Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	95.0	4399.0	46.0	-0.635	0.012	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by the Hedgehog family	88.0	4617.0	52.0	-0.242	0.174	1000.0	-1000.0	-0.068	-1000.0
TCGA08_retinoblastoma	76.0	614.0	8.0	-0.156	0.066	1000.0	-1000.0	-0.017	-1000.0
IL4-mediated signaling events	69.0	6337.0	91.0	-0.794	0.614	1000.0	-1000.0	-0.174	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	67.0	2291.0	34.0	-0.127	0.01	1000.0	-1000.0	-0.05	-1000.0
Ephrin A  reverse signaling	67.0	470.0	7.0	-0.087	-0.0	1000.0	-1000.0	-0.022	-1000.0
TCGA08_p53	66.0	462.0	7.0	-0.114	0.063	1000.0	-1000.0	-0.012	-1000.0
Wnt signaling	59.0	414.0	7.0	-0.125	-0.019	1000.0	-1000.0	-0.031	-1000.0
p75(NTR)-mediated signaling	50.0	6254.0	125.0	-0.21	0.014	1000.0	-1000.0	-0.087	-1000.0
Glypican 1 network	49.0	2380.0	48.0	-0.238	0.038	1000.0	-1000.0	-0.044	-1000.0
IL23-mediated signaling events	49.0	2979.0	60.0	-0.412	0.01	1000.0	-1000.0	-0.185	-1000.0
EGFR-dependent Endothelin signaling events	46.0	970.0	21.0	-0.142	0.015	1000.0	-1000.0	-0.051	-1000.0
Signaling events regulated by Ret tyrosine kinase	45.0	3741.0	82.0	-0.142	0.01	1000.0	-1000.0	-0.078	-1000.0
HIF-1-alpha transcription factor network	39.0	2993.0	76.0	-0.341	0.016	1000.0	-1000.0	-0.174	-1000.0
Glucocorticoid receptor regulatory network	38.0	4367.0	114.0	-0.531	0.271	1000.0	-1000.0	-0.06	-1000.0
Visual signal transduction: Cones	37.0	1421.0	38.0	-0.149	0.009	1000.0	-1000.0	-0.054	-1000.0
BMP receptor signaling	37.0	3038.0	81.0	-0.248	0.027	1000.0	-1000.0	-0.081	-1000.0
Effects of Botulinum toxin	37.0	983.0	26.0	-0.14	0.01	1000.0	-1000.0	-0.048	-1000.0
Syndecan-1-mediated signaling events	36.0	1249.0	34.0	-0.163	0.01	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Rods	35.0	1843.0	52.0	-0.163	0.01	1000.0	-1000.0	-0.063	-1000.0
Fc-epsilon receptor I signaling in mast cells	34.0	3363.0	97.0	-0.164	0.023	1000.0	-1000.0	-0.085	-1000.0
Reelin signaling pathway	34.0	1925.0	56.0	-0.151	0.014	1000.0	-1000.0	-0.067	-1000.0
BCR signaling pathway	34.0	3450.0	99.0	-0.149	0.014	1000.0	-1000.0	-0.078	-1000.0
TCR signaling in naïve CD8+ T cells	33.0	3160.0	93.0	-0.154	0.085	1000.0	-1000.0	-0.076	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2298.0	68.0	-0.214	0.057	1000.0	-1000.0	-0.109	-1000.0
Noncanonical Wnt signaling pathway	32.0	854.0	26.0	-0.125	0.01	1000.0	-1000.0	-0.054	-1000.0
Endothelins	31.0	3032.0	96.0	-0.194	0.026	1000.0	-1000.0	-0.078	-1000.0
amb2 Integrin signaling	30.0	2515.0	82.0	-0.185	0.01	1000.0	-1000.0	-0.069	-1000.0
Signaling mediated by p38-alpha and p38-beta	30.0	1321.0	44.0	-0.099	0.01	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	29.0	2527.0	87.0	-0.188	0.03	1000.0	-1000.0	-0.127	-1000.0
ErbB4 signaling events	28.0	1936.0	69.0	-0.192	0.051	1000.0	-1000.0	-0.076	-1000.0
Syndecan-4-mediated signaling events	27.0	1856.0	67.0	-0.111	0.011	1000.0	-1000.0	-0.075	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	26.0	1449.0	54.0	-0.113	0.015	1000.0	-1000.0	-0.078	-1000.0
Arf6 signaling events	26.0	1621.0	62.0	-0.142	0.01	1000.0	-1000.0	-0.056	-1000.0
EPHB forward signaling	26.0	2224.0	85.0	-0.085	0.068	1000.0	-1000.0	-0.084	-1000.0
Calcium signaling in the CD4+ TCR pathway	26.0	819.0	31.0	-0.129	0.011	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	26.0	3140.0	120.0	-0.257	0.12	1000.0	-1000.0	-0.065	-1000.0
Osteopontin-mediated events	25.0	976.0	38.0	-0.107	0.01	1000.0	-1000.0	-0.087	-1000.0
Thromboxane A2 receptor signaling	25.0	2669.0	105.0	-0.142	0.019	1000.0	-1000.0	-0.056	-1000.0
Ephrin B reverse signaling	25.0	1237.0	48.0	-0.083	0.06	1000.0	-1000.0	-0.066	-1000.0
Retinoic acid receptors-mediated signaling	25.0	1489.0	58.0	-0.17	0.01	1000.0	-1000.0	-0.064	-1000.0
Nectin adhesion pathway	24.0	1516.0	63.0	-0.073	0.013	1000.0	-1000.0	-0.071	-1000.0
Canonical Wnt signaling pathway	22.0	1151.0	51.0	-0.221	0.031	1000.0	-1000.0	-0.054	-1000.0
LPA receptor mediated events	22.0	2248.0	102.0	-0.131	0.027	1000.0	-1000.0	-0.077	-1000.0
IGF1 pathway	22.0	1260.0	57.0	-0.09	0.023	1000.0	-1000.0	-0.097	-1000.0
ErbB2/ErbB3 signaling events	21.0	1378.0	65.0	-0.132	0.019	1000.0	-1000.0	-0.058	-1000.0
S1P5 pathway	21.0	360.0	17.0	-0.072	0.048	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	20.0	250.0	12.0	-0.049	0.014	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	20.0	1049.0	52.0	-0.122	0.015	1000.0	-1000.0	-0.055	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	20.0	1540.0	74.0	-0.173	0.039	1000.0	-1000.0	-0.074	-1000.0
Presenilin action in Notch and Wnt signaling	19.0	1218.0	61.0	-0.221	0.021	1000.0	-1000.0	-0.065	-1000.0
Glypican 2 network	19.0	79.0	4.0	-0.032	-0.019	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	19.0	1532.0	78.0	-0.06	0.022	1000.0	-1000.0	-0.076	-1000.0
Syndecan-2-mediated signaling events	18.0	1256.0	69.0	-0.111	0.029	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PTP1B	18.0	1370.0	76.0	-0.143	0.015	1000.0	-1000.0	-0.073	-1000.0
IL27-mediated signaling events	18.0	968.0	51.0	-0.185	0.02	1000.0	-1000.0	-0.078	-1000.0
IL1-mediated signaling events	17.0	1073.0	62.0	-0.122	0.049	1000.0	-1000.0	-0.08	-1000.0
Syndecan-3-mediated signaling events	17.0	601.0	35.0	-0.094	0.01	1000.0	-1000.0	-0.055	-1000.0
Class IB PI3K non-lipid kinase events	17.0	51.0	3.0	-0.014	-1000.0	1000.0	-1000.0	-0.007	-1000.0
FOXM1 transcription factor network	17.0	897.0	51.0	-0.163	0.101	1000.0	-1000.0	-0.186	-1000.0
Caspase cascade in apoptosis	15.0	1130.0	74.0	-0.062	0.016	1000.0	-1000.0	-0.037	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	445.0	28.0	-0.072	0.022	1000.0	-1000.0	-0.032	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	995.0	65.0	-0.302	0.04	1000.0	-1000.0	-0.053	-1000.0
S1P1 pathway	15.0	565.0	36.0	-0.07	0.01	1000.0	-1000.0	-0.052	-1000.0
Nongenotropic Androgen signaling	15.0	782.0	52.0	-0.05	0.017	1000.0	-1000.0	-0.049	-1000.0
S1P4 pathway	15.0	376.0	25.0	-0.072	0.016	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling events	15.0	78.0	5.0	-0.029	0.01	1000.0	-1000.0	-0.044	-1000.0
FAS signaling pathway (CD95)	14.0	670.0	47.0	-0.102	0.012	1000.0	-1000.0	-0.04	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1270.0	86.0	-0.088	0.017	1000.0	-1000.0	-0.075	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	252.0	17.0	-0.036	0.01	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	13.0	990.0	76.0	-0.216	0.021	1000.0	-1000.0	-0.043	-1000.0
JNK signaling in the CD4+ TCR pathway	13.0	226.0	17.0	-0.036	0.018	1000.0	-1000.0	-0.052	-1000.0
Integrins in angiogenesis	13.0	1107.0	84.0	-0.11	0.017	1000.0	-1000.0	-0.08	-1000.0
Angiopoietin receptor Tie2-mediated signaling	13.0	1222.0	88.0	-0.123	0.047	1000.0	-1000.0	-0.1	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	13.0	451.0	33.0	-0.158	0.029	1000.0	-1000.0	-0.046	-1000.0
Cellular roles of Anthrax toxin	12.0	473.0	39.0	-0.036	0.012	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	12.0	877.0	70.0	-0.229	0.02	1000.0	-1000.0	-0.06	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	431.0	37.0	-0.111	0.023	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by PI3K	11.0	687.0	58.0	-0.105	0.024	1000.0	-1000.0	-0.081	-1000.0
Regulation of p38-alpha and p38-beta	11.0	611.0	54.0	-0.132	0.01	1000.0	-1000.0	-0.057	-1000.0
Class I PI3K signaling events	11.0	869.0	73.0	-0.132	0.017	1000.0	-1000.0	-0.055	-1000.0
Regulation of Telomerase	11.0	1221.0	102.0	-0.143	0.034	1000.0	-1000.0	-0.088	-1000.0
S1P3 pathway	11.0	492.0	42.0	-0.049	0.015	1000.0	-1000.0	-0.033	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1466.0	136.0	-0.139	0.049	1000.0	-1000.0	-0.063	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	864.0	85.0	-0.04	0.028	1000.0	-1000.0	-0.073	-1000.0
IL6-mediated signaling events	10.0	781.0	75.0	-0.07	0.044	1000.0	-1000.0	-0.092	-1000.0
Signaling events mediated by PRL	10.0	353.0	34.0	-0.147	0.023	1000.0	-1000.0	-0.041	-1000.0
IFN-gamma pathway	9.0	622.0	68.0	-0.078	0.029	1000.0	-1000.0	-0.092	-1000.0
IL2 signaling events mediated by STAT5	9.0	208.0	22.0	-0.048	0.021	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in keratinocytes	9.0	428.0	43.0	-0.036	0.02	1000.0	-1000.0	-0.062	-1000.0
Aurora B signaling	9.0	654.0	67.0	-0.148	0.01	1000.0	-1000.0	-0.068	-1000.0
PLK2 and PLK4 events	8.0	24.0	3.0	-0.003	0.006	1000.0	-1000.0	-0.014	-1000.0
Ceramide signaling pathway	8.0	681.0	76.0	-0.142	0.035	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class III	8.0	349.0	40.0	-0.105	0.017	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	129.0	15.0	-0.015	0.02	1000.0	-1000.0	-0.023	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	8.0	400.0	45.0	-0.047	0.033	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	663.0	76.0	-0.037	0.032	1000.0	-1000.0	-0.08	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	658.0	83.0	-0.173	0.045	1000.0	-1000.0	-0.061	-1000.0
TCGA08_rtk_signaling	7.0	190.0	26.0	-0.036	0.031	1000.0	-1000.0	-0.021	-1000.0
Insulin Pathway	7.0	580.0	74.0	-0.087	0.027	1000.0	-1000.0	-0.077	-1000.0
PDGFR-beta signaling pathway	7.0	728.0	97.0	-0.102	0.041	1000.0	-1000.0	-0.071	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	33.0	5.0	-0.002	0.006	1000.0	-1000.0	-0.021	-1000.0
Aurora A signaling	6.0	375.0	60.0	-0.061	0.025	1000.0	-1000.0	-0.048	-1000.0
Arf6 downstream pathway	6.0	273.0	43.0	-0.036	0.017	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	6.0	427.0	68.0	-0.073	0.025	1000.0	-1000.0	-0.05	-1000.0
TRAIL signaling pathway	6.0	312.0	48.0	-0.028	0.031	1000.0	-1000.0	-0.059	-1000.0
Rapid glucocorticoid signaling	6.0	136.0	20.0	-0.021	0.01	1000.0	-1000.0	-0.031	-1000.0
EPO signaling pathway	5.0	314.0	55.0	-0.041	0.029	1000.0	-1000.0	-0.089	-1000.0
PLK1 signaling events	5.0	502.0	85.0	-0.022	0.02	1000.0	-1000.0	-0.038	-1000.0
PDGFR-alpha signaling pathway	5.0	258.0	44.0	-0.042	0.026	1000.0	-1000.0	-0.041	-1000.0
p38 MAPK signaling pathway	5.0	260.0	44.0	-0.078	0.016	1000.0	-1000.0	-0.067	-1000.0
BARD1 signaling events	4.0	247.0	57.0	-0.022	0.041	1000.0	-1000.0	-0.051	-1000.0
Circadian rhythm pathway	4.0	108.0	22.0	-0.012	0.026	1000.0	-1000.0	-0.05	-1000.0
Aurora C signaling	4.0	33.0	7.0	-0.014	0.0	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	4.0	260.0	64.0	-0.073	0.099	1000.0	-1000.0	-0.071	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	179.0	36.0	-0.011	0.02	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	580.0	125.0	-0.016	0.054	1000.0	-1000.0	-0.075	-1000.0
Arf6 trafficking events	4.0	301.0	71.0	-0.051	0.032	1000.0	-1000.0	-0.056	-1000.0
Canonical NF-kappaB pathway	3.0	121.0	39.0	-0.028	0.052	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class II	3.0	256.0	75.0	-0.022	0.023	1000.0	-1000.0	-0.05	-1000.0
Insulin-mediated glucose transport	3.0	120.0	32.0	-0.073	0.024	1000.0	-1000.0	-0.056	-1000.0
HIF-2-alpha transcription factor network	3.0	162.0	43.0	-0.072	0.073	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class I	3.0	330.0	104.0	-0.052	0.042	1000.0	-1000.0	-0.06	-1000.0
Atypical NF-kappaB pathway	3.0	95.0	31.0	-0.021	0.028	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	3.0	209.0	56.0	-0.012	0.033	1000.0	-1000.0	-0.063	-1000.0
ceramide signaling pathway	2.0	133.0	49.0	-0.032	0.027	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	1.0	90.0	53.0	-0.025	0.016	1000.0	-1000.0	-0.059	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	14.0	23.0	-0.002	0.033	1000.0	-1000.0	-0.05	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	19.0	27.0	-0.005	0.025	1000.0	-1000.0	-0.047	-1000.0
Arf1 pathway	0.0	36.0	54.0	-0.009	0.021	1000.0	-1000.0	-0.043	-1000.0
Alternative NF-kappaB pathway	0.0	8.0	13.0	-0.001	0.014	1000.0	-1000.0	-0.062	-1000.0
Total	2623	147669	7203	-15.3933265103	-995.645790901	131000	-131000	-8.1946568279	-131000