GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in SARC-TP

Sarcoma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in SARC-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1DN4449

+ Overview

+ Introduction

+ Summary

basic data info
Number of Gene Sets: 193
Number of samples: 258
Original number of Gene Sets: 404
Maximum gene set size: 388

phenotype info
pheno.type: 1 - 3 :[ clus1 ] 116
pheno.type: 2 - 3 :[ clus2 ] 78
pheno.type: 3 - 3 :[ clus3 ] 64

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA BCR PATHWAY	33	genes.ES.table	0.63	1.8	0.004	0.16	0.26	0.24	0.087	0.22	0	0.036
BIOCARTA FAS PATHWAY	29	genes.ES.table	0.53	1.8	0.018	0.083	0.3	0.66	0.31	0.45	0	0.009
BIOCARTA FCER1 PATHWAY	37	genes.ES.table	0.58	1.7	0.033	0.11	0.58	0.22	0.12	0.19	0.059	0.008
BIOCARTA FMLP PATHWAY	34	genes.ES.table	0.43	1.6	0.051	0.14	0.84	0.088	0.018	0.087	0.092	0.001
BIOCARTA HIVNEF PATHWAY	57	genes.ES.table	0.41	1.6	0.054	0.12	0.64	0.56	0.32	0.38	0.068	0.005
BIOCARTA IL2RB PATHWAY	37	genes.ES.table	0.63	1.8	0.014	0.075	0.36	0.32	0.1	0.29	0	0.006
BIOCARTA GSK3 PATHWAY	26	genes.ES.table	0.53	1.6	0.036	0.13	0.82	0.38	0.2	0.31	0.089	0.001
BIOCARTA DEATH PATHWAY	32	genes.ES.table	0.46	1.5	0.067	0.13	0.84	0.66	0.31	0.46	0.088	0
BIOCARTA NKT PATHWAY	25	genes.ES.table	0.81	1.6	0.004	0.12	0.68	0.8	0.13	0.7	0.072	0.005
BIOCARTA IL1R PATHWAY	31	genes.ES.table	0.54	1.6	0.057	0.14	0.84	0.48	0.25	0.36	0.092	0.001

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HK3	HK3	HK3	12	0.85	0.12	YES
2	GFPT2	GFPT2	GFPT2	107	0.66	0.21	YES
3	NPL	NPL	NPL	148	0.62	0.3	YES
4	RENBP	RENBP	RENBP	318	0.54	0.37	YES
5	UAP1	UAP1	UAP1	1006	0.34	0.38	YES
6	UGDH	UGDH	UGDH	1235	0.3	0.41	YES
7	NANS	NANS	NANS	1524	0.26	0.43	YES
8	AMDHD2	AMDHD2	AMDHD2	1876	0.22	0.44	YES
9	PMM2	PMM2	PMM2	2081	0.2	0.46	YES
10	HK2	HK2	HK2	2087	0.2	0.49	YES
11	GALK1	GALK1	GALK1	2193	0.19	0.51	YES
12	HEXA	HEXA	HEXA	2399	0.18	0.53	YES
13	CHIT1	CHIT1	CHIT1	2454	0.17	0.55	YES
14	GNPNAT1	GNPNAT1	GNPNAT1	2550	0.17	0.57	YES
15	PGM3	PGM3	PGM3	2763	0.15	0.58	YES
16	NAGK	NAGK	NAGK	2801	0.15	0.6	YES
17	GMPPA	GMPPA	GMPPA	3412	0.12	0.58	NO
18	GALE	GALE	GALE	4087	0.096	0.56	NO
19	GMPPB	GMPPB	GMPPB	4089	0.096	0.57	NO
20	HEXB	HEXB	HEXB	4217	0.092	0.58	NO
21	UGP2	UGP2	UGP2	4937	0.07	0.55	NO
22	PMM1	PMM1	PMM1	5811	0.048	0.51	NO
23	GMDS	GMDS	GMDS	5872	0.047	0.51	NO
24	HK1	HK1	HK1	5961	0.045	0.51	NO
25	UXS1	UXS1	UXS1	6486	0.034	0.49	NO
26	GALK2	GALK2	GALK2	6561	0.032	0.49	NO
27	GNPDA1	GNPDA1	GNPDA1	6674	0.03	0.49	NO
28	NANP	NANP	NANP	7262	0.017	0.46	NO
29	PGM1	PGM1	PGM1	7788	0.006	0.43	NO
30	GFPT1	GFPT1	GFPT1	7950	0.0027	0.42	NO
31	TSTA3	TSTA3	TSTA3	8064	8e-05	0.41	NO
32	GPI	GPI	GPI	8168	-0.0019	0.41	NO
33	CYB5R1	CYB5R1	CYB5R1	9214	-0.024	0.36	NO
34	GNE	GNE	GNE	10089	-0.042	0.31	NO
35	MPI	MPI	MPI	10474	-0.05	0.3	NO
36	FPGT	FPGT	FPGT	11036	-0.062	0.28	NO
37	CMAS	CMAS	CMAS	11283	-0.068	0.27	NO
38	FUK	FUK	FUK	11337	-0.069	0.28	NO
39	GALT	GALT	GALT	11923	-0.083	0.26	NO
40	GNPDA2	GNPDA2	GNPDA2	11972	-0.084	0.27	NO
41	PGM2	PGM2	PGM2	12571	-0.1	0.25	NO
42	GCK	GCK	GCK	17108	-0.4	0.058	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD68	CD68	CD68	299	0.55	0.014	YES
2	CTSW	CTSW	CTSW	319	0.54	0.043	YES
3	LAPTM5	LAPTM5	LAPTM5	489	0.47	0.06	YES
4	CTSS	CTSS	CTSS	504	0.47	0.085	YES
5	CTSC	CTSC	CTSC	539	0.46	0.11	YES
6	ACP5	ACP5	ACP5	640	0.43	0.13	YES
7	PLA2G15	PLA2G15	PLA2G15	845	0.37	0.14	YES
8	SLC11A1	SLC11A1	SLC11A1	948	0.35	0.15	YES
9	FUCA1	FUCA1	FUCA1	953	0.35	0.17	YES
10	LGMN	LGMN	LGMN	969	0.34	0.19	YES
11	LAMP3	LAMP3	LAMP3	1108	0.32	0.2	YES
12	CTSZ	CTSZ	CTSZ	1285	0.29	0.2	YES
13	ATP6V0D2	ATP6V0D2	ATP6V0D2	1599	0.25	0.2	YES
14	NAGPA	NAGPA	NAGPA	1600	0.25	0.22	YES
15	CTSL1	CTSL1	CTSL1	1603	0.25	0.23	YES
16	NAPSA	NAPSA	NAPSA	1660	0.24	0.24	YES
17	LIPA	LIPA	LIPA	1684	0.24	0.25	YES
18	NPC2	NPC2	NPC2	1688	0.24	0.26	YES
19	GALC	GALC	GALC	1705	0.24	0.28	YES
20	CTSH	CTSH	CTSH	1759	0.23	0.29	YES
21	CTSB	CTSB	CTSB	1796	0.23	0.3	YES
22	MANBA	MANBA	MANBA	1971	0.21	0.3	YES
23	ACP2	ACP2	ACP2	2054	0.2	0.31	YES
24	CTSD	CTSD	CTSD	2127	0.2	0.31	YES
25	MAN2B1	MAN2B1	MAN2B1	2219	0.19	0.32	YES
26	GLA	GLA	GLA	2254	0.18	0.33	YES
27	IDUA	IDUA	IDUA	2320	0.18	0.33	YES
28	GALNS	GALNS	GALNS	2329	0.18	0.34	YES
29	ARSA	ARSA	ARSA	2332	0.18	0.35	YES
30	CTSA	CTSA	CTSA	2355	0.18	0.36	YES
31	HEXA	HEXA	HEXA	2399	0.18	0.37	YES
32	CTNS	CTNS	CTNS	2410	0.17	0.38	YES
33	NEU1	NEU1	NEU1	2513	0.17	0.38	YES
34	MCOLN1	MCOLN1	MCOLN1	2534	0.17	0.39	YES
35	AP1B1	AP1B1	AP1B1	2545	0.17	0.4	YES
36	PSAP	PSAP	PSAP	2683	0.16	0.4	YES
37	SLC17A5	SLC17A5	SLC17A5	2716	0.16	0.41	YES
38	TCIRG1	TCIRG1	TCIRG1	2723	0.16	0.42	YES
39	ATP6V0B	ATP6V0B	ATP6V0B	2740	0.15	0.42	YES
40	NAGLU	NAGLU	NAGLU	3002	0.14	0.42	YES
41	CTSG	CTSG	CTSG	3011	0.14	0.42	YES
42	GNPTAB	GNPTAB	GNPTAB	3041	0.14	0.43	YES
43	ATP6V0D1	ATP6V0D1	ATP6V0D1	3054	0.14	0.44	YES
44	TPP1	TPP1	TPP1	3145	0.13	0.44	YES
45	SMPD1	SMPD1	SMPD1	3256	0.13	0.44	YES
46	DNASE2B	DNASE2B	DNASE2B	3268	0.13	0.45	YES
47	HYAL1	HYAL1	HYAL1	3297	0.12	0.45	YES
48	GBA	GBA	GBA	3298	0.12	0.46	YES
49	ATP6V0C	ATP6V0C	ATP6V0C	3338	0.12	0.46	YES
50	CLTA	CLTA	CLTA	3339	0.12	0.47	YES
51	ATP6AP1	ATP6AP1	ATP6AP1	3361	0.12	0.48	YES
52	CD63	CD63	CD63	3377	0.12	0.48	YES
53	NAGA	NAGA	NAGA	3391	0.12	0.49	YES
54	GLB1	GLB1	GLB1	3535	0.11	0.49	YES
55	DNASE2	DNASE2	DNASE2	3575	0.11	0.49	YES
56	LAMP2	LAMP2	LAMP2	3602	0.11	0.5	YES
57	ASAH1	ASAH1	ASAH1	3626	0.11	0.5	YES
58	AP3S1	AP3S1	AP3S1	3662	0.11	0.5	YES
59	GNPTG	GNPTG	GNPTG	3713	0.11	0.51	YES
60	LAMP1	LAMP1	LAMP1	3747	0.11	0.51	YES
61	SGSH	SGSH	SGSH	3750	0.11	0.52	YES
62	GM2A	GM2A	GM2A	3848	0.1	0.52	YES
63	CLN3	CLN3	CLN3	4078	0.097	0.51	NO
64	HEXB	HEXB	HEXB	4217	0.092	0.51	NO
65	CTSO	CTSO	CTSO	4268	0.091	0.51	NO
66	SUMF1	SUMF1	SUMF1	4329	0.088	0.51	NO
67	GNS	GNS	GNS	4653	0.078	0.5	NO
68	M6PR	M6PR	M6PR	4851	0.073	0.49	NO
69	GAA	GAA	GAA	4862	0.072	0.5	NO
70	LAPTM4A	LAPTM4A	LAPTM4A	4923	0.071	0.5	NO
71	GUSB	GUSB	GUSB	4945	0.07	0.5	NO
72	AP1S1	AP1S1	AP1S1	4947	0.07	0.5	NO
73	AP1M1	AP1M1	AP1M1	5140	0.065	0.5	NO
74	AGA	AGA	AGA	5212	0.064	0.5	NO
75	GGA3	GGA3	GGA3	5537	0.056	0.48	NO
76	CLTB	CLTB	CLTB	5561	0.055	0.48	NO
77	ATP6V0A2	ATP6V0A2	ATP6V0A2	5606	0.054	0.48	NO
78	IGF2R	IGF2R	IGF2R	5641	0.053	0.48	NO
79	CD164	CD164	CD164	5901	0.046	0.47	NO
80	AP4B1	AP4B1	AP4B1	6072	0.043	0.46	NO
81	AP1S2	AP1S2	AP1S2	6371	0.036	0.45	NO
82	CLN5	CLN5	CLN5	6492	0.034	0.44	NO
83	CLTC	CLTC	CLTC	6613	0.031	0.44	NO
84	SCARB2	SCARB2	SCARB2	6785	0.028	0.43	NO
85	PPT1	PPT1	PPT1	6802	0.028	0.43	NO
86	AP3B1	AP3B1	AP3B1	7080	0.021	0.42	NO
87	GGA2	GGA2	GGA2	7136	0.02	0.42	NO
88	GGA1	GGA1	GGA1	7491	0.012	0.4	NO
89	NPC1	NPC1	NPC1	7625	0.0095	0.39	NO
90	IDS	IDS	IDS	7747	0.0068	0.38	NO
91	AP1G1	AP1G1	AP1G1	7952	0.0027	0.37	NO
92	AP4E1	AP4E1	AP4E1	8506	-0.0087	0.34	NO
93	AP3M1	AP3M1	AP3M1	8562	-0.01	0.34	NO
94	CLTCL1	CLTCL1	CLTCL1	8737	-0.014	0.33	NO
95	AP3D1	AP3D1	AP3D1	8741	-0.014	0.33	NO
96	ATP6V0A1	ATP6V0A1	ATP6V0A1	9225	-0.024	0.31	NO
97	AP1S3	AP1S3	AP1S3	9233	-0.025	0.31	NO
98	AP3S2	AP3S2	AP3S2	9286	-0.026	0.31	NO
99	AP4M1	AP4M1	AP4M1	9793	-0.036	0.28	NO
100	PPT2	PPT2	PPT2	9955	-0.04	0.27	NO
101	SLC11A2	SLC11A2	SLC11A2	10386	-0.048	0.25	NO
102	CTSK	CTSK	CTSK	10588	-0.052	0.24	NO
103	MFSD8	MFSD8	MFSD8	10710	-0.055	0.24	NO
104	ENTPD4	ENTPD4	ENTPD4	10725	-0.055	0.24	NO
105	AP4S1	AP4S1	AP4S1	11022	-0.062	0.23	NO
106	CTSE	CTSE	CTSE	11157	-0.064	0.23	NO
107	LAPTM4B	LAPTM4B	LAPTM4B	11289	-0.068	0.22	NO
108	ATP6V1H	ATP6V1H	ATP6V1H	11494	-0.073	0.22	NO
109	AP3M2	AP3M2	AP3M2	11527	-0.073	0.22	NO
110	ARSG	ARSG	ARSG	11997	-0.085	0.2	NO
111	ARSB	ARSB	ARSB	12562	-0.1	0.17	NO
112	CTSF	CTSF	CTSF	13319	-0.13	0.14	NO
113	ABCA2	ABCA2	ABCA2	14054	-0.16	0.1	NO
114	AP1M2	AP1M2	AP1M2	15058	-0.21	0.06	NO
115	ABCB9	ABCB9	ABCB9	15489	-0.23	0.05	NO
116	ATP6V0A4	ATP6V0A4	ATP6V0A4	15831	-0.26	0.045	NO
117	SORT1	SORT1	SORT1	16408	-0.31	0.03	NO
118	AP3B2	AP3B2	AP3B2	17619	-0.51	-0.0084	NO
119	CTSL2	CTSL2	CTSL2	18028	-0.69	0.0076	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NCF1	NCF1	NCF1	31	0.77	0.039	YES
2	VAV1	VAV1	VAV1	42	0.75	0.078	YES
3	FCGR1A	FCGR1A	FCGR1A	56	0.73	0.12	YES
4	HCK	HCK	HCK	88	0.68	0.15	YES
5	WAS	WAS	WAS	104	0.66	0.18	YES
6	PIK3R5	PIK3R5	PIK3R5	244	0.57	0.2	YES
7	FCGR2B	FCGR2B	FCGR2B	256	0.57	0.23	YES
8	FCGR2C	FCGR2C	FCGR2C	273	0.56	0.26	YES
9	SYK	SYK	SYK	326	0.53	0.29	YES
10	DOCK2	DOCK2	DOCK2	334	0.53	0.32	YES
11	FCGR3A	FCGR3A	FCGR3A	338	0.53	0.34	YES
12	RAC2	RAC2	RAC2	376	0.51	0.37	YES
13	PIK3CG	PIK3CG	PIK3CG	417	0.5	0.39	YES
14	PTPRC	PTPRC	PTPRC	501	0.47	0.41	YES
15	FCGR2A	FCGR2A	FCGR2A	516	0.47	0.44	YES
16	INPP5D	INPP5D	INPP5D	655	0.42	0.45	YES
17	PIK3CD	PIK3CD	PIK3CD	659	0.42	0.47	YES
18	ASAP3	ASAP3	ASAP3	746	0.4	0.49	YES
19	LYN	LYN	LYN	907	0.36	0.5	YES
20	DNM1	DNM1	DNM1	952	0.35	0.51	YES
21	LIMK1	LIMK1	LIMK1	1342	0.28	0.51	YES
22	ARPC1B	ARPC1B	ARPC1B	1366	0.28	0.52	YES
23	SCIN	SCIN	SCIN	1390	0.28	0.53	YES
24	SPHK1	SPHK1	SPHK1	1452	0.27	0.55	YES
25	PLCG2	PLCG2	PLCG2	1530	0.26	0.55	YES
26	PRKCB	PRKCB	PRKCB	1582	0.25	0.56	YES
27	LAT	LAT	LAT	1626	0.25	0.57	YES
28	MARCKS	MARCKS	MARCKS	1686	0.24	0.58	YES
29	PLA2G4A	PLA2G4A	PLA2G4A	2168	0.19	0.57	NO
30	ARPC3	ARPC3	ARPC3	2700	0.16	0.55	NO
31	PPAP2B	PPAP2B	PPAP2B	3285	0.12	0.52	NO
32	ARPC5L	ARPC5L	ARPC5L	3566	0.11	0.51	NO
33	CDC42	CDC42	CDC42	3833	0.1	0.5	NO
34	ARF6	ARF6	ARF6	3841	0.1	0.51	NO
35	ARPC4	ARPC4	ARPC4	4169	0.094	0.49	NO
36	CFL1	CFL1	CFL1	4263	0.091	0.49	NO
37	MAPK3	MAPK3	MAPK3	4459	0.084	0.49	NO
38	ARPC2	ARPC2	ARPC2	4754	0.075	0.48	NO
39	RAC1	RAC1	RAC1	5179	0.065	0.46	NO
40	DNM2	DNM2	DNM2	5458	0.057	0.44	NO
41	PLD2	PLD2	PLD2	5460	0.057	0.45	NO
42	ARPC5	ARPC5	ARPC5	5628	0.053	0.44	NO
43	SPHK2	SPHK2	SPHK2	5648	0.053	0.44	NO
44	PAK1	PAK1	PAK1	5692	0.051	0.44	NO
45	PRKCD	PRKCD	PRKCD	5860	0.047	0.43	NO
46	MAP2K1	MAP2K1	MAP2K1	6110	0.042	0.42	NO
47	VAV3	VAV3	VAV3	6196	0.04	0.42	NO
48	PRKCA	PRKCA	PRKCA	6584	0.032	0.4	NO
49	ARPC1A	ARPC1A	ARPC1A	6868	0.026	0.39	NO
50	CRK	CRK	CRK	7079	0.021	0.38	NO
51	PIK3R2	PIK3R2	PIK3R2	7145	0.02	0.37	NO
52	PLD1	PLD1	PLD1	7197	0.019	0.37	NO
53	ASAP2	ASAP2	ASAP2	7249	0.017	0.37	NO
54	WASF3	WASF3	WASF3	7516	0.012	0.36	NO
55	ASAP1	ASAP1	ASAP1	7701	0.008	0.34	NO
56	CRKL	CRKL	CRKL	8106	-0.00068	0.32	NO
57	WASL	WASL	WASL	8444	-0.0072	0.3	NO
58	AKT2	AKT2	AKT2	8698	-0.013	0.29	NO
59	PRKCE	PRKCE	PRKCE	8749	-0.014	0.29	NO
60	AKT1	AKT1	AKT1	8752	-0.014	0.29	NO
61	MAPK1	MAPK1	MAPK1	8903	-0.017	0.28	NO
62	WASF2	WASF2	WASF2	8963	-0.018	0.28	NO
63	RPS6KB1	RPS6KB1	RPS6KB1	9111	-0.022	0.27	NO
64	PIP5K1C	PIP5K1C	PIP5K1C	9327	-0.027	0.26	NO
65	RAF1	RAF1	RAF1	9549	-0.031	0.25	NO
66	VASP	VASP	VASP	9676	-0.034	0.25	NO
67	GSN	GSN	GSN	9866	-0.037	0.24	NO
68	VAV2	VAV2	VAV2	9973	-0.04	0.24	NO
69	PIK3CB	PIK3CB	PIK3CB	10508	-0.051	0.21	NO
70	PIK3CA	PIK3CA	PIK3CA	10819	-0.057	0.19	NO
71	LIMK2	LIMK2	LIMK2	11273	-0.067	0.17	NO
72	GAB2	GAB2	GAB2	11292	-0.068	0.18	NO
73	MYO10	MYO10	MYO10	11690	-0.077	0.16	NO
74	PPAP2A	PPAP2A	PPAP2A	11903	-0.082	0.15	NO
75	PLCG1	PLCG1	PLCG1	12187	-0.091	0.14	NO
76	PIP4K2B	PIP4K2B	PIP4K2B	12303	-0.094	0.14	NO
77	DNM1L	DNM1L	DNM1L	12749	-0.11	0.12	NO
78	PIP5K1A	PIP5K1A	PIP5K1A	12997	-0.12	0.11	NO
79	MARCKSL1	MARCKSL1	MARCKSL1	13066	-0.12	0.11	NO
80	PIKFYVE	PIKFYVE	PIKFYVE	13159	-0.12	0.12	NO
81	PIK3R1	PIK3R1	PIK3R1	13698	-0.14	0.092	NO
82	PIK3R3	PIK3R3	PIK3R3	14093	-0.16	0.079	NO
83	PLA2G6	PLA2G6	PLA2G6	14338	-0.17	0.074	NO
84	AMPH	AMPH	AMPH	14391	-0.17	0.08	NO
85	WASF1	WASF1	WASF1	14774	-0.19	0.069	NO
86	PLA2G4F	PLA2G4F	PLA2G4F	15095	-0.21	0.062	NO
87	PLA2G4D	PLA2G4D	PLA2G4D	15364	-0.22	0.059	NO
88	CFL2	CFL2	CFL2	15421	-0.23	0.068	NO
89	PRKCG	PRKCG	PRKCG	16098	-0.28	0.046	NO
90	AKT3	AKT3	AKT3	16327	-0.3	0.049	NO
91	PPAP2C	PPAP2C	PPAP2C	16331	-0.3	0.064	NO
92	DNM3	DNM3	DNM3	16337	-0.3	0.08	NO
93	PIP5K1B	PIP5K1B	PIP5K1B	17161	-0.4	0.056	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAV1	VAV1	VAV1	42	0.75	0.16	YES
2	BTK	BTK	BTK	152	0.62	0.28	YES
3	SYK	SYK	SYK	326	0.53	0.39	YES
4	LYN	LYN	LYN	907	0.36	0.43	YES
5	CD79A	CD79A	CD79A	1078	0.32	0.49	YES
6	CD79B	CD79B	CD79B	1382	0.28	0.54	YES
7	PRKCB	PRKCB	PRKCB	1582	0.25	0.58	YES
8	BLNK	BLNK	BLNK	1587	0.25	0.63	YES
9	MAP3K1	MAP3K1	MAP3K1	2838	0.15	0.6	NO
10	GRB2	GRB2	GRB2	4278	0.09	0.54	NO
11	PPP3CC	PPP3CC	PPP3CC	4386	0.086	0.55	NO
12	MAPK3	MAPK3	MAPK3	4459	0.084	0.56	NO
13	RAC1	RAC1	RAC1	5179	0.065	0.54	NO
14	MAP2K1	MAP2K1	MAP2K1	6110	0.042	0.49	NO
15	NFATC1	NFATC1	NFATC1	6467	0.034	0.48	NO
16	PRKCA	PRKCA	PRKCA	6584	0.032	0.48	NO
17	CALM3	CALM3	CALM3	7060	0.022	0.46	NO
18	CALM2	CALM2	CALM2	7144	0.02	0.46	NO
19	MAPK14	MAPK14	MAPK14	7421	0.014	0.45	NO
20	NFATC3	NFATC3	NFATC3	7528	0.012	0.44	NO
21	PPP3CA	PPP3CA	PPP3CA	8190	-0.0024	0.41	NO
22	NFATC2	NFATC2	NFATC2	8283	-0.0042	0.4	NO
23	FOS	FOS	FOS	8297	-0.0043	0.4	NO
24	ELK1	ELK1	ELK1	8364	-0.006	0.4	NO
25	JUN	JUN	JUN	8616	-0.012	0.39	NO
26	PPP3CB	PPP3CB	PPP3CB	8715	-0.014	0.39	NO
27	RAF1	RAF1	RAF1	9549	-0.031	0.35	NO
28	CALM1	CALM1	CALM1	9995	-0.04	0.33	NO
29	SHC1	SHC1	SHC1	11470	-0.072	0.27	NO
30	MAPK8	MAPK8	MAPK8	11620	-0.075	0.28	NO
31	PLCG1	PLCG1	PLCG1	12187	-0.091	0.26	NO
32	SOS1	SOS1	SOS1	12396	-0.097	0.27	NO
33	NFATC4	NFATC4	NFATC4	15180	-0.21	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL18	IL18	IL18	58	0.73	0.079	YES
2	AIM2	AIM2	AIM2	72	0.7	0.16	YES
3	CCL4	CCL4	CCL4	86	0.68	0.23	YES
4	RIPK3	RIPK3	RIPK3	153	0.62	0.3	YES
5	CCL4L2	CCL4L2	CCL4L2	254	0.57	0.36	YES
6	CCL5	CCL5	CCL5	337	0.53	0.41	YES
7	POLR3G	POLR3G	POLR3G	421	0.5	0.46	YES
8	CXCL10	CXCL10	CXCL10	426	0.5	0.52	YES
9	ZBP1	ZBP1	ZBP1	618	0.44	0.56	YES
10	CASP1	CASP1	CASP1	723	0.41	0.6	YES
11	IL6	IL6	IL6	757	0.4	0.64	YES
12	PYCARD	PYCARD	PYCARD	1091	0.32	0.66	YES
13	IL1B	IL1B	IL1B	1216	0.3	0.68	YES
14	IKBKE	IKBKE	IKBKE	1491	0.26	0.7	YES
15	IRF7	IRF7	IRF7	1707	0.24	0.71	YES
16	NFKBIB	NFKBIB	NFKBIB	2971	0.14	0.66	NO
17	TREX1	TREX1	TREX1	3058	0.14	0.67	NO
18	IKBKG	IKBKG	IKBKG	3123	0.13	0.68	NO
19	NFKBIA	NFKBIA	NFKBIA	3444	0.12	0.68	NO
20	POLR1C	POLR1C	POLR1C	3458	0.12	0.69	NO
21	IRF3	IRF3	IRF3	4158	0.094	0.66	NO
22	POLR3K	POLR3K	POLR3K	4404	0.086	0.66	NO
23	POLR3H	POLR3H	POLR3H	4504	0.083	0.66	NO
24	NFKB1	NFKB1	NFKB1	4559	0.081	0.66	NO
25	IFNB1	IFNB1	IFNB1	4586	0.08	0.67	NO
26	TMEM173	TMEM173	TMEM173	4784	0.075	0.67	NO
27	POLR3D	POLR3D	POLR3D	4863	0.072	0.67	NO
28	POLR3B	POLR3B	POLR3B	5060	0.067	0.67	NO
29	POLR3GL	POLR3GL	POLR3GL	5597	0.054	0.65	NO
30	POLR3C	POLR3C	POLR3C	5707	0.051	0.65	NO
31	RIPK1	RIPK1	RIPK1	6377	0.036	0.61	NO
32	CHUK	CHUK	CHUK	6570	0.032	0.61	NO
33	RELA	RELA	RELA	7670	0.0085	0.55	NO
34	TBK1	TBK1	TBK1	7869	0.0044	0.54	NO
35	POLR3A	POLR3A	POLR3A	8172	-0.002	0.52	NO
36	DDX58	DDX58	DDX58	8521	-0.009	0.5	NO
37	POLR1D	POLR1D	POLR1D	8925	-0.018	0.48	NO
38	ADAR	ADAR	ADAR	8981	-0.019	0.48	NO
39	MAVS	MAVS	MAVS	9560	-0.031	0.45	NO
40	IKBKB	IKBKB	IKBKB	9776	-0.036	0.44	NO
41	IL33	IL33	IL33	11798	-0.08	0.34	NO
42	POLR3F	POLR3F	POLR3F	11885	-0.082	0.35	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAV1	VAV1	VAV1	42	0.75	0.047	YES
2	LILRB3	LILRB3	LILRB3	73	0.7	0.092	YES
3	BTK	BTK	BTK	152	0.62	0.13	YES
4	PIK3AP1	PIK3AP1	PIK3AP1	170	0.61	0.17	YES
5	PTPN6	PTPN6	PTPN6	238	0.57	0.2	YES
6	PIK3R5	PIK3R5	PIK3R5	244	0.57	0.24	YES
7	FCGR2B	FCGR2B	FCGR2B	256	0.57	0.28	YES
8	CD72	CD72	CD72	276	0.56	0.31	YES
9	SYK	SYK	SYK	326	0.53	0.35	YES
10	RAC2	RAC2	RAC2	376	0.51	0.38	YES
11	DAPP1	DAPP1	DAPP1	416	0.5	0.41	YES
12	PIK3CG	PIK3CG	PIK3CG	417	0.5	0.44	YES
13	INPP5D	INPP5D	INPP5D	655	0.42	0.46	YES
14	PIK3CD	PIK3CD	PIK3CD	659	0.42	0.48	YES
15	CARD11	CARD11	CARD11	667	0.42	0.51	YES
16	CD19	CD19	CD19	742	0.4	0.54	YES
17	LYN	LYN	LYN	907	0.36	0.55	YES
18	NFKBIE	NFKBIE	NFKBIE	981	0.34	0.57	YES
19	CD79A	CD79A	CD79A	1078	0.32	0.58	YES
20	CR2	CR2	CR2	1122	0.32	0.6	YES
21	CD79B	CD79B	CD79B	1382	0.28	0.61	YES
22	PLCG2	PLCG2	PLCG2	1530	0.26	0.62	YES
23	PRKCB	PRKCB	PRKCB	1582	0.25	0.63	YES
24	BLNK	BLNK	BLNK	1587	0.25	0.65	YES
25	IFITM1	IFITM1	IFITM1	1772	0.23	0.65	YES
26	RASGRP3	RASGRP3	RASGRP3	1861	0.22	0.66	YES
27	BCL10	BCL10	BCL10	2509	0.17	0.64	NO
28	NFKBIB	NFKBIB	NFKBIB	2971	0.14	0.62	NO
29	IKBKG	IKBKG	IKBKG	3123	0.13	0.62	NO
30	NRAS	NRAS	NRAS	3294	0.12	0.62	NO
31	NFKBIA	NFKBIA	NFKBIA	3444	0.12	0.62	NO
32	CHP	CHP	CHP	3832	0.1	0.6	NO
33	MAP2K2	MAP2K2	MAP2K2	3855	0.1	0.61	NO
34	GRB2	GRB2	GRB2	4278	0.09	0.59	NO
35	CD22	CD22	CD22	4347	0.088	0.6	NO
36	PPP3CC	PPP3CC	PPP3CC	4386	0.086	0.6	NO
37	MAPK3	MAPK3	MAPK3	4459	0.084	0.6	NO
38	NFKB1	NFKB1	NFKB1	4559	0.081	0.6	NO
39	RAC1	RAC1	RAC1	5179	0.065	0.57	NO
40	MAP2K1	MAP2K1	MAP2K1	6110	0.042	0.52	NO
41	VAV3	VAV3	VAV3	6196	0.04	0.52	NO
42	CD81	CD81	CD81	6296	0.038	0.52	NO
43	NFATC1	NFATC1	NFATC1	6467	0.034	0.51	NO
44	CHUK	CHUK	CHUK	6570	0.032	0.51	NO
45	PIK3R2	PIK3R2	PIK3R2	7145	0.02	0.48	NO
46	KRAS	KRAS	KRAS	7424	0.014	0.46	NO
47	NFATC3	NFATC3	NFATC3	7528	0.012	0.46	NO
48	RELA	RELA	RELA	7670	0.0085	0.45	NO
49	PPP3CA	PPP3CA	PPP3CA	8190	-0.0024	0.42	NO
50	NFATC2	NFATC2	NFATC2	8283	-0.0042	0.42	NO
51	FOS	FOS	FOS	8297	-0.0043	0.42	NO
52	MALT1	MALT1	MALT1	8522	-0.009	0.4	NO
53	JUN	JUN	JUN	8616	-0.012	0.4	NO
54	AKT2	AKT2	AKT2	8698	-0.013	0.4	NO
55	PPP3CB	PPP3CB	PPP3CB	8715	-0.014	0.4	NO
56	AKT1	AKT1	AKT1	8752	-0.014	0.4	NO
57	MAPK1	MAPK1	MAPK1	8903	-0.017	0.39	NO
58	RAF1	RAF1	RAF1	9549	-0.031	0.35	NO
59	PPP3R1	PPP3R1	PPP3R1	9603	-0.032	0.35	NO
60	PPP3R2	PPP3R2	PPP3R2	9648	-0.033	0.35	NO
61	IKBKB	IKBKB	IKBKB	9776	-0.036	0.35	NO
62	VAV2	VAV2	VAV2	9973	-0.04	0.34	NO
63	PIK3CB	PIK3CB	PIK3CB	10508	-0.051	0.31	NO
64	PIK3CA	PIK3CA	PIK3CA	10819	-0.057	0.3	NO
65	GSK3B	GSK3B	GSK3B	11665	-0.076	0.26	NO
66	NFAT5	NFAT5	NFAT5	12285	-0.094	0.23	NO
67	SOS1	SOS1	SOS1	12396	-0.097	0.23	NO
68	SOS2	SOS2	SOS2	12538	-0.1	0.23	NO
69	PIK3R1	PIK3R1	PIK3R1	13698	-0.14	0.18	NO
70	PIK3R3	PIK3R3	PIK3R3	14093	-0.16	0.16	NO
71	RAC3	RAC3	RAC3	14430	-0.17	0.16	NO
72	NFATC4	NFATC4	NFATC4	15180	-0.21	0.13	NO
73	CHP2	CHP2	CHP2	15394	-0.23	0.13	NO
74	AKT3	AKT3	AKT3	16327	-0.3	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAV1	VAV1	VAV1	42	0.75	0.022	YES
2	FCER1G	FCER1G	FCER1G	102	0.66	0.041	YES
3	HCST	HCST	HCST	108	0.65	0.062	YES
4	PRF1	PRF1	PRF1	128	0.64	0.082	YES
5	SH2D1A	SH2D1A	SH2D1A	208	0.59	0.098	YES
6	PTPN6	PTPN6	PTPN6	238	0.57	0.12	YES
7	PIK3R5	PIK3R5	PIK3R5	244	0.57	0.13	YES
8	KLRC1	KLRC1	KLRC1	245	0.57	0.15	YES
9	TYROBP	TYROBP	TYROBP	247	0.57	0.17	YES
10	KLRD1	KLRD1	KLRD1	302	0.54	0.19	YES
11	SYK	SYK	SYK	326	0.53	0.2	YES
12	FCGR3A	FCGR3A	FCGR3A	338	0.53	0.22	YES
13	ITGB2	ITGB2	ITGB2	339	0.53	0.24	YES
14	NCR3	NCR3	NCR3	361	0.52	0.25	YES
15	LCP2	LCP2	LCP2	363	0.52	0.27	YES
16	LCK	LCK	LCK	371	0.52	0.29	YES
17	GZMB	GZMB	GZMB	372	0.52	0.3	YES
18	KIR2DL4	KIR2DL4	KIR2DL4	373	0.52	0.32	YES
19	RAC2	RAC2	RAC2	376	0.51	0.34	YES
20	ITGAL	ITGAL	ITGAL	403	0.5	0.35	YES
21	CD247	CD247	CD247	404	0.5	0.37	YES
22	PIK3CG	PIK3CG	PIK3CG	417	0.5	0.39	YES
23	ULBP2	ULBP2	ULBP2	433	0.49	0.4	YES
24	FASLG	FASLG	FASLG	444	0.49	0.42	YES
25	KLRK1	KLRK1	KLRK1	479	0.48	0.43	YES
26	CD48	CD48	CD48	542	0.46	0.44	YES
27	TNFRSF10C	TNFRSF10C	TNFRSF10C	544	0.46	0.46	YES
28	TNFSF10	TNFSF10	TNFSF10	624	0.43	0.47	YES
29	SH2D1B	SH2D1B	SH2D1B	626	0.43	0.48	YES
30	PIK3CD	PIK3CD	PIK3CD	659	0.42	0.49	YES
31	KLRC2	KLRC2	KLRC2	675	0.42	0.51	YES
32	KLRC3	KLRC3	KLRC3	704	0.41	0.52	YES
33	ICAM1	ICAM1	ICAM1	714	0.41	0.53	YES
34	ZAP70	ZAP70	ZAP70	719	0.41	0.55	YES
35	IFNG	IFNG	IFNG	842	0.37	0.55	YES
36	KIR3DL2	KIR3DL2	KIR3DL2	844	0.37	0.56	YES
37	RAET1G	RAET1G	RAET1G	918	0.35	0.57	YES
38	NCR1	NCR1	NCR1	943	0.35	0.58	YES
39	KIR2DL3	KIR2DL3	KIR2DL3	1004	0.34	0.59	YES
40	CSF2	CSF2	CSF2	1042	0.33	0.6	YES
41	ULBP1	ULBP1	ULBP1	1061	0.32	0.61	YES
42	CD244	CD244	CD244	1100	0.32	0.62	YES
43	KIR2DS4	KIR2DS4	KIR2DS4	1106	0.32	0.63	YES
44	FCGR3B	FCGR3B	FCGR3B	1202	0.3	0.63	YES
45	FYN	FYN	FYN	1282	0.29	0.64	YES
46	BID	BID	BID	1325	0.28	0.64	YES
47	ICAM2	ICAM2	ICAM2	1338	0.28	0.65	YES
48	TNF	TNF	TNF	1356	0.28	0.66	YES
49	HLA-G	HLA-G	HLA-G	1420	0.27	0.67	YES
50	KIR2DL1	KIR2DL1	KIR2DL1	1436	0.27	0.67	YES
51	PLCG2	PLCG2	PLCG2	1530	0.26	0.68	YES
52	KIR3DL1	KIR3DL1	KIR3DL1	1539	0.26	0.68	YES
53	PRKCB	PRKCB	PRKCB	1582	0.25	0.69	YES
54	RAET1E	RAET1E	RAET1E	1621	0.25	0.7	YES
55	LAT	LAT	LAT	1626	0.25	0.7	YES
56	TNFRSF10A	TNFRSF10A	TNFRSF10A	1719	0.24	0.71	YES
57	HLA-B	HLA-B	HLA-B	1805	0.23	0.71	YES
58	HLA-E	HLA-E	HLA-E	1977	0.21	0.71	YES
59	IFNGR1	IFNGR1	IFNGR1	2221	0.19	0.7	YES
60	IFNGR2	IFNGR2	IFNGR2	2250	0.18	0.71	YES
61	HLA-C	HLA-C	HLA-C	2274	0.18	0.71	YES
62	ULBP3	ULBP3	ULBP3	2339	0.18	0.71	YES
63	HLA-A	HLA-A	HLA-A	2428	0.17	0.71	YES
64	NRAS	NRAS	NRAS	3294	0.12	0.67	NO
65	CHP	CHP	CHP	3832	0.1	0.64	NO
66	MAP2K2	MAP2K2	MAP2K2	3855	0.1	0.65	NO
67	IFNAR2	IFNAR2	IFNAR2	3965	0.1	0.64	NO
68	MICA	MICA	MICA	4070	0.097	0.64	NO
69	IFNAR1	IFNAR1	IFNAR1	4219	0.092	0.64	NO
70	GRB2	GRB2	GRB2	4278	0.09	0.64	NO
71	PPP3CC	PPP3CC	PPP3CC	4386	0.086	0.63	NO
72	MAPK3	MAPK3	MAPK3	4459	0.084	0.63	NO
73	SHC3	SHC3	SHC3	4489	0.083	0.63	NO
74	IFNB1	IFNB1	IFNB1	4586	0.08	0.63	NO
75	TNFRSF10B	TNFRSF10B	TNFRSF10B	4686	0.077	0.63	NO
76	CASP3	CASP3	CASP3	4794	0.074	0.62	NO
77	ARAF	ARAF	ARAF	4797	0.074	0.62	NO
78	FAS	FAS	FAS	4995	0.069	0.62	NO
79	RAC1	RAC1	RAC1	5179	0.065	0.61	NO
80	SH3BP2	SH3BP2	SH3BP2	5411	0.058	0.6	NO
81	HRAS	HRAS	HRAS	5457	0.057	0.6	NO
82	PAK1	PAK1	PAK1	5692	0.051	0.59	NO
83	PTK2B	PTK2B	PTK2B	5705	0.051	0.59	NO
84	MAP2K1	MAP2K1	MAP2K1	6110	0.042	0.57	NO
85	TNFRSF10D	TNFRSF10D	TNFRSF10D	6129	0.042	0.57	NO
86	VAV3	VAV3	VAV3	6196	0.04	0.56	NO
87	NFATC1	NFATC1	NFATC1	6467	0.034	0.55	NO
88	PRKCA	PRKCA	PRKCA	6584	0.032	0.55	NO
89	PIK3R2	PIK3R2	PIK3R2	7145	0.02	0.52	NO
90	KRAS	KRAS	KRAS	7424	0.014	0.5	NO
91	NFATC3	NFATC3	NFATC3	7528	0.012	0.49	NO
92	PPP3CA	PPP3CA	PPP3CA	8190	-0.0024	0.46	NO
93	NFATC2	NFATC2	NFATC2	8283	-0.0042	0.45	NO
94	PPP3CB	PPP3CB	PPP3CB	8715	-0.014	0.43	NO
95	MAPK1	MAPK1	MAPK1	8903	-0.017	0.42	NO
96	RAET1L	RAET1L	RAET1L	9186	-0.024	0.4	NO
97	RAF1	RAF1	RAF1	9549	-0.031	0.39	NO
98	PPP3R1	PPP3R1	PPP3R1	9603	-0.032	0.38	NO
99	PPP3R2	PPP3R2	PPP3R2	9648	-0.033	0.38	NO
100	VAV2	VAV2	VAV2	9973	-0.04	0.37	NO
101	PIK3CB	PIK3CB	PIK3CB	10508	-0.051	0.34	NO
102	PIK3CA	PIK3CA	PIK3CA	10819	-0.057	0.32	NO
103	PTPN11	PTPN11	PTPN11	11128	-0.064	0.31	NO
104	BRAF	BRAF	BRAF	11330	-0.068	0.3	NO
105	SHC1	SHC1	SHC1	11470	-0.072	0.29	NO
106	PLCG1	PLCG1	PLCG1	12187	-0.091	0.26	NO
107	NFAT5	NFAT5	NFAT5	12285	-0.094	0.26	NO
108	SOS1	SOS1	SOS1	12396	-0.097	0.25	NO
109	SOS2	SOS2	SOS2	12538	-0.1	0.25	NO
110	PIK3R1	PIK3R1	PIK3R1	13698	-0.14	0.19	NO
111	PIK3R3	PIK3R3	PIK3R3	14093	-0.16	0.17	NO
112	RAC3	RAC3	RAC3	14430	-0.17	0.16	NO
113	NFATC4	NFATC4	NFATC4	15180	-0.21	0.12	NO
114	CHP2	CHP2	CHP2	15394	-0.23	0.12	NO
115	PRKCG	PRKCG	PRKCG	16098	-0.28	0.09	NO
116	SHC2	SHC2	SHC2	16837	-0.35	0.061	NO
117	SHC4	SHC4	SHC4	17074	-0.39	0.06	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAV1	VAV1	VAV1	42	0.75	0.1	YES
2	PTPN7	PTPN7	PTPN7	214	0.58	0.17	YES
3	LCK	LCK	LCK	371	0.52	0.24	YES
4	CD3D	CD3D	CD3D	380	0.51	0.31	YES
5	CD247	CD247	CD247	404	0.5	0.38	YES
6	PIK3CG	PIK3CG	PIK3CG	417	0.5	0.44	YES
7	CD3E	CD3E	CD3E	512	0.47	0.5	YES
8	ZAP70	ZAP70	ZAP70	719	0.41	0.55	YES
9	CD3G	CD3G	CD3G	744	0.4	0.6	YES
10	FYN	FYN	FYN	1282	0.29	0.61	YES
11	PRKCB	PRKCB	PRKCB	1582	0.25	0.63	YES
12	LAT	LAT	LAT	1626	0.25	0.66	YES
13	MAP3K1	MAP3K1	MAP3K1	2838	0.15	0.62	NO
14	NFKBIA	NFKBIA	NFKBIA	3444	0.12	0.6	NO
15	GRB2	GRB2	GRB2	4278	0.09	0.57	NO
16	PPP3CC	PPP3CC	PPP3CC	4386	0.086	0.57	NO
17	MAPK3	MAPK3	MAPK3	4459	0.084	0.58	NO
18	NFKB1	NFKB1	NFKB1	4559	0.081	0.59	NO
19	RAC1	RAC1	RAC1	5179	0.065	0.56	NO
20	MAP2K1	MAP2K1	MAP2K1	6110	0.042	0.52	NO
21	NFATC1	NFATC1	NFATC1	6467	0.034	0.5	NO
22	PRKCA	PRKCA	PRKCA	6584	0.032	0.5	NO
23	CALM3	CALM3	CALM3	7060	0.022	0.48	NO
24	CALM2	CALM2	CALM2	7144	0.02	0.47	NO
25	RASA1	RASA1	RASA1	7240	0.018	0.47	NO
26	NFATC3	NFATC3	NFATC3	7528	0.012	0.46	NO
27	RELA	RELA	RELA	7670	0.0085	0.45	NO
28	PPP3CA	PPP3CA	PPP3CA	8190	-0.0024	0.42	NO
29	NFATC2	NFATC2	NFATC2	8283	-0.0042	0.42	NO
30	FOS	FOS	FOS	8297	-0.0043	0.42	NO
31	ELK1	ELK1	ELK1	8364	-0.006	0.42	NO
32	JUN	JUN	JUN	8616	-0.012	0.4	NO
33	PPP3CB	PPP3CB	PPP3CB	8715	-0.014	0.4	NO
34	RAF1	RAF1	RAF1	9549	-0.031	0.36	NO
35	CALM1	CALM1	CALM1	9995	-0.04	0.34	NO
36	PIK3CA	PIK3CA	PIK3CA	10819	-0.057	0.3	NO
37	MAP2K4	MAP2K4	MAP2K4	10976	-0.061	0.3	NO
38	SHC1	SHC1	SHC1	11470	-0.072	0.28	NO
39	MAPK8	MAPK8	MAPK8	11620	-0.075	0.29	NO
40	PLCG1	PLCG1	PLCG1	12187	-0.091	0.27	NO
41	SOS1	SOS1	SOS1	12396	-0.097	0.27	NO
42	PIK3R1	PIK3R1	PIK3R1	13698	-0.14	0.22	NO
43	NFATC4	NFATC4	NFATC4	15180	-0.21	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FASLG	FASLG	FASLG	444	0.49	0.13	YES
2	CASP10	CASP10	CASP10	906	0.36	0.22	YES
3	RIPK2	RIPK2	RIPK2	1801	0.23	0.25	YES
4	RB1	RB1	RB1	2061	0.2	0.3	YES
5	ARHGDIB	ARHGDIB	ARHGDIB	2242	0.18	0.35	YES
6	FADD	FADD	FADD	2461	0.17	0.39	YES
7	MAP3K1	MAP3K1	MAP3K1	2838	0.15	0.42	YES
8	DFFB	DFFB	DFFB	3670	0.11	0.41	YES
9	CASP7	CASP7	CASP7	3744	0.11	0.44	YES
10	LMNB2	LMNB2	LMNB2	4671	0.077	0.42	YES
11	CASP3	CASP3	CASP3	4794	0.074	0.43	YES
12	CFLAR	CFLAR	CFLAR	4936	0.07	0.45	YES
13	FAS	FAS	FAS	4995	0.069	0.47	YES
14	DAXX	DAXX	DAXX	5455	0.058	0.46	YES
15	CASP8	CASP8	CASP8	5488	0.057	0.48	YES
16	LMNA	LMNA	LMNA	5495	0.057	0.5	YES
17	DFFA	DFFA	DFFA	5577	0.054	0.51	YES
18	PAK1	PAK1	PAK1	5692	0.051	0.52	YES
19	PAK2	PAK2	PAK2	5712	0.051	0.53	YES
20	SPTAN1	SPTAN1	SPTAN1	7981	0.002	0.41	NO
21	JUN	JUN	JUN	8616	-0.012	0.38	NO
22	FAF1	FAF1	FAF1	8900	-0.017	0.37	NO
23	PTPN13	PTPN13	PTPN13	9226	-0.024	0.36	NO
24	MAP3K7	MAP3K7	MAP3K7	9735	-0.035	0.34	NO
25	MAP2K4	MAP2K4	MAP2K4	10976	-0.061	0.29	NO
26	CASP6	CASP6	CASP6	11212	-0.066	0.3	NO
27	MAPK8	MAPK8	MAPK8	11620	-0.075	0.3	NO
28	PARP1	PARP1	PARP1	11823	-0.08	0.32	NO
29	PRKDC	PRKDC	PRKDC	12344	-0.095	0.32	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD14	CD14	CD14	190	0.6	0.11	YES
2	TLR7	TLR7	TLR7	414	0.5	0.19	YES
3	LY96	LY96	LY96	498	0.47	0.28	YES
4	TLR4	TLR4	TLR4	509	0.47	0.37	YES
5	TLR2	TLR2	TLR2	521	0.47	0.46	YES
6	TLR6	TLR6	TLR6	565	0.45	0.55	YES
7	TLR10	TLR10	TLR10	1425	0.27	0.56	YES
8	MYD88	MYD88	MYD88	2282	0.18	0.54	YES
9	IRAK1	IRAK1	IRAK1	2750	0.15	0.55	YES
10	MAP3K1	MAP3K1	MAP3K1	2838	0.15	0.57	YES
11	MAP2K3	MAP2K3	MAP2K3	3028	0.14	0.59	YES
12	IKBKG	IKBKG	IKBKG	3123	0.13	0.61	YES
13	NFKBIA	NFKBIA	NFKBIA	3444	0.12	0.62	YES
14	MAP2K6	MAP2K6	MAP2K6	4033	0.098	0.6	NO
15	NFKB1	NFKB1	NFKB1	4559	0.081	0.59	NO
16	MAP3K14	MAP3K14	MAP3K14	5346	0.06	0.56	NO
17	CHUK	CHUK	CHUK	6570	0.032	0.5	NO
18	TOLLIP	TOLLIP	TOLLIP	7069	0.022	0.47	NO
19	ECSIT	ECSIT	ECSIT	7305	0.016	0.46	NO
20	MAPK14	MAPK14	MAPK14	7421	0.014	0.46	NO
21	RELA	RELA	RELA	7670	0.0085	0.45	NO
22	TAB2	TAB2	TAB2	7689	0.0082	0.45	NO
23	TLR3	TLR3	TLR3	7811	0.0055	0.44	NO
24	EIF2AK2	EIF2AK2	EIF2AK2	8112	-0.00081	0.43	NO
25	FOS	FOS	FOS	8297	-0.0043	0.42	NO
26	ELK1	ELK1	ELK1	8364	-0.006	0.42	NO
27	JUN	JUN	JUN	8616	-0.012	0.4	NO
28	TLR9	TLR9	TLR9	9160	-0.023	0.38	NO
29	MAP3K7	MAP3K7	MAP3K7	9735	-0.035	0.35	NO
30	IKBKB	IKBKB	IKBKB	9776	-0.036	0.36	NO
31	TAB1	TAB1	TAB1	10151	-0.044	0.35	NO
32	MAP2K4	MAP2K4	MAP2K4	10976	-0.061	0.31	NO
33	TRAF6	TRAF6	TRAF6	11070	-0.063	0.32	NO
34	MAPK8	MAPK8	MAPK8	11620	-0.075	0.3	NO
35	PGLYRP1	PGLYRP1	PGLYRP1	11896	-0.082	0.31	NO
36	TIRAP	TIRAP	TIRAP	14964	-0.2	0.18	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA AGR PATHWAY	35	genes.ES.table	0.47	1.4	0.1	0.52	0.97	0.23	0.078	0.21	0.42	0.11
BIOCARTA BIOPEPTIDES PATHWAY	39	genes.ES.table	0.45	1.6	0.041	0.36	0.81	0.2	0.16	0.17	0.26	0.062
BIOCARTA CARM ER PATHWAY	34	genes.ES.table	0.37	1.3	0.15	0.57	0.98	0.15	0.11	0.13	0.47	0.13
BIOCARTA INTEGRIN PATHWAY	37	genes.ES.table	0.54	1.8	0.0021	0.39	0.24	0.27	0.14	0.23	0	0.14
BIOCARTA MYOSIN PATHWAY	28	genes.ES.table	0.55	1.7	0.015	0.26	0.6	0.25	0.11	0.22	0.15	0.04
BIOCARTA CHREBP2 PATHWAY	41	genes.ES.table	0.43	1.6	0.032	0.28	0.7	0.32	0.22	0.25	0.17	0.046
BIOCARTA RHO PATHWAY	31	genes.ES.table	0.5	1.8	0.0062	0.18	0.39	0.26	0.11	0.23	0	0.031
BIOCARTA CREB PATHWAY	26	genes.ES.table	0.45	1.4	0.14	0.56	0.98	0.31	0.23	0.24	0.47	0.12
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION	43	genes.ES.table	0.41	1.5	0.066	0.32	0.83	0.49	0.35	0.32	0.23	0.045
KEGG LYSINE DEGRADATION	43	genes.ES.table	0.46	1.8	0.016	0.18	0.32	0.51	0.33	0.34	0	0.044

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PPP1R12B	PPP1R12B	PPP1R12B	45	1.2	0.16	YES
2	ACTA1	ACTA1	ACTA1	349	0.67	0.24	YES
3	TNS1	TNS1	TNS1	901	0.44	0.28	YES
4	ACTN2	ACTN2	ACTN2	904	0.44	0.34	YES
5	ACTN1	ACTN1	ACTN1	926	0.44	0.4	YES
6	ITGA1	ITGA1	ITGA1	1119	0.4	0.45	YES
7	SRC	SRC	SRC	1419	0.35	0.48	YES
8	VCL	VCL	VCL	1594	0.32	0.52	YES
9	ROCK1	ROCK1	ROCK1	1973	0.27	0.54	YES
10	RAP1A	RAP1A	RAP1A	2470	0.23	0.54	YES
11	CAV1	CAV1	CAV1	3205	0.17	0.53	NO
12	ZYX	ZYX	ZYX	3528	0.16	0.53	NO
13	ITGB1	ITGB1	ITGB1	4445	0.12	0.5	NO
14	PTK2	PTK2	PTK2	5503	0.081	0.45	NO
15	SOS1	SOS1	SOS1	5848	0.07	0.44	NO
16	RAF1	RAF1	RAF1	6420	0.054	0.42	NO
17	MAPK1	MAPK1	MAPK1	6723	0.046	0.41	NO
18	SHC1	SHC1	SHC1	7784	0.019	0.35	NO
19	MAP2K1	MAP2K1	MAP2K1	8904	-0.0065	0.29	NO
20	CAPN1	CAPN1	CAPN1	8924	-0.007	0.29	NO
21	JUN	JUN	JUN	9536	-0.021	0.26	NO
22	RHOA	RHOA	RHOA	9594	-0.023	0.26	NO
23	MAPK8	MAPK8	MAPK8	9653	-0.024	0.26	NO
24	ACTN3	ACTN3	ACTN3	9805	-0.028	0.26	NO
25	CRKL	CRKL	CRKL	9856	-0.029	0.26	NO
26	HRAS	HRAS	HRAS	10255	-0.039	0.24	NO
27	RAPGEF1	RAPGEF1	RAPGEF1	10974	-0.056	0.21	NO
28	BCR	BCR	BCR	11097	-0.06	0.21	NO
29	BCAR1	BCAR1	BCAR1	11296	-0.065	0.21	NO
30	CAPNS1	CAPNS1	CAPNS1	11356	-0.067	0.22	NO
31	GRB2	GRB2	GRB2	11425	-0.068	0.22	NO
32	MAPK3	MAPK3	MAPK3	11447	-0.069	0.23	NO
33	MAP2K2	MAP2K2	MAP2K2	13218	-0.12	0.15	NO
34	PXN	PXN	PXN	14019	-0.15	0.13	NO
35	CSK	CSK	CSK	14286	-0.16	0.14	NO
36	CAPNS2	CAPNS2	CAPNS2	15355	-0.22	0.11	NO
37	FYN	FYN	FYN	16272	-0.3	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ALDH1B1	ALDH1B1	ALDH1B1	230	0.77	0.12	YES
2	ACSM1	ACSM1	ACSM1	477	0.6	0.21	YES
3	BDH1	BDH1	BDH1	722	0.5	0.29	YES
4	GAD1	GAD1	GAD1	920	0.44	0.35	YES
5	OXCT1	OXCT1	OXCT1	1042	0.41	0.42	YES
6	L2HGDH	L2HGDH	L2HGDH	1394	0.35	0.46	YES
7	HADH	HADH	HADH	1433	0.34	0.52	YES
8	ALDH3A2	ALDH3A2	ALDH3A2	1731	0.3	0.56	YES
9	AKR1B10	AKR1B10	AKR1B10	2114	0.26	0.58	YES
10	ACAT2	ACAT2	ACAT2	2606	0.21	0.59	YES
11	ACAT1	ACAT1	ACAT1	2900	0.19	0.61	YES
12	ACSM5	ACSM5	ACSM5	2955	0.19	0.64	YES
13	ACSM3	ACSM3	ACSM3	3725	0.15	0.62	YES
14	ALDH2	ALDH2	ALDH2	3781	0.14	0.64	YES
15	ACSM2A	ACSM2A	ACSM2A	4210	0.13	0.64	NO
16	ALDH5A1	ALDH5A1	ALDH5A1	5474	0.082	0.59	NO
17	PDHB	PDHB	PDHB	6308	0.057	0.55	NO
18	PDHA1	PDHA1	PDHA1	7053	0.037	0.52	NO
19	ACADS	ACADS	ACADS	7532	0.026	0.5	NO
20	ABAT	ABAT	ABAT	7948	0.015	0.48	NO
21	OXCT2	OXCT2	OXCT2	8602	0.00018	0.44	NO
22	HMGCS2	HMGCS2	HMGCS2	9069	-0.01	0.42	NO
23	HMGCS1	HMGCS1	HMGCS1	9221	-0.014	0.41	NO
24	ALDH9A1	ALDH9A1	ALDH9A1	9226	-0.014	0.41	NO
25	ALDH7A1	ALDH7A1	ALDH7A1	9604	-0.023	0.4	NO
26	HMGCL	HMGCL	HMGCL	10278	-0.039	0.36	NO
27	AACS	AACS	AACS	10611	-0.048	0.36	NO
28	HADHA	HADHA	HADHA	11838	-0.079	0.3	NO
29	ECHS1	ECHS1	ECHS1	12504	-0.099	0.28	NO
30	BDH2	BDH2	BDH2	14458	-0.17	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ALDH1B1	ALDH1B1	ALDH1B1	230	0.77	0.12	YES
2	SETMAR	SETMAR	SETMAR	619	0.54	0.2	YES
3	HADH	HADH	HADH	1433	0.34	0.22	YES
4	ALDH3A2	ALDH3A2	ALDH3A2	1731	0.3	0.26	YES
5	BBOX1	BBOX1	BBOX1	2295	0.24	0.27	YES
6	PIPOX	PIPOX	PIPOX	2458	0.23	0.3	YES
7	ACAT2	ACAT2	ACAT2	2606	0.21	0.33	YES
8	SETD1B	SETD1B	SETD1B	2855	0.2	0.35	YES
9	ACAT1	ACAT1	ACAT1	2900	0.19	0.38	YES
10	ASH1L	ASH1L	ASH1L	3067	0.18	0.41	YES
11	OGDHL	OGDHL	OGDHL	3648	0.15	0.4	YES
12	ALDH2	ALDH2	ALDH2	3781	0.14	0.42	YES
13	WHSC1	WHSC1	WHSC1	4401	0.12	0.41	YES
14	AADAT	AADAT	AADAT	4417	0.12	0.43	YES
15	SETD8	SETD8	SETD8	4430	0.12	0.45	YES
16	PLOD2	PLOD2	PLOD2	4900	0.099	0.44	YES
17	TMLHE	TMLHE	TMLHE	5058	0.095	0.45	YES
18	SETD2	SETD2	SETD2	5248	0.088	0.45	YES
19	SUV39H1	SUV39H1	SUV39H1	5329	0.086	0.46	YES
20	OGDH	OGDH	OGDH	5631	0.076	0.46	YES
21	WHSC1L1	WHSC1L1	WHSC1L1	5930	0.068	0.46	YES
22	DOT1L	DOT1L	DOT1L	6007	0.066	0.46	YES
23	SETD7	SETD7	SETD7	6805	0.043	0.43	NO
24	SETD1A	SETD1A	SETD1A	6903	0.041	0.43	NO
25	DLST	DLST	DLST	8266	0.0077	0.36	NO
26	SETDB1	SETDB1	SETDB1	8322	0.0066	0.35	NO
27	EHMT2	EHMT2	EHMT2	8808	-0.0042	0.33	NO
28	AASS	AASS	AASS	8912	-0.0068	0.32	NO
29	AASDH	AASDH	AASDH	9145	-0.012	0.31	NO
30	ALDH9A1	ALDH9A1	ALDH9A1	9226	-0.014	0.31	NO
31	EHMT1	EHMT1	EHMT1	9255	-0.015	0.31	NO
32	NSD1	NSD1	NSD1	9522	-0.02	0.3	NO
33	GCDH	GCDH	GCDH	9570	-0.022	0.3	NO
34	ALDH7A1	ALDH7A1	ALDH7A1	9604	-0.023	0.3	NO
35	AASDHPPT	AASDHPPT	AASDHPPT	10441	-0.043	0.26	NO
36	SUV420H2	SUV420H2	SUV420H2	10599	-0.047	0.26	NO
37	SUV420H1	SUV420H1	SUV420H1	10652	-0.048	0.27	NO
38	HADHA	HADHA	HADHA	11838	-0.079	0.22	NO
39	ECHS1	ECHS1	ECHS1	12504	-0.099	0.2	NO
40	SETDB2	SETDB2	SETDB2	13326	-0.12	0.18	NO
41	SUV39H2	SUV39H2	SUV39H2	13644	-0.14	0.18	NO
42	PLOD3	PLOD3	PLOD3	14215	-0.16	0.18	NO
43	PLOD1	PLOD1	PLOD1	15042	-0.2	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYLK	MYLK	MYLK	43	1.2	0.16	YES
2	PPP1R12B	PPP1R12B	PPP1R12B	45	1.2	0.33	YES
3	SRC	SRC	SRC	1419	0.35	0.3	YES
4	ARHGEF5	ARHGEF5	ARHGEF5	1435	0.34	0.35	YES
5	PIP5K1B	PIP5K1B	PIP5K1B	1446	0.34	0.4	YES
6	VCL	VCL	VCL	1594	0.32	0.44	YES
7	ARHGAP6	ARHGAP6	ARHGAP6	1839	0.29	0.46	YES
8	ROCK1	ROCK1	ROCK1	1973	0.27	0.5	YES
9	GSN	GSN	GSN	2946	0.19	0.47	NO
10	ARHGAP1	ARHGAP1	ARHGAP1	3108	0.18	0.49	NO
11	ARHGAP5	ARHGAP5	ARHGAP5	4938	0.098	0.4	NO
12	OPHN1	OPHN1	OPHN1	5026	0.096	0.41	NO
13	ACTR3	ACTR3	ACTR3	5828	0.071	0.37	NO
14	PIP5K1A	PIP5K1A	PIP5K1A	6726	0.046	0.33	NO
15	ARPC5	ARPC5	ARPC5	6984	0.039	0.32	NO
16	DIAPH1	DIAPH1	DIAPH1	8716	-0.0024	0.23	NO
17	ARHGEF11	ARHGEF11	ARHGEF11	8800	-0.0041	0.22	NO
18	PFN1	PFN1	PFN1	9138	-0.012	0.21	NO
19	RHOA	RHOA	RHOA	9594	-0.023	0.18	NO
20	ARPC1A	ARPC1A	ARPC1A	9783	-0.027	0.18	NO
21	ARPC2	ARPC2	ARPC2	9879	-0.029	0.18	NO
22	ARPC4	ARPC4	ARPC4	10435	-0.043	0.15	NO
23	CFL1	CFL1	CFL1	11139	-0.061	0.12	NO
24	ACTR2	ACTR2	ACTR2	12363	-0.094	0.068	NO
25	ARHGEF1	ARHGEF1	ARHGEF1	12614	-0.1	0.069	NO
26	ARPC3	ARPC3	ARPC3	13161	-0.12	0.056	NO
27	ARPC1B	ARPC1B	ARPC1B	15803	-0.26	-0.054	NO
28	BAIAP2	BAIAP2	BAIAP2	15826	-0.26	-0.018	NO
29	ARHGAP4	ARHGAP4	ARHGAP4	15980	-0.27	0.011	NO
30	MYL2	MYL2	MYL2	16267	-0.3	0.038	NO
31	LIMK1	LIMK1	LIMK1	17565	-0.47	0.033	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ALDH1B1	ALDH1B1	ALDH1B1	230	0.77	0.19	YES
2	ALDH3A2	ALDH3A2	ALDH3A2	1731	0.3	0.19	YES
3	ACACB	ACACB	ACACB	2085	0.26	0.24	YES
4	LDHAL6B	LDHAL6B	LDHAL6B	2238	0.25	0.29	YES
5	ACAT2	ACAT2	ACAT2	2606	0.21	0.33	YES
6	ALDH6A1	ALDH6A1	ALDH6A1	2886	0.2	0.36	YES
7	ACAT1	ACAT1	ACAT1	2900	0.19	0.42	YES
8	ALDH2	ALDH2	ALDH2	3781	0.14	0.4	YES
9	ACSS3	ACSS3	ACSS3	3996	0.14	0.43	YES
10	EHHADH	EHHADH	EHHADH	4199	0.13	0.45	YES
11	SUCLG2	SUCLG2	SUCLG2	4655	0.11	0.45	YES
12	ACACA	ACACA	ACACA	4860	0.1	0.47	YES
13	PCCB	PCCB	PCCB	4983	0.097	0.49	YES
14	PCCA	PCCA	PCCA	5118	0.093	0.5	YES
15	ACADM	ACADM	ACADM	5267	0.088	0.52	YES
16	HIBCH	HIBCH	HIBCH	5531	0.08	0.53	YES
17	LDHAL6A	LDHAL6A	LDHAL6A	5841	0.07	0.53	YES
18	ACSS2	ACSS2	ACSS2	6485	0.052	0.5	NO
19	MUT	MUT	MUT	7011	0.038	0.49	NO
20	LDHB	LDHB	LDHB	7095	0.036	0.49	NO
21	ABAT	ABAT	ABAT	7948	0.015	0.45	NO
22	SUCLA2	SUCLA2	SUCLA2	7984	0.014	0.45	NO
23	MLYCD	MLYCD	MLYCD	8014	0.014	0.45	NO
24	SUCLG1	SUCLG1	SUCLG1	8611	0.000046	0.42	NO
25	ALDH9A1	ALDH9A1	ALDH9A1	9226	-0.014	0.39	NO
26	ALDH7A1	ALDH7A1	ALDH7A1	9604	-0.023	0.37	NO
27	MCEE	MCEE	MCEE	11026	-0.058	0.31	NO
28	LDHA	LDHA	LDHA	11203	-0.062	0.32	NO
29	ACSS1	ACSS1	ACSS1	11591	-0.073	0.32	NO
30	HADHA	HADHA	HADHA	11838	-0.079	0.32	NO
31	ECHS1	ECHS1	ECHS1	12504	-0.099	0.31	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYLK	MYLK	MYLK	43	1.2	0.19	YES
2	PPP1R12B	PPP1R12B	PPP1R12B	45	1.2	0.39	YES
3	ARHGEF4	ARHGEF4	ARHGEF4	1388	0.35	0.37	YES
4	ARHGEF5	ARHGEF5	ARHGEF5	1435	0.34	0.43	YES
5	ARHGEF17	ARHGEF17	ARHGEF17	1702	0.31	0.46	YES
6	ARHGEF9	ARHGEF9	ARHGEF9	1752	0.3	0.51	YES
7	ROCK1	ROCK1	ROCK1	1973	0.27	0.55	YES
8	PLCB1	PLCB1	PLCB1	3150	0.18	0.51	NO
9	ARHGEF10	ARHGEF10	ARHGEF10	3739	0.14	0.5	NO
10	ARHGEF12	ARHGEF12	ARHGEF12	4590	0.11	0.47	NO
11	GNAQ	GNAQ	GNAQ	4699	0.11	0.48	NO
12	ARHGAP5	ARHGAP5	ARHGAP5	4938	0.098	0.49	NO
13	PKN1	PKN1	PKN1	5864	0.07	0.45	NO
14	ARHGEF3	ARHGEF3	ARHGEF3	6625	0.048	0.42	NO
15	ARHGEF7	ARHGEF7	ARHGEF7	7463	0.027	0.37	NO
16	GNA12	GNA12	GNA12	7565	0.024	0.37	NO
17	ARHGEF2	ARHGEF2	ARHGEF2	8114	0.012	0.34	NO
18	ARHGEF18	ARHGEF18	ARHGEF18	8272	0.0076	0.34	NO
19	ARHGEF11	ARHGEF11	ARHGEF11	8800	-0.0041	0.31	NO
20	ARHGEF16	ARHGEF16	ARHGEF16	8900	-0.0064	0.3	NO
21	PRKCB	PRKCB	PRKCB	9695	-0.025	0.26	NO
22	ARHGEF6	ARHGEF6	ARHGEF6	10532	-0.046	0.23	NO
23	PRKCA	PRKCA	PRKCA	12566	-0.1	0.13	NO
24	ARHGEF1	ARHGEF1	ARHGEF1	12614	-0.1	0.14	NO
25	ARHGEF15	ARHGEF15	ARHGEF15	12829	-0.11	0.15	NO
26	GNB1	GNB1	GNB1	13349	-0.13	0.14	NO
27	MYL2	MYL2	MYL2	16267	-0.3	0.033	NO
28	ARHGEF19	ARHGEF19	ARHGEF19	17356	-0.43	0.045	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYH11	MYH11	MYH11	3	1.6	0.051	YES
2	KCNMB1	KCNMB1	KCNMB1	6	1.6	0.1	YES
3	ACTG2	ACTG2	ACTG2	28	1.2	0.14	YES
4	RAMP1	RAMP1	RAMP1	37	1.2	0.18	YES
5	MYLK	MYLK	MYLK	43	1.2	0.21	YES
6	PPP1R12B	PPP1R12B	PPP1R12B	45	1.2	0.25	YES
7	MRVI1	MRVI1	MRVI1	50	1.1	0.28	YES
8	PPP1R14A	PPP1R14A	PPP1R14A	83	1	0.32	YES
9	ADCY5	ADCY5	ADCY5	128	0.91	0.34	YES
10	ADRA1A	ADRA1A	ADRA1A	129	0.91	0.37	YES
11	ITPR1	ITPR1	ITPR1	186	0.81	0.39	YES
12	CACNA1C	CACNA1C	CACNA1C	277	0.73	0.41	YES
13	ACTA2	ACTA2	ACTA2	280	0.72	0.43	YES
14	KCNMA1	KCNMA1	KCNMA1	310	0.7	0.45	YES
15	MYL9	MYL9	MYL9	342	0.68	0.47	YES
16	PLA2G10	PLA2G10	PLA2G10	608	0.54	0.48	YES
17	PLCB4	PLCB4	PLCB4	682	0.52	0.49	YES
18	ADCY2	ADCY2	ADCY2	811	0.47	0.5	YES
19	PRKG1	PRKG1	PRKG1	943	0.44	0.5	YES
20	EDNRA	EDNRA	EDNRA	1015	0.42	0.51	YES
21	CALD1	CALD1	CALD1	1182	0.39	0.51	YES
22	PPP1R12A	PPP1R12A	PPP1R12A	1242	0.38	0.52	YES
23	GNA11	GNA11	GNA11	1631	0.32	0.51	NO
24	ROCK2	ROCK2	ROCK2	1804	0.3	0.51	NO
25	ROCK1	ROCK1	ROCK1	1973	0.27	0.51	NO
26	ADCY9	ADCY9	ADCY9	2716	0.2	0.48	NO
27	NPR1	NPR1	NPR1	2748	0.2	0.48	NO
28	CACNA1D	CACNA1D	CACNA1D	2902	0.19	0.48	NO
29	PRKCG	PRKCG	PRKCG	2903	0.19	0.48	NO
30	PPP1CB	PPP1CB	PPP1CB	3102	0.18	0.48	NO
31	PLCB1	PLCB1	PLCB1	3150	0.18	0.48	NO
32	MYLK3	MYLK3	MYLK3	3259	0.17	0.48	NO
33	PLA2G6	PLA2G6	PLA2G6	3315	0.17	0.48	NO
34	MYL6	MYL6	MYL6	3415	0.16	0.48	NO
35	PLA2G3	PLA2G3	PLA2G3	3540	0.15	0.48	NO
36	NPR2	NPR2	NPR2	3572	0.15	0.48	NO
37	ADCY6	ADCY6	ADCY6	3624	0.15	0.49	NO
38	PRKACB	PRKACB	PRKACB	3658	0.15	0.49	NO
39	PLA2G12A	PLA2G12A	PLA2G12A	3752	0.14	0.49	NO
40	PRKACG	PRKACG	PRKACG	3901	0.14	0.48	NO
41	GUCY1A3	GUCY1A3	GUCY1A3	4235	0.12	0.47	NO
42	ARHGEF12	ARHGEF12	ARHGEF12	4590	0.11	0.45	NO
43	GNAQ	GNAQ	GNAQ	4699	0.11	0.45	NO
44	JMJD7-PLA2G4B	JMJD7-PLA2G4B	JMJD7-PLA2G4B	4767	0.1	0.45	NO
45	PLCB3	PLCB3	PLCB3	4920	0.099	0.45	NO
46	CALM1	CALM1	CALM1	5251	0.088	0.43	NO
47	RAMP3	RAMP3	RAMP3	5550	0.079	0.42	NO
48	PRKACA	PRKACA	PRKACA	5611	0.077	0.42	NO
49	GNA13	GNA13	GNA13	5934	0.067	0.4	NO
50	BRAF	BRAF	BRAF	6324	0.057	0.38	NO
51	RAF1	RAF1	RAF1	6420	0.054	0.38	NO
52	MAPK1	MAPK1	MAPK1	6723	0.046	0.36	NO
53	ADCY8	ADCY8	ADCY8	7200	0.034	0.34	NO
54	GNA12	GNA12	GNA12	7565	0.024	0.32	NO
55	PRKCD	PRKCD	PRKCD	7794	0.019	0.3	NO
56	KCNMB3	KCNMB3	KCNMB3	8085	0.012	0.29	NO
57	ADCY1	ADCY1	ADCY1	8171	0.01	0.28	NO
58	CALCRL	CALCRL	CALCRL	8192	0.0097	0.28	NO
59	ARHGEF11	ARHGEF11	ARHGEF11	8800	-0.0041	0.25	NO
60	MAP2K1	MAP2K1	MAP2K1	8904	-0.0065	0.24	NO
61	CALM3	CALM3	CALM3	8945	-0.0074	0.24	NO
62	CALML3	CALML3	CALML3	9044	-0.0097	0.24	NO
63	GUCY1B3	GUCY1B3	GUCY1B3	9266	-0.015	0.23	NO
64	RHOA	RHOA	RHOA	9594	-0.023	0.21	NO
65	PRKCB	PRKCB	PRKCB	9695	-0.025	0.2	NO
66	ARAF	ARAF	ARAF	9767	-0.026	0.2	NO
67	PPP1CC	PPP1CC	PPP1CC	10311	-0.04	0.17	NO
68	CALM2	CALM2	CALM2	10423	-0.043	0.17	NO
69	GNAS	GNAS	GNAS	10460	-0.044	0.17	NO
70	ADRA1D	ADRA1D	ADRA1D	10481	-0.045	0.17	NO
71	CACNA1F	CACNA1F	CACNA1F	11261	-0.064	0.13	NO
72	MAPK3	MAPK3	MAPK3	11447	-0.069	0.12	NO
73	PRKCA	PRKCA	PRKCA	12566	-0.1	0.059	NO
74	ARHGEF1	ARHGEF1	ARHGEF1	12614	-0.1	0.059	NO
75	MAP2K2	MAP2K2	MAP2K2	13218	-0.12	0.03	NO
76	PRKCQ	PRKCQ	PRKCQ	13226	-0.12	0.033	NO
77	MYL6B	MYL6B	MYL6B	13609	-0.14	0.016	NO
78	PLA2G12B	PLA2G12B	PLA2G12B	13622	-0.14	0.02	NO
79	PRKCH	PRKCH	PRKCH	13732	-0.14	0.018	NO
80	PLA2G2D	PLA2G2D	PLA2G2D	13771	-0.14	0.021	NO
81	ADORA2A	ADORA2A	ADORA2A	13868	-0.14	0.02	NO
82	PPP1CA	PPP1CA	PPP1CA	13937	-0.15	0.021	NO
83	RAMP2	RAMP2	RAMP2	13953	-0.15	0.025	NO
84	ITPR2	ITPR2	ITPR2	14088	-0.15	0.022	NO
85	CALML6	CALML6	CALML6	14095	-0.16	0.027	NO
86	ADCY4	ADCY4	ADCY4	14220	-0.16	0.025	NO
87	PRKCE	PRKCE	PRKCE	14250	-0.16	0.028	NO
88	GUCY1A2	GUCY1A2	GUCY1A2	14465	-0.17	0.022	NO
89	ITPR3	ITPR3	ITPR3	14840	-0.19	0.0072	NO
90	CYP4A11	CYP4A11	CYP4A11	14871	-0.19	0.012	NO
91	CACNA1S	CACNA1S	CACNA1S	14940	-0.2	0.014	NO
92	PLA2G5	PLA2G5	PLA2G5	15045	-0.2	0.015	NO
93	AVPR1A	AVPR1A	AVPR1A	15321	-0.22	0.0063	NO
94	PRKX	PRKX	PRKX	15421	-0.23	0.008	NO
95	ADRA1B	ADRA1B	ADRA1B	15435	-0.23	0.014	NO
96	PLA2G4A	PLA2G4A	PLA2G4A	15784	-0.25	0.0031	NO
97	PLA2G1B	PLA2G1B	PLA2G1B	15858	-0.26	0.0073	NO
98	PTGIR	PTGIR	PTGIR	15895	-0.26	0.014	NO
99	AGTR1	AGTR1	AGTR1	16304	-0.3	0.00044	NO
100	MYLK2	MYLK2	MYLK2	16548	-0.32	-0.0028	NO
101	ADCY7	ADCY7	ADCY7	16555	-0.32	0.0071	NO
102	ADORA2B	ADORA2B	ADORA2B	16691	-0.34	0.01	NO
103	PLCB2	PLCB2	PLCB2	17159	-0.4	-0.003	NO
104	KCNMB2	KCNMB2	KCNMB2	17613	-0.48	-0.013	NO
105	PLA2G2A	PLA2G2A	PLA2G2A	17953	-0.6	-0.013	NO
106	KCNMB4	KCNMB4	KCNMB4	18103	-0.78	0.0035	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKAA2	PRKAA2	PRKAA2	177	0.82	0.13	YES
2	PRKAG2	PRKAG2	PRKAG2	702	0.51	0.19	YES
3	PPP2R2B	PPP2R2B	PPP2R2B	1198	0.39	0.22	YES
4	PPP2R2C	PPP2R2C	PPP2R2C	1545	0.33	0.26	YES
5	PRKAR2A	PRKAR2A	PRKAR2A	1575	0.32	0.31	YES
6	PRKAB2	PRKAB2	PRKAB2	2121	0.26	0.33	YES
7	PPP2R5A	PPP2R5A	PPP2R5A	2212	0.25	0.36	YES
8	PRKAR2B	PRKAR2B	PRKAR2B	2215	0.25	0.41	YES
9	YWHAH	YWHAH	YWHAH	3123	0.18	0.38	YES
10	PRKAA1	PRKAA1	PRKAA1	3410	0.16	0.4	YES
11	PRKACB	PRKACB	PRKACB	3658	0.15	0.41	YES
12	PRKACG	PRKACG	PRKACG	3901	0.14	0.42	YES
13	PPP2R3A	PPP2R3A	PPP2R3A	4022	0.13	0.43	YES
14	ACACA	ACACA	ACACA	4860	0.1	0.4	NO
15	PRKACA	PRKACA	PRKACA	5611	0.077	0.38	NO
16	PPP2R5E	PPP2R5E	PPP2R5E	5867	0.069	0.37	NO
17	GCK	GCK	GCK	5886	0.069	0.38	NO
18	YWHAZ	YWHAZ	YWHAZ	6656	0.048	0.35	NO
19	PPP2R5B	PPP2R5B	PPP2R5B	6841	0.042	0.35	NO
20	PPP2CA	PPP2CA	PPP2CA	6934	0.04	0.35	NO
21	PPP2CB	PPP2CB	PPP2CB	7768	0.02	0.31	NO
22	YWHAQ	YWHAQ	YWHAQ	7967	0.015	0.3	NO
23	PRKAG1	PRKAG1	PRKAG1	8414	0.0046	0.27	NO
24	PPP2R5D	PPP2R5D	PPP2R5D	8925	-0.007	0.25	NO
25	PRKAR1A	PRKAR1A	PRKAR1A	8953	-0.0076	0.25	NO
26	PPP2R5C	PPP2R5C	PPP2R5C	8969	-0.0079	0.25	NO
27	PRKAB1	PRKAB1	PRKAB1	9243	-0.015	0.23	NO
28	MLX	MLX	MLX	9247	-0.015	0.24	NO
29	PPP2R2A	PPP2R2A	PPP2R2A	9779	-0.027	0.21	NO
30	PKLR	PKLR	PKLR	9877	-0.029	0.21	NO
31	YWHAG	YWHAG	YWHAG	9951	-0.031	0.21	NO
32	YWHAB	YWHAB	YWHAB	10383	-0.042	0.2	NO
33	PPP2R4	PPP2R4	PPP2R4	10833	-0.053	0.18	NO
34	PPP2R1A	PPP2R1A	PPP2R1A	11574	-0.072	0.15	NO
35	PPP2R3B	PPP2R3B	PPP2R3B	11649	-0.074	0.16	NO
36	PPP2R1B	PPP2R1B	PPP2R1B	11978	-0.083	0.16	NO
37	FASN	FASN	FASN	12706	-0.1	0.13	NO
38	PPP2R2D	PPP2R2D	PPP2R2D	14256	-0.16	0.075	NO
39	YWHAE	YWHAE	YWHAE	14397	-0.17	0.095	NO
40	PRKAR1B	PRKAR1B	PRKAR1B	15437	-0.23	0.076	NO
41	MLXIPL	MLXIPL	MLXIPL	17436	-0.44	0.04	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYLK	MYLK	MYLK	43	1.2	0.2	YES
2	MAPT	MAPT	MAPT	416	0.63	0.28	YES
3	CAMK2A	CAMK2A	CAMK2A	728	0.5	0.35	YES
4	GNA11	GNA11	GNA11	1631	0.32	0.35	YES
5	CAMK2G	CAMK2G	CAMK2G	1701	0.31	0.4	YES
6	STAT5B	STAT5B	STAT5B	2199	0.25	0.42	YES
7	PTK2B	PTK2B	PTK2B	2569	0.22	0.43	YES
8	JAK2	JAK2	JAK2	2834	0.2	0.45	YES
9	STAT6	STAT6	STAT6	3504	0.16	0.44	NO
10	CALM1	CALM1	CALM1	5251	0.088	0.36	NO
11	AGT	AGT	AGT	5488	0.081	0.36	NO
12	SOS1	SOS1	SOS1	5848	0.07	0.35	NO
13	CAMK2B	CAMK2B	CAMK2B	5943	0.067	0.36	NO
14	STAT3	STAT3	STAT3	6065	0.064	0.36	NO
15	RAF1	RAF1	RAF1	6420	0.054	0.35	NO
16	MAPK1	MAPK1	MAPK1	6723	0.046	0.34	NO
17	F2	F2	F2	7105	0.036	0.33	NO
18	SHC1	SHC1	SHC1	7784	0.019	0.3	NO
19	STAT1	STAT1	STAT1	8237	0.0086	0.27	NO
20	PLCG1	PLCG1	PLCG1	8570	0.0011	0.25	NO
21	MAPK14	MAPK14	MAPK14	8846	-0.0054	0.24	NO
22	MAP2K1	MAP2K1	MAP2K1	8904	-0.0065	0.24	NO
23	CALM3	CALM3	CALM3	8945	-0.0074	0.24	NO
24	GNAI1	GNAI1	GNAI1	8968	-0.0079	0.24	NO
25	MAPK8	MAPK8	MAPK8	9653	-0.024	0.2	NO
26	PRKCB	PRKCB	PRKCB	9695	-0.025	0.2	NO
27	STAT5A	STAT5A	STAT5A	10073	-0.034	0.19	NO
28	CAMK2D	CAMK2D	CAMK2D	10135	-0.036	0.19	NO
29	AGTR2	AGTR2	AGTR2	10393	-0.042	0.19	NO
30	CALM2	CALM2	CALM2	10423	-0.043	0.19	NO
31	GRB2	GRB2	GRB2	11425	-0.068	0.15	NO
32	MAPK3	MAPK3	MAPK3	11447	-0.069	0.16	NO
33	CDK5	CDK5	CDK5	11860	-0.08	0.15	NO
34	PRKCA	PRKCA	PRKCA	12566	-0.1	0.13	NO
35	MAP2K2	MAP2K2	MAP2K2	13218	-0.12	0.11	NO
36	GNB1	GNB1	GNB1	13349	-0.13	0.13	NO
37	STAT2	STAT2	STAT2	13848	-0.14	0.12	NO
38	FYN	FYN	FYN	16272	-0.3	0.039	NO
39	STAT4	STAT4	STAT4	17070	-0.38	0.06	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SORBS1	SORBS1	SORBS1	61	1.1	0.043	YES
2	PRKAA2	PRKAA2	PRKAA2	177	0.82	0.071	YES
3	PPARGC1A	PPARGC1A	PPARGC1A	200	0.8	0.1	YES
4	MAPK10	MAPK10	MAPK10	210	0.79	0.14	YES
5	SOCS2	SOCS2	SOCS2	265	0.74	0.16	YES
6	PHKG1	PHKG1	PHKG1	275	0.73	0.19	YES
7	PDE3A	PDE3A	PDE3A	323	0.69	0.22	YES
8	PPP1R3C	PPP1R3C	PPP1R3C	357	0.67	0.24	YES
9	PHKA1	PHKA1	PHKA1	381	0.65	0.27	YES
10	SLC2A4	SLC2A4	SLC2A4	564	0.56	0.28	YES
11	PPP1R3B	PPP1R3B	PPP1R3B	634	0.54	0.3	YES
12	PRKAG2	PRKAG2	PRKAG2	702	0.51	0.32	YES
13	PTPRF	PTPRF	PTPRF	717	0.51	0.34	YES
14	AKT3	AKT3	AKT3	1068	0.41	0.34	YES
15	PYGM	PYGM	PYGM	1216	0.38	0.34	YES
16	PRKAR2A	PRKAR2A	PRKAR2A	1575	0.32	0.34	YES
17	ACACB	ACACB	ACACB	2085	0.26	0.32	YES
18	PRKAB2	PRKAB2	PRKAB2	2121	0.26	0.33	YES
19	PRKAR2B	PRKAR2B	PRKAR2B	2215	0.25	0.33	YES
20	IRS4	IRS4	IRS4	2269	0.24	0.34	YES
21	FLOT2	FLOT2	FLOT2	2498	0.22	0.34	YES
22	PYGB	PYGB	PYGB	2546	0.22	0.34	YES
23	IRS2	IRS2	IRS2	2787	0.2	0.34	YES
24	RPTOR	RPTOR	RPTOR	2799	0.2	0.35	YES
25	CBL	CBL	CBL	2833	0.2	0.35	YES
26	IKBKB	IKBKB	IKBKB	2962	0.19	0.36	YES
27	PPP1CB	PPP1CB	PPP1CB	3102	0.18	0.35	YES
28	SHC2	SHC2	SHC2	3409	0.16	0.34	YES
29	PRKAA1	PRKAA1	PRKAA1	3410	0.16	0.35	YES
30	PRKACB	PRKACB	PRKACB	3658	0.15	0.34	YES
31	PIK3R3	PIK3R3	PIK3R3	3837	0.14	0.34	YES
32	RHEB	RHEB	RHEB	3856	0.14	0.34	YES
33	INSR	INSR	INSR	3898	0.14	0.35	YES
34	PRKACG	PRKACG	PRKACG	3901	0.14	0.35	YES
35	PDPK1	PDPK1	PDPK1	3910	0.14	0.36	YES
36	PIK3CB	PIK3CB	PIK3CB	3953	0.14	0.36	YES
37	PPP1R3D	PPP1R3D	PPP1R3D	3967	0.14	0.37	YES
38	SOS2	SOS2	SOS2	3992	0.14	0.37	YES
39	IRS1	IRS1	IRS1	4175	0.13	0.37	YES
40	PIK3R1	PIK3R1	PIK3R1	4212	0.13	0.37	YES
41	GYS2	GYS2	GYS2	4333	0.12	0.37	YES
42	FOXO1	FOXO1	FOXO1	4339	0.12	0.37	YES
43	PDE3B	PDE3B	PDE3B	4402	0.12	0.37	YES
44	ACACA	ACACA	ACACA	4860	0.1	0.35	NO
45	GSK3B	GSK3B	GSK3B	4975	0.097	0.35	NO
46	SOCS4	SOCS4	SOCS4	5115	0.093	0.35	NO
47	CALM1	CALM1	CALM1	5251	0.088	0.34	NO
48	PRKACA	PRKACA	PRKACA	5611	0.077	0.33	NO
49	SOS1	SOS1	SOS1	5848	0.07	0.32	NO
50	GCK	GCK	GCK	5886	0.069	0.32	NO
51	RHOQ	RHOQ	RHOQ	5929	0.068	0.32	NO
52	MAPK9	MAPK9	MAPK9	6289	0.058	0.3	NO
53	BRAF	BRAF	BRAF	6324	0.057	0.3	NO
54	RAF1	RAF1	RAF1	6420	0.054	0.3	NO
55	TSC2	TSC2	TSC2	6434	0.054	0.3	NO
56	TSC1	TSC1	TSC1	6515	0.052	0.3	NO
57	PRKCI	PRKCI	PRKCI	6708	0.046	0.29	NO
58	SHC4	SHC4	SHC4	6709	0.046	0.29	NO
59	MAPK1	MAPK1	MAPK1	6723	0.046	0.29	NO
60	PIK3CA	PIK3CA	PIK3CA	6763	0.044	0.29	NO
61	TRIP10	TRIP10	TRIP10	7016	0.038	0.28	NO
62	PHKG2	PHKG2	PHKG2	7442	0.028	0.26	NO
63	BAD	BAD	BAD	7454	0.028	0.26	NO
64	PHKA2	PHKA2	PHKA2	7648	0.022	0.25	NO
65	EIF4E	EIF4E	EIF4E	7703	0.021	0.24	NO
66	SHC1	SHC1	SHC1	7784	0.019	0.24	NO
67	AKT1	AKT1	AKT1	7872	0.017	0.24	NO
68	PRKAG1	PRKAG1	PRKAG1	8414	0.0046	0.21	NO
69	GYS1	GYS1	GYS1	8471	0.0031	0.2	NO
70	ELK1	ELK1	ELK1	8634	-0.00057	0.2	NO
71	PTPN1	PTPN1	PTPN1	8717	-0.0024	0.19	NO
72	PCK2	PCK2	PCK2	8805	-0.0042	0.19	NO
73	HK1	HK1	HK1	8883	-0.006	0.18	NO
74	FLOT1	FLOT1	FLOT1	8889	-0.0062	0.18	NO
75	MAP2K1	MAP2K1	MAP2K1	8904	-0.0065	0.18	NO
76	EXOC7	EXOC7	EXOC7	8914	-0.0068	0.18	NO
77	MTOR	MTOR	MTOR	8936	-0.0072	0.18	NO
78	CALM3	CALM3	CALM3	8945	-0.0074	0.18	NO
79	PRKAR1A	PRKAR1A	PRKAR1A	8953	-0.0076	0.18	NO
80	FBP2	FBP2	FBP2	8998	-0.0088	0.18	NO
81	CALML3	CALML3	CALML3	9044	-0.0097	0.18	NO
82	SHC3	SHC3	SHC3	9118	-0.012	0.17	NO
83	PRKAB1	PRKAB1	PRKAB1	9243	-0.015	0.17	NO
84	MAPK8	MAPK8	MAPK8	9653	-0.024	0.14	NO
85	ARAF	ARAF	ARAF	9767	-0.026	0.14	NO
86	CRKL	CRKL	CRKL	9856	-0.029	0.14	NO
87	PHKB	PHKB	PHKB	9867	-0.029	0.14	NO
88	PKLR	PKLR	PKLR	9877	-0.029	0.14	NO
89	AKT2	AKT2	AKT2	9924	-0.031	0.14	NO
90	RPS6KB1	RPS6KB1	RPS6KB1	10030	-0.033	0.13	NO
91	PPP1CC	PPP1CC	PPP1CC	10311	-0.04	0.12	NO
92	CALM2	CALM2	CALM2	10423	-0.043	0.11	NO
93	RPS6KB2	RPS6KB2	RPS6KB2	10622	-0.048	0.1	NO
94	RAPGEF1	RAPGEF1	RAPGEF1	10974	-0.056	0.086	NO
95	CRK	CRK	CRK	10998	-0.057	0.088	NO
96	PYGL	PYGL	PYGL	11017	-0.058	0.089	NO
97	LIPE	LIPE	LIPE	11418	-0.068	0.07	NO
98	GRB2	GRB2	GRB2	11425	-0.068	0.072	NO
99	MAPK3	MAPK3	MAPK3	11447	-0.069	0.074	NO
100	RPS6	RPS6	RPS6	11540	-0.072	0.072	NO
101	MKNK1	MKNK1	MKNK1	11720	-0.076	0.065	NO
102	SREBF1	SREBF1	SREBF1	12047	-0.085	0.05	NO
103	PCK1	PCK1	PCK1	12097	-0.086	0.051	NO
104	EIF4EBP1	EIF4EBP1	EIF4EBP1	12135	-0.088	0.053	NO
105	CBLC	CBLC	CBLC	12318	-0.093	0.047	NO
106	MKNK2	MKNK2	MKNK2	12390	-0.095	0.047	NO
107	CBLB	CBLB	CBLB	12424	-0.096	0.049	NO
108	KRAS	KRAS	KRAS	12432	-0.097	0.052	NO
109	INPP5K	INPP5K	INPP5K	12620	-0.1	0.046	NO
110	FASN	FASN	FASN	12706	-0.1	0.046	NO
111	EIF4E2	EIF4E2	EIF4E2	12947	-0.11	0.037	NO
112	MAP2K2	MAP2K2	MAP2K2	13218	-0.12	0.027	NO
113	PIK3R2	PIK3R2	PIK3R2	13398	-0.13	0.023	NO
114	PPP1CA	PPP1CA	PPP1CA	13937	-0.15	-0.001	NO
115	CALML6	CALML6	CALML6	14095	-0.16	-0.0033	NO
116	PRKX	PRKX	PRKX	15421	-0.23	-0.067	NO
117	PRKAR1B	PRKAR1B	PRKAR1B	15437	-0.23	-0.059	NO
118	NRAS	NRAS	NRAS	15612	-0.24	-0.058	NO
119	PRKCZ	PRKCZ	PRKCZ	16155	-0.28	-0.077	NO
120	PIK3CG	PIK3CG	PIK3CG	16545	-0.32	-0.085	NO
121	PIK3CD	PIK3CD	PIK3CD	16689	-0.34	-0.079	NO
122	SH2B2	SH2B2	SH2B2	16796	-0.35	-0.07	NO
123	INPP5D	INPP5D	INPP5D	16966	-0.37	-0.064	NO
124	SOCS1	SOCS1	SOCS1	17027	-0.38	-0.052	NO
125	HK2	HK2	HK2	17215	-0.4	-0.045	NO
126	FBP1	FBP1	FBP1	17263	-0.41	-0.031	NO
127	SOCS3	SOCS3	SOCS3	17330	-0.42	-0.017	NO
128	PIK3R5	PIK3R5	PIK3R5	17518	-0.46	-0.0081	NO
129	PRKAG3	PRKAG3	PRKAG3	17589	-0.47	0.0077	NO
130	HK3	HK3	HK3	17929	-0.58	0.013	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
BIOCARTA ALK PATHWAY	35	genes.ES.table	0.56	1.6	0.014	0.2	0.69	0.29	0.11	0.25	0.12	0.026
BIOCARTA WNT PATHWAY	25	genes.ES.table	0.61	2	0.0021	0.081	0.066	0.24	0.12	0.21	0	0.028
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM	29	genes.ES.table	0.45	1.3	0.099	0.62	0.99	0.34	0.12	0.3	0.52	0.15
KEGG N GLYCAN BIOSYNTHESIS	45	genes.ES.table	0.37	1.4	0.13	0.66	0.98	0.11	0.12	0.098	0.55	0.18
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE	25	genes.ES.table	0.61	1.6	0.016	0.23	0.64	0.48	0.19	0.39	0.13	0.036
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES	25	genes.ES.table	0.51	1.3	0.14	0.65	0.99	0.36	0.17	0.3	0.54	0.18
KEGG P53 SIGNALING PATHWAY	67	genes.ES.table	0.35	1.2	0.16	0.71	1	0.16	0.13	0.14	0.63	0.19
KEGG ENDOCYTOSIS	180	genes.ES.table	0.27	1.2	0.19	0.75	1	0.12	0.1	0.1	0.67	0.21
KEGG WNT SIGNALING PATHWAY	146	genes.ES.table	0.53	1.8	0.0042	0.16	0.25	0.25	0.13	0.22	0	0.038
KEGG NOTCH SIGNALING PATHWAY	45	genes.ES.table	0.39	1.4	0.14	0.68	0.98	0.31	0.26	0.23	0.56	0.19

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	WIF1	WIF1	WIF1	187	0.55	0.19	YES
2	LEF1	LEF1	LEF1	646	0.41	0.32	YES
3	TLE1	TLE1	TLE1	1241	0.31	0.4	YES
4	CCND1	CCND1	CCND1	1616	0.27	0.48	YES
5	FZD1	FZD1	FZD1	2068	0.23	0.54	YES
6	BTRC	BTRC	BTRC	2246	0.22	0.61	YES
7	CSNK2A1	CSNK2A1	CSNK2A1	4996	0.098	0.5	NO
8	APC	APC	APC	5248	0.091	0.52	NO
9	MAP3K7	MAP3K7	MAP3K7	5929	0.075	0.51	NO
10	CTNNB1	CTNNB1	CTNNB1	6463	0.065	0.5	NO
11	HDAC1	HDAC1	HDAC1	6499	0.064	0.52	NO
12	DVL1	DVL1	DVL1	7590	0.044	0.48	NO
13	CTBP1	CTBP1	CTBP1	7673	0.043	0.49	NO
14	CSNK1D	CSNK1D	CSNK1D	7827	0.04	0.5	NO
15	CREBBP	CREBBP	CREBBP	8008	0.036	0.5	NO
16	MYC	MYC	MYC	8791	0.025	0.47	NO
17	WNT1	WNT1	WNT1	9814	0.0088	0.42	NO
18	NLK	NLK	NLK	10092	0.0046	0.4	NO
19	SMAD4	SMAD4	SMAD4	10148	0.0038	0.4	NO
20	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.36	NO
21	FRAT1	FRAT1	FRAT1	11297	-0.014	0.34	NO
22	AXIN1	AXIN1	AXIN1	11595	-0.019	0.34	NO
23	TAB1	TAB1	TAB1	11651	-0.02	0.34	NO
24	PPP2CA	PPP2CA	PPP2CA	11807	-0.023	0.34	NO
25	CSNK1A1	CSNK1A1	CSNK1A1	12165	-0.029	0.33	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NKD2	NKD2	NKD2	19	0.77	0.034	YES
2	SFRP5	SFRP5	SFRP5	44	0.69	0.064	YES
3	VANGL2	VANGL2	VANGL2	77	0.65	0.091	YES
4	CCND2	CCND2	CCND2	97	0.62	0.12	YES
5	APC2	APC2	APC2	101	0.62	0.15	YES
6	FZD10	FZD10	FZD10	111	0.61	0.17	YES
7	WIF1	WIF1	WIF1	187	0.55	0.19	YES
8	WNT5A	WNT5A	WNT5A	191	0.55	0.22	YES
9	FZD9	FZD9	FZD9	271	0.52	0.24	YES
10	CXXC4	CXXC4	CXXC4	334	0.49	0.26	YES
11	PRICKLE1	PRICKLE1	PRICKLE1	380	0.48	0.28	YES
12	FZD2	FZD2	FZD2	490	0.45	0.29	YES
13	FZD3	FZD3	FZD3	500	0.44	0.31	YES
14	LEF1	LEF1	LEF1	646	0.41	0.32	YES
15	WNT11	WNT11	WNT11	688	0.4	0.34	YES
16	NKD1	NKD1	NKD1	710	0.39	0.35	YES
17	FZD8	FZD8	FZD8	861	0.37	0.36	YES
18	RAC3	RAC3	RAC3	901	0.36	0.37	YES
19	DAAM2	DAAM2	DAAM2	969	0.35	0.39	YES
20	CAMK2B	CAMK2B	CAMK2B	1028	0.34	0.4	YES
21	WNT4	WNT4	WNT4	1060	0.34	0.41	YES
22	WNT3A	WNT3A	WNT3A	1093	0.33	0.42	YES
23	LRP5	LRP5	LRP5	1136	0.33	0.44	YES
24	WNT6	WNT6	WNT6	1197	0.32	0.45	YES
25	WNT5B	WNT5B	WNT5B	1526	0.28	0.44	YES
26	DKK2	DKK2	DKK2	1550	0.28	0.45	YES
27	WNT7A	WNT7A	WNT7A	1564	0.28	0.47	YES
28	LRP6	LRP6	LRP6	1612	0.27	0.48	YES
29	CCND1	CCND1	CCND1	1616	0.27	0.49	YES
30	SFRP1	SFRP1	SFRP1	1714	0.26	0.5	YES
31	WNT7B	WNT7B	WNT7B	1744	0.26	0.5	YES
32	FZD1	FZD1	FZD1	2068	0.23	0.5	YES
33	CER1	CER1	CER1	2142	0.23	0.5	YES
34	BTRC	BTRC	BTRC	2246	0.22	0.51	YES
35	TP53	TP53	TP53	2289	0.22	0.52	YES
36	SFRP2	SFRP2	SFRP2	2415	0.21	0.52	YES
37	CHP2	CHP2	CHP2	2427	0.2	0.53	YES
38	CTNNBIP1	CTNNBIP1	CTNNBIP1	3076	0.17	0.5	NO
39	NFATC2	NFATC2	NFATC2	3281	0.16	0.49	NO
40	TCF7L1	TCF7L1	TCF7L1	3300	0.16	0.5	NO
41	WNT3	WNT3	WNT3	3333	0.16	0.5	NO
42	WNT16	WNT16	WNT16	3868	0.13	0.48	NO
43	PRKCG	PRKCG	PRKCG	3939	0.13	0.48	NO
44	MAPK8	MAPK8	MAPK8	4076	0.12	0.48	NO
45	FZD4	FZD4	FZD4	4114	0.12	0.48	NO
46	NFATC4	NFATC4	NFATC4	4399	0.12	0.47	NO
47	FZD7	FZD7	FZD7	4448	0.11	0.48	NO
48	TCF7L2	TCF7L2	TCF7L2	4451	0.11	0.48	NO
49	AXIN2	AXIN2	AXIN2	4653	0.11	0.48	NO
50	NFAT5	NFAT5	NFAT5	4988	0.098	0.46	NO
51	CSNK2A1	CSNK2A1	CSNK2A1	4996	0.098	0.47	NO
52	SENP2	SENP2	SENP2	5079	0.095	0.46	NO
53	MMP7	MMP7	MMP7	5129	0.094	0.47	NO
54	NFATC3	NFATC3	NFATC3	5169	0.093	0.47	NO
55	PPP3CA	PPP3CA	PPP3CA	5218	0.092	0.47	NO
56	PRKX	PRKX	PRKX	5224	0.091	0.47	NO
57	APC	APC	APC	5248	0.091	0.48	NO
58	CTBP2	CTBP2	CTBP2	5508	0.085	0.47	NO
59	PPP3CB	PPP3CB	PPP3CB	5637	0.081	0.46	NO
60	CHD8	CHD8	CHD8	5672	0.081	0.46	NO
61	PPP2R1B	PPP2R1B	PPP2R1B	5766	0.079	0.46	NO
62	MAPK10	MAPK10	MAPK10	5813	0.078	0.46	NO
63	PPARD	PPARD	PPARD	5860	0.077	0.46	NO
64	WNT10A	WNT10A	WNT10A	5905	0.076	0.47	NO
65	CSNK1E	CSNK1E	CSNK1E	5907	0.076	0.47	NO
66	MAP3K7	MAP3K7	MAP3K7	5929	0.075	0.47	NO
67	NFATC1	NFATC1	NFATC1	5979	0.074	0.47	NO
68	WNT9A	WNT9A	WNT9A	6088	0.072	0.47	NO
69	PRKCA	PRKCA	PRKCA	6161	0.071	0.47	NO
70	WNT10B	WNT10B	WNT10B	6327	0.067	0.46	NO
71	CSNK2A2	CSNK2A2	CSNK2A2	6360	0.067	0.46	NO
72	DVL2	DVL2	DVL2	6382	0.066	0.47	NO
73	CTNNB1	CTNNB1	CTNNB1	6463	0.065	0.46	NO
74	TBL1XR1	TBL1XR1	TBL1XR1	6829	0.058	0.45	NO
75	EP300	EP300	EP300	6914	0.056	0.44	NO
76	PLCB4	PLCB4	PLCB4	7045	0.054	0.44	NO
77	DVL1	DVL1	DVL1	7590	0.044	0.41	NO
78	CTBP1	CTBP1	CTBP1	7673	0.043	0.41	NO
79	PPP2R1A	PPP2R1A	PPP2R1A	7734	0.042	0.41	NO
80	JUN	JUN	JUN	7909	0.039	0.4	NO
81	PPP3R1	PPP3R1	PPP3R1	7994	0.037	0.4	NO
82	CREBBP	CREBBP	CREBBP	8008	0.036	0.4	NO
83	FBXW11	FBXW11	FBXW11	8241	0.033	0.39	NO
84	CCND3	CCND3	CCND3	8364	0.031	0.38	NO
85	PSEN1	PSEN1	PSEN1	8390	0.031	0.38	NO
86	PRICKLE2	PRICKLE2	PRICKLE2	8464	0.03	0.38	NO
87	FRAT2	FRAT2	FRAT2	8468	0.029	0.38	NO
88	SMAD2	SMAD2	SMAD2	8613	0.027	0.37	NO
89	MYC	MYC	MYC	8791	0.025	0.36	NO
90	WNT8B	WNT8B	WNT8B	8794	0.024	0.36	NO
91	DVL3	DVL3	DVL3	8859	0.024	0.36	NO
92	SIAH1	SIAH1	SIAH1	9053	0.021	0.35	NO
93	CSNK1A1L	CSNK1A1L	CSNK1A1L	9058	0.021	0.35	NO
94	PRKACG	PRKACG	PRKACG	9099	0.02	0.35	NO
95	PPP2R5D	PPP2R5D	PPP2R5D	9259	0.018	0.34	NO
96	ROCK2	ROCK2	ROCK2	9338	0.016	0.34	NO
97	TCF7	TCF7	TCF7	9434	0.015	0.34	NO
98	FZD5	FZD5	FZD5	9559	0.013	0.33	NO
99	CSNK2B	CSNK2B	CSNK2B	9790	0.0093	0.32	NO
100	WNT1	WNT1	WNT1	9814	0.0088	0.32	NO
101	NLK	NLK	NLK	10092	0.0046	0.3	NO
102	SMAD4	SMAD4	SMAD4	10148	0.0038	0.3	NO
103	SKP1	SKP1	SKP1	10465	-0.00083	0.28	NO
104	PPP2R5C	PPP2R5C	PPP2R5C	10699	-0.0046	0.27	NO
105	CHP	CHP	CHP	10714	-0.0048	0.27	NO
106	PPP2CB	PPP2CB	PPP2CB	10813	-0.0067	0.26	NO
107	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.25	NO
108	RAC1	RAC1	RAC1	11146	-0.012	0.24	NO
109	PPP3R2	PPP3R2	PPP3R2	11161	-0.012	0.24	NO
110	FRAT1	FRAT1	FRAT1	11297	-0.014	0.24	NO
111	CUL1	CUL1	CUL1	11546	-0.018	0.22	NO
112	AXIN1	AXIN1	AXIN1	11595	-0.019	0.22	NO
113	PPP2CA	PPP2CA	PPP2CA	11807	-0.023	0.21	NO
114	CAMK2D	CAMK2D	CAMK2D	11825	-0.023	0.21	NO
115	TBL1X	TBL1X	TBL1X	12162	-0.029	0.2	NO
116	CSNK1A1	CSNK1A1	CSNK1A1	12165	-0.029	0.2	NO
117	PRKACA	PRKACA	PRKACA	12219	-0.03	0.19	NO
118	SMAD3	SMAD3	SMAD3	12248	-0.03	0.19	NO
119	WNT2B	WNT2B	WNT2B	12288	-0.031	0.19	NO
120	RBX1	RBX1	RBX1	12669	-0.038	0.17	NO
121	RUVBL1	RUVBL1	RUVBL1	12854	-0.042	0.17	NO
122	PPP2R5E	PPP2R5E	PPP2R5E	13001	-0.045	0.16	NO
123	MAPK9	MAPK9	MAPK9	13010	-0.045	0.16	NO
124	CACYBP	CACYBP	CACYBP	13077	-0.047	0.16	NO
125	VANGL1	VANGL1	VANGL1	13400	-0.054	0.14	NO
126	PLCB3	PLCB3	PLCB3	13669	-0.061	0.13	NO
127	RHOA	RHOA	RHOA	13768	-0.063	0.13	NO
128	PLCB1	PLCB1	PLCB1	14226	-0.076	0.11	NO
129	SOX17	SOX17	SOX17	14239	-0.076	0.11	NO
130	PPP3CC	PPP3CC	PPP3CC	14371	-0.08	0.11	NO
131	DAAM1	DAAM1	DAAM1	14382	-0.081	0.11	NO
132	PRKACB	PRKACB	PRKACB	14524	-0.085	0.11	NO
133	DKK1	DKK1	DKK1	14537	-0.086	0.11	NO
134	WNT2	WNT2	WNT2	14689	-0.091	0.1	NO
135	PORCN	PORCN	PORCN	14702	-0.091	0.11	NO
136	PLCB2	PLCB2	PLCB2	14904	-0.1	0.1	NO
137	ROCK1	ROCK1	ROCK1	14953	-0.1	0.1	NO
138	CAMK2G	CAMK2G	CAMK2G	15114	-0.11	0.1	NO
139	SFRP4	SFRP4	SFRP4	15378	-0.12	0.09	NO
140	PPP2R5A	PPP2R5A	PPP2R5A	15402	-0.12	0.095	NO
141	FOSL1	FOSL1	FOSL1	15808	-0.14	0.078	NO
142	CAMK2A	CAMK2A	CAMK2A	16218	-0.17	0.063	NO
143	WNT9B	WNT9B	WNT9B	16799	-0.22	0.041	NO
144	FZD6	FZD6	FZD6	16813	-0.22	0.05	NO
145	RAC2	RAC2	RAC2	17128	-0.26	0.045	NO
146	PRKCB	PRKCB	PRKCB	17318	-0.29	0.047	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CCND2	CCND2	CCND2	97	0.62	0.043	YES
2	WIF1	WIF1	WIF1	187	0.55	0.08	YES
3	WNT5A	WNT5A	WNT5A	191	0.55	0.12	YES
4	CXXC4	CXXC4	CXXC4	334	0.49	0.15	YES
5	FZD2	FZD2	FZD2	490	0.45	0.18	YES
6	FZD3	FZD3	FZD3	500	0.44	0.21	YES
7	LEF1	LEF1	LEF1	646	0.41	0.24	YES
8	WNT11	WNT11	WNT11	688	0.4	0.26	YES
9	NKD1	NKD1	NKD1	710	0.39	0.29	YES
10	FZD8	FZD8	FZD8	861	0.37	0.31	YES
11	WNT4	WNT4	WNT4	1060	0.34	0.33	YES
12	LRP5	LRP5	LRP5	1136	0.33	0.35	YES
13	WNT6	WNT6	WNT6	1197	0.32	0.37	YES
14	TLE1	TLE1	TLE1	1241	0.31	0.39	YES
15	WNT5B	WNT5B	WNT5B	1526	0.28	0.4	YES
16	WNT7A	WNT7A	WNT7A	1564	0.28	0.42	YES
17	LRP6	LRP6	LRP6	1612	0.27	0.44	YES
18	CCND1	CCND1	CCND1	1616	0.27	0.46	YES
19	SFRP1	SFRP1	SFRP1	1714	0.26	0.47	YES
20	WNT7B	WNT7B	WNT7B	1744	0.26	0.49	YES
21	BCL9	BCL9	BCL9	1916	0.24	0.5	YES
22	FZD1	FZD1	FZD1	2068	0.23	0.51	YES
23	BTRC	BTRC	BTRC	2246	0.22	0.52	YES
24	PYGO1	PYGO1	PYGO1	2462	0.2	0.52	YES
25	RHOU	RHOU	RHOU	2647	0.19	0.53	YES
26	PITX2	PITX2	PITX2	2808	0.18	0.53	YES
27	FRZB	FRZB	FRZB	2852	0.18	0.54	YES
28	CTNNBIP1	CTNNBIP1	CTNNBIP1	3076	0.17	0.55	YES
29	TCF7L1	TCF7L1	TCF7L1	3300	0.16	0.55	YES
30	WNT3	WNT3	WNT3	3333	0.16	0.56	YES
31	WNT16	WNT16	WNT16	3868	0.13	0.54	NO
32	TLE2	TLE2	TLE2	3887	0.13	0.55	NO
33	FZD4	FZD4	FZD4	4114	0.12	0.54	NO
34	FZD7	FZD7	FZD7	4448	0.11	0.53	NO
35	CSNK2A1	CSNK2A1	CSNK2A1	4996	0.098	0.51	NO
36	SENP2	SENP2	SENP2	5079	0.095	0.51	NO
37	APC	APC	APC	5248	0.091	0.51	NO
38	CTBP2	CTBP2	CTBP2	5508	0.085	0.5	NO
39	WNT10A	WNT10A	WNT10A	5905	0.076	0.49	NO
40	RPL13A	RPL13A	RPL13A	5961	0.075	0.49	NO
41	WNT9A	WNT9A	WNT9A	6088	0.072	0.49	NO
42	DVL2	DVL2	DVL2	6382	0.066	0.48	NO
43	CTNNB1	CTNNB1	CTNNB1	6463	0.065	0.48	NO
44	EP300	EP300	EP300	6914	0.056	0.46	NO
45	DVL1	DVL1	DVL1	7590	0.044	0.42	NO
46	CTBP1	CTBP1	CTBP1	7673	0.043	0.42	NO
47	PPP2R1A	PPP2R1A	PPP2R1A	7734	0.042	0.42	NO
48	CSNK1D	CSNK1D	CSNK1D	7827	0.04	0.42	NO
49	JUN	JUN	JUN	7909	0.039	0.42	NO
50	FBXW11	FBXW11	FBXW11	8241	0.033	0.4	NO
51	CCND3	CCND3	CCND3	8364	0.031	0.4	NO
52	FBXW4	FBXW4	FBXW4	8677	0.026	0.38	NO
53	CSNK1G1	CSNK1G1	CSNK1G1	8766	0.025	0.38	NO
54	MYC	MYC	MYC	8791	0.025	0.38	NO
55	TCF7	TCF7	TCF7	9434	0.015	0.35	NO
56	WISP1	WISP1	WISP1	9512	0.014	0.34	NO
57	FZD5	FZD5	FZD5	9559	0.013	0.34	NO
58	WNT1	WNT1	WNT1	9814	0.0088	0.33	NO
59	NLK	NLK	NLK	10092	0.0046	0.31	NO
60	T	T	T	10499	-0.0016	0.29	NO
61	GSK3A	GSK3A	GSK3A	10514	-0.0018	0.29	NO
62	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.26	NO
63	FBXW2	FBXW2	FBXW2	11114	-0.011	0.26	NO
64	FRAT1	FRAT1	FRAT1	11297	-0.014	0.25	NO
65	AXIN1	AXIN1	AXIN1	11595	-0.019	0.24	NO
66	PPP2CA	PPP2CA	PPP2CA	11807	-0.023	0.22	NO
67	CSNK1A1	CSNK1A1	CSNK1A1	12165	-0.029	0.21	NO
68	AES	AES	AES	12287	-0.031	0.2	NO
69	WNT2B	WNT2B	WNT2B	12288	-0.031	0.21	NO
70	KREMEN1	KREMEN1	KREMEN1	12666	-0.038	0.19	NO
71	GAPDH	GAPDH	GAPDH	13501	-0.056	0.15	NO
72	SLC9A3R1	SLC9A3R1	SLC9A3R1	13658	-0.06	0.14	NO
73	HPRT1	HPRT1	HPRT1	14052	-0.071	0.13	NO
74	SOX17	SOX17	SOX17	14239	-0.076	0.12	NO
75	DAAM1	DAAM1	DAAM1	14382	-0.081	0.12	NO
76	DKK1	DKK1	DKK1	14537	-0.086	0.12	NO
77	WNT2	WNT2	WNT2	14689	-0.091	0.12	NO
78	PORCN	PORCN	PORCN	14702	-0.091	0.12	NO
79	DIXDC1	DIXDC1	DIXDC1	14870	-0.098	0.12	NO
80	ACTB	ACTB	ACTB	15198	-0.11	0.11	NO
81	SFRP4	SFRP4	SFRP4	15378	-0.12	0.11	NO
82	FOSL1	FOSL1	FOSL1	15808	-0.14	0.098	NO
83	B2M	B2M	B2M	16510	-0.19	0.074	NO
84	FZD6	FZD6	FZD6	16813	-0.22	0.075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	APC2	APC2	APC2	101	0.62	0.046	YES
2	FZD10	FZD10	FZD10	111	0.61	0.096	YES
3	WNT5A	WNT5A	WNT5A	191	0.55	0.14	YES
4	HHIP	HHIP	HHIP	211	0.54	0.18	YES
5	SMO	SMO	SMO	215	0.54	0.22	YES
6	PTCH1	PTCH1	PTCH1	218	0.54	0.27	YES
7	FZD9	FZD9	FZD9	271	0.52	0.31	YES
8	BMP4	BMP4	BMP4	474	0.45	0.34	YES
9	FZD2	FZD2	FZD2	490	0.45	0.37	YES
10	FZD3	FZD3	FZD3	500	0.44	0.41	YES
11	LEF1	LEF1	LEF1	646	0.41	0.44	YES
12	WNT11	WNT11	WNT11	688	0.4	0.47	YES
13	GLI1	GLI1	GLI1	724	0.39	0.5	YES
14	FZD8	FZD8	FZD8	861	0.37	0.52	YES
15	GLI2	GLI2	GLI2	925	0.36	0.55	YES
16	WNT4	WNT4	WNT4	1060	0.34	0.57	YES
17	WNT6	WNT6	WNT6	1197	0.32	0.58	YES
18	BMP2	BMP2	BMP2	1480	0.29	0.59	YES
19	WNT5B	WNT5B	WNT5B	1526	0.28	0.61	YES
20	WNT7A	WNT7A	WNT7A	1564	0.28	0.64	YES
21	WNT7B	WNT7B	WNT7B	1744	0.26	0.65	YES
22	PTCH2	PTCH2	PTCH2	1885	0.25	0.66	YES
23	FZD1	FZD1	FZD1	2068	0.23	0.67	YES
24	TP53	TP53	TP53	2289	0.22	0.68	YES
25	SUFU	SUFU	SUFU	3240	0.16	0.64	NO
26	TCF7L1	TCF7L1	TCF7L1	3300	0.16	0.65	NO
27	WNT3	WNT3	WNT3	3333	0.16	0.66	NO
28	WNT16	WNT16	WNT16	3868	0.13	0.64	NO
29	FZD4	FZD4	FZD4	4114	0.12	0.64	NO
30	FZD7	FZD7	FZD7	4448	0.11	0.63	NO
31	TCF7L2	TCF7L2	TCF7L2	4451	0.11	0.64	NO
32	AXIN2	AXIN2	AXIN2	4653	0.11	0.63	NO
33	STK36	STK36	STK36	4753	0.1	0.64	NO
34	APC	APC	APC	5248	0.091	0.62	NO
35	GLI3	GLI3	GLI3	5834	0.077	0.59	NO
36	WNT10A	WNT10A	WNT10A	5905	0.076	0.59	NO
37	WNT9A	WNT9A	WNT9A	6088	0.072	0.59	NO
38	WNT10B	WNT10B	WNT10B	6327	0.067	0.58	NO
39	DVL2	DVL2	DVL2	6382	0.066	0.58	NO
40	CTNNB1	CTNNB1	CTNNB1	6463	0.065	0.59	NO
41	DVL1	DVL1	DVL1	7590	0.044	0.53	NO
42	WNT8B	WNT8B	WNT8B	8794	0.024	0.46	NO
43	DVL3	DVL3	DVL3	8859	0.024	0.46	NO
44	TCF7	TCF7	TCF7	9434	0.015	0.43	NO
45	FZD5	FZD5	FZD5	9559	0.013	0.42	NO
46	WNT1	WNT1	WNT1	9814	0.0088	0.41	NO
47	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.35	NO
48	AXIN1	AXIN1	AXIN1	11595	-0.019	0.32	NO
49	WNT2B	WNT2B	WNT2B	12288	-0.031	0.28	NO
50	WNT2	WNT2	WNT2	14689	-0.091	0.16	NO
51	WNT9B	WNT9B	WNT9B	16799	-0.22	0.057	NO
52	FZD6	FZD6	FZD6	16813	-0.22	0.075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	EFNB3	EFNB3	EFNB3	10	0.81	0.037	YES
2	EFNA2	EFNA2	EFNA2	12	0.8	0.074	YES
3	SEMA4G	SEMA4G	SEMA4G	38	0.7	0.1	YES
4	LRRC4C	LRRC4C	LRRC4C	112	0.61	0.13	YES
5	SEMA4F	SEMA4F	SEMA4F	160	0.57	0.15	YES
6	EPHB3	EPHB3	EPHB3	180	0.56	0.18	YES
7	SRGAP3	SRGAP3	SRGAP3	193	0.55	0.2	YES
8	SLIT1	SLIT1	SLIT1	207	0.54	0.23	YES
9	SEMA6D	SEMA6D	SEMA6D	276	0.52	0.25	YES
10	ROBO2	ROBO2	ROBO2	361	0.48	0.26	YES
11	SEMA6A	SEMA6A	SEMA6A	366	0.48	0.28	YES
12	EPHA3	EPHA3	EPHA3	580	0.42	0.29	YES
13	SEMA3A	SEMA3A	SEMA3A	764	0.38	0.3	YES
14	EFNA3	EFNA3	EFNA3	792	0.38	0.32	YES
15	NTN3	NTN3	NTN3	808	0.38	0.33	YES
16	RAC3	RAC3	RAC3	901	0.36	0.34	YES
17	EFNA4	EFNA4	EFNA4	1160	0.32	0.34	YES
18	DCC	DCC	DCC	1169	0.32	0.36	YES
19	EPHA8	EPHA8	EPHA8	1314	0.31	0.37	YES
20	SLIT2	SLIT2	SLIT2	1379	0.3	0.38	YES
21	UNC5B	UNC5B	UNC5B	1409	0.29	0.39	YES
22	EPHA2	EPHA2	EPHA2	1544	0.28	0.39	YES
23	SEMA7A	SEMA7A	SEMA7A	1561	0.28	0.41	YES
24	SEMA3D	SEMA3D	SEMA3D	1771	0.26	0.41	YES
25	SEMA6C	SEMA6C	SEMA6C	1825	0.25	0.42	YES
26	EPHB2	EPHB2	EPHB2	1852	0.25	0.42	YES
27	EPHA4	EPHA4	EPHA4	1963	0.24	0.43	YES
28	SEMA5B	SEMA5B	SEMA5B	2052	0.23	0.44	YES
29	EFNA1	EFNA1	EFNA1	2073	0.23	0.44	YES
30	NGEF	NGEF	NGEF	2080	0.23	0.46	YES
31	DPYSL5	DPYSL5	DPYSL5	2120	0.23	0.46	YES
32	NTN1	NTN1	NTN1	2308	0.21	0.46	YES
33	CHP2	CHP2	CHP2	2427	0.2	0.47	YES
34	PLXNA3	PLXNA3	PLXNA3	2431	0.2	0.48	YES
35	L1CAM	L1CAM	L1CAM	2579	0.2	0.48	YES
36	SLIT3	SLIT3	SLIT3	2615	0.19	0.48	YES
37	NTNG1	NTNG1	NTNG1	2788	0.18	0.48	YES
38	UNC5C	UNC5C	UNC5C	2798	0.18	0.49	YES
39	EFNB1	EFNB1	EFNB1	2907	0.18	0.49	YES
40	EPHB4	EPHB4	EPHB4	2938	0.18	0.5	YES
41	EPHA5	EPHA5	EPHA5	3016	0.17	0.5	YES
42	GNAI1	GNAI1	GNAI1	3051	0.17	0.51	YES
43	NFATC2	NFATC2	NFATC2	3281	0.16	0.5	YES
44	RND1	RND1	RND1	3297	0.16	0.51	YES
45	EFNB2	EFNB2	EFNB2	3341	0.16	0.51	YES
46	SEMA5A	SEMA5A	SEMA5A	3434	0.15	0.52	YES
47	SEMA3B	SEMA3B	SEMA3B	3508	0.15	0.52	YES
48	EPHB1	EPHB1	EPHB1	3591	0.14	0.52	YES
49	EPHA7	EPHA7	EPHA7	3719	0.14	0.52	YES
50	LIMK1	LIMK1	LIMK1	3838	0.13	0.52	YES
51	ROBO1	ROBO1	ROBO1	3910	0.13	0.52	YES
52	PAK7	PAK7	PAK7	4095	0.12	0.52	YES
53	NCK2	NCK2	NCK2	4097	0.12	0.52	YES
54	SEMA4C	SEMA4C	SEMA4C	4353	0.12	0.52	YES
55	NFATC4	NFATC4	NFATC4	4399	0.12	0.52	YES
56	ABLIM1	ABLIM1	ABLIM1	4488	0.11	0.52	YES
57	SEMA3F	SEMA3F	SEMA3F	4614	0.11	0.52	YES
58	UNC5A	UNC5A	UNC5A	4660	0.11	0.52	YES
59	PAK6	PAK6	PAK6	4775	0.1	0.52	YES
60	SEMA3E	SEMA3E	SEMA3E	4819	0.1	0.52	YES
61	EFNA5	EFNA5	EFNA5	4905	0.1	0.52	YES
62	NRAS	NRAS	NRAS	4933	0.1	0.52	YES
63	NFAT5	NFAT5	NFAT5	4988	0.098	0.52	YES
64	UNC5D	UNC5D	UNC5D	4990	0.098	0.53	YES
65	NFATC3	NFATC3	NFATC3	5169	0.093	0.52	YES
66	RASA1	RASA1	RASA1	5194	0.092	0.53	YES
67	PPP3CA	PPP3CA	PPP3CA	5218	0.092	0.53	YES
68	PLXNB2	PLXNB2	PLXNB2	5293	0.089	0.53	YES
69	KRAS	KRAS	KRAS	5307	0.089	0.53	YES
70	RGS3	RGS3	RGS3	5467	0.086	0.53	NO
71	PPP3CB	PPP3CB	PPP3CB	5637	0.081	0.52	NO
72	MET	MET	MET	5776	0.078	0.52	NO
73	SRGAP2	SRGAP2	SRGAP2	5947	0.075	0.51	NO
74	NFATC1	NFATC1	NFATC1	5979	0.074	0.51	NO
75	PAK4	PAK4	PAK4	6838	0.058	0.47	NO
76	PTK2	PTK2	PTK2	7512	0.046	0.43	NO
77	SEMA6B	SEMA6B	SEMA6B	7682	0.042	0.43	NO
78	PLXNA1	PLXNA1	PLXNA1	7738	0.042	0.42	NO
79	RHOD	RHOD	RHOD	7765	0.041	0.42	NO
80	PPP3R1	PPP3R1	PPP3R1	7994	0.037	0.41	NO
81	CDK5	CDK5	CDK5	8201	0.034	0.4	NO
82	CXCR4	CXCR4	CXCR4	8327	0.032	0.4	NO
83	SRGAP1	SRGAP1	SRGAP1	8440	0.03	0.39	NO
84	PLXNA2	PLXNA2	PLXNA2	9229	0.018	0.35	NO
85	ROBO3	ROBO3	ROBO3	9236	0.018	0.35	NO
86	ARHGEF12	ARHGEF12	ARHGEF12	9275	0.017	0.35	NO
87	ROCK2	ROCK2	ROCK2	9338	0.016	0.35	NO
88	SEMA4D	SEMA4D	SEMA4D	9709	0.01	0.33	NO
89	GNAI3	GNAI3	GNAI3	9853	0.0082	0.32	NO
90	CXCL12	CXCL12	CXCL12	10532	-0.002	0.28	NO
91	CHP	CHP	CHP	10714	-0.0048	0.27	NO
92	NRP1	NRP1	NRP1	10996	-0.0092	0.26	NO
93	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.26	NO
94	ABL1	ABL1	ABL1	11071	-0.01	0.26	NO
95	RAC1	RAC1	RAC1	11146	-0.012	0.25	NO
96	PPP3R2	PPP3R2	PPP3R2	11161	-0.012	0.25	NO
97	CDC42	CDC42	CDC42	11395	-0.016	0.24	NO
98	PAK2	PAK2	PAK2	11727	-0.021	0.22	NO
99	PLXNC1	PLXNC1	PLXNC1	11884	-0.024	0.21	NO
100	PAK3	PAK3	PAK3	12026	-0.026	0.21	NO
101	MAPK1	MAPK1	MAPK1	12177	-0.029	0.2	NO
102	LIMK2	LIMK2	LIMK2	12305	-0.031	0.2	NO
103	EPHA6	EPHA6	EPHA6	12323	-0.032	0.2	NO
104	MAPK3	MAPK3	MAPK3	12476	-0.035	0.19	NO
105	DPYSL2	DPYSL2	DPYSL2	12488	-0.035	0.19	NO
106	EPHB6	EPHB6	EPHB6	13043	-0.046	0.16	NO
107	PAK1	PAK1	PAK1	13140	-0.048	0.16	NO
108	CFL1	CFL1	CFL1	13325	-0.052	0.15	NO
109	PLXNB1	PLXNB1	PLXNB1	13571	-0.058	0.14	NO
110	FYN	FYN	FYN	13620	-0.059	0.14	NO
111	RHOA	RHOA	RHOA	13768	-0.063	0.13	NO
112	PLXNB3	PLXNB3	PLXNB3	13978	-0.069	0.12	NO
113	ITGB1	ITGB1	ITGB1	13998	-0.069	0.13	NO
114	NCK1	NCK1	NCK1	14120	-0.073	0.12	NO
115	GNAI2	GNAI2	GNAI2	14164	-0.074	0.12	NO
116	SEMA4B	SEMA4B	SEMA4B	14276	-0.078	0.12	NO
117	PPP3CC	PPP3CC	PPP3CC	14371	-0.08	0.12	NO
118	ROCK1	ROCK1	ROCK1	14953	-0.1	0.094	NO
119	NTN4	NTN4	NTN4	15442	-0.12	0.072	NO
120	ABLIM2	ABLIM2	ABLIM2	15517	-0.13	0.074	NO
121	SEMA3G	SEMA3G	SEMA3G	15671	-0.13	0.072	NO
122	EPHA1	EPHA1	EPHA1	15713	-0.14	0.076	NO
123	FES	FES	FES	16178	-0.17	0.058	NO
124	SEMA3C	SEMA3C	SEMA3C	16206	-0.17	0.064	NO
125	ABLIM3	ABLIM3	ABLIM3	16614	-0.2	0.05	NO
126	SEMA4A	SEMA4A	SEMA4A	16687	-0.21	0.056	NO
127	RAC2	RAC2	RAC2	17128	-0.26	0.044	NO
128	CFL2	CFL2	CFL2	17411	-0.3	0.042	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HS3ST3B1	HS3ST3B1	HS3ST3B1	629	0.41	0.056	YES
2	EXTL1	EXTL1	EXTL1	674	0.4	0.14	YES
3	HS6ST2	HS6ST2	HS6ST2	760	0.38	0.22	YES
4	NDST3	NDST3	NDST3	782	0.38	0.3	YES
5	HS3ST3A1	HS3ST3A1	HS3ST3A1	908	0.36	0.38	YES
6	HS3ST5	HS3ST5	HS3ST5	1195	0.32	0.43	YES
7	B3GAT1	B3GAT1	B3GAT1	1362	0.3	0.49	YES
8	NDST4	NDST4	NDST4	1594	0.28	0.54	YES
9	GLCE	GLCE	GLCE	1882	0.25	0.58	YES
10	EXTL2	EXTL2	EXTL2	2211	0.22	0.61	YES
11	B3GALT6	B3GALT6	B3GALT6	3155	0.16	0.59	YES
12	HS6ST1	HS6ST1	HS6ST1	3448	0.15	0.61	YES
13	XYLT2	XYLT2	XYLT2	4725	0.11	0.56	NO
14	EXT2	EXT2	EXT2	5340	0.089	0.55	NO
15	NDST1	NDST1	NDST1	5727	0.08	0.54	NO
16	HS3ST1	HS3ST1	HS3ST1	6885	0.057	0.49	NO
17	NDST2	NDST2	NDST2	7114	0.053	0.49	NO
18	B4GALT7	B4GALT7	B4GALT7	7284	0.05	0.49	NO
19	B3GAT3	B3GAT3	B3GAT3	8947	0.022	0.41	NO
20	HS2ST1	HS2ST1	HS2ST1	9572	0.012	0.37	NO
21	EXT1	EXT1	EXT1	11296	-0.014	0.28	NO
22	HS6ST3	HS6ST3	HS6ST3	12702	-0.039	0.21	NO
23	B3GAT2	B3GAT2	B3GAT2	12944	-0.044	0.21	NO
24	XYLT1	XYLT1	XYLT1	15051	-0.1	0.12	NO
25	HS3ST2	HS3ST2	HS3ST2	17067	-0.25	0.061	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BMP7	BMP7	BMP7	140	0.58	0.044	YES
2	WNT5A	WNT5A	WNT5A	191	0.55	0.09	YES
3	HHIP	HHIP	HHIP	211	0.54	0.14	YES
4	SMO	SMO	SMO	215	0.54	0.18	YES
5	PTCH1	PTCH1	PTCH1	218	0.54	0.23	YES
6	BMP5	BMP5	BMP5	221	0.54	0.28	YES
7	ZIC2	ZIC2	ZIC2	396	0.48	0.31	YES
8	BMP4	BMP4	BMP4	474	0.45	0.35	YES
9	WNT11	WNT11	WNT11	688	0.4	0.37	YES
10	GLI1	GLI1	GLI1	724	0.39	0.41	YES
11	GLI2	GLI2	GLI2	925	0.36	0.43	YES
12	WNT4	WNT4	WNT4	1060	0.34	0.45	YES
13	LRP2	LRP2	LRP2	1168	0.32	0.47	YES
14	WNT6	WNT6	WNT6	1197	0.32	0.5	YES
15	BMP2	BMP2	BMP2	1480	0.29	0.51	YES
16	IHH	IHH	IHH	1505	0.28	0.53	YES
17	WNT5B	WNT5B	WNT5B	1526	0.28	0.56	YES
18	WNT7A	WNT7A	WNT7A	1564	0.28	0.58	YES
19	BMP6	BMP6	BMP6	1705	0.26	0.6	YES
20	WNT7B	WNT7B	WNT7B	1744	0.26	0.62	YES
21	PTCH2	PTCH2	PTCH2	1885	0.25	0.63	YES
22	BTRC	BTRC	BTRC	2246	0.22	0.63	NO
23	BMP8A	BMP8A	BMP8A	2822	0.18	0.61	NO
24	SUFU	SUFU	SUFU	3240	0.16	0.61	NO
25	WNT3	WNT3	WNT3	3333	0.16	0.61	NO
26	WNT16	WNT16	WNT16	3868	0.13	0.6	NO
27	STK36	STK36	STK36	4753	0.1	0.56	NO
28	CSNK1G3	CSNK1G3	CSNK1G3	4879	0.1	0.56	NO
29	BMP8B	BMP8B	BMP8B	5204	0.092	0.55	NO
30	PRKX	PRKX	PRKX	5224	0.091	0.56	NO
31	CSNK1G2	CSNK1G2	CSNK1G2	5258	0.09	0.56	NO
32	DHH	DHH	DHH	5710	0.08	0.55	NO
33	GLI3	GLI3	GLI3	5834	0.077	0.55	NO
34	WNT10A	WNT10A	WNT10A	5905	0.076	0.55	NO
35	CSNK1E	CSNK1E	CSNK1E	5907	0.076	0.56	NO
36	WNT9A	WNT9A	WNT9A	6088	0.072	0.55	NO
37	WNT10B	WNT10B	WNT10B	6327	0.067	0.54	NO
38	CSNK1D	CSNK1D	CSNK1D	7827	0.04	0.46	NO
39	FBXW11	FBXW11	FBXW11	8241	0.033	0.44	NO
40	CSNK1G1	CSNK1G1	CSNK1G1	8766	0.025	0.42	NO
41	WNT8B	WNT8B	WNT8B	8794	0.024	0.42	NO
42	CSNK1A1L	CSNK1A1L	CSNK1A1L	9058	0.021	0.41	NO
43	PRKACG	PRKACG	PRKACG	9099	0.02	0.41	NO
44	WNT1	WNT1	WNT1	9814	0.0088	0.37	NO
45	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.3	NO
46	CSNK1A1	CSNK1A1	CSNK1A1	12165	-0.029	0.24	NO
47	PRKACA	PRKACA	PRKACA	12219	-0.03	0.24	NO
48	WNT2B	WNT2B	WNT2B	12288	-0.031	0.24	NO
49	PRKACB	PRKACB	PRKACB	14524	-0.085	0.12	NO
50	WNT2	WNT2	WNT2	14689	-0.091	0.12	NO
51	GAS1	GAS1	GAS1	15347	-0.12	0.097	NO
52	WNT9B	WNT9B	WNT9B	16799	-0.22	0.037	NO
53	RAB23	RAB23	RAB23	17978	-0.44	0.01	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BMP7	BMP7	BMP7	140	0.58	0.093	YES
2	BMP5	BMP5	BMP5	221	0.54	0.18	YES
3	BMP4	BMP4	BMP4	474	0.45	0.24	YES
4	GATA4	GATA4	GATA4	486	0.45	0.32	YES
5	SMAD6	SMAD6	SMAD6	727	0.39	0.38	YES
6	TGFB2	TGFB2	TGFB2	731	0.39	0.44	YES
7	NOG	NOG	NOG	951	0.36	0.49	YES
8	BMP2	BMP2	BMP2	1480	0.29	0.51	YES
9	HNF1A	HNF1A	HNF1A	1712	0.26	0.54	YES
10	FZD1	FZD1	FZD1	2068	0.23	0.56	YES
11	SMAD1	SMAD1	SMAD1	3758	0.14	0.5	NO
12	ATF2	ATF2	ATF2	4000	0.13	0.5	NO
13	CHRD	CHRD	CHRD	4126	0.12	0.52	NO
14	SMAD5	SMAD5	SMAD5	4444	0.11	0.52	NO
15	BMPR2	BMPR2	BMPR2	5234	0.091	0.49	NO
16	APC	APC	APC	5248	0.091	0.51	NO
17	TGFB3	TGFB3	TGFB3	5333	0.089	0.52	NO
18	NKX2-5	NKX2-5	NKX2-5	5652	0.081	0.52	NO
19	BMPR1A	BMPR1A	BMPR1A	5893	0.076	0.52	NO
20	MAP3K7	MAP3K7	MAP3K7	5929	0.075	0.53	NO
21	NPPB	NPPB	NPPB	6205	0.07	0.52	NO
22	CTNNB1	CTNNB1	CTNNB1	6463	0.065	0.52	NO
23	DVL1	DVL1	DVL1	7590	0.044	0.46	NO
24	RFC1	RFC1	RFC1	8451	0.03	0.42	NO
25	WNT1	WNT1	WNT1	9814	0.0088	0.35	NO
26	SMAD4	SMAD4	SMAD4	10148	0.0038	0.33	NO
27	TGFBR1	TGFBR1	TGFBR1	10302	0.0014	0.32	NO
28	GSK3B	GSK3B	GSK3B	11019	-0.0096	0.29	NO
29	ACVR1	ACVR1	ACVR1	11439	-0.016	0.26	NO
30	AXIN1	AXIN1	AXIN1	11595	-0.019	0.26	NO
31	MYL2	MYL2	MYL2	13147	-0.048	0.18	NO
32	TGFBR2	TGFBR2	TGFBR2	15022	-0.1	0.098	NO
33	TGFB1	TGFB1	TGFB1	15532	-0.13	0.091	NO
34	TGFBR3	TGFBR3	TGFBR3	16035	-0.16	0.09	NO
35	NPPA	NPPA	NPPA	16063	-0.16	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GRM4	GRM4	GRM4	4	0.89	0.14	YES
2	ACCN1	ACCN1	ACCN1	172	0.56	0.22	YES
3	TRPM5	TRPM5	TRPM5	576	0.42	0.27	YES
4	CACNA1B	CACNA1B	CACNA1B	823	0.37	0.31	YES
5	TAS2R19	TAS2R19	TAS2R19	1044	0.34	0.35	YES
6	TAS2R5	TAS2R5	TAS2R5	1372	0.3	0.38	YES
7	TAS2R10	TAS2R10	TAS2R10	1684	0.27	0.41	YES
8	TAS2R4	TAS2R4	TAS2R4	1941	0.24	0.43	YES
9	CACNA1A	CACNA1A	CACNA1A	2005	0.24	0.47	YES
10	SCNN1G	SCNN1G	SCNN1G	2019	0.24	0.5	YES
11	TAS2R31	TAS2R31	TAS2R31	2143	0.23	0.53	YES
12	TAS1R3	TAS1R3	TAS1R3	2465	0.2	0.55	YES
13	TAS2R14	TAS2R14	TAS2R14	2480	0.2	0.58	YES
14	TAS2R13	TAS2R13	TAS2R13	2528	0.2	0.61	YES
15	ADCY6	ADCY6	ADCY6	3073	0.17	0.6	YES
16	TAS1R1	TAS1R1	TAS1R1	3378	0.15	0.61	YES
17	GNB3	GNB3	GNB3	3536	0.15	0.63	YES
18	GNG3	GNG3	GNG3	4116	0.12	0.61	NO
19	TAS2R20	TAS2R20	TAS2R20	4380	0.12	0.62	NO
20	TAS2R46	TAS2R46	TAS2R46	5172	0.093	0.59	NO
21	PRKX	PRKX	PRKX	5224	0.091	0.6	NO
22	GNAS	GNAS	GNAS	5624	0.082	0.59	NO
23	TAS2R43	TAS2R43	TAS2R43	7958	0.038	0.47	NO
24	GNB1	GNB1	GNB1	8609	0.027	0.44	NO
25	PRKACG	PRKACG	PRKACG	9099	0.02	0.41	NO
26	ADCY4	ADCY4	ADCY4	9976	0.0064	0.37	NO
27	SCNN1A	SCNN1A	SCNN1A	10413	-3e-05	0.34	NO
28	ITPR3	ITPR3	ITPR3	10856	-0.0072	0.32	NO
29	SCNN1B	SCNN1B	SCNN1B	11975	-0.026	0.26	NO
30	PRKACA	PRKACA	PRKACA	12219	-0.03	0.25	NO
31	KCNB1	KCNB1	KCNB1	12901	-0.043	0.22	NO
32	PRKACB	PRKACB	PRKACB	14524	-0.085	0.15	NO
33	PLCB2	PLCB2	PLCB2	14904	-0.1	0.14	NO
34	ADCY8	ADCY8	ADCY8	15125	-0.11	0.15	NO
35	PDE1A	PDE1A	PDE1A	15675	-0.13	0.14	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BMP7	BMP7	BMP7	140	0.58	0.043	YES
2	BMP5	BMP5	BMP5	221	0.54	0.084	YES
3	E2F5	E2F5	E2F5	231	0.53	0.13	YES
4	GDF7	GDF7	GDF7	408	0.47	0.16	YES
5	BMP4	BMP4	BMP4	474	0.45	0.2	YES
6	SMAD9	SMAD9	SMAD9	553	0.43	0.23	YES
7	ID1	ID1	ID1	578	0.42	0.26	YES
8	SMAD6	SMAD6	SMAD6	727	0.39	0.29	YES
9	TGFB2	TGFB2	TGFB2	731	0.39	0.32	YES
10	ID3	ID3	ID3	1403	0.3	0.31	YES
11	BMP2	BMP2	BMP2	1480	0.29	0.33	YES
12	COMP	COMP	COMP	1522	0.28	0.35	YES
13	BMP6	BMP6	BMP6	1705	0.26	0.37	YES
14	INHBC	INHBC	INHBC	1854	0.25	0.38	YES
15	GDF6	GDF6	GDF6	1906	0.25	0.4	YES
16	THBS4	THBS4	THBS4	2773	0.18	0.37	YES
17	PITX2	PITX2	PITX2	2808	0.18	0.38	YES
18	BMP8A	BMP8A	BMP8A	2822	0.18	0.39	YES
19	ZFYVE9	ZFYVE9	ZFYVE9	2848	0.18	0.41	YES
20	NODAL	NODAL	NODAL	3156	0.16	0.41	YES
21	INHBE	INHBE	INHBE	3157	0.16	0.42	YES
22	INHBB	INHBB	INHBB	3311	0.16	0.42	YES
23	SMAD7	SMAD7	SMAD7	3714	0.14	0.42	YES
24	SMAD1	SMAD1	SMAD1	3758	0.14	0.42	YES
25	ACVR2A	ACVR2A	ACVR2A	3781	0.14	0.43	YES
26	CHRD	CHRD	CHRD	4126	0.12	0.43	YES
27	ACVR2B	ACVR2B	ACVR2B	4343	0.12	0.42	YES
28	SMAD5	SMAD5	SMAD5	4444	0.11	0.43	YES
29	AMH	AMH	AMH	4457	0.11	0.44	YES
30	ZFYVE16	ZFYVE16	ZFYVE16	4691	0.11	0.43	YES
31	INHBA	INHBA	INHBA	4899	0.1	0.43	YES
32	BMP8B	BMP8B	BMP8B	5204	0.092	0.42	YES
33	BMPR2	BMPR2	BMPR2	5234	0.091	0.43	YES
34	TGFB3	TGFB3	TGFB3	5333	0.089	0.43	YES
35	ID2	ID2	ID2	5358	0.088	0.44	YES
36	ID4	ID4	ID4	5396	0.088	0.44	YES
37	BMPR1B	BMPR1B	BMPR1B	5501	0.085	0.44	YES
38	AMHR2	AMHR2	AMHR2	5703	0.08	0.44	NO
39	PPP2R1B	PPP2R1B	PPP2R1B	5766	0.079	0.44	NO
40	BMPR1A	BMPR1A	BMPR1A	5893	0.076	0.44	NO
41	RPS6KB1	RPS6KB1	RPS6KB1	6368	0.066	0.42	NO
42	THBS3	THBS3	THBS3	6476	0.064	0.42	NO
43	RBL2	RBL2	RBL2	6777	0.059	0.41	NO
44	EP300	EP300	EP300	6914	0.056	0.41	NO
45	LEFTY2	LEFTY2	LEFTY2	7012	0.054	0.41	NO
46	DCN	DCN	DCN	7542	0.045	0.38	NO
47	PPP2R1A	PPP2R1A	PPP2R1A	7734	0.042	0.38	NO
48	CREBBP	CREBBP	CREBBP	8008	0.036	0.36	NO
49	SP1	SP1	SP1	8356	0.031	0.35	NO
50	GDF5	GDF5	GDF5	8482	0.029	0.34	NO
51	SMAD2	SMAD2	SMAD2	8613	0.027	0.34	NO
52	MYC	MYC	MYC	8791	0.025	0.33	NO
53	SMURF1	SMURF1	SMURF1	9133	0.02	0.31	NO
54	E2F4	E2F4	E2F4	9165	0.019	0.31	NO
55	ROCK2	ROCK2	ROCK2	9338	0.016	0.3	NO
56	SMURF2	SMURF2	SMURF2	10072	0.005	0.26	NO
57	SMAD4	SMAD4	SMAD4	10148	0.0038	0.26	NO
58	TGFBR1	TGFBR1	TGFBR1	10302	0.0014	0.25	NO
59	SKP1	SKP1	SKP1	10465	-0.00083	0.24	NO
60	FST	FST	FST	10805	-0.0065	0.22	NO
61	PPP2CB	PPP2CB	PPP2CB	10813	-0.0067	0.22	NO
62	LEFTY1	LEFTY1	LEFTY1	11045	-0.0099	0.21	NO
63	ACVR1	ACVR1	ACVR1	11439	-0.016	0.19	NO
64	CUL1	CUL1	CUL1	11546	-0.018	0.19	NO
65	PPP2CA	PPP2CA	PPP2CA	11807	-0.023	0.18	NO
66	RPS6KB2	RPS6KB2	RPS6KB2	12071	-0.027	0.16	NO
67	MAPK1	MAPK1	MAPK1	12177	-0.029	0.16	NO
68	SMAD3	SMAD3	SMAD3	12248	-0.03	0.16	NO
69	TFDP1	TFDP1	TFDP1	12416	-0.034	0.15	NO
70	MAPK3	MAPK3	MAPK3	12476	-0.035	0.15	NO
71	RBX1	RBX1	RBX1	12669	-0.038	0.14	NO
72	ACVR1C	ACVR1C	ACVR1C	13041	-0.046	0.13	NO
73	THBS1	THBS1	THBS1	13316	-0.052	0.12	NO
74	ACVRL1	ACVRL1	ACVRL1	13650	-0.06	0.1	NO
75	RBL1	RBL1	RBL1	13745	-0.062	0.1	NO
76	RHOA	RHOA	RHOA	13768	-0.063	0.11	NO
77	ROCK1	ROCK1	ROCK1	14953	-0.1	0.052	NO
78	TGFBR2	TGFBR2	TGFBR2	15022	-0.1	0.058	NO
79	LTBP1	LTBP1	LTBP1	15194	-0.11	0.058	NO
80	TGFB1	TGFB1	TGFB1	15532	-0.13	0.05	NO
81	THBS2	THBS2	THBS2	16156	-0.16	0.03	NO
82	TNF	TNF	TNF	17223	-0.27	-0.0059	NO
83	CDKN2B	CDKN2B	CDKN2B	17388	-0.3	0.011	NO
84	IFNG	IFNG	IFNG	17787	-0.37	0.021	NO