Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	31.0	1468.0	46.0	-0.957	0.017	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by the Hedgehog family	27.0	1411.0	52.0	-0.394	0.24	1000.0	-1000.0	-0.098	-1000.0
IL23-mediated signaling events	25.0	1513.0	60.0	-0.5	0.022	1000.0	-1000.0	-0.154	-1000.0
IL4-mediated signaling events	23.0	2100.0	91.0	-0.657	0.57	1000.0	-1000.0	-0.154	-1000.0
Syndecan-1-mediated signaling events	22.0	764.0	34.0	-0.312	0.011	1000.0	-1000.0	-0.081	-1000.0
Ephrin A  reverse signaling	22.0	160.0	7.0	-0.159	0.0	1000.0	-1000.0	-0.039	-1000.0
Syndecan-4-mediated signaling events	18.0	1207.0	67.0	-0.301	0.042	1000.0	-1000.0	-0.104	-1000.0
amb2 Integrin signaling	17.0	1453.0	82.0	-0.354	0.011	1000.0	-1000.0	-0.095	-1000.0
Wnt signaling	17.0	125.0	7.0	-0.135	0.009	1000.0	-1000.0	-0.067	-1000.0
Osteopontin-mediated events	16.0	642.0	38.0	-0.231	0.011	1000.0	-1000.0	-0.113	-1000.0
Glypican 1 network	16.0	774.0	48.0	-0.332	0.025	1000.0	-1000.0	-0.061	-1000.0
Endothelins	16.0	1576.0	96.0	-0.231	0.011	1000.0	-1000.0	-0.093	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	533.0	34.0	-0.122	0.011	1000.0	-1000.0	-0.082	-1000.0
p75(NTR)-mediated signaling	15.0	1943.0	125.0	-0.439	0.011	1000.0	-1000.0	-0.105	-1000.0
Glucocorticoid receptor regulatory network	15.0	1816.0	114.0	-0.698	0.299	1000.0	-1000.0	-0.085	-1000.0
Reelin signaling pathway	15.0	892.0	56.0	-0.264	0.011	1000.0	-1000.0	-0.103	-1000.0
E-cadherin signaling events	15.0	77.0	5.0	-0.142	0.011	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1181.0	78.0	-0.196	0.103	1000.0	-1000.0	-0.08	-1000.0
IL12-mediated signaling events	14.0	1285.0	87.0	-0.328	0.113	1000.0	-1000.0	-0.132	-1000.0
Integrins in angiogenesis	14.0	1235.0	84.0	-0.339	0.022	1000.0	-1000.0	-0.113	-1000.0
Calcium signaling in the CD4+ TCR pathway	14.0	462.0	31.0	-0.398	0.011	1000.0	-1000.0	-0.128	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	14.0	987.0	68.0	-0.418	0.053	1000.0	-1000.0	-0.146	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1058.0	74.0	-0.16	0.087	1000.0	-1000.0	-0.119	-1000.0
BMP receptor signaling	13.0	1090.0	81.0	-0.294	0.045	1000.0	-1000.0	-0.108	-1000.0
Signaling events regulated by Ret tyrosine kinase	12.0	1060.0	82.0	-0.182	0.011	1000.0	-1000.0	-0.093	-1000.0
IL27-mediated signaling events	12.0	617.0	51.0	-0.252	0.122	1000.0	-1000.0	-0.106	-1000.0
Caspase cascade in apoptosis	11.0	885.0	74.0	-0.23	0.085	1000.0	-1000.0	-0.05	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1075.0	93.0	-0.153	0.027	1000.0	-1000.0	-0.092	-1000.0
IL6-mediated signaling events	11.0	860.0	75.0	-0.246	0.049	1000.0	-1000.0	-0.096	-1000.0
Noncanonical Wnt signaling pathway	10.0	278.0	26.0	-0.163	0.011	1000.0	-1000.0	-0.103	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	417.0	44.0	-0.231	0.011	1000.0	-1000.0	-0.056	-1000.0
LPA receptor mediated events	9.0	995.0	102.0	-0.184	0.011	1000.0	-1000.0	-0.114	-1000.0
IGF1 pathway	9.0	533.0	57.0	-0.122	0.018	1000.0	-1000.0	-0.112	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1160.0	120.0	-0.328	0.26	1000.0	-1000.0	-0.099	-1000.0
HIF-1-alpha transcription factor network	8.0	614.0	76.0	-0.203	0.058	1000.0	-1000.0	-0.141	-1000.0
Arf6 signaling events	8.0	508.0	62.0	-0.24	0.011	1000.0	-1000.0	-0.077	-1000.0
Nectin adhesion pathway	8.0	520.0	63.0	-0.21	0.019	1000.0	-1000.0	-0.084	-1000.0
Nongenotropic Androgen signaling	8.0	455.0	52.0	-0.126	0.021	1000.0	-1000.0	-0.067	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	672.0	76.0	-0.143	0.011	1000.0	-1000.0	-0.097	-1000.0
BCR signaling pathway	8.0	813.0	99.0	-0.153	0.03	1000.0	-1000.0	-0.106	-1000.0
Coregulation of Androgen receptor activity	7.0	602.0	76.0	-0.583	0.023	1000.0	-1000.0	-0.061	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	415.0	54.0	-0.284	0.022	1000.0	-1000.0	-0.112	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	440.0	61.0	-0.261	0.018	1000.0	-1000.0	-0.087	-1000.0
Syndecan-3-mediated signaling events	7.0	262.0	35.0	-0.146	0.011	1000.0	-1000.0	-0.073	-1000.0
EGFR-dependent Endothelin signaling events	7.0	157.0	21.0	-0.096	0.011	1000.0	-1000.0	-0.075	-1000.0
Regulation of Androgen receptor activity	7.0	499.0	70.0	-0.595	0.028	1000.0	-1000.0	-0.075	-1000.0
ErbB4 signaling events	6.0	442.0	69.0	-0.391	0.087	1000.0	-1000.0	-0.094	-1000.0
BARD1 signaling events	6.0	351.0	57.0	-0.077	0.068	1000.0	-1000.0	-0.076	-1000.0
Visual signal transduction: Cones	6.0	245.0	38.0	-0.086	0.011	1000.0	-1000.0	-0.081	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	117.0	17.0	-0.089	0.011	1000.0	-1000.0	-0.077	-1000.0
IFN-gamma pathway	6.0	445.0	68.0	-0.18	0.029	1000.0	-1000.0	-0.11	-1000.0
Ephrin B reverse signaling	6.0	299.0	48.0	-0.1	0.071	1000.0	-1000.0	-0.084	-1000.0
FAS signaling pathway (CD95)	6.0	318.0	47.0	-0.144	0.02	1000.0	-1000.0	-0.059	-1000.0
Canonical Wnt signaling pathway	6.0	332.0	51.0	-0.261	0.041	1000.0	-1000.0	-0.067	-1000.0
Effects of Botulinum toxin	6.0	175.0	26.0	-0.101	0.011	1000.0	-1000.0	-0.076	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	106.0	17.0	-0.038	0.01	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	5.0	71.0	12.0	-0.121	0.016	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	693.0	136.0	-0.29	0.104	1000.0	-1000.0	-0.095	-1000.0
Thromboxane A2 receptor signaling	5.0	578.0	105.0	-0.092	0.035	1000.0	-1000.0	-0.084	-1000.0
Syndecan-2-mediated signaling events	5.0	404.0	69.0	-0.146	0.036	1000.0	-1000.0	-0.074	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	26.0	5.0	-0.051	-0.009	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by PTP1B	5.0	453.0	76.0	-0.163	0.04	1000.0	-1000.0	-0.088	-1000.0
PDGFR-alpha signaling pathway	5.0	220.0	44.0	-0.203	0.025	1000.0	-1000.0	-0.075	-1000.0
Retinoic acid receptors-mediated signaling	5.0	313.0	58.0	-0.086	0.025	1000.0	-1000.0	-0.071	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	229.0	45.0	-0.123	0.02	1000.0	-1000.0	-0.095	-1000.0
EPHB forward signaling	5.0	434.0	85.0	-0.159	0.059	1000.0	-1000.0	-0.116	-1000.0
TCGA08_retinoblastoma	5.0	47.0	8.0	-0.026	0.012	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Rods	5.0	289.0	52.0	-0.106	0.011	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by PRL	5.0	176.0	34.0	-0.243	0.033	1000.0	-1000.0	-0.06	-1000.0
ErbB2/ErbB3 signaling events	4.0	274.0	65.0	-0.077	0.026	1000.0	-1000.0	-0.08	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	409.0	85.0	-0.139	0.011	1000.0	-1000.0	-0.096	-1000.0
EPO signaling pathway	4.0	237.0	55.0	-0.065	0.041	1000.0	-1000.0	-0.114	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	475.0	97.0	-0.122	0.026	1000.0	-1000.0	-0.106	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	173.0	37.0	-0.118	0.012	1000.0	-1000.0	-0.096	-1000.0
IL1-mediated signaling events	4.0	299.0	62.0	-0.153	0.059	1000.0	-1000.0	-0.123	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	255.0	52.0	-0.104	0.019	1000.0	-1000.0	-0.069	-1000.0
IL2 signaling events mediated by PI3K	4.0	288.0	58.0	-0.105	0.029	1000.0	-1000.0	-0.094	-1000.0
Regulation of p38-alpha and p38-beta	4.0	240.0	54.0	-0.163	0.011	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by STAT5	4.0	109.0	22.0	-0.086	0.012	1000.0	-1000.0	-0.054	-1000.0
Regulation of Telomerase	4.0	456.0	102.0	-0.184	0.039	1000.0	-1000.0	-0.116	-1000.0
E-cadherin signaling in keratinocytes	4.0	212.0	43.0	-0.151	0.036	1000.0	-1000.0	-0.084	-1000.0
Cellular roles of Anthrax toxin	3.0	133.0	39.0	-0.056	0.015	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	3.0	218.0	60.0	-0.353	0.035	1000.0	-1000.0	-0.068	-1000.0
Ceramide signaling pathway	3.0	293.0	76.0	-0.117	0.025	1000.0	-1000.0	-0.075	-1000.0
TRAIL signaling pathway	3.0	181.0	48.0	-0.035	0.024	1000.0	-1000.0	-0.074	-1000.0
HIF-2-alpha transcription factor network	3.0	132.0	43.0	-0.086	0.028	1000.0	-1000.0	-0.102	-1000.0
TCGA08_p53	3.0	23.0	7.0	-0.011	0.011	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	3.0	305.0	86.0	-0.117	0.046	1000.0	-1000.0	-0.09	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	328.0	88.0	-0.188	0.081	1000.0	-1000.0	-0.12	-1000.0
FOXM1 transcription factor network	3.0	200.0	51.0	-0.103	0.139	1000.0	-1000.0	-0.165	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	80.0	28.0	-0.077	0.019	1000.0	-1000.0	-0.065	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	-0.012	0.011	1000.0	-1000.0	-0.022	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	137.0	65.0	-0.262	0.05	1000.0	-1000.0	-0.067	-1000.0
Aurora C signaling	2.0	15.0	7.0	-0.026	0.005	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by HDAC Class III	2.0	109.0	40.0	-0.091	0.025	1000.0	-1000.0	-0.049	-1000.0
ceramide signaling pathway	2.0	141.0	49.0	-0.059	0.028	1000.0	-1000.0	-0.047	-1000.0
FoxO family signaling	2.0	170.0	64.0	-0.157	0.093	1000.0	-1000.0	-0.079	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	72.0	36.0	-0.051	0.022	1000.0	-1000.0	-0.092	-1000.0
Atypical NF-kappaB pathway	2.0	62.0	31.0	-0.042	0.022	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	304.0	125.0	-0.101	0.066	1000.0	-1000.0	-0.126	-1000.0
TCGA08_rtk_signaling	2.0	58.0	26.0	-0.054	0.037	1000.0	-1000.0	-0.026	-1000.0
Class I PI3K signaling events	2.0	183.0	73.0	-0.163	0.026	1000.0	-1000.0	-0.092	-1000.0
Insulin Pathway	2.0	215.0	74.0	-0.068	0.034	1000.0	-1000.0	-0.102	-1000.0
S1P3 pathway	2.0	94.0	42.0	-0.077	0.035	1000.0	-1000.0	-0.068	-1000.0
Rapid glucocorticoid signaling	2.0	59.0	20.0	-0.05	0.011	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.0	-1000.0	1000.0	-1000.0	-0.017	-1000.0
S1P4 pathway	2.0	61.0	25.0	-0.035	0.011	1000.0	-1000.0	-0.063	-1000.0
p38 MAPK signaling pathway	2.0	113.0	44.0	-0.076	0.016	1000.0	-1000.0	-0.074	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	28.0	23.0	-0.054	0.041	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class II	1.0	75.0	75.0	-0.108	0.017	1000.0	-1000.0	-0.07	-1000.0
PLK1 signaling events	1.0	93.0	85.0	-0.03	0.028	1000.0	-1000.0	-0.057	-1000.0
mTOR signaling pathway	1.0	89.0	53.0	-0.022	0.024	1000.0	-1000.0	-0.074	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	88.0	68.0	-0.064	0.04	1000.0	-1000.0	-0.076	-1000.0
S1P5 pathway	1.0	21.0	17.0	-0.021	0.018	1000.0	-1000.0	-0.058	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	92.0	83.0	-0.064	0.059	1000.0	-1000.0	-0.093	-1000.0
S1P1 pathway	1.0	50.0	36.0	-0.027	0.026	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by HDAC Class I	1.0	173.0	104.0	-0.108	0.046	1000.0	-1000.0	-0.079	-1000.0
Glypican 2 network	1.0	6.0	4.0	-0.009	0.005	1000.0	-1000.0	-0.038	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	50.0	33.0	-0.066	0.029	1000.0	-1000.0	-0.069	-1000.0
PDGFR-beta signaling pathway	1.0	103.0	97.0	-0.098	0.058	1000.0	-1000.0	-0.101	-1000.0
Aurora B signaling	1.0	108.0	67.0	-0.077	0.027	1000.0	-1000.0	-0.078	-1000.0
Canonical NF-kappaB pathway	0.0	34.0	39.0	-0.059	0.078	1000.0	-1000.0	-0.093	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.014	0.043	1000.0	-1000.0	-0.085	-1000.0
Arf6 downstream pathway	0.0	10.0	43.0	-0.026	0.028	1000.0	-1000.0	-0.05	-1000.0
Insulin-mediated glucose transport	0.0	25.0	32.0	-0.064	0.04	1000.0	-1000.0	-0.071	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.007	0.032	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.001	0.028	1000.0	-1000.0	-0.066	-1000.0
Arf6 trafficking events	0.0	27.0	71.0	-0.037	0.037	1000.0	-1000.0	-0.09	-1000.0
VEGFR1 specific signals	0.0	53.0	56.0	-0.035	0.061	1000.0	-1000.0	-0.102	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.007	0.031	1000.0	-1000.0	-0.059	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.005	0.011	1000.0	-1000.0	-0.077	-1000.0
Total	865	54641	7203	-21.7006571405	-994.565967229	131000	-131000	-10.8376433443	-131000