Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Syndecan-1-mediated signaling events	68.0	2336.0	34.0	-0.724	0.015	1000.0	-1000.0	-0.05	-1000.0
TCGA08_retinoblastoma	32.0	262.0	8.0	-0.136	0.044	1000.0	-1000.0	-0.012	-1000.0
Reelin signaling pathway	22.0	1276.0	56.0	-0.413	0.037	1000.0	-1000.0	-0.08	-1000.0
Glypican 1 network	21.0	1049.0	48.0	-0.437	0.025	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	19.0	919.0	46.0	-0.613	0.023	1000.0	-1000.0	-0.154	-1000.0
Syndecan-4-mediated signaling events	19.0	1278.0	67.0	-0.348	0.058	1000.0	-1000.0	-0.055	-1000.0
Osteopontin-mediated events	17.0	647.0	38.0	-0.181	0.019	1000.0	-1000.0	-0.073	-1000.0
Caspase cascade in apoptosis	16.0	1217.0	74.0	-0.152	0.1	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	15.0	1447.0	91.0	-0.699	0.491	1000.0	-1000.0	-0.215	-1000.0
Signaling events mediated by the Hedgehog family	13.0	696.0	52.0	-0.157	0.146	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	978.0	78.0	-0.099	0.032	1000.0	-1000.0	-0.082	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	351.0	31.0	-0.427	0.012	1000.0	-1000.0	-0.069	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	545.0	54.0	-0.169	0.022	1000.0	-1000.0	-0.095	-1000.0
Glucocorticoid receptor regulatory network	10.0	1209.0	114.0	-0.557	0.213	1000.0	-1000.0	-0.074	-1000.0
Angiopoietin receptor Tie2-mediated signaling	10.0	942.0	88.0	-0.312	0.061	1000.0	-1000.0	-0.091	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	173.0	17.0	-0.062	0.025	1000.0	-1000.0	-0.036	-1000.0
HIF-1-alpha transcription factor network	9.0	756.0	76.0	-0.738	0.02	1000.0	-1000.0	-0.207	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	606.0	61.0	-0.394	0.169	1000.0	-1000.0	-0.054	-1000.0
Endothelins	9.0	937.0	96.0	-0.464	0.176	1000.0	-1000.0	-0.083	-1000.0
TCGA08_p53	9.0	64.0	7.0	-0.102	0.053	1000.0	-1000.0	-0.012	-1000.0
Canonical Wnt signaling pathway	9.0	461.0	51.0	-0.394	0.181	1000.0	-1000.0	-0.065	-1000.0
IL23-mediated signaling events	9.0	585.0	60.0	-0.317	0.016	1000.0	-1000.0	-0.181	-1000.0
Signaling events mediated by PRL	9.0	334.0	34.0	-0.198	0.065	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	8.0	459.0	52.0	-0.282	0.012	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	7.0	603.0	81.0	-0.227	0.038	1000.0	-1000.0	-0.092	-1000.0
Effects of Botulinum toxin	7.0	190.0	26.0	-0.097	0.022	1000.0	-1000.0	-0.041	-1000.0
BCR signaling pathway	7.0	693.0	99.0	-0.09	0.019	1000.0	-1000.0	-0.078	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	224.0	34.0	-0.037	0.012	1000.0	-1000.0	-0.046	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	105.0	17.0	-0.13	0.027	1000.0	-1000.0	-0.043	-1000.0
Syndecan-2-mediated signaling events	6.0	462.0	69.0	-0.318	0.034	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	6.0	397.0	58.0	-0.277	0.025	1000.0	-1000.0	-0.067	-1000.0
Wnt signaling	6.0	45.0	7.0	-0.155	0.012	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	5.0	194.0	38.0	-0.122	0.014	1000.0	-1000.0	-0.036	-1000.0
p75(NTR)-mediated signaling	5.0	734.0	125.0	-0.926	0.037	1000.0	-1000.0	-0.097	-1000.0
amb2 Integrin signaling	5.0	484.0	82.0	-0.261	0.021	1000.0	-1000.0	-0.056	-1000.0
Nectin adhesion pathway	5.0	351.0	63.0	-0.709	0.042	1000.0	-1000.0	-0.063	-1000.0
IL1-mediated signaling events	5.0	340.0	62.0	-0.099	0.026	1000.0	-1000.0	-0.092	-1000.0
Syndecan-3-mediated signaling events	5.0	183.0	35.0	-0.265	0.037	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	252.0	44.0	-0.034	0.012	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	5.0	255.0	51.0	-0.261	0.053	1000.0	-1000.0	-0.076	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	405.0	68.0	-0.427	0.034	1000.0	-1000.0	-0.118	-1000.0
Plasma membrane estrogen receptor signaling	5.0	499.0	86.0	-0.368	0.091	1000.0	-1000.0	-0.079	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	470.0	97.0	-0.107	0.028	1000.0	-1000.0	-0.08	-1000.0
IFN-gamma pathway	4.0	307.0	68.0	-0.093	0.018	1000.0	-1000.0	-0.093	-1000.0
S1P5 pathway	4.0	80.0	17.0	-0.11	0.093	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	4.0	179.0	43.0	-0.171	0.078	1000.0	-1000.0	-0.087	-1000.0
S1P1 pathway	4.0	148.0	36.0	-0.14	0.013	1000.0	-1000.0	-0.059	-1000.0
LPA receptor mediated events	4.0	459.0	102.0	-0.122	0.027	1000.0	-1000.0	-0.087	-1000.0
Glypican 2 network	3.0	12.0	4.0	-0.002	0.004	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	3.0	177.0	52.0	-0.153	0.023	1000.0	-1000.0	-0.05	-1000.0
Regulation of Telomerase	3.0	332.0	102.0	-0.401	0.037	1000.0	-1000.0	-0.103	-1000.0
VEGFR1 specific signals	3.0	198.0	56.0	-0.035	0.031	1000.0	-1000.0	-0.054	-1000.0
FOXM1 transcription factor network	3.0	169.0	51.0	-0.26	0.028	1000.0	-1000.0	-0.224	-1000.0
Aurora B signaling	3.0	226.0	67.0	-0.383	0.078	1000.0	-1000.0	-0.056	-1000.0
ErbB2/ErbB3 signaling events	2.0	140.0	65.0	-0.045	0.037	1000.0	-1000.0	-0.068	-1000.0
IL12-mediated signaling events	2.0	201.0	87.0	-0.135	0.042	1000.0	-1000.0	-0.159	-1000.0
ErbB4 signaling events	2.0	169.0	69.0	-0.159	0.076	1000.0	-1000.0	-0.087	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	73.0	28.0	-0.05	0.023	1000.0	-1000.0	-0.027	-1000.0
Noncanonical Wnt signaling pathway	2.0	69.0	26.0	-0.155	0.012	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	2.0	126.0	60.0	-0.126	0.032	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	183.0	82.0	-0.119	0.012	1000.0	-1000.0	-0.08	-1000.0
Ephrin B reverse signaling	2.0	131.0	48.0	-0.031	0.017	1000.0	-1000.0	-0.038	-1000.0
Integrins in angiogenesis	2.0	202.0	84.0	-0.184	0.03	1000.0	-1000.0	-0.079	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	257.0	93.0	-0.074	0.033	1000.0	-1000.0	-0.08	-1000.0
EPHB forward signaling	2.0	199.0	85.0	-0.055	0.041	1000.0	-1000.0	-0.077	-1000.0
IL6-mediated signaling events	2.0	177.0	75.0	-0.155	0.041	1000.0	-1000.0	-0.095	-1000.0
EGFR-dependent Endothelin signaling events	2.0	60.0	21.0	-0.032	0.018	1000.0	-1000.0	-0.07	-1000.0
PDGFR-beta signaling pathway	2.0	205.0	97.0	-0.103	0.037	1000.0	-1000.0	-0.081	-1000.0
S1P4 pathway	2.0	74.0	25.0	-0.11	0.024	1000.0	-1000.0	-0.035	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	271.0	136.0	-0.111	0.108	1000.0	-1000.0	-0.058	-1000.0
Coregulation of Androgen receptor activity	1.0	133.0	76.0	-0.136	0.043	1000.0	-1000.0	-0.029	-1000.0
Ephrin A  reverse signaling	1.0	9.0	7.0	-0.032	0.009	1000.0	-1000.0	-0.018	-1000.0
Thromboxane A2 receptor signaling	1.0	190.0	105.0	-0.118	0.051	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by PTP1B	1.0	80.0	76.0	-0.098	0.019	1000.0	-1000.0	-0.071	-1000.0
PLK1 signaling events	1.0	160.0	85.0	-0.106	0.026	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	153.0	83.0	-0.279	0.071	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	1.0	129.0	74.0	-0.088	0.032	1000.0	-1000.0	-0.087	-1000.0
S1P3 pathway	1.0	79.0	42.0	-0.083	0.025	1000.0	-1000.0	-0.038	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	64.0	33.0	-0.131	0.034	1000.0	-1000.0	-0.036	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	172.0	120.0	-0.073	0.053	1000.0	-1000.0	-0.067	-1000.0
LPA4-mediated signaling events	0.0	5.0	12.0	-0.017	0.013	1000.0	-1000.0	-0.029	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.009	0.036	1000.0	-1000.0	-0.049	-1000.0
Canonical NF-kappaB pathway	0.0	10.0	39.0	-0.007	0.058	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by HDAC Class II	0.0	5.0	75.0	-0.024	0.033	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	0.0	9.0	57.0	-0.031	0.048	1000.0	-1000.0	-0.066	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.008	0.013	1000.0	-1000.0	-0.016	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.014	0.038	1000.0	-1000.0	-0.054	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.012	0.015	1000.0	-1000.0	-0.025	-1000.0
Cellular roles of Anthrax toxin	0.0	25.0	39.0	-0.009	0.012	1000.0	-1000.0	-0.015	-1000.0
Arf6 signaling events	0.0	51.0	62.0	-0.044	0.032	1000.0	-1000.0	-0.055	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	24.0	85.0	-0.014	0.046	1000.0	-1000.0	-0.071	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	20.0	65.0	-0.079	0.046	1000.0	-1000.0	-0.061	-1000.0
Arf6 downstream pathway	0.0	29.0	43.0	-0.02	0.024	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.023	1000.0	-1000.0	-0.016	-1000.0
EPO signaling pathway	0.0	8.0	55.0	-0.002	0.049	1000.0	-1000.0	-0.083	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.002	0.034	1000.0	-1000.0	-0.049	-1000.0
PDGFR-alpha signaling pathway	0.0	17.0	44.0	-0.002	0.032	1000.0	-1000.0	-0.037	-1000.0
mTOR signaling pathway	0.0	0.0	53.0	-0.001	0.03	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	5.0	68.0	-0.033	0.044	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	0.0	43.0	76.0	-0.017	0.039	1000.0	-1000.0	-0.046	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	0.0	37.0	-0.019	0.035	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	0.0	14.0	40.0	-0.022	0.023	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	0.0	39.0	48.0	-0.05	0.035	1000.0	-1000.0	-0.048	-1000.0
ceramide signaling pathway	0.0	0.0	49.0	0.0	0.042	1000.0	-1000.0	-0.049	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	40.0	52.0	-0.085	0.027	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class I	0.0	11.0	104.0	-0.025	0.041	1000.0	-1000.0	-0.045	-1000.0
FoxO family signaling	0.0	50.0	64.0	-0.122	0.09	1000.0	-1000.0	-0.079	-1000.0
FAS signaling pathway (CD95)	0.0	26.0	47.0	-0.016	0.023	1000.0	-1000.0	-0.055	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	4.0	15.0	-0.1	0.023	1000.0	-1000.0	-0.038	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.031	0.035	1000.0	-1000.0	-0.05	-1000.0
Atypical NF-kappaB pathway	0.0	2.0	31.0	-0.0	0.038	1000.0	-1000.0	-0.044	-1000.0
IL2 signaling events mediated by PI3K	0.0	53.0	58.0	-0.074	0.051	1000.0	-1000.0	-0.064	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	2.0	45.0	-0.003	0.054	1000.0	-1000.0	-0.093	-1000.0
Regulation of p38-alpha and p38-beta	0.0	1.0	54.0	-0.014	0.032	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	95.0	125.0	-0.005	0.06	1000.0	-1000.0	-0.091	-1000.0
TCGA08_rtk_signaling	0.0	14.0	26.0	-0.017	0.037	1000.0	-1000.0	-0.016	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	10.0	74.0	-0.027	0.053	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	9.0	76.0	-0.007	0.044	1000.0	-1000.0	-0.074	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.032	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	0.0	4.0	22.0	0.004	0.056	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events	0.0	17.0	73.0	-0.003	0.03	1000.0	-1000.0	-0.059	-1000.0
Arf6 trafficking events	0.0	44.0	71.0	-0.037	0.032	1000.0	-1000.0	-0.053	-1000.0
IGF1 pathway	0.0	2.0	57.0	-0.02	0.025	1000.0	-1000.0	-0.091	-1000.0
Rapid glucocorticoid signaling	0.0	10.0	20.0	-0.0	0.012	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in keratinocytes	0.0	29.0	43.0	-0.047	0.04	1000.0	-1000.0	-0.045	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.003	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.025	1000.0	-1000.0	-0.021	-1000.0
p38 MAPK signaling pathway	0.0	17.0	44.0	-0.012	0.028	1000.0	-1000.0	-0.063	-1000.0
Arf1 pathway	0.0	16.0	54.0	-0.0	0.025	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.037	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	0.0	59.0	70.0	-0.19	0.024	1000.0	-1000.0	-0.07	-1000.0
Total	560	33248	7203	-19.1557465729	5.76148455867	131000	-131000	-8.13723246289	-131000