Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	20.0	686.0	34.0	-0.273	0.014	1000.0	-1000.0	-0.062	-1000.0
Ephrin A  reverse signaling	20.0	146.0	7.0	-0.167	-0.0	1000.0	-1000.0	-0.031	-1000.0
TCGA08_retinoblastoma	18.0	146.0	8.0	-0.135	0.085	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	13.0	475.0	34.0	-0.288	0.014	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by the Hedgehog family	13.0	715.0	52.0	-0.296	0.17	1000.0	-1000.0	-0.077	-1000.0
IL4-mediated signaling events	12.0	1100.0	91.0	-0.76	0.683	1000.0	-1000.0	-0.16	-1000.0
p75(NTR)-mediated signaling	10.0	1373.0	125.0	-0.332	0.027	1000.0	-1000.0	-0.109	-1000.0
Glucocorticoid receptor regulatory network	10.0	1165.0	114.0	-0.718	0.347	1000.0	-1000.0	-0.08	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	445.0	44.0	-0.125	0.014	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling events	10.0	53.0	5.0	-0.11	0.014	1000.0	-1000.0	-0.041	-1000.0
amb2 Integrin signaling	9.0	746.0	82.0	-0.299	0.014	1000.0	-1000.0	-0.082	-1000.0
Signaling events regulated by Ret tyrosine kinase	9.0	795.0	82.0	-0.207	0.014	1000.0	-1000.0	-0.092	-1000.0
Endothelins	9.0	882.0	96.0	-0.249	0.014	1000.0	-1000.0	-0.086	-1000.0
Integrins in angiogenesis	9.0	827.0	84.0	-0.262	0.027	1000.0	-1000.0	-0.097	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	646.0	68.0	-0.38	0.081	1000.0	-1000.0	-0.124	-1000.0
IL23-mediated signaling events	9.0	560.0	60.0	-0.468	0.014	1000.0	-1000.0	-0.161	-1000.0
HIF-1-alpha transcription factor network	8.0	627.0	76.0	-0.309	0.025	1000.0	-1000.0	-0.136	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	372.0	46.0	-0.38	0.024	1000.0	-1000.0	-0.083	-1000.0
Reelin signaling pathway	8.0	491.0	56.0	-0.268	0.021	1000.0	-1000.0	-0.077	-1000.0
Ephrin B reverse signaling	8.0	417.0	48.0	-0.177	0.029	1000.0	-1000.0	-0.065	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	767.0	93.0	-0.162	0.077	1000.0	-1000.0	-0.082	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	250.0	31.0	-0.304	0.014	1000.0	-1000.0	-0.089	-1000.0
Caspase cascade in apoptosis	7.0	519.0	74.0	-0.136	0.067	1000.0	-1000.0	-0.04	-1000.0
IL12-mediated signaling events	7.0	658.0	87.0	-0.28	0.027	1000.0	-1000.0	-0.127	-1000.0
Thromboxane A2 receptor signaling	7.0	765.0	105.0	-0.191	0.054	1000.0	-1000.0	-0.06	-1000.0
BMP receptor signaling	7.0	577.0	81.0	-0.226	0.042	1000.0	-1000.0	-0.098	-1000.0
Glypican 1 network	7.0	336.0	48.0	-0.205	0.018	1000.0	-1000.0	-0.047	-1000.0
Nongenotropic Androgen signaling	7.0	365.0	52.0	-0.133	0.066	1000.0	-1000.0	-0.062	-1000.0
Wnt signaling	7.0	49.0	7.0	-0.096	0.014	1000.0	-1000.0	-0.025	-1000.0
BCR signaling pathway	7.0	706.0	99.0	-0.248	0.016	1000.0	-1000.0	-0.095	-1000.0
Syndecan-4-mediated signaling events	7.0	521.0	67.0	-0.169	0.017	1000.0	-1000.0	-0.099	-1000.0
LPA4-mediated signaling events	6.0	72.0	12.0	-0.097	0.017	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	518.0	85.0	-0.14	0.014	1000.0	-1000.0	-0.08	-1000.0
TCGA08_p53	6.0	42.0	7.0	-0.102	0.056	1000.0	-1000.0	-0.018	-1000.0
EPHB forward signaling	6.0	530.0	85.0	-0.146	0.089	1000.0	-1000.0	-0.095	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	456.0	76.0	-0.11	0.021	1000.0	-1000.0	-0.085	-1000.0
EGFR-dependent Endothelin signaling events	6.0	136.0	21.0	-0.125	0.021	1000.0	-1000.0	-0.065	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	826.0	120.0	-0.234	0.175	1000.0	-1000.0	-0.08	-1000.0
ErbB2/ErbB3 signaling events	5.0	338.0	65.0	-0.151	0.022	1000.0	-1000.0	-0.068	-1000.0
Coregulation of Androgen receptor activity	5.0	388.0	76.0	-0.158	0.024	1000.0	-1000.0	-0.04	-1000.0
ErbB4 signaling events	5.0	375.0	69.0	-0.196	0.158	1000.0	-1000.0	-0.097	-1000.0
Visual signal transduction: Cones	5.0	204.0	38.0	-0.083	0.014	1000.0	-1000.0	-0.059	-1000.0
Osteopontin-mediated events	5.0	196.0	38.0	-0.138	0.018	1000.0	-1000.0	-0.109	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	320.0	54.0	-0.195	0.029	1000.0	-1000.0	-0.1	-1000.0
Noncanonical Wnt signaling pathway	5.0	134.0	26.0	-0.112	0.014	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	5.0	145.0	26.0	-0.124	0.014	1000.0	-1000.0	-0.063	-1000.0
Glypican 2 network	5.0	22.0	4.0	-0.022	-0.021	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	734.0	125.0	-0.097	0.021	1000.0	-1000.0	-0.102	-1000.0
IL27-mediated signaling events	5.0	259.0	51.0	-0.174	0.071	1000.0	-1000.0	-0.084	-1000.0
IL6-mediated signaling events	5.0	426.0	75.0	-0.21	0.056	1000.0	-1000.0	-0.092	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	385.0	74.0	-0.157	0.063	1000.0	-1000.0	-0.091	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	502.0	88.0	-0.261	0.016	1000.0	-1000.0	-0.109	-1000.0
Visual signal transduction: Rods	5.0	278.0	52.0	-0.177	0.014	1000.0	-1000.0	-0.092	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.013	-1000.0
Syndecan-2-mediated signaling events	4.0	328.0	69.0	-0.139	0.036	1000.0	-1000.0	-0.05	-1000.0
Arf6 signaling events	4.0	307.0	62.0	-0.263	0.016	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by PTP1B	4.0	317.0	76.0	-0.158	0.025	1000.0	-1000.0	-0.083	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	272.0	61.0	-0.268	0.039	1000.0	-1000.0	-0.069	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	439.0	97.0	-0.138	0.034	1000.0	-1000.0	-0.081	-1000.0
PDGFR-alpha signaling pathway	4.0	181.0	44.0	-0.221	0.028	1000.0	-1000.0	-0.063	-1000.0
S1P1 pathway	4.0	157.0	36.0	-0.098	0.014	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	4.0	211.0	47.0	-0.259	0.028	1000.0	-1000.0	-0.043	-1000.0
Syndecan-3-mediated signaling events	4.0	158.0	35.0	-0.105	0.021	1000.0	-1000.0	-0.072	-1000.0
IGF1 pathway	4.0	264.0	57.0	-0.082	0.021	1000.0	-1000.0	-0.099	-1000.0
FOXM1 transcription factor network	4.0	204.0	51.0	-0.145	0.14	1000.0	-1000.0	-0.186	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	459.0	136.0	-0.226	0.222	1000.0	-1000.0	-0.069	-1000.0
BARD1 signaling events	3.0	197.0	57.0	-0.055	0.045	1000.0	-1000.0	-0.066	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	241.0	65.0	-0.245	0.071	1000.0	-1000.0	-0.065	-1000.0
Nectin adhesion pathway	3.0	243.0	63.0	-0.13	0.026	1000.0	-1000.0	-0.071	-1000.0
HIF-2-alpha transcription factor network	3.0	133.0	43.0	-0.127	0.023	1000.0	-1000.0	-0.086	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	49.0	15.0	-0.017	0.019	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	3.0	206.0	58.0	-0.143	0.02	1000.0	-1000.0	-0.076	-1000.0
IL2 signaling events mediated by PI3K	3.0	186.0	58.0	-0.094	0.036	1000.0	-1000.0	-0.085	-1000.0
Canonical Wnt signaling pathway	3.0	192.0	51.0	-0.268	0.052	1000.0	-1000.0	-0.061	-1000.0
LPA receptor mediated events	3.0	363.0	102.0	-0.145	0.039	1000.0	-1000.0	-0.092	-1000.0
IL2 signaling events mediated by STAT5	3.0	80.0	22.0	-0.069	0.015	1000.0	-1000.0	-0.04	-1000.0
VEGFR1 specific signals	3.0	185.0	56.0	-0.092	0.014	1000.0	-1000.0	-0.084	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	106.0	33.0	-0.138	0.026	1000.0	-1000.0	-0.061	-1000.0
Regulation of Androgen receptor activity	3.0	242.0	70.0	-0.315	0.027	1000.0	-1000.0	-0.068	-1000.0
Aurora B signaling	3.0	234.0	67.0	-0.128	0.014	1000.0	-1000.0	-0.075	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	59.0	28.0	-0.037	0.025	1000.0	-1000.0	-0.04	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	-0.008	0.002	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	44.0	17.0	-0.039	0.027	1000.0	-1000.0	-0.061	-1000.0
Cellular roles of Anthrax toxin	2.0	89.0	39.0	-0.065	0.018	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.021	0.0	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	2.0	155.0	68.0	-0.162	0.036	1000.0	-1000.0	-0.102	-1000.0
Signaling events mediated by HDAC Class III	2.0	99.0	40.0	-0.131	0.03	1000.0	-1000.0	-0.045	-1000.0
TRAIL signaling pathway	2.0	137.0	48.0	-0.04	0.031	1000.0	-1000.0	-0.067	-1000.0
IL1-mediated signaling events	2.0	160.0	62.0	-0.094	0.064	1000.0	-1000.0	-0.098	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	132.0	52.0	-0.153	0.034	1000.0	-1000.0	-0.06	-1000.0
Regulation of p38-alpha and p38-beta	2.0	133.0	54.0	-0.158	0.033	1000.0	-1000.0	-0.062	-1000.0
Regulation of Telomerase	2.0	285.0	102.0	-0.163	0.036	1000.0	-1000.0	-0.099	-1000.0
Plasma membrane estrogen receptor signaling	2.0	218.0	86.0	-0.073	0.04	1000.0	-1000.0	-0.074	-1000.0
S1P3 pathway	2.0	101.0	42.0	-0.095	0.021	1000.0	-1000.0	-0.034	-1000.0
Rapid glucocorticoid signaling	2.0	41.0	20.0	-0.05	0.014	1000.0	-1000.0	-0.041	-1000.0
PDGFR-beta signaling pathway	2.0	247.0	97.0	-0.087	0.023	1000.0	-1000.0	-0.093	-1000.0
E-cadherin signaling in keratinocytes	2.0	127.0	43.0	-0.11	0.016	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	191.0	78.0	-0.056	0.047	1000.0	-1000.0	-0.066	-1000.0
p38 MAPK signaling pathway	2.0	108.0	44.0	-0.149	0.027	1000.0	-1000.0	-0.071	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	49.0	17.0	-0.038	0.022	1000.0	-1000.0	-0.041	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.013	0.021	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	1.0	102.0	60.0	-0.125	0.042	1000.0	-1000.0	-0.068	-1000.0
Arf6 downstream pathway	1.0	47.0	43.0	-0.031	0.027	1000.0	-1000.0	-0.035	-1000.0
PLK1 signaling events	1.0	121.0	85.0	-0.031	0.026	1000.0	-1000.0	-0.047	-1000.0
Insulin-mediated glucose transport	1.0	43.0	32.0	-0.138	0.034	1000.0	-1000.0	-0.067	-1000.0
Ceramide signaling pathway	1.0	116.0	76.0	-0.073	0.034	1000.0	-1000.0	-0.062	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	62.0	37.0	-0.052	0.037	1000.0	-1000.0	-0.056	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.029	0.026	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	160.0	83.0	-0.147	0.05	1000.0	-1000.0	-0.081	-1000.0
FoxO family signaling	1.0	97.0	64.0	-0.138	0.103	1000.0	-1000.0	-0.071	-1000.0
Atypical NF-kappaB pathway	1.0	49.0	31.0	-0.046	0.029	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	66.0	45.0	-0.059	0.057	1000.0	-1000.0	-0.096	-1000.0
TCGA08_rtk_signaling	1.0	51.0	26.0	-0.056	0.041	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events	1.0	84.0	73.0	-0.158	0.041	1000.0	-1000.0	-0.069	-1000.0
Insulin Pathway	1.0	124.0	74.0	-0.133	0.031	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by PRL	1.0	62.0	34.0	-0.063	0.021	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	1.0	44.0	25.0	-0.029	0.021	1000.0	-1000.0	-0.048	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.009	0.045	1000.0	-1000.0	-0.06	-1000.0
Canonical NF-kappaB pathway	0.0	24.0	39.0	-0.024	0.079	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class II	0.0	53.0	75.0	-0.05	0.039	1000.0	-1000.0	-0.068	-1000.0
Circadian rhythm pathway	0.0	21.0	22.0	-0.011	0.038	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	0.0	30.0	55.0	-0.029	0.079	1000.0	-1000.0	-0.094	-1000.0
mTOR signaling pathway	0.0	37.0	53.0	-0.012	0.033	1000.0	-1000.0	-0.061	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	55.0	68.0	-0.138	0.054	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	0.0	40.0	49.0	-0.023	0.046	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class I	0.0	75.0	104.0	-0.05	0.042	1000.0	-1000.0	-0.069	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	28.0	36.0	-0.043	0.043	1000.0	-1000.0	-0.074	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	0.0	0.036	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	0.0	28.0	71.0	-0.046	0.047	1000.0	-1000.0	-0.077	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.004	0.038	1000.0	-1000.0	-0.046	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.015	1000.0	-1000.0	-0.063	-1000.0
Total	569	35507	7203	-19.1448992266	-994.172653819	131000	-131000	-9.09726459146	-131000