	SDHB	SDHB	SDHB	6182	0.021	0.39	YES
69	UBB	UBB	UBB	6302	0.02	0.38	NO
70	NDUFV2	NDUFV2	NDUFV2	6475	0.017	0.38	NO
71	NDUFA1	NDUFA1	NDUFA1	6557	0.016	0.37	NO
72	CYCS	CYCS	CYCS	6572	0.015	0.38	NO
73	NDUFS2	NDUFS2	NDUFS2	6601	0.015	0.38	NO
74	UBA1	UBA1	UBA1	6606	0.015	0.38	NO
75	NDUFC2	NDUFC2	NDUFC2	6933	0.01	0.36	NO
76	VDAC3	VDAC3	VDAC3	6982	0.0096	0.36	NO
77	NDUFA4	NDUFA4	NDUFA4	6988	0.0095	0.36	NO
78	ATP5E	ATP5E	ATP5E	7044	0.0088	0.36	NO
79	CYC1	CYC1	CYC1	7207	0.0068	0.35	NO
80	ATP5D	ATP5D	ATP5D	7433	0.0036	0.34	NO
81	NDUFS7	NDUFS7	NDUFS7	7585	0.0015	0.33	NO
82	NDUFA5	NDUFA5	NDUFA5	7606	0.0012	0.33	NO
83	UQCRHL	UQCRHL	UQCRHL	7725	-0.00062	0.32	NO
84	UQCRH	UQCRH	UQCRH	7834	-0.0021	0.32	NO
85	PPID	PPID	PPID	7843	-0.0022	0.32	NO
86	COX7A2	COX7A2	COX7A2	7866	-0.0025	0.32	NO
87	COX5A	COX5A	COX5A	8017	-0.0048	0.31	NO
88	SDHC	SDHC	SDHC	8170	-0.0068	0.3	NO
89	NDUFAB1	NDUFAB1	NDUFAB1	8329	-0.0094	0.29	NO
90	COX6B1	COX6B1	COX6B1	8469	-0.011	0.29	NO
91	NDUFS6	NDUFS6	NDUFS6	8569	-0.013	0.28	NO
92	NDUFB9	NDUFB9	NDUFB9	8587	-0.013	0.28	NO
93	UBE2G2	UBE2G2	UBE2G2	8896	-0.018	0.27	NO
94	UBE2J1	UBE2J1	UBE2J1	9007	-0.019	0.27	NO
95	SLC25A5	SLC25A5	SLC25A5	9571	-0.028	0.24	NO
96	VDAC1	VDAC1	VDAC1	9658	-0.03	0.24	NO
97	NDUFA6	NDUFA6	NDUFA6	10364	-0.042	0.21	NO
98	UQCRC1	UQCRC1	UQCRC1	10462	-0.043	0.21	NO
99	UBE2G1	UBE2G1	UBE2G1	10514	-0.044	0.21	NO
100	SNCAIP	SNCAIP	SNCAIP	11117	-0.057	0.19	NO
101	NDUFA4L2	NDUFA4L2	NDUFA4L2	11319	-0.062	0.18	NO
102	SLC18A1	SLC18A1	SLC18A1	11425	-0.064	0.19	NO
103	LRRK2	LRRK2	LRRK2	12386	-0.088	0.15	NO
104	APAF1	APAF1	APAF1	13002	-0.11	0.13	NO
105	UCHL1	UCHL1	UCHL1	14023	-0.14	0.091	NO
106	SLC18A2	SLC18A2	SLC18A2	14444	-0.16	0.09	NO
107	COX6A2	COX6A2	COX6A2	14495	-0.16	0.11	NO
108	COX6B2	COX6B2	COX6B2	15122	-0.2	0.1	NO
109	TH	TH	TH	15317	-0.21	0.12	NO
110	COX4I2	COX4I2	COX4I2	15785	-0.24	0.13	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ZBP1	ZBP1	ZBP1	193	0.47	0.095	YES
2	DDX58	DDX58	DDX58	394	0.38	0.17	YES
3	IRF7	IRF7	IRF7	516	0.33	0.24	YES
4	IFNB1	IFNB1	IFNB1	614	0.31	0.3	YES
5	IL1B	IL1B	IL1B	840	0.26	0.34	YES
6	IL18	IL18	IL18	892	0.25	0.4	YES
7	CASP1	CASP1	CASP1	1062	0.23	0.44	YES
8	CXCL10	CXCL10	CXCL10	1216	0.21	0.48	YES
9	NFKB1	NFKB1	NFKB1	2469	0.11	0.43	NO
10	CCL5	CCL5	CCL5	2488	0.11	0.46	NO
11	POLR3B	POLR3B	POLR3B	3245	0.083	0.43	NO
12	NFKBIA	NFKBIA	NFKBIA	3559	0.073	0.43	NO
13	PYCARD	PYCARD	PYCARD	4116	0.059	0.42	NO
14	CCL4	CCL4	CCL4	4272	0.056	0.42	NO
15	RIPK3	RIPK3	RIPK3	4512	0.05	0.42	NO
16	POLR1C	POLR1C	POLR1C	4632	0.047	0.42	NO
17	RIPK1	RIPK1	RIPK1	4653	0.047	0.43	NO
18	CCL4L2	CCL4L2	CCL4L2	4868	0.043	0.43	NO
19	MAVS	MAVS	MAVS	5145	0.038	0.42	NO
20	CHUK	CHUK	CHUK	5494	0.032	0.41	NO
21	ADAR	ADAR	ADAR	6218	0.02	0.38	NO
22	TREX1	TREX1	TREX1	6258	0.02	0.38	NO
23	TBK1	TBK1	TBK1	6773	0.012	0.35	NO
24	RELA	RELA	RELA	6940	0.01	0.34	NO
25	IKBKE	IKBKE	IKBKE	7298	0.0056	0.33	NO
26	IRF3	IRF3	IRF3	7933	-0.0036	0.29	NO
27	POLR1D	POLR1D	POLR1D	8110	-0.0061	0.28	NO
28	POLR3K	POLR3K	POLR3K	8413	-0.01	0.27	NO
29	IKBKB	IKBKB	IKBKB	8682	-0.014	0.26	NO
30	POLR3C	POLR3C	POLR3C	8722	-0.015	0.26	NO
31	POLR3A	POLR3A	POLR3A	9068	-0.02	0.24	NO
32	POLR3H	POLR3H	POLR3H	9670	-0.03	0.22	NO
33	AIM2	AIM2	AIM2	10237	-0.039	0.2	NO
34	IL6	IL6	IL6	11005	-0.054	0.16	NO
35	IKBKG	IKBKG	IKBKG	11219	-0.06	0.17	NO
36	POLR3GL	POLR3GL	POLR3GL	12142	-0.081	0.13	NO
37	NFKBIB	NFKBIB	NFKBIB	12614	-0.095	0.13	NO
38	TMEM173	TMEM173	TMEM173	12644	-0.096	0.15	NO
39	POLR3F	POLR3F	POLR3F	12692	-0.098	0.17	NO
40	POLR3D	POLR3D	POLR3D	13213	-0.12	0.16	NO
41	IL33	IL33	IL33	13804	-0.14	0.16	NO
42	POLR3G	POLR3G	POLR3G	17041	-0.35	0.063	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	DCP1B	DCP1B	DCP1B	2265	0.12	-0.08	YES
2	EXOSC9	EXOSC9	EXOSC9	2310	0.12	-0.039	YES
3	LSM3	LSM3	LSM3	2610	0.11	-0.018	YES
4	EXOSC6	EXOSC6	EXOSC6	2730	0.1	0.012	YES
5	PNPT1	PNPT1	PNPT1	3503	0.075	-0.0038	YES
6	SKIV2L2	SKIV2L2	SKIV2L2	3698	0.069	0.01	YES
7	LSM6	LSM6	LSM6	3715	0.069	0.034	YES
8	XRN1	XRN1	XRN1	4081	0.06	0.035	YES
9	CNOT4	CNOT4	CNOT4	4193	0.058	0.05	YES
10	CNOT6L	CNOT6L	CNOT6L	4580	0.049	0.046	YES
11	CNOT1	CNOT1	CNOT1	4719	0.046	0.055	YES
12	WDR61	WDR61	WDR61	4851	0.043	0.063	YES
13	C1D	C1D	C1D	5080	0.039	0.064	YES
14	NAA38	NAA38	NAA38	5342	0.034	0.062	YES
15	SKIV2L	SKIV2L	SKIV2L	5418	0.033	0.07	YES
16	CNOT6	CNOT6	CNOT6	5714	0.028	0.064	YES
17	EXOSC10	EXOSC10	EXOSC10	5746	0.028	0.072	YES
18	LSM5	LSM5	LSM5	5822	0.026	0.077	YES
19	PAPOLA	PAPOLA	PAPOLA	5843	0.026	0.086	YES
20	DDX6	DDX6	DDX6	5901	0.025	0.091	YES
21	EDC4	EDC4	EDC4	6195	0.021	0.083	YES
22	ENO1	ENO1	ENO1	6254	0.02	0.087	YES
23	LSM4	LSM4	LSM4	6311	0.019	0.09	YES
24	EXOSC3	EXOSC3	EXOSC3	6346	0.019	0.095	YES
25	PARN	PARN	PARN	6351	0.019	0.1	YES
26	CNOT2	CNOT2	CNOT2	6986	0.0095	0.07	YES
27	CNOT10	CNOT10	CNOT10	7059	0.0086	0.069	YES
28	CNOT7	CNOT7	CNOT7	7082	0.0084	0.071	YES
29	HSPD1	HSPD1	HSPD1	7091	0.0082	0.074	YES
30	DIS3	DIS3	DIS3	7492	0.0029	0.053	YES
31	EXOSC4	EXOSC4	EXOSC4	7518	0.0025	0.052	YES
32	LSM1	LSM1	LSM1	7699	-0.00035	0.042	YES
33	EXOSC8	EXOSC8	EXOSC8	7810	-0.0018	0.037	YES
34	HSPA9	HSPA9	HSPA9	7862	-0.0024	0.035	YES
35	PATL1	PATL1	PATL1	8041	-0.0052	0.027	YES
36	EXOSC5	EXOSC5	EXOSC5	9313	-0.024	-0.034	YES
37	EXOSC1	EXOSC1	EXOSC1	9453	-0.027	-0.033	YES
38	EXOSC2	EXOSC2	EXOSC2	10077	-0.037	-0.054	YES
39	XRN2	XRN2	XRN2	10447	-0.043	-0.059	YES
40	DCP2	DCP2	DCP2	10461	-0.043	-0.044	YES
41	TTC37	TTC37	TTC37	10657	-0.047	-0.038	YES
42	MPHOSPH6	MPHOSPH6	MPHOSPH6	10716	-0.048	-0.024	YES
43	CNOT3	CNOT3	CNOT3	10765	-0.049	-0.009	YES
44	LSM7	LSM7	LSM7	11197	-0.059	-0.012	YES
45	ZCCHC7	ZCCHC7	ZCCHC7	11224	-0.06	0.0083	YES
46	LSM2	LSM2	LSM2	11690	-0.07	0.0076	YES
47	DCP1A	DCP1A	DCP1A	12173	-0.082	0.01	YES
48	PAPOLB	PAPOLB	PAPOLB	12200	-0.082	0.038	YES
49	ENO2	ENO2	ENO2	12235	-0.083	0.066	YES
50	PAPOLG	PAPOLG	PAPOLG	12289	-0.085	0.094	YES
51	EDC3	EDC3	EDC3	12420	-0.089	0.12	YES
52	PAPD7	PAPD7	PAPD7	12576	-0.094	0.14	YES
53	DCPS	DCPS	DCPS	12995	-0.11	0.16	YES
54	RQCD1	RQCD1	RQCD1	13150	-0.11	0.19	YES
55	ENO3	ENO3	ENO3	13341	-0.12	0.22	YES
56	EXOSC7	EXOSC7	EXOSC7	13450	-0.12	0.26	YES

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	KIR2DL3	KIR2DL3	KIR2DL3	286	0.42	0.066	YES
2	HLA-G	HLA-G	HLA-G	420	0.37	0.13	YES
3	KLRC1	KLRC1	KLRC1	453	0.36	0.2	YES
4	KIR3DL1	KIR3DL1	KIR3DL1	592	0.32	0.25	YES
5	KLRD1	KLRD1	KLRD1	613	0.31	0.31	YES
6	KIR2DL1	KIR2DL1	KIR2DL1	677	0.3	0.36	YES
7	GZMB	GZMB	GZMB	819	0.27	0.41	YES
8	IL1B	IL1B	IL1B	840	0.26	0.46	YES
9	HLA-F	HLA-F	HLA-F	846	0.26	0.51	YES
10	PRF1	PRF1	PRF1	1185	0.21	0.53	YES
11	KIR3DL2	KIR3DL2	KIR3DL2	1504	0.18	0.55	YES
12	HLA-C	HLA-C	HLA-C	1913	0.14	0.55	YES
13	HLA-B	HLA-B	HLA-B	2059	0.14	0.57	YES
14	HLA-A	HLA-A	HLA-A	2270	0.12	0.58	YES
15	HLA-E	HLA-E	HLA-E	2281	0.12	0.6	YES
16	CD28	CD28	CD28	2299	0.12	0.63	YES
17	FASLG	FASLG	FASLG	2339	0.12	0.65	YES
18	TNF	TNF	TNF	3012	0.09	0.63	NO
19	HLA-DOB	HLA-DOB	HLA-DOB	3478	0.076	0.62	NO
20	CD86	CD86	CD86	6678	0.014	0.44	NO
21	FAS	FAS	FAS	6713	0.013	0.44	NO
22	HLA-DMA	HLA-DMA	HLA-DMA	6811	0.012	0.44	NO
23	HLA-DRB1	HLA-DRB1	HLA-DRB1	8432	-0.011	0.35	NO
24	IL2	IL2	IL2	8996	-0.019	0.33	NO
25	CD80	CD80	CD80	9363	-0.025	0.31	NO
26	HLA-DMB	HLA-DMB	HLA-DMB	9534	-0.028	0.31	NO
27	HLA-DRB5	HLA-DRB5	HLA-DRB5	10259	-0.04	0.28	NO
28	HLA-DRA	HLA-DRA	HLA-DRA	10522	-0.044	0.27	NO
29	HLA-DPA1	HLA-DPA1	HLA-DPA1	10766	-0.049	0.26	NO
30	IL6	IL6	IL6	11005	-0.054	0.26	NO
31	HLA-DPB1	HLA-DPB1	HLA-DPB1	11547	-0.066	0.24	NO
32	HLA-DQA2	HLA-DQA2	HLA-DQA2	11952	-0.076	0.24	NO
33	IFNG	IFNG	IFNG	13517	-0.13	0.18	NO
34	HLA-DOA	HLA-DOA	HLA-DOA	13704	-0.13	0.19	NO
35	HLA-DQA1	HLA-DQA1	HLA-DQA1	13884	-0.14	0.21	NO
36	IL1A	IL1A	IL1A	14074	-0.15	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SNCA	SNCA	SNCA	393	0.38	0.01	YES
2	PLCB1	PLCB1	PLCB1	449	0.36	0.038	YES
3	CHP	CHP	CHP	590	0.32	0.057	YES
4	ERN1	ERN1	ERN1	652	0.3	0.079	YES
5	CACNA1F	CACNA1F	CACNA1F	667	0.3	0.1	YES
6	IL1B	IL1B	IL1B	840	0.26	0.12	YES
7	GRIN2B	GRIN2B	GRIN2B	1270	0.2	0.11	YES
8	MAPT	MAPT	MAPT	1284	0.2	0.13	YES
9	NDUFC1	NDUFC1	NDUFC1	1445	0.18	0.13	YES
10	CALML5	CALML5	CALML5	1446	0.18	0.15	YES
11	GRIN2A	GRIN2A	GRIN2A	1773	0.16	0.14	YES
12	NDUFB1	NDUFB1	NDUFB1	1904	0.14	0.15	YES
13	CASP3	CASP3	CASP3	2083	0.13	0.15	YES
14	BACE2	BACE2	BACE2	2446	0.11	0.14	YES
15	NDUFB5	NDUFB5	NDUFB5	2511	0.11	0.15	YES
16	ITPR3	ITPR3	ITPR3	2616	0.11	0.15	YES
17	ATP2A1	ATP2A1	ATP2A1	2623	0.1	0.16	YES
18	CASP8	CASP8	CASP8	2633	0.1	0.17	YES
19	COX7A1	COX7A1	COX7A1	2793	0.099	0.17	YES
20	CHP2	CHP2	CHP2	2833	0.097	0.17	YES
21	TNF	TNF	TNF	3012	0.09	0.17	YES
22	ATP5G1	ATP5G1	ATP5G1	3037	0.089	0.18	YES
23	ATP5H	ATP5H	ATP5H	3065	0.088	0.18	YES
24	NDUFA2	NDUFA2	NDUFA2	3110	0.087	0.19	YES
25	CASP9	CASP9	CASP9	3126	0.087	0.19	YES
26	TNFRSF1A	TNFRSF1A	TNFRSF1A	3155	0.086	0.2	YES
27	ATP5G3	ATP5G3	ATP5G3	3195	0.085	0.2	YES
28	NDUFA3	NDUFA3	NDUFA3	3388	0.079	0.2	YES
29	NDUFB4	NDUFB4	NDUFB4	3542	0.074	0.2	YES
30	SDHD	SDHD	SDHD	3648	0.071	0.2	YES
31	COX7C	COX7C	COX7C	3775	0.068	0.2	YES
32	UQCR10	UQCR10	UQCR10	3849	0.066	0.2	YES
33	NDUFV3	NDUFV3	NDUFV3	3858	0.065	0.2	YES
34	COX5B	COX5B	COX5B	3887	0.065	0.21	YES
35	FADD	FADD	FADD	3888	0.065	0.21	YES
36	NDUFB6	NDUFB6	NDUFB6	3928	0.064	0.22	YES
37	ATP5F1	ATP5F1	ATP5F1	3954	0.063	0.22	YES
38	COX8C	COX8C	COX8C	3959	0.063	0.23	YES
39	NDUFA7	NDUFA7	NDUFA7	4063	0.06	0.22	YES
40	NDUFS8	NDUFS8	NDUFS8	4173	0.058	0.22	YES
41	NDUFS4	NDUFS4	NDUFS4	4238	0.057	0.22	YES
42	ATP5A1	ATP5A1	ATP5A1	4243	0.057	0.23	YES
43	UQCRFS1	UQCRFS1	UQCRFS1	4264	0.056	0.23	YES
44	MAPK3	MAPK3	MAPK3	4374	0.053	0.23	YES
45	ATP5C1	ATP5C1	ATP5C1	4425	0.052	0.23	YES
46	COX6A1	COX6A1	COX6A1	4499	0.05	0.23	YES
47	ATP5B	ATP5B	ATP5B	4525	0.05	0.24	YES
48	PSEN1	PSEN1	PSEN1	4547	0.049	0.24	YES
49	BAD	BAD	BAD	4577	0.049	0.24	YES
50	PSEN2	PSEN2	PSEN2	4673	0.046	0.24	YES
51	NAE1	NAE1	NAE1	4759	0.045	0.24	YES
52	UQCRB	UQCRB	UQCRB	4795	0.044	0.24	YES
53	COX7B	COX7B	COX7B	4924	0.042	0.24	YES
54	NDUFV1	NDUFV1	NDUFV1	4942	0.042	0.24	YES
55	ATP5G2	ATP5G2	ATP5G2	4991	0.041	0.24	YES
56	NDUFA10	NDUFA10	NDUFA10	5054	0.039	0.24	YES
57	NDUFB3	NDUFB3	NDUFB3	5069	0.039	0.24	YES
58	UQCRQ	UQCRQ	UQCRQ	5117	0.038	0.24	YES
59	ATP5O	ATP5O	ATP5O	5140	0.038	0.25	YES
60	NDUFS5	NDUFS5	NDUFS5	5153	0.038	0.25	YES
61	PPP3CA	PPP3CA	PPP3CA	5327	0.035	0.24	YES
62	NDUFA9	NDUFA9	NDUFA9	5377	0.034	0.24	YES
63	CAPN2	CAPN2	CAPN2	5380	0.034	0.25	YES
64	COX4I1	COX4I1	COX4I1	5403	0.034	0.25	YES
65	NDUFB10	NDUFB10	NDUFB10	5417	0.033	0.25	YES
66	CAPN1	CAPN1	CAPN1	5429	0.033	0.25	YES
67	APH1A	APH1A	APH1A	5433	0.033	0.25	YES
68	ADAM10	ADAM10	ADAM10	5478	0.032	0.26	YES
69	APP	APP	APP	5493	0.032	0.26	YES
70	NDUFB7	NDUFB7	NDUFB7	5512	0.032	0.26	YES
71	NDUFA8	NDUFA8	NDUFA8	5541	0.031	0.26	YES
72	UQCR11	UQCR11	UQCR11	5567	0.031	0.26	YES
73	GSK3B	GSK3B	GSK3B	5571	0.03	0.26	YES
74	PSENEN	PSENEN	PSENEN	5592	0.03	0.26	YES
75	CALML3	CALML3	CALML3	5684	0.029	0.26	YES
76	APOE	APOE	APOE	5708	0.028	0.26	YES
77	UQCRC2	UQCRC2	UQCRC2	5771	0.027	0.26	YES
78	COX8A	COX8A	COX8A	5813	0.026	0.26	YES
79	NDUFS3	NDUFS3	NDUFS3	5823	0.026	0.26	YES
80	COX6C	COX6C	COX6C	5847	0.026	0.26	YES
81	ATP5J	ATP5J	ATP5J	5874	0.025	0.26	YES
82	COX7A2L	COX7A2L	COX7A2L	5938	0.025	0.26	NO
83	SDHA	SDHA	SDHA	6020	0.024	0.26	NO
84	NDUFB2	NDUFB2	NDUFB2	6048	0.023	0.26	NO
85	NDUFB8	NDUFB8	NDUFB8	6149	0.022	0.26	NO
86	NDUFS1	NDUFS1	NDUFS1	6173	0.021	0.26	NO
87	SDHB	SDHB	SDHB	6182	0.021	0.26	NO
88	NDUFV2	NDUFV2	NDUFV2	6475	0.017	0.24	NO
89	NDUFA1	NDUFA1	NDUFA1	6557	0.016	0.24	NO
90	CYCS	CYCS	CYCS	6572	0.015	0.24	NO
91	NDUFS2	NDUFS2	NDUFS2	6601	0.015	0.24	NO
92	BID	BID	BID	6660	0.014	0.24	NO
93	FAS	FAS	FAS	6713	0.013	0.24	NO
94	EIF2AK3	EIF2AK3	EIF2AK3	6774	0.012	0.24	NO
95	ITPR1	ITPR1	ITPR1	6900	0.011	0.23	NO
96	LRP1	LRP1	LRP1	6919	0.01	0.23	NO
97	NDUFC2	NDUFC2	NDUFC2	6933	0.01	0.23	NO
98	PLCB2	PLCB2	PLCB2	6968	0.0097	0.23	NO
99	NDUFA4	NDUFA4	NDUFA4	6988	0.0095	0.23	NO
100	ATP5E	ATP5E	ATP5E	7044	0.0088	0.23	NO
101	CALM2	CALM2	CALM2	7182	0.007	0.22	NO
102	CYC1	CYC1	CYC1	7207	0.0068	0.22	NO
103	PPP3CC	PPP3CC	PPP3CC	7313	0.0054	0.21	NO
104	ATP5D	ATP5D	ATP5D	7433	0.0036	0.21	NO
105	NDUFS7	NDUFS7	NDUFS7	7585	0.0015	0.2	NO
106	NDUFA5	NDUFA5	NDUFA5	7606	0.0012	0.2	NO
107	UQCRHL	UQCRHL	UQCRHL	7725	-0.00062	0.19	NO
108	UQCRH	UQCRH	UQCRH	7834	-0.0021	0.19	NO
109	COX7A2	COX7A2	COX7A2	7866	-0.0025	0.18	NO
110	CALM3	CALM3	CALM3	7942	-0.0038	0.18	NO
111	COX5A	COX5A	COX5A	8017	-0.0048	0.18	NO
112	HSD17B10	HSD17B10	HSD17B10	8053	-0.0054	0.18	NO
113	CASP7	CASP7	CASP7	8055	-0.0054	0.18	NO
114	NCSTN	NCSTN	NCSTN	8163	-0.0067	0.17	NO
115	SDHC	SDHC	SDHC	8170	-0.0068	0.17	NO
116	NDUFAB1	NDUFAB1	NDUFAB1	8329	-0.0094	0.16	NO
117	COX6B1	COX6B1	COX6B1	8469	-0.011	0.16	NO
118	NDUFS6	NDUFS6	NDUFS6	8569	-0.013	0.15	NO
119	NDUFB9	NDUFB9	NDUFB9	8587	-0.013	0.15	NO
120	GNAQ	GNAQ	GNAQ	8717	-0.015	0.15	NO
121	ITPR2	ITPR2	ITPR2	8719	-0.015	0.15	NO
122	MAPK1	MAPK1	MAPK1	8903	-0.018	0.14	NO
123	CALM1	CALM1	CALM1	9026	-0.02	0.13	NO
124	CDK5	CDK5	CDK5	9311	-0.024	0.12	NO
125	PPP3CB	PPP3CB	PPP3CB	9558	-0.028	0.11	NO
126	PPP3R1	PPP3R1	PPP3R1	9759	-0.032	0.1	NO
127	ATP2A2	ATP2A2	ATP2A2	9836	-0.033	0.098	NO
128	GAPDH	GAPDH	GAPDH	10062	-0.036	0.089	NO
129	GRIN2C	GRIN2C	GRIN2C	10101	-0.037	0.09	NO
130	BACE1	BACE1	BACE1	10232	-0.039	0.086	NO
131	NDUFA6	NDUFA6	NDUFA6	10364	-0.042	0.082	NO
132	UQCRC1	UQCRC1	UQCRC1	10462	-0.043	0.081	NO
133	PLCB3	PLCB3	PLCB3	10753	-0.049	0.069	NO
134	CALML6	CALML6	CALML6	10930	-0.052	0.064	NO
135	ADAM17	ADAM17	ADAM17	11293	-0.061	0.049	NO
136	NDUFA4L2	NDUFA4L2	NDUFA4L2	11319	-0.062	0.053	NO
137	ATF6	ATF6	ATF6	11339	-0.062	0.057	NO
138	ATP2A3	ATP2A3	ATP2A3	11949	-0.076	0.03	NO
139	IDE	IDE	IDE	12068	-0.079	0.03	NO
140	LPL	LPL	LPL	12988	-0.11	-0.012	NO
141	APAF1	APAF1	APAF1	13002	-0.11	-0.0038	NO
142	CACNA1D	CACNA1D	CACNA1D	13336	-0.12	-0.012	NO
143	GRIN1	GRIN1	GRIN1	13485	-0.12	-0.0098	NO
144	APBB1	APBB1	APBB1	13504	-0.12	-9e-05	NO
145	COX6A2	COX6A2	COX6A2	14495	-0.16	-0.041	NO
146	COX6B2	COX6B2	COX6B2	15122	-0.2	-0.058	NO
147	CACNA1C	CACNA1C	CACNA1C	15563	-0.23	-0.063	NO
148	CDK5R1	CDK5R1	CDK5R1	15583	-0.23	-0.045	NO
149	COX4I2	COX4I2	COX4I2	15785	-0.24	-0.035	NO
150	CACNA1S	CACNA1S	CACNA1S	15974	-0.26	-0.024	NO
151	MME	MME	MME	17062	-0.36	-0.054	NO
152	PLCB4	PLCB4	PLCB4	17326	-0.39	-0.035	NO
153	GRIN2D	GRIN2D	GRIN2D	17395	-0.4	-0.0044	NO
154	RYR3	RYR3	RYR3	18001	-0.57	0.01	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA CHREBP2 PATHWAY	40	genes.ES.table	0.32	1.2	0.24	1	1	0.12	0.1	0.11	0.99	0.49
BIOCARTA RHO PATHWAY	31	genes.ES.table	0.4	1.5	0.055	0.51	0.88	0.097	0.079	0.089	0.37	0.14
KEGG GLYCOLYSIS GLUCONEOGENESIS	55	genes.ES.table	0.41	1.3	0.12	0.77	0.98	0.46	0.33	0.3	0.64	0.25
KEGG CITRATE CYCLE TCA CYCLE	29	genes.ES.table	0.39	1.3	0.17	0.83	0.98	0.69	0.42	0.4	0.69	0.29
KEGG STEROID HORMONE BIOSYNTHESIS	39	genes.ES.table	0.5	1.2	0.17	1	1	0.54	0.2	0.43	0.96	0.47
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION	42	genes.ES.table	0.47	1.6	0.065	0.85	0.67	0.45	0.29	0.32	0.53	0.29
KEGG ARGININE AND PROLINE METABOLISM	51	genes.ES.table	0.36	1.2	0.21	1	1	0.26	0.16	0.21	0.94	0.46
KEGG HISTIDINE METABOLISM	28	genes.ES.table	0.62	1.6	0.012	1	0.67	0.54	0.25	0.4	1	0.52
KEGG TYROSINE METABOLISM	40	genes.ES.table	0.44	1.2	0.2	1	1	0.22	0.11	0.2	0.94	0.46
KEGG TRYPTOPHAN METABOLISM	37	genes.ES.table	0.43	1.2	0.26	1	1	0.14	0.052	0.13	0.93	0.44

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAOA	MAOA	MAOA	26	0.71	0.18	YES
2	MAOB	MAOB	MAOB	159	0.53	0.3	YES
3	ALDH1A3	ALDH1A3	ALDH1A3	508	0.38	0.38	YES
4	ALDH3A1	ALDH3A1	ALDH3A1	515	0.37	0.47	YES
5	FTCD	FTCD	FTCD	902	0.3	0.52	YES
6	HEMK1	HEMK1	HEMK1	1925	0.19	0.52	YES
7	AMDHD1	AMDHD1	AMDHD1	2301	0.17	0.54	YES
8	HAL	HAL	HAL	2814	0.14	0.54	YES
9	HNMT	HNMT	HNMT	2940	0.13	0.57	YES
10	ALDH1B1	ALDH1B1	ALDH1B1	3282	0.12	0.58	YES
11	LCMT1	LCMT1	LCMT1	3782	0.1	0.58	YES
12	ALDH3B1	ALDH3B1	ALDH3B1	4116	0.091	0.58	YES
13	TRMT11	TRMT11	TRMT11	4186	0.09	0.6	YES
14	WBSCR22	WBSCR22	WBSCR22	4415	0.083	0.61	YES
15	ALDH7A1	ALDH7A1	ALDH7A1	4559	0.08	0.62	YES
16	METTL2B	METTL2B	METTL2B	6152	0.048	0.55	NO
17	ALDH3A2	ALDH3A2	ALDH3A2	6741	0.039	0.52	NO
18	ALDH9A1	ALDH9A1	ALDH9A1	7049	0.034	0.52	NO
19	ALDH2	ALDH2	ALDH2	7424	0.029	0.5	NO
20	ALDH3B2	ALDH3B2	ALDH3B2	8236	0.018	0.46	NO
21	DDC	DDC	DDC	8777	0.011	0.44	NO
22	UROC1	UROC1	UROC1	10109	-0.0062	0.36	NO
23	HDC	HDC	HDC	10263	-0.008	0.36	NO
24	LCMT2	LCMT2	LCMT2	11004	-0.017	0.32	NO
25	METTL6	METTL6	METTL6	13187	-0.052	0.22	NO
26	ACY3	ACY3	ACY3	13489	-0.058	0.21	NO
27	ABP1	ABP1	ABP1	14377	-0.081	0.18	NO
28	ASPA	ASPA	ASPA	14986	-0.1	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AOX1	AOX1	AOX1	73	0.62	0.14	YES
2	EHHADH	EHHADH	EHHADH	322	0.45	0.23	YES
3	AUH	AUH	AUH	1123	0.27	0.25	YES
4	ACADSB	ACADSB	ACADSB	1313	0.25	0.29	YES
5	BCKDHB	BCKDHB	BCKDHB	1397	0.24	0.34	YES
6	HIBCH	HIBCH	HIBCH	1815	0.2	0.37	YES
7	ACAT1	ACAT1	ACAT1	2961	0.13	0.33	YES
8	PCCA	PCCA	PCCA	3029	0.13	0.36	YES
9	ABAT	ABAT	ABAT	3270	0.12	0.37	YES
10	ALDH1B1	ALDH1B1	ALDH1B1	3282	0.12	0.4	YES
11	MCEE	MCEE	MCEE	3407	0.11	0.42	YES
12	HIBADH	HIBADH	HIBADH	3572	0.11	0.44	YES
13	ACAD8	ACAD8	ACAD8	3665	0.1	0.46	YES
14	OXCT1	OXCT1	OXCT1	4173	0.09	0.45	YES
15	MUT	MUT	MUT	4500	0.081	0.45	YES
16	ALDH7A1	ALDH7A1	ALDH7A1	4559	0.08	0.46	YES
17	HADH	HADH	HADH	4898	0.072	0.46	YES
18	MCCC1	MCCC1	MCCC1	5162	0.067	0.46	YES
19	ACAA2	ACAA2	ACAA2	5261	0.065	0.47	YES
20	DLD	DLD	DLD	5720	0.056	0.46	NO
21	HMGCS1	HMGCS1	HMGCS1	6090	0.049	0.45	NO
22	HSD17B10	HSD17B10	HSD17B10	6093	0.049	0.46	NO
23	MCCC2	MCCC2	MCCC2	6223	0.047	0.47	NO
24	ALDH3A2	ALDH3A2	ALDH3A2	6741	0.039	0.45	NO
25	ALDH9A1	ALDH9A1	ALDH9A1	7049	0.034	0.44	NO
26	DBT	DBT	DBT	7064	0.034	0.44	NO
27	ALDH2	ALDH2	ALDH2	7424	0.029	0.43	NO
28	HMGCL	HMGCL	HMGCL	8346	0.017	0.38	NO
29	BCKDHA	BCKDHA	BCKDHA	8473	0.015	0.38	NO
30	ACAA1	ACAA1	ACAA1	9114	0.0069	0.35	NO
31	ACADM	ACADM	ACADM	9381	0.0034	0.33	NO
32	BCAT2	BCAT2	BCAT2	10413	-0.01	0.28	NO
33	PCCB	PCCB	PCCB	10627	-0.013	0.27	NO
34	HADHB	HADHB	HADHB	10638	-0.013	0.27	NO
35	ALDH6A1	ALDH6A1	ALDH6A1	10738	-0.014	0.27	NO
36	HADHA	HADHA	HADHA	10838	-0.015	0.27	NO
37	ECHS1	ECHS1	ECHS1	11889	-0.029	0.22	NO
38	ACADS	ACADS	ACADS	12479	-0.038	0.19	NO
39	IL4I1	IL4I1	IL4I1	13313	-0.054	0.16	NO
40	IVD	IVD	IVD	14022	-0.071	0.14	NO
41	ACAT2	ACAT2	ACAT2	16370	-0.17	0.048	NO
42	OXCT2	OXCT2	OXCT2	17055	-0.23	0.062	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A9	UGT1A9	UGT1A9	324	0.45	0.083	YES
2	MGAM	MGAM	MGAM	452	0.4	0.16	YES
3	UGT1A1	UGT1A1	UGT1A1	948	0.29	0.2	YES
4	GCK	GCK	GCK	1039	0.28	0.26	YES
5	UGT1A6	UGT1A6	UGT1A6	1082	0.27	0.32	YES
6	AMY2B	AMY2B	AMY2B	1409	0.24	0.36	YES
7	UGT1A10	UGT1A10	UGT1A10	1441	0.23	0.41	YES
8	PYGM	PYGM	PYGM	1458	0.23	0.46	YES
9	GBA3	GBA3	GBA3	1467	0.23	0.51	YES
10	UGT2A1	UGT2A1	UGT2A1	1717	0.21	0.54	YES
11	UGT1A8	UGT1A8	UGT1A8	1787	0.2	0.58	YES
12	ENPP1	ENPP1	ENPP1	2132	0.18	0.6	YES
13	AGL	AGL	AGL	4695	0.077	0.48	NO
14	AMY1A	AMY1A	AMY1A	5201	0.066	0.47	NO
15	GBE1	GBE1	GBE1	5629	0.058	0.46	NO
16	PGM2	PGM2	PGM2	6001	0.05	0.45	NO
17	GPI	GPI	GPI	6764	0.038	0.42	NO
18	UGP2	UGP2	UGP2	7611	0.026	0.37	NO
19	GUSB	GUSB	GUSB	7744	0.025	0.37	NO
20	HK2	HK2	HK2	8708	0.012	0.32	NO
21	AMY2A	AMY2A	AMY2A	9306	0.0043	0.29	NO
22	GAA	GAA	GAA	10438	-0.01	0.23	NO
23	UGDH	UGDH	UGDH	11341	-0.022	0.19	NO
24	PYGB	PYGB	PYGB	11507	-0.024	0.18	NO
25	ENPP3	ENPP3	ENPP3	12329	-0.036	0.14	NO
26	GYS2	GYS2	GYS2	12338	-0.036	0.15	NO
27	PGM1	PGM1	PGM1	13320	-0.054	0.11	NO
28	GYS1	GYS1	GYS1	13365	-0.055	0.12	NO
29	HK1	HK1	HK1	13681	-0.062	0.12	NO
30	PYGL	PYGL	PYGL	13946	-0.069	0.12	NO
31	GANC	GANC	GANC	14660	-0.091	0.099	NO
32	PGM2L1	PGM2L1	PGM2L1	14938	-0.1	0.11	NO
33	TREH	TREH	TREH	16139	-0.16	0.076	NO
34	HK3	HK3	HK3	16274	-0.17	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAOA	MAOA	MAOA	26	0.71	0.072	YES
2	AOX1	AOX1	AOX1	73	0.62	0.13	YES
3	MAOB	MAOB	MAOB	159	0.53	0.18	YES
4	UGT1A9	UGT1A9	UGT1A9	324	0.45	0.22	YES
5	ADH1C	ADH1C	ADH1C	426	0.41	0.26	YES
6	CYP2E1	CYP2E1	CYP2E1	428	0.41	0.3	YES
7	MGST1	MGST1	MGST1	492	0.38	0.33	YES
8	ALDH1A3	ALDH1A3	ALDH1A3	508	0.38	0.37	YES
9	ALDH3A1	ALDH3A1	ALDH3A1	515	0.37	0.41	YES
10	GSTM2	GSTM2	GSTM2	701	0.34	0.43	YES
11	UGT1A1	UGT1A1	UGT1A1	948	0.29	0.45	YES
12	FMO4	FMO4	FMO4	993	0.29	0.48	YES
13	UGT1A6	UGT1A6	UGT1A6	1082	0.27	0.5	YES
14	GSTO2	GSTO2	GSTO2	1134	0.27	0.53	YES
15	CYP2C18	CYP2C18	CYP2C18	1139	0.27	0.55	YES
16	GSTA4	GSTA4	GSTA4	1374	0.24	0.56	YES
17	UGT1A10	UGT1A10	UGT1A10	1441	0.23	0.59	YES
18	GSTM3	GSTM3	GSTM3	1652	0.21	0.6	YES
19	UGT2A1	UGT2A1	UGT2A1	1717	0.21	0.61	YES
20	UGT1A8	UGT1A8	UGT1A8	1787	0.2	0.63	YES
21	GSTM4	GSTM4	GSTM4	1842	0.2	0.65	YES
22	MGST2	MGST2	MGST2	2651	0.15	0.62	NO
23	GSTM1	GSTM1	GSTM1	2833	0.14	0.62	NO
24	CYP3A7	CYP3A7	CYP3A7	2885	0.14	0.63	NO
25	FMO5	FMO5	FMO5	3123	0.12	0.63	NO
26	CYP2C8	CYP2C8	CYP2C8	3306	0.12	0.64	NO
27	CYP2C9	CYP2C9	CYP2C9	3415	0.11	0.64	NO
28	ALDH3B1	ALDH3B1	ALDH3B1	4116	0.091	0.61	NO
29	CYP2A7	CYP2A7	CYP2A7	4154	0.09	0.62	NO
30	FMO1	FMO1	FMO1	4384	0.084	0.62	NO
31	ADH1B	ADH1B	ADH1B	4591	0.079	0.61	NO
32	CYP2A6	CYP2A6	CYP2A6	4650	0.078	0.62	NO
33	MGST3	MGST3	MGST3	4957	0.071	0.61	NO
34	GSTK1	GSTK1	GSTK1	6186	0.048	0.55	NO
35	CYP3A5	CYP3A5	CYP3A5	6222	0.047	0.55	NO
36	GSTP1	GSTP1	GSTP1	6438	0.044	0.54	NO
37	CYP2D6	CYP2D6	CYP2D6	6969	0.035	0.52	NO
38	GSTA1	GSTA1	GSTA1	8026	0.021	0.46	NO
39	ALDH3B2	ALDH3B2	ALDH3B2	8236	0.018	0.45	NO
40	ADH5	ADH5	ADH5	10310	-0.0087	0.34	NO
41	CYP2A13	CYP2A13	CYP2A13	10380	-0.0095	0.33	NO
42	GSTT1	GSTT1	GSTT1	10709	-0.014	0.32	NO
43	GSTO1	GSTO1	GSTO1	10976	-0.017	0.3	NO
44	FMO3	FMO3	FMO3	12007	-0.031	0.25	NO
45	ADH6	ADH6	ADH6	12575	-0.04	0.22	NO
46	GSTT2	GSTT2	GSTT2	12911	-0.046	0.21	NO
47	CYP1A2	CYP1A2	CYP1A2	13263	-0.053	0.2	NO
48	FMO2	FMO2	FMO2	13850	-0.067	0.17	NO
49	CYP3A43	CYP3A43	CYP3A43	13870	-0.067	0.18	NO
50	ADH4	ADH4	ADH4	14516	-0.086	0.15	NO
51	GSTM5	GSTM5	GSTM5	14559	-0.087	0.16	NO
52	GSTA2	GSTA2	GSTA2	15419	-0.12	0.12	NO
53	ADH1A	ADH1A	ADH1A	15697	-0.13	0.12	NO
54	GSTZ1	GSTZ1	GSTZ1	16497	-0.18	0.093	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACSS3	ACSS3	ACSS3	176	0.52	0.16	YES
2	EHHADH	EHHADH	EHHADH	322	0.45	0.3	YES
3	LDHAL6A	LDHAL6A	LDHAL6A	1532	0.22	0.31	YES
4	HIBCH	HIBCH	HIBCH	1815	0.2	0.36	YES
5	ACAT1	ACAT1	ACAT1	2961	0.13	0.34	YES
6	PCCA	PCCA	PCCA	3029	0.13	0.38	YES
7	ABAT	ABAT	ABAT	3270	0.12	0.41	YES
8	ALDH1B1	ALDH1B1	ALDH1B1	3282	0.12	0.45	YES
9	MCEE	MCEE	MCEE	3407	0.11	0.48	YES
10	SUCLA2	SUCLA2	SUCLA2	4235	0.088	0.46	YES
11	MUT	MUT	MUT	4500	0.081	0.48	YES
12	ALDH7A1	ALDH7A1	ALDH7A1	4559	0.08	0.5	YES
13	MLYCD	MLYCD	MLYCD	4675	0.077	0.52	YES
14	ACSS1	ACSS1	ACSS1	5322	0.064	0.51	NO
15	SUCLG2	SUCLG2	SUCLG2	5520	0.06	0.52	NO
16	ACSS2	ACSS2	ACSS2	5900	0.052	0.51	NO
17	ACACA	ACACA	ACACA	6295	0.046	0.5	NO
18	SUCLG1	SUCLG1	SUCLG1	6683	0.04	0.5	NO
19	ALDH3A2	ALDH3A2	ALDH3A2	6741	0.039	0.51	NO
20	LDHA	LDHA	LDHA	6990	0.035	0.5	NO
21	ALDH9A1	ALDH9A1	ALDH9A1	7049	0.034	0.51	NO
22	ALDH2	ALDH2	ALDH2	7424	0.029	0.5	NO
23	LDHB	LDHB	LDHB	9079	0.0072	0.41	NO
24	ACADM	ACADM	ACADM	9381	0.0034	0.4	NO
25	LDHAL6B	LDHAL6B	LDHAL6B	10230	-0.0077	0.35	NO
26	ACACB	ACACB	ACACB	10433	-0.01	0.35	NO
27	PCCB	PCCB	PCCB	10627	-0.013	0.34	NO
28	ALDH6A1	ALDH6A1	ALDH6A1	10738	-0.014	0.34	NO
29	HADHA	HADHA	HADHA	10838	-0.015	0.34	NO
30	ECHS1	ECHS1	ECHS1	11889	-0.029	0.29	NO
31	ACAT2	ACAT2	ACAT2	16370	-0.17	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT1A9	UGT1A9	UGT1A9	324	0.45	0.034	YES
2	CYP2S1	CYP2S1	CYP2S1	377	0.43	0.08	YES
3	ADH1C	ADH1C	ADH1C	426	0.41	0.12	YES
4	CYP2E1	CYP2E1	CYP2E1	428	0.41	0.17	YES
5	MGST1	MGST1	MGST1	492	0.38	0.21	YES
6	ALDH1A3	ALDH1A3	ALDH1A3	508	0.38	0.25	YES
7	ALDH3A1	ALDH3A1	ALDH3A1	515	0.37	0.3	YES
8	AKR1C2	AKR1C2	AKR1C2	686	0.34	0.33	YES
9	GSTM2	GSTM2	GSTM2	701	0.34	0.36	YES
10	UGT1A1	UGT1A1	UGT1A1	948	0.29	0.38	YES
11	UGT1A6	UGT1A6	UGT1A6	1082	0.27	0.41	YES
12	GSTO2	GSTO2	GSTO2	1134	0.27	0.44	YES
13	CYP2C18	CYP2C18	CYP2C18	1139	0.27	0.47	YES
14	GSTA4	GSTA4	GSTA4	1374	0.24	0.48	YES
15	UGT1A10	UGT1A10	UGT1A10	1441	0.23	0.51	YES
16	AKR1C1	AKR1C1	AKR1C1	1563	0.22	0.53	YES
17	GSTM3	GSTM3	GSTM3	1652	0.21	0.55	YES
18	UGT2A1	UGT2A1	UGT2A1	1717	0.21	0.57	YES
19	UGT1A8	UGT1A8	UGT1A8	1787	0.2	0.58	YES
20	GSTM4	GSTM4	GSTM4	1842	0.2	0.6	YES
21	CYP2F1	CYP2F1	CYP2F1	2588	0.15	0.58	YES
22	MGST2	MGST2	MGST2	2651	0.15	0.6	YES
23	GSTM1	GSTM1	GSTM1	2833	0.14	0.6	YES
24	CYP3A7	CYP3A7	CYP3A7	2885	0.14	0.61	YES
25	AKR1C3	AKR1C3	AKR1C3	3170	0.12	0.61	YES
26	CYP2C8	CYP2C8	CYP2C8	3306	0.12	0.62	YES
27	CYP2C9	CYP2C9	CYP2C9	3415	0.11	0.62	YES
28	CYP1B1	CYP1B1	CYP1B1	3660	0.1	0.62	NO
29	EPHX1	EPHX1	EPHX1	4012	0.095	0.62	NO
30	ALDH3B1	ALDH3B1	ALDH3B1	4116	0.091	0.62	NO
31	ADH1B	ADH1B	ADH1B	4591	0.079	0.6	NO
32	MGST3	MGST3	MGST3	4957	0.071	0.59	NO
33	GSTK1	GSTK1	GSTK1	6186	0.048	0.53	NO
34	CYP3A5	CYP3A5	CYP3A5	6222	0.047	0.53	NO
35	GSTP1	GSTP1	GSTP1	6438	0.044	0.53	NO
36	GSTA1	GSTA1	GSTA1	8026	0.021	0.44	NO
37	ALDH3B2	ALDH3B2	ALDH3B2	8236	0.018	0.43	NO
38	CYP1A1	CYP1A1	CYP1A1	8695	0.012	0.41	NO
39	ADH5	ADH5	ADH5	10310	-0.0087	0.32	NO
40	GSTT1	GSTT1	GSTT1	10709	-0.014	0.3	NO
41	GSTO1	GSTO1	GSTO1	10976	-0.017	0.29	NO
42	ADH6	ADH6	ADH6	12575	-0.04	0.2	NO
43	GSTT2	GSTT2	GSTT2	12911	-0.046	0.19	NO
44	CYP1A2	CYP1A2	CYP1A2	13263	-0.053	0.18	NO
45	CYP3A43	CYP3A43	CYP3A43	13870	-0.067	0.15	NO
46	ADH4	ADH4	ADH4	14516	-0.086	0.12	NO
47	GSTM5	GSTM5	GSTM5	14559	-0.087	0.13	NO
48	GSTA2	GSTA2	GSTA2	15419	-0.12	0.099	NO
49	ADH1A	ADH1A	ADH1A	15697	-0.13	0.099	NO
50	DHDH	DHDH	DHDH	16001	-0.15	0.1	NO
51	GSTZ1	GSTZ1	GSTZ1	16497	-0.18	0.093	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ME1	ME1	ME1	864	0.31	0.06	YES
2	PKLR	PKLR	PKLR	1521	0.22	0.1	YES
3	LDHAL6A	LDHAL6A	LDHAL6A	1532	0.22	0.18	YES
4	LDHD	LDHD	LDHD	2668	0.14	0.17	YES
5	ACAT1	ACAT1	ACAT1	2961	0.13	0.2	YES
6	ALDH1B1	ALDH1B1	ALDH1B1	3282	0.12	0.22	YES
7	AKR1B1	AKR1B1	AKR1B1	3473	0.11	0.25	YES
8	HAGHL	HAGHL	HAGHL	3662	0.1	0.28	YES
9	PCK1	PCK1	PCK1	3748	0.1	0.31	YES
10	ME3	ME3	ME3	3837	0.1	0.34	YES
11	ALDH7A1	ALDH7A1	ALDH7A1	4559	0.08	0.33	YES
12	PDHB	PDHB	PDHB	4805	0.074	0.34	YES
13	HAGH	HAGH	HAGH	4886	0.072	0.36	YES
14	PDHA1	PDHA1	PDHA1	5094	0.068	0.38	YES
15	ACSS1	ACSS1	ACSS1	5322	0.064	0.38	YES
16	GLO1	GLO1	GLO1	5538	0.059	0.39	YES
17	DLD	DLD	DLD	5720	0.056	0.4	YES
18	ACSS2	ACSS2	ACSS2	5900	0.052	0.41	YES
19	PC	PC	PC	5909	0.052	0.43	YES
20	ACACA	ACACA	ACACA	6295	0.046	0.42	NO
21	ALDH3A2	ALDH3A2	ALDH3A2	6741	0.039	0.41	NO
22	LDHA	LDHA	LDHA	6990	0.035	0.41	NO
23	ALDH9A1	ALDH9A1	ALDH9A1	7049	0.034	0.42	NO
24	ALDH2	ALDH2	ALDH2	7424	0.029	0.41	NO
25	MDH2	MDH2	MDH2	7509	0.028	0.42	NO
26	MDH1	MDH1	MDH1	7685	0.025	0.42	NO
27	PKM2	PKM2	PKM2	8198	0.019	0.39	NO
28	DLAT	DLAT	DLAT	8334	0.017	0.39	NO
29	LDHB	LDHB	LDHB	9079	0.0072	0.35	NO
30	ME2	ME2	ME2	9146	0.0064	0.35	NO
31	LDHAL6B	LDHAL6B	LDHAL6B	10230	-0.0077	0.3	NO
32	ACACB	ACACB	ACACB	10433	-0.01	0.29	NO
33	GRHPR	GRHPR	GRHPR	11787	-0.028	0.22	NO
34	ACYP2	ACYP2	ACYP2	12370	-0.037	0.2	NO
35	ACYP1	ACYP1	ACYP1	13010	-0.048	0.19	NO
36	PCK2	PCK2	PCK2	15246	-0.11	0.1	NO
37	ACAT2	ACAT2	ACAT2	16370	-0.17	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PPP1R12B	PPP1R12B	PPP1R12B	623	0.35	0.15	YES
2	ARHGAP6	ARHGAP6	ARHGAP6	876	0.31	0.3	YES
3	ARHGEF5	ARHGEF5	ARHGEF5	1430	0.24	0.4	YES
4	MYL2	MYL2	MYL2	4078	0.092	0.3	NO
5	RHOA	RHOA	RHOA	6431	0.044	0.2	NO
6	ARPC1A	ARPC1A	ARPC1A	6786	0.038	0.2	NO
7	PIP5K1A	PIP5K1A	PIP5K1A	6819	0.038	0.22	NO
8	ARPC5	ARPC5	ARPC5	6822	0.038	0.24	NO
9	MYLK	MYLK	MYLK	7341	0.03	0.22	NO
10	ACTR3	ACTR3	ACTR3	8093	0.02	0.19	NO
11	ARHGEF11	ARHGEF11	ARHGEF11	8353	0.017	0.19	NO
12	LIMK1	LIMK1	LIMK1	8445	0.016	0.19	NO
13	ARPC1B	ARPC1B	ARPC1B	8800	0.011	0.18	NO
14	ARPC3	ARPC3	ARPC3	9195	0.0058	0.16	NO
15	PIP5K1B	PIP5K1B	PIP5K1B	9767	-0.0018	0.13	NO
16	ARHGAP4	ARHGAP4	ARHGAP4	9962	-0.0044	0.12	NO
17	OPHN1	OPHN1	OPHN1	10398	-0.0098	0.1	NO
18	BAIAP2	BAIAP2	BAIAP2	10541	-0.012	0.1	NO
19	ACTR2	ACTR2	ACTR2	11116	-0.019	0.08	NO
20	ARHGEF1	ARHGEF1	ARHGEF1	11157	-0.019	0.088	NO
21	DIAPH1	DIAPH1	DIAPH1	11171	-0.02	0.098	NO
22	GSN	GSN	GSN	11473	-0.024	0.094	NO
23	CFL1	CFL1	CFL1	11647	-0.026	0.098	NO
24	ARPC2	ARPC2	ARPC2	11880	-0.029	0.1	NO
25	ARHGAP5	ARHGAP5	ARHGAP5	12596	-0.041	0.083	NO
26	ARHGAP1	ARHGAP1	ARHGAP1	12995	-0.048	0.087	NO
27	ARPC4	ARPC4	ARPC4	13655	-0.062	0.084	NO
28	PFN1	PFN1	PFN1	13808	-0.066	0.11	NO
29	ROCK1	ROCK1	ROCK1	13986	-0.07	0.14	NO
30	VCL	VCL	VCL	14275	-0.078	0.16	NO
31	SRC	SRC	SRC	14758	-0.094	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SNAP25	SNAP25	SNAP25	1124	0.27	0.07	YES
2	STX1B	STX1B	STX1B	1824	0.2	0.13	YES
3	VAMP4	VAMP4	VAMP4	2975	0.13	0.13	YES
4	BET1	BET1	BET1	3218	0.12	0.18	YES
5	STX3	STX3	STX3	3412	0.11	0.22	YES
6	STX2	STX2	STX2	5349	0.064	0.15	YES
7	VAMP7	VAMP7	VAMP7	5559	0.059	0.16	YES
8	VAMP1	VAMP1	VAMP1	5608	0.058	0.19	YES
9	STX7	STX7	STX7	5622	0.058	0.22	YES
10	STX10	STX10	STX10	5783	0.054	0.24	YES
11	VAMP8	VAMP8	VAMP8	6246	0.046	0.23	YES
12	TSNARE1	TSNARE1	TSNARE1	6260	0.046	0.26	YES
13	STX19	STX19	STX19	6261	0.046	0.28	YES
14	STX4	STX4	STX4	6335	0.045	0.3	YES
15	STX8	STX8	STX8	6530	0.042	0.31	YES
16	STX6	STX6	STX6	6550	0.042	0.33	YES
17	BET1L	BET1L	BET1L	6561	0.042	0.35	YES
18	SNAP23	SNAP23	SNAP23	7084	0.034	0.33	YES
19	GOSR1	GOSR1	GOSR1	7148	0.033	0.35	YES
20	USE1	USE1	USE1	7423	0.029	0.35	NO
21	SNAP47	SNAP47	SNAP47	8309	0.017	0.3	NO
22	YKT6	YKT6	YKT6	8808	0.011	0.28	NO
23	STX5	STX5	STX5	9655	-0.00039	0.24	NO
24	STX1A	STX1A	STX1A	9885	-0.0034	0.23	NO
25	SEC22B	SEC22B	SEC22B	9930	-0.0039	0.22	NO
26	STX18	STX18	STX18	10091	-0.0059	0.22	NO
27	VAMP3	VAMP3	VAMP3	10562	-0.012	0.2	NO
28	VAMP2	VAMP2	VAMP2	10571	-0.012	0.2	NO
29	STX16	STX16	STX16	10664	-0.013	0.21	NO
30	STX17	STX17	STX17	10848	-0.015	0.2	NO
31	GOSR2	GOSR2	GOSR2	11005	-0.017	0.2	NO
32	STX12	STX12	STX12	11605	-0.025	0.18	NO
33	BNIP1	BNIP1	BNIP1	13302	-0.054	0.12	NO
34	VTI1A	VTI1A	VTI1A	13525	-0.059	0.13	NO
35	STX11	STX11	STX11	13782	-0.065	0.15	NO
36	VAMP5	VAMP5	VAMP5	14166	-0.075	0.17	NO
37	VTI1B	VTI1B	VTI1B	15259	-0.11	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PSTK	PSTK	PSTK	1600	0.22	-0.0034	YES
2	TARSL2	TARSL2	TARSL2	1742	0.2	0.068	YES
3	CARS2	CARS2	CARS2	1998	0.19	0.13	YES
4	NARS2	NARS2	NARS2	2029	0.18	0.2	YES
5	MARS2	MARS2	MARS2	2427	0.16	0.24	YES
6	EARS2	EARS2	EARS2	2481	0.16	0.29	YES
7	PARS2	PARS2	PARS2	2858	0.14	0.33	YES
8	LARS2	LARS2	LARS2	3101	0.12	0.36	YES
9	IARS2	IARS2	IARS2	4361	0.085	0.32	YES
10	LARS	LARS	LARS	4976	0.071	0.32	YES
11	EPRS	EPRS	EPRS	5434	0.062	0.32	YES
12	RARS2	RARS2	RARS2	5457	0.061	0.34	YES
13	YARS	YARS	YARS	5899	0.052	0.34	YES
14	DARS2	DARS2	DARS2	6146	0.048	0.34	YES
15	QARS	QARS	QARS	6320	0.045	0.35	YES
16	DARS	DARS	DARS	6344	0.045	0.37	YES
17	HARS2	HARS2	HARS2	7003	0.035	0.34	NO
18	FARS2	FARS2	FARS2	7370	0.03	0.33	NO
19	GARS	GARS	GARS	7654	0.026	0.33	NO
20	FARSB	FARSB	FARSB	8053	0.021	0.32	NO
21	WARS2	WARS2	WARS2	8231	0.018	0.31	NO
22	HARS	HARS	HARS	8340	0.017	0.31	NO
23	AARS	AARS	AARS	8369	0.017	0.32	NO
24	MTFMT	MTFMT	MTFMT	8436	0.016	0.32	NO
25	CARS	CARS	CARS	8619	0.013	0.32	NO
26	VARS2	VARS2	VARS2	8645	0.013	0.32	NO
27	NARS	NARS	NARS	8669	0.013	0.32	NO
28	IARS	IARS	IARS	9183	0.006	0.3	NO
29	AARS2	AARS2	AARS2	9319	0.0042	0.29	NO
30	KARS	KARS	KARS	9333	0.004	0.29	NO
31	VARS	VARS	VARS	9908	-0.0036	0.26	NO
32	SEPSECS	SEPSECS	SEPSECS	10045	-0.0054	0.26	NO
33	RARS	RARS	RARS	10205	-0.0074	0.25	NO
34	FARSA	FARSA	FARSA	10522	-0.011	0.24	NO
35	YARS2	YARS2	YARS2	11738	-0.027	0.18	NO
36	TARS	TARS	TARS	12053	-0.032	0.18	NO
37	SARS	SARS	SARS	13036	-0.049	0.14	NO
38	MARS	MARS	MARS	13153	-0.051	0.15	NO
39	SARS2	SARS2	SARS2	15476	-0.12	0.073	NO
40	WARS	WARS	WARS	16710	-0.2	0.081	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA BCR PATHWAY	33	genes.ES.table	0.58	1.6	0.037	0.29	0.66	0.42	0.19	0.34	0.19	0.056
BIOCARTA HIVNEF PATHWAY	57	genes.ES.table	0.39	1.7	0.056	0.46	0.6	0.46	0.3	0.32	0.27	0.15
BIOCARTA IL2RB PATHWAY	37	genes.ES.table	0.57	1.6	0.041	0.25	0.69	0.54	0.28	0.39	0.17	0.036
BIOCARTA RACCYCD PATHWAY	25	genes.ES.table	0.39	1.5	0.054	0.28	0.83	0.44	0.3	0.31	0.2	0.031
BIOCARTA INTEGRIN PATHWAY	37	genes.ES.table	0.46	1.6	0.072	0.28	0.81	0.6	0.33	0.4	0.2	0.03
BIOCARTA TCR PATHWAY	43	genes.ES.table	0.64	1.6	0.031	0.34	0.64	0.3	0.086	0.28	0.22	0.078
BIOCARTA VEGF PATHWAY	28	genes.ES.table	0.57	1.7	0.018	0.89	0.53	0.36	0.19	0.29	0.49	0.32
KEGG PROTEASOME	42	genes.ES.table	0.6	1.6	0.037	0.27	0.69	0.93	0.39	0.56	0.18	0.042
KEGG CHEMOKINE SIGNALING PATHWAY	184	genes.ES.table	0.56	1.6	0.029	0.26	0.73	0.47	0.2	0.38	0.18	0.038
KEGG CELL CYCLE	123	genes.ES.table	0.51	1.6	0.041	0.41	0.62	0.31	0.19	0.25	0.25	0.1

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MECOM	MECOM	MECOM	178	0.53	0.066	YES
2	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.12	YES
3	PIK3R5	PIK3R5	PIK3R5	791	0.36	0.15	YES
4	TGFB1	TGFB1	TGFB1	1801	0.24	0.12	YES
5	SHC3	SHC3	SHC3	1901	0.23	0.15	YES
6	AKT3	AKT3	AKT3	2151	0.21	0.17	YES
7	PIK3R3	PIK3R3	PIK3R3	2285	0.2	0.19	YES
8	TGFBR1	TGFBR1	TGFBR1	2700	0.17	0.19	YES
9	E2F3	E2F3	E2F3	2726	0.17	0.21	YES
10	TGFBR2	TGFBR2	TGFBR2	2899	0.16	0.23	YES
11	E2F2	E2F2	E2F2	3056	0.15	0.24	YES
12	NRAS	NRAS	NRAS	3061	0.15	0.26	YES
13	CDKN1A	CDKN1A	CDKN1A	3377	0.13	0.26	YES
14	SHC1	SHC1	SHC1	3482	0.12	0.27	YES
15	MAP2K1	MAP2K1	MAP2K1	3489	0.12	0.29	YES
16	CCND1	CCND1	CCND1	3547	0.12	0.3	YES
17	CBL	CBL	CBL	3760	0.11	0.31	YES
18	GAB2	GAB2	GAB2	3792	0.11	0.32	YES
19	PIK3CD	PIK3CD	PIK3CD	3885	0.11	0.33	YES
20	RUNX1	RUNX1	RUNX1	3987	0.1	0.34	YES
21	CRK	CRK	CRK	4192	0.095	0.35	YES
22	CDK6	CDK6	CDK6	4400	0.088	0.35	YES
23	HDAC1	HDAC1	HDAC1	4514	0.084	0.35	YES
24	CTBP2	CTBP2	CTBP2	4617	0.082	0.36	YES
25	SHC4	SHC4	SHC4	4712	0.079	0.36	YES
26	BCL2L1	BCL2L1	BCL2L1	4783	0.077	0.37	YES
27	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.38	YES
28	GRB2	GRB2	GRB2	5020	0.07	0.38	YES
29	MAPK1	MAPK1	MAPK1	5081	0.068	0.39	YES
30	BRAF	BRAF	BRAF	5082	0.068	0.4	YES
31	AKT1	AKT1	AKT1	5146	0.066	0.4	YES
32	NFKB1	NFKB1	NFKB1	5152	0.066	0.41	YES
33	PTPN11	PTPN11	PTPN11	5248	0.064	0.42	YES
34	CHUK	CHUK	CHUK	5416	0.06	0.42	YES
35	CBLB	CBLB	CBLB	5615	0.055	0.41	YES
36	KRAS	KRAS	KRAS	5788	0.051	0.41	YES
37	CDKN2A	CDKN2A	CDKN2A	5799	0.051	0.42	YES
38	RB1	RB1	RB1	6667	0.034	0.37	NO
39	IKBKG	IKBKG	IKBKG	6928	0.028	0.36	NO
40	RAF1	RAF1	RAF1	7057	0.026	0.36	NO
41	HRAS	HRAS	HRAS	7235	0.023	0.35	NO
42	CDK4	CDK4	CDK4	7329	0.022	0.35	NO
43	HDAC2	HDAC2	HDAC2	7407	0.02	0.35	NO
44	MYC	MYC	MYC	7482	0.019	0.35	NO
45	CRKL	CRKL	CRKL	7525	0.018	0.35	NO
46	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.33	NO
47	RELA	RELA	RELA	7927	0.011	0.33	NO
48	MAP2K2	MAP2K2	MAP2K2	8004	0.0098	0.33	NO
49	STAT5B	STAT5B	STAT5B	8267	0.0056	0.31	NO
50	MDM2	MDM2	MDM2	8504	0.00086	0.3	NO
51	SOS2	SOS2	SOS2	8545	5.2e-06	0.3	NO
52	CDKN1B	CDKN1B	CDKN1B	8995	-0.0075	0.28	NO
53	ARAF	ARAF	ARAF	9112	-0.0094	0.27	NO
54	SMAD3	SMAD3	SMAD3	9521	-0.017	0.25	NO
55	AKT2	AKT2	AKT2	9654	-0.02	0.24	NO
56	CBLC	CBLC	CBLC	9728	-0.021	0.24	NO
57	ABL1	ABL1	ABL1	9849	-0.023	0.24	NO
58	IKBKB	IKBKB	IKBKB	10274	-0.031	0.22	NO
59	CTBP1	CTBP1	CTBP1	10281	-0.031	0.23	NO
60	SMAD4	SMAD4	SMAD4	10390	-0.033	0.22	NO
61	STAT5A	STAT5A	STAT5A	10621	-0.037	0.22	NO
62	TP53	TP53	TP53	10764	-0.04	0.22	NO
63	SOS1	SOS1	SOS1	11394	-0.054	0.19	NO
64	PIK3CB	PIK3CB	PIK3CB	11615	-0.059	0.18	NO
65	PIK3R2	PIK3R2	PIK3R2	12371	-0.078	0.15	NO
66	MAPK3	MAPK3	MAPK3	13360	-0.11	0.12	NO
67	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.12	NO
68	TGFB2	TGFB2	TGFB2	13539	-0.12	0.14	NO
69	BAD	BAD	BAD	13682	-0.12	0.15	NO
70	BCR	BCR	BCR	14164	-0.14	0.14	NO
71	TGFB3	TGFB3	TGFB3	15446	-0.22	0.1	NO
72	SHC2	SHC2	SHC2	16709	-0.34	0.082	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FLT4	FLT4	FLT4	216	0.51	0.12	YES
2	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.21	YES
3	NOS3	NOS3	NOS3	490	0.42	0.32	YES
4	FLT1	FLT1	FLT1	655	0.39	0.4	YES
5	PRKCB	PRKCB	PRKCB	879	0.35	0.48	YES
6	PRKCA	PRKCA	PRKCA	1560	0.26	0.51	YES
7	HIF1A	HIF1A	HIF1A	1589	0.26	0.57	YES
8	EIF2S1	EIF2S1	EIF2S1	2840	0.16	0.54	YES
9	PXN	PXN	PXN	3064	0.15	0.56	YES
10	SHC1	SHC1	SHC1	3482	0.12	0.57	YES
11	EIF2S2	EIF2S2	EIF2S2	4757	0.078	0.52	NO
12	EIF2B2	EIF2B2	EIF2B2	5373	0.061	0.5	NO
13	EIF2B3	EIF2B3	EIF2B3	5575	0.056	0.51	NO
14	EIF2B5	EIF2B5	EIF2B5	6481	0.037	0.47	NO
15	VHL	VHL	VHL	6727	0.032	0.46	NO
16	EIF2B4	EIF2B4	EIF2B4	6889	0.029	0.46	NO
17	EIF1	EIF1	EIF1	7418	0.02	0.44	NO
18	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.41	NO
19	VEGFA	VEGFA	VEGFA	8371	0.0032	0.39	NO
20	ELAVL1	ELAVL1	ELAVL1	9235	-0.012	0.34	NO
21	EIF2S3	EIF2S3	EIF2S3	9315	-0.013	0.34	NO
22	EIF1AX	EIF1AX	EIF1AX	9534	-0.017	0.33	NO
23	PLCG1	PLCG1	PLCG1	9574	-0.018	0.34	NO
24	EIF2B1	EIF2B1	EIF2B1	10801	-0.041	0.28	NO
25	PTK2	PTK2	PTK2	10935	-0.043	0.28	NO
26	ARNT	ARNT	ARNT	12784	-0.09	0.2	NO
27	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.19	NO
28	KDR	KDR	KDR	15985	-0.26	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL12A	IL12A	IL12A	53	0.66	0.049	YES
2	CR1	CR1	CR1	63	0.64	0.099	YES
3	IFNG	IFNG	IFNG	162	0.54	0.14	YES
4	NOS2	NOS2	NOS2	168	0.54	0.18	YES
5	TLR4	TLR4	TLR4	610	0.39	0.19	YES
6	ITGA4	ITGA4	ITGA4	647	0.39	0.21	YES
7	FCGR1A	FCGR1A	FCGR1A	731	0.37	0.24	YES
8	NCF2	NCF2	NCF2	760	0.37	0.27	YES
9	IL12B	IL12B	IL12B	847	0.35	0.29	YES
10	PRKCB	PRKCB	PRKCB	879	0.35	0.32	YES
11	HLA-DQA2	HLA-DQA2	HLA-DQA2	1130	0.31	0.33	YES
12	TNF	TNF	TNF	1134	0.31	0.35	YES
13	HLA-DQA1	HLA-DQA1	HLA-DQA1	1322	0.29	0.36	YES
14	FCGR3B	FCGR3B	FCGR3B	1325	0.29	0.39	YES
15	FCGR3A	FCGR3A	FCGR3A	1326	0.29	0.41	YES
16	NCF1	NCF1	NCF1	1538	0.26	0.42	YES
17	NCF4	NCF4	NCF4	1558	0.26	0.44	YES
18	HLA-DOB	HLA-DOB	HLA-DOB	1653	0.25	0.45	YES
19	HLA-DOA	HLA-DOA	HLA-DOA	1671	0.25	0.47	YES
20	FCGR2A	FCGR2A	FCGR2A	1745	0.24	0.49	YES
21	HLA-DMB	HLA-DMB	HLA-DMB	1769	0.24	0.51	YES
22	TGFB1	TGFB1	TGFB1	1801	0.24	0.52	YES
23	ITGAM	ITGAM	ITGAM	1870	0.23	0.54	YES
24	HLA-DRB5	HLA-DRB5	HLA-DRB5	1942	0.22	0.55	YES
25	ITGB2	ITGB2	ITGB2	1997	0.22	0.56	YES
26	HLA-DQB1	HLA-DQB1	HLA-DQB1	2063	0.21	0.58	YES
27	HLA-DPA1	HLA-DPA1	HLA-DPA1	2242	0.2	0.58	YES
28	HLA-DPB1	HLA-DPB1	HLA-DPB1	2369	0.19	0.59	YES
29	HLA-DMA	HLA-DMA	HLA-DMA	2464	0.18	0.6	YES
30	HLA-DRA	HLA-DRA	HLA-DRA	2585	0.17	0.61	YES
31	HLA-DRB1	HLA-DRB1	HLA-DRB1	2743	0.16	0.61	YES
32	JAK2	JAK2	JAK2	2836	0.16	0.62	YES
33	ITGB1	ITGB1	ITGB1	3078	0.14	0.62	YES
34	NFKBIB	NFKBIB	NFKBIB	3172	0.14	0.63	YES
35	FCGR2C	FCGR2C	FCGR2C	3335	0.13	0.63	YES
36	IL10	IL10	IL10	3497	0.12	0.63	YES
37	CYBA	CYBA	CYBA	3670	0.12	0.63	YES
38	STAT1	STAT1	STAT1	3739	0.11	0.63	YES
39	PTPN6	PTPN6	PTPN6	3947	0.1	0.63	YES
40	MAPK11	MAPK11	MAPK11	3971	0.1	0.64	YES
41	MAPK13	MAPK13	MAPK13	4521	0.084	0.61	NO
42	TLR2	TLR2	TLR2	4579	0.083	0.62	NO
43	TRAF6	TRAF6	TRAF6	4632	0.081	0.62	NO
44	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.61	NO
45	MAPK1	MAPK1	MAPK1	5081	0.068	0.61	NO
46	NFKB1	NFKB1	NFKB1	5152	0.066	0.61	NO
47	IFNGR2	IFNGR2	IFNGR2	5193	0.065	0.61	NO
48	JUN	JUN	JUN	5321	0.062	0.61	NO
49	JAK1	JAK1	JAK1	6146	0.044	0.57	NO
50	MAPK14	MAPK14	MAPK14	6155	0.043	0.57	NO
51	IFNGR1	IFNGR1	IFNGR1	6184	0.043	0.57	NO
52	MYD88	MYD88	MYD88	6339	0.04	0.57	NO
53	MAPK12	MAPK12	MAPK12	7078	0.026	0.53	NO
54	IRAK1	IRAK1	IRAK1	7129	0.025	0.53	NO
55	IL1A	IL1A	IL1A	7776	0.014	0.49	NO
56	RELA	RELA	RELA	7927	0.011	0.48	NO
57	MAP3K7	MAP3K7	MAP3K7	7958	0.011	0.48	NO
58	TAB2	TAB2	TAB2	8204	0.0066	0.47	NO
59	ELK1	ELK1	ELK1	9441	-0.015	0.4	NO
60	MARCKSL1	MARCKSL1	MARCKSL1	9749	-0.021	0.39	NO
61	TAB1	TAB1	TAB1	10012	-0.026	0.38	NO
62	IRAK4	IRAK4	IRAK4	10416	-0.033	0.36	NO
63	FOS	FOS	FOS	10728	-0.039	0.34	NO
64	IL1B	IL1B	IL1B	11062	-0.046	0.33	NO
65	MAPK3	MAPK3	MAPK3	13360	-0.11	0.21	NO
66	TGFB2	TGFB2	TGFB2	13539	-0.12	0.21	NO
67	TGFB3	TGFB3	TGFB3	15446	-0.22	0.12	NO
68	C3	C3	C3	16989	-0.38	0.066	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CSF2RB	CSF2RB	CSF2RB	204	0.52	0.04	YES
2	IRAK2	IRAK2	IRAK2	226	0.5	0.088	YES
3	TNFRSF10C	TNFRSF10C	TNFRSF10C	242	0.5	0.14	YES
4	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.17	YES
5	TNFRSF10A	TNFRSF10A	TNFRSF10A	447	0.43	0.21	YES
6	IL3RA	IL3RA	IL3RA	631	0.39	0.24	YES
7	PIK3R5	PIK3R5	PIK3R5	791	0.36	0.26	YES
8	TNFSF10	TNFSF10	TNFSF10	814	0.36	0.3	YES
9	TNF	TNF	TNF	1134	0.31	0.31	YES
10	TNFRSF10D	TNFRSF10D	TNFRSF10D	1159	0.31	0.34	YES
11	NGF	NGF	NGF	1963	0.22	0.32	YES
12	PRKACB	PRKACB	PRKACB	1970	0.22	0.34	YES
13	PRKAR2A	PRKAR2A	PRKAR2A	2059	0.21	0.36	YES
14	AKT3	AKT3	AKT3	2151	0.21	0.37	YES
15	PIK3R3	PIK3R3	PIK3R3	2285	0.2	0.38	YES
16	NTRK1	NTRK1	NTRK1	2339	0.19	0.4	YES
17	CFLAR	CFLAR	CFLAR	2363	0.19	0.42	YES
18	TNFRSF10B	TNFRSF10B	TNFRSF10B	2649	0.17	0.42	YES
19	MAP3K14	MAP3K14	MAP3K14	2877	0.16	0.42	YES
20	PPP3CC	PPP3CC	PPP3CC	3052	0.15	0.43	YES
21	TRAF2	TRAF2	TRAF2	3102	0.14	0.44	YES
22	CASP7	CASP7	CASP7	3202	0.14	0.45	YES
23	EXOG	EXOG	EXOG	3379	0.13	0.45	YES
24	BID	BID	BID	3524	0.12	0.45	YES
25	PIK3CD	PIK3CD	PIK3CD	3885	0.11	0.44	NO
26	BAX	BAX	BAX	3925	0.1	0.45	NO
27	BCL2	BCL2	BCL2	4509	0.085	0.43	NO
28	CASP3	CASP3	CASP3	4662	0.08	0.43	NO
29	BCL2L1	BCL2L1	BCL2L1	4783	0.077	0.43	NO
30	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.43	NO
31	FAS	FAS	FAS	5116	0.067	0.42	NO
32	AKT1	AKT1	AKT1	5146	0.066	0.43	NO
33	NFKB1	NFKB1	NFKB1	5152	0.066	0.44	NO
34	BIRC3	BIRC3	BIRC3	5206	0.065	0.44	NO
35	CHUK	CHUK	CHUK	5416	0.06	0.43	NO
36	CYCS	CYCS	CYCS	5660	0.054	0.42	NO
37	PPP3R1	PPP3R1	PPP3R1	5824	0.05	0.42	NO
38	APAF1	APAF1	APAF1	6244	0.042	0.4	NO
39	MYD88	MYD88	MYD88	6339	0.04	0.4	NO
40	IKBKG	IKBKG	IKBKG	6928	0.028	0.37	NO
41	IRAK1	IRAK1	IRAK1	7129	0.025	0.36	NO
42	DFFA	DFFA	DFFA	7432	0.02	0.35	NO
43	PRKAR1A	PRKAR1A	PRKAR1A	7467	0.019	0.35	NO
44	IL1A	IL1A	IL1A	7776	0.014	0.33	NO
45	PRKACA	PRKACA	PRKACA	7846	0.012	0.33	NO
46	BIRC2	BIRC2	BIRC2	7896	0.012	0.33	NO
47	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.33	NO
48	RELA	RELA	RELA	7927	0.011	0.33	NO
49	PRKX	PRKX	PRKX	8319	0.0045	0.31	NO
50	ENDOG	ENDOG	ENDOG	8726	-0.0031	0.28	NO
51	CASP8	CASP8	CASP8	8848	-0.0054	0.28	NO
52	RIPK1	RIPK1	RIPK1	9173	-0.01	0.26	NO
53	TRADD	TRADD	TRADD	9419	-0.015	0.25	NO
54	AKT2	AKT2	AKT2	9654	-0.02	0.24	NO
55	AIFM1	AIFM1	AIFM1	9778	-0.022	0.23	NO
56	IL1R1	IL1R1	IL1R1	9863	-0.023	0.23	NO
57	FADD	FADD	FADD	10022	-0.026	0.23	NO
58	XIAP	XIAP	XIAP	10057	-0.027	0.23	NO
59	IKBKB	IKBKB	IKBKB	10274	-0.031	0.22	NO
60	IRAK4	IRAK4	IRAK4	10416	-0.033	0.21	NO
61	TP53	TP53	TP53	10764	-0.04	0.2	NO
62	PPP3CA	PPP3CA	PPP3CA	10887	-0.042	0.2	NO
63	IL1B	IL1B	IL1B	11062	-0.046	0.19	NO
64	TNFRSF1A	TNFRSF1A	TNFRSF1A	11080	-0.046	0.19	NO
65	IRAK3	IRAK3	IRAK3	11429	-0.055	0.18	NO
66	PPP3CB	PPP3CB	PPP3CB	11518	-0.056	0.18	NO
67	DFFB	DFFB	DFFB	11536	-0.057	0.18	NO
68	CAPN2	CAPN2	CAPN2	11548	-0.057	0.19	NO
69	PIK3CB	PIK3CB	PIK3CB	11615	-0.059	0.19	NO
70	PRKAR2B	PRKAR2B	PRKAR2B	11630	-0.059	0.2	NO
71	CAPN1	CAPN1	CAPN1	11794	-0.063	0.2	NO
72	CASP10	CASP10	CASP10	12257	-0.075	0.18	NO
73	IL1RAP	IL1RAP	IL1RAP	12312	-0.077	0.18	NO
74	PIK3R2	PIK3R2	PIK3R2	12371	-0.078	0.19	NO
75	ATM	ATM	ATM	12959	-0.095	0.16	NO
76	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.14	NO
77	BAD	BAD	BAD	13682	-0.12	0.15	NO
78	CASP9	CASP9	CASP9	13740	-0.12	0.16	NO
79	ENDOD1	ENDOD1	ENDOD1	13745	-0.12	0.17	NO
80	CHP	CHP	CHP	14285	-0.15	0.15	NO
81	CHP2	CHP2	CHP2	14696	-0.17	0.14	NO
82	PRKAR1B	PRKAR1B	PRKAR1B	15399	-0.21	0.13	NO
83	CASP6	CASP6	CASP6	16035	-0.27	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TNF	TNF	TNF	1134	0.31	-0.00046	YES
2	LMNB1	LMNB1	LMNB1	2227	0.2	-0.021	YES
3	TRAF1	TRAF1	TRAF1	2277	0.2	0.016	YES
4	ARHGDIB	ARHGDIB	ARHGDIB	2316	0.2	0.052	YES
5	CFLAR	CFLAR	CFLAR	2363	0.19	0.088	YES
6	TNFRSF1B	TNFRSF1B	TNFRSF1B	2384	0.19	0.12	YES
7	MAP3K5	MAP3K5	MAP3K5	2487	0.18	0.15	YES
8	MAPK8	MAPK8	MAPK8	2498	0.18	0.19	YES
9	PRKCD	PRKCD	PRKCD	2608	0.17	0.22	YES
10	MAP3K14	MAP3K14	MAP3K14	2877	0.16	0.23	YES
11	LMNB2	LMNB2	LMNB2	2977	0.15	0.26	YES
12	TRAF2	TRAF2	TRAF2	3102	0.14	0.28	YES
13	CASP7	CASP7	CASP7	3202	0.14	0.3	YES
14	PAK2	PAK2	PAK2	3512	0.12	0.31	YES
15	BID	BID	BID	3524	0.12	0.33	YES
16	BAG4	BAG4	BAG4	3758	0.11	0.34	YES
17	RASA1	RASA1	RASA1	4416	0.088	0.32	YES
18	BCL2	BCL2	BCL2	4509	0.085	0.34	YES
19	CASP3	CASP3	CASP3	4662	0.08	0.34	YES
20	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.34	YES
21	FAS	FAS	FAS	5116	0.067	0.35	YES
22	PSEN1	PSEN1	PSEN1	5147	0.066	0.36	YES
23	NFKB1	NFKB1	NFKB1	5152	0.066	0.37	YES
24	BIRC3	BIRC3	BIRC3	5206	0.065	0.38	YES
25	LMNA	LMNA	LMNA	5367	0.061	0.38	YES
26	CHUK	CHUK	CHUK	5416	0.06	0.39	YES
27	CYCS	CYCS	CYCS	5660	0.054	0.39	NO
28	APAF1	APAF1	APAF1	6244	0.042	0.37	NO
29	PRKDC	PRKDC	PRKDC	6391	0.039	0.37	NO
30	RB1	RB1	RB1	6667	0.034	0.36	NO
31	ACTG1	ACTG1	ACTG1	7414	0.02	0.32	NO
32	DFFA	DFFA	DFFA	7432	0.02	0.32	NO
33	PARP1	PARP1	PARP1	7887	0.012	0.3	NO
34	BIRC2	BIRC2	BIRC2	7896	0.012	0.3	NO
35	RELA	RELA	RELA	7927	0.011	0.3	NO
36	CDK11A	CDK11A	CDK11A	8142	0.0077	0.29	NO
37	MDM2	MDM2	MDM2	8504	0.00086	0.27	NO
38	DAXX	DAXX	DAXX	8702	-0.0026	0.26	NO
39	CASP8	CASP8	CASP8	8848	-0.0054	0.26	NO
40	RIPK1	RIPK1	RIPK1	9173	-0.01	0.24	NO
41	GSN	GSN	GSN	9185	-0.011	0.24	NO
42	CDK11B	CDK11B	CDK11B	9197	-0.011	0.24	NO
43	TRADD	TRADD	TRADD	9419	-0.015	0.23	NO
44	FADD	FADD	FADD	10022	-0.026	0.2	NO
45	XIAP	XIAP	XIAP	10057	-0.027	0.21	NO
46	CASP2	CASP2	CASP2	10377	-0.032	0.2	NO
47	PTK2	PTK2	PTK2	10935	-0.043	0.18	NO
48	TNFRSF1A	TNFRSF1A	TNFRSF1A	11080	-0.046	0.18	NO
49	DFFB	DFFB	DFFB	11536	-0.057	0.16	NO
50	MAP3K1	MAP3K1	MAP3K1	11861	-0.064	0.16	NO
51	MAP2K7	MAP2K7	MAP2K7	12245	-0.075	0.15	NO
52	SPTAN1	SPTAN1	SPTAN1	12348	-0.078	0.16	NO
53	CRADD	CRADD	CRADD	13692	-0.12	0.11	NO
54	CASP9	CASP9	CASP9	13740	-0.12	0.13	NO
55	PSEN2	PSEN2	PSEN2	14264	-0.14	0.13	NO
56	NUMA1	NUMA1	NUMA1	14423	-0.15	0.15	NO
57	CASP6	CASP6	CASP6	16035	-0.27	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDC25A	CDC25A	CDC25A	396	0.45	0.0081	YES
2	ORC1L	ORC1L	ORC1L	437	0.44	0.035	YES
3	TTK	TTK	TTK	472	0.43	0.062	YES
4	CDC45	CDC45	CDC45	475	0.43	0.09	YES
5	CDC20	CDC20	CDC20	568	0.4	0.11	YES
6	BUB1	BUB1	BUB1	594	0.4	0.14	YES
7	CCNE2	CCNE2	CCNE2	758	0.37	0.15	YES
8	ESPL1	ESPL1	ESPL1	759	0.37	0.18	YES
9	PKMYT1	PKMYT1	PKMYT1	779	0.36	0.2	YES
10	CCNA2	CCNA2	CCNA2	898	0.34	0.22	YES
11	CDC25C	CDC25C	CDC25C	902	0.34	0.24	YES
12	CCNE1	CCNE1	CCNE1	931	0.34	0.26	YES
13	PLK1	PLK1	PLK1	941	0.34	0.28	YES
14	RBL1	RBL1	RBL1	1165	0.31	0.29	YES
15	PTTG1	PTTG1	PTTG1	1213	0.3	0.31	YES
16	GADD45A	GADD45A	GADD45A	1226	0.3	0.33	YES
17	BUB1B	BUB1B	BUB1B	1335	0.29	0.34	YES
18	CDC7	CDC7	CDC7	1428	0.28	0.36	YES
19	CCNB1	CCNB1	CCNB1	1488	0.27	0.37	YES
20	CDC6	CDC6	CDC6	1537	0.26	0.39	YES
21	CDK1	CDK1	CDK1	1581	0.26	0.4	YES
22	ORC6L	ORC6L	ORC6L	1681	0.25	0.41	YES
23	TGFB1	TGFB1	TGFB1	1801	0.24	0.42	YES
24	PTTG2	PTTG2	PTTG2	1876	0.23	0.44	YES
25	CDC14A	CDC14A	CDC14A	1928	0.22	0.45	YES
26	MAD2L1	MAD2L1	MAD2L1	2032	0.22	0.46	YES
27	CHEK1	CHEK1	CHEK1	2069	0.21	0.47	YES
28	CCNB2	CCNB2	CCNB2	2466	0.18	0.46	YES
29	MCM5	MCM5	MCM5	2673	0.17	0.46	YES
30	E2F3	E2F3	E2F3	2726	0.17	0.47	YES
31	GADD45G	GADD45G	GADD45G	2806	0.16	0.47	YES
32	PCNA	PCNA	PCNA	2862	0.16	0.48	YES
33	E2F2	E2F2	E2F2	3056	0.15	0.48	YES
34	CDKN2D	CDKN2D	CDKN2D	3085	0.14	0.49	YES
35	MCM4	MCM4	MCM4	3194	0.14	0.49	YES
36	BUB3	BUB3	BUB3	3228	0.14	0.5	YES
37	WEE1	WEE1	WEE1	3332	0.13	0.5	YES
38	CDKN1A	CDKN1A	CDKN1A	3377	0.13	0.51	YES
39	CCND1	CCND1	CCND1	3547	0.12	0.51	NO
40	YWHAH	YWHAH	YWHAH	3785	0.11	0.5	NO
41	E2F1	E2F1	E2F1	3942	0.1	0.5	NO
42	GADD45B	GADD45B	GADD45B	4005	0.1	0.5	NO
43	CDK2	CDK2	CDK2	4145	0.096	0.5	NO
44	CHEK2	CHEK2	CHEK2	4308	0.091	0.5	NO
45	MAD2L2	MAD2L2	MAD2L2	4330	0.09	0.5	NO
46	CDK6	CDK6	CDK6	4400	0.088	0.51	NO
47	HDAC1	HDAC1	HDAC1	4514	0.084	0.51	NO
48	CDC27	CDC27	CDC27	4642	0.081	0.5	NO
49	MCM7	MCM7	MCM7	5090	0.068	0.48	NO
50	SMC1A	SMC1A	SMC1A	5150	0.066	0.48	NO
51	SMC3	SMC3	SMC3	5178	0.065	0.49	NO
52	CDC23	CDC23	CDC23	5203	0.065	0.49	NO
53	YWHAQ	YWHAQ	YWHAQ	5253	0.064	0.49	NO
54	CDC25B	CDC25B	CDC25B	5425	0.06	0.49	NO
55	RBX1	RBX1	RBX1	5485	0.058	0.49	NO
56	MCM2	MCM2	MCM2	5489	0.058	0.49	NO
57	YWHAG	YWHAG	YWHAG	5597	0.056	0.49	NO
58	CDK7	CDK7	CDK7	5649	0.055	0.49	NO
59	CDKN2A	CDKN2A	CDKN2A	5799	0.051	0.49	NO
60	YWHAB	YWHAB	YWHAB	5922	0.048	0.48	NO
61	YWHAZ	YWHAZ	YWHAZ	6106	0.044	0.48	NO
62	MCM6	MCM6	MCM6	6255	0.042	0.47	NO
63	MCM3	MCM3	MCM3	6353	0.04	0.47	NO
64	PRKDC	PRKDC	PRKDC	6391	0.039	0.47	NO
65	FZR1	FZR1	FZR1	6534	0.036	0.46	NO
66	ANAPC7	ANAPC7	ANAPC7	6579	0.035	0.46	NO
67	E2F4	E2F4	E2F4	6598	0.035	0.46	NO
68	RB1	RB1	RB1	6667	0.034	0.46	NO
69	TFDP1	TFDP1	TFDP1	6784	0.031	0.46	NO
70	ANAPC10	ANAPC10	ANAPC10	6959	0.028	0.45	NO
71	CCND3	CCND3	CCND3	6969	0.028	0.45	NO
72	SKP2	SKP2	SKP2	7008	0.027	0.45	NO
73	ANAPC1	ANAPC1	ANAPC1	7149	0.024	0.44	NO
74	CCNA1	CCNA1	CCNA1	7284	0.022	0.44	NO
75	CDK4	CDK4	CDK4	7329	0.022	0.44	NO
76	HDAC2	HDAC2	HDAC2	7407	0.02	0.44	NO
77	MYC	MYC	MYC	7482	0.019	0.43	NO
78	CDC26	CDC26	CDC26	7555	0.017	0.43	NO
79	MAD1L1	MAD1L1	MAD1L1	7748	0.014	0.42	NO
80	CDC14B	CDC14B	CDC14B	7751	0.014	0.42	NO
81	SMAD2	SMAD2	SMAD2	7798	0.013	0.42	NO
82	CCNH	CCNH	CCNH	7851	0.012	0.42	NO
83	CUL1	CUL1	CUL1	7972	0.01	0.41	NO
84	ZBTB17	ZBTB17	ZBTB17	8084	0.0086	0.4	NO
85	EP300	EP300	EP300	8100	0.0084	0.4	NO
86	YWHAE	YWHAE	YWHAE	8279	0.0052	0.4	NO
87	ORC3L	ORC3L	ORC3L	8407	0.0028	0.39	NO
88	GSK3B	GSK3B	GSK3B	8476	0.0014	0.38	NO
89	MDM2	MDM2	MDM2	8504	0.00086	0.38	NO
90	ORC5L	ORC5L	ORC5L	8591	-0.00071	0.38	NO
91	CDKN1B	CDKN1B	CDKN1B	8995	-0.0075	0.36	NO
92	STAG1	STAG1	STAG1	9150	-0.01	0.35	NO
93	ANAPC11	ANAPC11	ANAPC11	9155	-0.01	0.35	NO
94	RAD21	RAD21	RAD21	9220	-0.012	0.35	NO
95	SMAD3	SMAD3	SMAD3	9521	-0.017	0.33	NO
96	SFN	SFN	SFN	9836	-0.023	0.32	NO
97	ABL1	ABL1	ABL1	9849	-0.023	0.32	NO
98	CDKN2C	CDKN2C	CDKN2C	10011	-0.026	0.31	NO
99	ANAPC2	ANAPC2	ANAPC2	10302	-0.031	0.3	NO
100	SMAD4	SMAD4	SMAD4	10390	-0.033	0.29	NO
101	ANAPC5	ANAPC5	ANAPC5	10514	-0.035	0.29	NO
102	CDKN1C	CDKN1C	CDKN1C	10549	-0.036	0.29	NO
103	ATR	ATR	ATR	10650	-0.038	0.29	NO
104	TP53	TP53	TP53	10764	-0.04	0.28	NO
105	ORC2L	ORC2L	ORC2L	10879	-0.042	0.28	NO
106	SKP1	SKP1	SKP1	10893	-0.042	0.28	NO
107	ANAPC13	ANAPC13	ANAPC13	11199	-0.049	0.27	NO
108	STAG2	STAG2	STAG2	11255	-0.05	0.27	NO
109	ANAPC4	ANAPC4	ANAPC4	11458	-0.055	0.26	NO
110	CREBBP	CREBBP	CREBBP	11686	-0.06	0.25	NO
111	WEE2	WEE2	WEE2	11813	-0.064	0.25	NO
112	RBL2	RBL2	RBL2	11828	-0.064	0.25	NO
113	CDKN2B	CDKN2B	CDKN2B	12416	-0.08	0.22	NO
114	CDC16	CDC16	CDC16	12473	-0.081	0.23	NO
115	ATM	ATM	ATM	12959	-0.095	0.21	NO
116	E2F5	E2F5	E2F5	13056	-0.099	0.21	NO
117	SMC1B	SMC1B	SMC1B	13092	-0.1	0.21	NO
118	ORC4L	ORC4L	ORC4L	13351	-0.11	0.21	NO
119	TGFB2	TGFB2	TGFB2	13539	-0.12	0.2	NO
120	TFDP2	TFDP2	TFDP2	14292	-0.15	0.17	NO
121	CCNB3	CCNB3	CCNB3	15346	-0.21	0.13	NO
122	TGFB3	TGFB3	TGFB3	15446	-0.22	0.14	NO
123	CCND2	CCND2	CCND2	15513	-0.22	0.15	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL12A	IL12A	IL12A	53	0.66	0.048	YES
2	CD80	CD80	CD80	64	0.64	0.096	YES
3	TLR8	TLR8	TLR8	118	0.57	0.14	YES
4	CXCL9	CXCL9	CXCL9	344	0.46	0.16	YES
5	CCL4	CCL4	CCL4	395	0.45	0.19	YES
6	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.22	YES
7	CXCL10	CXCL10	CXCL10	441	0.44	0.26	YES
8	TLR4	TLR4	TLR4	610	0.39	0.28	YES
9	CCL5	CCL5	CCL5	719	0.37	0.3	YES
10	PIK3R5	PIK3R5	PIK3R5	791	0.36	0.32	YES
11	IL6	IL6	IL6	834	0.36	0.35	YES
12	IL12B	IL12B	IL12B	847	0.35	0.38	YES
13	CCL3	CCL3	CCL3	921	0.34	0.4	YES
14	TLR6	TLR6	TLR6	924	0.34	0.42	YES
15	CXCL11	CXCL11	CXCL11	930	0.34	0.45	YES
16	TNF	TNF	TNF	1134	0.31	0.46	YES
17	CD86	CD86	CD86	1273	0.3	0.48	YES
18	TLR1	TLR1	TLR1	1443	0.27	0.49	YES
19	CD40	CD40	CD40	1761	0.24	0.49	YES
20	TICAM2	TICAM2	TICAM2	1985	0.22	0.49	YES
21	TLR7	TLR7	TLR7	2079	0.21	0.51	YES
22	AKT3	AKT3	AKT3	2151	0.21	0.52	YES
23	IL8	IL8	IL8	2185	0.2	0.53	YES
24	TRAF3	TRAF3	TRAF3	2192	0.2	0.55	YES
25	PIK3R3	PIK3R3	PIK3R3	2285	0.2	0.56	YES
26	MAPK8	MAPK8	MAPK8	2498	0.18	0.56	YES
27	MAP2K1	MAP2K1	MAP2K1	3489	0.12	0.51	NO
28	CD14	CD14	CD14	3496	0.12	0.52	NO
29	STAT1	STAT1	STAT1	3739	0.11	0.52	NO
30	PIK3CD	PIK3CD	PIK3CD	3885	0.11	0.52	NO
31	SPP1	SPP1	SPP1	3967	0.1	0.52	NO
32	MAPK11	MAPK11	MAPK11	3971	0.1	0.53	NO
33	IFNB1	IFNB1	IFNB1	4385	0.089	0.51	NO
34	MAPK13	MAPK13	MAPK13	4521	0.084	0.51	NO
35	TLR2	TLR2	TLR2	4579	0.083	0.52	NO
36	TRAF6	TRAF6	TRAF6	4632	0.081	0.52	NO
37	LY96	LY96	LY96	4732	0.078	0.52	NO
38	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.52	NO
39	IRF5	IRF5	IRF5	4963	0.072	0.52	NO
40	MAP2K3	MAP2K3	MAP2K3	4976	0.071	0.52	NO
41	MAPK1	MAPK1	MAPK1	5081	0.068	0.52	NO
42	AKT1	AKT1	AKT1	5146	0.066	0.52	NO
43	NFKB1	NFKB1	NFKB1	5152	0.066	0.53	NO
44	IKBKE	IKBKE	IKBKE	5272	0.063	0.53	NO
45	JUN	JUN	JUN	5321	0.062	0.53	NO
46	CHUK	CHUK	CHUK	5416	0.06	0.53	NO
47	IFNAR2	IFNAR2	IFNAR2	5472	0.059	0.53	NO
48	MAPK9	MAPK9	MAPK9	6030	0.046	0.5	NO
49	MAPK14	MAPK14	MAPK14	6155	0.043	0.5	NO
50	MYD88	MYD88	MYD88	6339	0.04	0.49	NO
51	TICAM1	TICAM1	TICAM1	6364	0.039	0.49	NO
52	IRF3	IRF3	IRF3	6668	0.034	0.48	NO
53	IKBKG	IKBKG	IKBKG	6928	0.028	0.47	NO
54	IRF7	IRF7	IRF7	7039	0.026	0.46	NO
55	MAPK12	MAPK12	MAPK12	7078	0.026	0.46	NO
56	IRAK1	IRAK1	IRAK1	7129	0.025	0.46	NO
57	RAC1	RAC1	RAC1	7823	0.013	0.42	NO
58	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.42	NO
59	RELA	RELA	RELA	7927	0.011	0.42	NO
60	MAP3K7	MAP3K7	MAP3K7	7958	0.011	0.42	NO
61	MAP2K2	MAP2K2	MAP2K2	8004	0.0098	0.42	NO
62	TAB2	TAB2	TAB2	8204	0.0066	0.41	NO
63	LBP	LBP	LBP	8339	0.004	0.4	NO
64	TOLLIP	TOLLIP	TOLLIP	8344	0.0039	0.4	NO
65	CASP8	CASP8	CASP8	8848	-0.0054	0.37	NO
66	RIPK1	RIPK1	RIPK1	9173	-0.01	0.36	NO
67	AKT2	AKT2	AKT2	9654	-0.02	0.33	NO
68	TAB1	TAB1	TAB1	10012	-0.026	0.31	NO
69	IFNAR1	IFNAR1	IFNAR1	10015	-0.026	0.32	NO
70	FADD	FADD	FADD	10022	-0.026	0.32	NO
71	IKBKB	IKBKB	IKBKB	10274	-0.031	0.31	NO
72	IRAK4	IRAK4	IRAK4	10416	-0.033	0.3	NO
73	FOS	FOS	FOS	10728	-0.039	0.29	NO
74	IL1B	IL1B	IL1B	11062	-0.046	0.27	NO
75	TLR9	TLR9	TLR9	11214	-0.049	0.27	NO
76	MAP2K4	MAP2K4	MAP2K4	11219	-0.05	0.27	NO
77	PIK3CB	PIK3CB	PIK3CB	11615	-0.059	0.25	NO
78	MAP2K6	MAP2K6	MAP2K6	11905	-0.065	0.24	NO
79	TLR5	TLR5	TLR5	11955	-0.067	0.24	NO
80	MAP2K7	MAP2K7	MAP2K7	12245	-0.075	0.24	NO
81	MAP3K8	MAP3K8	MAP3K8	12267	-0.075	0.24	NO
82	PIK3R2	PIK3R2	PIK3R2	12371	-0.078	0.24	NO
83	TLR3	TLR3	TLR3	13195	-0.1	0.2	NO
84	MAPK3	MAPK3	MAPK3	13360	-0.11	0.2	NO
85	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.2	NO
86	CTSK	CTSK	CTSK	13822	-0.13	0.2	NO
87	TIRAP	TIRAP	TIRAP	14512	-0.16	0.17	NO
88	MAPK10	MAPK10	MAPK10	17321	-0.44	0.048	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD3G	CD3G	CD3G	193	0.52	0.066	YES
2	LCK	LCK	LCK	284	0.48	0.13	YES
3	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.19	YES
4	CD3D	CD3D	CD3D	449	0.43	0.25	YES
5	CD3E	CD3E	CD3E	530	0.41	0.31	YES
6	CD247	CD247	CD247	606	0.4	0.36	YES
7	LAT	LAT	LAT	636	0.39	0.42	YES
8	ZAP70	ZAP70	ZAP70	813	0.36	0.46	YES
9	PRKCB	PRKCB	PRKCB	879	0.35	0.51	YES
10	PTPN7	PTPN7	PTPN7	1015	0.33	0.55	YES
11	NFATC2	NFATC2	NFATC2	1458	0.27	0.56	YES
12	VAV1	VAV1	VAV1	1471	0.27	0.6	YES
13	PRKCA	PRKCA	PRKCA	1560	0.26	0.64	YES
14	MAPK8	MAPK8	MAPK8	2498	0.18	0.61	NO
15	PPP3CC	PPP3CC	PPP3CC	3052	0.15	0.6	NO
16	SHC1	SHC1	SHC1	3482	0.12	0.6	NO
17	MAP2K1	MAP2K1	MAP2K1	3489	0.12	0.62	NO
18	RASA1	RASA1	RASA1	4416	0.088	0.58	NO
19	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.56	NO
20	GRB2	GRB2	GRB2	5020	0.07	0.57	NO
21	NFKB1	NFKB1	NFKB1	5152	0.066	0.57	NO
22	JUN	JUN	JUN	5321	0.062	0.57	NO
23	CALM1	CALM1	CALM1	5540	0.057	0.57	NO
24	CALM3	CALM3	CALM3	6554	0.036	0.52	NO
25	CALM2	CALM2	CALM2	6654	0.034	0.52	NO
26	RAF1	RAF1	RAF1	7057	0.026	0.5	NO
27	RAC1	RAC1	RAC1	7823	0.013	0.46	NO
28	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.45	NO
29	RELA	RELA	RELA	7927	0.011	0.45	NO
30	ELK1	ELK1	ELK1	9441	-0.015	0.37	NO
31	PLCG1	PLCG1	PLCG1	9574	-0.018	0.37	NO
32	NFATC1	NFATC1	NFATC1	9706	-0.02	0.36	NO
33	FYN	FYN	FYN	10144	-0.028	0.34	NO
34	FOS	FOS	FOS	10728	-0.039	0.32	NO
35	PPP3CA	PPP3CA	PPP3CA	10887	-0.042	0.32	NO
36	MAP2K4	MAP2K4	MAP2K4	11219	-0.05	0.3	NO
37	SOS1	SOS1	SOS1	11394	-0.054	0.3	NO
38	PPP3CB	PPP3CB	PPP3CB	11518	-0.056	0.3	NO
39	NFATC3	NFATC3	NFATC3	11806	-0.063	0.3	NO
40	MAP3K1	MAP3K1	MAP3K1	11861	-0.064	0.3	NO
41	NFATC4	NFATC4	NFATC4	12288	-0.076	0.29	NO
42	MAPK3	MAPK3	MAPK3	13360	-0.11	0.25	NO
43	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.26	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	DAPP1	DAPP1	DAPP1	325	0.47	0.029	YES
2	PIK3CG	PIK3CG	PIK3CG	432	0.44	0.067	YES
3	CD72	CD72	CD72	448	0.43	0.11	YES
4	LILRB3	LILRB3	LILRB3	635	0.39	0.14	YES
5	PIK3R5	PIK3R5	PIK3R5	791	0.36	0.17	YES
6	PRKCB	PRKCB	PRKCB	879	0.35	0.2	YES
7	PIK3AP1	PIK3AP1	PIK3AP1	960	0.34	0.22	YES
8	RASGRP3	RASGRP3	RASGRP3	990	0.33	0.26	YES
9	BTK	BTK	BTK	1384	0.28	0.26	YES
10	NFATC2	NFATC2	NFATC2	1458	0.27	0.29	YES
11	VAV1	VAV1	VAV1	1471	0.27	0.31	YES
12	RAC2	RAC2	RAC2	1481	0.27	0.34	YES
13	CD79B	CD79B	CD79B	1755	0.24	0.35	YES
14	CD19	CD19	CD19	1830	0.23	0.37	YES
15	BCL10	BCL10	BCL10	1914	0.23	0.38	YES
16	AKT3	AKT3	AKT3	2151	0.21	0.39	YES
17	LYN	LYN	LYN	2272	0.2	0.41	YES
18	PIK3R3	PIK3R3	PIK3R3	2285	0.2	0.43	YES
19	SYK	SYK	SYK	2497	0.18	0.43	YES
20	VAV3	VAV3	VAV3	2505	0.18	0.45	YES
21	BLNK	BLNK	BLNK	2539	0.18	0.46	YES
22	NFKBIE	NFKBIE	NFKBIE	2557	0.18	0.48	YES
23	CD79A	CD79A	CD79A	2748	0.16	0.49	YES
24	PPP3CC	PPP3CC	PPP3CC	3052	0.15	0.49	YES
25	NRAS	NRAS	NRAS	3061	0.15	0.5	YES
26	PLCG2	PLCG2	PLCG2	3161	0.14	0.51	YES
27	NFKBIB	NFKBIB	NFKBIB	3172	0.14	0.52	YES
28	CR2	CR2	CR2	3298	0.14	0.53	YES
29	MALT1	MALT1	MALT1	3369	0.13	0.54	YES
30	MAP2K1	MAP2K1	MAP2K1	3489	0.12	0.54	YES
31	FCGR2B	FCGR2B	FCGR2B	3667	0.12	0.55	YES
32	PIK3CD	PIK3CD	PIK3CD	3885	0.11	0.55	YES
33	PTPN6	PTPN6	PTPN6	3947	0.1	0.55	YES
34	RAC3	RAC3	RAC3	4513	0.084	0.53	NO
35	NFKBIA	NFKBIA	NFKBIA	4907	0.073	0.52	NO
36	GRB2	GRB2	GRB2	5020	0.07	0.52	NO
37	MAPK1	MAPK1	MAPK1	5081	0.068	0.52	NO
38	AKT1	AKT1	AKT1	5146	0.066	0.52	NO
39	NFKB1	NFKB1	NFKB1	5152	0.066	0.53	NO
40	JUN	JUN	JUN	5321	0.062	0.53	NO
41	INPP5D	INPP5D	INPP5D	5332	0.062	0.53	NO
42	CHUK	CHUK	CHUK	5416	0.06	0.53	NO
43	KRAS	KRAS	KRAS	5788	0.051	0.52	NO
44	PPP3R1	PPP3R1	PPP3R1	5824	0.05	0.52	NO
45	IKBKG	IKBKG	IKBKG	6928	0.028	0.46	NO
46	RAF1	RAF1	RAF1	7057	0.026	0.46	NO
47	RAC1	RAC1	RAC1	7823	0.013	0.42	NO
48	PIK3CA	PIK3CA	PIK3CA	7906	0.012	0.41	NO
49	RELA	RELA	RELA	7927	0.011	0.41	NO
50	MAP2K2	MAP2K2	MAP2K2	8004	0.0098	0.41	NO
51	GSK3B	GSK3B	GSK3B	8476	0.0014	0.38	NO
52	SOS2	SOS2	SOS2	8545	5.2e-06	0.38	NO
53	VAV2	VAV2	VAV2	8600	-0.00084	0.38	NO
54	AKT2	AKT2	AKT2	9654	-0.02	0.32	NO
55	NFATC1	NFATC1	NFATC1	9706	-0.02	0.32	NO
56	CD81	CD81	CD81	10108	-0.028	0.3	NO
57	IKBKB	IKBKB	IKBKB	10274	-0.031	0.3	NO
58	FOS	FOS	FOS	10728	-0.039	0.27	NO
59	PPP3CA	PPP3CA	PPP3CA	10887	-0.042	0.27	NO
60	NFAT5	NFAT5	NFAT5	10979	-0.044	0.27	NO
61	SOS1	SOS1	SOS1	11394	-0.054	0.25	NO
62	PPP3CB	PPP3CB	PPP3CB	11518	-0.056	0.25	NO
63	PIK3CB	PIK3CB	PIK3CB	11615	-0.059	0.25	NO
64	NFATC3	NFATC3	NFATC3	11806	-0.063	0.25	NO
65	IFITM1	IFITM1	IFITM1	12199	-0.074	0.23	NO
66	NFATC4	NFATC4	NFATC4	12288	-0.076	0.24	NO
67	PIK3R2	PIK3R2	PIK3R2	12371	-0.078	0.24	NO
68	MAPK3	MAPK3	MAPK3	13360	-0.11	0.2	NO
69	PIK3R1	PIK3R1	PIK3R1	13476	-0.11	0.2	NO
70	CARD11	CARD11	CARD11	13932	-0.13	0.19	NO
71	CHP	CHP	CHP	14285	-0.15	0.18	NO
72	CD22	CD22	CD22	14298	-0.15	0.2	NO
73	CHP2	CHP2	CHP2	14696	-0.17	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	879	0.35	0.042	YES
2	BTK	BTK	BTK	1384	0.28	0.086	YES
3	NFATC2	NFATC2	NFATC2	1458	0.27	0.15	YES
4	VAV1	VAV1	VAV1	1471	0.27	0.22	YES
5	PRKCA	PRKCA	PRKCA	1560	0.26	0.28	YES
6	CD79B	CD79B	CD79B	1755	0.24	0.34	YES
7	LYN	LYN	LYN	2272	0.2	0.36	YES
8	SYK	SYK	SYK	2497	0.18	0.39	YES
9	MAPK8	MAPK8	MAPK8	2498	0.18	0.44	YES
10	BLNK	BLNK	BLNK	2539	0.18	0.48	YES
11	CD79A	CD79A	CD79A	2748	0.16	0.51	YES
12	PPP3CC	PPP3CC	PPP3CC	3052	0.15	0.54	YES
13	SHC1	SHC1	SHC1	3482	0.12	0.54	YES
14	MAP2K1	MAP2K1	MAP2K1	3489	0.12	0.58	YES
15	GRB2	GRB2	GRB2	5020	0.07	0.51	NO
16	JUN	JUN	JUN	5321	0.062	0.51	NO
17	CALM1	CALM1	CALM1	5540	0.057	0.51	NO
18	MAPK14	MAPK14	MAPK14	6155	0.043	0.49	NO
19	CALM3	CALM3	CALM3	6554	0.036	0.48	NO
20	CALM2	CALM2	CALM2	6654	0.034	0.48	NO
21	RAF1	RAF1	RAF1	7057	0.026	0.46	NO
22	RAC1	RAC1	RAC1	7823	0.013	0.43	NO
23	ELK1	ELK1	ELK1	9441	-0.015	0.34	NO
24	PLCG1	PLCG1	PLCG1	9574	-0.018	0.34	NO
25	NFATC1	NFATC1	NFATC1	9706	-0.02	0.34	NO
26	FOS	FOS	FOS	10728	-0.039	0.29	NO
27	PPP3CA	PPP3CA	PPP3CA	10887	-0.042	0.29	NO
28	SOS1	SOS1	SOS1	11394	-0.054	0.28	NO
29	PPP3CB	PPP3CB	PPP3CB	11518	-0.056	0.29	NO
30	NFATC3	NFATC3	NFATC3	11806	-0.063	0.29	NO
31	MAP3K1	MAP3K1	MAP3K1	11861	-0.064	0.3	NO
32	NFATC4	NFATC4	NFATC4	12288	-0.076	0.3	NO
33	MAPK3	MAPK3	MAPK3	13360	-0.11	0.27	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA ALK PATHWAY	35	genes.ES.table	0.6	1.7	0.0041	0.54	0.5	0.23	0.078	0.21	0.13	0.18
BIOCARTA G1 PATHWAY	27	genes.ES.table	0.5	1.4	0.13	0.48	0.96	0.44	0.26	0.33	0.38	0.092
BIOCARTA WNT PATHWAY	25	genes.ES.table	0.4	1.4	0.11	0.44	0.94	0.44	0.35	0.29	0.34	0.082
KEGG PURINE METABOLISM	154	genes.ES.table	0.35	1.4	0.046	0.49	0.96	0.18	0.18	0.15	0.39	0.1
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES	25	genes.ES.table	0.52	1.4	0.066	0.49	0.97	0.4	0.17	0.33	0.4	0.096
KEGG CALCIUM SIGNALING PATHWAY	163	genes.ES.table	0.46	1.4	0.057	0.47	0.97	0.36	0.19	0.29	0.38	0.085
KEGG OOCYTE MEIOSIS	105	genes.ES.table	0.45	1.5	0.072	0.37	0.86	0.3	0.25	0.22	0.27	0.074
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	106	genes.ES.table	0.49	1.4	0.069	0.45	0.93	0.29	0.16	0.25	0.35	0.092
KEGG WNT SIGNALING PATHWAY	144	genes.ES.table	0.49	1.6	0.012	0.43	0.62	0.29	0.19	0.24	0.23	0.13
KEGG NOTCH SIGNALING PATHWAY	46	genes.ES.table	0.46	1.6	0.016	0.3	0.72	0.52	0.34	0.34	0.18	0.061

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TGFB2	TGFB2	TGFB2	61	0.67	0.042	YES
2	INHBC	INHBC	INHBC	109	0.61	0.08	YES
3	LEFTY1	LEFTY1	LEFTY1	181	0.56	0.11	YES
4	LEFTY2	LEFTY2	LEFTY2	197	0.55	0.15	YES
5	CHRD	CHRD	CHRD	218	0.54	0.19	YES
6	INHBE	INHBE	INHBE	250	0.53	0.22	YES
7	BMP7	BMP7	BMP7	262	0.52	0.25	YES
8	BMP6	BMP6	BMP6	342	0.49	0.28	YES
9	AMH	AMH	AMH	496	0.45	0.3	YES
10	NODAL	NODAL	NODAL	533	0.44	0.33	YES
11	SMAD6	SMAD6	SMAD6	594	0.42	0.36	YES
12	LTBP1	LTBP1	LTBP1	668	0.41	0.38	YES
13	GDF7	GDF7	GDF7	725	0.4	0.4	YES
14	AMHR2	AMHR2	AMHR2	891	0.37	0.42	YES
15	BMP5	BMP5	BMP5	934	0.36	0.44	YES
16	COMP	COMP	COMP	1111	0.34	0.46	YES
17	BMPR1B	BMPR1B	BMPR1B	1247	0.32	0.47	YES
18	FST	FST	FST	1267	0.31	0.49	YES
19	TGFB3	TGFB3	TGFB3	1428	0.29	0.5	YES
20	BMP8A	BMP8A	BMP8A	1505	0.28	0.52	YES
21	ID3	ID3	ID3	1583	0.28	0.53	YES
22	THBS4	THBS4	THBS4	1741	0.26	0.54	YES
23	ID1	ID1	ID1	1775	0.26	0.55	YES
24	INHBA	INHBA	INHBA	1922	0.25	0.56	YES
25	SMAD7	SMAD7	SMAD7	1942	0.24	0.58	YES
26	PITX2	PITX2	PITX2	2236	0.22	0.58	YES
27	SMAD9	SMAD9	SMAD9	2309	0.22	0.59	YES
28	BMP8B	BMP8B	BMP8B	2342	0.22	0.6	YES
29	GDF6	GDF6	GDF6	2546	0.2	0.6	YES
30	THBS1	THBS1	THBS1	2854	0.18	0.6	NO
31	BMPR2	BMPR2	BMPR2	3455	0.16	0.57	NO
32	ACVRL1	ACVRL1	ACVRL1	3582	0.15	0.58	NO
33	ZFYVE9	ZFYVE9	ZFYVE9	4271	0.12	0.55	NO
34	SMAD3	SMAD3	SMAD3	4307	0.12	0.55	NO
35	RBL1	RBL1	RBL1	4446	0.11	0.55	NO
36	DCN	DCN	DCN	4555	0.11	0.56	NO
37	BMPR1A	BMPR1A	BMPR1A	4624	0.11	0.56	NO
38	CREBBP	CREBBP	CREBBP	4938	0.096	0.55	NO
39	SMAD4	SMAD4	SMAD4	6038	0.069	0.49	NO
40	ACVR2B	ACVR2B	ACVR2B	6193	0.066	0.49	NO
41	TGFB1	TGFB1	TGFB1	6457	0.06	0.48	NO
42	ACVR2A	ACVR2A	ACVR2A	6536	0.058	0.48	NO
43	SMAD5	SMAD5	SMAD5	6651	0.056	0.47	NO
44	ROCK1	ROCK1	ROCK1	6659	0.056	0.48	NO
45	THBS2	THBS2	THBS2	6684	0.055	0.48	NO
46	PPP2R1A	PPP2R1A	PPP2R1A	6744	0.054	0.48	NO
47	TFDP1	TFDP1	TFDP1	6997	0.05	0.47	NO
48	SP1	SP1	SP1	7251	0.045	0.46	NO
49	SMAD2	SMAD2	SMAD2	7317	0.044	0.46	NO
50	BMP4	BMP4	BMP4	7608	0.039	0.44	NO
51	EP300	EP300	EP300	7923	0.034	0.43	NO
52	PPP2CB	PPP2CB	PPP2CB	8467	0.026	0.4	NO
53	ACVR1	ACVR1	ACVR1	8483	0.025	0.4	NO
54	THBS3	THBS3	THBS3	8703	0.022	0.39	NO
55	SMURF1	SMURF1	SMURF1	8920	0.019	0.38	NO
56	CUL1	CUL1	CUL1	9575	0.01	0.34	NO
57	TGFBR1	TGFBR1	TGFBR1	9984	0.0045	0.32	NO
58	MAPK1	MAPK1	MAPK1	10177	0.0018	0.31	NO
59	E2F4	E2F4	E2F4	10345	-0.00034	0.3	NO
60	SMAD1	SMAD1	SMAD1	10672	-0.0048	0.29	NO
61	ZFYVE16	ZFYVE16	ZFYVE16	10851	-0.0073	0.28	NO
62	SMURF2	SMURF2	SMURF2	11342	-0.014	0.25	NO
63	ACVR1C	ACVR1C	ACVR1C	11449	-0.016	0.25	NO
64	SKP1	SKP1	SKP1	12006	-0.024	0.22	NO
65	RBX1	RBX1	RBX1	12016	-0.024	0.22	NO
66	ROCK2	ROCK2	ROCK2	12211	-0.027	0.21	NO
67	ID4	ID4	ID4	12277	-0.028	0.21	NO
68	PPP2R1B	PPP2R1B	PPP2R1B	12936	-0.039	0.17	NO
69	TGFBR2	TGFBR2	TGFBR2	12989	-0.04	0.17	NO
70	RHOA	RHOA	RHOA	13234	-0.044	0.16	NO
71	RPS6KB2	RPS6KB2	RPS6KB2	13342	-0.046	0.16	NO
72	PPP2CA	PPP2CA	PPP2CA	13349	-0.046	0.16	NO
73	RPS6KB1	RPS6KB1	RPS6KB1	13650	-0.052	0.15	NO
74	MAPK3	MAPK3	MAPK3	13791	-0.055	0.15	NO
75	E2F5	E2F5	E2F5	13837	-0.056	0.15	NO
76	RBL2	RBL2	RBL2	14070	-0.06	0.14	NO
77	BMP2	BMP2	BMP2	15717	-0.11	0.054	NO
78	INHBB	INHBB	INHBB	15798	-0.11	0.057	NO
79	CDKN2B	CDKN2B	CDKN2B	16533	-0.15	0.027	NO
80	ID2	ID2	ID2	16742	-0.16	0.026	NO
81	MYC	MYC	MYC	16802	-0.17	0.034	NO
82	GDF5	GDF5	GDF5	16979	-0.18	0.036	NO
83	IFNG	IFNG	IFNG	17184	-0.2	0.039	NO
84	TNF	TNF	TNF	17509	-0.25	0.038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TGFB2	TGFB2	TGFB2	61	0.67	0.13	YES
2	CHRD	CHRD	CHRD	218	0.54	0.22	YES
3	BMP7	BMP7	BMP7	262	0.52	0.32	YES
4	SMAD6	SMAD6	SMAD6	594	0.42	0.39	YES
5	NKX2-5	NKX2-5	NKX2-5	800	0.38	0.45	YES
6	BMP5	BMP5	BMP5	934	0.36	0.52	YES
7	GATA4	GATA4	GATA4	1388	0.3	0.55	YES
8	TGFB3	TGFB3	TGFB3	1428	0.29	0.6	YES
9	FZD1	FZD1	FZD1	3249	0.16	0.53	NO
10	BMPR2	BMPR2	BMPR2	3455	0.16	0.55	NO
11	NPPB	NPPB	NPPB	4004	0.13	0.55	NO
12	BMPR1A	BMPR1A	BMPR1A	4624	0.11	0.54	NO
13	MAP3K7	MAP3K7	MAP3K7	4925	0.097	0.54	NO
14	NOG	NOG	NOG	5106	0.092	0.55	NO
15	TGFBR3	TGFBR3	TGFBR3	5298	0.086	0.55	NO
16	NPPA	NPPA	NPPA	5647	0.078	0.55	NO
17	SMAD4	SMAD4	SMAD4	6038	0.069	0.54	NO
18	CTNNB1	CTNNB1	CTNNB1	6392	0.061	0.53	NO
19	TGFB1	TGFB1	TGFB1	6457	0.06	0.54	NO
20	SMAD5	SMAD5	SMAD5	6651	0.056	0.54	NO
21	HNF1A	HNF1A	HNF1A	6964	0.05	0.53	NO
22	WNT1	WNT1	WNT1	7372	0.043	0.52	NO
23	BMP4	BMP4	BMP4	7608	0.039	0.51	NO
24	ACVR1	ACVR1	ACVR1	8483	0.025	0.47	NO
25	DVL1	DVL1	DVL1	8890	0.02	0.45	NO
26	MYL2	MYL2	MYL2	9014	0.018	0.45	NO
27	TGFBR1	TGFBR1	TGFBR1	9984	0.0045	0.4	NO
28	GSK3B	GSK3B	GSK3B	10261	0.00077	0.38	NO
29	SMAD1	SMAD1	SMAD1	10672	-0.0048	0.36	NO
30	RFC1	RFC1	RFC1	11897	-0.022	0.3	NO
31	AXIN1	AXIN1	AXIN1	12068	-0.025	0.29	NO
32	APC	APC	APC	12801	-0.037	0.26	NO
33	TGFBR2	TGFBR2	TGFBR2	12989	-0.04	0.26	NO
34	ATF2	ATF2	ATF2	13601	-0.051	0.23	NO
35	BMP2	BMP2	BMP2	15717	-0.11	0.14	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PTCH2	PTCH2	PTCH2	59	0.68	0.059	YES
2	GLI1	GLI1	GLI1	99	0.62	0.11	YES
3	WNT11	WNT11	WNT11	182	0.56	0.16	YES
4	PTCH1	PTCH1	PTCH1	220	0.54	0.21	YES
5	HHIP	HHIP	HHIP	434	0.47	0.24	YES
6	WNT6	WNT6	WNT6	442	0.47	0.28	YES
7	WNT5B	WNT5B	WNT5B	568	0.43	0.32	YES
8	WNT10B	WNT10B	WNT10B	826	0.38	0.34	YES
9	APC2	APC2	APC2	839	0.38	0.37	YES
10	FZD10	FZD10	FZD10	956	0.36	0.4	YES
11	LEF1	LEF1	LEF1	1080	0.34	0.42	YES
12	FZD8	FZD8	FZD8	1113	0.34	0.45	YES
13	FZD3	FZD3	FZD3	1163	0.33	0.48	YES
14	SMO	SMO	SMO	1285	0.31	0.5	YES
15	FZD2	FZD2	FZD2	1403	0.3	0.52	YES
16	TCF7L1	TCF7L1	TCF7L1	1669	0.27	0.53	YES
17	GLI2	GLI2	GLI2	1960	0.24	0.54	YES
18	TCF7	TCF7	TCF7	2225	0.22	0.54	YES
19	FZD7	FZD7	FZD7	2323	0.22	0.56	YES
20	WNT9A	WNT9A	WNT9A	2517	0.2	0.56	YES
21	WNT7B	WNT7B	WNT7B	2808	0.19	0.57	YES
22	WNT8B	WNT8B	WNT8B	2867	0.18	0.58	YES
23	FZD9	FZD9	FZD9	2999	0.18	0.59	YES
24	WNT7A	WNT7A	WNT7A	3062	0.17	0.6	YES
25	SHH	SHH	SHH	3229	0.16	0.61	YES
26	FZD1	FZD1	FZD1	3249	0.16	0.62	YES
27	FZD4	FZD4	FZD4	3390	0.16	0.63	YES
28	AXIN2	AXIN2	AXIN2	4205	0.12	0.59	NO
29	GLI3	GLI3	GLI3	4216	0.12	0.6	NO
30	TP53	TP53	TP53	4646	0.1	0.59	NO
31	DVL2	DVL2	DVL2	4862	0.098	0.59	NO
32	STK36	STK36	STK36	5190	0.089	0.58	NO
33	WNT2B	WNT2B	WNT2B	5759	0.075	0.55	NO
34	CTNNB1	CTNNB1	CTNNB1	6392	0.061	0.52	NO
35	WNT10A	WNT10A	WNT10A	6453	0.06	0.53	NO
36	WNT1	WNT1	WNT1	7372	0.043	0.48	NO
37	BMP4	BMP4	BMP4	7608	0.039	0.47	NO
38	FZD6	FZD6	FZD6	7981	0.033	0.45	NO
39	WNT16	WNT16	WNT16	8595	0.024	0.42	NO
40	DVL1	DVL1	DVL1	8890	0.02	0.41	NO
41	SUFU	SUFU	SUFU	9006	0.018	0.4	NO
42	GSK3B	GSK3B	GSK3B	10261	0.00077	0.33	NO
43	WNT5A	WNT5A	WNT5A	11060	-0.01	0.29	NO
44	AXIN1	AXIN1	AXIN1	12068	-0.025	0.24	NO
45	APC	APC	APC	12801	-0.037	0.2	NO
46	FZD5	FZD5	FZD5	13376	-0.047	0.17	NO
47	WNT4	WNT4	WNT4	13847	-0.056	0.15	NO
48	TCF7L2	TCF7L2	TCF7L2	14187	-0.063	0.14	NO
49	DVL3	DVL3	DVL3	14782	-0.077	0.11	NO
50	BMP2	BMP2	BMP2	15717	-0.11	0.071	NO
51	WNT9B	WNT9B	WNT9B	16726	-0.16	0.03	NO
52	WNT3	WNT3	WNT3	16971	-0.18	0.034	NO
53	WNT2	WNT2	WNT2	17956	-0.36	0.013	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SFRP5	SFRP5	SFRP5	107	0.61	0.026	YES
2	CAMK2B	CAMK2B	CAMK2B	117	0.6	0.056	YES
3	NKD1	NKD1	NKD1	175	0.57	0.082	YES
4	WNT11	WNT11	WNT11	182	0.56	0.11	YES
5	NKD2	NKD2	NKD2	321	0.5	0.13	YES
6	NFATC4	NFATC4	NFATC4	343	0.49	0.15	YES
7	WNT6	WNT6	WNT6	442	0.47	0.17	YES
8	CXXC4	CXXC4	CXXC4	559	0.44	0.19	YES
9	WNT5B	WNT5B	WNT5B	568	0.43	0.21	YES
10	WNT10B	WNT10B	WNT10B	826	0.38	0.21	YES
11	APC2	APC2	APC2	839	0.38	0.23	YES
12	SFRP1	SFRP1	SFRP1	944	0.36	0.25	YES
13	FZD10	FZD10	FZD10	956	0.36	0.26	YES
14	PRICKLE1	PRICKLE1	PRICKLE1	1001	0.35	0.28	YES
15	LEF1	LEF1	LEF1	1080	0.34	0.29	YES
16	FZD8	FZD8	FZD8	1113	0.34	0.31	YES
17	FZD3	FZD3	FZD3	1163	0.33	0.32	YES
18	MAPK10	MAPK10	MAPK10	1189	0.32	0.34	YES
19	WIF1	WIF1	WIF1	1258	0.31	0.35	YES
20	DAAM2	DAAM2	DAAM2	1375	0.3	0.36	YES
21	FZD2	FZD2	FZD2	1403	0.3	0.37	YES
22	PRKCG	PRKCG	PRKCG	1565	0.28	0.38	YES
23	TCF7L1	TCF7L1	TCF7L1	1669	0.27	0.39	YES
24	LRP6	LRP6	LRP6	1674	0.27	0.4	YES
25	SFRP2	SFRP2	SFRP2	1933	0.25	0.4	YES
26	RAC3	RAC3	RAC3	2042	0.24	0.4	YES
27	VANGL2	VANGL2	VANGL2	2052	0.24	0.42	YES
28	TBL1Y	TBL1Y	TBL1Y	2207	0.23	0.42	YES
29	TCF7	TCF7	TCF7	2225	0.22	0.43	YES
30	FZD7	FZD7	FZD7	2323	0.22	0.44	YES
31	DKK2	DKK2	DKK2	2384	0.21	0.44	YES
32	SOX17	SOX17	SOX17	2492	0.21	0.45	YES
33	WNT9A	WNT9A	WNT9A	2517	0.2	0.46	YES
34	PLCB4	PLCB4	PLCB4	2581	0.2	0.46	YES
35	CAMK2A	CAMK2A	CAMK2A	2773	0.19	0.46	YES
36	WNT7B	WNT7B	WNT7B	2808	0.19	0.47	YES
37	WNT8B	WNT8B	WNT8B	2867	0.18	0.48	YES
38	FZD9	FZD9	FZD9	2999	0.18	0.48	YES
39	WNT7A	WNT7A	WNT7A	3062	0.17	0.48	YES
40	FZD1	FZD1	FZD1	3249	0.16	0.48	YES
41	FZD4	FZD4	FZD4	3390	0.16	0.48	YES
42	CTNNBIP1	CTNNBIP1	CTNNBIP1	3456	0.16	0.49	YES
43	WNT3A	WNT3A	WNT3A	3698	0.14	0.48	NO
44	TBL1X	TBL1X	TBL1X	3863	0.14	0.48	NO
45	NFATC1	NFATC1	NFATC1	3950	0.13	0.48	NO
46	AXIN2	AXIN2	AXIN2	4205	0.12	0.47	NO
47	SMAD3	SMAD3	SMAD3	4307	0.12	0.47	NO
48	CAMK2G	CAMK2G	CAMK2G	4325	0.12	0.48	NO
49	CCND1	CCND1	CCND1	4475	0.11	0.48	NO
50	TP53	TP53	TP53	4646	0.1	0.47	NO
51	CSNK1E	CSNK1E	CSNK1E	4763	0.1	0.47	NO
52	DVL2	DVL2	DVL2	4862	0.098	0.47	NO
53	MAP3K7	MAP3K7	MAP3K7	4925	0.097	0.47	NO
54	CREBBP	CREBBP	CREBBP	4938	0.096	0.48	NO
55	PPP3CA	PPP3CA	PPP3CA	5165	0.09	0.47	NO
56	FRAT1	FRAT1	FRAT1	5340	0.086	0.46	NO
57	MMP7	MMP7	MMP7	5514	0.081	0.46	NO
58	WNT2B	WNT2B	WNT2B	5759	0.075	0.45	NO
59	PRKACA	PRKACA	PRKACA	5993	0.07	0.44	NO
60	SMAD4	SMAD4	SMAD4	6038	0.069	0.44	NO
61	SFRP4	SFRP4	SFRP4	6080	0.068	0.44	NO
62	PRKX	PRKX	PRKX	6173	0.066	0.44	NO
63	CTNNB1	CTNNB1	CTNNB1	6392	0.061	0.43	NO
64	WNT10A	WNT10A	WNT10A	6453	0.06	0.43	NO
65	ROCK1	ROCK1	ROCK1	6659	0.056	0.42	NO
66	PPP2R1A	PPP2R1A	PPP2R1A	6744	0.054	0.42	NO
67	PPARD	PPARD	PPARD	6827	0.053	0.42	NO
68	PPP2R5D	PPP2R5D	PPP2R5D	6935	0.051	0.41	NO
69	CHD8	CHD8	CHD8	7027	0.049	0.41	NO
70	SIAH1	SIAH1	SIAH1	7232	0.045	0.4	NO
71	SMAD2	SMAD2	SMAD2	7317	0.044	0.4	NO
72	CAMK2D	CAMK2D	CAMK2D	7324	0.044	0.4	NO
73	WNT1	WNT1	WNT1	7372	0.043	0.4	NO
74	PPP3CB	PPP3CB	PPP3CB	7754	0.037	0.38	NO
75	EP300	EP300	EP300	7923	0.034	0.38	NO
76	FZD6	FZD6	FZD6	7981	0.033	0.37	NO
77	NFATC2	NFATC2	NFATC2	8128	0.03	0.37	NO
78	PPP3R1	PPP3R1	PPP3R1	8236	0.029	0.36	NO
79	CTBP1	CTBP1	CTBP1	8433	0.026	0.35	NO
80	PPP2CB	PPP2CB	PPP2CB	8467	0.026	0.35	NO
81	WNT16	WNT16	WNT16	8595	0.024	0.35	NO
82	CSNK2A1	CSNK2A1	CSNK2A1	8603	0.024	0.35	NO
83	NFATC3	NFATC3	NFATC3	8689	0.023	0.34	NO
84	NFAT5	NFAT5	NFAT5	8711	0.022	0.34	NO
85	DVL1	DVL1	DVL1	8890	0.02	0.34	NO
86	PPP2R5C	PPP2R5C	PPP2R5C	8928	0.019	0.33	NO
87	PRKACB	PRKACB	PRKACB	9119	0.016	0.32	NO
88	CSNK2A2	CSNK2A2	CSNK2A2	9310	0.014	0.31	NO
89	CUL1	CUL1	CUL1	9575	0.01	0.3	NO
90	NLK	NLK	NLK	9608	0.0097	0.3	NO
91	LRP5	LRP5	LRP5	9780	0.0075	0.29	NO
92	CACYBP	CACYBP	CACYBP	9790	0.0074	0.29	NO
93	GSK3B	GSK3B	GSK3B	10261	0.00077	0.26	NO
94	RAC1	RAC1	RAC1	10283	0.00049	0.26	NO
95	MAPK8	MAPK8	MAPK8	10294	0.00034	0.26	NO
96	PPP2R5E	PPP2R5E	PPP2R5E	10296	0.00029	0.26	NO
97	VANGL1	VANGL1	VANGL1	10416	-0.0013	0.26	NO
98	JUN	JUN	JUN	10806	-0.0068	0.23	NO
99	CTBP2	CTBP2	CTBP2	10854	-0.0074	0.23	NO
100	RUVBL1	RUVBL1	RUVBL1	10910	-0.0083	0.23	NO
101	PRICKLE2	PRICKLE2	PRICKLE2	11042	-0.01	0.22	NO
102	WNT5A	WNT5A	WNT5A	11060	-0.01	0.22	NO
103	FBXW11	FBXW11	FBXW11	11125	-0.011	0.22	NO
104	CSNK2B	CSNK2B	CSNK2B	11272	-0.013	0.21	NO
105	CSNK1A1	CSNK1A1	CSNK1A1	11306	-0.014	0.21	NO
106	FOSL1	FOSL1	FOSL1	11310	-0.014	0.21	NO
107	PSEN1	PSEN1	PSEN1	11745	-0.02	0.19	NO
108	TBL1XR1	TBL1XR1	TBL1XR1	11777	-0.021	0.19	NO
109	PPP2R5A	PPP2R5A	PPP2R5A	11851	-0.022	0.18	NO
110	SKP1	SKP1	SKP1	12006	-0.024	0.18	NO
111	RBX1	RBX1	RBX1	12016	-0.024	0.18	NO
112	BTRC	BTRC	BTRC	12040	-0.025	0.18	NO
113	AXIN1	AXIN1	AXIN1	12068	-0.025	0.18	NO
114	ROCK2	ROCK2	ROCK2	12211	-0.027	0.17	NO
115	CHP2	CHP2	CHP2	12459	-0.031	0.16	NO
116	PLCB3	PLCB3	PLCB3	12765	-0.036	0.14	NO
117	APC	APC	APC	12801	-0.037	0.14	NO
118	PPP2R1B	PPP2R1B	PPP2R1B	12936	-0.039	0.14	NO
119	RHOA	RHOA	RHOA	13234	-0.044	0.12	NO
120	PORCN	PORCN	PORCN	13235	-0.044	0.13	NO
121	DKK1	DKK1	DKK1	13269	-0.045	0.13	NO
122	PPP2CA	PPP2CA	PPP2CA	13349	-0.046	0.13	NO
123	FZD5	FZD5	FZD5	13376	-0.047	0.13	NO
124	CCND3	CCND3	CCND3	13540	-0.05	0.12	NO
125	PPP3CC	PPP3CC	PPP3CC	13594	-0.051	0.12	NO
126	MAPK9	MAPK9	MAPK9	13598	-0.051	0.12	NO
127	WNT4	WNT4	WNT4	13847	-0.056	0.11	NO
128	TCF7L2	TCF7L2	TCF7L2	14187	-0.063	0.096	NO
129	FRAT2	FRAT2	FRAT2	14622	-0.073	0.076	NO
130	PRKCA	PRKCA	PRKCA	14691	-0.075	0.076	NO
131	DVL3	DVL3	DVL3	14782	-0.077	0.074	NO
132	SENP2	SENP2	SENP2	14833	-0.078	0.076	NO
133	PLCB1	PLCB1	PLCB1	15180	-0.088	0.061	NO
134	PLCB2	PLCB2	PLCB2	15250	-0.089	0.062	NO
135	CCND2	CCND2	CCND2	15615	-0.1	0.047	NO
136	RAC2	RAC2	RAC2	16173	-0.13	0.023	NO
137	CSNK1A1L	CSNK1A1L	CSNK1A1L	16253	-0.13	0.025	NO
138	WNT9B	WNT9B	WNT9B	16726	-0.16	0.0071	NO
139	MYC	MYC	MYC	16802	-0.17	0.012	NO
140	WNT3	WNT3	WNT3	16971	-0.18	0.012	NO
141	CHP	CHP	CHP	17054	-0.19	0.017	NO
142	DAAM1	DAAM1	DAAM1	17525	-0.25	0.0033	NO
143	PRKCB	PRKCB	PRKCB	17708	-0.28	0.0078	NO
144	WNT2	WNT2	WNT2	17956	-0.36	0.013	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CAMK2B	CAMK2B	CAMK2B	117	0.6	0.034	YES
2	ADCY5	ADCY5	ADCY5	167	0.57	0.069	YES
3	WNT11	WNT11	WNT11	182	0.56	0.1	YES
4	GNAO1	GNAO1	GNAO1	385	0.48	0.13	YES
5	WNT6	WNT6	WNT6	442	0.47	0.15	YES
6	CALML3	CALML3	CALML3	455	0.46	0.18	YES
7	ADCY2	ADCY2	ADCY2	502	0.45	0.21	YES
8	WNT5B	WNT5B	WNT5B	568	0.43	0.24	YES
9	ADCY1	ADCY1	ADCY1	818	0.38	0.25	YES
10	WNT10B	WNT10B	WNT10B	826	0.38	0.27	YES
11	CALML5	CALML5	CALML5	948	0.36	0.29	YES
12	FZD10	FZD10	FZD10	956	0.36	0.31	YES
13	LEF1	LEF1	LEF1	1080	0.34	0.33	YES
14	FZD8	FZD8	FZD8	1113	0.34	0.35	YES
15	FZD3	FZD3	FZD3	1163	0.33	0.37	YES
16	FZD2	FZD2	FZD2	1403	0.3	0.38	YES
17	PRKCG	PRKCG	PRKCG	1565	0.28	0.38	YES
18	TCF7L1	TCF7L1	TCF7L1	1669	0.27	0.4	YES
19	TCF7	TCF7	TCF7	2225	0.22	0.38	YES
20	FZD7	FZD7	FZD7	2323	0.22	0.39	YES
21	CREB3L1	CREB3L1	CREB3L1	2359	0.22	0.4	YES
22	WNT9A	WNT9A	WNT9A	2517	0.2	0.41	YES
23	EDNRB	EDNRB	EDNRB	2566	0.2	0.42	YES
24	PLCB4	PLCB4	PLCB4	2581	0.2	0.43	YES
25	CREB3L3	CREB3L3	CREB3L3	2711	0.19	0.44	YES
26	TYR	TYR	TYR	2732	0.19	0.45	YES
27	CAMK2A	CAMK2A	CAMK2A	2773	0.19	0.46	YES
28	WNT7B	WNT7B	WNT7B	2808	0.19	0.47	YES
29	WNT8B	WNT8B	WNT8B	2867	0.18	0.48	YES
30	ADCY8	ADCY8	ADCY8	2880	0.18	0.49	YES
31	FZD9	FZD9	FZD9	2999	0.18	0.5	YES
32	WNT7A	WNT7A	WNT7A	3062	0.17	0.5	YES
33	FZD1	FZD1	FZD1	3249	0.16	0.5	YES
34	KIT	KIT	KIT	3308	0.16	0.51	YES
35	TYRP1	TYRP1	TYRP1	3336	0.16	0.52	YES
36	FZD4	FZD4	FZD4	3390	0.16	0.53	YES
37	EDN1	EDN1	EDN1	3624	0.15	0.52	YES
38	WNT3A	WNT3A	WNT3A	3698	0.14	0.53	YES
39	CAMK2G	CAMK2G	CAMK2G	4325	0.12	0.5	NO
40	ADCY4	ADCY4	ADCY4	4353	0.12	0.51	NO
41	ADCY6	ADCY6	ADCY6	4620	0.11	0.5	NO
42	MC1R	MC1R	MC1R	4654	0.1	0.51	NO
43	DVL2	DVL2	DVL2	4862	0.098	0.5	NO
44	CREBBP	CREBBP	CREBBP	4938	0.096	0.5	NO
45	CALM1	CALM1	CALM1	5734	0.076	0.46	NO
46	WNT2B	WNT2B	WNT2B	5759	0.075	0.47	NO
47	ASIP	ASIP	ASIP	5816	0.074	0.47	NO
48	KITLG	KITLG	KITLG	5955	0.071	0.47	NO
49	PRKACA	PRKACA	PRKACA	5993	0.07	0.47	NO
50	PRKX	PRKX	PRKX	6173	0.066	0.46	NO
51	CTNNB1	CTNNB1	CTNNB1	6392	0.061	0.46	NO
52	WNT10A	WNT10A	WNT10A	6453	0.06	0.46	NO
53	KRAS	KRAS	KRAS	6619	0.056	0.45	NO
54	CAMK2D	CAMK2D	CAMK2D	7324	0.044	0.42	NO
55	WNT1	WNT1	WNT1	7372	0.043	0.42	NO
56	CREB1	CREB1	CREB1	7612	0.039	0.41	NO
57	GNAS	GNAS	GNAS	7824	0.036	0.4	NO
58	MAP2K2	MAP2K2	MAP2K2	7827	0.035	0.4	NO
59	CALM3	CALM3	CALM3	7916	0.034	0.4	NO
60	EP300	EP300	EP300	7923	0.034	0.4	NO
61	FZD6	FZD6	FZD6	7981	0.033	0.4	NO
62	CREB3L4	CREB3L4	CREB3L4	8506	0.025	0.37	NO
63	WNT16	WNT16	WNT16	8595	0.024	0.37	NO
64	DVL1	DVL1	DVL1	8890	0.02	0.35	NO
65	PRKACB	PRKACB	PRKACB	9119	0.016	0.34	NO
66	CREB3L2	CREB3L2	CREB3L2	9269	0.014	0.33	NO
67	GNAQ	GNAQ	GNAQ	9307	0.014	0.33	NO
68	MAPK1	MAPK1	MAPK1	10177	0.0018	0.28	NO
69	GSK3B	GSK3B	GSK3B	10261	0.00077	0.28	NO
70	RAF1	RAF1	RAF1	10279	0.00052	0.28	NO
71	CALML6	CALML6	CALML6	10900	-0.0081	0.24	NO
72	WNT5A	WNT5A	WNT5A	11060	-0.01	0.24	NO
73	ADCY7	ADCY7	ADCY7	11493	-0.017	0.21	NO
74	POMC	POMC	POMC	11695	-0.02	0.2	NO
75	CALM2	CALM2	CALM2	11968	-0.024	0.19	NO
76	NRAS	NRAS	NRAS	11996	-0.024	0.19	NO
77	HRAS	HRAS	HRAS	12025	-0.024	0.19	NO
78	GNAI2	GNAI2	GNAI2	12159	-0.027	0.18	NO
79	PLCB3	PLCB3	PLCB3	12765	-0.036	0.15	NO
80	ADCY9	ADCY9	ADCY9	13365	-0.047	0.12	NO
81	FZD5	FZD5	FZD5	13376	-0.047	0.13	NO
82	GNAI3	GNAI3	GNAI3	13466	-0.048	0.12	NO
83	MAPK3	MAPK3	MAPK3	13791	-0.055	0.11	NO
84	WNT4	WNT4	WNT4	13847	-0.056	0.11	NO
85	TCF7L2	TCF7L2	TCF7L2	14187	-0.063	0.097	NO
86	MAP2K1	MAP2K1	MAP2K1	14261	-0.065	0.097	NO
87	PRKCA	PRKCA	PRKCA	14691	-0.075	0.078	NO
88	DVL3	DVL3	DVL3	14782	-0.077	0.078	NO
89	CREB3	CREB3	CREB3	14924	-0.081	0.076	NO
90	PLCB1	PLCB1	PLCB1	15180	-0.088	0.068	NO
91	PLCB2	PLCB2	PLCB2	15250	-0.089	0.07	NO
92	DCT	DCT	DCT	15474	-0.097	0.064	NO
93	MITF	MITF	MITF	16437	-0.14	0.02	NO
94	WNT9B	WNT9B	WNT9B	16726	-0.16	0.015	NO
95	GNAI1	GNAI1	GNAI1	16762	-0.16	0.024	NO
96	WNT3	WNT3	WNT3	16971	-0.18	0.024	NO
97	PRKCB	PRKCB	PRKCB	17708	-0.28	0.0022	NO
98	WNT2	WNT2	WNT2	17956	-0.36	0.013	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADCY5	ADCY5	ADCY5	167	0.57	0.041	YES
2	DRD1	DRD1	DRD1	170	0.57	0.091	YES
3	ADCY2	ADCY2	ADCY2	502	0.45	0.11	YES
4	TUBB8	TUBB8	TUBB8	557	0.44	0.15	YES
5	DRD2	DRD2	DRD2	634	0.42	0.18	YES
6	GUCY1B3	GUCY1B3	GUCY1B3	694	0.4	0.21	YES
7	PRKG1	PRKG1	PRKG1	748	0.39	0.24	YES
8	ADCY1	ADCY1	ADCY1	818	0.38	0.28	YES
9	GUCY1A2	GUCY1A2	GUCY1A2	945	0.36	0.3	YES
10	GUCY1A3	GUCY1A3	GUCY1A3	1087	0.34	0.32	YES
11	TUBA8	TUBA8	TUBA8	1182	0.32	0.35	YES
12	GRM1	GRM1	GRM1	1519	0.28	0.35	YES
13	PDGFRB	PDGFRB	PDGFRB	1553	0.28	0.38	YES
14	PRKCG	PRKCG	PRKCG	1565	0.28	0.4	YES
15	TUBB4Q	TUBB4Q	TUBB4Q	1595	0.28	0.42	YES
16	TUBB1	TUBB1	TUBB1	1751	0.26	0.44	YES
17	TUBA3D	TUBA3D	TUBA3D	2136	0.23	0.44	YES
18	PDGFC	PDGFC	PDGFC	2282	0.22	0.45	YES
19	GRM5	GRM5	GRM5	2393	0.21	0.46	YES
20	PLCB4	PLCB4	PLCB4	2581	0.2	0.47	YES
21	PDGFA	PDGFA	PDGFA	2658	0.2	0.48	YES
22	ADCY8	ADCY8	ADCY8	2880	0.18	0.48	YES
23	TUBA1A	TUBA1A	TUBA1A	2901	0.18	0.5	YES
24	TUBB2B	TUBB2B	TUBB2B	3296	0.16	0.49	YES
25	CDK1	CDK1	CDK1	3341	0.16	0.5	YES
26	HTR2B	HTR2B	HTR2B	3407	0.16	0.51	YES
27	TUBA3E	TUBA3E	TUBA3E	3448	0.16	0.53	YES
28	SRC	SRC	SRC	4228	0.12	0.49	NO
29	ADCY4	ADCY4	ADCY4	4353	0.12	0.5	NO
30	ADCY6	ADCY6	ADCY6	4620	0.11	0.49	NO
31	TUBB4	TUBB4	TUBB4	4845	0.099	0.49	NO
32	TUBAL3	TUBAL3	TUBAL3	5005	0.094	0.49	NO
33	MAPK7	MAPK7	MAPK7	5144	0.09	0.49	NO
34	TUBB3	TUBB3	TUBB3	5324	0.086	0.49	NO
35	PRKACA	PRKACA	PRKACA	5993	0.07	0.46	NO
36	PRKX	PRKX	PRKX	6173	0.066	0.45	NO
37	EGF	EGF	EGF	6437	0.06	0.44	NO
38	KRAS	KRAS	KRAS	6619	0.056	0.44	NO
39	PRKG2	PRKG2	PRKG2	6780	0.053	0.43	NO
40	PDGFRA	PDGFRA	PDGFRA	7256	0.045	0.41	NO
41	PDGFD	PDGFD	PDGFD	7802	0.036	0.38	NO
42	GNAS	GNAS	GNAS	7824	0.036	0.39	NO
43	MAP2K2	MAP2K2	MAP2K2	7827	0.035	0.39	NO
44	TUBA1B	TUBA1B	TUBA1B	7874	0.035	0.39	NO
45	GNA11	GNA11	GNA11	7888	0.034	0.39	NO
46	TUBB	TUBB	TUBB	8021	0.032	0.39	NO
47	ADRB1	ADRB1	ADRB1	8504	0.025	0.36	NO
48	TJP1	TJP1	TJP1	8602	0.024	0.36	NO
49	HTR2A	HTR2A	HTR2A	8662	0.023	0.36	NO
50	PRKACB	PRKACB	PRKACB	9119	0.016	0.33	NO
51	GNAQ	GNAQ	GNAQ	9307	0.014	0.32	NO
52	ITPR2	ITPR2	ITPR2	9402	0.012	0.32	NO
53	PDGFB	PDGFB	PDGFB	9762	0.0078	0.3	NO
54	ITPR3	ITPR3	ITPR3	9776	0.0076	0.3	NO
55	TUBB2C	TUBB2C	TUBB2C	9989	0.0045	0.29	NO
56	GJA1	GJA1	GJA1	10030	0.0038	0.29	NO
57	MAPK1	MAPK1	MAPK1	10177	0.0018	0.28	NO
58	LPAR1	LPAR1	LPAR1	10206	0.0015	0.28	NO
59	RAF1	RAF1	RAF1	10279	0.00052	0.28	NO
60	SOS1	SOS1	SOS1	10615	-0.004	0.26	NO
61	CSNK1D	CSNK1D	CSNK1D	11434	-0.016	0.21	NO
62	ADCY7	ADCY7	ADCY7	11493	-0.017	0.21	NO
63	SOS2	SOS2	SOS2	11543	-0.017	0.21	NO
64	MAP2K5	MAP2K5	MAP2K5	11820	-0.021	0.2	NO
65	NRAS	NRAS	NRAS	11996	-0.024	0.19	NO
66	TUBB6	TUBB6	TUBB6	12010	-0.024	0.19	NO
67	HRAS	HRAS	HRAS	12025	-0.024	0.19	NO
68	GNAI2	GNAI2	GNAI2	12159	-0.027	0.19	NO
69	PLCB3	PLCB3	PLCB3	12765	-0.036	0.16	NO
70	GRB2	GRB2	GRB2	12984	-0.04	0.15	NO
71	ADCY9	ADCY9	ADCY9	13365	-0.047	0.13	NO
72	GNAI3	GNAI3	GNAI3	13466	-0.048	0.13	NO
73	ITPR1	ITPR1	ITPR1	13553	-0.05	0.13	NO
74	MAPK3	MAPK3	MAPK3	13791	-0.055	0.12	NO
75	TUBB2A	TUBB2A	TUBB2A	13963	-0.058	0.12	NO
76	MAP2K1	MAP2K1	MAP2K1	14261	-0.065	0.11	NO
77	TUBA1C	TUBA1C	TUBA1C	14575	-0.072	0.096	NO
78	MAP3K2	MAP3K2	MAP3K2	14600	-0.072	0.1	NO
79	PRKCA	PRKCA	PRKCA	14691	-0.075	0.1	NO
80	TUBA4A	TUBA4A	TUBA4A	15065	-0.084	0.09	NO
81	PLCB1	PLCB1	PLCB1	15180	-0.088	0.091	NO
82	PLCB2	PLCB2	PLCB2	15250	-0.089	0.095	NO
83	TUBA3C	TUBA3C	TUBA3C	15879	-0.11	0.071	NO
84	GNAI1	GNAI1	GNAI1	16762	-0.16	0.036	NO
85	EGFR	EGFR	EGFR	17086	-0.19	0.036	NO
86	PRKCB	PRKCB	PRKCB	17708	-0.28	0.026	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NKD1	NKD1	NKD1	175	0.57	0.04	YES
2	WNT11	WNT11	WNT11	182	0.56	0.09	YES
3	WNT6	WNT6	WNT6	442	0.47	0.12	YES
4	CXXC4	CXXC4	CXXC4	559	0.44	0.15	YES
5	WNT5B	WNT5B	WNT5B	568	0.43	0.19	YES
6	FRZB	FRZB	FRZB	771	0.39	0.21	YES
7	SFRP1	SFRP1	SFRP1	944	0.36	0.23	YES
8	LEF1	LEF1	LEF1	1080	0.34	0.26	YES
9	FZD8	FZD8	FZD8	1113	0.34	0.28	YES
10	FZD3	FZD3	FZD3	1163	0.33	0.31	YES
11	WIF1	WIF1	WIF1	1258	0.31	0.33	YES
12	FZD2	FZD2	FZD2	1403	0.3	0.35	YES
13	PYGO1	PYGO1	PYGO1	1621	0.27	0.36	YES
14	TCF7L1	TCF7L1	TCF7L1	1669	0.27	0.38	YES
15	LRP6	LRP6	LRP6	1674	0.27	0.41	YES
16	TCF7	TCF7	TCF7	2225	0.22	0.4	YES
17	PITX2	PITX2	PITX2	2236	0.22	0.42	YES
18	TLE2	TLE2	TLE2	2321	0.22	0.43	YES
19	FZD7	FZD7	FZD7	2323	0.22	0.45	YES
20	SOX17	SOX17	SOX17	2492	0.21	0.46	YES
21	WNT9A	WNT9A	WNT9A	2517	0.2	0.48	YES
22	WNT7B	WNT7B	WNT7B	2808	0.19	0.48	YES
23	WNT7A	WNT7A	WNT7A	3062	0.17	0.48	YES
24	FZD1	FZD1	FZD1	3249	0.16	0.48	YES
25	FZD4	FZD4	FZD4	3390	0.16	0.49	YES
26	CTNNBIP1	CTNNBIP1	CTNNBIP1	3456	0.16	0.5	YES
27	DIXDC1	DIXDC1	DIXDC1	3577	0.15	0.5	YES
28	BCL9	BCL9	BCL9	3928	0.13	0.5	NO
29	FOXN1	FOXN1	FOXN1	4459	0.11	0.48	NO
30	CCND1	CCND1	CCND1	4475	0.11	0.49	NO
31	TLE1	TLE1	TLE1	4747	0.1	0.48	NO
32	DVL2	DVL2	DVL2	4862	0.098	0.48	NO
33	FRAT1	FRAT1	FRAT1	5340	0.086	0.46	NO
34	WNT2B	WNT2B	WNT2B	5759	0.075	0.45	NO
35	SFRP4	SFRP4	SFRP4	6080	0.068	0.44	NO
36	CTNNB1	CTNNB1	CTNNB1	6392	0.061	0.42	NO
37	WNT10A	WNT10A	WNT10A	6453	0.06	0.43	NO
38	PPP2R1A	PPP2R1A	PPP2R1A	6744	0.054	0.42	NO
39	AES	AES	AES	7127	0.047	0.4	NO
40	GSK3A	GSK3A	GSK3A	7218	0.046	0.4	NO
41	FBXW2	FBXW2	FBXW2	7257	0.045	0.4	NO
42	WNT1	WNT1	WNT1	7372	0.043	0.4	NO
43	FBXW4	FBXW4	FBXW4	7541	0.04	0.39	NO
44	EP300	EP300	EP300	7923	0.034	0.37	NO
45	FZD6	FZD6	FZD6	7981	0.033	0.37	NO
46	RPL13A	RPL13A	RPL13A	7984	0.033	0.38	NO
47	CTBP1	CTBP1	CTBP1	8433	0.026	0.35	NO
48	WNT16	WNT16	WNT16	8595	0.024	0.35	NO
49	CSNK2A1	CSNK2A1	CSNK2A1	8603	0.024	0.35	NO
50	DVL1	DVL1	DVL1	8890	0.02	0.33	NO
51	NLK	NLK	NLK	9608	0.0097	0.3	NO
52	LRP5	LRP5	LRP5	9780	0.0075	0.29	NO
53	GSK3B	GSK3B	GSK3B	10261	0.00077	0.26	NO
54	JUN	JUN	JUN	10806	-0.0068	0.23	NO
55	CTBP2	CTBP2	CTBP2	10854	-0.0074	0.23	NO
56	WISP1	WISP1	WISP1	10927	-0.0085	0.23	NO
57	WNT5A	WNT5A	WNT5A	11060	-0.01	0.22	NO
58	FBXW11	FBXW11	FBXW11	11125	-0.011	0.22	NO
59	HPRT1	HPRT1	HPRT1	11189	-0.012	0.21	NO
60	CSNK1A1	CSNK1A1	CSNK1A1	11306	-0.014	0.21	NO
61	FOSL1	FOSL1	FOSL1	11310	-0.014	0.21	NO
62	CSNK1D	CSNK1D	CSNK1D	11434	-0.016	0.2	NO
63	GAPDH	GAPDH	GAPDH	11467	-0.016	0.2	NO
64	ACTB	ACTB	ACTB	11675	-0.019	0.2	NO
65	BTRC	BTRC	BTRC	12040	-0.025	0.18	NO
66	AXIN1	AXIN1	AXIN1	12068	-0.025	0.18	NO
67	KREMEN1	KREMEN1	KREMEN1	12224	-0.028	0.17	NO
68	APC	APC	APC	12801	-0.037	0.14	NO
69	CSNK1G1	CSNK1G1	CSNK1G1	13097	-0.042	0.13	NO
70	PORCN	PORCN	PORCN	13235	-0.044	0.13	NO
71	DKK1	DKK1	DKK1	13269	-0.045	0.13	NO
72	PPP2CA	PPP2CA	PPP2CA	13349	-0.046	0.13	NO
73	FZD5	FZD5	FZD5	13376	-0.047	0.13	NO
74	CCND3	CCND3	CCND3	13540	-0.05	0.13	NO
75	RHOU	RHOU	RHOU	13819	-0.055	0.12	NO
76	WNT4	WNT4	WNT4	13847	-0.056	0.12	NO
77	SENP2	SENP2	SENP2	14833	-0.078	0.072	NO
78	SLC9A3R1	SLC9A3R1	SLC9A3R1	15076	-0.084	0.066	NO
79	CCND2	CCND2	CCND2	15615	-0.1	0.045	NO
80	B2M	B2M	B2M	16198	-0.13	0.025	NO
81	MYC	MYC	MYC	16802	-0.17	0.0062	NO
82	WNT3	WNT3	WNT3	16971	-0.18	0.013	NO
83	DAAM1	DAAM1	DAAM1	17525	-0.25	0.0042	NO
84	WNT2	WNT2	WNT2	17956	-0.36	0.013	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HES5	HES5	HES5	180	0.56	0.09	YES
2	NOTCH3	NOTCH3	NOTCH3	658	0.41	0.14	YES
3	DTX1	DTX1	DTX1	803	0.38	0.2	YES
4	DLL1	DLL1	DLL1	1326	0.3	0.22	YES
5	LFNG	LFNG	LFNG	1798	0.26	0.24	YES
6	NOTCH4	NOTCH4	NOTCH4	1965	0.24	0.27	YES
7	JAG1	JAG1	JAG1	2190	0.23	0.3	YES
8	HES1	HES1	HES1	2211	0.23	0.34	YES
9	NOTCH1	NOTCH1	NOTCH1	2473	0.21	0.36	YES
10	NOTCH2	NOTCH2	NOTCH2	2750	0.19	0.38	YES
11	JAG2	JAG2	JAG2	2990	0.18	0.4	YES
12	DTX3	DTX3	DTX3	3000	0.18	0.43	YES
13	MAML3	MAML3	MAML3	3481	0.15	0.43	YES
14	HDAC2	HDAC2	HDAC2	3744	0.14	0.44	YES
15	DLL4	DLL4	DLL4	3990	0.13	0.45	YES
16	DLL3	DLL3	DLL3	4520	0.11	0.44	YES
17	DVL2	DVL2	DVL2	4862	0.098	0.44	YES
18	CREBBP	CREBBP	CREBBP	4938	0.096	0.45	YES
19	NUMBL	NUMBL	NUMBL	5113	0.091	0.46	YES
20	RBPJ	RBPJ	RBPJ	5470	0.082	0.45	YES
21	MAML1	MAML1	MAML1	5722	0.076	0.45	YES
22	NCOR2	NCOR2	NCOR2	5846	0.073	0.46	YES
23	HDAC1	HDAC1	HDAC1	6125	0.067	0.46	YES
24	RBPJL	RBPJL	RBPJL	6184	0.066	0.46	YES
25	KAT2A	KAT2A	KAT2A	7850	0.035	0.38	NO
26	EP300	EP300	EP300	7923	0.034	0.38	NO
27	MAML2	MAML2	MAML2	7967	0.033	0.38	NO
28	CTBP1	CTBP1	CTBP1	8433	0.026	0.36	NO
29	DVL1	DVL1	DVL1	8890	0.02	0.34	NO
30	NUMB	NUMB	NUMB	9189	0.015	0.33	NO
31	SNW1	SNW1	SNW1	9574	0.01	0.31	NO
32	CTBP2	CTBP2	CTBP2	10854	-0.0074	0.24	NO
33	NCSTN	NCSTN	NCSTN	10947	-0.0087	0.23	NO
34	RFNG	RFNG	RFNG	11340	-0.014	0.22	NO
35	PSEN1	PSEN1	PSEN1	11745	-0.02	0.2	NO
36	CIR1	CIR1	CIR1	11769	-0.021	0.2	NO
37	APH1A	APH1A	APH1A	11809	-0.021	0.2	NO
38	ADAM17	ADAM17	ADAM17	12345	-0.029	0.18	NO
39	DTX4	DTX4	DTX4	14395	-0.068	0.075	NO
40	PSEN2	PSEN2	PSEN2	14578	-0.072	0.078	NO
41	PSENEN	PSENEN	PSENEN	14645	-0.073	0.087	NO
42	DVL3	DVL3	DVL3	14782	-0.077	0.093	NO
43	DTX2	DTX2	DTX2	15408	-0.095	0.076	NO
44	DTX3L	DTX3L	DTX3L	16048	-0.12	0.062	NO
45	KAT2B	KAT2B	KAT2B	16515	-0.15	0.062	NO
46	PTCRA	PTCRA	PTCRA	16855	-0.17	0.073	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ZIC2	ZIC2	ZIC2	58	0.68	0.06	YES
2	PTCH2	PTCH2	PTCH2	59	0.68	0.12	YES
3	GLI1	GLI1	GLI1	99	0.62	0.18	YES
4	WNT11	WNT11	WNT11	182	0.56	0.22	YES
5	PTCH1	PTCH1	PTCH1	220	0.54	0.27	YES
6	BMP7	BMP7	BMP7	262	0.52	0.32	YES
7	BMP6	BMP6	BMP6	342	0.49	0.36	YES
8	HHIP	HHIP	HHIP	434	0.47	0.4	YES
9	WNT6	WNT6	WNT6	442	0.47	0.44	YES
10	WNT5B	WNT5B	WNT5B	568	0.43	0.47	YES
11	WNT10B	WNT10B	WNT10B	826	0.38	0.5	YES
12	BMP5	BMP5	BMP5	934	0.36	0.52	YES
13	SMO	SMO	SMO	1285	0.31	0.53	YES
14	BMP8A	BMP8A	BMP8A	1505	0.28	0.55	YES
15	GLI2	GLI2	GLI2	1960	0.24	0.54	YES
16	BMP8B	BMP8B	BMP8B	2342	0.22	0.54	YES
17	RAB23	RAB23	RAB23	2439	0.21	0.56	YES
18	WNT9A	WNT9A	WNT9A	2517	0.2	0.57	YES
19	WNT7B	WNT7B	WNT7B	2808	0.19	0.57	YES
20	WNT8B	WNT8B	WNT8B	2867	0.18	0.59	YES
21	DHH	DHH	DHH	3036	0.17	0.59	YES
22	WNT7A	WNT7A	WNT7A	3062	0.17	0.61	YES
23	SHH	SHH	SHH	3229	0.16	0.61	YES
24	IHH	IHH	IHH	3656	0.15	0.6	NO
25	GLI3	GLI3	GLI3	4216	0.12	0.58	NO
26	CSNK1E	CSNK1E	CSNK1E	4763	0.1	0.56	NO
27	STK36	STK36	STK36	5190	0.089	0.55	NO
28	WNT2B	WNT2B	WNT2B	5759	0.075	0.52	NO
29	PRKACA	PRKACA	PRKACA	5993	0.07	0.52	NO
30	PRKX	PRKX	PRKX	6173	0.066	0.51	NO
31	WNT10A	WNT10A	WNT10A	6453	0.06	0.5	NO
32	CSNK1G2	CSNK1G2	CSNK1G2	6787	0.053	0.49	NO
33	WNT1	WNT1	WNT1	7372	0.043	0.46	NO
34	BMP4	BMP4	BMP4	7608	0.039	0.45	NO
35	WNT16	WNT16	WNT16	8595	0.024	0.4	NO
36	SUFU	SUFU	SUFU	9006	0.018	0.38	NO
37	PRKACB	PRKACB	PRKACB	9119	0.016	0.38	NO
38	CSNK1G3	CSNK1G3	CSNK1G3	9649	0.0092	0.35	NO
39	GSK3B	GSK3B	GSK3B	10261	0.00077	0.31	NO
40	WNT5A	WNT5A	WNT5A	11060	-0.01	0.27	NO
41	FBXW11	FBXW11	FBXW11	11125	-0.011	0.27	NO
42	CSNK1A1	CSNK1A1	CSNK1A1	11306	-0.014	0.26	NO
43	CSNK1D	CSNK1D	CSNK1D	11434	-0.016	0.25	NO
44	LRP2	LRP2	LRP2	11879	-0.022	0.23	NO
45	BTRC	BTRC	BTRC	12040	-0.025	0.22	NO
46	CSNK1G1	CSNK1G1	CSNK1G1	13097	-0.042	0.17	NO
47	WNT4	WNT4	WNT4	13847	-0.056	0.13	NO
48	BMP2	BMP2	BMP2	15717	-0.11	0.04	NO
49	CSNK1A1L	CSNK1A1L	CSNK1A1L	16253	-0.13	0.023	NO
50	WNT9B	WNT9B	WNT9B	16726	-0.16	0.012	NO
51	WNT3	WNT3	WNT3	16971	-0.18	0.015	NO
52	GAS1	GAS1	GAS1	17133	-0.2	0.024	NO
53	WNT2	WNT2	WNT2	17956	-0.36	0.013	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CAMK2B	CAMK2B	CAMK2B	117	0.6	0.076	YES
2	CALML3	CALML3	CALML3	455	0.46	0.12	YES
3	PPP1R1A	PPP1R1A	PPP1R1A	707	0.4	0.16	YES
4	CALML5	CALML5	CALML5	948	0.36	0.2	YES
5	RPS6KA6	RPS6KA6	RPS6KA6	1079	0.34	0.24	YES
6	GRM1	GRM1	GRM1	1519	0.28	0.25	YES
7	PRKCG	PRKCG	PRKCG	1565	0.28	0.29	YES
8	RAPGEF3	RAPGEF3	RAPGEF3	2288	0.22	0.28	YES
9	GRM5	GRM5	GRM5	2393	0.21	0.3	YES
10	GRIN2A	GRIN2A	GRIN2A	2435	0.21	0.33	YES
11	GRIA1	GRIA1	GRIA1	2442	0.21	0.36	YES
12	CACNA1C	CACNA1C	CACNA1C	2548	0.2	0.38	YES
13	PLCB4	PLCB4	PLCB4	2581	0.2	0.4	YES
14	GRIN2C	GRIN2C	GRIN2C	2701	0.19	0.42	YES
15	CAMK2A	CAMK2A	CAMK2A	2773	0.19	0.44	YES
16	ADCY8	ADCY8	ADCY8	2880	0.18	0.46	YES
17	CAMK4	CAMK4	CAMK4	4201	0.12	0.41	NO
18	CAMK2G	CAMK2G	CAMK2G	4325	0.12	0.42	NO
19	CREBBP	CREBBP	CREBBP	4938	0.096	0.4	NO
20	PPP3CA	PPP3CA	PPP3CA	5165	0.09	0.4	NO
21	CALM1	CALM1	CALM1	5734	0.076	0.38	NO
22	GRIN2D	GRIN2D	GRIN2D	5884	0.073	0.38	NO
23	PRKACA	PRKACA	PRKACA	5993	0.07	0.38	NO
24	PRKX	PRKX	PRKX	6173	0.066	0.38	NO
25	KRAS	KRAS	KRAS	6619	0.056	0.36	NO
26	CAMK2D	CAMK2D	CAMK2D	7324	0.044	0.33	NO
27	PPP3CB	PPP3CB	PPP3CB	7754	0.037	0.31	NO
28	GRIN1	GRIN1	GRIN1	7776	0.036	0.32	NO
29	MAP2K2	MAP2K2	MAP2K2	7827	0.035	0.32	NO
30	CALM3	CALM3	CALM3	7916	0.034	0.32	NO
31	EP300	EP300	EP300	7923	0.034	0.32	NO
32	PPP3R1	PPP3R1	PPP3R1	8236	0.029	0.31	NO
33	PPP1R12A	PPP1R12A	PPP1R12A	8927	0.019	0.27	NO
34	GRIA2	GRIA2	GRIA2	9016	0.018	0.27	NO
35	PRKACB	PRKACB	PRKACB	9119	0.016	0.27	NO
36	RPS6KA2	RPS6KA2	RPS6KA2	9215	0.015	0.26	NO
37	GNAQ	GNAQ	GNAQ	9307	0.014	0.26	NO
38	ITPR2	ITPR2	ITPR2	9402	0.012	0.26	NO
39	ITPR3	ITPR3	ITPR3	9776	0.0076	0.24	NO
40	PPP1CC	PPP1CC	PPP1CC	9852	0.0064	0.24	NO
41	ATF4	ATF4	ATF4	9860	0.0063	0.24	NO
42	MAPK1	MAPK1	MAPK1	10177	0.0018	0.22	NO
43	RAF1	RAF1	RAF1	10279	0.00052	0.21	NO
44	CALML6	CALML6	CALML6	10900	-0.0081	0.18	NO
45	PPP1CB	PPP1CB	PPP1CB	11761	-0.021	0.14	NO
46	BRAF	BRAF	BRAF	11891	-0.022	0.13	NO
47	ARAF	ARAF	ARAF	11967	-0.024	0.13	NO
48	CALM2	CALM2	CALM2	11968	-0.024	0.13	NO
49	NRAS	NRAS	NRAS	11996	-0.024	0.14	NO
50	HRAS	HRAS	HRAS	12025	-0.024	0.14	NO
51	RAP1B	RAP1B	RAP1B	12402	-0.03	0.12	NO
52	CHP2	CHP2	CHP2	12459	-0.031	0.12	NO
53	PLCB3	PLCB3	PLCB3	12765	-0.036	0.11	NO
54	PPP1CA	PPP1CA	PPP1CA	12820	-0.037	0.11	NO
55	ITPR1	ITPR1	ITPR1	13553	-0.05	0.077	NO
56	PPP3CC	PPP3CC	PPP3CC	13594	-0.051	0.082	NO
57	MAPK3	MAPK3	MAPK3	13791	-0.055	0.079	NO
58	MAP2K1	MAP2K1	MAP2K1	14261	-0.065	0.062	NO
59	PRKCA	PRKCA	PRKCA	14691	-0.075	0.048	NO
60	GRIN2B	GRIN2B	GRIN2B	15067	-0.084	0.039	NO
61	PLCB1	PLCB1	PLCB1	15180	-0.088	0.045	NO
62	PLCB2	PLCB2	PLCB2	15250	-0.089	0.053	NO
63	RPS6KA3	RPS6KA3	RPS6KA3	15433	-0.096	0.056	NO
64	RAP1A	RAP1A	RAP1A	15449	-0.096	0.069	NO
65	RPS6KA1	RPS6KA1	RPS6KA1	16244	-0.13	0.043	NO
66	CHP	CHP	CHP	17054	-0.19	0.024	NO
67	PRKCB	PRKCB	PRKCB	17708	-0.28	0.026	NO