GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in READ-TP

Rectum Adenocarcinoma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in READ-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1P84B0P

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 193
Number of samples: 166
Original number of Gene Sets: 404
Maximum gene set size: 388

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 5 :[ clus1 ] 29
pheno.type: 2 - 5 :[ clus5 ] 61
pheno.type: 3 - 5 :[ clus2 ] 14
pheno.type: 4 - 5 :[ clus3 ] 34
pheno.type: 5 - 5 :[ clus4 ] 28

For the expression subtypes of 18106 genes in 167 samples, GSEA found enriched gene sets in each cluster using 166 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are BIOCARTA NO1 PATHWAY, BIOCARTA ALK PATHWAY, BIOCARTA AT1R PATHWAY, BIOCARTA BCR PATHWAY, BIOCARTA BIOPEPTIDES PATHWAY, BIOCARTA G1 PATHWAY, BIOCARTA HDAC PATHWAY, BIOCARTA EGF PATHWAY, BIOCARTA FCER1 PATHWAY, BIOCARTA GH PATHWAY

And common core enriched genes are ACTN2, ACTN3, VCL, PIK3CA, EGFR, ITGA1, ROCK1, FYN, APC, CD14

clus2

Top enriched gene sets are BIOCARTA BCR PATHWAY, BIOCARTA HDAC PATHWAY, BIOCARTA EGF PATHWAY, BIOCARTA FCER1 PATHWAY, BIOCARTA HIVNEF PATHWAY, BIOCARTA DEATH PATHWAY, BIOCARTA KERATINOCYTE PATHWAY, BIOCARTA PYK2 PATHWAY, BIOCARTA PPARA PATHWAY, BIOCARTA VIP PATHWAY

And common core enriched genes are MAPK8, PIK3CA, PIK3CG, PTEN, MAP3K1, RASA1, MAP2K1, MAPK1, MAPK3, PAK1

clus3

Top enriched gene sets are BIOCARTA FAS PATHWAY, BIOCARTA HIVNEF PATHWAY, BIOCARTA RACCYCD PATHWAY, BIOCARTA PYK2 PATHWAY, BIOCARTA TNFR1 PATHWAY, KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION, KEGG O GLYCAN BIOSYNTHESIS, KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES, KEGG PROPANOATE METABOLISM, KEGG BUTANOATE METABOLISM

And common core enriched genes are LSM3, LSM5, LSM6, NAA38, AARS2, DARS, DARS2, EARS2, EPRS, FARSB

clus4

Top enriched gene sets are BIOCARTA ERK PATHWAY, BIOCARTA DEATH PATHWAY, BIOCARTA RACCYCD PATHWAY, BIOCARTA CHREBP2 PATHWAY, BIOCARTA WNT PATHWAY, KEGG CITRATE CYCLE TCA CYCLE, KEGG CYSTEINE AND METHIONINE METABOLISM, KEGG LYSINE DEGRADATION, KEGG SELENOAMINO ACID METABOLISM, KEGG PROPANOATE METABOLISM

And common core enriched genes are PIPOX, LSM3, LSM5, LSM6, NAA38, AASDHPPT, AASS, ACAT1, BBOX1, OGDHL

clus5

Top enriched gene sets are BIOCARTA FMLP PATHWAY, KEGG GLYCOLYSIS GLUCONEOGENESIS, KEGG PENTOSE PHOSPHATE PATHWAY, KEGG FRUCTOSE AND MANNOSE METABOLISM, KEGG OXIDATIVE PHOSPHORYLATION, KEGG PYRIMIDINE METABOLISM, KEGG ARGININE AND PROLINE METABOLISM, KEGG TYROSINE METABOLISM, KEGG GLUTATHIONE METABOLISM, KEGG GLYCEROPHOSPHOLIPID METABOLISM

And common core enriched genes are TUBA1A, TUBA3D, TUBA8, TUBAL3, TUBB2A, TUBB3, TUBB4Q, TUBB8, C8G, ELANE

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA NO1 PATHWAY	29	genes.ES.table	0.51	1.3	0.14	0.25	0.98	0.28	0.14	0.24	0.19	0.006
BIOCARTA ALK PATHWAY	33	genes.ES.table	0.44	1.3	0.13	0.25	0.98	0.36	0.23	0.28	0.2	0.006
BIOCARTA AT1R PATHWAY	32	genes.ES.table	0.38	1.5	0.081	0.18	0.86	0.062	0.061	0.059	0.11	0.006
BIOCARTA BCR PATHWAY	33	genes.ES.table	0.53	1.5	0.079	0.16	0.82	0.39	0.3	0.28	0.095	0.004
BIOCARTA BIOPEPTIDES PATHWAY	40	genes.ES.table	0.44	1.6	0.03	0.15	0.77	0.28	0.2	0.22	0.088	0.007
BIOCARTA G1 PATHWAY	27	genes.ES.table	0.48	1.6	0.039	0.15	0.77	0.15	0.097	0.13	0.085	0.007
BIOCARTA HDAC PATHWAY	26	genes.ES.table	0.49	1.5	0.12	0.2	0.9	0.54	0.37	0.34	0.13	0.006
BIOCARTA EGF PATHWAY	30	genes.ES.table	0.47	1.6	0.061	0.17	0.74	0.7	0.46	0.38	0.092	0.012
BIOCARTA FCER1 PATHWAY	37	genes.ES.table	0.54	1.6	0.062	0.15	0.79	0.43	0.31	0.3	0.092	0.004
BIOCARTA GH PATHWAY	25	genes.ES.table	0.49	1.5	0.071	0.17	0.86	0.28	0.18	0.23	0.11	0.006

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	LY96	LY96	LY96	307	0.65	0.18	YES
2	GJA1	GJA1	GJA1	1882	0.3	0.18	YES
3	LEF1	LEF1	LEF1	2100	0.28	0.26	YES
4	TLR4	TLR4	TLR4	2160	0.27	0.34	YES
5	FZD1	FZD1	FZD1	2219	0.26	0.41	YES
6	GNAI1	GNAI1	GNAI1	2340	0.25	0.48	YES
7	CD14	CD14	CD14	3055	0.19	0.5	YES
8	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.55	YES
9	EIF2AK2	EIF2AK2	EIF2AK2	3418	0.16	0.58	YES
10	APC	APC	APC	3508	0.16	0.63	YES
11	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.54	NO
12	CCND1	CCND1	CCND1	6399	0.066	0.51	NO
13	WNT1	WNT1	WNT1	7036	0.054	0.49	NO
14	NFKB1	NFKB1	NFKB1	8473	0.029	0.42	NO
15	GSK3B	GSK3B	GSK3B	8561	0.028	0.43	NO
16	RELA	RELA	RELA	9233	0.016	0.39	NO
17	CTNNB1	CTNNB1	CTNNB1	9483	0.012	0.38	NO
18	MYD88	MYD88	MYD88	10056	0.0023	0.35	NO
19	PPP2CA	PPP2CA	PPP2CA	10802	-0.0099	0.31	NO
20	TIRAP	TIRAP	TIRAP	10821	-0.01	0.32	NO
21	PDPK1	PDPK1	PDPK1	10945	-0.013	0.31	NO
22	AKT1	AKT1	AKT1	11433	-0.022	0.29	NO
23	AXIN1	AXIN1	AXIN1	12051	-0.032	0.27	NO
24	IRAK1	IRAK1	IRAK1	12896	-0.048	0.24	NO
25	LBP	LBP	LBP	14237	-0.079	0.19	NO
26	DVL1	DVL1	DVL1	14623	-0.091	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FGF14	FGF14	FGF14	10	0.95	0.03	YES
2	FGF1	FGF1	FGF1	94	0.78	0.05	YES
3	CHRM2	CHRM2	CHRM2	102	0.77	0.074	YES
4	FGF7	FGF7	FGF7	121	0.76	0.097	YES
5	FGF2	FGF2	FGF2	303	0.65	0.11	YES
6	FGF10	FGF10	FGF10	355	0.62	0.12	YES
7	FGF5	FGF5	FGF5	436	0.59	0.14	YES
8	ITGAM	ITGAM	ITGAM	485	0.57	0.15	YES
9	PDGFC	PDGFC	PDGFC	628	0.52	0.16	YES
10	ITGA10	ITGA10	ITGA10	664	0.51	0.18	YES
11	MRAS	MRAS	MRAS	758	0.49	0.19	YES
12	ITGA11	ITGA11	ITGA11	849	0.47	0.2	YES
13	ACTN2	ACTN2	ACTN2	892	0.46	0.21	YES
14	PAK3	PAK3	PAK3	904	0.46	0.22	YES
15	MYLK	MYLK	MYLK	932	0.45	0.24	YES
16	CFL2	CFL2	CFL2	1013	0.43	0.24	YES
17	ITGAX	ITGAX	ITGAX	1141	0.41	0.25	YES
18	TIAM1	TIAM1	TIAM1	1196	0.4	0.26	YES
19	MYH10	MYH10	MYH10	1238	0.39	0.27	YES
20	ARHGEF6	ARHGEF6	ARHGEF6	1240	0.39	0.28	YES
21	RDX	RDX	RDX	1287	0.38	0.29	YES
22	FGF12	FGF12	FGF12	1333	0.38	0.3	YES
23	FGF13	FGF13	FGF13	1398	0.36	0.31	YES
24	ITGA4	ITGA4	ITGA4	1438	0.36	0.32	YES
25	PIK3CG	PIK3CG	PIK3CG	1455	0.36	0.33	YES
26	MYL9	MYL9	MYL9	1456	0.36	0.34	YES
27	FN1	FN1	FN1	1486	0.35	0.35	YES
28	FGFR1	FGFR1	FGFR1	1521	0.35	0.36	YES
29	ITGB3	ITGB3	ITGB3	1559	0.34	0.37	YES
30	NCKAP1L	NCKAP1L	NCKAP1L	1560	0.34	0.38	YES
31	PIK3R5	PIK3R5	PIK3R5	1567	0.34	0.39	YES
32	WAS	WAS	WAS	1742	0.32	0.39	YES
33	ITGA7	ITGA7	ITGA7	1743	0.32	0.4	YES
34	PDGFD	PDGFD	PDGFD	1801	0.31	0.41	YES
35	PDGFRB	PDGFRB	PDGFRB	1803	0.31	0.42	YES
36	ITGAL	ITGAL	ITGAL	1812	0.31	0.43	YES
37	ITGA5	ITGA5	ITGA5	1904	0.3	0.43	YES
38	CHRM4	CHRM4	CHRM4	1963	0.3	0.44	YES
39	ITGB2	ITGB2	ITGB2	1968	0.29	0.45	YES
40	F2R	F2R	F2R	1997	0.29	0.45	YES
41	FGF9	FGF9	FGF9	2018	0.29	0.46	YES
42	PIK3CD	PIK3CD	PIK3CD	2163	0.27	0.46	YES
43	ITGAV	ITGAV	ITGAV	2189	0.27	0.47	YES
44	FGFR2	FGFR2	FGFR2	2196	0.27	0.48	YES
45	ITGB8	ITGB8	ITGB8	2197	0.27	0.49	YES
46	ITGA1	ITGA1	ITGA1	2201	0.27	0.49	YES
47	TIAM2	TIAM2	TIAM2	2237	0.26	0.5	YES
48	PDGFRA	PDGFRA	PDGFRA	2405	0.24	0.5	YES
49	MSN	MSN	MSN	2664	0.22	0.49	YES
50	WASF1	WASF1	WASF1	2780	0.21	0.49	YES
51	PDGFB	PDGFB	PDGFB	2787	0.21	0.5	YES
52	CD14	CD14	CD14	3055	0.19	0.49	YES
53	PIP4K2A	PIP4K2A	PIP4K2A	3093	0.18	0.49	YES
54	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.5	YES
55	CHRM5	CHRM5	CHRM5	3315	0.17	0.49	YES
56	ENAH	ENAH	ENAH	3464	0.16	0.49	YES
57	BDKRB1	BDKRB1	BDKRB1	3499	0.16	0.49	YES
58	APC	APC	APC	3508	0.16	0.5	YES
59	PFN4	PFN4	PFN4	3598	0.15	0.5	YES
60	ROCK1	ROCK1	ROCK1	3615	0.15	0.5	YES
61	MYLK3	MYLK3	MYLK3	3679	0.15	0.5	YES
62	PDGFA	PDGFA	PDGFA	3713	0.15	0.5	YES
63	VCL	VCL	VCL	3750	0.15	0.51	YES
64	PIKFYVE	PIKFYVE	PIKFYVE	3809	0.14	0.51	YES
65	SSH1	SSH1	SSH1	3829	0.14	0.51	YES
66	ITGA9	ITGA9	ITGA9	3837	0.14	0.52	YES
67	ACTN3	ACTN3	ACTN3	3908	0.14	0.52	YES
68	ARHGEF4	ARHGEF4	ARHGEF4	3939	0.14	0.52	YES
69	VAV1	VAV1	VAV1	3960	0.14	0.52	YES
70	FGF11	FGF11	FGF11	4005	0.14	0.52	YES
71	SOS2	SOS2	SOS2	4099	0.13	0.52	YES
72	SCIN	SCIN	SCIN	4139	0.13	0.52	YES
73	PPP1R12A	PPP1R12A	PPP1R12A	4186	0.13	0.53	YES
74	ITGB5	ITGB5	ITGB5	4254	0.12	0.53	YES
75	EGFR	EGFR	EGFR	4305	0.12	0.53	YES
76	ABI2	ABI2	ABI2	4343	0.12	0.53	YES
77	ITGB1	ITGB1	ITGB1	4461	0.12	0.53	NO
78	SOS1	SOS1	SOS1	4575	0.11	0.52	NO
79	DOCK1	DOCK1	DOCK1	4784	0.11	0.52	NO
80	ACTN1	ACTN1	ACTN1	4867	0.1	0.52	NO
81	GNG12	GNG12	GNG12	4942	0.1	0.51	NO
82	ROCK2	ROCK2	ROCK2	4986	0.1	0.52	NO
83	WASL	WASL	WASL	5071	0.099	0.51	NO
84	BRAF	BRAF	BRAF	5099	0.098	0.52	NO
85	ARHGEF12	ARHGEF12	ARHGEF12	5169	0.096	0.51	NO
86	GSN	GSN	GSN	5335	0.091	0.51	NO
87	DIAPH2	DIAPH2	DIAPH2	5440	0.089	0.5	NO
88	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.5	NO
89	PIK3R3	PIK3R3	PIK3R3	5593	0.084	0.5	NO
90	FGF18	FGF18	FGF18	5657	0.082	0.5	NO
91	ITGA8	ITGA8	ITGA8	5676	0.082	0.5	NO
92	PPP1CB	PPP1CB	PPP1CB	5722	0.081	0.5	NO
93	INSRR	INSRR	INSRR	5936	0.076	0.49	NO
94	MYH9	MYH9	MYH9	5940	0.076	0.5	NO
95	PAK2	PAK2	PAK2	6049	0.073	0.49	NO
96	GNA12	GNA12	GNA12	6074	0.073	0.49	NO
97	GNA13	GNA13	GNA13	6219	0.07	0.49	NO
98	IQGAP1	IQGAP1	IQGAP1	6290	0.068	0.48	NO
99	SSH2	SSH2	SSH2	6412	0.066	0.48	NO
100	ARPC3	ARPC3	ARPC3	6577	0.062	0.47	NO
101	KRAS	KRAS	KRAS	6580	0.062	0.48	NO
102	PFN2	PFN2	PFN2	6599	0.062	0.48	NO
103	LIMK1	LIMK1	LIMK1	6640	0.061	0.48	NO
104	PIK3CB	PIK3CB	PIK3CB	6898	0.056	0.46	NO
105	NRAS	NRAS	NRAS	6951	0.056	0.46	NO
106	VAV2	VAV2	VAV2	6981	0.055	0.46	NO
107	NCKAP1	NCKAP1	NCKAP1	7046	0.054	0.46	NO
108	BDKRB2	BDKRB2	BDKRB2	7119	0.052	0.46	NO
109	CDC42	CDC42	CDC42	7140	0.052	0.46	NO
110	WASF2	WASF2	WASF2	7228	0.05	0.46	NO
111	PTK2	PTK2	PTK2	7335	0.048	0.45	NO
112	PIP4K2B	PIP4K2B	PIP4K2B	7345	0.048	0.45	NO
113	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.44	NO
114	PIP5K1C	PIP5K1C	PIP5K1C	7507	0.045	0.44	NO
115	ARHGEF7	ARHGEF7	ARHGEF7	7528	0.045	0.45	NO
116	MAPK1	MAPK1	MAPK1	7616	0.043	0.44	NO
117	ITGA2	ITGA2	ITGA2	7649	0.043	0.44	NO
118	FGF19	FGF19	FGF19	7697	0.042	0.44	NO
119	RAC1	RAC1	RAC1	7768	0.04	0.44	NO
120	MYL2	MYL2	MYL2	7799	0.04	0.44	NO
121	ARPC5	ARPC5	ARPC5	7915	0.038	0.43	NO
122	PIP5K1A	PIP5K1A	PIP5K1A	8138	0.034	0.42	NO
123	RHOA	RHOA	RHOA	8291	0.032	0.41	NO
124	BAIAP2	BAIAP2	BAIAP2	8355	0.031	0.41	NO
125	MYL12A	MYL12A	MYL12A	8710	0.025	0.39	NO
126	VAV3	VAV3	VAV3	8800	0.023	0.39	NO
127	PAK1	PAK1	PAK1	8925	0.021	0.38	NO
128	CRKL	CRKL	CRKL	8977	0.02	0.38	NO
129	EZR	EZR	EZR	9378	0.014	0.36	NO
130	DIAPH1	DIAPH1	DIAPH1	9515	0.011	0.35	NO
131	ITGAD	ITGAD	ITGAD	9527	0.011	0.35	NO
132	FGD1	FGD1	FGD1	9607	0.0099	0.35	NO
133	CRK	CRK	CRK	9611	0.0098	0.35	NO
134	ARPC2	ARPC2	ARPC2	9813	0.0061	0.34	NO
135	MYLK2	MYLK2	MYLK2	9819	0.006	0.34	NO
136	RAC2	RAC2	RAC2	9895	0.0047	0.33	NO
137	GRLF1	GRLF1	GRLF1	9916	0.0044	0.33	NO
138	ITGB6	ITGB6	ITGB6	9986	0.0034	0.33	NO
139	PXN	PXN	PXN	10057	0.0022	0.32	NO
140	RAF1	RAF1	RAF1	10109	0.0014	0.32	NO
141	ITGB7	ITGB7	ITGB7	10154	0.00058	0.32	NO
142	ARPC4	ARPC4	ARPC4	10313	-0.002	0.31	NO
143	CYFIP1	CYFIP1	CYFIP1	10326	-0.0022	0.31	NO
144	ACTB	ACTB	ACTB	10373	-0.0029	0.3	NO
145	IQGAP2	IQGAP2	IQGAP2	10384	-0.0032	0.3	NO
146	PPP1CC	PPP1CC	PPP1CC	10433	-0.004	0.3	NO
147	ACTN4	ACTN4	ACTN4	10523	-0.0055	0.3	NO
148	ARHGEF1	ARHGEF1	ARHGEF1	10741	-0.0091	0.28	NO
149	RRAS	RRAS	RRAS	10831	-0.011	0.28	NO
150	PIP4K2C	PIP4K2C	PIP4K2C	11063	-0.015	0.27	NO
151	SLC9A1	SLC9A1	SLC9A1	11165	-0.017	0.26	NO
152	CFL1	CFL1	CFL1	11218	-0.018	0.26	NO
153	ITGAE	ITGAE	ITGAE	11372	-0.02	0.25	NO
154	ITGA6	ITGA6	ITGA6	11479	-0.022	0.25	NO
155	LIMK2	LIMK2	LIMK2	11508	-0.023	0.25	NO
156	FGF23	FGF23	FGF23	11545	-0.024	0.25	NO
157	ARPC1B	ARPC1B	ARPC1B	11669	-0.026	0.24	NO
158	DIAPH3	DIAPH3	DIAPH3	11737	-0.027	0.24	NO
159	PIP5K1B	PIP5K1B	PIP5K1B	11800	-0.028	0.23	NO
160	MYH14	MYH14	MYH14	12103	-0.033	0.22	NO
161	FGF3	FGF3	FGF3	12139	-0.034	0.22	NO
162	SSH3	SSH3	SSH3	12148	-0.034	0.22	NO
163	BCAR1	BCAR1	BCAR1	12352	-0.038	0.21	NO
164	FGF20	FGF20	FGF20	12370	-0.038	0.21	NO
165	FGD3	FGD3	FGD3	12467	-0.04	0.2	NO
166	GIT1	GIT1	GIT1	12511	-0.041	0.2	NO
167	MAPK3	MAPK3	MAPK3	12556	-0.042	0.2	NO
168	ARPC1A	ARPC1A	ARPC1A	12595	-0.042	0.2	NO
169	ITGB4	ITGB4	ITGB4	12772	-0.045	0.19	NO
170	ACTG1	ACTG1	ACTG1	12783	-0.046	0.19	NO
171	ITGA3	ITGA3	ITGA3	12822	-0.046	0.19	NO
172	MYL12B	MYL12B	MYL12B	12843	-0.047	0.19	NO
173	TMSL3	TMSL3	TMSL3	12874	-0.047	0.19	NO
174	RRAS2	RRAS2	RRAS2	12925	-0.048	0.19	NO
175	TMSB4Y	TMSB4Y	TMSB4Y	13036	-0.051	0.19	NO
176	PAK4	PAK4	PAK4	13193	-0.054	0.18	NO
177	EGF	EGF	EGF	13212	-0.055	0.18	NO
178	CSK	CSK	CSK	13327	-0.058	0.18	NO
179	CYFIP2	CYFIP2	CYFIP2	13332	-0.058	0.18	NO
180	ARPC5L	ARPC5L	ARPC5L	13346	-0.058	0.18	NO
181	PFN1	PFN1	PFN1	13606	-0.064	0.17	NO
182	PPP1CA	PPP1CA	PPP1CA	13639	-0.064	0.17	NO
183	PAK6	PAK6	PAK6	13717	-0.066	0.16	NO
184	IQGAP3	IQGAP3	IQGAP3	13724	-0.066	0.17	NO
185	PIK3R2	PIK3R2	PIK3R2	14099	-0.075	0.15	NO
186	ITGA2B	ITGA2B	ITGA2B	14854	-0.098	0.11	NO
187	CHRM1	CHRM1	CHRM1	14856	-0.098	0.11	NO
188	MAP2K2	MAP2K2	MAP2K2	15004	-0.1	0.11	NO
189	FGF17	FGF17	FGF17	15020	-0.1	0.11	NO
190	ARAF	ARAF	ARAF	15092	-0.11	0.11	NO
191	FGF21	FGF21	FGF21	15096	-0.11	0.11	NO
192	RAC3	RAC3	RAC3	15589	-0.13	0.088	NO
193	FGF8	FGF8	FGF8	15845	-0.14	0.078	NO
194	CHRM3	CHRM3	CHRM3	15934	-0.14	0.078	NO
195	MYL5	MYL5	MYL5	16032	-0.15	0.077	NO
196	F2	F2	F2	16097	-0.15	0.078	NO
197	FGFR4	FGFR4	FGFR4	16591	-0.19	0.057	NO
198	FGFR3	FGFR3	FGFR3	17012	-0.23	0.04	NO
199	APC2	APC2	APC2	17250	-0.27	0.036	NO
200	MYLPF	MYLPF	MYLPF	17605	-0.35	0.027	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACTN2	ACTN2	ACTN2	892	0.46	0.014	YES
2	SNAI2	SNAI2	SNAI2	958	0.45	0.072	YES
3	CTNNA3	CTNNA3	CTNNA3	1048	0.43	0.12	YES
4	SORBS1	SORBS1	SORBS1	1483	0.35	0.15	YES
5	FGFR1	FGFR1	FGFR1	1521	0.35	0.2	YES
6	PTPRM	PTPRM	PTPRM	1693	0.32	0.23	YES
7	WAS	WAS	WAS	1742	0.32	0.27	YES
8	WASF3	WASF3	WASF3	1749	0.32	0.32	YES
9	LEF1	LEF1	LEF1	2100	0.28	0.34	YES
10	TCF7L1	TCF7L1	TCF7L1	2487	0.24	0.35	YES
11	WASF1	WASF1	WASF1	2780	0.21	0.36	YES
12	TGFBR1	TGFBR1	TGFBR1	3089	0.19	0.37	YES
13	FYN	FYN	FYN	3108	0.18	0.39	YES
14	VCL	VCL	VCL	3750	0.15	0.38	YES
15	ACTN3	ACTN3	ACTN3	3908	0.14	0.39	YES
16	TGFBR2	TGFBR2	TGFBR2	4234	0.13	0.39	YES
17	EGFR	EGFR	EGFR	4305	0.12	0.4	YES
18	FER	FER	FER	4380	0.12	0.41	YES
19	ACTN1	ACTN1	ACTN1	4867	0.1	0.4	YES
20	WASL	WASL	WASL	5071	0.099	0.4	YES
21	SNAI1	SNAI1	SNAI1	5375	0.09	0.4	YES
22	IGF1R	IGF1R	IGF1R	5477	0.087	0.4	YES
23	TJP1	TJP1	TJP1	5559	0.085	0.41	YES
24	CTNNA2	CTNNA2	CTNNA2	5798	0.079	0.41	YES
25	LMO7	LMO7	LMO7	5827	0.078	0.42	YES
26	EP300	EP300	EP300	6024	0.074	0.42	YES
27	SMAD2	SMAD2	SMAD2	6193	0.071	0.42	YES
28	MET	MET	MET	6251	0.069	0.42	YES
29	IQGAP1	IQGAP1	IQGAP1	6290	0.068	0.43	YES
30	PTPRJ	PTPRJ	PTPRJ	6514	0.064	0.43	YES
31	PTPRB	PTPRB	PTPRB	6570	0.062	0.43	YES
32	SMAD4	SMAD4	SMAD4	6621	0.061	0.44	YES
33	YES1	YES1	YES1	6888	0.057	0.43	YES
34	MAP3K7	MAP3K7	MAP3K7	7063	0.053	0.43	YES
35	CDC42	CDC42	CDC42	7140	0.052	0.43	YES
36	WASF2	WASF2	WASF2	7228	0.05	0.44	YES
37	CSNK2A1	CSNK2A1	CSNK2A1	7321	0.048	0.44	YES
38	SSX2IP	SSX2IP	SSX2IP	7361	0.048	0.44	YES
39	MLLT4	MLLT4	MLLT4	7395	0.047	0.45	YES
40	INSR	INSR	INSR	7439	0.046	0.45	YES
41	MAPK1	MAPK1	MAPK1	7616	0.043	0.45	YES
42	CREBBP	CREBBP	CREBBP	7651	0.042	0.45	YES
43	SMAD3	SMAD3	SMAD3	7666	0.042	0.46	YES
44	RAC1	RAC1	RAC1	7768	0.04	0.46	NO
45	CTNND1	CTNND1	CTNND1	8239	0.033	0.43	NO
46	RHOA	RHOA	RHOA	8291	0.032	0.44	NO
47	BAIAP2	BAIAP2	BAIAP2	8355	0.031	0.44	NO
48	NLK	NLK	NLK	8780	0.024	0.42	NO
49	TCF7	TCF7	TCF7	8941	0.021	0.41	NO
50	PARD3	PARD3	PARD3	9004	0.02	0.41	NO
51	CTNNB1	CTNNB1	CTNNB1	9483	0.012	0.38	NO
52	CDH1	CDH1	CDH1	9848	0.0056	0.36	NO
53	RAC2	RAC2	RAC2	9895	0.0047	0.36	NO
54	CTNNA1	CTNNA1	CTNNA1	9956	0.0038	0.36	NO
55	PTPN1	PTPN1	PTPN1	10052	0.0023	0.36	NO
56	ACTB	ACTB	ACTB	10373	-0.0029	0.34	NO
57	PVRL3	PVRL3	PVRL3	10489	-0.005	0.33	NO
58	TCF7L2	TCF7L2	TCF7L2	10507	-0.0054	0.33	NO
59	ACP1	ACP1	ACP1	10521	-0.0055	0.33	NO
60	ACTN4	ACTN4	ACTN4	10523	-0.0055	0.33	NO
61	PTPN6	PTPN6	PTPN6	10987	-0.013	0.31	NO
62	ERBB2	ERBB2	ERBB2	11296	-0.019	0.29	NO
63	PTPRF	PTPRF	PTPRF	11306	-0.019	0.3	NO
64	SRC	SRC	SRC	11558	-0.024	0.28	NO
65	FARP2	FARP2	FARP2	12476	-0.04	0.24	NO
66	MAPK3	MAPK3	MAPK3	12556	-0.042	0.24	NO
67	CSNK2A2	CSNK2A2	CSNK2A2	12738	-0.045	0.24	NO
68	ACTG1	ACTG1	ACTG1	12783	-0.046	0.24	NO
69	CSNK2B	CSNK2B	CSNK2B	12956	-0.049	0.24	NO
70	PVRL1	PVRL1	PVRL1	13041	-0.051	0.24	NO
71	PVRL2	PVRL2	PVRL2	13684	-0.065	0.21	NO
72	PVRL4	PVRL4	PVRL4	14747	-0.094	0.17	NO
73	RAC3	RAC3	RAC3	15589	-0.13	0.14	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TNS1	TNS1	TNS1	791	0.48	0.072	YES
2	ACTN2	ACTN2	ACTN2	892	0.46	0.18	YES
3	PPP1R12B	PPP1R12B	PPP1R12B	1685	0.33	0.21	YES
4	ITGA1	ITGA1	ITGA1	2201	0.27	0.25	YES
5	CAV1	CAV1	CAV1	2233	0.26	0.31	YES
6	FYN	FYN	FYN	3108	0.18	0.31	YES
7	CAPNS2	CAPNS2	CAPNS2	3162	0.18	0.35	YES
8	ROCK1	ROCK1	ROCK1	3615	0.15	0.36	YES
9	VCL	VCL	VCL	3750	0.15	0.39	YES
10	ACTN3	ACTN3	ACTN3	3908	0.14	0.41	YES
11	RAP1A	RAP1A	RAP1A	4091	0.13	0.43	YES
12	ITGB1	ITGB1	ITGB1	4461	0.12	0.44	YES
13	SOS1	SOS1	SOS1	4575	0.11	0.46	YES
14	ACTN1	ACTN1	ACTN1	4867	0.1	0.47	YES
15	ACTA1	ACTA1	ACTA1	5191	0.095	0.48	YES
16	RAPGEF1	RAPGEF1	RAPGEF1	5260	0.093	0.5	YES
17	JUN	JUN	JUN	7148	0.052	0.4	NO
18	SHC1	SHC1	SHC1	7250	0.05	0.41	NO
19	PTK2	PTK2	PTK2	7335	0.048	0.42	NO
20	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.42	NO
21	MAPK1	MAPK1	MAPK1	7616	0.043	0.42	NO
22	ZYX	ZYX	ZYX	8040	0.036	0.41	NO
23	RHOA	RHOA	RHOA	8291	0.032	0.4	NO
24	CRKL	CRKL	CRKL	8977	0.02	0.37	NO
25	GRB2	GRB2	GRB2	8992	0.02	0.37	NO
26	MAPK8	MAPK8	MAPK8	9791	0.0065	0.33	NO
27	PXN	PXN	PXN	10057	0.0022	0.32	NO
28	RAF1	RAF1	RAF1	10109	0.0014	0.32	NO
29	SRC	SRC	SRC	11558	-0.024	0.24	NO
30	CAPN1	CAPN1	CAPN1	12211	-0.035	0.21	NO
31	BCAR1	BCAR1	BCAR1	12352	-0.038	0.21	NO
32	MAPK3	MAPK3	MAPK3	12556	-0.042	0.21	NO
33	BCR	BCR	BCR	13319	-0.058	0.18	NO
34	CSK	CSK	CSK	13327	-0.058	0.2	NO
35	CAPNS1	CAPNS1	CAPNS1	13989	-0.072	0.18	NO
36	HRAS	HRAS	HRAS	14840	-0.097	0.16	NO
37	MAP2K2	MAP2K2	MAP2K2	15004	-0.1	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	THBS4	THBS4	THBS4	9	0.97	0.027	YES
2	IGF1	IGF1	IGF1	186	0.71	0.038	YES
3	COMP	COMP	COMP	213	0.69	0.056	YES
4	COL11A1	COL11A1	COL11A1	336	0.63	0.067	YES
5	IBSP	IBSP	IBSP	468	0.57	0.076	YES
6	VEGFC	VEGFC	VEGFC	474	0.57	0.092	YES
7	THBS2	THBS2	THBS2	478	0.57	0.11	YES
8	SPP1	SPP1	SPP1	484	0.57	0.12	YES
9	RELN	RELN	RELN	495	0.56	0.14	YES
10	SHC4	SHC4	SHC4	504	0.56	0.16	YES
11	HGF	HGF	HGF	518	0.56	0.17	YES
12	AKT3	AKT3	AKT3	569	0.54	0.18	YES
13	MAPK10	MAPK10	MAPK10	600	0.53	0.2	YES
14	TNN	TNN	TNN	603	0.53	0.21	YES
15	PDGFC	PDGFC	PDGFC	628	0.52	0.23	YES
16	ITGA10	ITGA10	ITGA10	664	0.51	0.24	YES
17	TNXB	TNXB	TNXB	691	0.5	0.25	YES
18	LAMA2	LAMA2	LAMA2	748	0.49	0.26	YES
19	ITGA11	ITGA11	ITGA11	849	0.47	0.27	YES
20	ACTN2	ACTN2	ACTN2	892	0.46	0.28	YES
21	PAK3	PAK3	PAK3	904	0.46	0.29	YES
22	MYLK	MYLK	MYLK	932	0.45	0.3	YES
23	PRKCB	PRKCB	PRKCB	1108	0.41	0.31	YES
24	TNC	TNC	TNC	1144	0.41	0.32	YES
25	FLNC	FLNC	FLNC	1181	0.4	0.33	YES
26	COL6A6	COL6A6	COL6A6	1281	0.38	0.33	YES
27	COL4A4	COL4A4	COL4A4	1383	0.37	0.34	YES
28	COL5A2	COL5A2	COL5A2	1411	0.36	0.34	YES
29	ITGA4	ITGA4	ITGA4	1438	0.36	0.35	YES
30	PIK3CG	PIK3CG	PIK3CG	1455	0.36	0.36	YES
31	MYL9	MYL9	MYL9	1456	0.36	0.37	YES
32	FN1	FN1	FN1	1486	0.35	0.38	YES
33	ITGB3	ITGB3	ITGB3	1559	0.34	0.39	YES
34	PIK3R5	PIK3R5	PIK3R5	1567	0.34	0.4	YES
35	COL6A3	COL6A3	COL6A3	1647	0.33	0.4	YES
36	ITGA7	ITGA7	ITGA7	1743	0.32	0.41	YES
37	FIGF	FIGF	FIGF	1751	0.32	0.42	YES
38	PDGFD	PDGFD	PDGFD	1801	0.31	0.42	YES
39	PDGFRB	PDGFRB	PDGFRB	1803	0.31	0.43	YES
40	COL5A1	COL5A1	COL5A1	1855	0.3	0.44	YES
41	FLT4	FLT4	FLT4	1880	0.3	0.44	YES
42	ITGA5	ITGA5	ITGA5	1904	0.3	0.45	YES
43	COL1A2	COL1A2	COL1A2	1953	0.3	0.46	YES
44	COL3A1	COL3A1	COL3A1	1999	0.29	0.46	YES
45	PARVG	PARVG	PARVG	2003	0.29	0.47	YES
46	COL5A3	COL5A3	COL5A3	2052	0.28	0.48	YES
47	LAMA4	LAMA4	LAMA4	2118	0.28	0.48	YES
48	COL1A1	COL1A1	COL1A1	2140	0.27	0.49	YES
49	PIK3CD	PIK3CD	PIK3CD	2163	0.27	0.49	YES
50	ITGAV	ITGAV	ITGAV	2189	0.27	0.5	YES
51	KDR	KDR	KDR	2192	0.27	0.51	YES
52	ITGB8	ITGB8	ITGB8	2197	0.27	0.51	YES
53	ITGA1	ITGA1	ITGA1	2201	0.27	0.52	YES
54	CAV1	CAV1	CAV1	2233	0.26	0.53	YES
55	CAV2	CAV2	CAV2	2285	0.26	0.53	YES
56	THBS1	THBS1	THBS1	2321	0.25	0.54	YES
57	TNR	TNR	TNR	2384	0.25	0.54	YES
58	PDGFRA	PDGFRA	PDGFRA	2405	0.24	0.55	YES
59	FLNA	FLNA	FLNA	2417	0.24	0.55	YES
60	FLT1	FLT1	FLT1	2501	0.24	0.56	YES
61	COL6A1	COL6A1	COL6A1	2629	0.22	0.55	YES
62	COL6A2	COL6A2	COL6A2	2660	0.22	0.56	YES
63	BCL2	BCL2	BCL2	2698	0.22	0.56	YES
64	PDGFB	PDGFB	PDGFB	2787	0.21	0.56	YES
65	BIRC3	BIRC3	BIRC3	2903	0.2	0.56	YES
66	THBS3	THBS3	THBS3	2978	0.19	0.56	YES
67	COL4A1	COL4A1	COL4A1	2988	0.19	0.57	YES
68	COL4A2	COL4A2	COL4A2	2998	0.19	0.57	YES
69	LAMB2	LAMB2	LAMB2	3057	0.19	0.58	YES
70	FYN	FYN	FYN	3108	0.18	0.58	YES
71	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.58	YES
72	VTN	VTN	VTN	3301	0.17	0.58	YES
73	LAMC1	LAMC1	LAMC1	3385	0.16	0.58	YES
74	VWF	VWF	VWF	3504	0.16	0.58	YES
75	ROCK1	ROCK1	ROCK1	3615	0.15	0.57	YES
76	MYLK3	MYLK3	MYLK3	3679	0.15	0.58	YES
77	PDGFA	PDGFA	PDGFA	3713	0.15	0.58	YES
78	VCL	VCL	VCL	3750	0.15	0.58	YES
79	ITGA9	ITGA9	ITGA9	3837	0.14	0.58	YES
80	LAMB1	LAMB1	LAMB1	3874	0.14	0.58	YES
81	ACTN3	ACTN3	ACTN3	3908	0.14	0.58	YES
82	VAV1	VAV1	VAV1	3960	0.14	0.58	YES
83	BIRC2	BIRC2	BIRC2	4007	0.14	0.59	YES
84	RAP1A	RAP1A	RAP1A	4091	0.13	0.58	YES
85	SOS2	SOS2	SOS2	4099	0.13	0.59	YES
86	PPP1R12A	PPP1R12A	PPP1R12A	4186	0.13	0.59	YES
87	ITGB5	ITGB5	ITGB5	4254	0.12	0.59	YES
88	ARHGAP5	ARHGAP5	ARHGAP5	4265	0.12	0.59	YES
89	EGFR	EGFR	EGFR	4305	0.12	0.59	YES
90	PGF	PGF	PGF	4337	0.12	0.59	YES
91	ITGB1	ITGB1	ITGB1	4461	0.12	0.59	NO
92	TLN1	TLN1	TLN1	4562	0.11	0.59	NO
93	SOS1	SOS1	SOS1	4575	0.11	0.59	NO
94	DOCK1	DOCK1	DOCK1	4784	0.11	0.58	NO
95	ACTN1	ACTN1	ACTN1	4867	0.1	0.58	NO
96	ROCK2	ROCK2	ROCK2	4986	0.1	0.58	NO
97	BRAF	BRAF	BRAF	5099	0.098	0.57	NO
98	PARVA	PARVA	PARVA	5187	0.095	0.57	NO
99	RAPGEF1	RAPGEF1	RAPGEF1	5260	0.093	0.57	NO
100	LAMA1	LAMA1	LAMA1	5417	0.089	0.56	NO
101	IGF1R	IGF1R	IGF1R	5477	0.087	0.56	NO
102	LAMB4	LAMB4	LAMB4	5521	0.086	0.56	NO
103	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.56	NO
104	PIK3R3	PIK3R3	PIK3R3	5593	0.084	0.56	NO
105	ITGA8	ITGA8	ITGA8	5676	0.082	0.56	NO
106	PTEN	PTEN	PTEN	5692	0.082	0.56	NO
107	PPP1CB	PPP1CB	PPP1CB	5722	0.081	0.56	NO
108	SHC3	SHC3	SHC3	5969	0.075	0.55	NO
109	PAK2	PAK2	PAK2	6049	0.073	0.55	NO
110	LAMC2	LAMC2	LAMC2	6120	0.072	0.55	NO
111	VEGFB	VEGFB	VEGFB	6191	0.071	0.55	NO
112	MET	MET	MET	6251	0.069	0.54	NO
113	SHC2	SHC2	SHC2	6265	0.069	0.55	NO
114	LAMA3	LAMA3	LAMA3	6267	0.069	0.55	NO
115	CCND1	CCND1	CCND1	6399	0.066	0.54	NO
116	LAMA5	LAMA5	LAMA5	6616	0.061	0.53	NO
117	PIK3CB	PIK3CB	PIK3CB	6898	0.056	0.52	NO
118	VAV2	VAV2	VAV2	6981	0.055	0.52	NO
119	XIAP	XIAP	XIAP	7025	0.054	0.51	NO
120	CDC42	CDC42	CDC42	7140	0.052	0.51	NO
121	JUN	JUN	JUN	7148	0.052	0.51	NO
122	SHC1	SHC1	SHC1	7250	0.05	0.51	NO
123	PTK2	PTK2	PTK2	7335	0.048	0.5	NO
124	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.5	NO
125	PIP5K1C	PIP5K1C	PIP5K1C	7507	0.045	0.5	NO
126	MAPK1	MAPK1	MAPK1	7616	0.043	0.49	NO
127	ITGA2	ITGA2	ITGA2	7649	0.043	0.49	NO
128	ILK	ILK	ILK	7686	0.042	0.49	NO
129	MAPK9	MAPK9	MAPK9	7695	0.042	0.49	NO
130	RAC1	RAC1	RAC1	7768	0.04	0.49	NO
131	MYL2	MYL2	MYL2	7799	0.04	0.49	NO
132	CAPN2	CAPN2	CAPN2	7972	0.037	0.48	NO
133	ZYX	ZYX	ZYX	8040	0.036	0.48	NO
134	RHOA	RHOA	RHOA	8291	0.032	0.46	NO
135	GSK3B	GSK3B	GSK3B	8561	0.028	0.45	NO
136	MYL12A	MYL12A	MYL12A	8710	0.025	0.44	NO
137	VAV3	VAV3	VAV3	8800	0.023	0.44	NO
138	PAK1	PAK1	PAK1	8925	0.021	0.43	NO
139	CRKL	CRKL	CRKL	8977	0.02	0.43	NO
140	GRB2	GRB2	GRB2	8992	0.02	0.43	NO
141	TLN2	TLN2	TLN2	8995	0.02	0.43	NO
142	FLNB	FLNB	FLNB	9227	0.016	0.42	NO
143	LAMB3	LAMB3	LAMB3	9349	0.014	0.41	NO
144	CTNNB1	CTNNB1	CTNNB1	9483	0.012	0.4	NO
145	DIAPH1	DIAPH1	DIAPH1	9515	0.011	0.4	NO
146	CRK	CRK	CRK	9611	0.0098	0.4	NO
147	RAP1B	RAP1B	RAP1B	9615	0.0098	0.4	NO
148	MAPK8	MAPK8	MAPK8	9791	0.0065	0.39	NO
149	MYLK2	MYLK2	MYLK2	9819	0.006	0.38	NO
150	RAC2	RAC2	RAC2	9895	0.0047	0.38	NO
151	GRLF1	GRLF1	GRLF1	9916	0.0044	0.38	NO
152	ITGB6	ITGB6	ITGB6	9986	0.0034	0.38	NO
153	PXN	PXN	PXN	10057	0.0022	0.37	NO
154	RAF1	RAF1	RAF1	10109	0.0014	0.37	NO
155	ITGB7	ITGB7	ITGB7	10154	0.00058	0.37	NO
156	ELK1	ELK1	ELK1	10283	-0.0014	0.36	NO
157	VEGFA	VEGFA	VEGFA	10359	-0.0026	0.36	NO
158	ACTB	ACTB	ACTB	10373	-0.0029	0.36	NO
159	CCND2	CCND2	CCND2	10427	-0.0039	0.35	NO
160	PPP1CC	PPP1CC	PPP1CC	10433	-0.004	0.35	NO
161	ACTN4	ACTN4	ACTN4	10523	-0.0055	0.35	NO
162	PDPK1	PDPK1	PDPK1	10945	-0.013	0.32	NO
163	PRKCA	PRKCA	PRKCA	11032	-0.014	0.32	NO
164	ERBB2	ERBB2	ERBB2	11296	-0.019	0.3	NO
165	AKT1	AKT1	AKT1	11433	-0.022	0.3	NO
166	ITGA6	ITGA6	ITGA6	11479	-0.022	0.3	NO
167	VASP	VASP	VASP	11487	-0.022	0.3	NO
168	SRC	SRC	SRC	11558	-0.024	0.29	NO
169	PARVB	PARVB	PARVB	11707	-0.026	0.29	NO
170	LAMC3	LAMC3	LAMC3	11840	-0.029	0.28	NO
171	AKT2	AKT2	AKT2	11925	-0.03	0.28	NO
172	BCAR1	BCAR1	BCAR1	12352	-0.038	0.25	NO
173	MAPK3	MAPK3	MAPK3	12556	-0.042	0.24	NO
174	ITGB4	ITGB4	ITGB4	12772	-0.045	0.23	NO
175	ACTG1	ACTG1	ACTG1	12783	-0.046	0.23	NO
176	ITGA3	ITGA3	ITGA3	12822	-0.046	0.23	NO
177	MYL12B	MYL12B	MYL12B	12843	-0.047	0.23	NO
178	PAK4	PAK4	PAK4	13193	-0.054	0.21	NO
179	EGF	EGF	EGF	13212	-0.055	0.22	NO
180	CCND3	CCND3	CCND3	13498	-0.061	0.2	NO
181	PPP1CA	PPP1CA	PPP1CA	13639	-0.064	0.2	NO
182	PAK6	PAK6	PAK6	13717	-0.066	0.19	NO
183	PIK3R2	PIK3R2	PIK3R2	14099	-0.075	0.17	NO
184	RASGRF1	RASGRF1	RASGRF1	14244	-0.08	0.17	NO
185	CHAD	CHAD	CHAD	14397	-0.084	0.16	NO
186	BAD	BAD	BAD	14823	-0.097	0.14	NO
187	ITGA2B	ITGA2B	ITGA2B	14854	-0.098	0.14	NO
188	PRKCG	PRKCG	PRKCG	14986	-0.1	0.14	NO
189	COL11A2	COL11A2	COL11A2	15494	-0.12	0.11	NO
190	RAC3	RAC3	RAC3	15589	-0.13	0.11	NO
191	COL2A1	COL2A1	COL2A1	15801	-0.14	0.1	NO
192	MYL5	MYL5	MYL5	16032	-0.15	0.094	NO
193	MYLPF	MYLPF	MYLPF	17605	-0.35	0.016	NO
194	COL4A6	COL4A6	COL4A6	17689	-0.38	0.022	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FGF14	FGF14	FGF14	10	0.95	0.067	YES
2	FGF1	FGF1	FGF1	94	0.78	0.12	YES
3	FGF7	FGF7	FGF7	121	0.76	0.17	YES
4	MITF	MITF	MITF	152	0.73	0.22	YES
5	IGF1	IGF1	IGF1	186	0.71	0.27	YES
6	FGF2	FGF2	FGF2	303	0.65	0.31	YES
7	FGF10	FGF10	FGF10	355	0.62	0.35	YES
8	FGF5	FGF5	FGF5	436	0.59	0.39	YES
9	HGF	HGF	HGF	518	0.56	0.42	YES
10	AKT3	AKT3	AKT3	569	0.54	0.46	YES
11	PDGFC	PDGFC	PDGFC	628	0.52	0.49	YES
12	FGF12	FGF12	FGF12	1333	0.38	0.48	YES
13	FGF13	FGF13	FGF13	1398	0.36	0.5	YES
14	PIK3CG	PIK3CG	PIK3CG	1455	0.36	0.52	YES
15	FGFR1	FGFR1	FGFR1	1521	0.35	0.54	YES
16	PIK3R5	PIK3R5	PIK3R5	1567	0.34	0.56	YES
17	PDGFD	PDGFD	PDGFD	1801	0.31	0.57	YES
18	PDGFRB	PDGFRB	PDGFRB	1803	0.31	0.6	YES
19	FGF9	FGF9	FGF9	2018	0.29	0.6	YES
20	PIK3CD	PIK3CD	PIK3CD	2163	0.27	0.62	YES
21	PDGFRA	PDGFRA	PDGFRA	2405	0.24	0.62	YES
22	PDGFB	PDGFB	PDGFB	2787	0.21	0.61	NO
23	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.61	NO
24	PDGFA	PDGFA	PDGFA	3713	0.15	0.58	NO
25	FGF11	FGF11	FGF11	4005	0.14	0.58	NO
26	EGFR	EGFR	EGFR	4305	0.12	0.57	NO
27	CDK6	CDK6	CDK6	4511	0.12	0.57	NO
28	BRAF	BRAF	BRAF	5099	0.098	0.54	NO
29	RB1	RB1	RB1	5265	0.093	0.54	NO
30	IGF1R	IGF1R	IGF1R	5477	0.087	0.53	NO
31	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.53	NO
32	PIK3R3	PIK3R3	PIK3R3	5593	0.084	0.54	NO
33	FGF18	FGF18	FGF18	5657	0.082	0.54	NO
34	PTEN	PTEN	PTEN	5692	0.082	0.55	NO
35	MET	MET	MET	6251	0.069	0.52	NO
36	CCND1	CCND1	CCND1	6399	0.066	0.52	NO
37	KRAS	KRAS	KRAS	6580	0.062	0.51	NO
38	PIK3CB	PIK3CB	PIK3CB	6898	0.056	0.5	NO
39	NRAS	NRAS	NRAS	6951	0.056	0.5	NO
40	E2F3	E2F3	E2F3	7249	0.05	0.48	NO
41	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.48	NO
42	MAPK1	MAPK1	MAPK1	7616	0.043	0.47	NO
43	FGF19	FGF19	FGF19	7697	0.042	0.47	NO
44	MDM2	MDM2	MDM2	9399	0.013	0.38	NO
45	CDH1	CDH1	CDH1	9848	0.0056	0.35	NO
46	RAF1	RAF1	RAF1	10109	0.0014	0.34	NO
47	AKT1	AKT1	AKT1	11433	-0.022	0.26	NO
48	FGF23	FGF23	FGF23	11545	-0.024	0.26	NO
49	AKT2	AKT2	AKT2	11925	-0.03	0.24	NO
50	FGF3	FGF3	FGF3	12139	-0.034	0.23	NO
51	CDKN2A	CDKN2A	CDKN2A	12317	-0.037	0.22	NO
52	FGF20	FGF20	FGF20	12370	-0.038	0.22	NO
53	MAPK3	MAPK3	MAPK3	12556	-0.042	0.22	NO
54	EGF	EGF	EGF	13212	-0.055	0.18	NO
55	CDKN1A	CDKN1A	CDKN1A	13676	-0.065	0.16	NO
56	PIK3R2	PIK3R2	PIK3R2	14099	-0.075	0.14	NO
57	CDK4	CDK4	CDK4	14226	-0.079	0.14	NO
58	TP53	TP53	TP53	14292	-0.081	0.15	NO
59	BAD	BAD	BAD	14823	-0.097	0.12	NO
60	HRAS	HRAS	HRAS	14840	-0.097	0.13	NO
61	MAP2K2	MAP2K2	MAP2K2	15004	-0.1	0.13	NO
62	FGF17	FGF17	FGF17	15020	-0.1	0.13	NO
63	ARAF	ARAF	ARAF	15092	-0.11	0.14	NO
64	FGF21	FGF21	FGF21	15096	-0.11	0.14	NO
65	FGF8	FGF8	FGF8	15845	-0.14	0.11	NO
66	E2F2	E2F2	E2F2	16264	-0.16	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FGF14	FGF14	FGF14	10	0.95	0.02	YES
2	RUNX1T1	RUNX1T1	RUNX1T1	70	0.8	0.033	YES
3	FGF1	FGF1	FGF1	94	0.78	0.048	YES
4	FGF7	FGF7	FGF7	121	0.76	0.063	YES
5	MITF	MITF	MITF	152	0.73	0.076	YES
6	TGFB3	TGFB3	TGFB3	154	0.73	0.092	YES
7	GLI3	GLI3	GLI3	162	0.73	0.11	YES
8	IGF1	IGF1	IGF1	186	0.71	0.12	YES
9	CCNA1	CCNA1	CCNA1	300	0.65	0.13	YES
10	FGF2	FGF2	FGF2	303	0.65	0.14	YES
11	AR	AR	AR	329	0.64	0.15	YES
12	FGF10	FGF10	FGF10	355	0.62	0.16	YES
13	FGF5	FGF5	FGF5	436	0.59	0.17	YES
14	VEGFC	VEGFC	VEGFC	474	0.57	0.18	YES
15	HGF	HGF	HGF	518	0.56	0.19	YES
16	GLI1	GLI1	GLI1	524	0.56	0.2	YES
17	RARB	RARB	RARB	533	0.55	0.21	YES
18	AKT3	AKT3	AKT3	569	0.54	0.22	YES
19	GLI2	GLI2	GLI2	597	0.53	0.23	YES
20	MAPK10	MAPK10	MAPK10	600	0.53	0.24	YES
21	TGFB2	TGFB2	TGFB2	639	0.52	0.25	YES
22	LAMA2	LAMA2	LAMA2	748	0.49	0.26	YES
23	ZBTB16	ZBTB16	ZBTB16	857	0.47	0.26	YES
24	HHIP	HHIP	HHIP	935	0.45	0.27	YES
25	WNT2	WNT2	WNT2	973	0.44	0.27	YES
26	CTNNA3	CTNNA3	CTNNA3	1048	0.43	0.28	YES
27	PRKCB	PRKCB	PRKCB	1108	0.41	0.28	YES
28	FGF12	FGF12	FGF12	1333	0.38	0.28	YES
29	PTCH2	PTCH2	PTCH2	1354	0.37	0.29	YES
30	COL4A4	COL4A4	COL4A4	1383	0.37	0.29	YES
31	FGF13	FGF13	FGF13	1398	0.36	0.3	YES
32	PIK3CG	PIK3CG	PIK3CG	1455	0.36	0.3	YES
33	FN1	FN1	FN1	1486	0.35	0.31	YES
34	FGFR1	FGFR1	FGFR1	1521	0.35	0.31	YES
35	PIK3R5	PIK3R5	PIK3R5	1567	0.34	0.32	YES
36	WNT9A	WNT9A	WNT9A	1598	0.34	0.32	YES
37	ARNT2	ARNT2	ARNT2	1651	0.33	0.33	YES
38	MMP9	MMP9	MMP9	1673	0.33	0.33	YES
39	FIGF	FIGF	FIGF	1751	0.32	0.34	YES
40	CDKN2B	CDKN2B	CDKN2B	1756	0.32	0.34	YES
41	MMP2	MMP2	MMP2	1776	0.31	0.35	YES
42	FZD8	FZD8	FZD8	1791	0.31	0.35	YES
43	PDGFRB	PDGFRB	PDGFRB	1803	0.31	0.36	YES
44	FZD4	FZD4	FZD4	1810	0.31	0.37	YES
45	CSF1R	CSF1R	CSF1R	1817	0.31	0.37	YES
46	WNT9B	WNT9B	WNT9B	1958	0.3	0.37	YES
47	IL6	IL6	IL6	1965	0.3	0.38	YES
48	FGF9	FGF9	FGF9	2018	0.29	0.38	YES
49	RET	RET	RET	2068	0.28	0.38	YES
50	LEF1	LEF1	LEF1	2100	0.28	0.39	YES
51	LAMA4	LAMA4	LAMA4	2118	0.28	0.39	YES
52	SPI1	SPI1	SPI1	2139	0.27	0.4	YES
53	PIK3CD	PIK3CD	PIK3CD	2163	0.27	0.4	YES
54	ITGAV	ITGAV	ITGAV	2189	0.27	0.4	YES
55	FGFR2	FGFR2	FGFR2	2196	0.27	0.41	YES
56	FZD1	FZD1	FZD1	2219	0.26	0.42	YES
57	NTRK1	NTRK1	NTRK1	2282	0.26	0.42	YES
58	ETS1	ETS1	ETS1	2290	0.26	0.42	YES
59	DAPK1	DAPK1	DAPK1	2381	0.25	0.42	YES
60	PDGFRA	PDGFRA	PDGFRA	2405	0.24	0.42	YES
61	FZD7	FZD7	FZD7	2406	0.24	0.43	YES
62	NKX3-1	NKX3-1	NKX3-1	2459	0.24	0.43	YES
63	TCF7L1	TCF7L1	TCF7L1	2487	0.24	0.44	YES
64	KIT	KIT	KIT	2561	0.23	0.44	YES
65	CSF2RA	CSF2RA	CSF2RA	2626	0.22	0.44	YES
66	FLT3	FLT3	FLT3	2647	0.22	0.44	YES
67	BCL2	BCL2	BCL2	2698	0.22	0.44	YES
68	PLCG2	PLCG2	PLCG2	2713	0.22	0.45	YES
69	WNT7A	WNT7A	WNT7A	2740	0.21	0.45	YES
70	CSF3R	CSF3R	CSF3R	2749	0.21	0.45	YES
71	FASLG	FASLG	FASLG	2772	0.21	0.46	YES
72	PDGFB	PDGFB	PDGFB	2787	0.21	0.46	YES
73	SMO	SMO	SMO	2790	0.21	0.46	YES
74	PTGS2	PTGS2	PTGS2	2795	0.21	0.47	YES
75	TRAF1	TRAF1	TRAF1	2868	0.2	0.47	YES
76	BIRC3	BIRC3	BIRC3	2903	0.2	0.47	YES
77	COL4A1	COL4A1	COL4A1	2988	0.19	0.47	YES
78	COL4A2	COL4A2	COL4A2	2998	0.19	0.48	YES
79	LAMB2	LAMB2	LAMB2	3057	0.19	0.48	YES
80	TGFBR1	TGFBR1	TGFBR1	3089	0.19	0.48	YES
81	RASSF5	RASSF5	RASSF5	3114	0.18	0.48	YES
82	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.48	YES
83	FOXO1	FOXO1	FOXO1	3236	0.18	0.48	YES
84	LAMC1	LAMC1	LAMC1	3385	0.16	0.48	YES
85	APC	APC	APC	3508	0.16	0.47	YES
86	TGFB1	TGFB1	TGFB1	3530	0.16	0.48	YES
87	STAT1	STAT1	STAT1	3550	0.16	0.48	YES
88	PDGFA	PDGFA	PDGFA	3713	0.15	0.47	YES
89	WNT5A	WNT5A	WNT5A	3724	0.15	0.47	YES
90	RUNX1	RUNX1	RUNX1	3796	0.14	0.47	YES
91	FOS	FOS	FOS	3800	0.14	0.48	YES
92	KITLG	KITLG	KITLG	3827	0.14	0.48	YES
93	WNT7B	WNT7B	WNT7B	3848	0.14	0.48	YES
94	LAMB1	LAMB1	LAMB1	3874	0.14	0.48	YES
95	WNT2B	WNT2B	WNT2B	3875	0.14	0.48	YES
96	APPL1	APPL1	APPL1	3942	0.14	0.48	YES
97	FGF11	FGF11	FGF11	4005	0.14	0.48	YES
98	BIRC2	BIRC2	BIRC2	4007	0.14	0.48	YES
99	FLT3LG	FLT3LG	FLT3LG	4047	0.13	0.48	YES
100	SOS2	SOS2	SOS2	4099	0.13	0.48	YES
101	WNT10B	WNT10B	WNT10B	4207	0.13	0.48	YES
102	HIF1A	HIF1A	HIF1A	4208	0.13	0.48	YES
103	TGFBR2	TGFBR2	TGFBR2	4234	0.13	0.49	YES
104	EGFR	EGFR	EGFR	4305	0.12	0.48	NO
105	PGF	PGF	PGF	4337	0.12	0.48	NO
106	ITGB1	ITGB1	ITGB1	4461	0.12	0.48	NO
107	CDK6	CDK6	CDK6	4511	0.12	0.48	NO
108	SOS1	SOS1	SOS1	4575	0.11	0.48	NO
109	FAS	FAS	FAS	4690	0.11	0.48	NO
110	CBL	CBL	CBL	4691	0.11	0.48	NO
111	FZD2	FZD2	FZD2	4731	0.11	0.48	NO
112	IL8	IL8	IL8	4950	0.1	0.47	NO
113	DCC	DCC	DCC	5040	0.1	0.46	NO
114	BRAF	BRAF	BRAF	5099	0.098	0.46	NO
115	CBLB	CBLB	CBLB	5162	0.096	0.46	NO
116	RB1	RB1	RB1	5265	0.093	0.46	NO
117	PTCH1	PTCH1	PTCH1	5412	0.089	0.45	NO
118	LAMA1	LAMA1	LAMA1	5417	0.089	0.45	NO
119	WNT11	WNT11	WNT11	5467	0.088	0.45	NO
120	IGF1R	IGF1R	IGF1R	5477	0.087	0.45	NO
121	CCNE2	CCNE2	CCNE2	5506	0.087	0.45	NO
122	LAMB4	LAMB4	LAMB4	5521	0.086	0.46	NO
123	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.45	NO
124	PIK3R3	PIK3R3	PIK3R3	5593	0.084	0.46	NO
125	JAK1	JAK1	JAK1	5625	0.083	0.46	NO
126	BMP2	BMP2	BMP2	5641	0.083	0.46	NO
127	FGF18	FGF18	FGF18	5657	0.082	0.46	NO
128	PTEN	PTEN	PTEN	5692	0.082	0.46	NO
129	RALA	RALA	RALA	5744	0.08	0.46	NO
130	CTNNA2	CTNNA2	CTNNA2	5798	0.079	0.45	NO
131	ARNT	ARNT	ARNT	5860	0.078	0.45	NO
132	BRCA2	BRCA2	BRCA2	6021	0.074	0.44	NO
133	EP300	EP300	EP300	6024	0.074	0.45	NO
134	PIAS3	PIAS3	PIAS3	6044	0.074	0.45	NO
135	TRAF5	TRAF5	TRAF5	6061	0.073	0.45	NO
136	LAMC2	LAMC2	LAMC2	6120	0.072	0.44	NO
137	PLD1	PLD1	PLD1	6146	0.072	0.44	NO
138	FZD6	FZD6	FZD6	6165	0.071	0.45	NO
139	VEGFB	VEGFB	VEGFB	6191	0.071	0.45	NO
140	SMAD2	SMAD2	SMAD2	6193	0.071	0.45	NO
141	NFKB2	NFKB2	NFKB2	6195	0.07	0.45	NO
142	CASP8	CASP8	CASP8	6206	0.07	0.45	NO
143	MET	MET	MET	6251	0.069	0.45	NO
144	LAMA3	LAMA3	LAMA3	6267	0.069	0.45	NO
145	STK4	STK4	STK4	6268	0.069	0.45	NO
146	TPR	TPR	TPR	6358	0.067	0.45	NO
147	RALB	RALB	RALB	6368	0.066	0.45	NO
148	CCND1	CCND1	CCND1	6399	0.066	0.45	NO
149	PIAS2	PIAS2	PIAS2	6513	0.064	0.44	NO
150	EPAS1	EPAS1	EPAS1	6525	0.063	0.44	NO
151	KRAS	KRAS	KRAS	6580	0.062	0.44	NO
152	LAMA5	LAMA5	LAMA5	6616	0.061	0.44	NO
153	SMAD4	SMAD4	SMAD4	6621	0.061	0.44	NO
154	STAT5B	STAT5B	STAT5B	6690	0.06	0.44	NO
155	MAX	MAX	MAX	6706	0.06	0.44	NO
156	ABL1	ABL1	ABL1	6764	0.059	0.44	NO
157	MMP1	MMP1	MMP1	6858	0.057	0.43	NO
158	PIK3CB	PIK3CB	PIK3CB	6898	0.056	0.43	NO
159	NRAS	NRAS	NRAS	6951	0.056	0.43	NO
160	CDKN1B	CDKN1B	CDKN1B	6979	0.055	0.43	NO
161	HSP90B1	HSP90B1	HSP90B1	7002	0.054	0.43	NO
162	XIAP	XIAP	XIAP	7025	0.054	0.43	NO
163	SUFU	SUFU	SUFU	7031	0.054	0.43	NO
164	WNT1	WNT1	WNT1	7036	0.054	0.43	NO
165	TGFA	TGFA	TGFA	7076	0.053	0.43	NO
166	CDC42	CDC42	CDC42	7140	0.052	0.43	NO
167	JUN	JUN	JUN	7148	0.052	0.43	NO
168	NFKBIA	NFKBIA	NFKBIA	7197	0.051	0.43	NO
169	E2F3	E2F3	E2F3	7249	0.05	0.43	NO
170	RARA	RARA	RARA	7288	0.049	0.42	NO
171	PTK2	PTK2	PTK2	7335	0.048	0.42	NO
172	NCOA4	NCOA4	NCOA4	7375	0.047	0.42	NO
173	MLH1	MLH1	MLH1	7429	0.046	0.42	NO
174	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.42	NO
175	TRAF6	TRAF6	TRAF6	7577	0.044	0.41	NO
176	HSP90AA1	HSP90AA1	HSP90AA1	7581	0.044	0.42	NO
177	MAPK1	MAPK1	MAPK1	7616	0.043	0.41	NO
178	ITGA2	ITGA2	ITGA2	7649	0.043	0.41	NO
179	CREBBP	CREBBP	CREBBP	7651	0.042	0.41	NO
180	MSH2	MSH2	MSH2	7653	0.042	0.41	NO
181	SMAD3	SMAD3	SMAD3	7666	0.042	0.42	NO
182	MAPK9	MAPK9	MAPK9	7695	0.042	0.41	NO
183	FGF19	FGF19	FGF19	7697	0.042	0.42	NO
184	RAC1	RAC1	RAC1	7768	0.04	0.41	NO
185	HDAC2	HDAC2	HDAC2	7828	0.039	0.41	NO
186	BMP4	BMP4	BMP4	7840	0.039	0.41	NO
187	STAT5A	STAT5A	STAT5A	7954	0.038	0.4	NO
188	CYCS	CYCS	CYCS	8045	0.036	0.4	NO
189	CUL2	CUL2	CUL2	8058	0.036	0.4	NO
190	RXRG	RXRG	RXRG	8102	0.035	0.4	NO
191	IKBKB	IKBKB	IKBKB	8179	0.034	0.39	NO
192	RHOA	RHOA	RHOA	8291	0.032	0.39	NO
193	PIAS1	PIAS1	PIAS1	8304	0.032	0.39	NO
194	MSH3	MSH3	MSH3	8307	0.032	0.39	NO
195	STAT3	STAT3	STAT3	8346	0.031	0.39	NO
196	PLCG1	PLCG1	PLCG1	8386	0.03	0.39	NO
197	NFKB1	NFKB1	NFKB1	8473	0.029	0.38	NO
198	CCDC6	CCDC6	CCDC6	8517	0.028	0.38	NO
199	GSK3B	GSK3B	GSK3B	8561	0.028	0.38	NO
200	TRAF2	TRAF2	TRAF2	8564	0.028	0.38	NO
201	CHUK	CHUK	CHUK	8569	0.028	0.38	NO
202	RALGDS	RALGDS	RALGDS	8597	0.027	0.38	NO
203	RXRA	RXRA	RXRA	8638	0.026	0.38	NO
204	WNT16	WNT16	WNT16	8724	0.025	0.37	NO
205	TCF7	TCF7	TCF7	8941	0.021	0.36	NO
206	EGLN1	EGLN1	EGLN1	8950	0.02	0.36	NO
207	CRKL	CRKL	CRKL	8977	0.02	0.36	NO
208	GRB2	GRB2	GRB2	8992	0.02	0.36	NO
209	TCEB1	TCEB1	TCEB1	9125	0.018	0.35	NO
210	PML	PML	PML	9130	0.018	0.35	NO
211	KLK3	KLK3	KLK3	9145	0.017	0.35	NO
212	HSP90AB1	HSP90AB1	HSP90AB1	9209	0.016	0.35	NO
213	RELA	RELA	RELA	9233	0.016	0.35	NO
214	MSH6	MSH6	MSH6	9268	0.015	0.35	NO
215	LAMB3	LAMB3	LAMB3	9349	0.014	0.34	NO
216	MDM2	MDM2	MDM2	9399	0.013	0.34	NO
217	CTNNB1	CTNNB1	CTNNB1	9483	0.012	0.34	NO
218	FZD10	FZD10	FZD10	9525	0.011	0.33	NO
219	TRAF3	TRAF3	TRAF3	9552	0.011	0.33	NO
220	CRK	CRK	CRK	9611	0.0098	0.33	NO
221	TPM3	TPM3	TPM3	9692	0.0082	0.32	NO
222	MAPK8	MAPK8	MAPK8	9791	0.0065	0.32	NO
223	MTOR	MTOR	MTOR	9823	0.006	0.32	NO
224	CDH1	CDH1	CDH1	9848	0.0056	0.32	NO
225	RAC2	RAC2	RAC2	9895	0.0047	0.31	NO
226	CTNNA1	CTNNA1	CTNNA1	9956	0.0038	0.31	NO
227	WNT10A	WNT10A	WNT10A	9964	0.0037	0.31	NO
228	BCL2L1	BCL2L1	BCL2L1	10017	0.003	0.31	NO
229	RAF1	RAF1	RAF1	10109	0.0014	0.3	NO
230	RBX1	RBX1	RBX1	10187	-1.1e-06	0.3	NO
231	CASP3	CASP3	CASP3	10199	-0.0002	0.3	NO
232	DVL3	DVL3	DVL3	10315	-0.002	0.29	NO
233	VEGFA	VEGFA	VEGFA	10359	-0.0026	0.29	NO
234	TCF7L2	TCF7L2	TCF7L2	10507	-0.0054	0.28	NO
235	PPARD	PPARD	PPARD	10607	-0.0069	0.28	NO
236	RALBP1	RALBP1	RALBP1	10611	-0.007	0.27	NO
237	WNT3A	WNT3A	WNT3A	10653	-0.0078	0.27	NO
238	VHL	VHL	VHL	10904	-0.012	0.26	NO
239	DVL2	DVL2	DVL2	10956	-0.013	0.26	NO
240	PRKCA	PRKCA	PRKCA	11032	-0.014	0.25	NO
241	EGLN2	EGLN2	EGLN2	11044	-0.014	0.25	NO
242	RXRB	RXRB	RXRB	11080	-0.015	0.25	NO
243	MECOM	MECOM	MECOM	11100	-0.016	0.25	NO
244	DAPK3	DAPK3	DAPK3	11230	-0.018	0.24	NO
245	WNT3	WNT3	WNT3	11279	-0.019	0.24	NO
246	ERBB2	ERBB2	ERBB2	11296	-0.019	0.24	NO
247	AKT1	AKT1	AKT1	11433	-0.022	0.23	NO
248	WNT5B	WNT5B	WNT5B	11435	-0.022	0.23	NO
249	ITGA6	ITGA6	ITGA6	11479	-0.022	0.23	NO
250	FGF23	FGF23	FGF23	11545	-0.024	0.23	NO
251	CDK2	CDK2	CDK2	11547	-0.024	0.23	NO
252	CASP9	CASP9	CASP9	11613	-0.025	0.22	NO
253	HDAC1	HDAC1	HDAC1	11617	-0.025	0.22	NO
254	DAPK2	DAPK2	DAPK2	11744	-0.027	0.22	NO
255	LAMC3	LAMC3	LAMC3	11840	-0.029	0.21	NO
256	AKT2	AKT2	AKT2	11925	-0.03	0.21	NO
257	FADD	FADD	FADD	12012	-0.032	0.21	NO
258	AXIN1	AXIN1	AXIN1	12051	-0.032	0.2	NO
259	EGLN3	EGLN3	EGLN3	12058	-0.033	0.2	NO
260	FGF3	FGF3	FGF3	12139	-0.034	0.2	NO
261	STK36	STK36	STK36	12235	-0.035	0.2	NO
262	TFG	TFG	TFG	12264	-0.036	0.2	NO
263	CDKN2A	CDKN2A	CDKN2A	12317	-0.037	0.19	NO
264	IKBKG	IKBKG	IKBKG	12339	-0.038	0.19	NO
265	PPARG	PPARG	PPARG	12360	-0.038	0.19	NO
266	FGF20	FGF20	FGF20	12370	-0.038	0.19	NO
267	RASSF1	RASSF1	RASSF1	12402	-0.039	0.19	NO
268	MAPK3	MAPK3	MAPK3	12556	-0.042	0.18	NO
269	CTBP2	CTBP2	CTBP2	12627	-0.043	0.18	NO
270	ITGA3	ITGA3	ITGA3	12822	-0.046	0.17	NO
271	RAD51	RAD51	RAD51	12904	-0.048	0.17	NO
272	CTBP1	CTBP1	CTBP1	13085	-0.052	0.16	NO
273	FZD5	FZD5	FZD5	13156	-0.054	0.16	NO
274	EGF	EGF	EGF	13212	-0.055	0.15	NO
275	JUP	JUP	JUP	13228	-0.055	0.15	NO
276	BCR	BCR	BCR	13319	-0.058	0.15	NO
277	CDKN1A	CDKN1A	CDKN1A	13676	-0.065	0.13	NO
278	SLC2A1	SLC2A1	SLC2A1	13992	-0.072	0.12	NO
279	MYC	MYC	MYC	14032	-0.074	0.12	NO
280	SKP2	SKP2	SKP2	14040	-0.074	0.12	NO
281	PIK3R2	PIK3R2	PIK3R2	14099	-0.075	0.11	NO
282	CEBPA	CEBPA	CEBPA	14215	-0.078	0.11	NO
283	CDK4	CDK4	CDK4	14226	-0.079	0.11	NO
284	BAX	BAX	BAX	14227	-0.079	0.11	NO
285	TP53	TP53	TP53	14292	-0.081	0.11	NO
286	FH	FH	FH	14363	-0.083	0.11	NO
287	DVL1	DVL1	DVL1	14623	-0.091	0.096	NO
288	E2F1	E2F1	E2F1	14631	-0.091	0.097	NO
289	BIRC5	BIRC5	BIRC5	14637	-0.091	0.099	NO
290	BAD	BAD	BAD	14823	-0.097	0.09	NO
291	PAX8	PAX8	PAX8	14829	-0.097	0.092	NO
292	ITGA2B	ITGA2B	ITGA2B	14854	-0.098	0.093	NO
293	PIAS4	PIAS4	PIAS4	14894	-0.099	0.093	NO
294	PRKCG	PRKCG	PRKCG	14986	-0.1	0.09	NO
295	MAP2K2	MAP2K2	MAP2K2	15004	-0.1	0.091	NO
296	FGF17	FGF17	FGF17	15020	-0.1	0.092	NO
297	TCEB2	TCEB2	TCEB2	15043	-0.1	0.093	NO
298	ARAF	ARAF	ARAF	15092	-0.11	0.093	NO
299	FGF21	FGF21	FGF21	15096	-0.11	0.095	NO
300	BID	BID	BID	15200	-0.11	0.091	NO
301	WNT6	WNT6	WNT6	15250	-0.11	0.091	NO
302	CKS1B	CKS1B	CKS1B	15313	-0.11	0.09	NO
303	AXIN2	AXIN2	AXIN2	15531	-0.12	0.08	NO
304	GSTP1	GSTP1	GSTP1	15532	-0.12	0.083	NO
305	CCNE1	CCNE1	CCNE1	15585	-0.12	0.082	NO
306	RAC3	RAC3	RAC3	15589	-0.13	0.085	NO
307	WNT8B	WNT8B	WNT8B	15601	-0.13	0.087	NO
308	TRAF4	TRAF4	TRAF4	15676	-0.13	0.085	NO
309	FGF8	FGF8	FGF8	15845	-0.14	0.079	NO
310	CBLC	CBLC	CBLC	16234	-0.16	0.06	NO
311	E2F2	E2F2	E2F2	16264	-0.16	0.062	NO
312	FZD3	FZD3	FZD3	16364	-0.17	0.06	NO
313	NOS2	NOS2	NOS2	16459	-0.18	0.058	NO
314	SHH	SHH	SHH	16560	-0.18	0.057	NO
315	FGFR3	FGFR3	FGFR3	17012	-0.23	0.036	NO
316	FZD9	FZD9	FZD9	17105	-0.24	0.036	NO
317	WNT4	WNT4	WNT4	17237	-0.27	0.034	NO
318	APC2	APC2	APC2	17250	-0.27	0.039	NO
319	COL4A6	COL4A6	COL4A6	17689	-0.38	0.023	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AKT3	AKT3	AKT3	569	0.54	0.041	YES
2	MAPK10	MAPK10	MAPK10	600	0.53	0.11	YES
3	ADIPOQ	ADIPOQ	ADIPOQ	611	0.53	0.18	YES
4	CD36	CD36	CD36	634	0.52	0.25	YES
5	LEP	LEP	LEP	1015	0.43	0.28	YES
6	CPT1C	CPT1C	CPT1C	1243	0.39	0.32	YES
7	SLC2A4	SLC2A4	SLC2A4	1804	0.31	0.34	YES
8	LEPR	LEPR	LEPR	1816	0.31	0.38	YES
9	POMC	POMC	POMC	1978	0.29	0.41	YES
10	NPY	NPY	NPY	2152	0.27	0.43	YES
11	JAK2	JAK2	JAK2	2293	0.26	0.46	YES
12	PRKAA2	PRKAA2	PRKAA2	2566	0.23	0.47	YES
13	TNF	TNF	TNF	3135	0.18	0.47	YES
14	IRS1	IRS1	IRS1	3158	0.18	0.49	YES
15	SOCS3	SOCS3	SOCS3	3286	0.17	0.51	YES
16	PRKAB2	PRKAB2	PRKAB2	4039	0.13	0.48	NO
17	AGRP	AGRP	AGRP	4438	0.12	0.48	NO
18	PCK1	PCK1	PCK1	4666	0.11	0.48	NO
19	PRKAA1	PRKAA1	PRKAA1	4685	0.11	0.49	NO
20	ACSL4	ACSL4	ACSL4	5067	0.099	0.48	NO
21	ACSL1	ACSL1	ACSL1	5820	0.078	0.45	NO
22	ACSL3	ACSL3	ACSL3	6684	0.06	0.41	NO
23	PTPN11	PTPN11	PTPN11	6751	0.059	0.42	NO
24	PRKAG2	PRKAG2	PRKAG2	6938	0.056	0.41	NO
25	G6PC2	G6PC2	G6PC2	6996	0.055	0.42	NO
26	ACSL6	ACSL6	ACSL6	7043	0.054	0.42	NO
27	NFKBIA	NFKBIA	NFKBIA	7197	0.051	0.42	NO
28	PPARA	PPARA	PPARA	7564	0.044	0.41	NO
29	MAPK9	MAPK9	MAPK9	7695	0.042	0.4	NO
30	IRS2	IRS2	IRS2	7772	0.04	0.41	NO
31	RXRG	RXRG	RXRG	8102	0.035	0.39	NO
32	IKBKB	IKBKB	IKBKB	8179	0.034	0.39	NO
33	STAT3	STAT3	STAT3	8346	0.031	0.39	NO
34	NFKB1	NFKB1	NFKB1	8473	0.029	0.38	NO
35	TRAF2	TRAF2	TRAF2	8564	0.028	0.38	NO
36	CHUK	CHUK	CHUK	8569	0.028	0.39	NO
37	RXRA	RXRA	RXRA	8638	0.026	0.39	NO
38	ACACB	ACACB	ACACB	8952	0.02	0.37	NO
39	CAMKK2	CAMKK2	CAMKK2	8984	0.02	0.37	NO
40	RELA	RELA	RELA	9233	0.016	0.36	NO
41	NFKBIE	NFKBIE	NFKBIE	9407	0.013	0.35	NO
42	TNFRSF1B	TNFRSF1B	TNFRSF1B	9479	0.012	0.35	NO
43	MAPK8	MAPK8	MAPK8	9791	0.0065	0.33	NO
44	MTOR	MTOR	MTOR	9823	0.006	0.33	NO
45	ACSL5	ACSL5	ACSL5	10071	0.0021	0.32	NO
46	ADIPOR1	ADIPOR1	ADIPOR1	10341	-0.0023	0.3	NO
47	ADIPOR2	ADIPOR2	ADIPOR2	10380	-0.0031	0.3	NO
48	PPARGC1A	PPARGC1A	PPARGC1A	10525	-0.0056	0.3	NO
49	RXRB	RXRB	RXRB	11080	-0.015	0.27	NO
50	G6PC	G6PC	G6PC	11084	-0.015	0.27	NO
51	CAMKK1	CAMKK1	CAMKK1	11112	-0.016	0.27	NO
52	AKT1	AKT1	AKT1	11433	-0.022	0.26	NO
53	TNFRSF1A	TNFRSF1A	TNFRSF1A	11562	-0.024	0.25	NO
54	CPT1A	CPT1A	CPT1A	11663	-0.026	0.25	NO
55	PRKAG1	PRKAG1	PRKAG1	11769	-0.028	0.25	NO
56	AKT2	AKT2	AKT2	11925	-0.03	0.24	NO
57	IKBKG	IKBKG	IKBKG	12339	-0.038	0.22	NO
58	PRKCQ	PRKCQ	PRKCQ	12351	-0.038	0.23	NO
59	NFKBIB	NFKBIB	NFKBIB	13180	-0.054	0.19	NO
60	PRKAB1	PRKAB1	PRKAB1	13925	-0.07	0.16	NO
61	SLC2A1	SLC2A1	SLC2A1	13992	-0.072	0.16	NO
62	PCK2	PCK2	PCK2	14175	-0.077	0.16	NO
63	TRADD	TRADD	TRADD	14218	-0.079	0.17	NO
64	STK11	STK11	STK11	15640	-0.13	0.11	NO
65	CPT1B	CPT1B	CPT1B	16606	-0.19	0.082	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CACNA2D1	CACNA2D1	CACNA2D1	80	0.79	0.051	YES
2	CDH2	CDH2	CDH2	118	0.76	0.1	YES
3	SGCD	SGCD	SGCD	202	0.7	0.15	YES
4	DES	DES	DES	364	0.62	0.18	YES
5	ITGA10	ITGA10	ITGA10	664	0.51	0.2	YES
6	SGCG	SGCG	SGCG	695	0.5	0.23	YES
7	LAMA2	LAMA2	LAMA2	748	0.49	0.26	YES
8	ITGA11	ITGA11	ITGA11	849	0.47	0.29	YES
9	ACTN2	ACTN2	ACTN2	892	0.46	0.32	YES
10	SGCA	SGCA	SGCA	895	0.46	0.35	YES
11	CACNB4	CACNB4	CACNB4	937	0.45	0.38	YES
12	SLC8A1	SLC8A1	SLC8A1	967	0.44	0.41	YES
13	CTNNA3	CTNNA3	CTNNA3	1048	0.43	0.44	YES
14	ITGA4	ITGA4	ITGA4	1438	0.36	0.44	YES
15	ITGB3	ITGB3	ITGB3	1559	0.34	0.46	YES
16	ITGA7	ITGA7	ITGA7	1743	0.32	0.47	YES
17	RYR2	RYR2	RYR2	1774	0.32	0.49	YES
18	GJA1	GJA1	GJA1	1882	0.3	0.51	YES
19	ITGA5	ITGA5	ITGA5	1904	0.3	0.53	YES
20	DMD	DMD	DMD	1947	0.3	0.55	YES
21	LEF1	LEF1	LEF1	2100	0.28	0.56	YES
22	ITGAV	ITGAV	ITGAV	2189	0.27	0.57	YES
23	ITGB8	ITGB8	ITGB8	2197	0.27	0.59	YES
24	ITGA1	ITGA1	ITGA1	2201	0.27	0.61	YES
25	CACNB2	CACNB2	CACNB2	2434	0.24	0.61	YES
26	TCF7L1	TCF7L1	TCF7L1	2487	0.24	0.62	YES
27	CACNA1C	CACNA1C	CACNA1C	2697	0.22	0.63	YES
28	CACNG4	CACNG4	CACNG4	2885	0.2	0.63	YES
29	SGCB	SGCB	SGCB	3501	0.16	0.61	NO
30	ITGA9	ITGA9	ITGA9	3837	0.14	0.6	NO
31	ACTN3	ACTN3	ACTN3	3908	0.14	0.61	NO
32	ITGB5	ITGB5	ITGB5	4254	0.12	0.6	NO
33	ITGB1	ITGB1	ITGB1	4461	0.12	0.59	NO
34	ACTN1	ACTN1	ACTN1	4867	0.1	0.58	NO
35	ITGA8	ITGA8	ITGA8	5676	0.082	0.54	NO
36	CACNG6	CACNG6	CACNG6	5680	0.082	0.54	NO
37	CTNNA2	CTNNA2	CTNNA2	5798	0.079	0.54	NO
38	CACNA2D4	CACNA2D4	CACNA2D4	6284	0.068	0.52	NO
39	CACNG1	CACNG1	CACNG1	6683	0.06	0.5	NO
40	DSP	DSP	DSP	7469	0.046	0.46	NO
41	CACNB1	CACNB1	CACNB1	7493	0.045	0.46	NO
42	CACNA2D3	CACNA2D3	CACNA2D3	7621	0.043	0.46	NO
43	ITGA2	ITGA2	ITGA2	7649	0.043	0.46	NO
44	LMNA	LMNA	LMNA	8269	0.032	0.43	NO
45	DSC2	DSC2	DSC2	8322	0.031	0.43	NO
46	TCF7	TCF7	TCF7	8941	0.021	0.4	NO
47	CACNB3	CACNB3	CACNB3	9063	0.019	0.39	NO
48	DAG1	DAG1	DAG1	9193	0.017	0.38	NO
49	CTNNB1	CTNNB1	CTNNB1	9483	0.012	0.37	NO
50	CTNNA1	CTNNA1	CTNNA1	9956	0.0038	0.34	NO
51	ITGB6	ITGB6	ITGB6	9986	0.0034	0.34	NO
52	ITGB7	ITGB7	ITGB7	10154	0.00058	0.33	NO
53	ATP2A2	ATP2A2	ATP2A2	10161	0.00038	0.33	NO
54	DSG2	DSG2	DSG2	10279	-0.0013	0.33	NO
55	ACTB	ACTB	ACTB	10373	-0.0029	0.32	NO
56	TCF7L2	TCF7L2	TCF7L2	10507	-0.0054	0.31	NO
57	ACTN4	ACTN4	ACTN4	10523	-0.0055	0.31	NO
58	ITGA6	ITGA6	ITGA6	11479	-0.022	0.26	NO
59	CACNA1D	CACNA1D	CACNA1D	12269	-0.036	0.22	NO
60	ITGB4	ITGB4	ITGB4	12772	-0.045	0.2	NO
61	ACTG1	ACTG1	ACTG1	12783	-0.046	0.2	NO
62	ITGA3	ITGA3	ITGA3	12822	-0.046	0.2	NO
63	JUP	JUP	JUP	13228	-0.055	0.18	NO
64	EMD	EMD	EMD	13292	-0.057	0.18	NO
65	PKP2	PKP2	PKP2	13731	-0.066	0.16	NO
66	ITGA2B	ITGA2B	ITGA2B	14854	-0.098	0.11	NO
67	CACNA2D2	CACNA2D2	CACNA2D2	16640	-0.19	0.021	NO
68	CACNG8	CACNG8	CACNG8	17214	-0.26	0.0076	NO
69	CACNA1S	CACNA1S	CACNA1S	17301	-0.28	0.022	NO
70	CACNA1F	CACNA1F	CACNA1F	17447	-0.31	0.036	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RUNX1T1	RUNX1T1	RUNX1T1	70	0.8	0.1	YES
2	CCNA1	CCNA1	CCNA1	300	0.65	0.17	YES
3	AKT3	AKT3	AKT3	569	0.54	0.23	YES
4	ZBTB16	ZBTB16	ZBTB16	857	0.47	0.28	YES
5	PIK3CG	PIK3CG	PIK3CG	1455	0.36	0.29	YES
6	PIK3R5	PIK3R5	PIK3R5	1567	0.34	0.33	YES
7	LEF1	LEF1	LEF1	2100	0.28	0.33	YES
8	SPI1	SPI1	SPI1	2139	0.27	0.37	YES
9	PIK3CD	PIK3CD	PIK3CD	2163	0.27	0.4	YES
10	TCF7L1	TCF7L1	TCF7L1	2487	0.24	0.42	YES
11	KIT	KIT	KIT	2561	0.23	0.44	YES
12	FLT3	FLT3	FLT3	2647	0.22	0.47	YES
13	PIK3CA	PIK3CA	PIK3CA	3142	0.18	0.46	YES
14	PIM1	PIM1	PIM1	3183	0.18	0.48	YES
15	RUNX1	RUNX1	RUNX1	3796	0.14	0.47	NO
16	SOS2	SOS2	SOS2	4099	0.13	0.47	NO
17	SOS1	SOS1	SOS1	4575	0.11	0.46	NO
18	BRAF	BRAF	BRAF	5099	0.098	0.44	NO
19	PIK3R1	PIK3R1	PIK3R1	5574	0.085	0.43	NO
20	PIK3R3	PIK3R3	PIK3R3	5593	0.084	0.44	NO
21	RPS6KB1	RPS6KB1	RPS6KB1	5631	0.083	0.44	NO
22	CCND1	CCND1	CCND1	6399	0.066	0.41	NO
23	KRAS	KRAS	KRAS	6580	0.062	0.41	NO
24	STAT5B	STAT5B	STAT5B	6690	0.06	0.41	NO
25	PIK3CB	PIK3CB	PIK3CB	6898	0.056	0.41	NO
26	NRAS	NRAS	NRAS	6951	0.056	0.41	NO
27	RARA	RARA	RARA	7288	0.049	0.4	NO
28	MAP2K1	MAP2K1	MAP2K1	7482	0.046	0.39	NO
29	MAPK1	MAPK1	MAPK1	7616	0.043	0.39	NO
30	STAT5A	STAT5A	STAT5A	7954	0.038	0.38	NO
31	IKBKB	IKBKB	IKBKB	8179	0.034	0.37	NO
32	STAT3	STAT3	STAT3	8346	0.031	0.37	NO
33	NFKB1	NFKB1	NFKB1	8473	0.029	0.36	NO
34	CHUK	CHUK	CHUK	8569	0.028	0.36	NO
35	TCF7	TCF7	TCF7	8941	0.021	0.34	NO
36	GRB2	GRB2	GRB2	8992	0.02	0.34	NO
37	PML	PML	PML	9130	0.018	0.34	NO
38	RELA	RELA	RELA	9233	0.016	0.33	NO
39	MTOR	MTOR	MTOR	9823	0.006	0.3	NO
40	RAF1	RAF1	RAF1	10109	0.0014	0.29	NO
41	TCF7L2	TCF7L2	TCF7L2	10507	-0.0054	0.26	NO
42	AKT1	AKT1	AKT1	11433	-0.022	0.22	NO
43	AKT2	AKT2	AKT2	11925	-0.03	0.19	NO
44	PIM2	PIM2	PIM2	12227	-0.035	0.18	NO
45	IKBKG	IKBKG	IKBKG	12339	-0.038	0.18	NO
46	MAPK3	MAPK3	MAPK3	12556	-0.042	0.17	NO
47	JUP	JUP	JUP	13228	-0.055	0.14	NO
48	MYC	MYC	MYC	14032	-0.074	0.11	NO
49	PIK3R2	PIK3R2	PIK3R2	14099	-0.075	0.12	NO
50	CEBPA	CEBPA	CEBPA	14215	-0.078	0.12	NO
51	BAD	BAD	BAD	14823	-0.097	0.098	NO
52	HRAS	HRAS	HRAS	14840	-0.097	0.11	NO
53	MAP2K2	MAP2K2	MAP2K2	15004	-0.1	0.11	NO
54	ARAF	ARAF	ARAF	15092	-0.11	0.12	NO
55	RPS6KB2	RPS6KB2	RPS6KB2	16063	-0.15	0.089	NO
56	EIF4EBP1	EIF4EBP1	EIF4EBP1	16515	-0.18	0.087	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA BCR PATHWAY	33	genes.ES.table	0.55	1.6	0.058	0.27	0.63	0.48	0.28	0.35	0.13	0.057
BIOCARTA HDAC PATHWAY	26	genes.ES.table	0.57	1.7	0.015	0.25	0.57	0.58	0.34	0.38	0.1	0.052
BIOCARTA EGF PATHWAY	30	genes.ES.table	0.5	1.7	0.017	0.24	0.46	0.57	0.35	0.37	0	0.053
BIOCARTA FCER1 PATHWAY	37	genes.ES.table	0.53	1.6	0.049	0.29	0.72	0.6	0.34	0.39	0.16	0.058
BIOCARTA HIVNEF PATHWAY	57	genes.ES.table	0.4	1.9	0.0099	0.29	0.16	0.49	0.36	0.31	0	0.089
BIOCARTA DEATH PATHWAY	32	genes.ES.table	0.43	1.7	0.017	0.27	0.44	0.53	0.32	0.36	0	0.064
BIOCARTA KERATINOCYTE PATHWAY	45	genes.ES.table	0.48	1.8	0.0085	0.25	0.35	0.49	0.29	0.35	0	0.061
BIOCARTA PYK2 PATHWAY	27	genes.ES.table	0.47	1.9	0.0042	0.25	0.2	0.67	0.42	0.39	0	0.08
BIOCARTA PPARA PATHWAY	55	genes.ES.table	0.5	1.8	0.0022	0.22	0.36	0.62	0.32	0.42	0	0.047
BIOCARTA VIP PATHWAY	25	genes.ES.table	0.59	1.7	0.0086	0.25	0.55	0.6	0.28	0.43	0.1	0.057

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIK3CG	PIK3CG	PIK3CG	200	0.52	0.099	YES
2	PLCE1	PLCE1	PLCE1	651	0.34	0.14	YES
3	PLCG2	PLCG2	PLCG2	968	0.27	0.18	YES
4	ITPKA	ITPKA	ITPKA	1067	0.25	0.23	YES
5	IPMK	IPMK	IPMK	1339	0.21	0.26	YES
6	IMPA1	IMPA1	IMPA1	1438	0.2	0.3	YES
7	SYNJ1	SYNJ1	SYNJ1	1520	0.19	0.33	YES
8	PIK3CD	PIK3CD	PIK3CD	1989	0.16	0.34	YES
9	PIP5K1B	PIP5K1B	PIP5K1B	2089	0.15	0.37	YES
10	PLCB1	PLCB1	PLCB1	2466	0.13	0.37	YES
11	PIKFYVE	PIKFYVE	PIKFYVE	2733	0.12	0.38	YES
12	INPP1	INPP1	INPP1	2916	0.12	0.4	YES
13	ALDH6A1	ALDH6A1	ALDH6A1	3289	0.1	0.4	YES
14	PLCD3	PLCD3	PLCD3	3393	0.1	0.41	YES
15	SYNJ2	SYNJ2	SYNJ2	3631	0.094	0.42	YES
16	PIK3CA	PIK3CA	PIK3CA	3678	0.093	0.44	YES
17	PIP4K2A	PIP4K2A	PIP4K2A	3907	0.087	0.44	YES
18	PIK3C2A	PIK3C2A	PIK3C2A	3932	0.086	0.46	YES
19	PIK3C3	PIK3C3	PIK3C3	4101	0.083	0.47	YES
20	PLCD1	PLCD1	PLCD1	4303	0.078	0.47	YES
21	PTEN	PTEN	PTEN	4332	0.078	0.49	YES
22	PIK3CB	PIK3CB	PIK3CB	4437	0.076	0.5	YES
23	MINPP1	MINPP1	MINPP1	5230	0.06	0.47	NO
24	PIP4K2C	PIP4K2C	PIP4K2C	5562	0.055	0.46	NO
25	INPP4B	INPP4B	INPP4B	5759	0.051	0.46	NO
26	PIK3C2B	PIK3C2B	PIK3C2B	5870	0.05	0.46	NO
27	PLCB4	PLCB4	PLCB4	5998	0.048	0.47	NO
28	PLCB2	PLCB2	PLCB2	6110	0.046	0.47	NO
29	IMPA2	IMPA2	IMPA2	6396	0.041	0.46	NO
30	PI4KA	PI4KA	PI4KA	6433	0.041	0.47	NO
31	ITPKB	ITPKB	ITPKB	6861	0.034	0.45	NO
32	PIP5K1A	PIP5K1A	PIP5K1A	6942	0.033	0.46	NO
33	INPP4A	INPP4A	INPP4A	7320	0.027	0.44	NO
34	IPPK	IPPK	IPPK	7763	0.02	0.42	NO
35	PI4KB	PI4KB	PI4KB	8029	0.017	0.41	NO
36	INPP5A	INPP5A	INPP5A	8240	0.014	0.4	NO
37	ITPK1	ITPK1	ITPK1	8493	0.01	0.39	NO
38	PLCB3	PLCB3	PLCB3	8558	0.0093	0.39	NO
39	INPP5K	INPP5K	INPP5K	9135	0.0015	0.35	NO
40	PIP4K2B	PIP4K2B	PIP4K2B	9902	-0.01	0.31	NO
41	OCRL	OCRL	OCRL	9961	-0.011	0.31	NO
42	PLCD4	PLCD4	PLCD4	10013	-0.012	0.31	NO
43	INPPL1	INPPL1	INPPL1	10483	-0.018	0.29	NO
44	PIP5K1C	PIP5K1C	PIP5K1C	11370	-0.032	0.25	NO
45	INPP5J	INPP5J	INPP5J	11951	-0.041	0.22	NO
46	PLCG1	PLCG1	PLCG1	12207	-0.046	0.22	NO
47	INPP5B	INPP5B	INPP5B	12231	-0.046	0.23	NO
48	TPI1	TPI1	TPI1	12790	-0.057	0.21	NO
49	CDIPT	CDIPT	CDIPT	13076	-0.062	0.21	NO
50	MIOX	MIOX	MIOX	14112	-0.087	0.17	NO
51	INPP5E	INPP5E	INPP5E	15200	-0.12	0.13	NO
52	ISYNA1	ISYNA1	ISYNA1	15385	-0.13	0.15	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FAS	FAS	FAS	913	0.28	0.03	YES
2	BIRC3	BIRC3	BIRC3	1254	0.22	0.076	YES
3	CASP7	CASP7	CASP7	1280	0.22	0.14	YES
4	BCL2	BCL2	BCL2	1408	0.21	0.19	YES
5	GSN	GSN	GSN	2199	0.14	0.19	YES
6	CHUK	CHUK	CHUK	2745	0.12	0.19	YES
7	MAP3K5	MAP3K5	MAP3K5	3340	0.1	0.19	YES
8	PSEN1	PSEN1	PSEN1	3482	0.098	0.21	YES
9	MAP3K1	MAP3K1	MAP3K1	3605	0.095	0.23	YES
10	APAF1	APAF1	APAF1	3628	0.094	0.26	YES
11	CASP3	CASP3	CASP3	4027	0.085	0.26	YES
12	BIRC2	BIRC2	BIRC2	4162	0.081	0.27	YES
13	MAP3K14	MAP3K14	MAP3K14	4442	0.076	0.28	YES
14	RB1	RB1	RB1	4451	0.076	0.3	YES
15	NFKB1	NFKB1	NFKB1	4759	0.069	0.3	YES
16	RIPK1	RIPK1	RIPK1	4818	0.067	0.32	YES
17	CASP8	CASP8	CASP8	4831	0.067	0.34	YES
18	XIAP	XIAP	XIAP	5008	0.064	0.35	YES
19	MAPK8	MAPK8	MAPK8	5067	0.063	0.36	YES
20	CFLAR	CFLAR	CFLAR	5210	0.06	0.37	YES
21	RASA1	RASA1	RASA1	5293	0.059	0.38	YES
22	SPTAN1	SPTAN1	SPTAN1	5725	0.052	0.38	YES
23	CYCS	CYCS	CYCS	5760	0.051	0.39	YES
24	PAK2	PAK2	PAK2	6065	0.047	0.38	YES
25	MDM2	MDM2	MDM2	6361	0.042	0.38	YES
26	BAG4	BAG4	BAG4	6474	0.04	0.39	YES
27	TRAF1	TRAF1	TRAF1	6507	0.04	0.4	YES
28	CASP9	CASP9	CASP9	6601	0.038	0.4	YES
29	TNFRSF1B	TNFRSF1B	TNFRSF1B	7368	0.026	0.37	NO
30	PARP1	PARP1	PARP1	7513	0.024	0.37	NO
31	CRADD	CRADD	CRADD	7701	0.022	0.36	NO
32	PRKDC	PRKDC	PRKDC	7926	0.018	0.35	NO
33	MAP2K7	MAP2K7	MAP2K7	7967	0.017	0.36	NO
34	DAXX	DAXX	DAXX	8040	0.016	0.36	NO
35	PRKCD	PRKCD	PRKCD	8131	0.015	0.36	NO
36	TNF	TNF	TNF	8213	0.014	0.36	NO
37	TNFRSF1A	TNFRSF1A	TNFRSF1A	8226	0.014	0.36	NO
38	NUMA1	NUMA1	NUMA1	8420	0.011	0.35	NO
39	CASP6	CASP6	CASP6	8605	0.0086	0.34	NO
40	ARHGDIB	ARHGDIB	ARHGDIB	9186	0.0008	0.31	NO
41	CASP2	CASP2	CASP2	9331	-0.0013	0.3	NO
42	LMNA	LMNA	LMNA	9458	-0.0031	0.3	NO
43	LMNB1	LMNB1	LMNB1	9862	-0.0095	0.28	NO
44	CDK11B	CDK11B	CDK11B	10085	-0.013	0.27	NO
45	LMNB2	LMNB2	LMNB2	10104	-0.013	0.27	NO
46	TRAF2	TRAF2	TRAF2	10284	-0.016	0.27	NO
47	PTK2	PTK2	PTK2	10389	-0.017	0.27	NO
48	RELA	RELA	RELA	10621	-0.02	0.26	NO
49	PSEN2	PSEN2	PSEN2	10762	-0.022	0.26	NO
50	NFKBIA	NFKBIA	NFKBIA	10972	-0.026	0.26	NO
51	CDK11A	CDK11A	CDK11A	11534	-0.035	0.23	NO
52	ACTG1	ACTG1	ACTG1	12010	-0.042	0.22	NO
53	DFFA	DFFA	DFFA	12205	-0.046	0.22	NO
54	FADD	FADD	FADD	12867	-0.058	0.2	NO
55	DFFB	DFFB	DFFB	14078	-0.086	0.16	NO
56	BID	BID	BID	14446	-0.096	0.17	NO
57	TRADD	TRADD	TRADD	15115	-0.12	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	507	0.38	0.19	YES
2	PTK2B	PTK2B	PTK2B	1671	0.18	0.23	YES
3	GNAQ	GNAQ	GNAQ	2508	0.13	0.26	YES
4	SOS1	SOS1	SOS1	3531	0.096	0.26	YES
5	MAP3K1	MAP3K1	MAP3K1	3605	0.095	0.31	YES
6	PRKCA	PRKCA	PRKCA	3679	0.093	0.36	YES
7	MAPK3	MAPK3	MAPK3	4650	0.071	0.34	YES
8	CALM2	CALM2	CALM2	4913	0.066	0.36	YES
9	MAP2K1	MAP2K1	MAP2K1	4988	0.064	0.4	YES
10	MAPK8	MAPK8	MAPK8	5067	0.063	0.43	YES
11	MAPK1	MAPK1	MAPK1	5534	0.055	0.44	YES
12	PAK1	PAK1	PAK1	5919	0.049	0.44	YES
13	MAPK14	MAPK14	MAPK14	6186	0.044	0.45	YES
14	CALM1	CALM1	CALM1	6689	0.037	0.45	YES
15	GRB2	GRB2	GRB2	6983	0.032	0.45	YES
16	SHC1	SHC1	SHC1	7007	0.032	0.46	YES
17	CRKL	CRKL	CRKL	7322	0.027	0.46	YES
18	MAP2K4	MAP2K4	MAP2K4	7518	0.024	0.47	YES
19	SRC	SRC	SRC	8149	0.015	0.44	NO
20	RAF1	RAF1	RAF1	8377	0.012	0.43	NO
21	CALM3	CALM3	CALM3	8595	0.0088	0.43	NO
22	RAC1	RAC1	RAC1	9404	-0.0024	0.38	NO
23	MAP2K3	MAP2K3	MAP2K3	9486	-0.0036	0.38	NO
24	BCAR1	BCAR1	BCAR1	9906	-0.01	0.36	NO
25	MAP2K2	MAP2K2	MAP2K2	11467	-0.034	0.3	NO
26	PLCG1	PLCG1	PLCG1	12207	-0.046	0.28	NO
27	JUN	JUN	JUN	13628	-0.075	0.25	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TUSC3	TUSC3	TUSC3	725	0.32	0.065	YES
2	MGAT5	MGAT5	MGAT5	1523	0.19	0.085	YES
3	MGAT3	MGAT3	MGAT3	1598	0.19	0.14	YES
4	MAN2A1	MAN2A1	MAN2A1	1630	0.19	0.2	YES
5	MAN1A2	MAN1A2	MAN1A2	1631	0.19	0.26	YES
6	MGAT4A	MGAT4A	MGAT4A	2101	0.15	0.29	YES
7	ALG11	ALG11	ALG11	2104	0.15	0.34	YES
8	MAN1A1	MAN1A1	MAN1A1	2410	0.14	0.36	YES
9	MAN1C1	MAN1C1	MAN1C1	3201	0.11	0.36	YES
10	ALG6	ALG6	ALG6	3440	0.099	0.38	YES
11	ST6GAL1	ST6GAL1	ST6GAL1	4148	0.082	0.36	YES
12	DOLPP1	DOLPP1	DOLPP1	4185	0.081	0.39	YES
13	B4GALT1	B4GALT1	B4GALT1	4283	0.079	0.41	YES
14	MGAT2	MGAT2	MGAT2	5372	0.057	0.37	NO
15	ALG10	ALG10	ALG10	5424	0.057	0.38	NO
16	ALG10B	ALG10B	ALG10B	5790	0.051	0.38	NO
17	ALG14	ALG14	ALG14	6084	0.046	0.38	NO
18	STT3B	STT3B	STT3B	6273	0.043	0.38	NO
19	ALG5	ALG5	ALG5	6323	0.043	0.4	NO
20	MAN2A2	MAN2A2	MAN2A2	7145	0.03	0.36	NO
21	ALG13	ALG13	ALG13	7775	0.02	0.33	NO
22	ALG2	ALG2	ALG2	7791	0.02	0.34	NO
23	STT3A	STT3A	STT3A	8441	0.011	0.3	NO
24	ALG8	ALG8	ALG8	8840	0.0054	0.28	NO
25	DPM1	DPM1	DPM1	9422	-0.0026	0.25	NO
26	GANAB	GANAB	GANAB	9513	-0.0041	0.25	NO
27	FUT8	FUT8	FUT8	9669	-0.0064	0.24	NO
28	MOGS	MOGS	MOGS	9693	-0.0067	0.24	NO
29	B4GALT3	B4GALT3	B4GALT3	9757	-0.0076	0.24	NO
30	ALG1	ALG1	ALG1	10627	-0.02	0.2	NO
31	MGAT1	MGAT1	MGAT1	10637	-0.021	0.21	NO
32	RPN2	RPN2	RPN2	10669	-0.021	0.21	NO
33	ALG9	ALG9	ALG9	10832	-0.024	0.21	NO
34	MGAT4B	MGAT4B	MGAT4B	10836	-0.024	0.22	NO
35	DAD1	DAD1	DAD1	10910	-0.025	0.22	NO
36	DDOST	DDOST	DDOST	11022	-0.026	0.23	NO
37	MAN1B1	MAN1B1	MAN1B1	11029	-0.026	0.23	NO
38	DPAGT1	DPAGT1	DPAGT1	11499	-0.034	0.22	NO
39	RPN1	RPN1	RPN1	11786	-0.039	0.22	NO
40	MGAT5B	MGAT5B	MGAT5B	12247	-0.047	0.21	NO
41	ALG12	ALG12	ALG12	12823	-0.058	0.19	NO
42	B4GALT2	B4GALT2	B4GALT2	13093	-0.063	0.2	NO
43	ALG3	ALG3	ALG3	13649	-0.075	0.19	NO
44	DPM2	DPM2	DPM2	13650	-0.075	0.22	NO
45	DPM3	DPM3	DPM3	13979	-0.083	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIK3CG	PIK3CG	PIK3CG	200	0.52	0.15	YES
2	MAP4K1	MAP4K1	MAP4K1	930	0.28	0.19	YES
3	HGF	HGF	HGF	1029	0.26	0.26	YES
4	PTK2B	PTK2B	PTK2B	1671	0.18	0.28	YES
5	GAB1	GAB1	GAB1	1812	0.17	0.32	YES
6	ITGA1	ITGA1	ITGA1	2655	0.12	0.32	YES
7	RAP1A	RAP1A	RAP1A	2683	0.12	0.35	YES
8	SOS1	SOS1	SOS1	3531	0.096	0.33	YES
9	PIK3CA	PIK3CA	PIK3CA	3678	0.093	0.35	YES
10	DOCK1	DOCK1	DOCK1	4222	0.08	0.35	YES
11	PTEN	PTEN	PTEN	4332	0.078	0.36	YES
12	STAT3	STAT3	STAT3	4390	0.077	0.38	YES
13	MAPK3	MAPK3	MAPK3	4650	0.071	0.39	YES
14	RAPGEF1	RAPGEF1	RAPGEF1	4652	0.071	0.41	YES
15	CRK	CRK	CRK	4716	0.07	0.43	YES
16	MAP2K1	MAP2K1	MAP2K1	4988	0.064	0.44	YES
17	MAPK8	MAPK8	MAPK8	5067	0.063	0.45	YES
18	RASA1	RASA1	RASA1	5293	0.059	0.46	YES
19	MAPK1	MAPK1	MAPK1	5534	0.055	0.46	YES
20	PIK3R1	PIK3R1	PIK3R1	5695	0.053	0.47	YES
21	RAP1B	RAP1B	RAP1B	5811	0.05	0.47	YES
22	PTPN11	PTPN11	PTPN11	5899	0.049	0.48	YES
23	PAK1	PAK1	PAK1	5919	0.049	0.5	YES
24	PXN	PXN	PXN	5987	0.048	0.51	YES
25	FOS	FOS	FOS	6146	0.045	0.51	YES
26	ITGB1	ITGB1	ITGB1	6747	0.036	0.49	NO
27	GRB2	GRB2	GRB2	6983	0.032	0.49	NO
28	CRKL	CRKL	CRKL	7322	0.027	0.48	NO
29	SRC	SRC	SRC	8149	0.015	0.44	NO
30	MET	MET	MET	8219	0.014	0.44	NO
31	RAF1	RAF1	RAF1	8377	0.012	0.43	NO
32	PTK2	PTK2	PTK2	10389	-0.017	0.32	NO
33	MAP2K2	MAP2K2	MAP2K2	11467	-0.034	0.28	NO
34	ELK1	ELK1	ELK1	11878	-0.04	0.26	NO
35	JUN	JUN	JUN	13628	-0.075	0.19	NO
36	ACTA1	ACTA1	ACTA1	16304	-0.19	0.099	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	507	0.38	0.071	YES
2	FAS	FAS	FAS	913	0.28	0.12	YES
3	FASLG	FASLG	FASLG	1019	0.26	0.18	YES
4	BCL2	BCL2	BCL2	1408	0.21	0.22	YES
5	EGFR	EGFR	EGFR	1719	0.18	0.25	YES
6	ETS1	ETS1	ETS1	1969	0.16	0.28	YES
7	HOXA7	HOXA7	HOXA7	2032	0.16	0.31	YES
8	EGF	EGF	EGF	2289	0.14	0.34	YES
9	CHUK	CHUK	CHUK	2745	0.12	0.34	YES
10	PRKCH	PRKCH	PRKCH	2773	0.12	0.37	YES
11	MAP3K5	MAP3K5	MAP3K5	3340	0.1	0.37	YES
12	MAP3K1	MAP3K1	MAP3K1	3605	0.095	0.38	YES
13	PRKCA	PRKCA	PRKCA	3679	0.093	0.4	YES
14	PRKCE	PRKCE	PRKCE	3935	0.086	0.41	YES
15	MAP3K14	MAP3K14	MAP3K14	4442	0.076	0.4	YES
16	MAP2K6	MAP2K6	MAP2K6	4525	0.074	0.41	YES
17	MAPK3	MAPK3	MAPK3	4650	0.071	0.42	YES
18	NFKB1	NFKB1	NFKB1	4759	0.069	0.44	YES
19	RIPK1	RIPK1	RIPK1	4818	0.067	0.45	YES
20	MAP2K1	MAP2K1	MAP2K1	4988	0.064	0.46	YES
21	MAPK8	MAPK8	MAPK8	5067	0.063	0.47	YES
22	SP1	SP1	SP1	5189	0.061	0.48	YES
23	MAPK1	MAPK1	MAPK1	5534	0.055	0.48	NO
24	FOS	FOS	FOS	6146	0.045	0.45	NO
25	MAPK14	MAPK14	MAPK14	6186	0.044	0.46	NO
26	MAPK13	MAPK13	MAPK13	6252	0.044	0.47	NO
27	TNFRSF1B	TNFRSF1B	TNFRSF1B	7368	0.026	0.42	NO
28	MAP2K4	MAP2K4	MAP2K4	7518	0.024	0.41	NO
29	MAP2K7	MAP2K7	MAP2K7	7967	0.017	0.39	NO
30	DAXX	DAXX	DAXX	8040	0.016	0.39	NO
31	PRKCD	PRKCD	PRKCD	8131	0.015	0.39	NO
32	TNF	TNF	TNF	8213	0.014	0.39	NO
33	TNFRSF1A	TNFRSF1A	TNFRSF1A	8226	0.014	0.4	NO
34	RAF1	RAF1	RAF1	8377	0.012	0.39	NO
35	CEBPA	CEBPA	CEBPA	9316	-0.0011	0.34	NO
36	MAP2K3	MAP2K3	MAP2K3	9486	-0.0036	0.33	NO
37	ETS2	ETS2	ETS2	9699	-0.0068	0.32	NO
38	PPP2CA	PPP2CA	PPP2CA	9803	-0.0084	0.32	NO
39	IKBKB	IKBKB	IKBKB	9979	-0.011	0.31	NO
40	RELA	RELA	RELA	10621	-0.02	0.28	NO
41	NFKBIA	NFKBIA	NFKBIA	10972	-0.026	0.27	NO
42	PRKCQ	PRKCQ	PRKCQ	12509	-0.051	0.2	NO
43	JUN	JUN	JUN	13628	-0.075	0.15	NO
44	HRAS	HRAS	HRAS	15203	-0.12	0.098	NO
45	PRKCG	PRKCG	PRKCG	16873	-0.24	0.067	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIK3CG	PIK3CG	PIK3CG	200	0.52	0.074	YES
2	PRKAR2B	PRKAR2B	PRKAR2B	403	0.42	0.13	YES
3	PRKCB	PRKCB	PRKCB	507	0.38	0.19	YES
4	PPARGC1A	PPARGC1A	PPARGC1A	512	0.38	0.25	YES
5	CD36	CD36	CD36	532	0.37	0.31	YES
6	NOS2	NOS2	NOS2	554	0.36	0.36	YES
7	PRKACB	PRKACB	PRKACB	951	0.27	0.39	YES
8	FABP1	FABP1	FABP1	1735	0.18	0.37	YES
9	CITED2	CITED2	CITED2	2395	0.14	0.36	YES
10	EHHADH	EHHADH	EHHADH	2428	0.13	0.38	YES
11	PDGFA	PDGFA	PDGFA	2763	0.12	0.38	YES
12	PTGS2	PTGS2	PTGS2	2791	0.12	0.4	YES
13	NRIP1	NRIP1	NRIP1	2930	0.11	0.41	YES
14	NCOA1	NCOA1	NCOA1	3124	0.11	0.41	YES
15	PIK3CA	PIK3CA	PIK3CA	3678	0.093	0.4	YES
16	PRKCA	PRKCA	PRKCA	3679	0.093	0.41	YES
17	FAT1	FAT1	FAT1	3838	0.089	0.42	YES
18	PPARA	PPARA	PPARA	3918	0.087	0.43	YES
19	MED1	MED1	MED1	3951	0.086	0.44	YES
20	ME1	ME1	ME1	3985	0.086	0.45	YES
21	NR0B2	NR0B2	NR0B2	4120	0.083	0.46	YES
22	EP300	EP300	EP300	4337	0.078	0.46	YES
23	NCOR1	NCOR1	NCOR1	4381	0.077	0.47	YES
24	RB1	RB1	RB1	4451	0.076	0.48	YES
25	MAPK3	MAPK3	MAPK3	4650	0.071	0.48	YES
26	PRKAR1A	PRKAR1A	PRKAR1A	4987	0.064	0.47	YES
27	PRKAR2A	PRKAR2A	PRKAR2A	5104	0.062	0.47	YES
28	RXRA	RXRA	RXRA	5139	0.062	0.48	YES
29	SP1	SP1	SP1	5189	0.061	0.49	YES
30	CREBBP	CREBBP	CREBBP	5439	0.056	0.48	YES
31	HSD17B4	HSD17B4	HSD17B4	5441	0.056	0.49	YES
32	MAPK1	MAPK1	MAPK1	5534	0.055	0.5	YES
33	PRKACG	PRKACG	PRKACG	5657	0.053	0.5	YES
34	PIK3R1	PIK3R1	PIK3R1	5695	0.053	0.5	YES
35	HSP90AA1	HSP90AA1	HSP90AA1	7464	0.025	0.41	NO
36	DUSP1	DUSP1	DUSP1	7814	0.02	0.4	NO
37	STAT5B	STAT5B	STAT5B	8098	0.016	0.38	NO
38	TNF	TNF	TNF	8213	0.014	0.38	NO
39	HSPA1A	HSPA1A	HSPA1A	8650	0.0081	0.35	NO
40	MYC	MYC	MYC	9940	-0.011	0.28	NO
41	APOA1	APOA1	APOA1	10053	-0.013	0.28	NO
42	NCOR2	NCOR2	NCOR2	10089	-0.013	0.28	NO
43	STAT5A	STAT5A	STAT5A	10425	-0.018	0.26	NO
44	RELA	RELA	RELA	10621	-0.02	0.26	NO
45	NFKBIA	NFKBIA	NFKBIA	10972	-0.026	0.24	NO
46	NR2F1	NR2F1	NR2F1	12386	-0.049	0.17	NO
47	PRKAR1B	PRKAR1B	PRKAR1B	13082	-0.063	0.14	NO
48	SRA1	SRA1	SRA1	13627	-0.075	0.12	NO
49	JUN	JUN	JUN	13628	-0.075	0.14	NO
50	NR1H3	NR1H3	NR1H3	13993	-0.083	0.13	NO
51	LPL	LPL	LPL	14431	-0.096	0.12	NO
52	MRPL11	MRPL11	MRPL11	14472	-0.097	0.14	NO
53	DUT	DUT	DUT	14727	-0.1	0.14	NO
54	APOA2	APOA2	APOA2	15026	-0.12	0.14	NO
55	CPT1B	CPT1B	CPT1B	16203	-0.18	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BIRC3	BIRC3	BIRC3	1254	0.22	0.019	YES
2	CASP7	CASP7	CASP7	1280	0.22	0.1	YES
3	BCL2	BCL2	BCL2	1408	0.21	0.18	YES
4	CASP10	CASP10	CASP10	1558	0.19	0.24	YES
5	TNFSF10	TNFSF10	TNFSF10	1780	0.17	0.3	YES
6	CHUK	CHUK	CHUK	2745	0.12	0.3	YES
7	APAF1	APAF1	APAF1	3628	0.094	0.28	YES
8	CASP3	CASP3	CASP3	4027	0.085	0.29	YES
9	BIRC2	BIRC2	BIRC2	4162	0.081	0.32	YES
10	MAP3K14	MAP3K14	MAP3K14	4442	0.076	0.33	YES
11	NFKB1	NFKB1	NFKB1	4759	0.069	0.34	YES
12	RIPK1	RIPK1	RIPK1	4818	0.067	0.37	YES
13	CASP8	CASP8	CASP8	4831	0.067	0.39	YES
14	XIAP	XIAP	XIAP	5008	0.064	0.41	YES
15	CFLAR	CFLAR	CFLAR	5210	0.06	0.42	YES
16	SPTAN1	SPTAN1	SPTAN1	5725	0.052	0.41	YES
17	CYCS	CYCS	CYCS	5760	0.051	0.43	YES
18	CASP9	CASP9	CASP9	6601	0.038	0.4	NO
19	TNFRSF10A	TNFRSF10A	TNFRSF10A	7959	0.018	0.33	NO
20	CASP6	CASP6	CASP6	8605	0.0086	0.3	NO
21	TNFRSF10B	TNFRSF10B	TNFRSF10B	9272	-0.00059	0.26	NO
22	LMNA	LMNA	LMNA	9458	-0.0031	0.25	NO
23	TRAF2	TRAF2	TRAF2	10284	-0.016	0.21	NO
24	RELA	RELA	RELA	10621	-0.02	0.2	NO
25	TNFSF12	TNFSF12	TNFSF12	10680	-0.021	0.21	NO
26	NFKBIA	NFKBIA	NFKBIA	10972	-0.026	0.2	NO
27	DFFA	DFFA	DFFA	12205	-0.046	0.15	NO
28	TNFRSF25	TNFRSF25	TNFRSF25	12682	-0.054	0.15	NO
29	FADD	FADD	FADD	12867	-0.058	0.16	NO
30	DFFB	DFFB	DFFB	14078	-0.086	0.13	NO
31	TRADD	TRADD	TRADD	15115	-0.12	0.12	NO
32	GAS2	GAS2	GAS2	15236	-0.12	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKAR2B	PRKAR2B	PRKAR2B	403	0.42	0.14	YES
2	PRKCB	PRKCB	PRKCB	507	0.38	0.27	YES
3	PRKACB	PRKACB	PRKACB	951	0.27	0.35	YES
4	RPS6KA5	RPS6KA5	RPS6KA5	1248	0.22	0.42	YES
5	CAMK2D	CAMK2D	CAMK2D	2593	0.13	0.39	YES
6	SOS1	SOS1	SOS1	3531	0.096	0.38	YES
7	PIK3CA	PIK3CA	PIK3CA	3678	0.093	0.4	YES
8	PRKCA	PRKCA	PRKCA	3679	0.093	0.44	YES
9	CAMK2B	CAMK2B	CAMK2B	4075	0.084	0.45	YES
10	MAPK3	MAPK3	MAPK3	4650	0.071	0.44	YES
11	PRKAR1A	PRKAR1A	PRKAR1A	4987	0.064	0.45	YES
12	CREB1	CREB1	CREB1	5069	0.063	0.47	YES
13	PRKAR2A	PRKAR2A	PRKAR2A	5104	0.062	0.49	YES
14	MAPK1	MAPK1	MAPK1	5534	0.055	0.49	YES
15	PRKACG	PRKACG	PRKACG	5657	0.053	0.5	YES
16	PIK3R1	PIK3R1	PIK3R1	5695	0.053	0.52	YES
17	CAMK2A	CAMK2A	CAMK2A	5717	0.052	0.54	YES
18	MAPK14	MAPK14	MAPK14	6186	0.044	0.53	NO
19	RPS6KA1	RPS6KA1	RPS6KA1	6636	0.038	0.52	NO
20	GRB2	GRB2	GRB2	6983	0.032	0.51	NO
21	CAMK2G	CAMK2G	CAMK2G	8847	0.0053	0.41	NO
22	RAC1	RAC1	RAC1	9404	-0.0024	0.38	NO
23	AKT1	AKT1	AKT1	9581	-0.005	0.37	NO
24	PRKAR1B	PRKAR1B	PRKAR1B	13082	-0.063	0.2	NO
25	GNAS	GNAS	GNAS	13560	-0.073	0.2	NO
26	HRAS	HRAS	HRAS	15203	-0.12	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKCB	PRKCB	PRKCB	507	0.38	0.14	YES
2	STAT4	STAT4	STAT4	1264	0.22	0.2	YES
3	EGFR	EGFR	EGFR	1719	0.18	0.26	YES
4	EGF	EGF	EGF	2289	0.14	0.29	YES
5	SOS1	SOS1	SOS1	3531	0.096	0.27	YES
6	MAP3K1	MAP3K1	MAP3K1	3605	0.095	0.31	YES
7	PIK3CA	PIK3CA	PIK3CA	3678	0.093	0.35	YES
8	PRKCA	PRKCA	PRKCA	3679	0.093	0.39	YES
9	JAK1	JAK1	JAK1	3850	0.088	0.42	YES
10	STAT3	STAT3	STAT3	4390	0.077	0.42	YES
11	MAPK3	MAPK3	MAPK3	4650	0.071	0.44	YES
12	MAP2K1	MAP2K1	MAP2K1	4988	0.064	0.45	YES
13	MAPK8	MAPK8	MAPK8	5067	0.063	0.48	YES
14	RASA1	RASA1	RASA1	5293	0.059	0.49	YES
15	PIK3R1	PIK3R1	PIK3R1	5695	0.053	0.49	YES
16	FOS	FOS	FOS	6146	0.045	0.49	YES
17	STAT1	STAT1	STAT1	6272	0.043	0.5	YES
18	GRB2	GRB2	GRB2	6983	0.032	0.48	NO
19	SHC1	SHC1	SHC1	7007	0.032	0.49	NO
20	MAP2K4	MAP2K4	MAP2K4	7518	0.024	0.47	NO
21	STAT5B	STAT5B	STAT5B	8098	0.016	0.45	NO
22	SRF	SRF	SRF	8329	0.012	0.44	NO
23	RAF1	RAF1	RAF1	8377	0.012	0.44	NO
24	CSNK2A1	CSNK2A1	CSNK2A1	8395	0.012	0.45	NO
25	STAT2	STAT2	STAT2	8545	0.0094	0.44	NO
26	STAT6	STAT6	STAT6	9477	-0.0035	0.4	NO
27	STAT5A	STAT5A	STAT5A	10425	-0.018	0.35	NO
28	ELK1	ELK1	ELK1	11878	-0.04	0.29	NO
29	PLCG1	PLCG1	PLCG1	12207	-0.046	0.29	NO
30	JUN	JUN	JUN	13628	-0.075	0.25	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA FAS PATHWAY	29	genes.ES.table	0.48	1.6	0.048	0.65	0.68	0.59	0.33	0.39	0.33	0.21
BIOCARTA HIVNEF PATHWAY	57	genes.ES.table	0.24	1.1	0.33	1	1	0.44	0.32	0.3	1	0.8
BIOCARTA RACCYCD PATHWAY	25	genes.ES.table	0.25	1.1	0.39	1	1	1	0.75	0.25	1	0.79
BIOCARTA PYK2 PATHWAY	27	genes.ES.table	0.27	1.1	0.36	1	1	1	0.73	0.27	1	0.76
BIOCARTA TNFR1 PATHWAY	28	genes.ES.table	0.31	1.2	0.21	1	1	0.61	0.34	0.4	1	0.68
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION	43	genes.ES.table	0.26	0.94	0.52	1	1	0.46	0.26	0.35	1	0.82
KEGG O GLYCAN BIOSYNTHESIS	28	genes.ES.table	0.37	0.96	0.53	1	1	0.39	0.12	0.34	1	0.85
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES	25	genes.ES.table	0.33	0.92	0.58	1	1	0.32	0.1	0.29	1	0.77
KEGG PROPANOATE METABOLISM	31	genes.ES.table	0.32	1	0.44	1	1	0.48	0.26	0.36	1	0.74
KEGG BUTANOATE METABOLISM	29	genes.ES.table	0.29	0.87	0.63	1	1	0.17	0.087	0.16	1	0.85

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EPRS	EPRS	EPRS	2056	0.095	-0.051	YES
2	DARS2	DARS2	DARS2	2199	0.091	0.00097	YES
3	NARS	NARS	NARS	2296	0.088	0.054	YES
4	SEPSECS	SEPSECS	SEPSECS	2344	0.087	0.11	YES
5	WARS2	WARS2	WARS2	2563	0.082	0.15	YES
6	RARS	RARS	RARS	2569	0.081	0.2	YES
7	YARS2	YARS2	YARS2	2761	0.076	0.24	YES
8	HARS2	HARS2	HARS2	3419	0.064	0.25	YES
9	AARS2	AARS2	AARS2	3533	0.062	0.28	YES
10	MTFMT	MTFMT	MTFMT	3868	0.056	0.3	YES
11	IARS2	IARS2	IARS2	3888	0.056	0.34	YES
12	TARS	TARS	TARS	4121	0.052	0.36	YES
13	YARS	YARS	YARS	4817	0.041	0.35	YES
14	LARS	LARS	LARS	4829	0.04	0.37	YES
15	FARSB	FARSB	FARSB	4969	0.038	0.39	YES
16	DARS	DARS	DARS	5461	0.031	0.38	YES
17	TARSL2	TARSL2	TARSL2	5467	0.031	0.41	YES
18	RARS2	RARS2	RARS2	5490	0.031	0.42	YES
19	IARS	IARS	IARS	5685	0.028	0.43	YES
20	SARS2	SARS2	SARS2	5730	0.027	0.45	YES
21	PSTK	PSTK	PSTK	5823	0.026	0.46	YES
22	MARS2	MARS2	MARS2	6029	0.023	0.46	YES
23	EARS2	EARS2	EARS2	6158	0.021	0.47	YES
24	PARS2	PARS2	PARS2	6490	0.016	0.46	YES
25	LARS2	LARS2	LARS2	6518	0.016	0.47	YES
26	HARS	HARS	HARS	6587	0.015	0.48	YES
27	QARS	QARS	QARS	6751	0.013	0.48	YES
28	KARS	KARS	KARS	6865	0.011	0.48	YES
29	VARS2	VARS2	VARS2	6915	0.01	0.48	YES
30	MARS	MARS	MARS	7224	0.0057	0.47	NO
31	GARS	GARS	GARS	7434	0.0029	0.46	NO
32	VARS	VARS	VARS	7816	-0.0022	0.44	NO
33	WARS	WARS	WARS	8144	-0.0072	0.43	NO
34	FARS2	FARS2	FARS2	8765	-0.016	0.4	NO
35	CARS	CARS	CARS	8827	-0.017	0.41	NO
36	AARS	AARS	AARS	8865	-0.018	0.42	NO
37	SARS	SARS	SARS	9012	-0.02	0.42	NO
38	FARSA	FARSA	FARSA	9129	-0.022	0.43	NO
39	NARS2	NARS2	NARS2	9833	-0.032	0.42	NO
40	CARS2	CARS2	CARS2	11532	-0.063	0.36	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PTPN13	PTPN13	PTPN13	133	0.29	0.19	YES
2	MAP2K4	MAP2K4	MAP2K4	1794	0.1	0.17	YES
3	PARP1	PARP1	PARP1	2021	0.096	0.22	YES
4	CASP3	CASP3	CASP3	2416	0.085	0.26	YES
5	CASP7	CASP7	CASP7	2964	0.072	0.28	YES
6	MAP3K1	MAP3K1	MAP3K1	2966	0.072	0.33	YES
7	PAK2	PAK2	PAK2	3352	0.065	0.35	YES
8	RB1	RB1	RB1	3557	0.061	0.38	YES
9	MAPK8	MAPK8	MAPK8	3880	0.056	0.4	YES
10	PRKDC	PRKDC	PRKDC	4165	0.051	0.42	YES
11	CASP10	CASP10	CASP10	4671	0.043	0.42	YES
12	CASP8	CASP8	CASP8	4843	0.04	0.44	YES
13	FAS	FAS	FAS	5194	0.035	0.44	YES
14	LMNA	LMNA	LMNA	5449	0.031	0.45	YES
15	LMNB2	LMNB2	LMNB2	5598	0.029	0.46	YES
16	SPTAN1	SPTAN1	SPTAN1	5865	0.025	0.46	YES
17	MAP3K7	MAP3K7	MAP3K7	5947	0.024	0.48	YES
18	FAF1	FAF1	FAF1	7075	0.008	0.42	NO
19	CASP6	CASP6	CASP6	7282	0.005	0.41	NO
20	DFFA	DFFA	DFFA	7394	0.0035	0.41	NO
21	DAXX	DAXX	DAXX	7440	0.0029	0.41	NO
22	DFFB	DFFB	DFFB	7735	-0.0013	0.39	NO
23	ARHGDIB	ARHGDIB	ARHGDIB	7739	-0.0013	0.39	NO
24	PAK1	PAK1	PAK1	9096	-0.021	0.33	NO
25	RIPK2	RIPK2	RIPK2	9111	-0.022	0.34	NO
26	FASLG	FASLG	FASLG	10598	-0.045	0.29	NO
27	JUN	JUN	JUN	10633	-0.046	0.32	NO
28	CFLAR	CFLAR	CFLAR	10761	-0.049	0.35	NO
29	FADD	FADD	FADD	12448	-0.084	0.31	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	THOC1	THOC1	THOC1	717	0.17	-0.013	YES
2	RBM25	RBM25	RBM25	1089	0.14	-0.012	YES
3	SNRPD1	SNRPD1	SNRPD1	1190	0.13	0.0031	YES
4	SNRPE	SNRPE	SNRPE	1285	0.12	0.018	YES
5	CDC5L	CDC5L	CDC5L	1770	0.1	0.0073	YES
6	RBM8A	RBM8A	RBM8A	1922	0.099	0.015	YES
7	BCAS2	BCAS2	BCAS2	1948	0.098	0.029	YES
8	SYF2	SYF2	SYF2	1950	0.098	0.044	YES
9	PRPF38B	PRPF38B	PRPF38B	1974	0.098	0.059	YES
10	SNRNP27	SNRNP27	SNRNP27	1984	0.097	0.074	YES
11	LSM6	LSM6	LSM6	1998	0.097	0.088	YES
12	SNRPA1	SNRPA1	SNRPA1	2101	0.094	0.098	YES
13	PRPF18	PRPF18	PRPF18	2273	0.089	0.1	YES
14	SNRPB2	SNRPB2	SNRPB2	2357	0.087	0.11	YES
15	CDC40	CDC40	CDC40	2467	0.084	0.12	YES
16	SNW1	SNW1	SNW1	2478	0.083	0.13	YES
17	TCERG1	TCERG1	TCERG1	2531	0.082	0.14	YES
18	NCBP1	NCBP1	NCBP1	2551	0.082	0.15	YES
19	SLU7	SLU7	SLU7	2596	0.08	0.16	YES
20	HNRNPU	HNRNPU	HNRNPU	2741	0.077	0.17	YES
21	DDX46	DDX46	DDX46	2747	0.077	0.18	YES
22	MAGOHB	MAGOHB	MAGOHB	2813	0.076	0.19	YES
23	CRNKL1	CRNKL1	CRNKL1	2845	0.075	0.2	YES
24	PRPF40A	PRPF40A	PRPF40A	2917	0.074	0.21	YES
25	SR140	SR140	SR140	2993	0.072	0.21	YES
26	HNRNPC	HNRNPC	HNRNPC	3117	0.069	0.22	YES
27	SNRPF	SNRPF	SNRPF	3154	0.069	0.23	YES
28	HNRNPA3	HNRNPA3	HNRNPA3	3190	0.068	0.24	YES
29	LSM3	LSM3	LSM3	3284	0.066	0.24	YES
30	THOC2	THOC2	THOC2	3328	0.066	0.25	YES
31	DHX15	DHX15	DHX15	3404	0.064	0.26	YES
32	SF3A3	SF3A3	SF3A3	3418	0.064	0.26	YES
33	HNRNPK	HNRNPK	HNRNPK	3429	0.064	0.27	YES
34	SMNDC1	SMNDC1	SMNDC1	3488	0.062	0.28	YES
35	SFRS13A	SFRS13A	SFRS13A	3653	0.06	0.28	YES
36	AQR	AQR	AQR	3716	0.058	0.29	YES
37	HNRNPA1	HNRNPA1	HNRNPA1	3820	0.057	0.29	YES
38	PPIH	PPIH	PPIH	3967	0.054	0.29	YES
39	ACIN1	ACIN1	ACIN1	4016	0.054	0.3	YES
40	SF3B1	SF3B1	SF3B1	4068	0.053	0.3	YES
41	LSM5	LSM5	LSM5	4114	0.052	0.31	YES
42	SFRS3	SFRS3	SFRS3	4172	0.051	0.31	YES
43	SFRS4	SFRS4	SFRS4	4195	0.051	0.32	YES
44	SFRS1	SFRS1	SFRS1	4296	0.049	0.32	YES
45	PRPF38A	PRPF38A	PRPF38A	4317	0.049	0.33	YES
46	PPIL1	PPIL1	PPIL1	4331	0.048	0.34	YES
47	SF3B14	SF3B14	SF3B14	4334	0.048	0.34	YES
48	TRA2B	TRA2B	TRA2B	4528	0.045	0.34	YES
49	RBM17	RBM17	RBM17	4672	0.043	0.34	YES
50	PRPF40B	PRPF40B	PRPF40B	4787	0.041	0.34	YES
51	SNRPG	SNRPG	SNRPG	4789	0.041	0.34	YES
52	DDX5	DDX5	DDX5	4814	0.041	0.35	YES
53	WBP11	WBP11	WBP11	4889	0.04	0.35	YES
54	MAGOH	MAGOH	MAGOH	5014	0.038	0.35	YES
55	DDX23	DDX23	DDX23	5022	0.038	0.36	YES
56	DDX42	DDX42	DDX42	5056	0.037	0.36	YES
57	NAA38	NAA38	NAA38	5189	0.035	0.36	YES
58	RBMX	RBMX	RBMX	5205	0.035	0.36	YES
59	SNRNP40	SNRNP40	SNRNP40	5297	0.033	0.36	YES
60	SFRS9	SFRS9	SFRS9	5486	0.031	0.36	YES
61	U2AF1	U2AF1	U2AF1	5669	0.028	0.35	YES
62	PRPF4	PRPF4	PRPF4	5701	0.027	0.36	YES
63	RBM22	RBM22	RBM22	5808	0.026	0.35	YES
64	TXNL4A	TXNL4A	TXNL4A	5851	0.025	0.36	YES
65	HNRNPM	HNRNPM	HNRNPM	5861	0.025	0.36	YES
66	TRA2A	TRA2A	TRA2A	5945	0.024	0.36	YES
67	ZMAT2	ZMAT2	ZMAT2	5949	0.024	0.36	YES
68	SF3B3	SF3B3	SF3B3	5950	0.024	0.36	YES
69	THOC3	THOC3	THOC3	6002	0.023	0.37	YES
70	PRPF3	PRPF3	PRPF3	6018	0.023	0.37	YES
71	SNRPA	SNRPA	SNRPA	6027	0.023	0.37	YES
72	BAT1	BAT1	BAT1	6107	0.021	0.37	NO
73	SFRS2B	SFRS2B	SFRS2B	6242	0.02	0.37	NO
74	SFRS5	SFRS5	SFRS5	6330	0.018	0.36	NO
75	SNRNP70	SNRNP70	SNRNP70	6397	0.017	0.36	NO
76	PLRG1	PLRG1	PLRG1	6411	0.017	0.36	NO
77	SNRPD3	SNRPD3	SNRPD3	6428	0.017	0.37	NO
78	PRPF8	PRPF8	PRPF8	6486	0.016	0.37	NO
79	ISY1	ISY1	ISY1	6673	0.014	0.36	NO
80	SNRPB	SNRPB	SNRPB	6750	0.013	0.36	NO
81	HSPA8	HSPA8	HSPA8	6809	0.012	0.36	NO
82	USP39	USP39	USP39	6843	0.011	0.36	NO
83	PPIE	PPIE	PPIE	6950	0.0098	0.35	NO
84	SNRPC	SNRPC	SNRPC	6959	0.0096	0.35	NO
85	CCDC12	CCDC12	CCDC12	7024	0.0086	0.35	NO
86	SFRS7	SFRS7	SFRS7	7088	0.0078	0.35	NO
87	PRPF31	PRPF31	PRPF31	7114	0.0074	0.35	NO
88	LSM2	LSM2	LSM2	7205	0.0059	0.34	NO
89	DHX8	DHX8	DHX8	7208	0.0059	0.34	NO
90	SNRPD2	SNRPD2	SNRPD2	7368	0.0038	0.34	NO
91	HSPA2	HSPA2	HSPA2	7601	0.00083	0.32	NO
92	EFTUD2	EFTUD2	EFTUD2	7916	-0.0038	0.31	NO
93	DHX16	DHX16	DHX16	7950	-0.0042	0.3	NO
94	CWC15	CWC15	CWC15	7967	-0.0045	0.3	NO
95	SF3A1	SF3A1	SF3A1	7976	-0.0046	0.3	NO
96	THOC4	THOC4	THOC4	8101	-0.0066	0.3	NO
97	SF3B4	SF3B4	SF3B4	8364	-0.01	0.29	NO
98	HNRNPA1L2	HNRNPA1L2	HNRNPA1L2	8386	-0.011	0.29	NO
99	SF3B2	SF3B2	SF3B2	8411	-0.011	0.29	NO
100	U2AF2	U2AF2	U2AF2	8502	-0.012	0.28	NO
101	LSM4	LSM4	LSM4	8577	-0.014	0.28	NO
102	CHERP	CHERP	CHERP	8756	-0.016	0.28	NO
103	SFRS2	SFRS2	SFRS2	8759	-0.016	0.28	NO
104	SNRNP200	SNRNP200	SNRNP200	8843	-0.018	0.28	NO
105	PRPF19	PRPF19	PRPF19	8941	-0.019	0.27	NO
106	SFRS6	SFRS6	SFRS6	8955	-0.019	0.28	NO
107	PCBP1	PCBP1	PCBP1	9297	-0.024	0.26	NO
108	BUD31	BUD31	BUD31	9319	-0.024	0.26	NO
109	NHP2L1	NHP2L1	NHP2L1	9340	-0.025	0.27	NO
110	EIF4A3	EIF4A3	EIF4A3	9343	-0.025	0.27	NO
111	DHX38	DHX38	DHX38	9507	-0.027	0.26	NO
112	SF3B5	SF3B5	SF3B5	9738	-0.031	0.26	NO
113	PHF5A	PHF5A	PHF5A	10466	-0.043	0.22	NO
114	SF3A2	SF3A2	SF3A2	10527	-0.044	0.23	NO
115	HSPA1A	HSPA1A	HSPA1A	10801	-0.049	0.22	NO
116	SART1	SART1	SART1	11022	-0.053	0.22	NO
117	CTNNBL1	CTNNBL1	CTNNBL1	11842	-0.07	0.18	NO
118	PUF60	PUF60	PUF60	12003	-0.073	0.18	NO
119	XAB2	XAB2	XAB2	12103	-0.075	0.19	NO
120	LSM7	LSM7	LSM7	12398	-0.082	0.19	NO
121	PRPF6	PRPF6	PRPF6	12606	-0.088	0.19	NO
122	PQBP1	PQBP1	PQBP1	12725	-0.091	0.2	NO
123	HSPA6	HSPA6	HSPA6	14519	-0.15	0.12	NO
124	HSPA1B	HSPA1B	HSPA1B	14722	-0.16	0.14	NO
125	HSPA1L	HSPA1L	HSPA1L	17366	-0.33	0.04	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ENO3	ENO3	ENO3	718	0.17	0.016	YES
2	C1D	C1D	C1D	1707	0.11	-0.0039	YES
3	CNOT7	CNOT7	CNOT7	1881	0.1	0.02	YES
4	LSM6	LSM6	LSM6	1998	0.097	0.045	YES
5	EXOSC9	EXOSC9	EXOSC9	2000	0.097	0.077	YES
6	MPHOSPH6	MPHOSPH6	MPHOSPH6	2045	0.095	0.11	YES
7	CNOT6	CNOT6	CNOT6	2144	0.092	0.13	YES
8	ENO2	ENO2	ENO2	2174	0.091	0.16	YES
9	DCP2	DCP2	DCP2	2631	0.079	0.16	YES
10	SKIV2L2	SKIV2L2	SKIV2L2	2738	0.077	0.18	YES
11	CNOT2	CNOT2	CNOT2	2772	0.076	0.2	YES
12	PAPOLA	PAPOLA	PAPOLA	3042	0.071	0.21	YES
13	DCP1A	DCP1A	DCP1A	3099	0.07	0.23	YES
14	CNOT6L	CNOT6L	CNOT6L	3148	0.069	0.25	YES
15	LSM3	LSM3	LSM3	3284	0.066	0.27	YES
16	ZCCHC7	ZCCHC7	ZCCHC7	3787	0.057	0.26	YES
17	LSM1	LSM1	LSM1	3876	0.056	0.27	YES
18	CNOT10	CNOT10	CNOT10	3898	0.055	0.29	YES
19	DDX6	DDX6	DDX6	4075	0.053	0.3	YES
20	LSM5	LSM5	LSM5	4114	0.052	0.31	YES
21	EXOSC10	EXOSC10	EXOSC10	4131	0.052	0.33	YES
22	DIS3	DIS3	DIS3	4272	0.05	0.34	YES
23	PAPOLG	PAPOLG	PAPOLG	4279	0.049	0.35	YES
24	XRN2	XRN2	XRN2	4436	0.047	0.36	YES
25	HSPD1	HSPD1	HSPD1	4522	0.045	0.37	YES
26	ENO1	ENO1	ENO1	4772	0.042	0.37	YES
27	HSPA9	HSPA9	HSPA9	5041	0.037	0.37	YES
28	NAA38	NAA38	NAA38	5189	0.035	0.37	YES
29	XRN1	XRN1	XRN1	5225	0.034	0.38	YES
30	DCP1B	DCP1B	DCP1B	5952	0.024	0.35	NO
31	CNOT1	CNOT1	CNOT1	6054	0.022	0.35	NO
32	CNOT4	CNOT4	CNOT4	6075	0.022	0.36	NO
33	PAPD7	PAPD7	PAPD7	6077	0.022	0.36	NO
34	PNPT1	PNPT1	PNPT1	6197	0.02	0.36	NO
35	PARN	PARN	PARN	6498	0.016	0.35	NO
36	EXOSC2	EXOSC2	EXOSC2	6602	0.015	0.35	NO
37	EXOSC3	EXOSC3	EXOSC3	6695	0.013	0.35	NO
38	PATL1	PATL1	PATL1	6776	0.012	0.35	NO
39	LSM2	LSM2	LSM2	7205	0.0059	0.33	NO
40	RQCD1	RQCD1	RQCD1	7371	0.0038	0.32	NO
41	DCPS	DCPS	DCPS	7400	0.0034	0.32	NO
42	TTC37	TTC37	TTC37	7472	0.0024	0.32	NO
43	CNOT3	CNOT3	CNOT3	7841	-0.0026	0.3	NO
44	EXOSC7	EXOSC7	EXOSC7	7897	-0.0034	0.29	NO
45	EDC3	EDC3	EDC3	8304	-0.0096	0.28	NO
46	LSM4	LSM4	LSM4	8577	-0.014	0.26	NO
47	SKIV2L	SKIV2L	SKIV2L	8893	-0.018	0.25	NO
48	EXOSC8	EXOSC8	EXOSC8	9100	-0.022	0.25	NO
49	WDR61	WDR61	WDR61	9489	-0.027	0.24	NO
50	EXOSC1	EXOSC1	EXOSC1	9759	-0.031	0.23	NO
51	EDC4	EDC4	EDC4	11336	-0.059	0.16	NO
52	LSM7	LSM7	LSM7	12398	-0.082	0.13	NO
53	EXOSC6	EXOSC6	EXOSC6	12684	-0.09	0.15	NO
54	EXOSC4	EXOSC4	EXOSC4	12952	-0.096	0.16	NO
55	EXOSC5	EXOSC5	EXOSC5	13036	-0.099	0.19	NO
56	PAPOLB	PAPOLB	PAPOLB	16737	-0.27	0.075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MNAT1	MNAT1	MNAT1	1657	0.11	-0.027	YES
2	RFC1	RFC1	RFC1	2956	0.073	-0.056	YES
3	GTF2H3	GTF2H3	GTF2H3	3074	0.07	-0.02	YES
4	GTF2H5	GTF2H5	GTF2H5	3124	0.069	0.019	YES
5	POLD3	POLD3	POLD3	3178	0.068	0.057	YES
6	ERCC6	ERCC6	ERCC6	3367	0.065	0.085	YES
7	ERCC4	ERCC4	ERCC4	3584	0.061	0.11	YES
8	RFC4	RFC4	RFC4	3609	0.06	0.14	YES
9	CDK7	CDK7	CDK7	3713	0.058	0.17	YES
10	ERCC8	ERCC8	ERCC8	3734	0.058	0.21	YES
11	RPA2	RPA2	RPA2	3790	0.057	0.24	YES
12	PCNA	PCNA	PCNA	3918	0.055	0.26	YES
13	RFC5	RFC5	RFC5	3968	0.054	0.29	YES
14	RPA1	RPA1	RPA1	4129	0.052	0.32	YES
15	XPA	XPA	XPA	4303	0.049	0.34	YES
16	POLE2	POLE2	POLE2	4443	0.046	0.36	YES
17	DDB2	DDB2	DDB2	4993	0.038	0.35	YES
18	POLE3	POLE3	POLE3	5064	0.037	0.37	YES
19	POLE	POLE	POLE	5222	0.034	0.38	YES
20	ERCC5	ERCC5	ERCC5	5425	0.032	0.39	YES
21	GTF2H4	GTF2H4	GTF2H4	5528	0.03	0.4	YES
22	RFC3	RFC3	RFC3	5770	0.026	0.4	YES
23	LIG1	LIG1	LIG1	5843	0.025	0.41	YES
24	CCNH	CCNH	CCNH	6594	0.015	0.38	NO
25	CUL4B	CUL4B	CUL4B	7117	0.0074	0.36	NO
26	CUL4A	CUL4A	CUL4A	7423	0.0032	0.34	NO
27	GTF2H1	GTF2H1	GTF2H1	7604	0.00079	0.33	NO
28	CETN2	CETN2	CETN2	7807	-0.0022	0.32	NO
29	POLE4	POLE4	POLE4	8012	-0.0053	0.31	NO
30	DDB1	DDB1	DDB1	8021	-0.0055	0.32	NO
31	RBX1	RBX1	RBX1	8218	-0.0082	0.31	NO
32	XPC	XPC	XPC	8378	-0.011	0.31	NO
33	RPA3	RPA3	RPA3	8533	-0.013	0.31	NO
34	RAD23A	RAD23A	RAD23A	8667	-0.015	0.31	NO
35	RFC2	RFC2	RFC2	8692	-0.015	0.32	NO
36	POLD1	POLD1	POLD1	9263	-0.024	0.3	NO
37	POLD2	POLD2	POLD2	9782	-0.032	0.29	NO
38	ERCC3	ERCC3	ERCC3	9842	-0.032	0.3	NO
39	GTF2H2	GTF2H2	GTF2H2	10017	-0.035	0.32	NO
40	ERCC2	ERCC2	ERCC2	10070	-0.036	0.34	NO
41	ERCC1	ERCC1	ERCC1	10313	-0.04	0.34	NO
42	RPA4	RPA4	RPA4	11425	-0.061	0.32	NO
43	POLD4	POLD4	POLD4	12370	-0.082	0.32	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAP2K4	MAP2K4	MAP2K4	1794	0.1	-0.027	YES
2	PARP1	PARP1	PARP1	2021	0.096	0.028	YES
3	CASP3	CASP3	CASP3	2416	0.085	0.065	YES
4	MAP3K1	MAP3K1	MAP3K1	2966	0.072	0.086	YES
5	PAK2	PAK2	PAK2	3352	0.065	0.11	YES
6	RB1	RB1	RB1	3557	0.061	0.14	YES
7	LMNB1	LMNB1	LMNB1	3725	0.058	0.17	YES
8	MAPK8	MAPK8	MAPK8	3880	0.056	0.2	YES
9	BAG4	BAG4	BAG4	3998	0.054	0.24	YES
10	PRKDC	PRKDC	PRKDC	4165	0.051	0.26	YES
11	RIPK1	RIPK1	RIPK1	4266	0.05	0.29	YES
12	CASP8	CASP8	CASP8	4843	0.04	0.29	YES
13	LMNA	LMNA	LMNA	5449	0.031	0.28	YES
14	LMNB2	LMNB2	LMNB2	5598	0.029	0.29	YES
15	SPTAN1	SPTAN1	SPTAN1	5865	0.025	0.29	YES
16	MAP3K7	MAP3K7	MAP3K7	5947	0.024	0.3	YES
17	CASP2	CASP2	CASP2	6126	0.021	0.31	YES
18	DFFA	DFFA	DFFA	7394	0.0035	0.24	NO
19	DFFB	DFFB	DFFB	7735	-0.0013	0.22	NO
20	ARHGDIB	ARHGDIB	ARHGDIB	7739	-0.0013	0.22	NO
21	MADD	MADD	MADD	8191	-0.0078	0.2	NO
22	PAK1	PAK1	PAK1	9096	-0.021	0.17	NO
23	JUN	JUN	JUN	10633	-0.046	0.12	NO
24	TRADD	TRADD	TRADD	11482	-0.062	0.11	NO
25	CRADD	CRADD	CRADD	11492	-0.062	0.16	NO
26	TNFRSF1A	TNFRSF1A	TNFRSF1A	11785	-0.069	0.19	NO
27	FADD	FADD	FADD	12448	-0.084	0.21	NO
28	TNF	TNF	TNF	14469	-0.15	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BLM	BLM	BLM	791	0.16	0.047	YES
2	RAD54B	RAD54B	RAD54B	850	0.16	0.13	YES
3	XRCC2	XRCC2	XRCC2	1036	0.14	0.2	YES
4	BRCA2	BRCA2	BRCA2	1090	0.14	0.28	YES
5	EME1	EME1	EME1	1884	0.1	0.29	YES
6	RAD54L	RAD54L	RAD54L	2191	0.091	0.32	YES
7	POLD3	POLD3	POLD3	3178	0.068	0.31	YES
8	RAD51	RAD51	RAD51	3309	0.066	0.34	YES
9	NBN	NBN	NBN	3376	0.065	0.37	YES
10	RPA2	RPA2	RPA2	3790	0.057	0.38	YES
11	TOP3A	TOP3A	TOP3A	3997	0.054	0.4	YES
12	RPA1	RPA1	RPA1	4129	0.052	0.42	YES
13	RAD50	RAD50	RAD50	5110	0.036	0.39	NO
14	SSBP1	SSBP1	SSBP1	6586	0.015	0.32	NO
15	MRE11A	MRE11A	MRE11A	6667	0.014	0.32	NO
16	SHFM1	SHFM1	SHFM1	6859	0.011	0.31	NO
17	XRCC3	XRCC3	XRCC3	8358	-0.01	0.24	NO
18	RPA3	RPA3	RPA3	8533	-0.013	0.24	NO
19	RAD52	RAD52	RAD52	9037	-0.02	0.22	NO
20	POLD1	POLD1	POLD1	9263	-0.024	0.22	NO
21	POLD2	POLD2	POLD2	9782	-0.032	0.21	NO
22	TOP3B	TOP3B	TOP3B	11387	-0.06	0.15	NO
23	RPA4	RPA4	RPA4	11425	-0.061	0.19	NO
24	RAD51L3	RAD51L3	RAD51L3	11744	-0.068	0.21	NO
25	RAD51L1	RAD51L1	RAD51L1	12199	-0.078	0.23	NO
26	POLD4	POLD4	POLD4	12370	-0.082	0.26	NO
27	MUS81	MUS81	MUS81	12903	-0.095	0.29	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MDM2	MDM2	MDM2	885	0.15	0.0032	YES
2	MAP3K5	MAP3K5	MAP3K5	1509	0.11	0.0077	YES
3	BCL2	BCL2	BCL2	1577	0.11	0.042	YES
4	APAF1	APAF1	APAF1	1651	0.11	0.075	YES
5	PARP1	PARP1	PARP1	2021	0.096	0.088	YES
6	CASP3	CASP3	CASP3	2416	0.085	0.095	YES
7	CASP7	CASP7	CASP7	2964	0.072	0.089	YES
8	MAP3K1	MAP3K1	MAP3K1	2966	0.072	0.11	YES
9	PAK2	PAK2	PAK2	3352	0.065	0.12	YES
10	CYCS	CYCS	CYCS	3447	0.063	0.13	YES
11	RB1	RB1	RB1	3557	0.061	0.15	YES
12	BIRC3	BIRC3	BIRC3	3703	0.059	0.16	YES
13	LMNB1	LMNB1	LMNB1	3725	0.058	0.18	YES
14	MAPK8	MAPK8	MAPK8	3880	0.056	0.19	YES
15	BAG4	BAG4	BAG4	3998	0.054	0.2	YES
16	PRKDC	PRKDC	PRKDC	4165	0.051	0.21	YES
17	RASA1	RASA1	RASA1	4180	0.051	0.22	YES
18	RIPK1	RIPK1	RIPK1	4266	0.05	0.24	YES
19	CHUK	CHUK	CHUK	4553	0.045	0.24	YES
20	CASP8	CASP8	CASP8	4843	0.04	0.23	YES
21	BIRC2	BIRC2	BIRC2	5134	0.036	0.23	YES
22	FAS	FAS	FAS	5194	0.035	0.24	YES
23	LMNA	LMNA	LMNA	5449	0.031	0.24	YES
24	LMNB2	LMNB2	LMNB2	5598	0.029	0.24	YES
25	PSEN1	PSEN1	PSEN1	5698	0.028	0.24	YES
26	SPTAN1	SPTAN1	SPTAN1	5865	0.025	0.24	NO
27	CASP2	CASP2	CASP2	6126	0.021	0.23	NO
28	XIAP	XIAP	XIAP	6582	0.015	0.21	NO
29	CASP6	CASP6	CASP6	7282	0.005	0.18	NO
30	PTK2	PTK2	PTK2	7329	0.0044	0.18	NO
31	DFFA	DFFA	DFFA	7394	0.0035	0.17	NO
32	DAXX	DAXX	DAXX	7440	0.0029	0.17	NO
33	DFFB	DFFB	DFFB	7735	-0.0013	0.16	NO
34	ARHGDIB	ARHGDIB	ARHGDIB	7739	-0.0013	0.16	NO
35	PSEN2	PSEN2	PSEN2	7863	-0.0029	0.15	NO
36	CDK11B	CDK11B	CDK11B	7998	-0.0049	0.14	NO
37	NFKB1	NFKB1	NFKB1	8023	-0.0055	0.14	NO
38	MAP2K7	MAP2K7	MAP2K7	8143	-0.0072	0.14	NO
39	CASP9	CASP9	CASP9	8312	-0.0098	0.14	NO
40	CDK11A	CDK11A	CDK11A	9054	-0.021	0.1	NO
41	ACTG1	ACTG1	ACTG1	9061	-0.021	0.11	NO
42	TRAF2	TRAF2	TRAF2	9544	-0.028	0.09	NO
43	PRKCD	PRKCD	PRKCD	9783	-0.032	0.088	NO
44	GSN	GSN	GSN	9847	-0.032	0.096	NO
45	CFLAR	CFLAR	CFLAR	10761	-0.049	0.062	NO
46	NUMA1	NUMA1	NUMA1	10937	-0.052	0.069	NO
47	TNFRSF1B	TNFRSF1B	TNFRSF1B	10962	-0.052	0.086	NO
48	NFKBIA	NFKBIA	NFKBIA	11359	-0.059	0.084	NO
49	TRADD	TRADD	TRADD	11482	-0.062	0.099	NO
50	CRADD	CRADD	CRADD	11492	-0.062	0.12	NO
51	RELA	RELA	RELA	11667	-0.066	0.13	NO
52	TNFRSF1A	TNFRSF1A	TNFRSF1A	11785	-0.069	0.15	NO
53	FADD	FADD	FADD	12448	-0.084	0.14	NO
54	MAP3K14	MAP3K14	MAP3K14	12756	-0.091	0.16	NO
55	BID	BID	BID	12853	-0.094	0.18	NO
56	TNF	TNF	TNF	14469	-0.15	0.14	NO
57	TRAF1	TRAF1	TRAF1	14847	-0.17	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDC7	CDC7	CDC7	313	0.23	0.014	YES
2	CCNB3	CCNB3	CCNB3	828	0.16	0.0061	YES
3	MDM2	MDM2	MDM2	885	0.15	0.023	YES
4	TTK	TTK	TTK	942	0.15	0.04	YES
5	BUB1B	BUB1B	BUB1B	1126	0.13	0.048	YES
6	CDC25A	CDC25A	CDC25A	1173	0.13	0.063	YES
7	PTTG1	PTTG1	PTTG1	1345	0.12	0.07	YES
8	MAD2L1	MAD2L1	MAD2L1	1553	0.11	0.073	YES
9	CDK1	CDK1	CDK1	1569	0.11	0.087	YES
10	BUB1	BUB1	BUB1	1614	0.11	0.1	YES
11	E2F2	E2F2	E2F2	1678	0.11	0.11	YES
12	SMAD2	SMAD2	SMAD2	1736	0.1	0.12	YES
13	E2F3	E2F3	E2F3	2040	0.096	0.12	YES
14	SKP2	SKP2	SKP2	2042	0.096	0.13	YES
15	SMC1B	SMC1B	SMC1B	2176	0.091	0.14	YES
16	ORC1L	ORC1L	ORC1L	2246	0.09	0.14	YES
17	CDK6	CDK6	CDK6	2549	0.082	0.14	YES
18	CDC20	CDC20	CDC20	2712	0.078	0.14	YES
19	CCNA2	CCNA2	CCNA2	2783	0.076	0.14	YES
20	ANAPC4	ANAPC4	ANAPC4	2977	0.072	0.14	YES
21	CDC25C	CDC25C	CDC25C	2994	0.072	0.15	YES
22	CDC27	CDC27	CDC27	3097	0.07	0.16	YES
23	HDAC2	HDAC2	HDAC2	3180	0.068	0.16	YES
24	CCNB2	CCNB2	CCNB2	3208	0.068	0.17	YES
25	CHEK1	CHEK1	CHEK1	3278	0.066	0.17	YES
26	MCM3	MCM3	MCM3	3311	0.066	0.18	YES
27	ORC2L	ORC2L	ORC2L	3400	0.064	0.18	YES
28	RB1	RB1	RB1	3557	0.061	0.18	YES
29	YWHAE	YWHAE	YWHAE	3586	0.061	0.19	YES
30	CCNE2	CCNE2	CCNE2	3587	0.061	0.2	YES
31	MCM6	MCM6	MCM6	3649	0.06	0.2	YES
32	HDAC1	HDAC1	HDAC1	3677	0.059	0.21	YES
33	CDC6	CDC6	CDC6	3688	0.059	0.22	YES
34	CDK7	CDK7	CDK7	3713	0.058	0.22	YES
35	PTTG2	PTTG2	PTTG2	3715	0.058	0.23	YES
36	CDK2	CDK2	CDK2	3742	0.058	0.24	YES
37	PCNA	PCNA	PCNA	3918	0.055	0.24	YES
38	ESPL1	ESPL1	ESPL1	3975	0.054	0.24	YES
39	CCNB1	CCNB1	CCNB1	4044	0.053	0.24	YES
40	PRKDC	PRKDC	PRKDC	4165	0.051	0.24	YES
41	CDC14B	CDC14B	CDC14B	4398	0.047	0.24	YES
42	GSK3B	GSK3B	GSK3B	4777	0.041	0.22	YES
43	CDC25B	CDC25B	CDC25B	4791	0.041	0.22	YES
44	CDC23	CDC23	CDC23	4896	0.04	0.22	YES
45	TGFB2	TGFB2	TGFB2	4935	0.039	0.23	YES
46	ATM	ATM	ATM	4941	0.039	0.23	YES
47	MCM4	MCM4	MCM4	4975	0.038	0.24	YES
48	SKP1	SKP1	SKP1	5067	0.037	0.24	YES
49	ORC4L	ORC4L	ORC4L	5080	0.036	0.24	YES
50	SMAD4	SMAD4	SMAD4	5239	0.034	0.24	YES
51	ANAPC10	ANAPC10	ANAPC10	5303	0.033	0.24	YES
52	BUB3	BUB3	BUB3	5335	0.033	0.24	YES
53	YWHAZ	YWHAZ	YWHAZ	5373	0.032	0.24	YES
54	CHEK2	CHEK2	CHEK2	5386	0.032	0.25	YES
55	RAD21	RAD21	RAD21	5395	0.032	0.25	YES
56	MAD2L2	MAD2L2	MAD2L2	5512	0.03	0.25	NO
57	CDKN1B	CDKN1B	CDKN1B	5852	0.025	0.23	NO
58	SMC1A	SMC1A	SMC1A	5899	0.025	0.23	NO
59	SFN	SFN	SFN	5919	0.024	0.24	NO
60	STAG1	STAG1	STAG1	6182	0.02	0.22	NO
61	ATR	ATR	ATR	6189	0.02	0.22	NO
62	ANAPC7	ANAPC7	ANAPC7	6351	0.018	0.22	NO
63	CCNH	CCNH	CCNH	6594	0.015	0.21	NO
64	ANAPC13	ANAPC13	ANAPC13	6689	0.013	0.2	NO
65	SMC3	SMC3	SMC3	6798	0.012	0.2	NO
66	YWHAQ	YWHAQ	YWHAQ	6907	0.01	0.2	NO
67	STAG2	STAG2	STAG2	6969	0.0094	0.19	NO
68	CDKN1A	CDKN1A	CDKN1A	6977	0.0092	0.19	NO
69	GADD45A	GADD45A	GADD45A	7063	0.0081	0.19	NO
70	WEE1	WEE1	WEE1	7173	0.0064	0.18	NO
71	CUL1	CUL1	CUL1	7180	0.0062	0.18	NO
72	CCNE1	CCNE1	CCNE1	7237	0.0055	0.18	NO
73	CDC45	CDC45	CDC45	7297	0.0047	0.18	NO
74	TFDP1	TFDP1	TFDP1	7411	0.0033	0.17	NO
75	CDKN2C	CDKN2C	CDKN2C	7609	0.00076	0.16	NO
76	ORC3L	ORC3L	ORC3L	7715	-0.001	0.16	NO
77	EP300	EP300	EP300	7757	-0.0016	0.16	NO
78	CCND2	CCND2	CCND2	7855	-0.0028	0.15	NO
79	YWHAG	YWHAG	YWHAG	7913	-0.0038	0.15	NO
80	ORC6L	ORC6L	ORC6L	7990	-0.0048	0.14	NO
81	E2F5	E2F5	E2F5	8070	-0.0061	0.14	NO
82	ANAPC1	ANAPC1	ANAPC1	8188	-0.0078	0.14	NO
83	RBX1	RBX1	RBX1	8218	-0.0082	0.14	NO
84	RBL2	RBL2	RBL2	8232	-0.0084	0.14	NO
85	ORC5L	ORC5L	ORC5L	8292	-0.0095	0.13	NO
86	CCND1	CCND1	CCND1	8353	-0.01	0.13	NO
87	PLK1	PLK1	PLK1	8436	-0.011	0.13	NO
88	CREBBP	CREBBP	CREBBP	8574	-0.014	0.12	NO
89	YWHAH	YWHAH	YWHAH	8731	-0.016	0.12	NO
90	ANAPC5	ANAPC5	ANAPC5	8790	-0.017	0.12	NO
91	ZBTB17	ZBTB17	ZBTB17	9058	-0.021	0.1	NO
92	CDK4	CDK4	CDK4	9094	-0.021	0.1	NO
93	YWHAB	YWHAB	YWHAB	9214	-0.023	0.1	NO
94	CDC16	CDC16	CDC16	9386	-0.025	0.094	NO
95	PKMYT1	PKMYT1	PKMYT1	9425	-0.026	0.095	NO
96	SMAD3	SMAD3	SMAD3	9571	-0.028	0.091	NO
97	MCM5	MCM5	MCM5	9726	-0.031	0.086	NO
98	MCM7	MCM7	MCM7	9728	-0.031	0.091	NO
99	MCM2	MCM2	MCM2	9743	-0.031	0.094	NO
100	CDC14A	CDC14A	CDC14A	9900	-0.033	0.09	NO
101	ABL1	ABL1	ABL1	10037	-0.035	0.087	NO
102	FZR1	FZR1	FZR1	10232	-0.039	0.081	NO
103	CCND3	CCND3	CCND3	10266	-0.039	0.085	NO
104	TP53	TP53	TP53	10371	-0.041	0.084	NO
105	RBL1	RBL1	RBL1	10492	-0.044	0.084	NO
106	TFDP2	TFDP2	TFDP2	10500	-0.044	0.089	NO
107	ANAPC2	ANAPC2	ANAPC2	10884	-0.051	0.074	NO
108	E2F4	E2F4	E2F4	11087	-0.054	0.07	NO
109	GADD45G	GADD45G	GADD45G	11797	-0.069	0.04	NO
110	CDC26	CDC26	CDC26	12151	-0.077	0.031	NO
111	MAD1L1	MAD1L1	MAD1L1	12310	-0.08	0.033	NO
112	MYC	MYC	MYC	12700	-0.09	0.023	NO
113	E2F1	E2F1	E2F1	13132	-0.1	0.013	NO
114	WEE2	WEE2	WEE2	13218	-0.1	0.022	NO
115	ANAPC11	ANAPC11	ANAPC11	13832	-0.12	0.0045	NO
116	CDKN2D	CDKN2D	CDKN2D	13865	-0.12	0.019	NO
117	CDKN2A	CDKN2A	CDKN2A	14312	-0.14	0.014	NO
118	CDKN2B	CDKN2B	CDKN2B	15112	-0.18	-0.0071	NO
119	GADD45B	GADD45B	GADD45B	15745	-0.21	-0.014	NO
120	CDKN1C	CDKN1C	CDKN1C	15792	-0.21	0.012	NO
121	TGFB1	TGFB1	TGFB1	15884	-0.22	0.036	NO
122	CCNA1	CCNA1	CCNA1	17262	-0.32	0.0014	NO
123	TGFB3	TGFB3	TGFB3	17406	-0.33	0.038	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIK3R1	PIK3R1	PIK3R1	2306	0.088	-0.035	YES
2	CDK6	CDK6	CDK6	2549	0.082	0.038	YES
3	RB1	RB1	RB1	3557	0.061	0.047	YES
4	PIK3CA	PIK3CA	PIK3CA	3723	0.058	0.1	YES
5	CDK2	CDK2	CDK2	3742	0.058	0.16	YES
6	CHUK	CHUK	CHUK	4553	0.045	0.16	YES
7	RHOA	RHOA	RHOA	5829	0.026	0.12	YES
8	CDKN1B	CDKN1B	CDKN1B	5852	0.025	0.14	YES
9	CDKN1A	CDKN1A	CDKN1A	6977	0.0092	0.092	YES
10	CCNE1	CCNE1	CCNE1	7237	0.0055	0.083	YES
11	MAPK1	MAPK1	MAPK1	7351	0.0039	0.081	YES
12	RAC1	RAC1	RAC1	7386	0.0036	0.083	YES
13	TFDP1	TFDP1	TFDP1	7411	0.0033	0.085	YES
14	AKT1	AKT1	AKT1	7778	-0.0018	0.067	YES
15	NFKB1	NFKB1	NFKB1	8023	-0.0055	0.059	YES
16	CCND1	CCND1	CCND1	8353	-0.01	0.052	YES
17	RAF1	RAF1	RAF1	8857	-0.018	0.043	YES
18	CDK4	CDK4	CDK4	9094	-0.021	0.052	YES
19	PAK1	PAK1	PAK1	9096	-0.021	0.075	YES
20	HRAS	HRAS	HRAS	10746	-0.048	0.034	YES
21	IKBKB	IKBKB	IKBKB	11127	-0.055	0.071	YES
22	MAPK3	MAPK3	MAPK3	11323	-0.058	0.12	YES
23	NFKBIA	NFKBIA	NFKBIA	11359	-0.059	0.18	YES
24	RELA	RELA	RELA	11667	-0.066	0.24	YES
25	IKBKG	IKBKG	IKBKG	13519	-0.11	0.25	YES

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA ERK PATHWAY	27	genes.ES.table	0.22	0.75	0.75	1	1	1	0.78	0.22	1	0.88
BIOCARTA DEATH PATHWAY	32	genes.ES.table	0.23	0.9	0.56	1	1	0.031	0.00028	0.031	1	0.71
BIOCARTA RACCYCD PATHWAY	25	genes.ES.table	0.21	0.9	0.59	1	1	1	0.79	0.21	1	0.64
BIOCARTA CHREBP2 PATHWAY	41	genes.ES.table	0.26	1	0.44	1	1	0.098	0.099	0.088	0.99	0.49
BIOCARTA WNT PATHWAY	25	genes.ES.table	0.3	1.1	0.36	0.99	1	0.04	0.00061	0.04	0.9	0.4
KEGG CITRATE CYCLE TCA CYCLE	29	genes.ES.table	0.28	0.89	0.56	1	1	1	0.72	0.28	1	0.57
KEGG CYSTEINE AND METHIONINE METABOLISM	32	genes.ES.table	0.22	0.75	0.85	1	1	0.12	0.073	0.12	1	0.84
KEGG LYSINE DEGRADATION	43	genes.ES.table	0.52	2.1	0.0039	0.021	0.036	0.23	0.14	0.2	0	0.006
KEGG SELENOAMINO ACID METABOLISM	25	genes.ES.table	0.35	1.1	0.32	1	0.99	0.2	0.16	0.17	0.94	0.45
KEGG PROPANOATE METABOLISM	31	genes.ES.table	0.37	1.2	0.25	0.99	0.99	0.58	0.32	0.4	0.85	0.41

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIPOX	PIPOX	PIPOX	1	0.58	0.2	YES
2	AASS	AASS	AASS	201	0.28	0.28	YES
3	BBOX1	BBOX1	BBOX1	510	0.2	0.33	YES
4	SETDB2	SETDB2	SETDB2	868	0.16	0.37	YES
5	PLOD2	PLOD2	PLOD2	894	0.16	0.42	YES
6	AASDHPPT	AASDHPPT	AASDHPPT	1125	0.14	0.46	YES
7	OGDHL	OGDHL	OGDHL	1477	0.12	0.48	YES
8	ACAT1	ACAT1	ACAT1	1908	0.11	0.49	YES
9	WHSC1L1	WHSC1L1	WHSC1L1	2189	0.098	0.51	YES
10	SUV420H1	SUV420H1	SUV420H1	2563	0.087	0.52	YES
11	SETD2	SETD2	SETD2	3211	0.073	0.51	NO
12	ALDH2	ALDH2	ALDH2	3527	0.066	0.51	NO
13	ALDH7A1	ALDH7A1	ALDH7A1	4118	0.055	0.5	NO
14	PLOD3	PLOD3	PLOD3	4561	0.047	0.49	NO
15	ASH1L	ASH1L	ASH1L	5225	0.036	0.47	NO
16	SUV39H2	SUV39H2	SUV39H2	5641	0.03	0.45	NO
17	ALDH3A2	ALDH3A2	ALDH3A2	5652	0.03	0.46	NO
18	ACAT2	ACAT2	ACAT2	5796	0.028	0.46	NO
19	SETMAR	SETMAR	SETMAR	6095	0.023	0.46	NO
20	ALDH9A1	ALDH9A1	ALDH9A1	6177	0.022	0.46	NO
21	GCDH	GCDH	GCDH	6194	0.022	0.46	NO
22	ALDH1B1	ALDH1B1	ALDH1B1	6600	0.016	0.45	NO
23	NSD1	NSD1	NSD1	7191	0.0078	0.42	NO
24	SETD1A	SETD1A	SETD1A	7441	0.004	0.41	NO
25	AASDH	AASDH	AASDH	7638	0.0012	0.4	NO
26	EHMT2	EHMT2	EHMT2	7976	-0.0036	0.38	NO
27	SETD7	SETD7	SETD7	8028	-0.0041	0.38	NO
28	SETD8	SETD8	SETD8	8201	-0.0066	0.37	NO
29	HADHA	HADHA	HADHA	8260	-0.0075	0.37	NO
30	WHSC1	WHSC1	WHSC1	8261	-0.0075	0.37	NO
31	SETD1B	SETD1B	SETD1B	8292	-0.008	0.37	NO
32	SUV39H1	SUV39H1	SUV39H1	8710	-0.014	0.35	NO
33	HADH	HADH	HADH	8826	-0.015	0.35	NO
34	PLOD1	PLOD1	PLOD1	8953	-0.017	0.35	NO
35	TMLHE	TMLHE	TMLHE	9151	-0.02	0.35	NO
36	SETDB1	SETDB1	SETDB1	9178	-0.02	0.35	NO
37	OGDH	OGDH	OGDH	9336	-0.023	0.35	NO
38	ECHS1	ECHS1	ECHS1	9821	-0.03	0.34	NO
39	SUV420H2	SUV420H2	SUV420H2	10311	-0.037	0.32	NO
40	AADAT	AADAT	AADAT	10562	-0.041	0.32	NO
41	DOT1L	DOT1L	DOT1L	12727	-0.086	0.23	NO
42	DLST	DLST	DLST	13020	-0.095	0.25	NO
43	EHMT1	EHMT1	EHMT1	13040	-0.095	0.28	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	C1D	C1D	C1D	485	0.2	0.031	YES
2	NAA38	NAA38	NAA38	614	0.18	0.077	YES
3	MPHOSPH6	MPHOSPH6	MPHOSPH6	1066	0.14	0.094	YES
4	LSM6	LSM6	LSM6	1482	0.12	0.11	YES
5	PNPT1	PNPT1	PNPT1	1525	0.12	0.14	YES
6	DIS3	DIS3	DIS3	1545	0.12	0.17	YES
7	LSM5	LSM5	LSM5	1607	0.12	0.2	YES
8	HSPD1	HSPD1	HSPD1	1761	0.11	0.23	YES
9	EXOSC9	EXOSC9	EXOSC9	2318	0.093	0.22	YES
10	CNOT4	CNOT4	CNOT4	2840	0.08	0.22	YES
11	XRN1	XRN1	XRN1	2875	0.08	0.24	YES
12	CNOT6L	CNOT6L	CNOT6L	3098	0.075	0.25	YES
13	DCP2	DCP2	DCP2	3116	0.075	0.27	YES
14	LSM3	LSM3	LSM3	3117	0.075	0.29	YES
15	DDX6	DDX6	DDX6	3239	0.072	0.3	YES
16	PARN	PARN	PARN	3273	0.072	0.32	YES
17	HSPA9	HSPA9	HSPA9	3275	0.072	0.34	YES
18	EXOSC8	EXOSC8	EXOSC8	3282	0.071	0.36	YES
19	LSM1	LSM1	LSM1	3291	0.071	0.38	YES
20	PAPOLG	PAPOLG	PAPOLG	3788	0.061	0.37	YES
21	SKIV2L2	SKIV2L2	SKIV2L2	3884	0.059	0.39	YES
22	PAPOLA	PAPOLA	PAPOLA	4069	0.056	0.39	YES
23	CNOT6	CNOT6	CNOT6	4377	0.05	0.39	YES
24	ZCCHC7	ZCCHC7	ZCCHC7	4445	0.049	0.4	YES
25	EXOSC5	EXOSC5	EXOSC5	4485	0.048	0.41	YES
26	XRN2	XRN2	XRN2	4951	0.04	0.4	NO
27	PATL1	PATL1	PATL1	5034	0.039	0.4	NO
28	CNOT2	CNOT2	CNOT2	5383	0.033	0.4	NO
29	CNOT7	CNOT7	CNOT7	5833	0.027	0.38	NO
30	CNOT1	CNOT1	CNOT1	6329	0.02	0.36	NO
31	PAPOLB	PAPOLB	PAPOLB	6916	0.012	0.33	NO
32	LSM4	LSM4	LSM4	7118	0.009	0.32	NO
33	EXOSC7	EXOSC7	EXOSC7	7188	0.0079	0.32	NO
34	DCP1A	DCP1A	DCP1A	7358	0.0052	0.31	NO
35	EXOSC1	EXOSC1	EXOSC1	7596	0.0017	0.3	NO
36	CNOT10	CNOT10	CNOT10	7914	-0.0026	0.28	NO
37	TTC37	TTC37	TTC37	7942	-0.003	0.28	NO
38	EXOSC10	EXOSC10	EXOSC10	7988	-0.0036	0.28	NO
39	ENO2	ENO2	ENO2	8060	-0.0044	0.28	NO
40	DCP1B	DCP1B	DCP1B	8105	-0.0052	0.27	NO
41	EXOSC3	EXOSC3	EXOSC3	8688	-0.013	0.25	NO
42	PAPD7	PAPD7	PAPD7	9037	-0.018	0.23	NO
43	SKIV2L	SKIV2L	SKIV2L	9200	-0.021	0.23	NO
44	ENO1	ENO1	ENO1	9542	-0.026	0.22	NO
45	EDC4	EDC4	EDC4	9905	-0.031	0.21	NO
46	EXOSC2	EXOSC2	EXOSC2	10324	-0.038	0.19	NO
47	EDC3	EDC3	EDC3	10466	-0.04	0.2	NO
48	LSM7	LSM7	LSM7	10868	-0.046	0.19	NO
49	WDR61	WDR61	WDR61	10869	-0.046	0.2	NO
50	CNOT3	CNOT3	CNOT3	11008	-0.049	0.21	NO
51	LSM2	LSM2	LSM2	11343	-0.055	0.21	NO
52	DCPS	DCPS	DCPS	11367	-0.056	0.22	NO
53	EXOSC4	EXOSC4	EXOSC4	12616	-0.083	0.18	NO
54	EXOSC6	EXOSC6	EXOSC6	14011	-0.13	0.14	NO
55	ENO3	ENO3	ENO3	14452	-0.15	0.16	NO
56	RQCD1	RQCD1	RQCD1	14715	-0.16	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CTNNBL1	CTNNBL1	CTNNBL1	597	0.18	-0.0074	YES
2	NAA38	NAA38	NAA38	614	0.18	0.017	YES
3	CWC15	CWC15	CWC15	710	0.17	0.036	YES
4	SYF2	SYF2	SYF2	813	0.16	0.052	YES
5	SR140	SR140	SR140	986	0.15	0.064	YES
6	SNRNP27	SNRNP27	SNRNP27	1127	0.14	0.076	YES
7	PRPF6	PRPF6	PRPF6	1151	0.14	0.094	YES
8	MAGOHB	MAGOHB	MAGOHB	1166	0.14	0.11	YES
9	ISY1	ISY1	ISY1	1343	0.13	0.12	YES
10	THOC2	THOC2	THOC2	1452	0.12	0.13	YES
11	LSM6	LSM6	LSM6	1482	0.12	0.15	YES
12	LSM5	LSM5	LSM5	1607	0.12	0.16	YES
13	SNRPA1	SNRPA1	SNRPA1	1724	0.11	0.16	YES
14	CDC40	CDC40	CDC40	1822	0.11	0.17	YES
15	CRNKL1	CRNKL1	CRNKL1	1843	0.11	0.19	YES
16	SNRPE	SNRPE	SNRPE	1949	0.1	0.2	YES
17	SLU7	SLU7	SLU7	2151	0.098	0.2	YES
18	SART1	SART1	SART1	2210	0.097	0.21	YES
19	PRPF40A	PRPF40A	PRPF40A	2331	0.093	0.22	YES
20	SNRPG	SNRPG	SNRPG	2366	0.092	0.23	YES
21	PRPF38B	PRPF38B	PRPF38B	2518	0.088	0.23	YES
22	SNRPB2	SNRPB2	SNRPB2	2583	0.087	0.24	YES
23	SMNDC1	SMNDC1	SMNDC1	2618	0.086	0.25	YES
24	SNRPF	SNRPF	SNRPF	2728	0.083	0.26	YES
25	SF3B14	SF3B14	SF3B14	2731	0.083	0.27	YES
26	ZMAT2	ZMAT2	ZMAT2	3054	0.076	0.26	YES
27	BUD31	BUD31	BUD31	3075	0.075	0.27	YES
28	LSM3	LSM3	LSM3	3117	0.075	0.28	YES
29	DDX46	DDX46	DDX46	3296	0.071	0.28	YES
30	TRA2A	TRA2A	TRA2A	3336	0.07	0.28	YES
31	PRPF40B	PRPF40B	PRPF40B	3561	0.066	0.28	YES
32	SNW1	SNW1	SNW1	3570	0.065	0.29	YES
33	SF3B2	SF3B2	SF3B2	3597	0.064	0.3	YES
34	HNRNPA3	HNRNPA3	HNRNPA3	3889	0.059	0.29	YES
35	PRPF18	PRPF18	PRPF18	3904	0.058	0.3	YES
36	SNRPD3	SNRPD3	SNRPD3	3908	0.058	0.3	YES
37	HNRNPK	HNRNPK	HNRNPK	3911	0.058	0.31	YES
38	SFRS6	SFRS6	SFRS6	4053	0.056	0.31	YES
39	DDX42	DDX42	DDX42	4072	0.056	0.32	YES
40	PQBP1	PQBP1	PQBP1	4100	0.055	0.32	YES
41	SFRS13A	SFRS13A	SFRS13A	4157	0.054	0.33	YES
42	THOC1	THOC1	THOC1	4175	0.054	0.34	YES
43	MAGOH	MAGOH	MAGOH	4262	0.052	0.34	YES
44	HNRNPU	HNRNPU	HNRNPU	4426	0.049	0.34	YES
45	SFRS1	SFRS1	SFRS1	4483	0.048	0.34	YES
46	TCERG1	TCERG1	TCERG1	4526	0.047	0.34	YES
47	PRPF3	PRPF3	PRPF3	4762	0.044	0.34	YES
48	PLRG1	PLRG1	PLRG1	4870	0.042	0.34	YES
49	SNRNP200	SNRNP200	SNRNP200	4911	0.041	0.34	YES
50	RBM25	RBM25	RBM25	4942	0.04	0.34	YES
51	RBM17	RBM17	RBM17	4966	0.04	0.35	YES
52	CDC5L	CDC5L	CDC5L	5016	0.039	0.35	YES
53	SFRS3	SFRS3	SFRS3	5157	0.037	0.35	YES
54	BCAS2	BCAS2	BCAS2	5270	0.035	0.35	YES
55	NHP2L1	NHP2L1	NHP2L1	5475	0.032	0.34	YES
56	SFRS4	SFRS4	SFRS4	5506	0.032	0.34	YES
57	SNRPD2	SNRPD2	SNRPD2	5582	0.03	0.34	YES
58	RBM22	RBM22	RBM22	5658	0.029	0.34	YES
59	PRPF19	PRPF19	PRPF19	5666	0.029	0.35	YES
60	THOC4	THOC4	THOC4	5711	0.029	0.35	YES
61	RBMX	RBMX	RBMX	5743	0.028	0.35	YES
62	USP39	USP39	USP39	5770	0.028	0.35	YES
63	SFRS5	SFRS5	SFRS5	6078	0.023	0.34	NO
64	SFRS2B	SFRS2B	SFRS2B	6211	0.021	0.34	NO
65	CHERP	CHERP	CHERP	6221	0.021	0.34	NO
66	DHX8	DHX8	DHX8	6331	0.02	0.34	NO
67	CCDC12	CCDC12	CCDC12	6349	0.019	0.34	NO
68	SF3A2	SF3A2	SF3A2	6466	0.018	0.33	NO
69	SF3B3	SF3B3	SF3B3	6528	0.017	0.33	NO
70	DDX5	DDX5	DDX5	6529	0.017	0.33	NO
71	SF3A3	SF3A3	SF3A3	6585	0.016	0.33	NO
72	DDX23	DDX23	DDX23	6625	0.016	0.33	NO
73	NCBP1	NCBP1	NCBP1	6715	0.014	0.33	NO
74	PPIH	PPIH	PPIH	6756	0.014	0.33	NO
75	SF3B1	SF3B1	SF3B1	6761	0.014	0.33	NO
76	U2AF1	U2AF1	U2AF1	6970	0.011	0.32	NO
77	RBM8A	RBM8A	RBM8A	7004	0.01	0.32	NO
78	LSM4	LSM4	LSM4	7118	0.009	0.32	NO
79	SFRS9	SFRS9	SFRS9	7203	0.0077	0.31	NO
80	SNRPD1	SNRPD1	SNRPD1	7273	0.0065	0.31	NO
81	ACIN1	ACIN1	ACIN1	7411	0.0045	0.3	NO
82	WBP11	WBP11	WBP11	7437	0.004	0.3	NO
83	SNRPC	SNRPC	SNRPC	7461	0.0037	0.3	NO
84	PRPF38A	PRPF38A	PRPF38A	7483	0.0034	0.3	NO
85	U2AF2	U2AF2	U2AF2	7626	0.0013	0.29	NO
86	PCBP1	PCBP1	PCBP1	7644	0.0011	0.29	NO
87	DHX15	DHX15	DHX15	7735	0.000066	0.29	NO
88	HNRNPC	HNRNPC	HNRNPC	7748	-0.00015	0.29	NO
89	DHX38	DHX38	DHX38	7773	-0.00054	0.28	NO
90	AQR	AQR	AQR	7955	-0.0032	0.28	NO
91	EFTUD2	EFTUD2	EFTUD2	8043	-0.0043	0.27	NO
92	SNRPA	SNRPA	SNRPA	8112	-0.0053	0.27	NO
93	TRA2B	TRA2B	TRA2B	8127	-0.0055	0.27	NO
94	PRPF8	PRPF8	PRPF8	8179	-0.0062	0.27	NO
95	HNRNPM	HNRNPM	HNRNPM	8182	-0.0064	0.27	NO
96	HSPA1A	HSPA1A	HSPA1A	8366	-0.009	0.26	NO
97	PHF5A	PHF5A	PHF5A	8494	-0.011	0.25	NO
98	SFRS7	SFRS7	SFRS7	8509	-0.011	0.25	NO
99	SF3A1	SF3A1	SF3A1	8556	-0.012	0.25	NO
100	SNRNP70	SNRNP70	SNRNP70	8674	-0.013	0.25	NO
101	DHX16	DHX16	DHX16	8746	-0.014	0.24	NO
102	XAB2	XAB2	XAB2	9102	-0.019	0.23	NO
103	BAT1	BAT1	BAT1	9245	-0.021	0.22	NO
104	HNRNPA1	HNRNPA1	HNRNPA1	9288	-0.022	0.22	NO
105	PRPF4	PRPF4	PRPF4	9339	-0.023	0.22	NO
106	PPIE	PPIE	PPIE	9495	-0.025	0.22	NO
107	PRPF31	PRPF31	PRPF31	9701	-0.028	0.21	NO
108	SF3B4	SF3B4	SF3B4	9797	-0.029	0.21	NO
109	SFRS2	SFRS2	SFRS2	10254	-0.036	0.19	NO
110	EIF4A3	EIF4A3	EIF4A3	10307	-0.037	0.19	NO
111	THOC3	THOC3	THOC3	10462	-0.04	0.19	NO
112	HSPA8	HSPA8	HSPA8	10531	-0.041	0.19	NO
113	PUF60	PUF60	PUF60	10567	-0.041	0.2	NO
114	LSM7	LSM7	LSM7	10868	-0.046	0.18	NO
115	LSM2	LSM2	LSM2	11343	-0.055	0.17	NO
116	PPIL1	PPIL1	PPIL1	11458	-0.058	0.17	NO
117	SNRPB	SNRPB	SNRPB	11761	-0.064	0.16	NO
118	SF3B5	SF3B5	SF3B5	12189	-0.074	0.15	NO
119	TXNL4A	TXNL4A	TXNL4A	12225	-0.075	0.16	NO
120	HSPA6	HSPA6	HSPA6	12304	-0.076	0.16	NO
121	SNRNP40	SNRNP40	SNRNP40	12467	-0.08	0.16	NO
122	HNRNPA1L2	HNRNPA1L2	HNRNPA1L2	13234	-0.1	0.14	NO
123	HSPA1B	HSPA1B	HSPA1B	15249	-0.19	0.049	NO
124	HSPA2	HSPA2	HSPA2	16600	-0.3	0.015	NO
125	HSPA1L	HSPA1L	HSPA1L	17692	-0.49	0.022	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIPOX	PIPOX	PIPOX	1	0.58	0.089	YES
2	BAAT	BAAT	BAAT	36	0.41	0.15	YES
3	ACSL6	ACSL6	ACSL6	48	0.39	0.21	YES
4	DDO	DDO	DDO	223	0.27	0.24	YES
5	PECR	PECR	PECR	270	0.25	0.28	YES
6	AMACR	AMACR	AMACR	661	0.18	0.28	YES
7	CROT	CROT	CROT	705	0.17	0.31	YES
8	PEX12	PEX12	PEX12	764	0.17	0.33	YES
9	NUDT12	NUDT12	NUDT12	885	0.16	0.35	YES
10	HAO2	HAO2	HAO2	1398	0.12	0.34	YES
11	PEX1	PEX1	PEX1	1478	0.12	0.35	YES
12	ACSL4	ACSL4	ACSL4	1526	0.12	0.37	YES
13	PRDX5	PRDX5	PRDX5	1795	0.11	0.37	YES
14	PXMP4	PXMP4	PXMP4	1861	0.11	0.38	YES
15	FAR1	FAR1	FAR1	1978	0.1	0.39	YES
16	ACOT8	ACOT8	ACOT8	2181	0.098	0.4	YES
17	PEX3	PEX3	PEX3	2535	0.088	0.39	YES
18	AGXT	AGXT	AGXT	2584	0.087	0.4	YES
19	PHYH	PHYH	PHYH	2757	0.083	0.41	YES
20	ACSL3	ACSL3	ACSL3	3533	0.066	0.37	NO
21	ACSL5	ACSL5	ACSL5	3790	0.061	0.37	NO
22	PEX16	PEX16	PEX16	3947	0.058	0.37	NO
23	PEX13	PEX13	PEX13	4335	0.051	0.36	NO
24	AGPS	AGPS	AGPS	4502	0.048	0.35	NO
25	SCP2	SCP2	SCP2	4536	0.047	0.36	NO
26	ACOX1	ACOX1	ACOX1	4789	0.043	0.35	NO
27	HSD17B4	HSD17B4	HSD17B4	4994	0.04	0.35	NO
28	SLC25A17	SLC25A17	SLC25A17	5011	0.039	0.35	NO
29	NUDT19	NUDT19	NUDT19	5056	0.038	0.36	NO
30	EHHADH	EHHADH	EHHADH	5101	0.038	0.36	NO
31	GSTK1	GSTK1	GSTK1	5121	0.038	0.36	NO
32	SOD1	SOD1	SOD1	5391	0.033	0.35	NO
33	PEX5	PEX5	PEX5	5537	0.031	0.35	NO
34	PEX7	PEX7	PEX7	5639	0.03	0.35	NO
35	HACL1	HACL1	HACL1	5981	0.025	0.33	NO
36	PRDX1	PRDX1	PRDX1	6198	0.022	0.33	NO
37	FAR2	FAR2	FAR2	6283	0.02	0.32	NO
38	PEX2	PEX2	PEX2	6342	0.019	0.32	NO
39	IDH1	IDH1	IDH1	6599	0.016	0.31	NO
40	ACSL1	ACSL1	ACSL1	6790	0.013	0.3	NO
41	EPHX2	EPHX2	EPHX2	6844	0.013	0.3	NO
42	GNPAT	GNPAT	GNPAT	6845	0.013	0.3	NO
43	CAT	CAT	CAT	7129	0.0088	0.29	NO
44	PEX11B	PEX11B	PEX11B	7576	0.0019	0.27	NO
45	ACOX3	ACOX3	ACOX3	7680	0.00073	0.26	NO
46	PMVK	PMVK	PMVK	7689	0.00068	0.26	NO
47	PEX11A	PEX11A	PEX11A	8040	-0.0043	0.24	NO
48	MPV17	MPV17	MPV17	8157	-0.006	0.24	NO
49	ABCD3	ABCD3	ABCD3	8404	-0.0095	0.22	NO
50	SOD2	SOD2	SOD2	8419	-0.0097	0.22	NO
51	IDH2	IDH2	IDH2	8736	-0.014	0.21	NO
52	PEX10	PEX10	PEX10	9014	-0.018	0.2	NO
53	PEX19	PEX19	PEX19	9235	-0.021	0.19	NO
54	MLYCD	MLYCD	MLYCD	9338	-0.023	0.18	NO
55	DHRS4	DHRS4	DHRS4	9361	-0.023	0.19	NO
56	PEX14	PEX14	PEX14	9434	-0.024	0.19	NO
57	DECR2	DECR2	DECR2	9444	-0.024	0.19	NO
58	MPV17L	MPV17L	MPV17L	9545	-0.026	0.19	NO
59	ABCD1	ABCD1	ABCD1	9620	-0.026	0.19	NO
60	PAOX	PAOX	PAOX	9838	-0.03	0.18	NO
61	SLC27A2	SLC27A2	SLC27A2	10013	-0.032	0.18	NO
62	HMGCL	HMGCL	HMGCL	10121	-0.034	0.18	NO
63	ECH1	ECH1	ECH1	10273	-0.037	0.17	NO
64	MVK	MVK	MVK	10930	-0.048	0.14	NO
65	ACAA1	ACAA1	ACAA1	11355	-0.056	0.13	NO
66	PEX6	PEX6	PEX6	11453	-0.057	0.13	NO
67	PEX26	PEX26	PEX26	11651	-0.062	0.13	NO
68	CRAT	CRAT	CRAT	12291	-0.076	0.11	NO
69	PEX11G	PEX11G	PEX11G	12910	-0.091	0.088	NO
70	ABCD4	ABCD4	ABCD4	12920	-0.092	0.1	NO
71	PXMP2	PXMP2	PXMP2	13068	-0.096	0.11	NO
72	PECI	PECI	PECI	13885	-0.12	0.082	NO
73	XDH	XDH	XDH	15259	-0.19	0.036	NO
74	ABCD2	ABCD2	ABCD2	16029	-0.24	0.03	NO
75	DAO	DAO	DAO	16095	-0.25	0.065	NO
76	NOS2	NOS2	NOS2	16591	-0.29	0.083	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPA4	RPA4	RPA4	385	0.22	0.082	YES
2	SHFM1	SHFM1	SHFM1	567	0.19	0.16	YES
3	MRE11A	MRE11A	MRE11A	921	0.15	0.22	YES
4	BRCA2	BRCA2	BRCA2	1228	0.13	0.26	YES
5	XRCC2	XRCC2	XRCC2	1263	0.13	0.33	YES
6	RPA3	RPA3	RPA3	2070	0.1	0.33	YES
7	RAD50	RAD50	RAD50	2104	0.1	0.38	YES
8	SSBP1	SSBP1	SSBP1	2157	0.098	0.42	YES
9	NBN	NBN	NBN	2726	0.083	0.43	YES
10	BLM	BLM	BLM	3342	0.07	0.43	NO
11	RAD54B	RAD54B	RAD54B	4625	0.046	0.38	NO
12	RAD51L3	RAD51L3	RAD51L3	5923	0.025	0.32	NO
13	EME1	EME1	EME1	7646	0.0011	0.22	NO
14	POLD4	POLD4	POLD4	7658	0.00096	0.22	NO
15	POLD2	POLD2	POLD2	8026	-0.0041	0.21	NO
16	RPA1	RPA1	RPA1	8571	-0.012	0.18	NO
17	POLD3	POLD3	POLD3	8759	-0.014	0.18	NO
18	RPA2	RPA2	RPA2	9337	-0.023	0.16	NO
19	RAD51L1	RAD51L1	RAD51L1	10504	-0.04	0.11	NO
20	RAD52	RAD52	RAD52	10509	-0.041	0.13	NO
21	MUS81	MUS81	MUS81	10553	-0.041	0.15	NO
22	RAD54L	RAD54L	RAD54L	10851	-0.046	0.15	NO
23	TOP3A	TOP3A	TOP3A	11342	-0.055	0.15	NO
24	RAD51	RAD51	RAD51	12657	-0.084	0.12	NO
25	TOP3B	TOP3B	TOP3B	12700	-0.086	0.16	NO
26	POLD1	POLD1	POLD1	13298	-0.1	0.18	NO
27	XRCC3	XRCC3	XRCC3	15174	-0.18	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPA4	RPA4	RPA4	385	0.22	0.062	YES
2	ERCC5	ERCC5	ERCC5	1726	0.11	0.031	YES
3	CETN2	CETN2	CETN2	1790	0.11	0.07	YES
4	CDK7	CDK7	CDK7	1819	0.11	0.11	YES
5	CUL4B	CUL4B	CUL4B	1852	0.11	0.15	YES
6	RFC3	RFC3	RFC3	1911	0.11	0.19	YES
7	GTF2H5	GTF2H5	GTF2H5	2068	0.1	0.22	YES
8	RPA3	RPA3	RPA3	2070	0.1	0.26	YES
9	RFC1	RFC1	RFC1	2976	0.078	0.24	YES
10	CUL4A	CUL4A	CUL4A	3099	0.075	0.26	YES
11	XPA	XPA	XPA	3163	0.074	0.28	YES
12	CCNH	CCNH	CCNH	3247	0.072	0.31	YES
13	XPC	XPC	XPC	3658	0.063	0.31	YES
14	GTF2H1	GTF2H1	GTF2H1	4058	0.056	0.31	YES
15	RFC4	RFC4	RFC4	4167	0.054	0.32	YES
16	RFC5	RFC5	RFC5	4909	0.041	0.3	NO
17	RAD23A	RAD23A	RAD23A	5032	0.039	0.31	NO
18	ERCC6	ERCC6	ERCC6	5320	0.034	0.3	NO
19	RFC2	RFC2	RFC2	5350	0.034	0.32	NO
20	MNAT1	MNAT1	MNAT1	6048	0.024	0.29	NO
21	ERCC4	ERCC4	ERCC4	6067	0.024	0.29	NO
22	DDB1	DDB1	DDB1	6713	0.014	0.26	NO
23	RBX1	RBX1	RBX1	6759	0.014	0.27	NO
24	ERCC3	ERCC3	ERCC3	7226	0.0073	0.24	NO
25	POLE4	POLE4	POLE4	7384	0.0049	0.24	NO
26	POLD4	POLD4	POLD4	7658	0.00096	0.22	NO
27	POLE	POLE	POLE	7887	-0.0022	0.21	NO
28	POLD2	POLD2	POLD2	8026	-0.0041	0.2	NO
29	LIG1	LIG1	LIG1	8101	-0.0052	0.2	NO
30	RPA1	RPA1	RPA1	8571	-0.012	0.18	NO
31	POLD3	POLD3	POLD3	8759	-0.014	0.18	NO
32	ERCC8	ERCC8	ERCC8	9062	-0.018	0.17	NO
33	RPA2	RPA2	RPA2	9337	-0.023	0.16	NO
34	POLE3	POLE3	POLE3	9415	-0.024	0.16	NO
35	GTF2H3	GTF2H3	GTF2H3	9965	-0.032	0.15	NO
36	ERCC1	ERCC1	ERCC1	10721	-0.044	0.12	NO
37	POLE2	POLE2	POLE2	11263	-0.054	0.11	NO
38	GTF2H4	GTF2H4	GTF2H4	11884	-0.067	0.1	NO
39	PCNA	PCNA	PCNA	12206	-0.074	0.12	NO
40	DDB2	DDB2	DDB2	12908	-0.091	0.11	NO
41	ERCC2	ERCC2	ERCC2	13267	-0.1	0.13	NO
42	POLD1	POLD1	POLD1	13298	-0.1	0.17	NO
43	GTF2H2	GTF2H2	GTF2H2	16099	-0.25	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ABAT	ABAT	ABAT	64	0.36	0.19	YES
2	ACAT1	ACAT1	ACAT1	1908	0.11	0.14	YES
3	ACSS1	ACSS1	ACSS1	1962	0.1	0.2	YES
4	SUCLA2	SUCLA2	SUCLA2	2971	0.078	0.18	YES
5	HIBCH	HIBCH	HIBCH	3167	0.074	0.21	YES
6	ACSS2	ACSS2	ACSS2	3518	0.066	0.22	YES
7	ALDH2	ALDH2	ALDH2	3527	0.066	0.26	YES
8	ACACB	ACACB	ACACB	4040	0.056	0.26	YES
9	MCEE	MCEE	MCEE	4065	0.056	0.29	YES
10	ALDH7A1	ALDH7A1	ALDH7A1	4118	0.055	0.32	YES
11	LDHB	LDHB	LDHB	4575	0.047	0.32	YES
12	SUCLG2	SUCLG2	SUCLG2	5076	0.038	0.31	YES
13	EHHADH	EHHADH	EHHADH	5101	0.038	0.33	YES
14	SUCLG1	SUCLG1	SUCLG1	5262	0.036	0.34	YES
15	LDHA	LDHA	LDHA	5392	0.033	0.35	YES
16	ACADM	ACADM	ACADM	5574	0.031	0.35	YES
17	ALDH3A2	ALDH3A2	ALDH3A2	5652	0.03	0.36	YES
18	ACAT2	ACAT2	ACAT2	5796	0.028	0.37	YES
19	ALDH9A1	ALDH9A1	ALDH9A1	6177	0.022	0.36	NO
20	MUT	MUT	MUT	6376	0.019	0.36	NO
21	ALDH1B1	ALDH1B1	ALDH1B1	6600	0.016	0.36	NO
22	LDHAL6A	LDHAL6A	LDHAL6A	6743	0.014	0.36	NO
23	ACACA	ACACA	ACACA	8100	-0.0052	0.28	NO
24	HADHA	HADHA	HADHA	8260	-0.0075	0.28	NO
25	MLYCD	MLYCD	MLYCD	9338	-0.023	0.23	NO
26	PCCA	PCCA	PCCA	9384	-0.023	0.24	NO
27	ECHS1	ECHS1	ECHS1	9821	-0.03	0.23	NO
28	PCCB	PCCB	PCCB	10588	-0.042	0.21	NO
29	ACSS3	ACSS3	ACSS3	13685	-0.12	0.1	NO
30	ALDH6A1	ALDH6A1	ALDH6A1	13706	-0.12	0.16	NO
31	LDHAL6B	LDHAL6B	LDHAL6B	14422	-0.15	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MAT1A	MAT1A	MAT1A	160	0.29	0.18	YES
2	GGT7	GGT7	GGT7	456	0.2	0.29	YES
3	TRMT11	TRMT11	TRMT11	1412	0.12	0.32	YES
4	WBSCR22	WBSCR22	WBSCR22	2416	0.091	0.32	YES
5	METTL6	METTL6	METTL6	2795	0.082	0.35	YES
6	AHCY	AHCY	AHCY	3710	0.062	0.34	NO
7	PAPSS1	PAPSS1	PAPSS1	5195	0.037	0.28	NO
8	LCMT1	LCMT1	LCMT1	5670	0.029	0.28	NO
9	SEPHS1	SEPHS1	SEPHS1	6504	0.018	0.24	NO
10	MAT2B	MAT2B	MAT2B	6517	0.017	0.25	NO
11	HEMK1	HEMK1	HEMK1	6597	0.016	0.26	NO
12	MARS2	MARS2	MARS2	7194	0.0078	0.23	NO
13	METTL2B	METTL2B	METTL2B	8299	-0.0081	0.17	NO
14	GGT1	GGT1	GGT1	8539	-0.011	0.17	NO
15	MARS	MARS	MARS	8643	-0.013	0.17	NO
16	AHCYL1	AHCYL1	AHCYL1	9192	-0.02	0.15	NO
17	CTH	CTH	CTH	9711	-0.028	0.14	NO
18	LCMT2	LCMT2	LCMT2	9825	-0.03	0.16	NO
19	MAT2A	MAT2A	MAT2A	9958	-0.031	0.17	NO
20	GGT5	GGT5	GGT5	9960	-0.032	0.19	NO
21	SCLY	SCLY	SCLY	10157	-0.034	0.2	NO
22	CBS	CBS	CBS	10902	-0.047	0.19	NO
23	GGT6	GGT6	GGT6	11824	-0.066	0.18	NO
24	AHCYL2	AHCYL2	AHCYL2	12818	-0.089	0.18	NO
25	PAPSS2	PAPSS2	PAPSS2	14948	-0.17	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FBXO2	FBXO2	FBXO2	123	0.31	0.031	YES
2	NEDD4	NEDD4	NEDD4	676	0.17	0.021	YES
3	AIRE	AIRE	AIRE	1021	0.15	0.02	YES
4	CUL5	CUL5	CUL5	1211	0.14	0.026	YES
5	UBE2C	UBE2C	UBE2C	1348	0.13	0.034	YES
6	ITCH	ITCH	ITCH	1436	0.12	0.044	YES
7	UBE2B	UBE2B	UBE2B	1551	0.12	0.052	YES
8	HERC3	HERC3	HERC3	1622	0.12	0.062	YES
9	CUL4B	CUL4B	CUL4B	1852	0.11	0.062	YES
10	ANAPC10	ANAPC10	ANAPC10	1921	0.11	0.071	YES
11	ANAPC13	ANAPC13	ANAPC13	2019	0.1	0.078	YES
12	TCEB1	TCEB1	TCEB1	2185	0.098	0.08	YES
13	UBE2W	UBE2W	UBE2W	2272	0.095	0.087	YES
14	FANCL	FANCL	FANCL	2349	0.092	0.094	YES
15	FBXW7	FBXW7	FBXW7	2381	0.092	0.1	YES
16	MID1	MID1	MID1	2443	0.09	0.11	YES
17	UBE4A	UBE4A	UBE4A	2479	0.089	0.12	YES
18	XIAP	XIAP	XIAP	2489	0.089	0.13	YES
19	CBL	CBL	CBL	2643	0.085	0.13	YES
20	BRCA1	BRCA1	BRCA1	2648	0.085	0.14	YES
21	PARK2	PARK2	PARK2	2676	0.084	0.15	YES
22	WWP1	WWP1	WWP1	2724	0.083	0.16	YES
23	CUL1	CUL1	CUL1	2885	0.079	0.16	YES
24	UBE2H	UBE2H	UBE2H	3053	0.076	0.16	YES
25	CUL4A	CUL4A	CUL4A	3099	0.075	0.16	YES
26	CDC16	CDC16	CDC16	3248	0.072	0.16	YES
27	UBA6	UBA6	UBA6	3260	0.072	0.17	YES
28	UBA2	UBA2	UBA2	3680	0.063	0.16	YES
29	SYVN1	SYVN1	SYVN1	3690	0.063	0.16	YES
30	SIAH1	SIAH1	SIAH1	3866	0.059	0.16	YES
31	UBE2N	UBE2N	UBE2N	3901	0.058	0.17	YES
32	UBE2D1	UBE2D1	UBE2D1	3962	0.058	0.17	YES
33	ANAPC4	ANAPC4	ANAPC4	4135	0.054	0.17	YES
34	FBXO4	FBXO4	FBXO4	4139	0.054	0.17	YES
35	HERC4	HERC4	HERC4	4142	0.054	0.18	YES
36	RNF7	RNF7	RNF7	4186	0.054	0.18	YES
37	UBE2K	UBE2K	UBE2K	4371	0.05	0.18	YES
38	UBE3A	UBE3A	UBE3A	4396	0.05	0.18	YES
39	CDC27	CDC27	CDC27	4466	0.048	0.19	YES
40	BIRC2	BIRC2	BIRC2	4555	0.047	0.19	YES
41	CUL3	CUL3	CUL3	4570	0.047	0.19	YES
42	RHOBTB2	RHOBTB2	RHOBTB2	4620	0.046	0.2	YES
43	MAP3K1	MAP3K1	MAP3K1	4811	0.043	0.19	YES
44	HUWE1	HUWE1	HUWE1	4975	0.04	0.19	YES
45	UBE2D4	UBE2D4	UBE2D4	4976	0.04	0.19	YES
46	CDC23	CDC23	CDC23	5027	0.039	0.19	YES
47	UBR5	UBR5	UBR5	5063	0.038	0.2	YES
48	UBE2E3	UBE2E3	UBE2E3	5179	0.037	0.19	YES
49	SMURF2	SMURF2	SMURF2	5200	0.036	0.2	YES
50	BIRC6	BIRC6	BIRC6	5307	0.035	0.2	YES
51	DET1	DET1	DET1	5345	0.034	0.2	YES
52	TRIM37	TRIM37	TRIM37	5456	0.032	0.2	YES
53	UBE2A	UBE2A	UBE2A	5469	0.032	0.2	YES
54	PRPF19	PRPF19	PRPF19	5666	0.029	0.19	NO
55	SKP1	SKP1	SKP1	5863	0.026	0.18	NO
56	SMURF1	SMURF1	SMURF1	5878	0.026	0.18	NO
57	UBA3	UBA3	UBA3	6172	0.022	0.17	NO
58	UBE2E1	UBE2E1	UBE2E1	6174	0.022	0.17	NO
59	UBE2O	UBE2O	UBE2O	6287	0.02	0.17	NO
60	UBE2Q1	UBE2Q1	UBE2Q1	6350	0.019	0.17	NO
61	UBE2I	UBE2I	UBE2I	6386	0.019	0.17	NO
62	UBE4B	UBE4B	UBE4B	6402	0.019	0.17	NO
63	UBE3C	UBE3C	UBE3C	6445	0.018	0.17	NO
64	DDB1	DDB1	DDB1	6713	0.014	0.16	NO
65	RBX1	RBX1	RBX1	6759	0.014	0.16	NO
66	UBE2M	UBE2M	UBE2M	6887	0.012	0.15	NO
67	UBE2G2	UBE2G2	UBE2G2	6895	0.012	0.15	NO
68	UBE2G1	UBE2G1	UBE2G1	6917	0.012	0.15	NO
69	ANAPC7	ANAPC7	ANAPC7	7046	0.01	0.15	NO
70	CUL2	CUL2	CUL2	7119	0.009	0.14	NO
71	UBA1	UBA1	UBA1	7144	0.0086	0.14	NO
72	FBXW11	FBXW11	FBXW11	7260	0.0067	0.14	NO
73	UBE2D3	UBE2D3	UBE2D3	7275	0.0064	0.14	NO
74	UBE2J1	UBE2J1	UBE2J1	7381	0.0049	0.13	NO
75	UBE2D2	UBE2D2	UBE2D2	7464	0.0036	0.13	NO
76	MDM2	MDM2	MDM2	7546	0.0024	0.12	NO
77	TRIP12	TRIP12	TRIP12	7561	0.0021	0.12	NO
78	FBXW8	FBXW8	FBXW8	7585	0.0018	0.12	NO
79	UBE3B	UBE3B	UBE3B	7691	0.00066	0.12	NO
80	UBE2L3	UBE2L3	UBE2L3	7754	-0.00025	0.11	NO
81	RFWD2	RFWD2	RFWD2	7876	-0.0021	0.11	NO
82	UBE2F	UBE2F	UBE2F	8116	-0.0053	0.094	NO
83	CDC34	CDC34	CDC34	8165	-0.0061	0.092	NO
84	PPIL2	PPIL2	PPIL2	8170	-0.0061	0.093	NO
85	HERC2	HERC2	HERC2	8526	-0.011	0.074	NO
86	UBE2Z	UBE2Z	UBE2Z	8750	-0.014	0.064	NO
87	SAE1	SAE1	SAE1	8766	-0.014	0.065	NO
88	UBE2R2	UBE2R2	UBE2R2	8866	-0.016	0.061	NO
89	TCEB2	TCEB2	TCEB2	8899	-0.016	0.061	NO
90	TRAF6	TRAF6	TRAF6	9022	-0.018	0.057	NO
91	FZR1	FZR1	FZR1	9027	-0.018	0.058	NO
92	ERCC8	ERCC8	ERCC8	9062	-0.018	0.059	NO
93	KLHL9	KLHL9	KLHL9	9219	-0.021	0.053	NO
94	NEDD4L	NEDD4L	NEDD4L	9373	-0.023	0.047	NO
95	ANAPC5	ANAPC5	ANAPC5	9518	-0.025	0.042	NO
96	RCHY1	RCHY1	RCHY1	9605	-0.026	0.04	NO
97	UBE2Q2	UBE2Q2	UBE2Q2	9615	-0.026	0.043	NO
98	ANAPC1	ANAPC1	ANAPC1	9618	-0.026	0.046	NO
99	UBE2E2	UBE2E2	UBE2E2	9654	-0.027	0.047	NO
100	CUL7	CUL7	CUL7	9699	-0.028	0.048	NO
101	CBLB	CBLB	CBLB	9761	-0.029	0.048	NO
102	HERC1	HERC1	HERC1	9796	-0.029	0.05	NO
103	WWP2	WWP2	WWP2	9946	-0.031	0.046	NO
104	BIRC3	BIRC3	BIRC3	10054	-0.033	0.044	NO
105	KEAP1	KEAP1	KEAP1	10109	-0.034	0.045	NO
106	ANAPC11	ANAPC11	ANAPC11	11171	-0.052	-0.0082	NO
107	VHL	VHL	VHL	11328	-0.055	-0.01	NO
108	MGRN1	MGRN1	MGRN1	11463	-0.058	-0.011	NO
109	UBE2QL1	UBE2QL1	UBE2QL1	11535	-0.059	-0.0076	NO
110	SKP2	SKP2	SKP2	11641	-0.062	-0.0059	NO
111	STUB1	STUB1	STUB1	11808	-0.065	-0.0073	NO
112	UBE2J2	UBE2J2	UBE2J2	12335	-0.077	-0.027	NO
113	UBA7	UBA7	UBA7	12360	-0.078	-0.019	NO
114	UBE2L6	UBE2L6	UBE2L6	12528	-0.081	-0.019	NO
115	SOCS3	SOCS3	SOCS3	12538	-0.082	-0.0094	NO
116	UBOX5	UBOX5	UBOX5	12606	-0.083	-0.0031	NO
117	PIAS1	PIAS1	PIAS1	12838	-0.089	-0.0052	NO
118	DDB2	DDB2	DDB2	12908	-0.091	0.002	NO
119	TRIM32	TRIM32	TRIM32	12997	-0.094	0.0084	NO
120	PIAS3	PIAS3	PIAS3	13221	-0.1	0.0082	NO
121	NHLRC1	NHLRC1	NHLRC1	13330	-0.1	0.015	NO
122	PIAS4	PIAS4	PIAS4	13366	-0.1	0.026	NO
123	ANAPC2	ANAPC2	ANAPC2	13455	-0.11	0.034	NO
124	PML	PML	PML	13465	-0.11	0.046	NO
125	CDC20	CDC20	CDC20	13589	-0.11	0.053	NO
126	CBLC	CBLC	CBLC	13630	-0.12	0.065	NO
127	CDC26	CDC26	CDC26	14554	-0.15	0.032	NO
128	PIAS2	PIAS2	PIAS2	14871	-0.17	0.035	NO
129	UBE2S	UBE2S	UBE2S	15332	-0.19	0.032	NO
130	KLHL13	KLHL13	KLHL13	16116	-0.25	0.019	NO
131	UBE2NL	UBE2NL	UBE2NL	17205	-0.37	0.0029	NO
132	SOCS1	SOCS1	SOCS1	17284	-0.38	0.045	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	WIF1	WIF1	WIF1	11	0.48	0.3	YES
2	LEF1	LEF1	LEF1	1653	0.12	0.29	NO
3	GSK3B	GSK3B	GSK3B	4170	0.054	0.18	NO
4	NLK	NLK	NLK	4176	0.054	0.22	NO
5	CCND1	CCND1	CCND1	4328	0.051	0.24	NO
6	APC	APC	APC	4954	0.04	0.23	NO
7	AXIN1	AXIN1	AXIN1	5212	0.036	0.24	NO
8	TAB1	TAB1	TAB1	5370	0.034	0.25	NO
9	MYC	MYC	MYC	5754	0.028	0.25	NO
10	MAP3K7	MAP3K7	MAP3K7	5821	0.027	0.26	NO
11	CSNK1A1	CSNK1A1	CSNK1A1	6303	0.02	0.25	NO
12	HDAC1	HDAC1	HDAC1	6920	0.012	0.22	NO
13	BTRC	BTRC	BTRC	7217	0.0074	0.21	NO
14	CSNK1D	CSNK1D	CSNK1D	7581	0.0019	0.19	NO
15	CREBBP	CREBBP	CREBBP	7643	0.0011	0.19	NO
16	CTNNB1	CTNNB1	CTNNB1	8263	-0.0075	0.16	NO
17	CTBP1	CTBP1	CTBP1	8505	-0.011	0.15	NO
18	PPP2CA	PPP2CA	PPP2CA	8583	-0.012	0.16	NO
19	SMAD4	SMAD4	SMAD4	8684	-0.013	0.16	NO
20	CSNK2A1	CSNK2A1	CSNK2A1	10106	-0.034	0.1	NO
21	FRAT1	FRAT1	FRAT1	10429	-0.039	0.11	NO
22	DVL1	DVL1	DVL1	11957	-0.069	0.066	NO
23	FZD1	FZD1	FZD1	12783	-0.088	0.076	NO
24	TLE1	TLE1	TLE1	14483	-0.15	0.076	NO
25	WNT1	WNT1	WNT1	15346	-0.19	0.15	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus5 enriched pathways

Table 7. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus5. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA FMLP PATHWAY	34	genes.ES.table	0.41	1.4	0.15	1	0.97	0.088	0.084	0.081	1	0.69
KEGG GLYCOLYSIS GLUCONEOGENESIS	58	genes.ES.table	0.37	1.2	0.22	1	0.99	0.31	0.26	0.23	1	0.69
KEGG PENTOSE PHOSPHATE PATHWAY	26	genes.ES.table	0.47	1.4	0.11	1	0.95	0.58	0.37	0.37	1	0.76
KEGG FRUCTOSE AND MANNOSE METABOLISM	33	genes.ES.table	0.35	1.2	0.21	1	0.99	0.58	0.3	0.4	1	0.61
KEGG OXIDATIVE PHOSPHORYLATION	112	genes.ES.table	0.32	1.1	0.39	1	1	0.4	0.31	0.28	1	0.74
KEGG PYRIMIDINE METABOLISM	96	genes.ES.table	0.28	1.3	0.21	1	0.99	0.42	0.31	0.29	1	0.74
KEGG ARGININE AND PROLINE METABOLISM	52	genes.ES.table	0.36	1.2	0.17	1	0.99	0.35	0.26	0.26	1	0.68
KEGG TYROSINE METABOLISM	39	genes.ES.table	0.39	1.1	0.33	1	1	0.46	0.28	0.33	1	0.73
KEGG GLUTATHIONE METABOLISM	45	genes.ES.table	0.38	1.3	0.2	1	0.99	0.38	0.27	0.28	1	0.7
KEGG GLYCEROPHOSPHOLIPID METABOLISM	71	genes.ES.table	0.31	1.2	0.17	1	0.99	0.3	0.22	0.23	1	0.56

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TUBB4Q	TUBB4Q	TUBB4Q	22	1.6	0.16	YES
2	TUBB8	TUBB8	TUBB8	46	1.4	0.3	YES
3	TUBA3D	TUBA3D	TUBA3D	337	0.71	0.35	YES
4	TUBA1A	TUBA1A	TUBA1A	599	0.49	0.39	YES
5	TUBB2A	TUBB2A	TUBB2A	601	0.49	0.44	YES
6	TUBB3	TUBB3	TUBB3	1143	0.32	0.44	YES
7	TUBA8	TUBA8	TUBA8	1875	0.23	0.43	YES
8	TUBAL3	TUBAL3	TUBAL3	1970	0.22	0.44	YES
9	TUBA1C	TUBA1C	TUBA1C	3041	0.16	0.4	NO
10	TUBA3E	TUBA3E	TUBA3E	3395	0.15	0.4	NO
11	CD14	CD14	CD14	3878	0.13	0.38	NO
12	TUBB6	TUBB6	TUBB6	3929	0.13	0.39	NO
13	TUBA4A	TUBA4A	TUBA4A	4137	0.12	0.4	NO
14	TUBB2C	TUBB2C	TUBB2C	4546	0.11	0.38	NO
15	TUBB4	TUBB4	TUBB4	4727	0.1	0.38	NO
16	ACTG1	ACTG1	ACTG1	5502	0.081	0.35	NO
17	ACTB	ACTB	ACTB	5873	0.072	0.34	NO
18	ARPC1A	ARPC1A	ARPC1A	6239	0.063	0.32	NO
19	ARPC1B	ARPC1B	ARPC1B	6262	0.062	0.33	NO
20	TUBB2B	TUBB2B	TUBB2B	6556	0.055	0.32	NO
21	TUBA1B	TUBA1B	TUBA1B	6697	0.052	0.32	NO
22	ARPC5L	ARPC5L	ARPC5L	6888	0.048	0.31	NO
23	NCK2	NCK2	NCK2	7072	0.044	0.3	NO
24	TUBB	TUBB	TUBB	7353	0.037	0.29	NO
25	OCLN	OCLN	OCLN	7672	0.03	0.28	NO
26	CTTN	CTTN	CTTN	7776	0.028	0.27	NO
27	KRT18	KRT18	KRT18	7969	0.023	0.27	NO
28	ARPC4	ARPC4	ARPC4	8376	0.014	0.24	NO
29	TUBA3C	TUBA3C	TUBA3C	8591	0.0095	0.23	NO
30	WAS	WAS	WAS	8708	0.0074	0.23	NO
31	YWHAQ	YWHAQ	YWHAQ	8836	0.0044	0.22	NO
32	CTNNB1	CTNNB1	CTNNB1	8855	0.0039	0.22	NO
33	ARPC2	ARPC2	ARPC2	8867	0.0037	0.22	NO
34	ABL1	ABL1	ABL1	9176	-0.0034	0.2	NO
35	RHOA	RHOA	RHOA	10371	-0.028	0.14	NO
36	EZR	EZR	EZR	11659	-0.057	0.075	NO
37	CDH1	CDH1	CDH1	11813	-0.06	0.073	NO
38	TUBB1	TUBB1	TUBB1	12083	-0.066	0.065	NO
39	ARHGEF2	ARHGEF2	ARHGEF2	12209	-0.069	0.065	NO
40	YWHAZ	YWHAZ	YWHAZ	12618	-0.078	0.05	NO
41	ARPC5	ARPC5	ARPC5	12792	-0.082	0.049	NO
42	ITGB1	ITGB1	ITGB1	13042	-0.088	0.044	NO
43	HCLS1	HCLS1	HCLS1	13678	-0.1	0.02	NO
44	CLDN1	CLDN1	CLDN1	13769	-0.11	0.026	NO
45	NCK1	NCK1	NCK1	14182	-0.12	0.015	NO
46	PRKCA	PRKCA	PRKCA	14204	-0.12	0.026	NO
47	WASL	WASL	WASL	14227	-0.12	0.036	NO
48	CDC42	CDC42	CDC42	14317	-0.12	0.044	NO
49	NCL	NCL	NCL	15015	-0.14	0.02	NO
50	ARPC3	ARPC3	ARPC3	15902	-0.17	-0.012	NO
51	TLR5	TLR5	TLR5	16162	-0.18	-0.0079	NO
52	FYN	FYN	FYN	16333	-0.19	0.0019	NO
53	ROCK2	ROCK2	ROCK2	16622	-0.2	0.0066	NO
54	ROCK1	ROCK1	ROCK1	16656	-0.2	0.026	NO
55	LY96	LY96	LY96	17314	-0.25	0.014	NO
56	TLR4	TLR4	TLR4	17568	-0.28	0.029	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HIST1H4K	HIST1H4K	HIST1H4K	4	1.8	0.059	YES
2	HIST1H2BO	HIST1H2BO	HIST1H2BO	50	1.4	0.1	YES
3	HIST2H2AC	HIST2H2AC	HIST2H2AC	64	1.3	0.14	YES
4	HIST1H2AJ	HIST1H2AJ	HIST1H2AJ	142	1	0.17	YES
5	HIST2H3C	HIST2H3C	HIST2H3C	148	0.98	0.2	YES
6	HIST3H2A	HIST3H2A	HIST3H2A	237	0.83	0.22	YES
7	HIST1H2BN	HIST1H2BN	HIST1H2BN	260	0.8	0.25	YES
8	HIST2H3D	HIST2H3D	HIST2H3D	290	0.76	0.27	YES
9	HIST1H2BE	HIST1H2BE	HIST1H2BE	304	0.74	0.3	YES
10	FCGR2C	FCGR2C	FCGR2C	326	0.72	0.32	YES
11	HIST1H2BL	HIST1H2BL	HIST1H2BL	379	0.65	0.34	YES
12	HIST1H4J	HIST1H4J	HIST1H4J	409	0.62	0.36	YES
13	H2AFB1	H2AFB1	H2AFB1	508	0.55	0.37	YES
14	HIST2H4A	HIST2H4A	HIST2H4A	628	0.48	0.38	YES
15	HIST1H4I	HIST1H4I	HIST1H4I	653	0.47	0.39	YES
16	HIST1H3H	HIST1H3H	HIST1H3H	673	0.46	0.41	YES
17	HIST2H2BF	HIST2H2BF	HIST2H2BF	677	0.46	0.42	YES
18	H3F3C	H3F3C	H3F3C	697	0.45	0.44	YES
19	HIST1H4B	HIST1H4B	HIST1H4B	705	0.45	0.45	YES
20	FCGR3B	FCGR3B	FCGR3B	736	0.44	0.46	YES
21	FCGR1A	FCGR1A	FCGR1A	761	0.42	0.48	YES
22	HLA-DRB5	HLA-DRB5	HLA-DRB5	764	0.42	0.49	YES
23	C8G	C8G	C8G	776	0.42	0.5	YES
24	HIST1H4A	HIST1H4A	HIST1H4A	820	0.4	0.51	YES
25	HIST1H2AG	HIST1H2AG	HIST1H2AG	823	0.4	0.53	YES
26	HLA-DQA2	HLA-DQA2	HLA-DQA2	860	0.39	0.54	YES
27	HIST1H2AM	HIST1H2AM	HIST1H2AM	869	0.39	0.55	YES
28	HIST1H4E	HIST1H4E	HIST1H4E	893	0.38	0.56	YES
29	HIST1H2BH	HIST1H2BH	HIST1H2BH	935	0.37	0.57	YES
30	HIST1H3D	HIST1H3D	HIST1H3D	1025	0.35	0.58	YES
31	HIST3H2BB	HIST3H2BB	HIST3H2BB	1050	0.35	0.59	YES
32	HIST1H2BJ	HIST1H2BJ	HIST1H2BJ	1193	0.32	0.59	YES
33	HIST1H2BG	HIST1H2BG	HIST1H2BG	1333	0.29	0.59	YES
34	HIST3H3	HIST3H3	HIST3H3	1339	0.29	0.6	YES
35	FCGR2B	FCGR2B	FCGR2B	1343	0.29	0.61	YES
36	HIST1H2AL	HIST1H2AL	HIST1H2AL	1399	0.28	0.62	YES
37	HIST1H2BF	HIST1H2BF	HIST1H2BF	1462	0.28	0.62	YES
38	HIST1H2AB	HIST1H2AB	HIST1H2AB	1576	0.26	0.62	YES
39	ELANE	ELANE	ELANE	1647	0.26	0.63	YES
40	H2AFX	H2AFX	H2AFX	1714	0.25	0.63	YES
41	HIST1H3G	HIST1H3G	HIST1H3G	1720	0.25	0.64	YES
42	HIST1H2BI	HIST1H2BI	HIST1H2BI	1771	0.24	0.65	YES
43	HIST1H2AE	HIST1H2AE	HIST1H2AE	1886	0.23	0.65	YES
44	HIST1H3B	HIST1H3B	HIST1H3B	1897	0.23	0.66	YES
45	HIST1H2BC	HIST1H2BC	HIST1H2BC	2045	0.22	0.65	YES
46	HLA-DQB1	HLA-DQB1	HLA-DQB1	2085	0.22	0.66	YES
47	HLA-DRB1	HLA-DRB1	HLA-DRB1	2090	0.22	0.67	YES
48	HIST1H4C	HIST1H4C	HIST1H4C	2115	0.21	0.67	YES
49	HIST1H3F	HIST1H3F	HIST1H3F	2139	0.21	0.68	YES
50	HIST1H3J	HIST1H3J	HIST1H3J	2309	0.2	0.67	YES
51	HIST1H2AH	HIST1H2AH	HIST1H2AH	2381	0.2	0.68	YES
52	HIST1H2AK	HIST1H2AK	HIST1H2AK	2455	0.19	0.68	YES
53	C1QC	C1QC	C1QC	2763	0.18	0.67	NO
54	C1QB	C1QB	C1QB	2928	0.17	0.66	NO
55	HLA-DQA1	HLA-DQA1	HLA-DQA1	3138	0.16	0.66	NO
56	H2AFJ	H2AFJ	H2AFJ	3271	0.15	0.66	NO
57	HIST1H4D	HIST1H4D	HIST1H4D	3497	0.14	0.65	NO
58	TNF	TNF	TNF	3554	0.14	0.65	NO
59	HIST1H2BK	HIST1H2BK	HIST1H2BK	3734	0.14	0.64	NO
60	HIST2H2AB	HIST2H2AB	HIST2H2AB	3847	0.13	0.64	NO
61	HLA-DPB1	HLA-DPB1	HLA-DPB1	4164	0.12	0.63	NO
62	HLA-DMB	HLA-DMB	HLA-DMB	4222	0.12	0.63	NO
63	HIST1H3I	HIST1H3I	HIST1H3I	4589	0.11	0.61	NO
64	HIST1H3A	HIST1H3A	HIST1H3A	4736	0.1	0.61	NO
65	C4A	C4A	C4A	5055	0.094	0.59	NO
66	GRIN2B	GRIN2B	GRIN2B	5369	0.085	0.58	NO
67	HIST1H3C	HIST1H3C	HIST1H3C	5709	0.076	0.56	NO
68	H3F3A	H3F3A	H3F3A	5714	0.076	0.56	NO
69	SNRPB	SNRPB	SNRPB	5732	0.075	0.56	NO
70	HIST1H2BD	HIST1H2BD	HIST1H2BD	5743	0.075	0.57	NO
71	HIST1H4H	HIST1H4H	HIST1H4H	5842	0.072	0.56	NO
72	CD40	CD40	CD40	5856	0.072	0.57	NO
73	HLA-DMA	HLA-DMA	HLA-DMA	5966	0.069	0.56	NO
74	C1QA	C1QA	C1QA	6007	0.068	0.56	NO
75	CD80	CD80	CD80	6062	0.067	0.56	NO
76	HLA-DPA1	HLA-DPA1	HLA-DPA1	6083	0.066	0.56	NO
77	IL10	IL10	IL10	6103	0.066	0.56	NO
78	H2AFY2	H2AFY2	H2AFY2	6227	0.063	0.56	NO
79	HLA-DRA	HLA-DRA	HLA-DRA	6447	0.057	0.55	NO
80	HIST1H2BM	HIST1H2BM	HIST1H2BM	7370	0.037	0.5	NO
81	HIST1H2AC	HIST1H2AC	HIST1H2AC	7750	0.028	0.48	NO
82	HLA-DOB	HLA-DOB	HLA-DOB	7959	0.023	0.47	NO
83	C9	C9	C9	8047	0.021	0.46	NO
84	HIST1H3E	HIST1H3E	HIST1H3E	8501	0.012	0.44	NO
85	H2AFZ	H2AFZ	H2AFZ	8833	0.0044	0.42	NO
86	H2AFY	H2AFY	H2AFY	8858	0.0038	0.42	NO
87	FCGR2A	FCGR2A	FCGR2A	9013	0.00087	0.41	NO
88	HLA-DOA	HLA-DOA	HLA-DOA	9054	-0.00026	0.41	NO
89	ACTN4	ACTN4	ACTN4	9284	-0.0058	0.4	NO
90	TRIM21	TRIM21	TRIM21	9412	-0.0084	0.39	NO
91	C2	C2	C2	9429	-0.0087	0.39	NO
92	ACTN1	ACTN1	ACTN1	9993	-0.021	0.36	NO
93	ACTN2	ACTN2	ACTN2	10045	-0.022	0.36	NO
94	HIST1H2AD	HIST1H2AD	HIST1H2AD	10435	-0.03	0.33	NO
95	C1R	C1R	C1R	10569	-0.032	0.33	NO
96	H2AFV	H2AFV	H2AFV	10751	-0.036	0.32	NO
97	HIST2H2BE	HIST2H2BE	HIST2H2BE	10976	-0.042	0.31	NO
98	ACTN3	ACTN3	ACTN3	11026	-0.043	0.31	NO
99	SNRPD3	SNRPD3	SNRPD3	11166	-0.046	0.3	NO
100	CD40LG	CD40LG	CD40LG	11176	-0.046	0.3	NO
101	C3	C3	C3	11188	-0.046	0.3	NO
102	CTSG	CTSG	CTSG	11297	-0.049	0.3	NO
103	C1S	C1S	C1S	12342	-0.072	0.24	NO
104	SNRPD1	SNRPD1	SNRPD1	12879	-0.084	0.22	NO
105	CD86	CD86	CD86	13107	-0.09	0.21	NO
106	FCGR3A	FCGR3A	FCGR3A	13141	-0.091	0.21	NO
107	H3F3B	H3F3B	H3F3B	13164	-0.091	0.21	NO
108	HIST4H4	HIST4H4	HIST4H4	15234	-0.15	0.098	NO
109	CD28	CD28	CD28	15561	-0.16	0.085	NO
110	C5	C5	C5	16264	-0.18	0.052	NO
111	C7	C7	C7	16342	-0.19	0.054	NO
112	IFNG	IFNG	IFNG	16388	-0.19	0.058	NO
113	C6	C6	C6	16982	-0.22	0.032	NO
114	TROVE2	TROVE2	TROVE2	17127	-0.23	0.032	NO
115	SSB	SSB	SSB	17743	-0.3	0.0075	NO
116	GRIN2A	GRIN2A	GRIN2A	17953	-0.36	0.0076	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRPS1L1	PRPS1L1	PRPS1L1	239	0.82	0.23	YES
2	LOC729020	LOC729020	LOC729020	399	0.63	0.41	YES
3	PGLS	PGLS	PGLS	1601	0.26	0.42	YES
4	FBP2	FBP2	FBP2	3009	0.16	0.39	YES
5	ALDOC	ALDOC	ALDOC	3932	0.13	0.37	YES
6	G6PD	G6PD	G6PD	4206	0.12	0.39	YES
7	FBP1	FBP1	FBP1	4485	0.11	0.41	YES
8	PFKL	PFKL	PFKL	4670	0.1	0.43	YES
9	TKT	TKT	TKT	5311	0.087	0.42	YES
10	PGM1	PGM1	PGM1	5625	0.078	0.43	YES
11	PGD	PGD	PGD	5682	0.076	0.45	YES
12	PFKP	PFKP	PFKP	5930	0.07	0.45	YES
13	GPI	GPI	GPI	6175	0.064	0.46	YES
14	RBKS	RBKS	RBKS	6346	0.06	0.47	YES
15	ALDOB	ALDOB	ALDOB	6625	0.053	0.47	YES
16	TALDO1	TALDO1	TALDO1	7038	0.044	0.46	NO
17	TKTL1	TKTL1	TKTL1	7611	0.031	0.44	NO
18	PFKM	PFKM	PFKM	8273	0.016	0.4	NO
19	PRPS1	PRPS1	PRPS1	9089	-0.0012	0.36	NO
20	PRPS2	PRPS2	PRPS2	9569	-0.012	0.34	NO
21	DERA	DERA	DERA	10042	-0.022	0.32	NO
22	RPIA	RPIA	RPIA	10813	-0.038	0.28	NO
23	H6PD	H6PD	H6PD	11499	-0.053	0.26	NO
24	TKTL2	TKTL2	TKTL2	12818	-0.083	0.21	NO
25	PGM2	PGM2	PGM2	13668	-0.1	0.2	NO
26	RPE	RPE	RPE	15761	-0.16	0.13	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Methods & Data

Made with Nozzle

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ALOX12	ALOX12	ALOX12	111	1.1	0.14	YES
2	LTC4S	LTC4S	LTC4S	199	0.88	0.25	YES
3	CYP4F2	CYP4F2	CYP4F2	1270	0.3	0.23	YES
4	PLA2G4E	PLA2G4E	PLA2G4E	1448	0.28	0.25	YES
5	CBR3	CBR3	CBR3	2035	0.22	0.25	YES
6	GPX4	GPX4	GPX4	2216	0.21	0.27	YES
7	GGT1	GGT1	GGT1	2250	0.2	0.29	YES
8	JMJD7-PLA2G4B	JMJD7-PLA2G4B	JMJD7-PLA2G4B	2259	0.2	0.32	YES
9	GPX1	GPX1	GPX1	2277	0.2	0.34	YES
10	ALOX12B	ALOX12B	ALOX12B	2413	0.19	0.36	YES
11	PTGES2	PTGES2	PTGES2	2520	0.19	0.38	YES
12	PTGDS	PTGDS	PTGDS	2528	0.19	0.4	YES
13	CYP2C9	CYP2C9	CYP2C9	2794	0.17	0.41	YES
14	ALOX15	ALOX15	ALOX15	3366	0.15	0.4	YES
15	PLA2G12B	PLA2G12B	PLA2G12B	3394	0.15	0.42	YES
16	CBR1	CBR1	CBR1	3530	0.14	0.43	YES
17	PLA2G6	PLA2G6	PLA2G6	3749	0.14	0.44	YES
18	PLA2G1B	PLA2G1B	PLA2G1B	3873	0.13	0.45	YES
19	PLA2G10	PLA2G10	PLA2G10	4030	0.12	0.45	YES
20	CYP4F3	CYP4F3	CYP4F3	4055	0.12	0.47	YES
21	GPX7	GPX7	GPX7	4097	0.12	0.48	YES
22	CYP2C19	CYP2C19	CYP2C19	4195	0.12	0.49	YES
23	CYP2E1	CYP2E1	CYP2E1	4263	0.12	0.5	YES
24	PLA2G2A	PLA2G2A	PLA2G2A	4342	0.12	0.52	YES
25	ALOX5	ALOX5	ALOX5	4706	0.1	0.51	NO
26	CYP2C18	CYP2C18	CYP2C18	5481	0.082	0.48	NO
27	CYP2B6	CYP2B6	CYP2B6	5951	0.07	0.46	NO
28	GGT6	GGT6	GGT6	6214	0.063	0.45	NO
29	PLA2G2F	PLA2G2F	PLA2G2F	6414	0.058	0.45	NO
30	GPX3	GPX3	GPX3	6445	0.058	0.46	NO
31	GPX2	GPX2	GPX2	6815	0.05	0.44	NO
32	PLA2G3	PLA2G3	PLA2G3	7125	0.043	0.43	NO
33	GGT7	GGT7	GGT7	7143	0.042	0.44	NO
34	AKR1C3	AKR1C3	AKR1C3	7164	0.042	0.44	NO
35	PTGES	PTGES	PTGES	7520	0.034	0.42	NO
36	EPHX2	EPHX2	EPHX2	7807	0.027	0.41	NO
37	CYP2C8	CYP2C8	CYP2C8	9030	0.0004	0.34	NO
38	PLA2G2D	PLA2G2D	PLA2G2D	9242	-0.0049	0.33	NO
39	PLA2G12A	PLA2G12A	PLA2G12A	9402	-0.0082	0.32	NO
40	LTA4H	LTA4H	LTA4H	10823	-0.038	0.25	NO
41	PLA2G5	PLA2G5	PLA2G5	11072	-0.044	0.24	NO
42	GGT5	GGT5	GGT5	11186	-0.046	0.24	NO
43	ALOX15B	ALOX15B	ALOX15B	11243	-0.047	0.25	NO
44	TBXAS1	TBXAS1	TBXAS1	11363	-0.05	0.25	NO
45	PTGS1	PTGS1	PTGS1	11830	-0.061	0.23	NO
46	CYP4A11	CYP4A11	CYP4A11	12774	-0.082	0.19	NO
47	HPGDS	HPGDS	HPGDS	14090	-0.11	0.13	NO
48	PTGS2	PTGS2	PTGS2	15769	-0.16	0.058	NO
49	PTGIS	PTGIS	PTGIS	15846	-0.17	0.076	NO
50	PLA2G4A	PLA2G4A	PLA2G4A	16033	-0.18	0.089	NO
51	CYP2U1	CYP2U1	CYP2U1	16446	-0.19	0.091	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NCF1C	NCF1C	NCF1C	149	0.98	0.24	YES
2	GNGT1	GNGT1	GNGT1	330	0.72	0.41	YES
3	FPR1	FPR1	FPR1	1522	0.27	0.41	YES
4	HRAS	HRAS	HRAS	3665	0.14	0.33	NO
5	MAP2K2	MAP2K2	MAP2K2	4098	0.12	0.33	NO
6	MAPK3	MAPK3	MAPK3	4479	0.11	0.34	NO
7	CAMK1G	CAMK1G	CAMK1G	5302	0.087	0.32	NO
8	CAMK1	CAMK1	CAMK1	5468	0.082	0.33	NO
9	ELK1	ELK1	ELK1	6762	0.051	0.27	NO
10	NFKBIA	NFKBIA	NFKBIA	6929	0.047	0.27	NO
11	NFATC3	NFATC3	NFATC3	7091	0.043	0.27	NO
12	NFATC4	NFATC4	NFATC4	7317	0.038	0.27	NO
13	CALM3	CALM3	CALM3	7429	0.036	0.27	NO
14	RELA	RELA	RELA	7570	0.032	0.27	NO
15	RAF1	RAF1	RAF1	7646	0.031	0.28	NO
16	MAP2K3	MAP2K3	MAP2K3	7937	0.024	0.27	NO
17	NFATC1	NFATC1	NFATC1	8289	0.016	0.25	NO
18	MAP2K6	MAP2K6	MAP2K6	8461	0.012	0.25	NO
19	GNB1	GNB1	GNB1	8525	0.011	0.24	NO
20	NCF2	NCF2	NCF2	8972	0.0017	0.22	NO
21	NFATC2	NFATC2	NFATC2	9420	-0.0086	0.2	NO
22	MAPK14	MAPK14	MAPK14	9670	-0.014	0.19	NO
23	NFKB1	NFKB1	NFKB1	9880	-0.018	0.18	NO
24	CALM1	CALM1	CALM1	10583	-0.033	0.15	NO
25	PAK1	PAK1	PAK1	11006	-0.042	0.14	NO
26	PPP3CB	PPP3CB	PPP3CB	11139	-0.045	0.14	NO
27	RAC1	RAC1	RAC1	11233	-0.047	0.15	NO
28	PPP3CC	PPP3CC	PPP3CC	11281	-0.048	0.16	NO
29	MAPK1	MAPK1	MAPK1	11712	-0.058	0.15	NO
30	MAP2K1	MAP2K1	MAP2K1	12012	-0.064	0.15	NO
31	CALM2	CALM2	CALM2	12394	-0.073	0.15	NO
32	PPP3CA	PPP3CA	PPP3CA	14952	-0.14	0.039	NO
33	MAP3K1	MAP3K1	MAP3K1	15933	-0.17	0.028	NO
34	PLCB1	PLCB1	PLCB1	17966	-0.36	0.0069	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPL21	RPL21	RPL21	37	1.4	0.11	YES
2	RPL36A	RPL36A	RPL36A	140	1	0.18	YES
3	RPS28	RPS28	RPS28	318	0.73	0.23	YES
4	RPL39	RPL39	RPL39	327	0.72	0.28	YES
5	RPL9	RPL9	RPL9	451	0.59	0.32	YES
6	RPL7	RPL7	RPL7	562	0.51	0.36	YES
7	RPS26	RPS26	RPS26	588	0.49	0.39	YES
8	RPS27	RPS27	RPS27	619	0.48	0.43	YES
9	RPL18A	RPL18A	RPL18A	699	0.45	0.46	YES
10	RPS3A	RPS3A	RPS3A	1215	0.31	0.45	YES
11	RPSA	RPSA	RPSA	1652	0.26	0.45	YES
12	RPL23A	RPL23A	RPL23A	1804	0.24	0.46	YES
13	RPS15	RPS15	RPS15	1993	0.22	0.47	YES
14	RPL10L	RPL10L	RPL10L	2229	0.21	0.47	YES
15	RPS2	RPS2	RPS2	2261	0.2	0.48	YES
16	RPS5	RPS5	RPS5	2705	0.18	0.47	YES
17	RPL13	RPL13	RPL13	2880	0.17	0.48	YES
18	RPL29	RPL29	RPL29	3123	0.16	0.48	YES
19	RPL10	RPL10	RPL10	3168	0.16	0.48	YES
20	RPLP0	RPLP0	RPLP0	3276	0.15	0.49	YES
21	RPL28	RPL28	RPL28	3461	0.14	0.49	YES
22	RPL41	RPL41	RPL41	4194	0.12	0.46	NO
23	UBA52	UBA52	UBA52	4353	0.11	0.46	NO
24	RPLP2	RPLP2	RPLP2	5002	0.095	0.43	NO
25	RPL8	RPL8	RPL8	5111	0.092	0.43	NO
26	RPS3	RPS3	RPS3	5146	0.091	0.44	NO
27	RPS10	RPS10	RPS10	5230	0.089	0.44	NO
28	RPL15	RPL15	RPL15	5388	0.084	0.44	NO
29	RPS9	RPS9	RPS9	5460	0.083	0.44	NO
30	RPL36	RPL36	RPL36	5632	0.078	0.44	NO
31	RPS16	RPS16	RPS16	6150	0.065	0.41	NO
32	RPS6	RPS6	RPS6	6308	0.061	0.41	NO
33	FAU	FAU	FAU	6372	0.059	0.41	NO
34	RPL27	RPL27	RPL27	6745	0.051	0.39	NO
35	RPLP1	RPLP1	RPLP1	7062	0.044	0.38	NO
36	RPL3	RPL3	RPL3	7161	0.042	0.38	NO
37	RPS21	RPS21	RPS21	7286	0.039	0.37	NO
38	RPL26L1	RPL26L1	RPL26L1	7289	0.039	0.38	NO
39	RPS11	RPS11	RPS11	7407	0.036	0.37	NO
40	RPL7A	RPL7A	RPL7A	7572	0.032	0.37	NO
41	RPL10A	RPL10A	RPL10A	7676	0.03	0.36	NO
42	RPL35	RPL35	RPL35	7727	0.029	0.36	NO
43	RPS13	RPS13	RPS13	7868	0.025	0.36	NO
44	RPS8	RPS8	RPS8	7919	0.024	0.36	NO
45	RPS19	RPS19	RPS19	8008	0.022	0.35	NO
46	RPS4X	RPS4X	RPS4X	8057	0.021	0.35	NO
47	RPL27A	RPL27A	RPL27A	8324	0.016	0.34	NO
48	RPL17	RPL17	RPL17	8331	0.015	0.34	NO
49	RPL38	RPL38	RPL38	8341	0.015	0.34	NO
50	RPS15A	RPS15A	RPS15A	8487	0.012	0.33	NO
51	RPS4Y1	RPS4Y1	RPS4Y1	8553	0.011	0.33	NO
52	RPL32	RPL32	RPL32	8711	0.0074	0.32	NO
53	RPL19	RPL19	RPL19	9234	-0.0048	0.29	NO
54	RPL6	RPL6	RPL6	9303	-0.0062	0.29	NO
55	RPL37A	RPL37A	RPL37A	9445	-0.0091	0.28	NO
56	RPL13A	RPL13A	RPL13A	9741	-0.016	0.27	NO
57	RPL23	RPL23	RPL23	9995	-0.021	0.25	NO
58	RPL30	RPL30	RPL30	10003	-0.021	0.26	NO
59	RPL37	RPL37	RPL37	10128	-0.024	0.25	NO
60	RPS17	RPS17	RPS17	10303	-0.027	0.24	NO
61	MRPL13	MRPL13	MRPL13	10470	-0.03	0.24	NO
62	RPL35A	RPL35A	RPL35A	10540	-0.032	0.24	NO
63	RPL31	RPL31	RPL31	10902	-0.04	0.22	NO
64	RPS29	RPS29	RPS29	10967	-0.041	0.22	NO
65	RPL5	RPL5	RPL5	11019	-0.042	0.22	NO
66	RPS23	RPS23	RPS23	11197	-0.046	0.21	NO
67	RPL11	RPL11	RPL11	11230	-0.047	0.21	NO
68	RPL4	RPL4	RPL4	11395	-0.051	0.21	NO
69	RPL36AL	RPL36AL	RPL36AL	11617	-0.056	0.2	NO
70	RPL34	RPL34	RPL34	11791	-0.06	0.2	NO
71	RPL14	RPL14	RPL14	11809	-0.06	0.2	NO
72	RPL22	RPL22	RPL22	12535	-0.076	0.16	NO
73	RPL26	RPL26	RPL26	12636	-0.079	0.16	NO
74	RPS20	RPS20	RPS20	13097	-0.09	0.15	NO
75	RPS7	RPS7	RPS7	13431	-0.097	0.14	NO
76	RPS18	RPS18	RPS18	14034	-0.11	0.11	NO
77	RPS24	RPS24	RPS24	14272	-0.12	0.11	NO
78	RPL12	RPL12	RPL12	14677	-0.13	0.095	NO
79	RSL24D1	RSL24D1	RSL24D1	14843	-0.14	0.096	NO
80	RPL24	RPL24	RPL24	15139	-0.14	0.091	NO
81	RPS25	RPS25	RPS25	15256	-0.15	0.096	NO
82	RPS12	RPS12	RPS12	15468	-0.16	0.097	NO
83	RPS27L	RPS27L	RPS27L	16405	-0.19	0.059	NO
84	RPS27A	RPS27A	RPS27A	16464	-0.19	0.071	NO
85	RPL22L1	RPL22L1	RPL22L1	17299	-0.25	0.044	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	POLR2J2	POLR2J2	POLR2J2	285	0.77	0.19	YES
2	POLR2J3	POLR2J3	POLR2J3	813	0.41	0.27	YES
3	POLR2I	POLR2I	POLR2I	1635	0.26	0.3	YES
4	POLR2L	POLR2L	POLR2L	2608	0.18	0.29	YES
5	POLR2G	POLR2G	POLR2G	2659	0.18	0.34	YES
6	ZNRD1	ZNRD1	ZNRD1	4588	0.11	0.26	YES
7	POLR3K	POLR3K	POLR3K	4760	0.1	0.28	YES
8	POLR3H	POLR3H	POLR3H	4775	0.1	0.31	YES
9	POLR1C	POLR1C	POLR1C	4897	0.098	0.33	YES
10	POLR2J	POLR2J	POLR2J	5007	0.095	0.35	YES
11	POLR2F	POLR2F	POLR2F	5290	0.087	0.35	YES
12	POLR2E	POLR2E	POLR2E	5371	0.085	0.37	YES
13	POLR2C	POLR2C	POLR2C	7073	0.044	0.29	NO
14	POLR3D	POLR3D	POLR3D	7753	0.028	0.26	NO
15	POLR2D	POLR2D	POLR2D	7790	0.027	0.27	NO
16	POLR3C	POLR3C	POLR3C	8398	0.014	0.24	NO
17	POLR3B	POLR3B	POLR3B	9236	-0.0049	0.19	NO
18	POLR3A	POLR3A	POLR3A	9258	-0.0052	0.19	NO
19	POLR1E	POLR1E	POLR1E	9516	-0.011	0.18	NO
20	POLR1B	POLR1B	POLR1B	10485	-0.031	0.13	NO
21	POLR1A	POLR1A	POLR1A	11399	-0.051	0.098	NO
22	POLR2B	POLR2B	POLR2B	11702	-0.058	0.097	NO
23	POLR2A	POLR2A	POLR2A	11801	-0.06	0.11	NO
24	POLR1D	POLR1D	POLR1D	12276	-0.071	0.1	NO
25	POLR3F	POLR3F	POLR3F	15281	-0.15	-0.026	NO
26	POLR2K	POLR2K	POLR2K	16131	-0.18	-0.024	NO
27	POLR3GL	POLR3GL	POLR3GL	17062	-0.23	-0.014	NO
28	POLR3G	POLR3G	POLR3G	17446	-0.26	0.036	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GSTM1	GSTM1	GSTM1	402	0.63	0.09	YES
2	GSTT2	GSTT2	GSTT2	1053	0.35	0.12	YES
3	GSTA2	GSTA2	GSTA2	1216	0.31	0.16	YES
4	GSTM2	GSTM2	GSTM2	1631	0.26	0.19	YES
5	GSTO2	GSTO2	GSTO2	1988	0.22	0.21	YES
6	SRM	SRM	SRM	2145	0.21	0.24	YES
7	GPX4	GPX4	GPX4	2216	0.21	0.27	YES
8	GGT1	GGT1	GGT1	2250	0.2	0.3	YES
9	GPX1	GPX1	GPX1	2277	0.2	0.34	YES
10	OPLAH	OPLAH	OPLAH	2353	0.2	0.37	YES
11	GSTP1	GSTP1	GSTP1	3178	0.16	0.35	YES
12	ANPEP	ANPEP	ANPEP	3406	0.15	0.36	YES
13	GPX7	GPX7	GPX7	4097	0.12	0.35	YES
14	G6PD	G6PD	G6PD	4206	0.12	0.36	YES
15	GSTZ1	GSTZ1	GSTZ1	4644	0.1	0.36	YES
16	IDH2	IDH2	IDH2	4717	0.1	0.37	YES
17	GSTM3	GSTM3	GSTM3	4872	0.098	0.38	YES
18	GSS	GSS	GSS	6011	0.068	0.33	NO
19	GSTT1	GSTT1	GSTT1	6047	0.067	0.34	NO
20	GGT6	GGT6	GGT6	6214	0.063	0.34	NO
21	GPX3	GPX3	GPX3	6445	0.058	0.34	NO
22	GSTM5	GSTM5	GSTM5	6672	0.052	0.34	NO
23	GPX2	GPX2	GPX2	6815	0.05	0.34	NO
24	GSR	GSR	GSR	6990	0.046	0.34	NO
25	ODC1	ODC1	ODC1	7045	0.044	0.34	NO
26	GGT7	GGT7	GGT7	7143	0.042	0.34	NO
27	GSTK1	GSTK1	GSTK1	7154	0.042	0.35	NO
28	MGST3	MGST3	MGST3	7469	0.035	0.34	NO
29	GSTM4	GSTM4	GSTM4	7474	0.035	0.35	NO
30	MGST1	MGST1	MGST1	7758	0.028	0.34	NO
31	GSTO1	GSTO1	GSTO1	8236	0.017	0.31	NO
32	RRM2	RRM2	RRM2	9044	0.000025	0.27	NO
33	GSTA1	GSTA1	GSTA1	9331	-0.0067	0.25	NO
34	LAP3	LAP3	LAP3	10327	-0.028	0.2	NO
35	IDH1	IDH1	IDH1	10996	-0.042	0.17	NO
36	GGT5	GGT5	GGT5	11186	-0.046	0.17	NO
37	TXNDC12	TXNDC12	TXNDC12	11938	-0.063	0.14	NO
38	MGST2	MGST2	MGST2	12532	-0.076	0.12	NO
39	RRM1	RRM1	RRM1	13075	-0.089	0.11	NO
40	GCLC	GCLC	GCLC	13347	-0.096	0.11	NO
41	GCLM	GCLM	GCLM	14240	-0.12	0.081	NO
42	GGCT	GGCT	GGCT	15244	-0.15	0.052	NO
43	GSTA4	GSTA4	GSTA4	15273	-0.15	0.077	NO
44	SMS	SMS	SMS	16073	-0.18	0.064	NO
45	RRM2B	RRM2B	RRM2B	17489	-0.27	0.033	NO