rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BCL2L1(1), IL3RA(1), KIT(27), PIK3CA(3), PIK3R1(1), PRKAR2B(2)	5007558	35	32	20	5	0	10	9	15	1	0	0.111	1.14e-06	0.000701
2	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(1), ARPC2(1), PAK1(1), PDGFRA(1), PIK3CA(3), PIK3R1(1), RAC1(4), WASL(2)	3047557	14	14	12	0	2	7	2	3	0	0	0.0252	0.000147	0.0453
3	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(1), KLRC3(2), KLRC4(1), PAK1(1), PIK3CA(3), PIK3R1(1), PTK2B(1), RAC1(4), SYK(1), VAV1(2)	4322569	17	16	15	0	3	7	3	4	0	0	0.00883	0.000699	0.143
4	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1B(1), ARPC2(1), RAC1(4), WASL(2)	1876385	9	9	8	0	1	4	2	2	0	0	0.0893	0.00286	0.440
5	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	BCL2L1(1), HRAS(1), PIK3CA(3), PIK3R1(1), RAC1(4), RAF1(1), RALGDS(1), RELA(1), RHOA(1)	4462015	14	14	12	1	2	5	2	3	2	0	0.0747	0.00386	0.476
6	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT3(1), BLNK(1), BTK(1), CARD11(1), CD19(1), CD79A(1), CD79B(1), FOS(2), HRAS(1), INPP5D(1), KRAS(19), MALT1(1), NFATC2(4), NFATC4(1), NFKB2(2), NFKBIB(1), NRAS(7), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP3R2(1), RAC1(4), SYK(1), VAV1(2), VAV3(1)	17419085	66	52	48	9	8	32	12	13	1	0	0.00346	0.00538	0.553
7	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(3), DHFR(1), POLB(1), POLD1(2), POLG(2)	2969192	11	11	11	1	5	5	1	0	0	0	0.0904	0.0187	1.000
8	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT3(1), BTK(1), HRAS(1), INPP5D(1), KRAS(19), LCP2(1), MAP2K2(1), MAPK10(1), MAPK11(1), NRAS(7), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PLA2G6(1), RAC1(4), RAF1(1), SOS1(3), SYK(1), VAV1(2), VAV3(1)	16388160	58	48	40	8	7	24	12	14	1	0	0.0107	0.0198	1.000
9	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(6), DFFB(1), SET(1)	2382845	9	9	9	0	0	7	1	0	1	0	0.0816	0.0203	1.000
10	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), FOS(2), HRAS(1), KLK2(1), NGFR(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3)	4359991	14	13	13	1	2	7	2	2	1	0	0.0884	0.0285	1.000
11	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(1), MAPK7(3), MEF2A(3), MEF2B(1), MEF2C(1), NTRK1(1), PIK3CA(3), PIK3R1(1), RPS6KA1(2)	4532448	16	16	12	2	4	10	0	1	1	0	0.0764	0.0319	1.000
12	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT3(1), ILK(1), PIK3CA(3), PIK3CD(4), PTK2B(1), RBL2(1), SOS1(3)	4601358	14	12	12	1	2	6	3	2	1	0	0.105	0.0374	1.000
13	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNAR2(1), JAK1(1), STAT1(2), TYK2(3)	2481181	8	8	8	0	1	5	1	0	1	0	0.0980	0.0376	1.000
14	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1B(1), ADH4(1), AKR1C4(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), BAAT(2), CEL(3), CYP7A1(2), SOAT2(1)	5259287	15	14	15	1	4	10	0	1	0	0	0.0350	0.0390	1.000
15	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3)	495479	3	3	3	0	1	1	1	0	0	0	0.361	0.0408	1.000
16	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CD97(4), CRHR1(1), EMR1(3), GPR64(1), LPHN1(3), LPHN2(2), LPHN3(1), VIPR1(1)	6416433	16	16	16	1	3	7	2	3	1	0	0.0325	0.0415	1.000
17	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(2), CDC25C(1), CSK(2), PTPRA(1)	2086957	7	7	7	0	2	3	1	0	1	0	0.0950	0.0469	1.000
18	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT3(1), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(3), PIK3CD(4), SOS1(3)	3823993	15	13	13	2	2	6	3	2	2	0	0.164	0.0498	1.000
19	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT7(2), CHST1(1), CHST2(3), CHST4(2), FUT8(1), ST3GAL2(1), ST3GAL4(1)	2782968	12	12	12	3	1	5	4	1	1	0	0.402	0.0521	1.000
20	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BLNK(1), FOS(2), HRAS(1), MAPK8IP3(4), RAC1(4), RPS6KA1(2), SOS1(3), SYK(1), VAV1(2), VAV3(1)	7374227	22	20	21	3	3	11	4	3	1	0	0.101	0.0553	1.000
21	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), GAD1(1), GAD2(1), GGT1(1)	1338011	5	5	5	0	0	3	1	1	0	0	0.238	0.0566	1.000
22	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), GAD2(1), HMGCL(1), L2HGDH(1), PDHA1(1), PDHA2(1), SDHB(1)	5845779	15	14	15	1	4	8	1	0	2	0	0.0378	0.0578	1.000
23	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(6), EP300(2), IL7R(1), JAK1(1), PIK3CA(3), PIK3R1(1), PTK2B(1)	6389780	15	15	14	1	1	9	0	2	3	0	0.0869	0.0609	1.000
24	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), CDC25B(2), CDC25C(1), CDK7(1), XPO1(1)	1951393	6	6	6	0	1	2	1	1	1	0	0.196	0.0618	1.000
25	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(2), LTB4R(2), P2RY1(1)	1288591	5	5	4	1	1	2	2	0	0	0	0.435	0.0683	1.000
26	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), GNA12(1), PRKAR2B(2)	2295394	7	7	7	0	1	3	0	1	2	0	0.131	0.0712	1.000
27	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), HRAS(1), JAK2(2), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1)	6825758	17	16	16	1	3	9	1	3	1	0	0.0465	0.0721	1.000
28	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCNE1(1), HRAS(1), PAK1(1), PIK3CA(3), PIK3R1(1), RAC1(4), RAF1(1), RELA(1), TFDP1(1)	4628956	14	14	12	2	2	7	1	4	0	0	0.208	0.0724	1.000
29	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(2), PELP1(2)	3435339	10	10	10	1	0	8	0	0	2	0	0.217	0.0826	1.000
30	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(2), CDK7(1), NEK1(1)	1721464	5	5	5	0	1	2	1	0	1	0	0.252	0.0861	1.000
31	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS2(1), ILVBL(3), PDHA1(1), PDHA2(1), VARS2(4)	4238584	10	10	10	1	2	3	4	0	1	0	0.161	0.0903	1.000
32	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(1), GNS(1), HEXA(1), IDUA(2), LCT(2), NAGLU(1)	3357024	9	9	9	0	1	5	3	0	0	0	0.0591	0.0914	1.000
33	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP17A1(2), HSD3B1(1)	1559671	5	5	5	0	1	2	0	0	2	0	0.163	0.0975	1.000
34	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), ILK(1), PDK2(1), PDPK1(1), PIK3CA(3), PIK3R1(1), PTK2(1), SOS1(3)	4535625	12	11	11	1	2	6	1	2	1	0	0.163	0.0993	1.000
35	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT3(1), CARD11(1), CBL(1), CBLC(1), FOS(2), HRAS(1), KRAS(19), LCP2(1), MALT1(1), MAP3K14(1), NFATC2(4), NFATC4(1), NFKB2(2), NFKBIB(1), NRAS(7), PAK1(1), PAK3(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP3R2(1), RASGRP1(1), RHOA(1), SOS1(3), VAV1(2), VAV3(1)	23565567	66	48	49	7	5	33	12	11	5	0	0.000976	0.100	1.000
36	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CD79A(1), CD79B(1), FOS(2), HRAS(1), NFATC2(4), NFATC4(1), RAC1(4), RAF1(1), SOS1(3), SYK(1), VAV1(2)	8700425	23	21	22	3	6	9	4	3	1	0	0.0692	0.102	1.000
37	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(2), STAT1(2)	1842401	5	5	5	0	1	3	0	0	1	0	0.288	0.104	1.000
38	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(3)	1147443	4	4	4	1	1	3	0	0	0	0	0.592	0.106	1.000
39	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD9(1), ADH1B(1), ADH4(1), AKR1C4(1), ALDH1B1(1), ALDH3A1(2), BAAT(2), CEL(3), CYP7A1(2), RDH13(2), SOAT2(1)	7232939	17	16	17	1	4	11	0	2	0	0	0.0213	0.106	1.000
40	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5R1(1), MYL2(1), PAK1(1), PDGFRA(1), PIK3CA(3), PIK3R1(1), RAC1(4), TRIO(3), VAV1(2)	7989301	17	17	15	0	6	6	1	3	1	0	0.00539	0.109	1.000
41	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(1), KLK2(1), NTRK1(1), PIK3CA(3), PIK3R1(1), SOS1(3)	3540455	10	9	9	1	0	4	2	2	2	0	0.264	0.113	1.000
42	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	FOS(2), HRAS(1), JAK2(2), MYC(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3), STAT1(2)	6323941	16	15	15	2	2	9	1	3	1	0	0.154	0.119	1.000
43	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(1), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ECHS1(1), EHHADH(1), MLYCD(1), PCCA(3), SUCLG2(2)	7472009	15	14	15	1	2	6	4	1	2	0	0.0511	0.120	1.000
44	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(2), TYK2(3)	2379915	6	6	6	1	2	3	0	0	1	0	0.448	0.121	1.000
45	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(2), TYK2(3)	2379915	6	6	6	1	2	3	0	0	1	0	0.448	0.121	1.000
46	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(1), NOTCH1(5)	2287100	7	7	7	1	1	2	1	0	3	0	0.250	0.122	1.000
47	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), STAT3(1), TYK2(3)	2771906	7	7	7	1	2	3	0	1	1	0	0.366	0.125	1.000
48	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH4(1), AKR1B1(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), CEL(3), DGKD(2), DGKG(1), DGKQ(3), DGKZ(4), GLA(1), LCT(2), LIPC(2)	11182404	25	23	25	2	9	12	1	1	2	0	0.00653	0.131	1.000
49	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), GNAS(1), HRAS(1), KLK2(1), MAP2K2(1), MKNK2(2), MYC(1), NGFR(1), PDGFRA(1), RAF1(1), RPS6KA1(2), RPS6KA5(1), SOS1(3), STAT3(1)	7711528	18	16	18	2	4	4	2	5	3	0	0.118	0.135	1.000
50	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1), ECHS1(1)	1233807	3	3	3	1	0	1	0	1	1	0	0.708	0.141	1.000
51	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(1), TH(1), TPH1(2)	1383157	5	4	5	0	1	2	1	1	0	0	0.219	0.144	1.000
52	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(2), RELA(1), XDH(2)	2315548	6	6	6	1	2	4	0	0	0	0	0.359	0.147	1.000
53	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), HRAS(1), KLK2(1), MAP2K2(1), NGFR(1), RAF1(1)	1922173	8	6	8	1	2	5	1	0	0	0	0.175	0.148	1.000
54	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), FOS(2), HRAS(1), JAK1(1), PDGFRA(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1)	7977188	17	16	16	1	3	8	1	3	2	0	0.0561	0.151	1.000
55	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), FOS(2), HRAS(1), IRS1(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3)	5625698	13	12	12	1	3	6	1	2	1	0	0.103	0.155	1.000
56	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	MAPK10(1), MAPK11(1), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), NFKB2(2), NFKBIB(1), NFKBIL1(2), PIK3CA(3), PIK3CD(4), PIK3R1(1), TRAF2(1), TRAF3(1)	8303700	25	24	23	4	4	15	4	1	1	0	0.0557	0.156	1.000
57	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(1), SP1(1), TP53(2)	1618134	4	4	4	0	1	1	1	1	0	0	0.313	0.158	1.000
58	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP2(2), FUK(2), GMPPA(1), GMPPB(1), HK2(3), HK3(3), MTMR6(1), PFKFB2(1), PFKFB3(2), RDH13(2)	8615580	20	19	20	2	9	9	1	1	0	0	0.0198	0.160	1.000
59	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1B(1), ARPC2(1), NTRK1(1), RAC1(4), WASF2(2), WASL(2)	3489082	12	10	11	2	1	5	2	2	2	0	0.338	0.160	1.000
60	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(3), MST1R(2)	1454065	6	6	4	2	3	2	0	0	1	0	0.564	0.170	1.000
61	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ECHS1(1), EHHADH(1)	2752623	6	6	6	0	2	2	1	0	1	0	0.109	0.178	1.000
62	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(3), HK3(3)	2384716	6	6	6	0	5	1	0	0	0	0	0.102	0.182	1.000
63	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(1), STAT1(2), TYK2(3)	2853570	7	7	7	0	1	5	0	0	1	0	0.110	0.185	1.000
64	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(1), HEXA(1), HK2(3), HK3(3), UAP1(1)	3935430	9	9	9	0	5	4	0	0	0	0	0.0404	0.188	1.000
65	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CRK(1), GNAQ(1), HRAS(1), PIK3C2G(2), PIK3CA(3), PIK3R1(1), PTK2(1), PTK2B(1), PXN(2), RAF1(1), RELA(1)	6476156	16	15	15	2	2	11	1	2	0	0	0.101	0.201	1.000
66	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS1(1)	704430	2	2	2	1	0	1	0	1	0	0	0.830	0.206	1.000
67	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), DOCK1(1), FOS(2), GAB1(1), HRAS(1), MAP2K2(1), PAK1(1), PIK3CA(3), PIK3R1(1), PTK2(1), PTK2B(1), PXN(2), RAF1(1), RAP1B(1), SOS1(3), STAT3(1)	10367121	23	22	22	2	3	13	2	3	2	0	0.0353	0.216	1.000
68	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), SKP2(1), TFDP1(1), UBE2M(2)	1957102	5	5	5	1	0	4	0	1	0	0	0.547	0.217	1.000
69	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP17A1(2), CYP21A2(1), HSD3B1(1)	2063308	5	5	5	1	0	3	0	0	2	0	0.429	0.219	1.000
70	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP17A1(2), CYP21A2(1), HSD3B1(1)	2063308	5	5	5	1	0	3	0	0	2	0	0.429	0.219	1.000
71	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(1), GNS(1), HEXA(1), HYAL2(1), IDUA(2), LCT(2), NAGLU(1)	4809418	10	10	10	1	2	5	3	0	0	0	0.149	0.220	1.000
72	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TYR(1)	1046969	3	3	3	0	0	3	0	0	0	0	0.376	0.221	1.000
73	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(3)	1824866	4	4	4	1	0	3	0	0	1	0	0.825	0.226	1.000
74	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(1), PON1(1), RDH13(2)	1992371	4	4	4	0	1	0	1	1	1	0	0.306	0.229	1.000
75	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(6), EP300(2), FADD(1), RELA(1), TNFRSF1A(1)	5243381	11	11	11	0	0	8	1	0	2	0	0.0487	0.229	1.000
76	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), PDE6D(1)	870890	2	2	2	1	1	0	1	0	0	0	0.827	0.230	1.000
77	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(1), ACACB(1), ACADM(1), ALDH1B1(1), ALDH3A1(2), ECHS1(1), EHHADH(1), HIBCH(1), LDHAL6A(1), MLYCD(1), PCCA(3), SUCLG2(2)	8972731	16	15	16	1	1	7	4	1	3	0	0.0409	0.231	1.000
78	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), FUT8(1), ST3GAL2(1), ST3GAL4(1)	1749010	4	4	4	1	0	2	1	1	0	0	0.619	0.233	1.000
79	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP2(2), GMPPA(1), GMPPB(1), HK2(3), HK3(3), PFKFB3(2)	5544072	14	14	14	2	7	6	1	0	0	0	0.0848	0.234	1.000
80	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB5(1), NDUFB6(1), NDUFS1(1), NDUFV1(1)	1600284	4	4	4	0	1	3	0	0	0	0	0.292	0.238	1.000
81	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(2), THBS1(1)	1620871	4	4	4	1	0	3	1	0	0	0	0.596	0.239	1.000
82	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	HRAS(1), IRS1(1), JAK2(2), PIK3CA(3), PIK3R1(1), RAF1(1), RPS6KA1(2), SOCS1(1), SOS1(3)	7556300	15	14	14	1	5	6	1	2	1	0	0.0542	0.244	1.000
83	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(6), HRAS(1), PML(2), RARA(1), SP100(1), TNFRSF1A(1), TP53(2)	4284152	14	13	14	3	1	8	3	0	2	0	0.362	0.246	1.000
84	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIT1(1), CYB5R3(1), HEXA(1), HK2(3), HK3(3), MTMR6(1), NANS(1), NPL(1), UAP1(1)	6590768	14	14	14	0	5	9	0	0	0	0	0.00808	0.248	1.000
85	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(2), PPARG(1)	4100914	9	9	9	1	0	6	0	0	3	0	0.391	0.249	1.000
86	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GGT1(1)	1313137	3	3	3	0	1	1	1	0	0	0	0.366	0.252	1.000
87	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(1), PC(2), PDHA1(1)	2110479	5	5	5	1	1	3	0	1	0	0	0.451	0.252	1.000
88	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2)	1800966	4	4	4	0	2	2	0	0	0	0	0.215	0.258	1.000
89	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2)	1800966	4	4	4	0	2	2	0	0	0	0	0.215	0.258	1.000
90	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(1)	661618	2	2	2	0	0	2	0	0	0	0	0.470	0.258	1.000
91	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1B(1), ADH4(1), AKR1C4(1), ALDH3A1(2), ALDH3B2(1), CYP1A1(2), CYP2C19(1), DHDH(3), EPHX1(1), GSTA4(1), GSTK1(1), UGT1A10(1), UGT1A4(1), UGT2A3(1), UGT2B10(1), UGT2B11(1), UGT2B7(1)	13029030	21	20	21	1	3	11	1	5	1	0	0.0120	0.260	1.000
92	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), HSD17B4(1), HSD3B1(1)	1813135	4	4	4	1	0	2	0	0	2	0	0.654	0.263	1.000
93	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY2(2), NPAS2(2), PER2(2), PER3(1)	3948886	9	9	9	1	2	5	1	1	0	0	0.194	0.271	1.000
94	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH13(2)	1040853	2	2	2	0	1	0	0	1	0	0	0.552	0.272	1.000
95	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), FOS(2), HRAS(1), IRS1(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3)	5802443	13	12	12	2	3	6	1	2	1	0	0.229	0.273	1.000
96	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), ENPP3(1), NADSYN1(1), NMNAT2(1), NNMT(1), NNT(1), QPRT(1)	3345153	7	7	7	1	0	6	0	0	1	0	0.421	0.274	1.000
97	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), ITGAX(3), TLR2(1), TLR7(2), TLR9(1)	4214296	8	8	8	1	2	4	0	1	1	0	0.254	0.279	1.000
98	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FOS(2), HRAS(1), NFATC2(4), NFATC4(1), PIK3CA(3), PIK3R1(1), RAC1(4), RAF1(1), RELA(1), SOS1(3), VAV1(2)	10960931	23	22	21	3	4	11	3	4	1	0	0.0850	0.283	1.000
99	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(1)	1102045	2	2	2	0	0	0	1	0	1	0	0.493	0.284	1.000
100	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CSF1(1), FCGR3A(1), SELL(1), TGFB1(1), TNFRSF1A(1)	3205170	7	7	7	1	1	4	1	1	0	0	0.316	0.285	1.000
101	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CREBBP(6), EP300(2), MAP3K7(1), TGFB1(1)	5786247	11	11	11	1	1	7	1	0	2	0	0.204	0.286	1.000
102	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOA1(1), APOA4(1), CYP7A1(2), HMGCR(2), LDLR(1), LIPC(2), LRP1(2), SCARB1(2)	6201903	14	13	14	1	2	10	0	0	2	0	0.0332	0.286	1.000
103	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR39(2), GPR45(2), GPR68(1)	2226799	6	6	6	2	1	3	0	1	1	0	0.618	0.288	1.000
104	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(6), EP300(2), MAP3K14(1), MAP3K7(1), MAPK11(1), NR3C1(1), RELA(1), TLR2(1)	6722422	14	13	14	1	2	10	0	0	2	0	0.0759	0.289	1.000
105	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	HRAS(1), IRS1(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3)	4238075	10	9	9	2	2	4	1	2	1	0	0.432	0.289	1.000
106	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(1), GABRA4(1), GPX1(1)	1487811	3	3	3	0	2	0	1	0	0	0	0.323	0.294	1.000
107	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(3), HK3(3)	2721344	6	6	6	1	5	1	0	0	0	0	0.270	0.299	1.000
108	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(1), ALDH1B1(1), ALDH3A1(2), AOC3(1), ECHS1(1), EHHADH(1), GAD1(1), GAD2(1), HIBCH(1), MLYCD(1), SMS(1)	6040313	12	12	12	2	1	5	3	2	1	0	0.243	0.301	1.000
109	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(1)	997865	2	2	2	0	0	0	1	0	1	0	0.551	0.301	1.000
110	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	DBH(1), DDC(2), GAD1(1), GAD2(1), MAOA(2), TH(1), TPH1(2)	3360610	10	7	10	0	1	6	1	1	1	0	0.0343	0.303	1.000
111	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2)	721861	2	2	2	1	1	1	0	0	0	0	0.761	0.305	1.000
112	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), NFATC2(4), PRKAR2B(2)	2889841	7	6	7	1	1	4	2	0	0	0	0.295	0.307	1.000
113	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	FOS(2), HRAS(1), IL3RA(1), JAK2(2), RAF1(1), SOS1(3)	4095551	10	9	10	2	2	4	1	2	1	0	0.407	0.308	1.000
114	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), PTK2B(1), SOS1(3)	1970426	5	4	5	0	1	1	1	1	1	0	0.325	0.311	1.000
115	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFB(1), HMGB1(1), TOP2A(1)	2413183	4	4	4	0	1	1	1	1	0	0	0.365	0.314	1.000
116	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGFR(1), FOS(2), HRAS(1), JAK1(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1)	8546820	17	16	16	2	2	9	1	3	2	0	0.152	0.314	1.000
117	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(1), ACADM(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), AOC3(1), ECHS1(1), EHHADH(1), GAD1(1), GAD2(1), MLYCD(1), SMS(1)	6497994	13	13	13	2	2	5	3	2	1	0	0.188	0.322	1.000
118	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	381750	1	1	1	0	1	0	0	0	0	0	0.726	0.323	1.000
119	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), HMGN1(1), HRAS(1), MAP3K7(1), MAP3K9(1), MEF2A(3), MEF2B(1), MEF2C(1), MYC(1), RAC1(4), RPS6KA5(1), STAT1(2), TGFB1(1), TRAF2(1)	8561842	20	19	17	3	6	8	2	4	0	0	0.131	0.327	1.000
120	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY2(2)	1978370	4	4	4	0	2	1	1	0	0	0	0.267	0.331	1.000
121	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2L1(1), CBL(1), FOS(2), HRAS(1), IL2RB(1), IRS1(1), JAK1(1), MYC(1), PIK3CA(3), PIK3R1(1), PPIA(1), RAF1(1), SOCS1(1), SOS1(3), SYK(1)	8267642	20	19	19	4	3	7	3	4	3	0	0.296	0.334	1.000
122	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(2), STAT1(2)	2595545	5	5	5	0	1	3	0	0	1	0	0.259	0.336	1.000
123	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH3A1(2), MIOX(1)	1938548	4	4	4	0	1	3	0	0	0	0	0.240	0.339	1.000
124	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ALDH3B2(1), AOC3(1), DDC(2), HAL(1), MAOA(2)	5547710	11	10	11	1	3	6	1	0	1	0	0.0844	0.348	1.000
125	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), JAK1(1), STAT1(2), STAT3(1)	2775073	5	5	5	0	1	2	0	1	1	0	0.277	0.352	1.000
126	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12RB1(1), JAK2(2), TYK2(3)	3425893	6	6	6	0	3	3	0	0	0	0	0.112	0.360	1.000
127	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), EHHADH(1), SDHB(1)	1774291	3	3	3	1	0	1	1	0	1	0	0.662	0.362	1.000
128	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	RPL13A(1), RPL18(2), RPL19(2), RPL26(1), RPL3(1), RPL31(1), RPS5(1), RPS7(1)	4864979	10	10	9	1	5	4	0	0	1	0	0.178	0.362	1.000
129	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), DDHD1(2), ECHS1(1), EHHADH(1), GAD1(1), GAD2(1), HMGCL(1), HSD17B4(1), ILVBL(3), L2HGDH(1), PDHA1(1), PDHA2(1), PPME1(1), RDH13(2)	9360495	22	21	22	4	5	10	3	1	3	0	0.129	0.362	1.000
130	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(2), YARS(1), YARS2(1)	1948663	4	4	4	1	1	1	2	0	0	0	0.601	0.363	1.000
131	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(1), GABRA4(1), UBQLN1(2)	2888380	6	5	6	1	1	3	1	0	0	1	0.492	0.370	1.000
132	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLE(2), POLG(2), POLQ(1)	3816208	8	8	8	1	2	5	1	0	0	0	0.226	0.372	1.000
133	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPPL2(2), DHFR(1), FPGS(1)	1599117	5	5	5	2	0	1	0	2	2	0	0.730	0.377	1.000
134	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), SNCA(1), UBE2F(1)	1430197	3	3	3	1	0	1	1	0	1	0	0.812	0.390	1.000
135	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), RDH5(1)	862765	2	2	2	0	1	1	0	0	0	0	0.484	0.393	1.000
136	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(1), FOS(2), HRAS(1), JAK1(1), JAK2(2), RAF1(1), SOS1(3), STAT3(1)	5512915	13	12	13	3	4	4	1	2	2	0	0.425	0.410	1.000
137	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH4(1), ALDH1B1(1), ALDH3A1(2)	3010118	5	5	5	1	1	4	0	0	0	0	0.465	0.419	1.000
138	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A6(1), XDH(2)	1822508	3	3	3	0	1	1	0	0	1	0	0.458	0.420	1.000
139	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT7(1), ST3GAL2(1), ST3GAL4(1), WBSCR17(1)	3362158	6	6	6	0	0	4	0	1	1	0	0.152	0.421	1.000
140	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), FBP2(2), GALK1(1), GANAB(1), GLA(1), HK2(3), HK3(3), LCT(2), MGAM(1)	7412058	15	14	15	2	8	6	0	1	0	0	0.0836	0.422	1.000
141	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), FOS(2), HRAS(1), IL2RB(1), JAK1(1), RAF1(1), SOS1(3), SYK(1)	5495072	11	10	11	2	2	4	2	1	2	0	0.383	0.423	1.000
142	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), UGT1A10(1), UGT1A4(1), UGT2A3(1), UGT2B10(1), UGT2B11(1), UGT2B7(1), XYLB(1)	5846024	8	8	8	0	1	4	0	3	0	0	0.123	0.424	1.000
143	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	449528	1	1	1	0	0	1	0	0	0	0	0.717	0.424	1.000
144	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1B1(1), ALDH3A1(2), ALDH3B2(1), AOC3(1), DDC(2), HAL(1), HARS2(1), MAOA(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), WBSCR22(1)	9107949	17	16	17	1	3	12	1	0	1	0	0.0145	0.425	1.000
145	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(1), ERBB3(2), NRG1(1), UBE2D1(1)	2326934	5	5	5	1	0	5	0	0	0	0	0.498	0.426	1.000
146	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2E1(1), GTF2H1(3), GTF2I(1), GTF2IRD1(2), STON1(1), TAF10(1), TAF1L(1), TAF5(2), TAF5L(1), TAF6L(1), TAF7(2), TAF7L(1), TAF9B(1)	8407049	18	17	18	3	5	6	4	2	1	0	0.189	0.427	1.000
147	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH4(1)	1255622	2	2	2	1	0	2	0	0	0	0	0.852	0.432	1.000
148	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GLA(1), HEXA(1), ST3GAL2(1), ST3GAL4(1)	2300530	4	4	4	1	0	2	0	2	0	0	0.628	0.433	1.000
149	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), HIF1A(3), JAK2(2), RELA(1)	3029355	7	7	7	2	3	2	1	1	0	0	0.533	0.438	1.000
150	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	MAP3K14(1), RELA(1), TP53(2)	2332493	4	4	4	0	1	3	0	0	0	0	0.291	0.439	1.000
151	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), EP300(2), HIF1A(3), NOS3(1), VHL(1)	3880401	8	8	8	2	2	2	1	1	2	0	0.490	0.445	1.000
152	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(1), AXIN1(2), CREBBP(6), CSNK1A1(1), CSNK2A1(1), FZD1(1), MAP3K7(1), MYC(1), PPARD(1), WNT1(1)	6874987	16	16	16	3	4	9	1	1	1	0	0.224	0.446	1.000
153	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	PCYT1B(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), WBSCR22(1)	3201719	7	6	7	0	1	6	0	0	0	0	0.0953	0.448	1.000
154	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR2(1)	1412914	2	2	2	0	0	2	0	0	0	0	0.538	0.465	1.000
155	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSL(2), ADSS(3), AGXT2(1), CAD(1), GAD1(1), GAD2(1), GPT2(1), PC(2)	5965987	12	11	12	2	4	5	1	2	0	0	0.223	0.470	1.000
156	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(1), CEBPB(1), EGR1(2), LHCGR(3), MLH1(1), MSH5(1), NCOR1(1), PGR(4), PRLR(2), SMPD1(1), VDR(1), ZP2(1)	7869832	19	18	18	4	1	12	2	4	0	0	0.319	0.473	1.000
157	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1)	971155	2	2	2	0	0	2	0	0	0	0	0.564	0.475	1.000
158	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	380185	1	1	1	0	0	0	0	0	1	0	0.731	0.476	1.000
159	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), FBL(1), NCL(1)	2061044	3	3	3	1	0	1	1	0	1	0	0.840	0.477	1.000
160	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	HRAS(1), PIK3CA(3), PIK3R1(1)	2939253	5	5	4	1	0	4	0	1	0	0	0.534	0.479	1.000
161	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), WBSCR22(1)	3416070	6	6	6	0	1	4	1	0	0	0	0.135	0.480	1.000
162	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	HMGCR(2), LSS(2)	2551160	4	4	4	1	1	2	0	0	1	0	0.524	0.483	1.000
163	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH4(1), AKR1B1(1), ALDH1B1(1), ALDH3A1(2), CEL(3), DAK(4), DGKD(2), DGKG(1), DGKI(2), DGKQ(3), DGKZ(4), GK2(1), GLA(1), LCT(2), LIPC(2)	13543391	31	28	31	5	9	17	1	2	2	0	0.0316	0.484	1.000
164	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1)	882521	1	1	1	1	0	0	1	0	0	0	0.935	0.490	1.000
165	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	JAK1(1), JAK2(2), STAT1(2), STAT3(1), TYK2(3)	4349185	9	9	9	2	2	5	0	1	1	0	0.403	0.492	1.000
166	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT3(1), BLNK(1), BTK(1), CD19(1), CSK(2), MAP2K2(1), NFKB2(2), NFKBIB(1), NFKBIL1(2), PIK3CA(3), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RAF1(1), SOS1(3), SYK(1), VAV1(2)	12210272	28	25	26	4	7	13	4	2	2	0	0.0434	0.500	1.000
167	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), BST1(1), ENPP3(1), NADSYN1(1), NMNAT2(1), NNMT(1), NNT(1), NT5C1B(2), NUDT12(1), QPRT(1)	4932698	11	9	11	2	1	8	0	1	1	0	0.385	0.509	1.000
168	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	DIAPH1(3), HRAS(1), MYL2(1), PIK3CA(3), PIK3R1(1), PTK2(1), PXN(2), RAF1(1), ROCK1(1), TLN1(1)	8547891	15	15	14	2	2	11	0	2	0	0	0.169	0.511	1.000
169	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	JAK2(2), RELA(1), TNFRSF1A(1), TP53(2), USH1C(1)	4411466	7	7	7	1	2	4	1	0	0	0	0.290	0.512	1.000
170	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BIRC2(1), CASP3(1), FADD(1), MAP3K3(2), MAP3K7(1), NFKB2(2), NFKBIB(1), NFKBIL1(2), TNFAIP3(1), TNFRSF1A(1), TRAF2(1)	6585354	14	14	14	3	4	4	4	1	1	0	0.293	0.515	1.000
171	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(1), CDC25A(1), CDC25B(2), CDC25C(1), MYT1(1)	3116074	6	6	6	2	1	1	2	0	2	0	0.745	0.515	1.000
172	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGFR(1), HRAS(1), PTPRB(1), RAF1(1), SOS1(3), SPRY4(1)	5669588	9	8	9	1	1	3	1	2	2	0	0.310	0.518	1.000
173	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHKA(1), PDHA1(1), PDHA2(1)	1610375	3	3	3	1	1	2	0	0	0	0	0.617	0.527	1.000
174	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(1), ALDH3A1(2), CYP2C19(1), DHRS2(1), ECHS1(1), EHHADH(1), ESCO1(1), NAT6(1)	6952801	10	10	10	0	2	4	2	0	2	0	0.0529	0.528	1.000
175	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(1), ENPP3(1), FLAD1(1), MTMR6(1), TYR(1)	3463735	5	5	5	0	0	3	2	0	0	0	0.239	0.529	1.000
176	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1)	768882	1	1	1	1	0	1	0	0	0	0	0.935	0.531	1.000
177	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(2), MEF2A(3), MEF2B(1), MEF2C(1)	1983735	7	7	5	3	4	2	1	0	0	0	0.670	0.531	1.000
178	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), LDLR(1)	1201782	2	2	2	1	0	2	0	0	0	0	0.783	0.533	1.000
179	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FOS(2), HRAS(1), NFATC2(4), NFATC4(1), PIK3CA(3), PIK3R1(1), RAF1(1), SOS1(3), SYK(1), VAV1(2)	9783360	20	18	19	3	3	11	3	2	1	0	0.141	0.534	1.000
180	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(1), ACVR2A(1), ACVR2B(1), AMH(2), AMHR2(1), BMP7(1), BMP8B(1), BMPR1A(1), BMPR2(1), CHRD(1), CREBBP(6), E2F4(1), EP300(2), FST(1), GDF5(2), GDF6(2), ID4(1), INHBB(1), MYC(1), PPP2R1A(2), PPP2R2A(2), PPP2R2B(2), RBL1(1), RBL2(1), RHOA(1), ROCK1(1), ROCK2(1), SMAD4(1), SMAD6(2), SMAD7(2), SMAD9(1), SMURF1(1), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), THBS1(1), THBS3(1)	22644180	52	46	52	8	6	22	6	5	13	0	0.0460	0.536	1.000
181	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1)	810185	1	1	1	0	0	0	1	0	0	0	0.803	0.536	1.000
182	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	FADD(1), TNFRSF1A(1), TRAF2(1)	1914677	3	3	3	1	0	2	1	0	0	0	0.720	0.542	1.000
183	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GNAQ(1), HRAS(1), MAP2K2(1), PAK1(1), PTK2B(1), RAC1(4), RAF1(1), SOS1(3)	6508787	14	12	13	3	4	3	2	4	1	0	0.392	0.547	1.000
184	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	BCAR1(1), CSK(2), CTNNA2(1), PTK2(1), PXN(2), VCL(1)	4465383	8	8	8	0	2	6	0	0	0	0	0.0582	0.547	1.000
185	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(1)	1000312	1	1	1	1	1	0	0	0	0	0	0.921	0.557	1.000
186	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	PIK3CA(3), PIK3R1(1)	2864292	4	4	3	0	0	3	0	1	0	0	0.352	0.561	1.000
187	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ENPP3(1), FLAD1(1), TYR(1)	2236219	3	3	3	0	0	2	1	0	0	0	0.412	0.565	1.000
188	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	IL12RB1(1), JAK2(2), TYK2(3)	4293827	6	6	6	0	3	3	0	0	0	0	0.120	0.568	1.000
189	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(6), CSK(2), GNAS(1), PRKAR2B(2)	5271169	11	11	11	2	1	8	0	1	1	0	0.333	0.569	1.000
190	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(6), CSK(2), GNAS(1), PRKAR2B(2)	5271169	11	11	11	2	1	8	0	1	1	0	0.333	0.569	1.000
191	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	CREB5(1), RAF1(1), SNX13(1)	2648943	3	3	3	0	2	0	0	0	1	0	0.345	0.590	1.000
192	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT3(1), BLNK(1), BTK(1), CD19(1), CSK(2), INPP5D(1), ITPR1(4), ITPR2(3), ITPR3(5), NFATC2(4), PIK3CA(3), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RAF1(1), SOS1(3), SYK(1), VAV1(2)	16926917	39	33	37	5	7	17	7	4	4	0	0.0163	0.591	1.000
193	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	HMGCR(2), LSS(2)	3024744	4	4	4	1	1	2	0	0	1	0	0.545	0.591	1.000
194	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(1), AXIN1(2), DLL1(1), FZD1(1), NOTCH1(5), WNT1(1)	5054229	12	12	12	3	3	4	2	0	3	0	0.318	0.594	1.000
195	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(1), EHHADH(1)	1926762	2	2	2	1	0	0	1	0	1	0	0.761	0.602	1.000
196	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNE1(1), SKP2(1), TFDP1(1)	1976370	3	3	3	1	0	2	0	1	0	0	0.763	0.602	1.000
197	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(2), PPP1CA(1), PRKAR2B(2)	3784921	5	5	5	0	0	3	1	0	1	0	0.357	0.602	1.000
198	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	NR3C1(1), PPARG(1)	1293422	2	2	2	0	0	1	0	0	1	0	0.714	0.603	1.000
199	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), LRP8(2), RELN(2)	3136351	5	5	5	1	0	4	1	0	0	0	0.539	0.603	1.000
200	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), GPI(1), PGAM1(1)	2083166	3	3	3	0	1	1	1	0	0	0	0.376	0.606	1.000
201	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), CYP19A1(1), HSD3B1(1), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), STS(1), UGT1A10(1), UGT1A4(1), UGT2A3(1), UGT2B10(1), UGT2B11(1), UGT2B7(1), WBSCR22(1)	11097853	15	15	15	0	2	9	1	3	0	0	0.0113	0.607	1.000
202	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HSD17B4(1), MECR(2), PPT2(1)	1949523	5	5	5	3	0	2	1	0	2	0	0.917	0.615	1.000
203	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), IL11(1)	1441422	2	2	2	1	0	2	0	0	0	0	0.749	0.617	1.000
204	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(3), PIK3R1(1), VAV1(2)	2923384	6	6	5	2	1	4	0	1	0	0	0.652	0.629	1.000
205	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ACY3(1), ADSL(2), ADSS(3), AGXT2(1), ASRGL1(2), CAD(1), DARS2(1), GAD1(1), GAD2(1), GPT2(1), PC(2), PDHA1(1), PDHA2(1)	8692955	18	16	18	3	6	9	1	2	0	0	0.126	0.632	1.000
206	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(1), NOS3(1), NR3C1(1), PIK3CA(3), PIK3R1(1), RELA(1)	4199852	8	8	7	2	0	6	0	2	0	0	0.567	0.645	1.000
207	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), KEAP1(1), NFE2L2(2)	2116443	5	4	5	2	2	3	0	0	0	0	0.642	0.653	1.000
208	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), IFNAR1(1), IFNAR2(1), RELA(1)	2489816	5	5	5	2	0	4	1	0	0	0	0.731	0.655	1.000
209	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	EBP(1), HMGCR(2), LSS(2), TM7SF2(1)	4435335	6	6	6	1	1	3	0	0	2	0	0.335	0.656	1.000
210	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ATM(1), CSNK1A1(1), HIF1A(3), NFKBIB(1), TP53(2)	4937768	8	8	8	2	3	2	2	0	1	0	0.477	0.659	1.000
211	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EGFR(1), HGS(2), TFRC(1)	2887638	4	4	4	1	0	4	0	0	0	0	0.607	0.660	1.000
212	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	MYC(1), PIK3CA(3), PIK3R1(1), RAC1(4), TP53(2), TWIST1(2)	4563906	13	13	11	4	2	5	2	4	0	0	0.573	0.661	1.000
213	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	1156687	1	1	1	0	0	0	1	0	0	0	0.850	0.665	1.000
214	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), DHRS2(1), ECHS1(1), EHHADH(1), ESCO1(1), FN3K(1), NAT6(1)	5842769	7	7	7	1	1	1	3	0	2	0	0.379	0.667	1.000
215	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(1), CES2(2), UGT1A10(1), UGT1A4(1)	5154830	6	6	6	1	1	2	2	1	0	0	0.404	0.671	1.000
216	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	PAPSS2(1), SULT1A2(1)	1904312	2	2	2	0	1	0	0	0	1	0	0.602	0.682	1.000
217	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHB1(2), RAP1B(1), SELP(1)	3534956	5	5	5	0	0	4	1	0	0	0	0.223	0.684	1.000
218	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GPRC5B(1), GPRC5C(1), GRM1(2), GRM4(2), GRM5(2), GRM8(2)	4719521	11	11	11	3	2	5	1	2	1	0	0.375	0.685	1.000
219	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), GALK1(1), GLA(1), HK2(3), HK3(3), LCT(2), MGAM(1), RDH13(2)	8770313	14	14	14	2	8	4	0	2	0	0	0.119	0.688	1.000
220	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), UCHL1(1), UGT1A10(1), UGT1A4(1)	3926378	4	4	4	0	1	1	0	1	1	0	0.297	0.690	1.000
221	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), PRKAR2B(2)	2274756	3	3	3	1	0	2	0	1	0	0	0.780	0.691	1.000
222	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2A(1), CAMK2D(1), CAMK4(3), CAMKK1(2)	2741130	7	7	7	3	1	3	1	0	2	0	0.781	0.702	1.000
223	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP2C19(1), CYP2J2(1), PLA2G6(1), RDH13(2)	5537332	7	7	7	1	4	2	0	1	0	0	0.272	0.708	1.000
224	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	PDPK1(1), PIK3CA(3), PIK3R1(1), RELA(1)	3345837	6	6	5	2	1	4	0	1	0	0	0.674	0.709	1.000
225	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4G1(2), EIF4G2(1), EIF4G3(2), IRS1(1), PABPC1(1), PDK2(1), PDPK1(1), PIK3CA(3), PIK3R1(1)	6440275	13	13	12	3	3	7	0	3	0	0	0.434	0.710	1.000
226	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), BIN1(1), DNM1(2), EPN1(1), PICALM(1), SYNJ1(1), SYNJ2(2)	5229013	9	9	9	2	2	6	0	0	1	0	0.394	0.719	1.000
227	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A4(1), COL4A5(2), COL4A6(1), SLC23A1(2), SLC23A2(1), SLC2A1(2), SLC2A3(1)	5909123	12	10	12	2	3	7	2	0	0	0	0.197	0.722	1.000
228	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), ENO3(1), FBP2(2), GPI(1), HK2(3), HK3(3), PDHA1(1), PDHA2(1), PGAM1(1)	11037729	21	19	21	3	10	10	1	0	0	0	0.0419	0.723	1.000
229	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), ENO3(1), FBP2(2), GPI(1), HK2(3), HK3(3), PDHA1(1), PDHA2(1), PGAM1(1)	11037729	21	19	21	3	10	10	1	0	0	0	0.0419	0.723	1.000
230	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(1), JAK2(2), STAT3(1)	3524536	4	4	4	1	1	1	0	1	1	0	0.709	0.724	1.000
231	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACADVL(1), CPT1A(1), CPT2(1), EHHADH(1), PECR(1)	3796897	7	7	7	2	1	3	1	1	1	0	0.652	0.727	1.000
232	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2D1(1), UBE2D3(1), UBE2M(2), UBE3A(1)	2405459	5	5	5	2	0	5	0	0	0	0	0.738	0.732	1.000
233	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	CREB5(1), CREBBP(6), EGR1(2), EGR2(1), EGR3(1), EGR4(1), FRS2(1), GNAQ(1), MAP1B(2), MAPK10(1), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), NTRK1(1), PIK3C2G(2), PIK3CA(3), PIK3CD(4), PIK3R1(1), TH(1)	12110652	37	31	35	8	4	20	6	4	3	0	0.139	0.736	1.000
234	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(1), ATR(2), CDC25C(1), TP53(2)	3536124	6	6	6	2	1	2	3	0	0	0	0.696	0.736	1.000
235	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADL(1), ACADM(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), AOX1(1), BCKDHB(1), ECHS1(1), EHHADH(1), HMGCL(1), PCCA(3)	8243794	14	14	14	3	2	7	2	1	2	0	0.288	0.739	1.000
236	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP19(1), SRP68(1), SRP9(1), SRPR(2)	1686968	5	5	5	4	1	2	0	1	1	0	0.939	0.743	1.000
237	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	PDHA1(1), PDHA2(1)	2249678	2	2	2	1	1	1	0	0	0	0	0.802	0.747	1.000
238	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT3(1), INPP5D(1), JAK1(1), JAK2(2), PIK3CA(3), PPP1R13B(1), SOS1(3), TYK2(3)	8437875	15	12	14	3	2	7	1	3	2	0	0.394	0.748	1.000
239	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1)	1093025	1	1	1	1	0	1	0	0	0	0	0.929	0.752	1.000
240	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ7(1)	991162	1	1	1	1	0	1	0	0	0	0	0.939	0.753	1.000
241	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3A1(2), ALDH3B2(1), AOC3(1), DDC(2), MAOA(2), MPO(1)	5013835	9	8	9	2	3	4	1	0	1	0	0.296	0.753	1.000
242	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), CDC25C(1), GNAS(1), HRAS(1), MYT1(1), PRKAR2B(2), RPS6KA1(2)	4764497	9	9	9	2	1	5	1	1	1	0	0.476	0.756	1.000
243	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(2), HRAS(1), MYC(1), RAF1(1), RELA(1)	3493752	6	6	6	2	1	4	0	1	0	0	0.598	0.756	1.000
244	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1)	1520083	1	1	1	1	1	0	0	0	0	0	0.931	0.760	1.000
245	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), RELA(1), TNFRSF13C(1), TRAF2(1), TRAF3(1)	3285938	5	4	5	0	0	5	0	0	0	0	0.218	0.760	1.000
246	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	SP1(1)	1532165	1	1	1	1	0	0	1	0	0	0	0.941	0.761	1.000
247	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(1), FASN(2)	3788194	4	4	4	0	1	0	2	0	1	0	0.300	0.761	1.000
248	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2A(1), CAMK2D(1), GNAS(1), HRAS(1), PIK3CA(3), PIK3R1(1), PRKAR2B(2), RAC1(4), RPS6KA1(2), RPS6KA5(1), SOS1(3)	6750963	20	18	18	5	2	8	2	6	2	0	0.485	0.767	1.000
249	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ANKRD1(1), IFRD1(2)	2516939	3	3	3	1	0	2	0	0	1	0	0.829	0.770	1.000
250	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	CHST12(1), PAPSS2(1), SULT1A2(1)	2653032	3	3	3	1	2	0	0	0	1	0	0.708	0.772	1.000
251	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1)	1187997	1	1	1	0	0	1	0	0	0	0	0.700	0.774	1.000
252	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHA(2), SDHB(1)	1462970	3	3	3	2	0	2	0	0	1	0	0.889	0.775	1.000
253	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(3)	1755396	3	3	3	2	0	2	0	1	0	0	0.914	0.784	1.000
254	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), RECK(1)	1744391	2	2	2	0	1	1	0	0	0	0	0.469	0.788	1.000
255	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1B(1), ADH4(1), ALDH1B1(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), ENO3(1), FBP2(2), GAPDHS(1), GPI(1), HK2(3), HK3(3), LDHAL6A(1), PDHA1(1), PDHA2(1), PGAM1(1)	13197728	22	21	22	3	9	11	1	0	1	0	0.0328	0.789	1.000
256	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	GNAS(1), XPO1(1)	2205721	2	2	2	1	0	0	0	2	0	0	0.923	0.790	1.000
257	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C5(2), C7(1)	2876230	3	3	3	0	0	3	0	0	0	0	0.420	0.800	1.000
258	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2)	3217624	3	3	3	1	1	1	0	0	1	0	0.793	0.800	1.000
259	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), FOS(2), HRAS(1), JAK2(2), RAF1(1), SOS1(3)	5046597	10	9	10	3	3	4	1	1	1	0	0.538	0.802	1.000
260	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), TFDP1(1)	1925881	2	2	2	1	0	1	0	1	0	0	0.881	0.802	1.000
261	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1B(1), ADH4(1), DHRS2(1), ESCO1(1), NAT6(1)	5576170	6	6	6	1	0	4	1	0	1	0	0.533	0.804	1.000
262	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), IDH3A(1), PC(2), PCK1(1), SDHA(2), SDHB(1), SUCLG2(2)	4663997	10	10	10	3	1	8	0	0	1	0	0.480	0.804	1.000
263	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(1), HSD17B4(1), SIRT2(1), SIRT5(1), SIRT7(1)	2703727	6	6	6	3	1	2	2	0	1	0	0.800	0.807	1.000
264	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1)	1216892	1	1	1	0	0	1	0	0	0	0	0.689	0.807	1.000
265	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), SDHB(1)	2024322	2	2	2	0	0	2	0	0	0	0	0.537	0.811	1.000
266	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(1), PRKAA2(1)	3237419	3	3	3	1	1	1	1	0	0	0	0.696	0.811	1.000
267	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	IDH3A(1), PC(2), PDHA1(1), PDHA2(1), PDK2(1), PDP2(1), SDHA(2), SDHB(1), SUCLG2(2)	6474270	12	12	12	3	3	7	0	0	2	0	0.339	0.812	1.000
268	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	SDHA(2)	2141258	2	2	2	1	0	1	0	0	1	0	0.784	0.814	1.000
269	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	MAP3K14(1), RELA(1), TANK(1), TNFAIP3(1), TRAF2(1), TRAF3(1)	5297201	6	6	6	1	1	4	0	1	0	0	0.416	0.818	1.000
270	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA6(1), PSMD11(4), PSMD6(1)	3628718	6	5	3	2	4	1	0	0	1	0	0.658	0.818	1.000
271	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1)	1440347	1	1	1	0	0	1	0	0	0	0	0.761	0.820	1.000
272	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(1), PTGES(1)	3633290	8	8	8	3	4	2	1	0	1	0	0.632	0.829	1.000
273	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TGFB1(1), TGFBR3(1)	2436555	2	2	2	1	0	1	1	0	0	0	0.858	0.832	1.000
274	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1)	1536332	1	1	1	1	0	0	0	1	0	0	0.964	0.832	1.000
275	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHPF(1), CHST12(1), CHST3(1), UST(1), XYLT1(1)	3325924	6	6	6	2	3	2	0	0	1	0	0.503	0.834	1.000
276	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), SREBF1(4), SREBF2(1)	2909210	6	6	6	4	0	2	1	1	1	1	0.937	0.838	1.000
277	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(1), ALPI(1), ALPPL2(2), DHRS2(1), PON1(1)	4204671	6	6	6	2	0	0	2	2	2	0	0.734	0.841	1.000
278	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), ESCO1(1), NAT6(1)	3669703	3	3	3	0	0	1	1	0	1	0	0.569	0.844	1.000
279	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(2), AKT3(1), CAMK2A(1), CAMK2D(1), CBL(1), CBLC(1), CRK(1), EGFR(1), ERBB2(3), ERBB3(2), GAB1(1), HRAS(1), KRAS(19), MAP2K2(1), MAPK10(1), MYC(1), NRAS(7), NRG1(1), PAK1(1), PAK3(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PTK2(1), RAF1(1), SOS1(3)	23950649	64	49	46	11	3	31	12	13	5	0	0.0258	0.847	1.000
280	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	MPO(1), TYR(1)	2213382	2	2	2	1	1	1	0	0	0	0	0.775	0.849	1.000
281	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(2), GNAS(1), PRKAR2B(2)	3029436	5	5	5	2	0	2	1	2	0	0	0.808	0.849	1.000
282	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), IL11(1), TGFB1(1)	3126586	3	3	3	0	0	3	0	0	0	0	0.334	0.849	1.000
283	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	XYLT1(1)	1553853	1	1	1	1	0	0	0	0	1	0	0.883	0.851	1.000
284	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	XYLT1(1)	1553853	1	1	1	1	0	0	0	0	1	0	0.883	0.851	1.000
285	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	MAP3K14(1), MAP4K2(1), RELA(1), TANK(1), TNFRSF1A(1), TRAF2(1)	5735810	6	6	6	1	1	3	1	1	0	0	0.426	0.851	1.000
286	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PTK2B(1)	1532099	1	1	1	0	1	0	0	0	0	0	0.699	0.852	1.000
287	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(1), ITGAM(1), ITGB2(3), SELL(1)	2450351	6	6	6	3	1	3	0	1	1	0	0.753	0.852	1.000
288	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), EGR3(1), GNAQ(1), MYC(1), NFATC2(4), PRKAR2B(2), RELA(1)	6381191	11	10	11	3	1	6	1	2	1	0	0.547	0.854	1.000
289	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(2), HRAS(1), PTK2(1), RAF1(1), SYK(1)	5471417	6	6	6	1	1	4	1	0	0	0	0.393	0.855	1.000
290	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA6(1)	1990045	1	1	1	2	0	0	0	0	1	0	1.000	0.856	1.000
291	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(6), EP300(2), PRKAR2B(2), RARA(1)	4668399	11	11	11	4	0	8	1	0	2	0	0.737	0.856	1.000
292	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(2), CREBBP(6), EP300(2), FZD1(1), TRRAP(1), WNT1(1)	7499829	14	13	14	3	2	8	2	0	2	0	0.315	0.858	1.000
293	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), BDKRB2(1), NOS3(1)	2326673	4	4	4	2	2	2	0	0	0	0	0.699	0.859	1.000
294	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(1), CDC25A(1), CDC25B(2), CDC25C(1), MYT1(1), TP53(2)	3996343	8	8	8	3	2	2	2	0	2	0	0.763	0.859	1.000
295	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1)	2044130	1	1	1	0	0	0	1	0	0	0	0.772	0.861	1.000
296	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), GREB1(1), MTA3(1)	2626128	4	4	4	2	2	1	1	0	0	0	0.782	0.861	1.000
297	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1)	2860581	7	7	7	5	1	3	1	0	2	0	0.946	0.861	1.000
298	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ALPI(1), ALPPL2(2), CYP19A1(1), CYP1A1(2), CYP2A6(1), CYP2C19(1), CYP2D6(1), CYP2J2(1), CYP4B1(1), PON1(1)	6731194	12	12	12	3	0	5	1	2	4	0	0.444	0.861	1.000
299	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	FASN(2), PECR(1)	3549929	3	3	3	1	2	0	1	0	0	0	0.660	0.865	1.000
300	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(1), ARF1(1), BTK(1), PDPK1(1), RAC1(4)	5627336	8	8	7	2	3	2	1	2	0	0	0.482	0.870	1.000
301	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), GRM1(2), PPP1CA(1), PRKAR2B(2)	3653809	6	6	6	2	0	4	1	1	0	0	0.639	0.872	1.000
302	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(1), HS6ST1(1), HS6ST2(1), NDST1(2)	4815651	5	5	5	1	2	0	1	0	2	0	0.599	0.872	1.000
303	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(1), COPA(1)	3682391	3	3	3	1	1	0	0	1	1	0	0.839	0.874	1.000
304	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK4(1), PPP1CA(1)	2621608	2	2	2	1	0	1	1	0	0	0	0.850	0.876	1.000
305	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	MAP3K14(1), RELA(1), TNFAIP3(1), TRAF3(1)	4342141	4	4	4	0	0	3	0	1	0	0	0.340	0.877	1.000
306	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ENO3(1), FBP2(2), GAPDHS(1), GPI(1), HK2(3), HK3(3), PC(2), PCK1(1), PDHA1(1), PDHA2(1), PGAM1(1)	9526706	18	16	18	4	8	8	1	0	1	0	0.164	0.879	1.000
307	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), TUB(2)	1603557	5	5	5	3	2	2	0	1	0	0	0.848	0.881	1.000
308	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY8(1), CACNA1A(2), GNAS(1), GNAT3(1), GRM4(2), ITPR3(5), PLCB2(1), SCNN1A(2), TAS1R1(1), TAS1R3(5), TAS2R1(1), TAS2R40(1), TAS2R43(1), TAS2R46(1), TAS2R8(1), TRPM5(3)	13374122	29	27	29	6	5	12	4	4	4	0	0.145	0.886	1.000
309	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	ATF2(1), EGFR(1), GNAQ(1), HRAS(1), MAP2K2(1), MEF2A(3), MEF2B(1), MEF2C(1), PAK1(1), PTK2(1), PTK2B(1), RAC1(4), RAF1(1), SOS1(3)	7802240	21	20	18	6	7	7	2	4	1	0	0.450	0.887	1.000
310	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AMY1A(1), ENPP3(1), GANAB(1), GPI(1), GYS1(3), GYS2(2), HK2(3), HK3(3), MGAM(1), PYGB(2), RNPC3(1), SI(2), UCHL1(1), UGT1A10(1), UGT1A4(1)	15288336	24	21	24	4	10	8	1	3	2	0	0.0941	0.894	1.000
311	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), MPO(1)	2700369	2	2	2	1	1	0	0	0	1	0	0.770	0.895	1.000
312	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), TP53(2)	1898788	3	3	3	2	2	1	0	0	0	0	0.845	0.897	1.000
313	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(2), CAMK4(3), CD69(1), CEBPB(1), CREBBP(6), CSNK2A1(1), CSNK2B(1), EGR2(1), EGR3(1), EP300(2), FCGR3A(1), FOS(2), GATA3(1), HRAS(1), MEF2A(3), MEF2B(1), NFATC2(4), NFATC4(1), NFKB2(2), NFKBIB(1), OPRD1(1), PAK1(1), PPIA(1), RELA(1), RPL13A(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(3), VAV1(2), VAV3(1)	21114747	50	41	48	9	11	28	5	1	5	0	0.0208	0.899	1.000
314	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), ATF2(1), AXIN1(2), BMP7(1), BMPR1A(1), BMPR2(1), CHRD(1), FZD1(1), MAP3K7(1), MEF2C(1), MYL2(1), NKX2-5(1), TGFB1(1), TGFBR3(1), WNT1(1)	8373431	16	16	16	4	5	9	2	0	0	0	0.329	0.904	1.000
315	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB11(1), ABCB4(1), ABCC1(1)	3273084	3	3	3	0	0	2	0	1	0	0	0.409	0.907	1.000
316	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	MPO(1)	1909176	1	1	1	1	1	0	0	0	0	0	0.904	0.909	1.000
317	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1B1(1), ALDH3A1(2), AOC3(1), CPS1(3), MAOA(2), SAT1(1), SMS(1)	6719367	12	12	12	4	1	6	1	3	1	0	0.582	0.913	1.000
318	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	FUT8(1), MAN1B1(1), MGAT3(2), MGAT4B(2)	4657573	6	6	6	2	2	1	2	1	0	0	0.634	0.917	1.000
319	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CSK(2), LCP2(1), NFKB2(2), NFKBIB(1), NFKBIL1(2), PAK1(1), PAK3(1), RAF1(1), RASGRP1(1), RASGRP4(1), SOS1(3), VAV1(2)	13190950	19	17	19	3	5	7	2	1	4	0	0.123	0.919	1.000
320	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLB(1), POLD1(2), POLD3(1), POLE(2), POLE4(1), POLG(2), POLK(1), POLQ(1), REV3L(1)	9442488	15	15	15	3	2	10	3	0	0	0	0.297	0.920	1.000
321	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(1), HSD3B1(1), STS(1), UGT1A10(1), UGT1A4(1)	6153612	6	5	6	0	1	3	1	1	0	0	0.161	0.923	1.000
322	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), CAMK4(3), CREBBP(6), CSNK1A1(1), ELSPBP1(2), HRAS(1), LIF(1), MEF2C(1), NFATC2(4), NFATC4(1), NKX2-5(1), PIK3CA(3), PIK3R1(1), PRKAR2B(2), RAF1(1)	11509915	29	26	28	6	4	20	3	1	1	0	0.153	0.923	1.000
323	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	HLA-A(1), ITGAL(1), ITGB2(3)	1959422	5	5	5	3	1	2	0	1	1	0	0.795	0.924	1.000
324	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL16(1)	2250530	1	1	1	0	0	1	0	0	0	0	0.714	0.926	1.000
325	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), F2RL3(2), MAPK7(3), MYEF2(1), PTK2(1), RAF1(1), RASAL1(2), VAV1(2)	6311525	14	14	13	4	2	10	2	0	0	0	0.378	0.929	1.000
326	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	CREB5(1), DUSP4(4), DUSP9(1), EEF2K(1), MAP2K2(1), MKNK2(2), MOS(1), RPS6KA1(2), SOS1(3), TRAF3(1)	6867763	17	16	17	5	7	4	2	1	3	0	0.432	0.929	1.000
327	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), CAMK2A(1), CAMK2D(1), CREB3L3(1), CREBBP(6), EP300(2), FZD1(1), FZD4(1), FZD8(3), GNAQ(1), GNAS(1), HRAS(1), KIT(27), KRAS(19), MAP2K2(1), MC1R(1), NRAS(7), PLCB2(1), PLCB3(2), RAF1(1), TYR(1), TYRP1(1), WNT1(1), WNT11(2), WNT3(1), WNT4(1), WNT5B(2), WNT8B(2), WNT9B(1)	25200033	97	71	68	22	13	38	16	24	6	0	0.0389	0.933	1.000
328	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	PDE1B(1), PLCB2(1)	2530484	2	2	2	3	0	1	0	0	1	0	0.971	0.935	1.000
329	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	GALNT1(1), GALNT10(1), GALNT7(1), GALNTL5(1), OGT(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(1)	7307102	9	9	9	2	0	5	1	2	1	0	0.493	0.937	1.000
330	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	IL12RB1(1)	2856519	1	1	1	1	1	0	0	0	0	0	0.907	0.938	1.000
331	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGFR(1), PDGFRA(1)	4376879	3	3	3	1	1	1	0	0	1	0	0.669	0.938	1.000
332	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	GNAS(1), PLCE1(2), PRKAR2B(2)	3416519	5	5	5	2	0	4	0	1	0	0	0.747	0.941	1.000
333	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO1(1)	3028510	2	2	2	0	0	2	0	0	0	0	0.519	0.944	1.000
334	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), DDHD1(2), ESCO1(1), NAT6(1), PPME1(1)	5747022	6	6	6	2	0	2	2	0	2	0	0.718	0.946	1.000
335	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A4(1), COL4A5(2), COL4A6(1), F12(2), F5(1), F8(2)	10236940	11	10	11	1	2	7	1	0	1	0	0.164	0.947	1.000
336	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	GABARAPL1(1), IFNA7(1), PRKAA2(1), ULK1(2)	4901750	5	5	5	2	2	1	0	2	0	0	0.753	0.947	1.000
337	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	CASP3(1), FCGR3A(1), HLA-A(1), HLA-C(2), HRAS(1), IFNA7(1), IFNAR1(1), IFNAR2(1), ITGAL(1), ITGB2(3), KIR3DL1(1), KLRC3(2), KRAS(19), LCP2(1), MAP2K2(1), MICB(1), NFATC2(4), NFATC4(1), NRAS(7), PAK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP3R2(1), PTK2B(1), RAC1(4), RAF1(1), SOS1(3), SYK(1), ULBP2(1), ULBP3(1), VAV1(2), VAV3(1)	26209276	78	60	60	15	8	35	17	16	2	0	0.0259	0.950	1.000
338	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	COL4A1(1), COL4A2(1), COL4A4(1), COL4A5(2), COL4A6(1)	5879939	6	5	6	1	1	5	0	0	0	0	0.475	0.951	1.000
339	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), EPRS(2), HMOX2(1), UGT1A10(1), UGT1A4(1)	6142785	6	6	6	2	1	2	1	1	1	0	0.616	0.952	1.000
340	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO3(1), YARS(1)	1847522	2	1	2	1	0	2	0	0	0	0	0.783	0.952	1.000
341	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(1), IL12RB1(1), TGFB1(1)	4595410	3	3	3	1	1	2	0	0	0	0	0.626	0.952	1.000
342	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(1), ITGB2(3), THY1(1)	2388310	5	5	5	3	1	3	0	0	1	0	0.798	0.953	1.000
343	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2)	3018098	2	2	2	0	0	2	0	0	0	0	0.547	0.953	1.000
344	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), AXIN1(2), FBXW2(1), FZD1(1), FZD8(3), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(1), PRKCH(2), PRKCI(1), RAC1(4), RHOA(1), WNT1(1), WNT11(2), WNT3(1), WNT4(1), WNT5B(2)	13328365	27	26	26	6	8	8	3	4	4	0	0.203	0.954	1.000
345	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	PLA2G6(1)	2459337	1	1	1	1	1	0	0	0	0	0	0.903	0.954	1.000
346	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), CASP3(1), DFFB(1), SREBF1(4), SREBF2(1)	4329483	8	8	8	9	0	2	3	1	1	1	0.998	0.955	1.000
347	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	FADD(1), NSMAF(1), RAF1(1), RELA(1), SMPD1(1), TNFRSF1A(1), TRAF2(1)	4662971	7	7	7	3	1	4	1	1	0	0	0.764	0.955	1.000
348	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASRGL1(2), CPS1(3), GLUD2(1), HAL(1)	4760052	7	7	7	3	2	4	0	1	0	0	0.736	0.956	1.000
349	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA6(1), UBE3A(1)	3006400	2	2	2	3	0	1	0	0	1	0	0.995	0.956	1.000
350	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL11(1), TGFB1(1)	1974768	3	3	3	2	0	2	0	0	1	0	0.819	0.958	1.000
351	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(1), ITGB2(3), THY1(1)	2523238	5	5	5	3	1	3	0	0	1	0	0.797	0.960	1.000
352	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATIC(1), ATP6V0C(1), DHFR(1), MTHFD1L(1), MTHFR(1)	4051543	6	6	6	3	2	2	0	0	2	0	0.824	0.960	1.000
353	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG13(1), ALG8(1), ALG9(2), DOLPP1(1), FUT8(1), GANAB(1), MAN1B1(1), MAN1C1(1), MGAT3(2), MGAT4B(2), MGAT5B(1), STT3B(1)	9845340	15	13	15	3	4	5	2	1	3	0	0.254	0.960	1.000
354	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(2)	3144795	2	2	2	1	0	2	0	0	0	0	0.766	0.961	1.000
355	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP2(2), GPT2(1), ME1(1), TKT(1), TKTL1(1)	4619340	7	7	7	3	0	3	1	2	1	0	0.778	0.961	1.000
356	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(1), G6PD(1), GGT1(1), GPX1(1), GSR(2), GSTA4(1), GSTK1(1), OPLAH(4)	5340250	12	9	10	4	1	8	2	1	0	0	0.489	0.962	1.000
357	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH3A1(2), ALDH3B2(1), AOC3(1), DDC(2), ESCO1(1), MAOA(2), MPO(1), NAT6(1)	7707549	11	10	11	3	3	5	1	0	2	0	0.440	0.965	1.000
358	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), HEXA(1), LCT(2), MAN2C1(2), NEU1(1), NEU4(1)	3904961	8	8	8	4	0	7	0	0	1	0	0.788	0.967	1.000
359	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), RELA(1), TRAF2(1)	4554861	3	3	3	1	0	3	0	0	0	0	0.784	0.968	1.000
360	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), ANAPC11(1), ANAPC2(1), CDC23(1), CDC27(6), CUL2(1), CUL3(1), FZR1(2), SKP2(1), SMURF1(1), SMURF2(1), TCEB2(1), UBE2D1(1), UBE2D3(1), VHL(1)	9427248	21	19	19	6	2	8	5	0	6	0	0.459	0.968	1.000
361	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	PIK3CA(3), PIK3R1(1), PTK2(1), PTK2B(1)	3802778	6	6	5	3	1	4	0	1	0	0	0.761	0.969	1.000
362	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), CKMT1B(1), CPS1(3), SMS(1)	4240713	6	6	6	3	0	4	0	2	0	0	0.832	0.970	1.000
363	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGAL(1), ITGB2(3), SELL(1)	2778776	6	6	6	5	2	2	0	1	1	0	0.941	0.970	1.000
364	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(1), CACNA1C(4), CAMK2A(1), CAMK2D(1), CAMK4(3), CREBBP(6), EP300(2), GNAQ(1), GRIA1(2), GRIN2A(1), GRIN2B(2), GRIN2D(2), GRM1(2), GRM5(2), HRAS(1), ITPR1(4), ITPR2(3), ITPR3(5), KRAS(19), MAP2K2(1), NRAS(7), PLCB2(1), PLCB3(2), PPP1CA(1), PPP1R12A(1), PPP3R2(1), RAF1(1), RAP1B(1), RAPGEF3(3), RPS6KA1(2), RPS6KA6(1)	23427829	84	64	69	18	14	37	13	12	8	0	0.0265	0.972	1.000
365	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K2(1), PIK3CA(3), PIK3R1(1), RELA(1), SP1(1)	4481216	7	7	6	3	1	4	1	1	0	0	0.785	0.973	1.000
366	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(1), CD14(1), CD19(1), CD1C(1), CD1E(1), CD9(1), CR1(3), CSF1(1), CSF2RA(1), CSF3R(2), FLT3(1), FLT3LG(2), IL11(1), IL3RA(1), IL7R(1), IL9R(2), ITGA2B(3), ITGA3(1), ITGA4(1), ITGAM(1), ITGB3(1), KIT(27), TFRC(1)	19218345	56	47	42	13	4	22	8	19	3	0	0.197	0.973	1.000
367	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	GLA(1), HEXA(1), ST3GAL2(1)	2436046	3	3	3	2	0	1	0	2	0	0	0.899	0.974	1.000
368	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), PRKAA2(1), PRKAR2B(2)	3560665	4	4	4	2	1	2	0	1	0	0	0.831	0.975	1.000
369	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ATP6V0C(1), DOT1L(2), ECHS1(1), EHHADH(1), EHMT1(2), EHMT2(1), PLOD1(1), PLOD2(1)	8378556	14	13	14	4	2	6	1	0	5	0	0.422	0.976	1.000
370	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(1), G6PD(1), GGT1(1), GPX1(1), GSTA4(1), PGD(2)	4369642	7	6	7	3	1	4	1	0	1	0	0.647	0.976	1.000
371	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B2(1), EIF2B3(1), FLT1(1), FLT4(1), HIF1A(3), HRAS(1), NOS3(1), PIK3CA(3), PIK3R1(1), PTK2(1), PXN(2), VHL(1)	7922428	18	16	17	5	3	10	2	2	1	0	0.389	0.978	1.000
372	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IRS1(1), JAK1(1)	3363533	2	2	2	3	1	0	0	0	1	0	0.992	0.980	1.000
373	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP2(2), GPT2(1), ME1(1), TKT(1)	4146814	6	6	6	3	0	3	1	2	0	0	0.846	0.981	1.000
374	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP29(1), STX5(1), TSNARE1(1), YKT6(1)	3914227	4	4	4	2	1	3	0	0	0	0	0.783	0.982	1.000
375	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT3(1), BTK(1), CD19(1), GAB1(1), ITPR1(4), ITPR2(3), ITPR3(5), PIK3CA(3), PPP1R13B(1), PREX1(2), RPS6KA1(2), SAG(1), SYK(1), VAV1(2)	12690898	28	23	27	6	5	14	3	2	4	0	0.144	0.982	1.000
376	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT3(1), ARHGAP1(1), ARHGAP4(2), BTK(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(5), MYLK2(1), PAK1(1), PAK3(1), PIK3CA(3), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RACGAP1(1), RHO(1), ROCK1(1), ROCK2(1), SAG(1), WASL(2)	16257926	37	30	35	8	5	18	5	5	4	0	0.153	0.982	1.000
377	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(1), CAD(1), CPS1(3), EPRS(2), GAD1(1), GAD2(1), GPT2(1), NADSYN1(1)	7557020	12	12	12	4	1	7	0	3	1	0	0.613	0.982	1.000
378	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT3(1), BTK(1), INPP5D(1), PIK3CA(3), PPP1R13B(1), RPS6KA1(2), SOS1(3), YWHAG(1), YWHAQ(1), YWHAZ(1)	8165439	15	12	14	4	1	7	2	3	2	0	0.553	0.982	1.000
379	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1)	3437728	6	4	6	4	2	3	0	0	1	0	0.870	0.984	1.000
380	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1)	3437728	6	4	6	4	2	3	0	0	1	0	0.870	0.984	1.000
381	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1)	3437728	6	4	6	4	2	3	0	0	1	0	0.870	0.984	1.000
382	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), DYRK1B(2), GLI3(1), PRKAR2B(2)	3784349	6	6	6	3	2	4	0	0	0	0	0.751	0.985	1.000
383	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CIITA(1), HLA-A(1), HLA-C(2), HLA-DOA(1), HLA-DQA1(1), HLA-F(1), HSP90AB1(1), HSPA5(1), IFI30(1), IFNA7(1), KIR3DL1(1), KLRC3(2), KLRC4(1), PSME2(2), TAP2(1)	10790807	18	14	18	4	3	9	3	2	1	0	0.282	0.985	1.000
384	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(3), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), SEPHS2(2), WBSCR22(1)	5718896	14	13	14	5	3	7	2	0	2	0	0.613	0.986	1.000
385	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(1), ATR(2), BRCA1(1), CDC25A(1), CDC25B(2), CDC25C(1), EP300(2), MYT1(1), PRKDC(3), RPS6KA1(2), TP53(2), YWHAQ(1)	9737799	19	19	19	5	3	8	3	1	4	0	0.528	0.987	1.000
386	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), HEXA(1), LCT(2), MAN2B1(2), MAN2B2(1), MAN2C1(2), NEU1(1), NEU4(1)	4799882	11	11	11	5	1	8	0	0	2	0	0.698	0.987	1.000
387	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(1), ALOX12B(3), ALOX15(1), ALOX5(1), CYP2C19(1), CYP2J2(1), CYP2U1(2), GGT1(1), GPX1(1), LTA4H(1), PLA2G6(1), PTGES(1)	9208604	15	15	15	4	7	6	1	0	1	0	0.314	0.987	1.000
388	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNE1(1), CDC25A(1), CDK7(1), RBL1(1), TFDP1(1)	3651285	5	5	5	3	1	3	0	1	0	0	0.854	0.988	1.000
389	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(2), HDAC5(1), MAPK7(3), MEF2A(3), MEF2B(1), MEF2C(1), NFATC2(4), PIK3CA(3), PIK3R1(1)	8054062	19	18	15	6	4	13	1	1	0	0	0.395	0.988	1.000
390	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1)	3664181	6	4	6	4	2	3	0	0	1	0	0.868	0.989	1.000
391	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(1), AR(3), CCL15(1), EGFR(1), GNAQ(1), ITPR1(4), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(1), MAPK10(1), PIK3CA(3), PIK3CD(4), PIK3R1(1), RAF1(1)	12348508	31	26	29	9	7	12	5	3	4	0	0.336	0.990	1.000
392	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRB(1), COX10(1), EPRS(2), FTMT(1), HMOX2(1), UGT1A10(1), UGT1A4(1), UGT2A3(1), UGT2B10(1), UGT2B11(1), UGT2B7(1)	9222560	12	12	12	4	1	6	1	3	1	0	0.603	0.990	1.000
393	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), ITPR1(4), ITPR2(3), ITPR3(5), PDE6A(2), PDE6B(2), PDE6D(1), SLC6A13(1)	8302548	20	18	20	7	5	7	3	1	4	0	0.506	0.990	1.000
394	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(1), CAMK2D(1), HRAS(1), JAK2(2), MAP2K2(1), PTK2B(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1)	9678962	14	13	14	4	4	5	1	2	2	0	0.474	0.991	1.000
395	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT3(1), HRAS(1), KRAS(19), MAP2K2(1), MAPK11(1), NFATC2(4), NFATC4(1), NOS3(1), NRAS(7), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PLA2G6(1), PPP3R2(1), PTK2(1), PXN(2), RAC1(4), RAF1(1), SPHK2(1)	16884591	58	45	40	14	7	28	11	12	0	0	0.123	0.991	1.000
396	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(1), BRCA1(1), RAD51(1), RELA(1), TP53(2), TP73(2)	6695148	8	8	8	3	1	6	1	0	0	0	0.729	0.992	1.000
397	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAL(1), ITGAM(1), ITGB2(3), SELL(1), SELP(1)	3693009	8	8	8	5	2	4	0	1	1	0	0.868	0.992	1.000
398	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(1), AXIN1(2), CD14(1), FZD1(1), GJA1(1), PDPK1(1), PIK3CA(3), PIK3R1(1), RELA(1), TIRAP(2), WNT1(1)	7142644	15	15	14	5	5	6	2	1	1	0	0.525	0.993	1.000
399	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), ITGAL(1), ITGB2(3)	3840218	7	7	7	5	1	3	0	2	1	0	0.941	0.993	1.000
400	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), GALNS(1), GNS(1), HEXA(1), HYAL2(1), IDUA(2), LCT(2), MAN2B1(2), MAN2B2(1), MAN2C1(2), NAGLU(1), NEU1(1), NEU4(1)	8173171	18	18	18	6	3	10	3	0	2	0	0.463	0.993	1.000
401	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(3), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MAT1A(1)	4012043	8	8	8	8	3	4	0	0	1	0	0.987	0.993	1.000
402	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), ATIC(1), DHFR(1), MTHFD1L(1), MTHFR(1)	4360773	5	5	5	3	2	2	0	0	1	0	0.884	0.994	1.000
403	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), GLA(1), LCT(2), NEU1(1), NEU4(1), SMPD1(1)	5599836	7	7	7	3	0	5	1	1	0	0	0.784	0.995	1.000
404	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACMSD(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), AOC3(1), AOX1(1), CYP19A1(1), CYP1A1(2), CYP2A6(1), CYP2C19(1), CYP2D6(1), CYP2J2(1), CYP4B1(1), DDC(2), ECHS1(1), EHHADH(1), MAOA(2), TPH1(2)	12473619	23	20	23	6	2	12	3	1	5	0	0.280	0.995	1.000
405	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAQ(1), GNAS(1), HRAS(1), MYL2(1), PIK3C2G(2), PTK2(1), RAF1(1), ROCK2(1)	5863843	10	9	10	4	2	4	1	2	1	0	0.824	0.995	1.000
406	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP3(1), DFFB(1), FADD(1), LMNB1(2), LMNB2(1), MADD(1), MAP3K7(1), PAK1(1), PRKDC(3), SPTAN1(4), TNFRSF1A(1), TRAF2(1)	9150941	18	17	18	5	4	10	2	1	1	0	0.423	0.996	1.000
407	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN4(2), BCAR1(1), CDH5(2), CLDN10(1), CLDN14(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN23(1), CLDN5(2), CTNNA2(1), CTNND1(2), CYBB(1), ITGA4(1), ITGAL(1), ITGAM(1), ITGB2(3), MAPK11(1), MLLT4(2), MYL2(1), MYLPF(1), NCF4(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PTK2(1), PTK2B(1), PXN(2), RAC1(4), RAP1B(1), RAPGEF3(3), RASSF5(1), RHOA(1), ROCK1(1), ROCK2(1), SIPA1(3), THY1(1), VAV1(2), VAV3(1), VCAM1(1), VCL(1)	28936479	65	55	62	12	15	28	6	7	9	0	0.0206	0.996	1.000
408	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT3(1), IRS1(1), IRS2(3), JAK1(1), PIK3CA(3), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RAF1(1), SOCS1(1), SOS1(3)	8402553	20	15	18	7	6	6	3	2	3	0	0.612	0.996	1.000
409	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP2(2), G6PD(1), GPI(1), PGD(2), PGLS(1), TKT(1), TKTL1(1)	5553056	10	10	10	6	1	6	1	0	2	0	0.853	0.996	1.000
410	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	HRAS(1), MAP2K2(1), NFATC2(4), NFATC4(1), PAK1(1), PIK3C2G(2), RAC1(4), RAF1(1), RELA(1)	9001962	16	16	15	5	4	7	3	2	0	0	0.498	0.997	1.000
411	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	PAFAH1B1(1), PAFAH1B3(2), PLA2G6(1)	5408089	4	4	4	2	2	1	0	0	1	0	0.833	0.997	1.000
412	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1R(1), C5(2), C7(1)	7049066	4	4	4	0	0	4	0	0	0	0	0.247	0.997	1.000
413	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT3(1), BCL2L1(1), CBL(1), CBLC(1), CNTF(1), CNTFR(1), CREBBP(6), CSF2RA(1), CSF3R(2), EP300(2), IFNA7(1), IFNAR1(1), IFNAR2(1), IL11(1), IL12RB1(1), IL19(1), IL21R(1), IL2RB(1), IL3RA(1), IL7R(1), IL9R(2), IRF9(1), JAK1(1), JAK2(2), LIF(1), MYC(1), OSMR(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PRLR(2), SOCS1(1), SOCS2(1), SOCS4(1), SOCS7(1), SOS1(3), SPRED2(1), SPRY4(1), STAM(1), STAT1(2), STAT3(1), TYK2(3)	33355855	65	55	63	12	7	34	7	9	8	0	0.0335	0.997	1.000
414	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2A(1), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(3), MEF2B(1), MEF2C(1)	4872732	11	11	9	7	4	5	1	0	1	0	0.885	0.997	1.000
415	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP2(2), G6PD(1), GPI(1), PGD(2), PGLS(1), TKT(1)	4589106	9	9	9	6	1	6	1	0	1	0	0.889	0.998	1.000
416	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C5(2), C7(1), ITGA4(1), ITGAL(1), ITGB2(3), SELP(1), SELPLG(3), VCAM1(1)	5602260	13	12	13	5	2	6	1	3	1	0	0.671	0.998	1.000
417	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(3), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MAT1A(1)	4787241	8	8	8	8	3	4	0	0	1	0	0.988	0.998	1.000
418	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP4(2), ARHGAP6(1), ARHGEF1(2), ARHGEF5(1), ARPC1B(1), ARPC2(1), DIAPH1(3), MYL2(1), OPHN1(1), PIP5K1A(1), ROCK1(1), TLN1(1), VCL(1)	11046322	18	18	18	5	4	9	3	2	0	0	0.408	0.998	1.000
419	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(1), ADH4(1), ALDH3A1(2), ALDH3B2(1), AOC3(1), AOX1(1), DBH(1), DDC(2), MAOA(2), TH(1), TYR(1)	7224964	14	13	14	5	3	8	2	0	1	0	0.492	0.998	1.000
420	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	FADD(1), MAP3K14(1), MAP3K7(1), RELA(1), TNFAIP3(1), TNFRSF1A(1)	5773199	6	6	6	3	1	3	1	1	0	0	0.844	0.998	1.000
421	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4B(2), EIF4G1(2), EIF4G2(1), EIF4G3(2), PDK2(1), PDPK1(1), PIK3CA(3), PIK3R1(1), TSC2(1)	6424632	14	14	13	5	3	8	0	3	0	0	0.683	0.998	1.000
422	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT3(1), GNAQ(1), ITPR1(4), ITPR2(3), ITPR3(5), NFKB2(2), NFKBIB(1), NFKBIL1(2), PIK3CB(2)	10675264	23	21	23	7	4	9	3	3	4	0	0.414	0.999	1.000
423	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), ALDH5A1(1), CAD(1), CPS1(3), EPRS(2), GAD1(1), GAD2(1), GLUD2(1), GPT2(1), GSR(2), NADSYN1(1)	8955292	15	15	15	5	2	9	0	3	1	0	0.560	0.999	1.000
424	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ANPEP(1), CTSG(1), ENPEP(1)	4800263	5	5	5	3	1	4	0	0	0	0	0.836	0.999	1.000
425	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1R(1), C5(2), C7(1)	7783408	4	4	4	0	0	4	0	0	0	0	0.248	0.999	1.000
426	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(1), E2F4(1), ETV3(1), FOS(2), HDAC5(1), HRAS(1), NCOR2(5), RBL1(1), RBL2(1), SIN3B(1)	6247684	16	12	16	6	2	10	4	0	0	0	0.595	0.999	1.000
427	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTN4(2), AKT3(1), AMOTL1(1), ASH1L(1), CASK(1), CLDN10(1), CLDN14(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN23(1), CLDN5(2), CSNK2A1(1), CSNK2B(1), CTNNA2(1), EPB41(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), HCLS1(2), HRAS(1), INADL(1), KRAS(19), LLGL1(1), LLGL2(2), MAGI2(3), MLLT4(2), MPDZ(1), MYH10(3), MYH11(2), MYH13(1), MYH14(4), MYH15(1), MYH3(1), MYH4(1), MYH6(2), MYH7(2), MYH7B(4), MYH8(1), MYH9(2), MYL2(1), MYLPF(1), NRAS(7), PARD3(1), PPP2R1A(2), PPP2R2A(2), PPP2R2B(2), PRKCH(2), PRKCI(1), RHOA(1), SPTAN1(4), SYMPK(3), TJAP1(2), TJP1(1), TJP2(1), TJP3(2), ZAK(1)	44457017	113	80	98	19	16	58	13	13	13	0	0.000998	0.999	1.000
428	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	CARS(1), EPRS(2), MARS(1), YARS(1)	7158554	5	5	5	4	1	2	0	0	2	0	0.945	0.999	1.000
429	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), DFFB(1), FADD(1), FAF1(2), LMNB1(2), LMNB2(1), MAP3K7(1), PAK1(1), PRKDC(3), PTPN13(1), SPTAN1(4)	9821990	18	18	18	5	3	10	2	1	2	0	0.478	0.999	1.000
430	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1R(1), C5(2), C7(1)	7940642	4	4	4	0	0	4	0	0	0	0	0.248	0.999	1.000
431	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	APOA1(1), APOA2(2), CPT1B(1), CREBBP(6), EHHADH(1), EP300(2), HSD17B4(1), ME1(1), MYC(1), NCOR1(1), NCOR2(5), PIK3CA(3), PIK3R1(1), PRKAR2B(2), RELA(1), SP1(1), SRA1(1)	14643313	31	27	30	9	2	17	5	3	4	0	0.422	0.999	1.000
432	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ITGA9(1), ITPR1(4), ITPR2(3), ITPR3(5), NR1I3(1), PAK1(1), PDE3A(1), PDE3B(1), PIK3C2G(2), PIK3CA(3), PIK3CD(4), PIK3R1(1)	11384972	27	25	25	9	4	13	5	2	3	0	0.513	0.999	1.000
433	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CD14(1), HCLS1(2), NCL(1), RHOA(1), ROCK1(1), ROCK2(1), TUBA1A(3), TUBA1C(1), TUBB(1), TUBB1(1), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1)	11952224	18	17	18	6	3	6	1	2	6	0	0.698	0.999	1.000
434	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CD14(1), HCLS1(2), NCL(1), RHOA(1), ROCK1(1), ROCK2(1), TUBA1A(3), TUBA1C(1), TUBB(1), TUBB1(1), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1)	11952224	18	17	18	6	3	6	1	2	6	0	0.698	0.999	1.000
435	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC2(4), NFATC4(1), SP1(1)	4767373	7	7	7	4	1	3	2	1	0	0	0.866	0.999	1.000
436	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1B(1), ADH4(1), ALDH3A1(2), ALDH3B2(1), AOC3(1), AOX1(1), DBH(1), DDC(2), ESCO1(1), MAOA(2), NAT6(1), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), TH(1), TYR(1), TYRP1(1), WBSCR22(1)	13499813	22	21	22	6	4	13	2	0	3	0	0.303	0.999	1.000
437	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	MAP3K14(1), MAP3K7(1), RELA(1), TGFB1(1)	6769956	4	4	4	2	1	3	0	0	0	0	0.819	0.999	1.000
438	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	EGFR(1), FOS(2), HRAS(1), MAP3K14(1), PRKCH(2), RAF1(1), RELA(1), SP1(1), TNFRSF1A(1), TRAF2(1)	10886329	12	11	12	4	1	8	2	0	1	0	0.512	0.999	1.000
439	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), CKMT1B(1), CPS1(3), EPRS(2), GLUD2(1), NOS3(1), PARS2(1), PRODH(2), PYCRL(1), RARS2(1)	8476408	14	13	13	7	2	6	0	3	3	0	0.905	0.999	1.000
440	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(1), ARF1(1), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1C2(1), GNAS(1), TRIM23(2)	8518851	10	8	10	3	4	3	0	1	2	0	0.558	1.000	1.000
441	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	MCM10(3), MCM2(1), MCM3(1), MCM4(1), MCM6(2), MCM7(2), NACA(3), POLD1(2), POLD3(1), POLE(2), RFC3(4), UBB(1)	11641618	23	21	21	7	3	13	3	2	2	0	0.527	1.000	1.000
442	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CREB5(1), EEF2K(1), MAP3K10(1), MAP3K7(1), MAPK11(1), MKNK2(2), MYEF2(1)	7857621	8	7	8	8	4	0	2	0	2	0	0.980	1.000	1.000
443	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACMSD(1), ALDH1B1(1), ALDH3A1(2), AOC3(1), AOX1(1), CYP1A1(2), DDC(2), ECHS1(1), EHHADH(1), HSD17B4(1), MAOA(2), NFX1(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(1), TPH1(2), WBSCR22(1)	13759202	25	22	25	8	2	15	2	2	4	0	0.418	1.000	1.000
444	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), AKR1B1(1), ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), HAGH(1), LDHD(1), ME1(1), PC(2), PCK1(1), PDHA1(1), PDHA2(1)	8340929	14	14	14	5	6	6	1	1	0	0	0.547	1.000	1.000
445	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(2), CDR1(1), DGKI(2), RPL13A(1), RPL18(2), RPL19(2), RPL22(1), RPL26(1), RPL3(1), RPL31(1), RPL5(2), RPLP0(2), RPLP1(1), RPS14(1), RPS19(1), RPS5(1), RPS6KA1(2), RPS6KA6(1), RPS7(1), UBB(1)	11815937	27	24	26	8	10	9	1	1	6	0	0.599	1.000	1.000
446	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), INPP4A(1), INPP5E(1), INPPL1(1), IPMK(1), MINPP1(1), MIOX(1), OCRL(1), PI4KB(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIP4K2A(1), PIP5K1A(1), PLCB2(1), PLCB3(2), PLCE1(2), PLCZ1(2), SYNJ1(1), SYNJ2(2)	17260578	30	28	28	8	3	16	6	3	2	0	0.268	1.000	1.000
447	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F12(2), F5(1), F8(2), LPA(2), VWF(1)	8184507	8	8	8	4	2	3	1	0	2	0	0.791	1.000	1.000
448	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(1), MYC(1), TNKS(1), TP53(2), XRCC5(1)	6368935	6	6	6	7	1	2	1	1	1	0	0.995	1.000	1.000
449	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	CCKBR(2), CCR3(1), CELSR1(10), CELSR2(2), CHRM3(1), GNRHR(1), GRM1(2), LPHN2(2), LPHN3(1), LTB4R2(2), P2RY13(1)	15223909	25	22	24	7	6	10	5	3	1	0	0.261	1.000	1.000
450	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT3(1), ANKRD6(1), APC(1), AXIN1(2), CSNK1A1(1), LRP1(2), MVP(1), NKD1(1), NKD2(2), PTPRA(1), SFRP1(1)	9379307	14	14	13	5	1	8	2	0	3	0	0.686	1.000	1.000
451	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), FOS(2), MAP3K14(1), MAP3K7(1), RELA(1), TIRAP(2), TLR2(1), TLR7(2), TLR9(1)	8520576	12	12	12	5	4	6	0	0	2	0	0.704	1.000	1.000
452	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ARRB2(2), CAMK2A(1), CAMK2D(1), CLCA1(1)	7075738	6	6	5	6	1	2	2	0	1	0	0.970	1.000	1.000
453	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACADM(1), ALDH1B1(1), ALDH3A1(2), AOX1(1), AUH(1), BCKDHB(1), DBT(1), ECHS1(1), EHHADH(1), HIBCH(1), HMGCL(1), HSD17B4(1), PCCA(3)	10005590	16	16	16	6	1	10	2	1	2	0	0.644	1.000	1.000
454	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT3(1), EGFR(1), ITPR1(4), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(1), PIK3CB(2), PLCB2(1), PLCB3(2), RAF1(1), SOS1(3), STAT3(1)	13455257	26	23	26	9	5	9	3	4	5	0	0.575	1.000	1.000
455	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO1(1), CLYBL(1), IDH3A(1), PC(2), PCK1(1), SDHA(2), SDHB(1), SUCLG2(2)	6721001	12	12	12	5	2	9	0	0	1	0	0.650	1.000	1.000
456	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(1), AVPR1B(1), AVPR2(1), BDKRB2(1), BRS3(1), CCKBR(2), CCR10(1), CCR3(1), GALR1(3), GNRHR(1), LHCGR(3), MC1R(1), MC3R(1), NPY1R(1), OPRD1(1), SSTR3(1)	11679663	21	19	20	8	7	7	1	4	2	0	0.542	1.000	1.000
457	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT2(1), AOC3(1), ATP6V0C(1), CBS(3), CHKA(1), CPT1B(1), MAOA(2), PLCB2(1), SARDH(1)	9777747	12	12	12	6	3	5	1	0	3	0	0.756	1.000	1.000
458	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1), ATP7B(1), COX10(1), COX5A(1), COX7A2(1), NDUFB5(1), NDUFB6(1), NDUFS1(1), NDUFV1(1), SDHA(2), SDHB(1)	8730017	18	15	18	9	3	13	0	0	2	0	0.800	1.000	1.000
459	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	CARS(1), DARS2(1), EPRS(2), FARSB(2), HARS2(1), IARS2(1), MARS(1), PARS2(1), RARS2(1), VARS2(4), YARS(1), YARS2(1)	12245277	17	17	17	7	2	6	5	0	4	0	0.771	1.000	1.000
460	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPPL2(2), ATP13A2(2), DDX47(1), DDX51(2), DDX54(2), DDX55(1), DHFR(1), ENTPD7(1), EP400(2), ERCC2(1), FPGS(1), IFIH1(1), RUVBL2(1), SETX(3), SMARCA2(1), SMARCA5(2)	14450183	25	23	25	9	4	9	2	4	6	0	0.726	1.000	1.000
461	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BIRC2(1), CASP3(1), DFFB(1), FADD(1), MAP3K14(1), RELA(1), SPTAN1(4), TRAF2(1)	7742104	11	11	11	8	1	7	2	0	1	0	0.962	1.000	1.000
462	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT3(1), DLG4(1), LPA(2), NFKB2(2), NFKBIB(1), NFKBIL1(2), PIK3CB(2), PTK2(1), ROCK1(1), ROCK2(1)	11740791	14	13	14	5	2	7	0	2	3	0	0.658	1.000	1.000
463	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(1), CCNE1(1), CDC25A(1), CDK7(1), CDKN1C(3), CREB3L3(1), E2F4(1), GBA2(1), MCM2(1), MCM3(1), MCM4(1), MCM6(2), MCM7(2), MYC(1), MYT1(1), NACA(3), POLE(2), RBL1(1), TFDP1(1), TNXB(4), TP53(2)	17882299	32	28	32	9	8	15	6	2	1	0	0.324	1.000	1.000
464	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(1), ATR(2), BRCA1(1), BRCA2(1), FANCA(1), FANCG(1), RAD51(1), TP53(2), TREX1(2)	9869126	12	12	12	5	1	6	4	0	1	0	0.791	1.000	1.000
465	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPPL1(1), MIOX(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(2), PLCB2(1), PLCB3(2)	10404003	16	15	15	6	0	10	2	3	1	0	0.668	1.000	1.000
466	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADL(1), ACADM(1), ACADVL(1), ACSL5(1), ACSL6(1), ADH1B(1), ADH4(1), ALDH1B1(1), ALDH3A1(2), CPT1A(1), CPT1B(1), CPT2(1), ECHS1(1), EHHADH(1), HSD17B4(1)	11103324	16	16	16	8	3	9	1	1	2	0	0.834	1.000	1.000
467	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM17(1), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1), CASP3(1), CCL5(1), CSK(2), EGFR(1), GIT1(1), MAP3K14(1), MAPK10(1), MAPK11(1), NFKB2(2), NOD1(1), PAK1(1), RAC1(4), RELA(1), TCIRG1(3), TJP1(1)	16336322	29	24	28	9	7	15	3	2	2	0	0.364	1.000	1.000
468	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT3(1), CCL5(1), CD14(1), FADD(1), FOS(2), IFNA7(1), IFNAR1(1), IFNAR2(1), IKBKE(1), IRF5(1), MAP2K2(1), MAP3K7(1), MAPK10(1), MAPK11(1), NFKB2(2), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), RAC1(4), RELA(1), STAT1(2), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR7(2), TLR9(1), TRAF3(1)	20652195	45	42	42	13	12	20	5	5	3	0	0.287	1.000	1.000
469	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN4(2), DES(1), DMD(4), MYBPC1(1), MYBPC2(1), MYBPC3(1), MYH3(1), MYH6(2), MYH7(2), MYH8(1), MYL2(1), MYOM1(1), NEB(6), TMOD1(1), TNNI2(1), TNNT3(1), TPM4(1), TTN(11)	31999442	41	31	41	6	8	21	3	5	3	1	0.0465	1.000	1.000
470	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA12(1), ABCA13(1), ABCA2(3), ABCA3(1), ABCA4(1), ABCA5(1), ABCA6(2), ABCA7(2), ABCB11(1), ABCB4(1), ABCB5(1), ABCB8(2), ABCB9(1), ABCC1(1), ABCC10(2), ABCC12(1), ABCC2(1), ABCC4(1), ABCC5(1), ABCC6(2), ABCC8(5), ABCC9(2), ABCD1(3), ABCD3(1), ABCG8(1), CFTR(2), TAP2(1)	27507588	43	34	43	10	11	19	4	8	1	0	0.104	1.000	1.000
471	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT2(1), AOC3(1), CBS(3), CHKA(1), MAOA(2), PHGDH(1), RDH13(2), SARDH(1)	9904066	12	12	12	6	3	6	1	1	1	0	0.775	1.000	1.000
472	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	EGFR(1), ERBB2(3), ETV6(1), ETV7(2), FMN2(3), KRAS(19), NOTCH1(5), NOTCH3(4), NOTCH4(1), PIWIL3(1), PIWIL4(2), RAF1(1), SOS1(3)	12207707	46	39	34	15	5	17	7	12	5	0	0.624	1.000	1.000
473	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), EGFR(1), GJA1(1), GNAQ(1), GNAS(1), GRM1(2), GRM5(2), GUCY2C(1), GUCY2D(3), HRAS(1), ITPR1(4), ITPR2(3), ITPR3(5), KRAS(19), MAP2K2(1), MAP3K2(1), MAPK7(3), NPR1(1), NPR2(4), NRAS(7), PDGFD(1), PDGFRA(1), PLCB2(1), PLCB3(2), RAF1(1), SOS1(3), TJP1(1), TUBA1A(3), TUBA1C(1), TUBB(1), TUBB1(1), TUBB8(1)	30549931	85	67	69	21	12	38	12	14	9	0	0.0788	1.000	1.000
474	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT3(1), BCL2L1(1), CREB5(1), EBP(1), GAB1(1), INPPL1(1), IRS1(1), IRS2(3), MYC(1), PAK1(1), PAK3(1), PARD3(1), PIK3CA(3), PIK3CD(4), PPP1R13B(1), PREX1(2), PTK2(1), PTPN1(1), RPS6KA1(2), SOS1(3), TSC2(1), YWHAG(1), YWHAQ(1), YWHAZ(1)	17591752	35	29	33	10	6	14	6	4	5	0	0.332	1.000	1.000
475	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1B1(1), ALDH3A1(2), ALDH4A1(1), AOC3(1), CKMT1B(1), CPS1(3), MAOA(2), NOS3(1), SMS(1)	10319515	14	14	14	7	3	7	1	2	1	0	0.813	1.000	1.000
476	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG13(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT7(2), CHPF(1), CHST1(1), CHST12(1), CHST2(3), CHST3(1), CHST4(2), EXT2(1), FUT8(1), GALNT1(1), GALNT10(1), GALNT7(1), GALNTL5(1), GANAB(1), HS6ST1(1), HS6ST2(1), MAN1B1(1), MAN1C1(1), MGAT3(2), MGAT4B(2), MGAT5B(1), NDST1(2), OGT(1), ST3GAL2(1), ST3GAL4(1), ST6GALNAC1(2), STT3B(1), UST(1), WBSCR17(1), XYLT1(1)	25523416	43	37	43	10	9	17	7	3	7	0	0.138	1.000	1.000
477	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(1), AKR1B1(1), ALDH1B1(1), ALDH3A1(2), HAGH(1), LDHAL6A(1), LDHD(1), ME1(1), PC(2), PCK1(1), PDHA1(1), PDHA2(1)	10557758	15	15	15	7	5	7	1	1	1	0	0.753	1.000	1.000
478	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN4(2), ACVR1B(1), CREBBP(6), CSNK2A1(1), CSNK2B(1), CTNNA2(1), CTNND1(2), EGFR(1), EP300(2), ERBB2(3), FARP2(1), FER(1), FGFR1(1), IQGAP1(3), LMO7(1), MAP3K7(1), MLLT4(2), PARD3(1), PTPN1(1), PTPRB(1), PTPRF(3), PVRL3(1), RAC1(4), RHOA(1), SMAD4(1), SNAI1(1), SORBS1(1), TJP1(1), VCL(1), WASF2(2), WASL(2)	27523290	51	43	50	12	7	22	3	8	11	0	0.206	1.000	1.000
479	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(1), FOS(2), HRAS(1), MAP2K2(1), MAP3K10(1), MAP3K11(2), MAP3K14(1), MAP3K2(1), MAP3K3(2), MAP3K6(1), MAP3K7(1), MAP3K9(1), MAP4K2(1), MAPK10(1), MAPK11(1), MAPK6(1), MAPK7(3), MEF2A(3), MEF2B(1), MEF2C(1), MKNK2(2), MYC(1), PAK1(1), RAC1(4), RAF1(1), RELA(1), RPS6KA1(2), RPS6KA4(2), RPS6KA5(1), SP1(1), STAT1(2), TGFB1(1), TRAF2(1)	22805140	47	40	43	13	15	21	4	5	2	0	0.178	1.000	1.000
480	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	FLNA(2), FSCN1(1), FSCN2(1), MYLK2(1), PAK1(1), PAK3(1), PFN2(1), RHO(1), ROCK1(1), ROCK2(1), WASL(2)	11162736	13	13	13	5	3	4	2	2	2	0	0.769	1.000	1.000
481	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2L1(1), CASP3(1), DFFB(1), FADD(1), IKBKE(1), NGFR(1), NR3C1(1), NTRK1(1), PTPN13(1), TFG(1), TNFRSF1A(1), TRAF2(1), TRAF3(1)	10056975	13	11	13	5	1	7	3	0	2	0	0.726	1.000	1.000
482	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CANT1(1), CDA(1), CTPS2(2), DHODH(2), POLB(1), POLD1(2), POLE(2), POLG(2), POLQ(1), POLRMT(1), TK2(1), TXNRD1(1), UMPS(1), UPP1(1)	13250619	20	20	20	9	5	8	4	1	2	0	0.756	1.000	1.000
483	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	CACNA1A(2), CRHR1(1), GNA12(1), GNAQ(1), GNAS(1), GRIA1(2), GRID2(1), GRM1(2), GRM5(2), GUCY2C(1), GUCY2D(3), HRAS(1), ITPR1(4), ITPR2(3), ITPR3(5), KRAS(19), MAP2K2(1), NOS3(1), NPR1(1), NPR2(4), NRAS(7), PLA2G6(1), PLCB2(1), PLCB3(2), PPP2R1A(2), PPP2R2A(2), PPP2R2B(2), RAF1(1), RYR1(5)	25789504	79	62	64	22	13	36	9	12	9	0	0.157	1.000	1.000
484	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AMY1A(1), ATP13A2(2), DDX47(1), DDX51(2), DDX54(2), DDX55(1), ENPP3(1), ENTPD7(1), EP400(2), ERCC2(1), GPI(1), GYS1(3), GYS2(2), HK2(3), HK3(3), IFIH1(1), MGAM(1), PYGB(2), RUVBL2(1), SETX(3), SI(2), SMARCA2(1), SMARCA5(2), UGT1A10(1), UGT1A4(1), UGT2A3(1), UGT2B10(1), UGT2B11(1), UGT2B7(1)	30309592	45	40	45	11	13	17	3	7	5	0	0.242	1.000	1.000
485	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), AKAP11(1), AKAP12(1), AKAP3(1), AKAP9(2), ARHGEF1(2), GNA12(1), GNAQ(1), GNG4(1), HRAS(1), ITPR1(4), KCNJ3(1), KRAS(19), NRAS(7), PALM2(1), PDE1B(1), PDE7A(1), PLCB3(2), PRKAR2B(2), PRKCH(2), PRKCI(1), RHOA(1), SLC9A1(1), USP5(1)	26641081	62	49	47	18	4	30	12	9	7	0	0.300	1.000	1.000
486	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(1), ACSL5(1), ACSL6(1), APOA1(1), APOA2(2), APOA5(2), AQP7(3), CPT1A(1), CPT1B(1), CPT2(1), CYP7A1(2), DBI(2), EHHADH(1), GK2(1), ILK(1), ME1(1), MMP1(1), PCK1(1), PDPK1(1), PLTP(1), PPARD(1), PPARG(1), RXRB(1), SORBS1(1), UCP1(1)	14953083	32	27	32	11	7	14	3	4	4	0	0.581	1.000	1.000
487	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1B(1), ACVR2A(1), ACVR2B(1), AMH(2), AMHR2(1), BMP7(1), BMPR1A(1), BMPR2(1), CCL15(1), CCL18(1), CCL5(1), CCR3(1), CCR9(1), CNTF(1), CNTFR(1), CSF1(1), CSF2RA(1), CSF3R(2), CXCL6(1), EDA(1), EDA2R(1), EGFR(1), FLT1(1), FLT3(1), FLT3LG(2), FLT4(1), GDF5(2), IFNA7(1), IFNAR1(1), IFNAR2(1), IL11(1), IL12RB1(1), IL17RA(1), IL18RAP(2), IL19(1), IL21R(1), IL2RB(1), IL3RA(1), IL7R(1), IL9R(2), INHBB(1), KIT(27), LIF(1), NGFR(1), OSMR(1), PDGFRA(1), PF4V1(1), PLEKHO2(2), PRLR(2), TGFB1(1), TNFRSF13C(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF6B(1), VEGFB(1)	40887041	89	65	75	25	12	36	14	21	6	0	0.230	1.000	1.000
488	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ARHGEF12(2), DPYSL5(1), EPHA2(1), EPHA3(1), EPHA5(1), EPHA6(2), EPHB1(2), EPHB4(3), EPHB6(1), HRAS(1), KRAS(19), LRRC4C(1), NFATC2(4), NFATC4(1), NGEF(2), NRAS(7), NTN4(1), PAK1(1), PAK3(1), PLXNA2(2), PLXNB1(1), PLXNB2(4), PLXNB3(1), PLXNC1(5), PPP3R2(1), PTK2(1), RAC1(4), RGS3(1), RHOA(1), RHOD(1), ROBO1(1), ROBO2(1), ROBO3(3), ROCK1(1), ROCK2(1), SEMA3E(1), SEMA3F(1), SEMA4B(1), SEMA4G(1), SEMA5A(1), SEMA5B(2), SEMA6A(1), SEMA6B(4), SEMA6C(1), SEMA6D(1), SLIT1(5), SLIT2(2), SLIT3(1), SRGAP3(1), UNC5A(1), UNC5B(2), UNC5D(1)	45919958	108	75	92	28	19	48	18	16	7	0	0.0728	1.000	1.000
489	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADORA2A(2), AVPR1B(1), AVPR2(1), BDKRB2(1), BRS3(1), CCKBR(2), CHRM1(2), CHRM3(1), CHRM5(1), CRHR1(1), CTSG(1), CYSLTR2(1), DRD3(1), F2RL3(2), GABBR2(1), GABRA1(1), GABRA4(1), GABRB1(1), GABRB2(1), GABRB3(1), GABRD(1), GABRE(2), GABRG1(1), GABRG2(1), GABRP(1), GALR1(3), GLRA1(1), GLRB(1), GNRHR(1), GPR35(1), GRIA1(2), GRIA4(3), GRID2(1), GRIK1(1), GRIK3(2), GRIK4(1), GRIK5(1), GRIN2A(1), GRIN2B(2), GRIN2D(2), GRIN3A(1), GRIN3B(1), GRM1(2), GRM4(2), GRM5(2), GRM8(2), HRH1(1), HRH3(1), HTR1D(2), HTR5A(2), KISS1R(1), LHCGR(3), LTB4R(2), LTB4R2(2), MC1R(1), MC3R(1), NPFFR1(1), NPY1R(1), NR3C1(1), OPRD1(1), P2RX2(1), P2RX3(1), P2RX5(1), P2RY1(1), P2RY13(1), P2RY4(1), P2RY8(1), PARD3(1), PRLR(2), PRSS3(7), PTGER3(1), RXFP1(1), RXFP2(1), SSTR3(1), TAAR2(2), THRA(2), TRPV1(1), VIPR1(1)	50650994	110	74	105	28	28	50	14	12	6	0	0.0199	1.000	1.000
490	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), CACNA1C(4), CACNA1D(1), CACNA1S(1), CAMK2A(1), CAMK2D(1), EGFR(1), GNAQ(1), GNAS(1), GNRHR(1), HRAS(1), ITPR1(4), ITPR2(3), ITPR3(5), KRAS(19), MAP2K2(1), MAP3K2(1), MAP3K3(2), MAPK10(1), MAPK11(1), MAPK7(3), NRAS(7), PLA2G6(1), PLCB2(1), PLCB3(2), PTK2B(1), RAF1(1), SOS1(3)	30140291	76	64	60	22	10	34	13	12	7	0	0.213	1.000	1.000
491	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC10(1), ANAPC11(1), ANAPC2(1), ATM(1), ATR(2), CCNE1(1), CDC14A(1), CDC23(1), CDC25A(1), CDC25B(2), CDC25C(1), CDC27(6), CDK7(1), CDKN1C(3), CREBBP(6), EP300(2), FZR1(2), MAD1L1(1), MAD2L2(1), MCM2(1), MCM3(1), MCM4(1), MCM6(2), MCM7(2), PKMYT1(1), PRKDC(3), RBL1(1), RBL2(1), SKP2(1), SMAD4(1), SMC1B(1), TFDP1(1), TGFB1(1), TP53(2), YWHAG(1), YWHAQ(1), YWHAZ(1)	31399637	58	50	56	16	6	30	11	2	9	0	0.278	1.000	1.000
492	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), COL11A1(2), COL11A2(2), COL3A1(1), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(1), COL6A3(3), FN1(2), FNDC1(3), FNDC4(1), HMMR(2), HSPG2(3), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(1), ITGA4(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGB3(1), ITGB4(1), ITGB7(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(2), LAMA5(10), LAMB1(1), LAMB2(3), LAMB3(2), LAMB4(2), LAMC3(8), RELN(2), SDC1(1), SDC2(1), SDC3(1), SV2B(1), THBS1(1), THBS3(1), TNR(1), TNXB(4), VWF(1)	52721935	99	69	98	23	31	52	9	3	4	0	0.0204	1.000	1.000
493	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	DGKD(2), DGKG(1), DGKI(2), DGKQ(3), DGKZ(4), FN3K(1), INPP4A(1), INPP5D(1), INPP5E(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(5), OCRL(1), PI4KB(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PIP4K2A(1), PIP5K1A(1), PLCB2(1), PLCB3(2), PLCE1(2), PLCZ1(2), SYNJ1(1), SYNJ2(2)	29222756	58	49	56	18	10	26	9	6	7	0	0.336	1.000	1.000
494	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(1), BMPR1A(1), BMPR2(1), CDKL1(1), CLK1(1), CSNK2A1(1), CSNK2B(1), DGKD(2), DGKG(1), DGKQ(3), DGKZ(4), INPP4A(1), INPPL1(1), MAP3K10(1), MOS(1), NEK1(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(2), PIM2(1), PLCB2(1), PLCB3(2), PRKAR2B(2), PRKCH(2), RAF1(1), RPS6KA1(2), RPS6KA4(2)	26421753	45	39	44	14	11	21	5	3	5	0	0.373	1.000	1.000
495	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(2), BDKRB2(1), C1QC(1), C1R(1), C5(2), C7(1), CFH(1), CR1(3), F12(2), F13A1(2), F5(1), F8(2), SERPINA1(1), VWF(1)	24012164	21	18	21	8	5	11	2	2	1	0	0.627	1.000	1.000
496	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CD226(1), CD276(2), CD6(1), CDH15(2), CDH5(2), CLDN10(1), CLDN14(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN23(1), CLDN5(2), CNTNAP2(1), GLG1(1), HLA-A(1), HLA-C(2), HLA-DOA(1), HLA-DQA1(1), HLA-F(1), ICAM3(2), ITGA4(1), ITGA8(1), ITGA9(1), ITGAL(1), ITGAM(1), ITGB2(3), ITGB7(1), ITGB8(1), MAG(4), NCAM1(4), NCAM2(1), NFASC(1), NLGN1(1), NLGN2(4), NLGN3(1), NRXN2(3), NRXN3(1), PTPRF(3), PVRL3(1), SDC1(1), SDC2(1), SDC3(1), SELL(1), SELP(1), SELPLG(3), SIGLEC1(4), VCAM1(1), VCAN(1)	33942346	74	58	74	24	16	31	8	10	9	0	0.326	1.000	1.000
497	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(1), CCNE1(1), CDC14A(1), CDC25A(1), CDC25B(2), CDC25C(1), E2F4(1), EP300(2), HDAC4(1), HDAC5(1), HDAC8(1), MAD1L1(1), MAD2L2(1), MCM2(1), MCM3(1), MCM4(1), MCM6(2), MCM7(2), PRKDC(3), PTPRA(1), RBL1(1), SKP2(1), SMAD4(1), TBC1D8(1), TFDP1(1), TGFB1(1), TP53(2)	25531267	34	28	34	11	6	19	4	2	3	0	0.461	1.000	1.000
498	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(1), APC2(2), AXIN1(2), CAMK2A(1), CAMK2D(1), CHD8(1), CREBBP(6), CSNK1A1(1), CSNK2A1(1), CSNK2B(1), CTBP2(1), DAAM2(1), EP300(2), FZD1(1), FZD4(1), FZD8(3), LRP5(4), LRP6(1), MAP3K7(1), MAPK10(1), MYC(1), NFATC2(4), NFATC4(1), NKD1(1), NKD2(2), PLCB2(1), PLCB3(2), PORCN(2), PPARD(1), PPP2R1A(2), PPP2R2A(2), PPP2R2B(2), PPP3R2(1), PRICKLE2(2), RAC1(4), RHOA(1), ROCK1(1), ROCK2(1), SFRP1(1), SMAD4(1), TP53(2), VANGL2(1), WNT1(1), WNT11(2), WNT3(1), WNT4(1), WNT5B(2), WNT8B(2), WNT9B(1)	37266885	79	71	77	25	18	34	8	6	13	0	0.286	1.000	1.000
499	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN4(2), APC(1), APC2(2), ARHGEF1(2), ARHGEF12(2), ARHGEF4(1), ARHGEF6(1), ARPC1B(1), ARPC2(1), BCAR1(1), BDKRB2(1), CD14(1), CHRM1(2), CHRM3(1), CHRM5(1), CRK(1), CSK(2), CYFIP1(1), DIAPH1(3), DIAPH3(1), DOCK1(1), EGFR(1), FGD1(3), FGD3(1), FGF11(2), FGF20(1), FGF23(1), FGFR1(1), FGFR3(2), FGFR4(1), FN1(2), GIT1(1), GNA12(1), HRAS(1), IQGAP1(3), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(1), ITGA4(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAX(3), ITGB2(3), ITGB3(1), ITGB4(1), ITGB7(1), ITGB8(1), KRAS(19), MAP2K2(1), MOS(1), MYH10(3), MYH14(4), MYH9(2), MYL2(1), MYLK2(1), MYLPF(1), NRAS(7), PAK1(1), PAK3(1), PDGFRA(1), PFN2(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PIP4K2A(1), PIP5K1A(1), PPP1CA(1), PPP1R12A(1), PTK2(1), PXN(2), RAC1(4), RAF1(1), RHOA(1), ROCK1(1), ROCK2(1), SCIN(1), SLC9A1(1), SOS1(3), SSH1(1), SSH3(2), TIAM1(4), TIAM2(1), VAV1(2), VAV3(1), VCL(1), WASF2(2), WASL(2)	64895016	165	98	146	35	34	76	22	20	13	0	0.00222	1.000	1.000
500	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(1), AKT3(1), ARRB2(2), ATF2(1), CACNA1A(2), CACNA1C(4), CACNA1D(1), CACNA1E(2), CACNA1G(2), CACNA1H(3), CACNA1I(1), CACNA1S(1), CACNA2D2(1), CACNB2(1), CACNG8(1), CASP3(1), CD14(1), CDC25B(2), CRK(1), DUSP16(1), DUSP4(4), DUSP5(1), DUSP8(1), DUSP9(1), EGFR(1), FGF11(2), FGF20(1), FGF23(1), FGFR1(1), FGFR3(2), FGFR4(1), FLNA(2), FLNB(2), FOS(2), GNA12(1), HRAS(1), KRAS(19), MAP2K2(1), MAP3K10(1), MAP3K14(1), MAP3K2(1), MAP3K3(2), MAP3K6(1), MAP3K7(1), MAP4K2(1), MAPK10(1), MAPK11(1), MAPK7(3), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MEF2C(1), MKNK2(2), MOS(1), MYC(1), NF1(3), NFATC2(4), NFATC4(1), NFKB2(2), NRAS(7), NTRK1(1), PAK1(1), PDGFRA(1), PLA2G6(1), PPP3R2(1), RAC1(4), RAF1(1), RAP1B(1), RAPGEF2(1), RASA2(1), RASGRF1(2), RASGRP1(1), RASGRP4(1), RPS6KA1(2), RPS6KA4(2), RPS6KA5(1), RPS6KA6(1), SOS1(3), STK3(1), STK4(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFB1(1), TNFRSF1A(1), TP53(2), TRAF2(1), ZAK(1)	68692130	155	94	137	42	35	67	25	16	12	0	0.0285	1.000	1.000
501	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN4(2), AKT3(1), BCAR1(1), BIRC2(1), CAV1(1), COL11A1(2), COL11A2(2), COL3A1(1), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(1), COL6A3(3), CRK(1), DIAPH1(3), DOCK1(1), EGFR(1), ERBB2(3), FARP2(1), FLNA(2), FLNB(2), FLT1(1), FN1(2), HRAS(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(1), ITGA4(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGB3(1), ITGB4(1), ITGB7(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(2), LAMA5(10), LAMB1(1), LAMB2(3), LAMB3(2), LAMB4(2), LAMC3(8), MAPK10(1), MYL2(1), MYLK2(1), MYLPF(1), PAK1(1), PAK3(1), PDGFD(1), PDGFRA(1), PDPK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP1CA(1), PPP1R12A(1), PTK2(1), PXN(2), RAC1(4), RAF1(1), RAP1B(1), RAPGEF1(3), RELN(2), RHOA(1), ROCK1(1), ROCK2(1), SOS1(3), THBS1(1), THBS3(1), TLN1(1), TLN2(1), TNR(1), TNXB(4), VAV1(2), VAV3(1), VCL(1), VEGFB(1), VWF(1)	86613906	152	90	148	37	36	75	18	13	10	0	0.0164	1.000	1.000
502	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY2(1), ADCY3(1), ADCY7(2), ADCY8(1), ADORA2A(2), ATP2A1(1), ATP2B2(3), ATP2B4(2), AVPR1B(1), BDKRB2(1), BST1(1), CACNA1A(2), CACNA1C(4), CACNA1D(1), CACNA1E(2), CACNA1G(2), CACNA1H(3), CACNA1I(1), CACNA1S(1), CAMK2A(1), CAMK2D(1), CAMK4(3), CCKBR(2), CHRM1(2), CHRM3(1), CHRM5(1), CYSLTR2(1), EGFR(1), ERBB2(3), ERBB3(2), GNAQ(1), GNAS(1), GRIN2A(1), GRIN2D(2), GRM1(2), GRM5(2), HRH1(1), HTR5A(2), ITPR1(4), ITPR2(3), ITPR3(5), LHCGR(3), LTB4R2(2), MYLK2(1), NOS3(1), P2RX2(1), P2RX3(1), P2RX5(1), PDE1B(1), PDGFRA(1), PHKA1(1), PHKB(5), PHKG1(1), PHKG2(1), PLCB2(1), PLCB3(2), PLCE1(2), PLCZ1(2), PPID(2), PPP3R2(1), PTGER3(1), PTK2B(1), RYR1(5), RYR2(3), RYR3(4), SLC25A4(1), SLC25A5(2), SLC8A1(1), SLC8A3(1), SPHK2(1), VDAC2(1)	64342790	125	85	124	48	25	62	13	13	12	0	0.426	1.000	1.000
503	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(1), ACACB(1), AKT3(1), CBL(1), CBLC(1), CRK(1), FASN(2), FBP2(2), GYS1(3), GYS2(2), HRAS(1), INPP5D(1), IRS1(1), IRS2(3), KRAS(19), LIPE(3), MAP2K2(1), MAPK10(1), MKNK2(2), NRAS(7), PCK1(1), PDE3A(1), PDE3B(1), PDPK1(1), PHKA1(1), PHKB(5), PHKG1(1), PHKG2(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP1CA(1), PPP1R3A(2), PPP1R3D(1), PRKAA2(1), PRKAR2B(2), PRKCI(1), PTPN1(1), PTPRF(3), PYGB(2), RAF1(1), RAPGEF1(3), RHEB(2), SOCS1(1), SOCS2(1), SOCS4(1), SORBS1(1), SOS1(3), SREBF1(4), TSC2(1)	37693800	109	77	92	30	17	46	18	15	12	1	0.124	1.000	1.000
504	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	COL11A1(2), COL11A2(2), COL17A1(3), COL3A1(1), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(1), COL6A3(3), DES(1), DSG1(1), FN1(2), GJA1(1), GJA3(1), GJA9(2), ITGB4(1), KRT15(1), KRT19(1), KRT23(1), KRT3(2), KRT32(3), KRT33A(1), KRT33B(1), KRT38(1), KRT6A(2), KRT73(1), KRT74(1), KRT78(1), KRT79(2), KRT82(2), KRT84(2), KRT85(1), KRT9(1), LAMA1(2), LAMA2(3), LAMA3(2), LAMA5(10), LAMB1(1), LAMB2(3), LAMB3(2), LAMB4(2), LAMC3(8), LMNB1(2), LMNB2(1), RELN(2), THBS1(1), THBS3(1), TNR(1), TNXB(4), VWF(1)	58141289	104	74	103	31	30	55	12	3	4	0	0.161	1.000	1.000
505	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), ARRB2(2), ATP2B2(3), CACNA1A(2), CACNA1C(4), CACNA1D(1), CACNA1E(2), CACNA1S(1), CAMK2A(1), CAMK2D(1), CAMK4(3), CHRM1(2), CHRM3(1), CHRM5(1), GJA1(1), GNAQ(1), GNG4(1), GRK4(1), GRK5(1), GRK6(1), ITPR1(4), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(1), NME7(1), PLCB3(2), PRKAR2B(2), PRKCH(2), RGS1(1), RGS14(1), RGS3(1), RGS7(1), RGS9(4), RYR1(5), RYR2(3), RYR3(4), SLC8A1(1), SLC8A3(1), USP5(1), YWHAQ(1)	44288558	82	61	81	33	12	42	15	4	9	0	0.620	1.000	1.000
506	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(1), ACTA2(1), ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), ARRB2(2), ATF2(1), ATF5(1), CAMK2A(1), CAMK2D(1), CRHR1(1), DGKZ(4), FOS(2), GBA2(1), GJA1(1), GNAQ(1), GNG4(1), GRK4(1), GRK5(1), GRK6(1), IGFBP4(1), ITPR1(4), ITPR2(3), ITPR3(5), MYL2(1), MYLK2(1), NOS3(1), PLCB3(2), PRKAR2B(2), PRKCH(2), RGS1(1), RGS14(1), RGS3(1), RGS7(1), RGS9(4), RYR1(5), RYR2(3), RYR3(4), SLC8A1(1), SP1(1), TNXB(4), USP5(1), YWHAQ(1)	40597537	79	60	78	33	11	44	11	4	9	0	0.696	1.000	1.000
507	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), BCAR1(1), CAPN1(1), CAPN3(2), CAPN5(1), CAPN7(2), CAPNS1(2), CAV1(1), CRK(1), CSK(2), DOCK1(1), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(1), ITGA4(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAX(3), ITGB2(3), ITGB3(1), ITGB4(1), ITGB7(1), ITGB8(1), MAP2K2(1), MAPK10(1), MAPK6(1), MAPK7(3), MYLK2(1), PAK1(1), PAK3(1), PDPK1(1), PTK2(1), PXN(2), RAC1(4), RAP1B(1), RAPGEF1(3), RHO(1), ROCK1(1), ROCK2(1), SDCCAG8(1), SORBS1(1), SOS1(3), TLN1(1), TNS1(1), VAV3(1), VCL(1)	31724683	74	59	71	25	17	34	8	7	8	0	0.458	1.000	1.000
508	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(1), ASH2L(1), CTCFL(1), DOT1L(2), EHMT1(2), EHMT2(1), EZH2(4), FBXO11(2), HCFC1(2), HSF4(6), KDM6A(2), MEN1(1), MLL(2), MLL2(2), MLL3(5), MLL4(6), MLL5(2), NSD1(4), OGT(1), PPP1CA(1), PRDM2(1), PRDM7(1), PRDM9(1), PRMT7(1), PRMT8(1), RBBP5(1), SATB1(1), SETD1B(1), SETD7(1), SETMAR(1), STK38(1), SUV39H1(1), SUV420H1(1), WHSC1(1)	29172390	62	48	58	21	8	23	13	4	14	0	0.729	1.000	1.000
509	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), ADSL(2), ADSS(3), AK2(1), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(2), ENTPD6(1), ENTPD8(1), FHIT(1), GMPR(1), GUCY2C(1), GUCY2D(3), GUK1(2), NME7(1), NPR1(1), NPR2(4), NT5C1B(2), PAPSS2(1), PDE10A(1), PDE2A(2), PDE3B(1), PDE5A(1), PDE6D(1), PDE7A(1), PFAS(1), POLA1(3), POLD1(2), POLD3(1), POLE(2), POLE4(1), POLR3A(1), POLR3B(1), XDH(2)	37767133	58	45	58	23	10	31	7	3	7	0	0.700	1.000	1.000
510	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	AKT3(1), ARHGEF6(1), BCAR1(1), CAV1(1), CRK(1), CSE1L(1), DOCK1(1), GRB7(2), ILK(1), ITGA10(1), ITGA11(1), ITGA3(1), ITGA4(1), ITGA7(2), ITGA8(1), ITGA9(1), MAP3K11(2), MAPK10(1), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MYLK2(1), PAK1(1), PAK3(1), PIK3CA(3), PIK3CB(2), PTK2(1), RAF1(1), RHO(1), ROCK1(1), ROCK2(1), SOS1(3), TLN1(1), TLN2(1)	28480438	47	38	46	16	7	24	5	6	5	0	0.497	1.000	1.000
511	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(2), AVPR1B(1), AVPR2(1), BDKRB2(1), BRS3(1), CCKBR(2), CCR10(1), CCR3(1), CCR9(1), CHRM1(2), CHRM3(1), CHRM5(1), DRD3(1), F2RL3(2), GALR1(3), GPR35(1), GPR37(1), GPR6(1), GPR87(1), HRH1(1), HRH3(1), HTR1D(2), HTR5A(2), LHCGR(3), LTB4R(2), MC1R(1), MC3R(1), NPY1R(1), OPN3(1), OPRD1(1), P2RY1(1), P2RY13(1), RHO(1), SSTR3(1)	27515497	45	37	43	17	13	18	7	5	2	0	0.463	1.000	1.000
512	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY2(1), ADCY3(1), ADCY5(2), ADCY7(2), ADCY8(1), ADSL(2), ADSS(3), AK2(1), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(2), FHIT(1), GUCY2C(1), GUCY2D(3), GUK1(2), NPR1(1), NPR2(4), PAPSS2(1), PDE5A(1), PDE6B(2), PFAS(1), POLB(1), POLD1(2), POLE(2), POLG(2), POLQ(1), POLRMT(1)	29586291	44	35	44	20	9	24	5	0	6	0	0.812	1.000	1.000
513	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CANT1(1), CDA(1), CTPS2(2), DHODH(2), ENTPD6(1), ENTPD8(1), NME7(1), NT5C1B(2), POLA1(3), POLD1(2), POLD3(1), POLE(2), POLE4(1), POLR3A(1), POLR3B(1), TK2(1), TXNRD1(1), TXNRD2(2), UMPS(1), UPP1(1), UPRT(1)	18714749	30	29	30	11	5	13	7	3	2	0	0.644	1.000	1.000
514	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(1), AKT3(1), ATM(1), BCL2L1(1), BIRC2(1), CAPN1(1), CASP3(1), DFFB(1), FADD(1), IL3RA(1), MAP3K14(1), NFKB2(2), NTRK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PPP3R2(1), PRKAR2B(2), RELA(1), TNFRSF1A(1), TP53(2), TRAF2(1)	19480043	33	29	31	14	4	16	8	3	2	0	0.823	1.000	1.000
515	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(1), CREBBP(6), CTBP2(1), DLL1(1), DLL4(1), EP300(2), JAG2(2), MAML3(1), NCOR2(5), NCSTN(1), NOTCH1(5), NOTCH3(4), NOTCH4(1), SNW1(1)	16748166	33	29	33	16	5	11	7	2	8	0	0.845	1.000	1.000
516	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(1), ACSL5(1), ACSL6(1), AKT3(1), CAMKK1(2), CPT1A(1), CPT1B(1), CPT2(1), IRS1(1), IRS2(3), JAK1(1), JAK2(2), MAPK10(1), NFKB2(2), NFKBIB(1), PCK1(1), PRKAA2(1), RELA(1), RXRB(1), SLC2A1(2), STAT3(1), TNFRSF1A(1), TRAF2(1), TYK2(3)	19453904	32	29	32	17	11	12	2	1	6	0	0.900	1.000	1.000
517	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CLK3(2), CPSF1(4), CPSF3(1), DDX20(1), DHX38(1), DHX9(2), DICER1(1), FUS(1), METTL3(1), NXF1(1), PRPF8(2), PSKH1(1), PTBP1(2), PTBP2(1), RBM17(1), RNPS1(1), SF3A2(1), SF3B5(1), SNRPB(1), SUPT5H(1), U2AF2(2), XRN2(2)	24302026	33	28	33	17	13	10	6	1	3	0	0.934	1.000	1.000
518	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(1), CASP3(1), CDK2AP1(1), CSNK1A1(1), EGFR(1), FADD(1), FAF1(2), MAPK10(1), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), NFKB2(2), NFKBIB(1), NFKBIL1(2), PFN2(1), PTPN13(1), ROCK1(1), SMPD1(1), TNFRSF6B(1), TP53(2), TRAF2(1)	17262384	31	27	31	11	4	18	4	2	3	0	0.567	1.000	1.000
519	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT3(1), EIF4B(2), HIF1A(3), PDPK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(4), PIK3R1(1), PIK3R5(1), PRKAA2(1), RHEB(2), RICTOR(1), RPS6KA1(2), RPS6KA6(1), TSC2(1), ULK1(2), VEGFB(1)	12510281	29	25	27	12	9	11	5	3	1	0	0.725	1.000	1.000
520	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(1), DLG4(1), GNAQ(1), ITPR1(4), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(1), RAC1(4), RHO(1), RYR1(5)	10649359	27	25	26	13	7	9	4	4	3	0	0.809	1.000	1.000
521	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT3(1), BRD4(2), CBL(1), INPPL1(1), IRS1(1), IRS2(3), PARD3(1), PIK3CA(3), PIK3CD(4), PIK3R1(1), PTPN1(1), RAF1(1), RPS6KA1(2), SORBS1(1), SOS1(3), YWHAG(1), YWHAQ(1), YWHAZ(1)	13459483	29	24	27	11	7	10	5	3	4	0	0.649	1.000	1.000
522	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(3), NR0B1(1), NR1I3(1), NR3C1(1), NR4A2(2), PGR(4), PPARD(1), PPARG(1), RARA(1), RARB(1), RARG(2), RORA(1), RXRB(1), THRA(2), VDR(1)	9825625	25	23	25	11	5	12	3	3	2	0	0.758	1.000	1.000
523	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1D(1), EEF1G(1), EEF2(1), EEF2K(1), EIF1AX(1), EIF2B2(1), EIF2B3(1), EIF4G1(2), EIF4G3(2), EIF5A(1), EIF5B(3), PABPC1(1), PABPC3(4)	10183224	23	23	22	10	3	9	3	4	4	0	0.916	1.000	1.000
524	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	ATF2(1), DUSP4(4), DUSP8(1), GAB1(1), MAP3K10(1), MAP3K11(2), MAP3K2(1), MAP3K3(2), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK7(3), MYEF2(1), TP53(2), ZAK(1)	11501185	23	22	22	11	10	9	3	0	1	0	0.784	1.000	1.000
525	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(1), CREBBP(6), EP300(2), GRIP1(2), GTF2E1(1), HDAC4(1), HDAC5(1), MEF2C(1), NCOR2(5), NR0B1(1), PELP1(2), SRA1(1)	11022784	24	21	24	13	3	14	3	2	2	0	0.932	1.000	1.000
526	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	CHKA(1), DGKD(2), DGKG(1), DGKI(2), DGKQ(3), DGKZ(4), ESCO1(1), ETNK1(1), GNPAT(1), GPD1L(1), LYPLA1(1), NAT6(1), PCYT1B(2), PHOSPHO1(1), PLA2G6(1), PTDSS2(1)	15368190	24	21	24	13	9	10	1	0	4	0	0.893	1.000	1.000
527	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	BCL2L1(1), BIRC2(1), CASP3(1), DFFB(1), FADD(1), IRF4(2), IRF5(1), IRF6(1), MAPK10(1), MYC(1), NFKBIB(1), PLEKHG5(1), RELA(1), TNFRSF1A(1), TNFRSF21(1), TP53(2), TP73(2), TRAF2(1), TRAF3(1)	13478386	22	20	22	10	4	11	4	1	2	0	0.785	1.000	1.000
528	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	CHKA(1), CPT1B(1), DGKD(2), DGKG(1), DGKQ(3), DGKZ(4), ETNK1(1), GNPAT(1), LYPLA1(1), PAFAH1B1(1), PCYT1B(2), PLA2G6(1), PLCB2(1)	11795428	20	20	20	10	7	7	1	0	5	0	0.833	1.000	1.000
529	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP4A(4), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1C2(1), COX10(1), COX5A(1), COX7A2(1), NDUFB5(1), NDUFB6(1), NDUFS1(1), NDUFS3(1), NDUFS7(1), NDUFV1(1), SDHA(2), SDHB(1), TCIRG1(3)	12951770	26	20	26	15	5	15	1	1	4	0	0.916	1.000	1.000
530	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	ALDH1B1(1), ALDH3A1(2), DOT1L(2), ECHS1(1), EHHADH(1), EHMT1(2), EHMT2(1), HSD17B4(1), NSD1(4), PLOD1(1), PLOD2(1), RDH13(2), SETD7(1), SPCS1(1), SUV39H1(1)	13142909	22	20	22	12	3	11	2	2	4	0	0.912	1.000	1.000
531	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP7(1), BMP8B(1), CSNK1A1(1), CSNK1G2(1), GLI3(1), LRP2(4), PTCH1(1), WNT1(1), WNT11(2), WNT3(1), WNT4(1), WNT5B(2), WNT8B(2), WNT9B(1), ZIC2(1)	13791815	21	20	21	10	9	7	3	0	2	0	0.765	1.000	1.000
532	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), BCAR1(1), CAPN1(1), CAPNS1(2), CAPNS2(1), CAV1(1), CSK(2), HRAS(1), MAP2K2(1), PTK2(1), PXN(2), RAF1(1), ROCK1(1), SOS1(3), TLN1(1), VCL(1)	10929354	21	19	20	12	4	8	1	4	4	0	0.968	1.000	1.000
533	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BIRC2(1), CASP3(1), DFFB(1), FADD(1), LMNB1(2), LMNB2(1), MAP3K14(1), NUMA1(1), PRKDC(3), PTK2(1), RELA(1), SPTAN1(4), TNFRSF1A(1), TRAF2(1)	16169237	20	18	20	11	2	13	3	1	1	0	0.932	1.000	1.000
534	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPN1(1), CAPNS1(2), CAPNS2(1), ITGB3(1), PTK2(1), PXN(2), RAC1(4), SPTAN1(4), TLN1(1)	6597953	18	17	16	11	3	7	1	3	4	0	0.971	1.000	1.000
535	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	ATM(1), ATR(2), BAI1(3), CASP3(1), CCNE1(1), PPM1D(1), RFWD2(1), THBS1(1), TP53(2), TP73(2), TSC2(1)	15053914	16	16	16	15	2	9	4	0	1	0	0.998	1.000	1.000
536	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(1), CAV1(1), CHRM1(2), FLT1(1), FLT4(1), NOS3(1), PDE2A(2), PDE3A(1), PDE3B(1), PRKAR2B(2), RYR2(3)	9727171	17	16	17	10	4	10	1	2	0	0	0.890	1.000	1.000
537	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), CASP3(1), CERK(1), CREB5(1), FOS(2), GNAQ(1), MAPK10(1), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4)	6591454	16	15	16	9	1	10	4	1	0	0	0.869	1.000	1.000
538	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), CEBPB(1), CLDN5(2), CLOCK(1), CRY2(2), EIF4G2(1), ETV6(1), HERPUD1(1), NCOA4(2), PER2(2)	8357051	14	14	14	6	4	9	1	0	0	0	0.715	1.000	1.000
539	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), CAPNS1(2), CAPNS2(1), EGFR(1), HRAS(1), MYL2(1), PRKAR2B(2), PTK2(1), PXN(2), TLN1(1)	7643699	14	14	13	13	1	9	0	1	3	0	0.998	1.000	1.000
540	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ARHGEF1(2), F2RL3(2), GNA12(1), GNAQ(1), MAP3K7(1), PIK3CA(3), PIK3R1(1), PTK2B(1), ROCK1(1)	5875872	13	13	12	7	3	6	1	3	0	0	0.865	1.000	1.000
541	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	BCL2L1(1), BIRC2(1), CASP3(1), FADD(1), MAP3K14(1), MAPK10(1), MYC(1), RELA(1), TNFRSF1A(1), TP53(2), TRAF2(1)	8698436	12	12	12	7	1	6	4	1	0	0	0.924	1.000	1.000
542	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ITGB3(1), PDGFRA(1), PIK3CA(3), PIK3R1(1), PTK2(1), RAC1(4), SMPD1(1)	6169172	12	12	10	6	3	5	1	3	0	0	0.843	1.000	1.000
543	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	FOS(2), GNAQ(1), GNAS(1), HRAS(1), NFATC2(4), NFATC4(1), PRKAR2B(2), RAF1(1)	8069108	13	12	13	7	2	8	1	2	0	0	0.865	1.000	1.000
544	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	CERK(1), GLA(1), LCT(2), NEU1(1), NEU4(1), SMPD1(1), SMPD3(2), SMPD4(2), SPHK2(1)	8278490	12	12	12	10	1	9	0	1	1	0	0.984	1.000	1.000
545	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	ATM(1), BCL2L1(1), CASP3(1), PTK2(1), PXN(2), STAT1(2), TLN1(1), TP53(2)	6191015	11	11	11	6	1	7	3	0	0	0	0.893	1.000	1.000
546	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(1), ATR(2), CCNE1(1), CDC25A(1), DHFR(1), SKP2(1), TFDP1(1), TGFB1(1), TP53(2)	6859837	11	11	11	5	2	6	2	1	0	0	0.780	1.000	1.000
547	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT1(1), FUT4(1), PIGN(1), PIGO(1), PIGQ(2), PIGT(1), PIGU(1), PIGX(1), ST3GAL2(1), ST3GAL4(1)	11295365	11	11	11	12	3	7	0	1	0	0	0.996	1.000	1.000
548	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CDK7(1), GTF2E1(1), GTF2H1(3), ILK(1), POLR3B(1), POLR3E(1), TAF5(2), TAF7(2)	8049712	12	11	12	10	0	7	1	3	1	0	0.991	1.000	1.000
549	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PGAP1(2), PIGN(1), PIGO(1), PIGQ(2), PIGT(1), PIGU(1), PIGW(1), PIGX(1)	5663324	10	10	10	5	3	6	0	1	0	0	0.771	1.000	1.000
550	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPNS1(2), CAPNS2(1), EP300(2), NFATC2(4)	5581185	11	10	10	11	1	5	1	1	3	0	0.997	1.000	1.000
551	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	CHRM1(2), CHRM3(1), CHRM5(1), DRD3(1), HRH1(1), HTR1D(2), HTR5A(2)	5966870	10	10	10	5	3	5	2	0	0	0	0.721	1.000	1.000
552	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP3(1), MAGI2(3), RERE(2)	5411037	8	8	8	6	0	4	2	2	0	0	0.969	1.000	1.000
553	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(1), NCOR2(5), RARA(1), THRA(2)	4045103	9	7	9	5	3	2	4	0	0	0	0.852	1.000	1.000
554	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(1), GRIN2B(2), GRIN2D(2), PRKAR2B(2)	5908324	8	7	8	6	3	4	0	1	0	0	0.932	1.000	1.000
555	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(1), CAPNS1(2), CAPNS2(1), CDK5R1(1), CSNK1A1(1)	2246300	7	7	6	12	0	2	1	1	3	0	1.000	1.000	1.000
556	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(1), ALOX15(1), ALOX5(1), GGT1(1), LTA4H(1), MPO(1), PLA2G6(1)	6524167	7	7	7	4	5	1	1	0	0	0	0.788	1.000	1.000
557	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	EGFR(1), FOS(2), HRAS(1), MYC(1), RELA(1)	4632033	6	6	6	4	0	5	0	1	0	0	0.871	1.000	1.000
558	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), CASP3(1), DFFB(1), LMNB1(2), LMNB2(1)	4433238	6	6	6	5	1	3	2	0	0	0	0.966	1.000	1.000
559	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	ENPP3(1), ILVBL(3), PANK4(1), VNN1(1)	4015799	6	6	6	4	1	3	2	0	0	0	0.878	1.000	1.000
560	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	INPPL1(1), PDK2(1), PDPK1(1), PIK3CA(3), PIK3R1(1)	4631045	7	6	6	4	2	4	0	1	0	0	0.864	1.000	1.000
561	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(2), GNA12(1), GNAQ(1), MYL2(1), ROCK1(1)	4691413	6	5	6	5	2	1	1	2	0	0	0.963	1.000	1.000
562	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2E1(1), NCOR2(5), RARA(1)	5793871	7	5	7	15	1	1	4	1	0	0	1.000	1.000	1.000
563	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	FOS(2), GNAQ(1), PTK2B(1)	3083613	4	4	4	3	1	2	0	1	0	0	0.892	1.000	1.000
564	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), PRKAR2B(2)	2937503	4	4	4	4	0	4	0	0	0	0	0.944	1.000	1.000
565	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	HEXA(1), LCT(2), ST3GAL2(1)	3741859	4	4	4	4	0	3	0	1	0	0	0.962	1.000	1.000
566	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2L1(1), BIRC2(1), CASP3(1), DFFB(1)	3081242	4	4	4	7	0	1	3	0	0	0	0.999	1.000	1.000
567	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CPS1(3), HAL(1)	4259538	4	4	4	3	0	3	0	1	0	0	0.928	1.000	1.000
568	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(1), CCNE1(1), TP53(2)	4112720	4	4	4	5	1	2	1	0	0	0	0.990	1.000	1.000
569	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), PRODH(2)	1346011	3	3	2	3	1	0	0	2	0	0	0.967	1.000	1.000
570	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	GATA1(1), HBA2(1)	1939638	2	2	2	2	1	0	1	0	0	0	0.939	1.000	1.000
571	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL2(1), ST3GAL4(1)	1259430	2	2	2	2	0	1	0	1	0	0	0.929	1.000	1.000
572	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), MTHFD1L(1)	2878614	2	2	2	2	1	1	0	0	0	0	0.931	1.000	1.000
573	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), LDHAL6A(1)	2853585	2	2	2	2	1	1	0	0	0	0	0.940	1.000	1.000
574	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), FUT4(1)	3638788	2	2	2	2	1	1	0	0	0	0	0.935	1.000	1.000
575	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), MTHFD1L(1)	3020998	2	2	2	3	1	1	0	0	0	0	0.972	1.000	1.000
576	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	MPO(1), MTHFR(1)	2618801	2	2	2	2	2	0	0	0	0	0	0.911	1.000	1.000
577	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR3A(1), POLR3B(1)	5257012	2	2	2	4	0	1	0	1	0	0	0.994	1.000	1.000
578	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), CASP3(1)	2532012	2	2	2	3	0	1	1	0	0	0	0.989	1.000	1.000
579	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	ENPP3(1), PANK4(1)	3226927	2	2	2	4	0	1	1	0	0	0	0.992	1.000	1.000
580	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), RELA(1)	1895262	2	2	2	3	0	1	0	1	0	0	0.985	1.000	1.000
581	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNE1(1), E2F4(1)	2059701	2	2	2	2	0	1	1	0	0	0	0.935	1.000	1.000
582	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	NR1I3(1)	1180881	1	1	1	3	0	1	0	0	0	0	0.992	1.000	1.000
583	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1)	1385802	1	1	1	2	0	0	1	0	0	0	0.979	1.000	1.000
584	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1)	1432546	1	1	1	2	0	1	0	0	0	0	0.984	1.000	1.000
585	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	CASP3(1)	2856000	1	1	1	4	0	0	1	0	0	0	0.999	1.000	1.000
586	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F5(1)	3751621	1	1	1	2	1	0	0	0	0	0	0.979	1.000	1.000
587	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(1)	1738616	1	1	1	2	0	1	0	0	0	0	0.975	1.000	1.000
588	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ST3GAL4(1)	1640989	1	1	1	2	0	1	0	0	0	0	0.982	1.000	1.000
589	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1)	1653092	1	1	1	4	0	1	0	0	0	0	0.999	1.000	1.000
590	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLRMT(1)	3069890	1	1	1	5	0	1	0	0	0	0	0.999	1.000	1.000
591	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL2L1(1)	2672994	1	1	1	6	0	0	1	0	0	0	1.000	1.000	1.000
592	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1)	2633085	1	1	1	4	1	0	0	0	0	0	0.998	1.000	1.000
593	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	GNAQ(1)	1373863	1	1	1	2	0	0	0	1	0	0	0.982	1.000	1.000
594	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8		887734	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
595	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4		530141	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
596	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7		1171565	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
597	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5		860243	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
598	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9		1767052	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
599	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		379005	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
600	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4		1065632	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
601	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3		585027	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
602	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		161508	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
603	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6		1146312	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
604	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		112867	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		496652	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		340251	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6		993498	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13		1419808	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6		687207	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
610	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5		1558663	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5		912937	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
612	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28		4997025	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		731253	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10		2062878	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		261218	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		752966	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000